Experts and Doctors on rev gene products in Germany


Locale: Germany
Topic: rev gene products

Top Publications

  1. Brandt S, Blissenbach M, Grewe B, Konietzny R, Grunwald T, Uberla K. Rev proteins of human and simian immunodeficiency virus enhance RNA encapsidation. PLoS Pathog. 2007;3:e54 pubmed
    ..In addition to specific interactions of nucleocapsid with the packaging signal at the 5' end of the genome, the Rev/RRE system provides a second mechanism contributing to preferential encapsidation of genomic lentiviral RNA. ..
  2. Neumann M, Afonina E, Ceccherini Silberstein F, Schlicht S, Erfle V, Pavlakis G, et al. Nucleocytoplasmic transport in human astrocytes: decreased nuclear uptake of the HIV Rev shuttle protein. J Cell Sci. 2001;114:1717-29 pubmed
    ..Our studies suggest a model in which Rev is prevented from functioning efficiently in astrocytes by specific alterations of its nucleocytoplasmic trafficking properties. ..
  3. Wodrich H, Bohne J, Gumz E, Welker R, Krausslich H. A new RNA element located in the coding region of a murine endogenous retrovirus can functionally replace the Rev/Rev-responsive element system in human immunodeficiency virus type 1 Gag expression. J Virol. 2001;75:10670-82 pubmed
    ..There was no overall homology between the IAPE and the CTE, but there was complete sequence identity between short putative single-stranded loops. Deletion of these loops from the IAPE severely reduced Rev-independent Gag expression. ..
  4. Wolff H, Brack Werner R, Neumann M, Werner T, Schneider R. Integrated functional and bioinformatics approach for the identification and experimental verification of RNA signals: application to HIV-1 INS. Nucleic Acids Res. 2003;31:2839-51 pubmed
    ..Inhibitory activity increased by combining both INS regions in the same mRNA. Inhibitory activity of known and new INS regions was overcome by co-expression of the HIV-1 Rev protein. ..
  5. Lucke S, Grunwald T, Uberla K. Reduced mobilization of Rev-responsive element-deficient lentiviral vectors. J Virol. 2005;79:9359-62 pubmed
    ..Thus, RRE-deficient lentiviral vectors provide a novel approach to reduce the risk of vector mobilization. ..
  6. Lower R, Tönjes R, Korbmacher C, Kurth R, Lower J. Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K. J Virol. 1995;69:141-9 pubmed
    ..Secondary structure analysis reveals similarities to basic helix-loop-helix proteins. cORF is a small protein with an apparent molecular mass of 14 kDa which accumulates in the nucleolus as has been described for Rev proteins. ..
  7. Schatz O, Oft M, Dascher C, Schebesta M, Rosorius O, Jaksche H, et al. Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5. Proc Natl Acad Sci U S A. 1998;95:1607-12 pubmed
    ..Our data suggest that the Rev export pathway shares components of a cellular transport system involved in the intracellular trafficking of polymerase III (5S rRNA) transcripts. ..
  8. Fischer U, Pollard V, Luhrmann R, Teufel M, Michael M, Dreyfuss G, et al. Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle. Nucleic Acids Res. 1999;27:4128-34 pubmed
    ..Finally, we demonstrate that Rev/RRE-activated RNA export is, like other nuclear export pathways, linked to the Ran-GTPase cycle. ..
  9. Ristea S, Dobbelstein M, Roth J. Rev protein of human immunodeficiency virus type 1 and cellular exportin 1 protein relocalize each other to a subnucleolar structure. AIDS Res Hum Retroviruses. 2000;16:857-65 pubmed
    ..Thus, an excess of exportin 1 may downregulate Rev-mediated RNA export by sequestering Rev to a subnucleolar structure. ..

More Information


  1. Wagner R, Graf M, Bieler K, Wolf H, Grunwald T, Foley P, et al. Rev-independent expression of synthetic gag-pol genes of human immunodeficiency virus type 1 and simian immunodeficiency virus: implications for the safety of lentiviral vectors. Hum Gene Ther. 2000;11:2403-13 pubmed
    ..By eliminating regions of homology and sequences involved in packaging, synthetic gag-pol genes should improve the safety profile of lentiviral vectors. ..
  2. Hofmann W, Reichart B, Ewald A, Muller E, Schmitt I, Stauber R, et al. Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin. J Cell Biol. 2001;152:895-910 pubmed
    ..In summary, our data provide evidence that actin plays an important functional role in nuclear export not only of retroviral RNAs but also of host proteins such as protein kinase inhibitor (PKI)...
  3. Magin Lachmann C, Hahn S, Strobel H, Held U, Lower J, Lower R. Rec (formerly Corf) function requires interaction with a complex, folded RNA structure within its responsive element rather than binding to a discrete specific binding site. J Virol. 2001;75:10359-71 pubmed
    ..Finally, we demonstrate that both Rev and Rex can mediate nuclear export through the RcRE but that their binding sites are different from each other and from that of Rec. ..
  4. Kramer Hammerle S, Ceccherini Silberstein F, Bickel C, Wolff H, Vincendeau M, Werner T, et al. Identification of a novel Rev-interacting cellular protein. BMC Cell Biol. 2005;6:20 pubmed
    ..4.1 may act as a modulator of Rev activity. The experimental strategies outlined in this study are applicable to the identification and biological characterization of further novel Rev-interacting cellular factors. ..
  5. Arnold M, Nath A, Hauber J, Kehlenbach R. Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. J Biol Chem. 2006;281:20883-90 pubmed
    ..Taken together, the viral protein takes advantage of multiple cellular transport pathways for its nuclear accumulation. ..