Experts and Doctors on rna interference in Netherlands

Summary

Locale: Netherlands
Topic: rna interference

Top Publications

  1. van der Oost J, Brouns S. RNAi: prokaryotes get in on the act. Cell. 2009;139:863-5 pubmed publisher
    ..Hale et al. (2009) now report on a new variant CRISPR/Cas complex in the archaeon Pyrococcus furiosus that uses guide RNAs to specifically target and cleave RNA not DNA. ..
  2. Gimeno R, Weijer K, Voordouw A, Uittenbogaart C, Legrand N, Alves N, et al. Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells. Blood. 2004;104:3886-93 pubmed
    ..Inactivating p53 did not affect the development of CD34(+) cells into various mature leukocyte subsets, including T cells, but it conferred resistance to gamma-irradiation and other p53-dependent apoptotic stimuli to the T cells. ..
  3. Lansbergen G, Komarova Y, Modesti M, Wyman C, Hoogenraad C, Goodson H, et al. Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. J Cell Biol. 2004;166:1003-14 pubmed
    ..This interaction interferes with the binding of the CLIP-170 to MTs. We propose that conformational changes in CLIP-170 are important for binding to dynactin, LIS1, and the MT tips. ..
  4. Vacaru A, Tafesse F, Ternes P, Kondylis V, Hermansson M, Brouwers J, et al. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J Cell Biol. 2009;185:1013-27 pubmed publisher
    ..Our results establish SMSr as a key regulator of ceramide homeostasis that seems to operate as a sensor rather than a converter of ceramides in the ER. ..
  5. Marteijn J, Bekker Jensen S, Mailand N, Lans H, Schwertman P, Gourdin A, et al. Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response. J Cell Biol. 2009;186:835-47 pubmed publisher
    ..Although both lesions are processed by independent repair pathways and trigger signaling responses by distinct kinases, they eventually generate the same epigenetic mark, possibly functioning in DNA damage signal amplification. ..
  6. Smeenk G, Wiegant W, Vrolijk H, Solari A, Pastink A, van Attikum H. The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J Cell Biol. 2010;190:741-9 pubmed publisher
    ..Finally, we show that CHD4 promotes DSB repair and checkpoint activation in response to IR. Thus, the NuRD chromatin-remodeling complex is a novel regulator of DNA damage responses that orchestrates proper signaling and repair of DSBs. ..
  7. Kulozik P, Jones A, Mattijssen F, Rose A, Reimann A, Strzoda D, et al. Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab. 2011;13:389-400 pubmed publisher
  8. Westerman B, Braat A, Taub N, Potman M, Vissers J, Blom M, et al. A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation. J Exp Med. 2011;208:2675-89 pubmed publisher
    ..Knockdown of Mp1 in invasive GCT cells resulted in resistance to differentiation, thereby showing a functional role for Mp1 both in normal differentiation of ES cells and in germ cell cancer. ..
  9. Raaijmakers J, Tanenbaum M, Medema R. Systematic dissection of dynein regulators in mitosis. J Cell Biol. 2013;201:201-15 pubmed publisher

More Information

Publications14

  1. Ivanova I, Vermeulen J, Ercan C, Houthuijzen J, Saig F, Vlug E, et al. FER kinase promotes breast cancer metastasis by regulating ?6- and ?1-integrin-dependent cell adhesion and anoikis resistance. Oncogene. 2013;32:5582-92 pubmed publisher
    ..These findings establish FER as a promising target for the prevention and inhibition of metastatic breast cancer. ..
  2. Schotte R, Nagasawa M, Weijer K, Spits H, Blom B. The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J Exp Med. 2004;200:1503-9 pubmed
    ..However, in contrast to Spi-B, PU.1 knock down inhibited B cell and myeloid cell development as well. These results identify Spi-B as a key regulator of human pDC development. ..
  3. Schnettler E, Hemmes H, Huismann R, Goldbach R, Prins M, Kormelink R. Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules. J Virol. 2010;84:11542-54 pubmed publisher
    ..The observed affinity to long dsRNA for only a subset of the tospoviruses studied is discussed in light of evolutional divergence and their ancestral relation to the animal-infecting members of the Bunyaviridae...
  4. Jacobs C, van der Zee M. Immune competence in insect eggs depends on the extraembryonic serosa. Dev Comp Immunol. 2013;41:263-9 pubmed publisher
    ..Drosophila eggs and serosa-less Tribolium eggs, however, show little to no upregulation of any of the tested immune genes. We conclude that the extraembryonic serosa is crucial for the early immune competence of the Tribolium egg...
  5. Riemer P, Rydenfelt M, Marks M, van Eunen K, Thedieck K, Herrmann B, et al. Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. J Cell Biol. 2017;216:1567-1577 pubmed publisher
    ..Our work defines phenotypes, signaling network states, and vulnerabilities of transgenic intestinal organoids as a novel approach to understanding oncogene activities and guiding the development of targeted therapies. ..