Experts and Doctors on ribonucleases in France


Locale: France
Topic: ribonucleases

Top Publications

  1. Dev A, Horak J, Kaiser A, Yuan X, Perols A, Björk P, et al. Electrokinetic effect for molecular recognition: A label-free approach for real-time biosensing. Biosens Bioelectron. 2016;82:55-63 pubmed publisher
  2. Anquetil V, Le Sommer C, Mereau A, Hamon S, Lerivray H, Hardy S. Polypyrimidine tract binding protein prevents activity of an intronic regulatory element that promotes usage of a composite 3'-terminal exon. J Biol Chem. 2009;284:32370-83 pubmed publisher
    ..This result suggests that a non-stop decay mechanism participates in the strict control of the 3'-end processing of the alpha-tropomyosin pre-mRNA. ..
  3. Lefaucheur L, Ecolan P, Plantard L, Gueguen N. New insights into muscle fiber types in the pig. J Histochem Cytochem. 2002;50:719-30 pubmed
    ..The developmental origin and functional significance of the type grouping distribution are discussed. ..
  4. Wallaert B, Gosset P, Lamblin C, Garcia G, Perez T, Tonnel A. Airway neutrophil inflammation in nonasthmatic patients with food allergy. Allergy. 2002;57:405-10 pubmed
    ..Our results demonstrate that a subclinical neutrophil airway inflammation is present in patients with food allergy free of clinical respiratory symptoms and that IL-8 may be an important mediator of this neutrophilia. ..
  5. Tonduti D, Orcesi S, Jenkinson E, Dorboz I, Renaldo F, Panteghini C, et al. Clinical, radiological and possible pathological overlap of cystic leukoencephalopathy without megalencephaly and Aicardi-Goutières syndrome. Eur J Paediatr Neurol. 2016;20:604-10 pubmed publisher
    ..Our data highlight the need to include both disorders in the same differential diagnosis, and hint at possible shared pathomechanisms related to auto-inflammation which are worthy of further investigation. ..
  6. Bergoin C, Gosset P, Lamblin C, Bolard F, Turck D, Tonnel A, et al. Cell and cytokine profile in nasal secretions in cystic fibrosis. J Cyst Fibros. 2002;1:110-5 pubmed
    ..IL-8 and IL-5 may play crucial roles in recruitment and activation of neutrophils and eosinophils in upper airways of CF patients. ..
  7. Rojas Ríos P, Chartier A, Pierson S, Simonelig M. Aubergine and piRNAs promote germline stem cell self-renewal by repressing the proto-oncogene Cbl. EMBO J. 2017;36:3194-3211 pubmed publisher
    ..This study reveals the role of piRNAs and PIWI proteins in controlling stem cell homeostasis via translational repression and highlights piRNAs as major post-transcriptional regulators in key developmental decisions. ..
  8. Debray H, Coddeville B, Bomfim L, Ramos M. A simple micro-method for determining precise oligosaccharidic specificity of mannose-binding lectins. Glycobiology. 2009;19:1417-26 pubmed publisher
  9. Gasciolli V, Mallory A, Bartel D, Vaucheret H. Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs. Curr Biol. 2005;15:1494-500 pubmed

More Information


  1. Grechez Cassiau A, Panda S, Lacoche S, Teboul M, Azmi S, Laudet V, et al. The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs. J Biol Chem. 2004;279:1141-50 pubmed
    ..These biochemical and genetic data establish a role for the basic helix-loop-helix repressor STRA13 as a circadian output regulator in the periphery. ..
  2. Daugeron M, Mauxion F, Seraphin B. The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation. Nucleic Acids Res. 2001;29:2448-55 pubmed
    ..Altogether, our study indicates that Pop2p is a nuclease subunit of the yeast deadenylase and suggests that Pop2p homologues in other species may have similar functions. ..
  3. Maes P, Damart D, Rommens C, Montreuil J, Spik G, Tartar A. The complete amino acid sequence of bovine milk angiogenin. FEBS Lett. 1988;241:41-5 pubmed
    ..The sequence of bovine angiogenin contains the cell recognition tripeptide Arg-Gly-Asp which is not present in the human protein. ..
  4. Dupressoir A, Barbot W, Loireau M, Heidmann T. Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion. J Biol Chem. 1999;274:31068-75 pubmed
    ..The strong amino acid conservation between the human, murine, and the previously identified Xenopus CCR4-like proteins, is consistent with an important and conserved role for this protein in vertebrates. ..
  5. Moissiard G, Parizotto E, Himber C, Voinnet O. Transitivity in Arabidopsis can be primed, requires the redundant action of the antiviral Dicer-like 4 and Dicer-like 2, and is compromised by viral-encoded suppressor proteins. RNA. 2007;13:1268-78 pubmed
    ..Finally, we show that target cleavage by a primary small RNA and 3-->5' transitivity can be genetically uncoupled, and we provide in vivo evidence supporting a key role for priming in this specific reaction. ..
  6. Kolb F, Westhof E, Ehresmann C, Ehresmann B, Wagner E, Romby P. Bulged residues promote the progression of a loop-loop interaction to a stable and inhibitory antisense-target RNA complex. Nucleic Acids Res. 2001;29:3145-53 pubmed
    ..In contrast to the four-way junction topology, the loop-loop interaction alone failed to prevent ribosome binding at its loading site and, thus, inhibition of RepA translation was alleviated. ..
  7. Phung D, Rinaldi D, Langendijk Genevaux P, Quentin Y, Carpousis A, Clouet d Orval B. Archaeal ?-CASP ribonucleases of the aCPSF1 family are orthologs of the eukaryal CPSF-73 factor. Nucleic Acids Res. 2013;41:1091-103 pubmed publisher
    ..Altogether, our results suggest that aCPSF1 performs an essential function and that an enzyme with similar activities was present in the last common ancestor of Archaea and Eukarya. ..
  8. Dielen A, Sassaki F, Walter J, Michon T, Ménard G, Pagny G, et al. The 20S proteasome ?5 subunit of Arabidopsis thaliana carries an RNase activity and interacts in planta with the lettuce mosaic potyvirus HcPro protein. Mol Plant Pathol. 2011;12:137-50 pubmed publisher
    ..Taken together, these results extend to A. thaliana ?(5) the range of HcPro-interacting proteasomal subunits, and suggest that HcPro may modulate its associated RNase activity which may contribute to an antiviral response. ..
  9. Loiselay C, Gumpel N, Girard Bascou J, Watson A, Purton S, Wollman F, et al. Molecular identification and function of cis- and trans-acting determinants for petA transcript stability in Chlamydomonas reinhardtii chloroplasts. Mol Cell Biol. 2008;28:5529-42 pubmed publisher
    ..Conversely, TCA1 participates to the full stabilization of the transcript through its interaction with MCA1. ..
  10. Prevot D, Morel A, Voeltzel T, Rostan M, Rimokh R, Magaud J, et al. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. J Biol Chem. 2001;276:9640-8 pubmed
    ..In addition, our results indicate that two LXXLL motifs, referred to as nuclear receptor boxes, present in both BTG1 and BTG2, are involved in the regulation of ERalpha-mediated activation. ..
  11. Zaessinger S, Busseau I, Simonelig M. Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4. Development. 2006;133:4573-83 pubmed
    ..This study provides insights into molecular mechanisms of regulated deadenylation by specific proteins and demonstrates its importance in development. ..
  12. Finoux A, Seraphin B. In vivo targeting of the yeast Pop2 deadenylase subunit to reporter transcripts induces their rapid degradation and generates new decay intermediates. J Biol Chem. 2006;281:25940-7 pubmed
    ..Furthermore, deadenylase recruitment affects the downstream path of mRNA decay. ..
  13. Benoit B, Mitou G, Chartier A, Temme C, Zaessinger S, Wahle E, et al. An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila. Dev Cell. 2005;9:511-22 pubmed
    ..Both Cyclin B protein levels and embryonic development depend upon this regulation. These results identify a regulator of maternal mRNA poly(A) tail length and highlight the importance of this mode of translational control. ..
  14. Ballut L, Drucker M, Pugniere M, Cambon F, Blanc S, Roquet F, et al. HcPro, a multifunctional protein encoded by a plant RNA virus, targets the 20S proteasome and affects its enzymic activities. J Gen Virol. 2005;86:2595-603 pubmed
  15. Jauneau A, Ischenko A, Chan P, Fontaine M. Complement component anaphylatoxins upregulate chemokine expression by human astrocytes. FEBS Lett. 2003;537:17-22 pubmed
    ..Thus, anaphylatoxins could initiate a chemokine cascade and, at least in part, be involved in pathogenesis of the brain. ..
  16. Castella S, Bénédetti H, de Llorens R, Dacheux J, Dacheux F. Train A, an RNase A-like protein without RNase activity, is secreted and reabsorbed by the same epididymal cells under testicular control. Biol Reprod. 2004;71:1677-87 pubmed
    ..This new compound might therefore participate in an unknown function in the epithelial cells of this first part of the epididymis by an autocrine pathway. ..
  17. Grandin N, Charbonneau M. Dbf2 is implicated in a Cbt1-dependent pathway following a shift from glucose to galactose or non-fermentable carbon sources in Saccharomyces cerevisiae. Mol Gen Genet. 1999;261:402-7 pubmed
    ..Therefore, Dbf2 may be required not only during mitosis but also during growth on non-fermentable carbon sources. ..
  18. Gallouzi I, Parker F, Chebli K, Maurier F, Labourier E, Barlat I, et al. A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability. Mol Cell Biol. 1998;18:3956-65 pubmed
    ..The endoribonuclease activity of G3BP can initiate mRNA degradation and therefore represents a link between a RasGAP-mediated signaling pathway and RNA turnover. ..
  19. Myslinski E, Branlant C. A phylogenetic study of U4 snRNA reveals the existence of an evolutionarily conserved secondary structure corresponding to 'free' U4 snRNA. Biochimie. 1991;73:17-28 pubmed
    ..In this domain, only the Sm binding site and the presence of a bulge nucleotide in the hairpin on the 5' side of the Sm site are conserved throughout evolution...
  20. Mordier S, Bechet D, Roux M, Obled A, Ferrara M. Nucleotide sequence of bovine preprocathepsin B. A study of polymorphism in the protein coding region. Biochim Biophys Acta. 1993;1174:305-11 pubmed
    ..We conclude that sequence polymorphism in bovine cathepsin B is a rare event, and can only result from the expression of different alleles of a unique gene. ..
  21. Bayard B, Bette Bobillo P, Aliau S. Affinity purification and characterization of (2'-5')oligo(adenylate)-dependent RNase from mouse spleen. Eur J Biochem. 1994;223:403-10 pubmed