Experts and Doctors on reverse transcriptase polymerase chain reaction in Netherlands


Locale: Netherlands
Topic: reverse transcriptase polymerase chain reaction

Top Publications

  1. Dik W, Pike Overzet K, Weerkamp F, de Ridder D, de Haas E, Baert M, et al. New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med. 2005;201:1715-23 pubmed
    ..Our data demonstrate that a number of key events occur earlier than assumed previously; therefore, human T cell development is much more similar to murine T cell development than reported before. ..
  2. Sta M, Sylva Steenland R, Casula M, de Jong J, Troost D, Aronica E, et al. Innate and adaptive immunity in amyotrophic lateral sclerosis: evidence of complement activation. Neurobiol Dis. 2011;42:211-20 pubmed publisher
    ..We propose a complement-driven immune response which may contribute to the progression of the inflammation and ultimately lead to even more motor neuron injury. ..
  3. Westra J, Limburg P, de Boer P, van Rijswijk M. Effects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts. Ann Rheum Dis. 2004;63:1453-9 pubmed
    ..01 microM RWJ 67657. RWJ 67657 inhibits major proinflammatory mediator production in stimulated RSF at pharmacologically relevant concentrations. These findings could have important relevance for the treatment of rheumatoid arthritis. ..
  4. Passier R, Oostwaard D, Snapper J, Kloots J, Hassink R, Kuijk E, et al. Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures. Stem Cells. 2005;23:772-80 pubmed
    ..The present data provide a step in this direction and represent an improved in vitro model, without interfering factors in serum, for testing other factors that might promote cardiomyocyte differentiation. ..
  5. Kamphuis W, Hendriksen H. Expression patterns of voltage-dependent calcium channel alpha 1 subunits (alpha 1A-alpha 1E) mRNA in rat retina. Brain Res Mol Brain Res. 1998;55:209-20 pubmed
  6. Boddeke E, Meigel I, Frentzel S, Biber K, Renn L, Gebicke Härter P. Functional expression of the fractalkine (CX3C) receptor and its regulation by lipopolysaccharide in rat microglia. Eur J Pharmacol. 1999;374:309-13 pubmed
    ..It is concluded that treatment with endotoxin downregulates expression of fractalkine receptor mRNA in rat microglia and suppresses the functional response to fractalkine. ..
  7. van Bezooijen R, Roelen B, Visser A, van der Wee Pals L, de Wilt E, Karperien M, et al. Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med. 2004;199:805-14 pubmed
    ..Its unique localization and action on osteoblasts suggest that sclerostin may be the previously proposed osteocyte-derived factor that is transported to osteoblasts at the bone surface and inhibits bone formation. ..
  8. Wesseling S, Joles J, van Goor H, Bluyssen H, Kemmeren P, Holstege F, et al. Transcriptome-based identification of pro- and antioxidative gene expression in kidney cortex of nitric oxide-depleted rats. Physiol Genomics. 2007;28:158-67 pubmed
    ..Interaction between NO synthesis and heme degradation pathways for blood pressure regulation was not found...
  9. W sten M, van Dijk L, Parker C, Guilhabert M, van der Meer Janssen Y, Wagenaar J, et al. Growth phase-dependent activation of the DccRS regulon of Campylobacter jejuni. J Bacteriol. 2010;192:2729-36 pubmed publisher
    ..Whole-genome mRNA profiling and real-time RT-PCR analysis under these conditions demonstrated that the system has no influence on the transcription of genes outside the DccRS regulon...

More Information


  1. van der Veen S, Abee T. Importance of SigB for Listeria monocytogenes static and continuous-flow biofilm formation and disinfectant resistance. Appl Environ Microbiol. 2010;76:7854-60 pubmed publisher
  2. Groeneweg J, Ummels A, Mulder M, Bikker H, van der Smagt J, van Mil A, et al. Functional assessment of potential splice site variants in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm. 2014;11:2010-7 pubmed publisher
    ..These results highlight the importance of functional assessment of potential splice site variants to improve patient care and facilitate cascade screening. ..
  3. Yu Z, Liu J, van Veldhoven J, Ijzerman A, Schalij M, Pijnappels D, et al. Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias. Circ Arrhythm Electrophysiol. 2016;9:e003439 pubmed publisher
    ..1 blockers via pharmacological combination therapy. ..
  4. Jensen T, van de Bildt M, Dietz H, Andersen T, Hammer A, Kuiken T, et al. Another phocine distemper outbreak in Europe. Science. 2002;297:209 pubmed
  5. Bonifati V, Rizzu P, van Baren M, Schaap O, Breedveld G, Krieger E, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 2003;299:256-9 pubmed
    ..Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease. ..
  6. Jacobs C, van der Zee M. Immune competence in insect eggs depends on the extraembryonic serosa. Dev Comp Immunol. 2013;41:263-9 pubmed publisher
    ..Drosophila eggs and serosa-less Tribolium eggs, however, show little to no upregulation of any of the tested immune genes. We conclude that the extraembryonic serosa is crucial for the early immune competence of the Tribolium egg...