Genomes and Genes
Experts and Doctors on rna binding proteins in Germany
Topic: rna binding proteins
Publications171 found, 100 shown here
- Lermontova I, Schubert V, Börnke F, Macas J, Schubert I. Arabidopsis CBF5 interacts with the H/ACA snoRNP assembly factor NAF1. Plant Mol Biol. 2007;65:615-26 pubmed..The homologous yeast protein has been shown to contribute to RNA pseudouridinylation. Thus, AtCBF5 might have an essential function in RNA processing rather than being a kinetochore protein. ..
- Clayton C, Schwede A, Stewart M, Robles A, Benz C, Po J, et al. Control of mRNA degradation in trypanosomes. Biochem Soc Trans. 2008;36:520-1 pubmed publisher..Targeted RNA interference screening was used to identify RNA-binding proteins that regulate mRNA degradation, and it revealed roles for proteins with RNA recognition motifs or pumilio domains. ..
- Slanchev K, Stebler J, Goudarzi M, Cojocaru V, Weidinger G, Raz E. Control of Dead end localization and activity--implications for the function of the protein in antagonizing miRNA function. Mech Dev. 2009;126:270-7 pubmed publisher..Based on molecular modeling, we identify the putative RNA binding domain of Dnd as a canonical RRM and propose that this domain is important for protein subcellular localization and function. ..
- Bessonov S, Anokhina M, Krasauskas A, Golas M, Sander B, Will C, et al. Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA. 2010;16:2384-403 pubmed publisher..The overall architecture of the human and S. cerevisiae B(act) complex is similar, suggesting that many of the higher order interactions among spliceosomal components, as well as their dynamics, are also largely conserved. ..
- Mangel L, Ternes T, Schmitz B, Doerfler W. New 5'-(CGG)n-3' repeats in the human genome. J Biol Chem. 1998;273:30466-71 pubmed..Lung and colon carcinoma cell lines in which some microsatellites were shown to be unstable were also investigated. Expansions of the 5'-(CGG)n-3' repeats were not found. ..
- Simon J, Eichler R, Pisa R, Biel S, Gross R. Modification of heme c binding motifs in the small subunit (NrfH) of the Wolinella succinogenes cytochrome c nitrite reductase complex. FEBS Lett. 2002;522:83-7 pubmed..succinogenes is able to attach heme to an SXXCH motif...
- Kullmann M, Göpfert U, Siewe B, Hengst L. ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. Genes Dev. 2002;16:3087-99 pubmed..Consistent with an inhibitory role of Hu proteins in p27 translation, siRNA mediated knockdown of HuR induced endogenous p27 protein levels as well as IRES-mediated reporter translation and leads to cell cycle arrest in G1. ..
- Rudnik Schoneborn S, Goebel H, Schlote W, Molaian S, Omran H, Ketelsen U, et al. Classical infantile spinal muscular atrophy with SMN deficiency causes sensory neuronopathy. Neurology. 2003;60:983-7 pubmed
- Sun Y, Grimmler M, Schwarzer V, Schoenen F, Fischer U, Wirth B. Molecular and functional analysis of intragenic SMN1 mutations in patients with spinal muscular atrophy. Hum Mutat. 2005;25:64-71 pubmed..However, all mutations, including those in exon 2a, a region shown to be important for the binding of SMN to SIP1, do not disturb the interaction of SMN to SIP1. ..
- Korf M, Jarczak D, Beger C, Manns M, Krüger M. Inhibition of hepatitis C virus translation and subgenomic replication by siRNAs directed against highly conserved HCV sequence and cellular HCV cofactors. J Hepatol. 2005;43:225-34 pubmed..A dual approach of direct- and cofactor-mediated inhibition of HCV replication might avoid selection of mutants and thereby become a powerful strategy against HCV. ..
- Luz N, Beck E. Interaction of a cellular 57-kilodalton protein with the internal translation initiation site of foot-and-mouth disease virus. J Virol. 1991;65:6486-94 pubmed..Results from footprint analyses with foot-and-mouth disease RNA suggest the participation of additional cellular factors in the translation initiation complex. ..
- Häcker S, Krebber H. Differential export requirements for shuttling serine/arginine-type mRNA-binding proteins. J Biol Chem. 2004;279:5049-52 pubmed..These findings suggest that Hrb1 and Gbp2, but not Npl3, might be loaded onto the growing mRNA via the THO complex components Mtf1 and Hrp1. ..
- Schrader R, Young C, Kozian D, Hoffmann R, Lottspeich F. Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway. J Biol Chem. 2006;281:35336-46 pubmed..Our data suggest that eIF5A mediates important cellular processes like cell viability and senescence through its effects on the stability of certain mRNAs. ..
- Asangani I, Rasheed S, Nikolova D, Leupold J, Colburn N, Post S, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene. 2008;27:2128-36 pubmed..This is the first study to show that Pdcd4 is negatively regulated by miR-21. Furthermore, it is the first report to demonstrate that miR-21 induces invasion/intravasation/metastasis. ..
- Hartmann C, Clayton C. Regulation of a transmembrane protein gene family by the small RNA-binding proteins TbUBP1 and TbUBP2. Mol Biochem Parasitol. 2008;157:112-5 pubmed..RNAi targeting TbUBP1 and 2 in bloodstream forms decreased mRNA with a 4110 3'-untranslated region, but increased it for 4080. Thus TbUBP and TbUBP2 may accentuate developmental regulation of the Tb927.3.4070-927.3.4110 mRNAs. ..
- Relógio A, Schwager C, Richter A, Ansorge W, Valcarcel J. Optimization of oligonucleotide-based DNA microarrays. Nucleic Acids Res. 2002;30:e51 pubmed..These data will facilitate the design and standardization of custom-made microarrays applicable to gene expression profiling and sequencing analyses. ..
- Bitomsky N, Böhm M, Klempnauer K. Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun. Oncogene. 2004;23:7484-93 pubmed..In addition to affecting c-Jun phosphorylation, Pdcd4 blocks the recruitment of the coactivator p300 by c-Jun. Taken together, our results strongly suggest that Pdcd4 is directly involved in the regulation of c-Jun activity. ..
- Buchhaupt M, Kötter P, Entian K. Mutations in the nucleolar proteins Tma23 and Nop6 suppress the malfunction of the Nep1 protein. FEMS Yeast Res. 2007;7:771-81 pubmed
- Oprea G, Kröber S, McWhorter M, Rossoll W, Muller S, Krawczak M, et al. Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy. Science. 2008;320:524-7 pubmed publisher..Our study suggests that defects in axonogenesis are the major cause of SMA, thereby opening new therapeutic options for SMA and similar neuromuscular diseases. ..
- Fischer T, Rodriguez Navarro S, Pereira G, Rácz A, Schiebel E, Hurt E. Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery. Nat Cell Biol. 2004;6:840-8 pubmed..A previously reported cdc31 temperature-sensitive allele, which is neither defective in SPB duplication nor Kic1 kinase activation, induces mRNA export defects. Thus, Cdc31 has an unexpected link to the mRNA export machinery. ..
- Görke B, Rak B. Catabolite control of Escherichia coli regulatory protein BglG activity by antagonistically acting phosphorylations. EMBO J. 1999;18:3370-9 pubmed..Thus, the PTS may represent a highly integrated signal transduction network in carbon catabolite control. ..
- Schulte F, Wieczorke R, Hollenberg C, Boles E. The HTR1 gene is a dominant negative mutant allele of MTH1 and blocks Snf3- and Rgt2-dependent glucose signaling in yeast. J Bacteriol. 2000;182:540-2 pubmed..The mutant forms block the transduction of the Snf3- and Rgt2-mediated glucose signals upstream of the Rgt1 transcriptional regulator. ..
- Jablonka S, Holtmann B, Meister G, Bandilla M, Rossoll W, Fischer U, et al. Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death. Proc Natl Acad Sci U S A. 2002;99:10126-31 pubmed..This finding correlates with enhanced motoneuron degeneration in Gemin2(+/-)/Smn(+/-) mice. Our data provide in vivo evidence that impaired production of U snRNPs contributes to motoneuron degeneration. ..
- Damianov A, Schreiner S, Bindereif A. Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP. Mol Cell Biol. 2004;24:1700-8 pubmed..With a U12-dependent in vitro splicing system, we demonstrate that p110 is required for recycling of the U4atac/U6atac snRNP. ..
- Nazlican H, Zeschnigk M, Claussen U, Michel S, Boehringer S, Gillessen Kaesbach G, et al. Somatic mosaicism in patients with Angelman syndrome and an imprinting defect. Hum Mol Genet. 2004;13:2547-55 pubmed..In conclusion, we suggest that the role of mosaic imprinting defects in mental retardation is underestimated. ..
- Hofmann W, Reichart B, Ewald A, Muller E, Schmitt I, Stauber R, et al. Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin. J Cell Biol. 2001;152:895-910 pubmed..In summary, our data provide evidence that actin plays an important functional role in nuclear export not only of retroviral RNAs but also of host proteins such as protein kinase inhibitor (PKI)...
- Haas M, Siegert M, Schürmann A, Sodeik B, Wolfes H. c-Myb protein interacts with Rcd-1, a component of the CCR4 transcription mediator complex. Biochemistry. 2004;43:8152-9 pubmed..The activation of the myeloid c-myb-specific mim-1 promoter is repressed by Rcd-1. Interestingly, rcd-1 is an erythropoietin regulated gene, which also represses the action of the AP-1 transcription factor on its target genes. ..
- Wirth B, Brichta L, Hahnen E. Spinal muscular atrophy and therapeutic prospects. Prog Mol Subcell Biol. 2006;44:109-32 pubmed..However, phase III double-blind placebo controlled clinical trials have to finally prove the efficacy of these drugs. ..
- Stoss O, Olbrich M, Hartmann A, Konig H, Memmott J, Andreadis A, et al. The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. J Biol Chem. 2001;276:8665-73 pubmed..Because the related protein of rSLM-2, Sam68, is believed to play a role as an adapter protein during signal transduction, we postulate that rSLM-2 is a link between signal transduction pathways and pre-mRNA processing. ..
- Yao W, Roser D, Köhler A, Bradatsch B, Bassler J, Hurt E. Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2. Mol Cell. 2007;26:51-62 pubmed..Thus, the general mRNA exporter Mex67-Mtr2 contains a distinct electrostatic interaction surface for transporting 60S preribosomal cargo. ..
- Wurm J, Meyer B, Bahr U, Held M, Frolow O, K tter P, et al. The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase. Nucleic Acids Res. 2010;38:2387-98 pubmed publisher..This enzymatic activity is also conserved in human Nep1 suggesting that Nep1 is the methyltransferase in the biosynthesis of m1acp3-Psi in eukaryotic 18S rRNAs...
- Chari A, Paknia E, Fischer U. The role of RNP biogenesis in spinal muscular atrophy. Curr Opin Cell Biol. 2009;21:387-93 pubmed publisher..The detailed biochemical investigation of SMN under normal conditions and in SMA has provided clues how mutations in factors with general functions elicit tissue-specific phenotypes. ..
- Jumaa H, Guenet J, Nielsen P. Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle. Mol Cell Biol. 1997;17:3116-24 pubmed..These motifs may be functional since reporter constructs with the SRp20 promoter can be stimulated by cotransfection with E2F expression plasmids. ..
- Trendelenburg G, Hummel M, Riecken E, Hanski C. Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain. Biochem Biophys Res Commun. 1996;225:313-9 pubmed..This domain together with the known characteristics of AKAPs suggests the involvement of AKAP149 in the phosphorylation-dependent regulation of RNA-processing. ..
- Doller A, Akool E, Huwiler A, Müller R, Radeke H, Pfeilschifter J, et al. Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. Mol Cell Biol. 2008;28:2608-25 pubmed publisher..Posttranslational modification of HuR by PKCdelta represents an important novel mode of HuR activation implied in renal COX-2 regulation. ..
- Kloss S, Srivastava R, Mülsch A. Down-regulation of soluble guanylyl cyclase expression by cyclic AMP is mediated by mRNA-stabilizing protein HuR. Mol Pharmacol. 2004;65:1440-51 pubmed..We conclude that forskolin/cAMP decrease the expression of heterodimeric sGC in rat aortic smooth muscle cells via activation of Fos/AP-1, which decreases the expression of HuR and thus destabilizes the sGCalpha1 and beta1 mRNA. ..
- Golas M, Sander B, Will C, Luhrmann R, Stark H. Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy. Mol Cell. 2005;17:869-83 pubmed..The manner in which SF3b is integrated in the U11/U12 di-snRNP has important implications for branch site recognition. Furthermore, a putative model of the pre-mRNA binding to the U11/U12 di-snRNP is proposed. ..
- Sharma C, Vogel J. Experimental approaches for the discovery and characterization of regulatory small RNA. Curr Opin Microbiol. 2009;12:536-46 pubmed publisher..We will also review the available toolbox for wet lab-based research, including in vivo and in vitro reporter systems, genetic methods and biochemical co-purification of sRNA interaction partners. ..
- Jumaa H, Wei G, Nielsen P. Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20. Curr Biol. 1999;9:899-902 pubmed..This is the first report of mice deficient for a member of the SR protein family. Our experiments confirm that, although similar in structure, the SR proteins are not functionally redundant...
- Gebauer F, Grskovic M, Hentze M. Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA. Mol Cell. 2003;11:1397-404 pubmed..These results elucidate a critical regulatory step for dosage compensation in Drosophila melanogaster. ..
- Jablonka S, Karle K, Sandner B, Andreassi C, von Au K, Sendtner M. Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy. Hum Mol Genet. 2006;15:511-8 pubmed..These data indicate that pathological alterations in severe forms of SMA are not restricted to motor neurons, but the defects in the sensory neurons are milder than those in the motor neurons. ..
- Busse M, Schwarzburger M, Berger F, Hacker C, Munz B. Strong induction of the Tis11B gene in myogenic differentiation. Eur J Cell Biol. 2008;87:31-8 pubmed..These data suggest that TIS11B is an important regulator of myogenesis. ..
- Novoyatleva T, Heinrich B, Tang Y, Benderska N, Butchbach M, Lorson C, et al. Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum Mol Genet. 2008;17:52-70 pubmed..Our data indicate that the binding of PP1 to evolutionary conserved motifs in several RRMs is the link between known signal transduction pathways regulating PP1 activity and pre-mRNA processing. ..
- Selenko P, Gregorovic G, Sprangers R, Stier G, Rhani Z, Kramer A, et al. Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP. Mol Cell. 2003;11:965-76 pubmed..This molecular recognition establishes a paradigm for protein binding by a subfamily of noncanonical RRMs. ..
- Heise T, Sommer G, Reumann K, Meyer I, Will H, Schaal H. The hepatitis B virus PRE contains a splicing regulatory element. Nucleic Acids Res. 2006;34:353-63 pubmed..We discuss a model in which the regulation of pgRNA splicing depends on cellular factors interacting with the PRE. ..
- Klinkert B, Elles I, Nickelsen J. Translation of chloroplast psbD mRNA in Chlamydomonas is controlled by a secondary RNA structure blocking the AUG start codon. Nucleic Acids Res. 2006;34:386-94 pubmed..In conclusion, the data suggest that these new element serves as a negative regulator which mediates a rapid shut-down of D2 synthesis. ..
- Nayler O, Cap C, Stamm S. Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform. Genomics. 1998;53:191-202 pubmed..Finally, we show that htra2-beta3 is expressed in the nucleus and interacts with a subset of SR proteins in a yeast two-hybrid system and in vivo. ..
- Fortes P, Bilbao Cortes D, Fornerod M, Rigaut G, Raymond W, Seraphin B, et al. Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition. Genes Dev. 1999;13:2425-38 pubmed..These data suggest that the loss of Luc7p disrupts U1 snRNP-CBC interaction, and that this interaction contributes to normal 5' splice site recognition. ..
- Galani K, Grosshans H, Deinert K, Hurt E, Simos G. The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p. EMBO J. 2001;20:6889-98 pubmed..We suggest that the organization of aminoacyl-tRNA synthetases into a multimeric complex not only affects catalysis, but is also a means of segregating the tRNA- aminoacylation machinery mainly to the cytoplasmic compartment. ..
- Barth S, Liss M, Voss M, Dobner T, Fischer U, Meister G, et al. Epstein-Barr virus nuclear antigen 2 binds via its methylated arginine-glycine repeat to the survival motor neuron protein. J Virol. 2003;77:5008-13 pubmed
- Hägele S, Kuhn U, Böning M, Katschinski D. Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression. Biochem J. 2009;417:235-46 pubmed publisher..Thus CPEB1 and CPEB2 are involved in the regulation of HIF-1alpha following insulin stimulation. ..
- Senger B, Simos G, Bischoff F, Podtelejnikov A, Mann M, Hurt E. Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p. EMBO J. 1998;17:2196-207 pubmed..This suggests that Npl3p follows a distinct nuclear import pathway and that intranuclear release from its specific import receptor Mtr10p requires the cooperative action of both Ran-GTP and newly synthesized mRNA. ..
- Monshausen M, Rehbein M, Richter D, Kindler S. The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1. J Neurochem. 2002;81:557-64 pubmed..Cellular functions of Staufen may be regulated via phosphorylation or Staufen may recruite the phosphatase into specific ribonucleoprotein complexes. ..
- Macchi P, Kroening S, Palacios I, Baldassa S, Grunewald B, Ambrosino C, et al. Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner. J Neurosci. 2003;23:5778-88 pubmed..Together, our data suggest that the mRNA transport machinery is conserved during evolution, and that mammalian Btz is an additional component of the dendritic RNPs in hippocampal neurons. ..
- Reiser G, Bernstein H. Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin. Neuroreport. 2004;15:147-8 pubmed..Meanwhile, specific interaction of p42IP4 with nucleolin, another player in AD pathology, has been revealed. Based on these data, we propose alternative concepts of how p42IP4 might act in AD pathomechanisms. ..
- Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann A, Brack Werner R, et al. The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation. Hum Mol Genet. 2004;13:1535-49 pubmed..We propose that tyrosine phosphorylation causes sequestration of YT521-B in an insoluble nuclear form, which abolishes the ability of YT521-B to change alternative splice sites. ..
- Reichenbach B, Breustedt D, Stülke J, Rak B, Görke B. Genetic dissection of specificity determinants in the interaction of HPr with enzymes II of the bacterial phosphoenolpyruvate:sugar phosphotransferase system in Escherichia coli. J Bacteriol. 2007;189:4603-13 pubmed..Therefore, they may constitute a signature motif that determines the specificity of HPr for either gram-negative or -positive EIIs. ..
- Lankat Buttgereit B, Lenschen B, Schmidt H, Göke R. The action of Pdcd4 may be cell type specific: evidence that reduction of dUTPase levels might contribute to its tumor suppressor activity in Bon-1 cells. Apoptosis. 2008;13:157-64 pubmed..Therefore, we conclude that the function of Pdcd4 might be cell type specific. A role for Pdcd4 in apoptosis or as a tumor suppressor might be limited to certain cell types. ..
- Körner C, Wahle E. Poly(A) tail shortening by a mammalian poly(A)-specific 3'-exoribonuclease. J Biol Chem. 1997;272:10448-56 pubmed..The properties of DAN suggest that the enzyme might be involved in the deadenylation of mRNA in vivo. ..
- Young J, Obermann W, Hartl F. Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. J Biol Chem. 1998;273:18007-10 pubmed..In reticulocyte lysate, the C90 fusion protein recognized the TPR proteins p60, FKBP52, and Cyp40. Thus, our results identify the C90 domain as the specific binding site for a set of hsp90 cofactors having TPR domains. ..
- Lankat Buttgereit B, Göke R. Programmed cell death protein 4 (pdcd4): a novel target for antineoplastic therapy?. Biol Cell. 2003;95:515-9 pubmed..These features implicate a potential value of Pdcd4 as a molecular target in cancer therapy. This review summarizes the current knowledge about expression, structure and function of Pdcd4. ..
- Wiegand M, Bossow S, Neubert W. Sendai virus trailer RNA simultaneously blocks two apoptosis-inducing mechanisms in a cell type-dependent manner. J Gen Virol. 2005;86:2305-14 pubmed..Thus, virus-expressed factors enabling a well-balanced ratio of suppression and triggering of apoptosis seem to be essential for optimal virus replication. ..
- Oddone A, Lorentzen E, Basquin J, Gasch A, Rybin V, Conti E, et al. Structural and biochemical characterization of the yeast exosome component Rrp40. EMBO Rep. 2007;8:63-9 pubmed..The affinity of an archaeal core exosome for RNA is significantly increased in the presence of the S1-KH subunit Rrp4, indicating that multiple subunits might contribute to cooperative binding of RNA substrates by the exosome. ..
- Höck J, Weinmann L, Ender C, Rüdel S, Kremmer E, Raabe M, et al. Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep. 2007;8:1052-60 pubmed..Using reporter assays and knockdown experiments, we showed that the putative RNA-binding protein RBM4 is required for microRNA-guided gene regulation. ..
- Penalva L, Lallena M, Valcarcel J. Switch in 3' splice site recognition between exon definition and splicing catalysis is important for sex-lethal autoregulation. Mol Cell Biol. 2001;21:1986-96 pubmed
- Sprangers R, Groves M, Sinning I, Sattler M. High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues. J Mol Biol. 2003;327:507-20 pubmed..The observed structural variations may play a role for the recognition of sDMAs. ..
- Chen Y, Knösel T, Kristiansen G, Pietas A, Garber M, Matsuhashi S, et al. Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. J Pathol. 2003;200:640-6 pubmed..These data suggest that the loss of PDCD4 expression is a prognostic factor in lung cancer and may correlate with tumour progression. ..
- Zhang S, Schlott B, Görlach M, Grosse F. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. Nucleic Acids Res. 2004;32:1-10 pubmed..These results support the view that DNA-PK can also function as an RNA-dependent protein kinase to regulate some aspects of RNA metabolism, such as RNA processing and transport. ..
- Bredemeier R, Schlegel T, Ertel F, Vojta A, Borissenko L, Bohnsack M, et al. Functional and phylogenetic properties of the pore-forming beta-barrel transporters of the Omp85 family. J Biol Chem. 2007;282:1882-90 pubmed..Based on functional and phylogenetic analysis, we suggest an evolutionary scenario that explains the origin of the contemporary translocon. ..
- Falley K, Schütt J, Iglauer P, Menke K, Maas C, Kneussel M, et al. Shank1 mRNA: dendritic transport by kinesin and translational control by the 5'untranslated region. Traffic. 2009;10:844-57 pubmed publisher..A concept emerges from our data in which dendritic transport of different mRNAs occurs collectively via a staufen1- and KIF5-dependent pathway, whereas their local translation is controlled individually by unique cis-acting elements. ..
- Simader H, Hothorn M, Köhler C, Basquin J, Simos G, Suck D. Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes. Nucleic Acids Res. 2006;34:3968-79 pubmed..The results demonstrate a novel role for this fold as a heteromerization domain specific to eukaryotic aaRS, associated proteins and protein translation elongation factors. ..
- Pena V, Liu S, Bujnicki J, Luhrmann R, Wahl M. Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa. Mol Cell. 2007;25:615-24 pubmed..We conclude that the expanded Prp8 Jab1/MPN domain represents a pseudoenzyme converted into a protein-protein interaction platform and that dysfunction of this platform underlies Retinitis pigmentosa. ..
- Zell R, Ihle Y, Seitz S, Gündel U, Wutzler P, Görlach M. Poly(rC)-binding protein 2 interacts with the oligo(rC) tract of coxsackievirus B3. Biochem Biophys Res Commun. 2008;366:917-21 pubmed..In the presence of 3C proteinase, cloverleaf RNA (1-87) interacts with PCBP2. ..
- Steller U, Kohls S, Muller B, Soller R, Muller R, Schlender J, et al. The RNA binding protein HuD: rat cDNA and analysis of the alternative spliced mRNA in neuronal differentiating cell lines P19 and PC12. Brain Res Mol Brain Res. 1996;35:285-96 pubmed..This RNA processing event seems to be differently regulated in PC12 cells on the one hand, and in P19 cells and brain of rat and mouse on the other. ..
- Buhler D, Raker V, Luhrmann R, Fischer U. Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy. Hum Mol Genet. 1999;8:2351-7 pubmed..Thus, our data show that SMN is an essential U snRNP assembly factor and establish a direct correlation between defects in the biogenesis of U snRNPs and SMA. ..
- Straub T, Knudsen B, Boege F. PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices. Biochemistry. 2000;39:7552-8 pubmed..Thus, stimulation of topoisomerase I catalysis by PSF/p54(nrb) seems to be affected by mobilization of the enzyme. ..
- Brabeck C, Michetti F, Geloso M, Corvino V, Goezalan F, Meyermann R, et al. Expression of EMAP-II by activated monocytes/microglial cells in different regions of the rat hippocampus after trimethyltin-induced brain damage. Exp Neurol. 2002;177:341-6 pubmed..Thus, upregulation of EMAP-II by activated monocytes/microglial cells may serve as a sensitive marker of neurotoxic lesions in the rat brain. ..
- Mühlberger R, Robelek R, Eisenreich W, Ettenhuber C, Sinner E, Kessler H, et al. RNA DNA discrimination by the antitermination protein NusB. J Mol Biol. 2003;327:973-83 pubmed..The impact of structural modification of the boxA motif on the affinity for NusB protein as observed by 1H15N heterocorrelation was analysed by a generic algorithm. ..
- Luetjens C, Xu E, Rejo Pera R, Kamischke A, Nieschlag E, Gromoll J. Association of meiotic arrest with lack of BOULE protein expression in infertile men. J Clin Endocrinol Metab. 2004;89:1926-33 pubmed..Thus, the spermatogenic damage leading to meiotic arrest is independent of the etiology and indicates that BOULE is a possible fundamental mediator of meiotic transition in the human. ..
- Macchi P, Brownawell A, Grunewald B, DesGroseillers L, Macara I, Kiebler M. The brain-specific double-stranded RNA-binding protein Staufen2: nucleolar accumulation and isoform-specific exportin-5-dependent export. J Biol Chem. 2004;279:31440-4 pubmed..It is tempting to speculate that Stau2(62) binds RNA in the nucleus and assembles into ribonucleoparticles, which are then exported via the Exportin-5 pathway to their final destination. ..
- Morth J, Feng V, Perry L, Svergun D, Tucker P. The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis. Structure. 2004;12:1595-605 pubmed
- Linker K, Pautz A, Fechir M, Hubrich T, Greeve J, Kleinert H. Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. Nucleic Acids Res. 2005;33:4813-27 pubmed..Finally, a complex interplay of KSRP with TTP and HuR seems to be essential for iNOS mRNA stabilization after cytokine stimulation. ..
- Simader H, Suck D. Expression, purification, crystallization and preliminary phasing of the heteromerization domain of the tRNA-export and aminoacylation cofactor Arc1p from yeast. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:346-9 pubmed..8 angstroms resolution. Preliminary phasing reveals the presence of 20 monomers organized in five tetramers per asymmetric unit. ..
- Kostova E, Yeung C, Luetjens C, Brune M, Nieschlag E, Gromoll J. Association of three isoforms of the meiotic BOULE gene with spermatogenic failure in infertile men. Mol Hum Reprod. 2007;13:85-93 pubmed..Among the three isoforms, B2 might have the major role for meiotic completion. ..
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