Experts and Doctors on reproducibility of results in Finland


Locale: Finland
Topic: reproducibility of results

Top Publications

  1. Koskenkorva P, Niskanen E, Hyppönen J, Kononen M, Mervaala E, Soininen H, et al. Sensorimotor, visual, and auditory cortical atrophy in Unverricht-Lundborg disease mapped with cortical thickness analysis. AJNR Am J Neuroradiol. 2012;33:878-83 pubmed publisher
    ..Cortical thinning in the sensorimotor areas in EPM1 correlated significantly with the degree of the severity of the myoclonus and is most likely related to the widespread stimulus sensitivity in EPM1. ..
  2. Siggins S, Kärkkäinen M, Tenhunen J, Metso J, Tahvanainen E, Olkkonen V, et al. Quantitation of the active and low-active forms of human plasma phospholipid transfer protein by ELISA. J Lipid Res. 2004;45:387-95 pubmed
    ..The HA-PLTP mass (mean, 1.87 +/- 0.85 mg/l) correlated significantly with serum PLTP activity, whereas that of LA-PLTP (mean, 3.94 +/- 1.4 mg/l) showed no correlation with phospholipid transfer activity. ..
  3. Kaasinen V, Aalto S, Någren K, Rinne J. Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease. Mov Disord. 2004;19:1348-51 pubmed
    ..The results provide further support for a relationship between novelty seeking and insular D2 receptors. They indicate that the association is cross-cultural, independent of age, and unaffected by dopaminergic degeneration. ..
  4. Loisa P, Uusaro A, Ruokonen E. A single adrenocorticotropic hormone stimulation test does not reveal adrenal insufficiency in septic shock. Anesth Analg. 2005;101:1792-8 pubmed
    ..401; P = 0.080). We conclude that the results of the ACTH stimulation tests are poorly reproducible in septic shock and a single ACTH stimulation test may not be the best method to diagnose adrenal insufficiency in these patients. ..
  5. Sormaala M, Ruohola J, Mattila V, Koskinen S, Pihlajamaki H. Comparison of 1.5T and 3T MRI scanners in evaluation of acute bone stress in the foot. BMC Musculoskelet Disord. 2011;12:128 pubmed publisher
    ..5T and 3T images to bone marrow edema. Routine identification of acute bone stress changes and suspected stress injuries can, therefore, be made with 1.5T field strength. ..
  6. Seppänen K, Kauppila T, Pitkälä K, Kautiainen H, Puustinen R, Iivanainen A, et al. Altering a computerized laboratory test order form rationalizes ordering of laboratory tests in primary care physicians. Int J Med Inform. 2016;86:49-53 pubmed publisher
    ..Removing a laboratory test from a computerized laboratory test order form may significantly reduce GPs' use of the laboratory test. Further studies are needed, however, to ensure the safety of this type of intervention. ..
  7. Juutilainen J, Huuskonen H, Komulainen H. Increased resorptions in CBA mice exposed to low-frequency magnetic fields: an attempt to replicate earlier observations. Bioelectromagnetics. 1997;18:410-7 pubmed
    ..The results demonstrate that animal strain is an important variable in bioelectromagnetics research: even closely related strains may show different responses to magnetic field exposure. ..
  8. Koobi T, Kahonen M, Iivainen T, Turjanmaa V. Simultaneous non-invasive assessment of arterial stiffness and haemodynamics - a validation study. Clin Physiol Funct Imaging. 2003;23:31-6 pubmed
    ..The method is highly repeatable and reproducible. ..
  9. Syed P, Gidwani K, Kekki H, Leivo J, Pettersson K, Lamminmaki U. Role of lectin microarrays in cancer diagnosis. Proteomics. 2016;16:1257-65 pubmed publisher

More Information

Publications101 found, 100 shown here

  1. Westerlund Karlsson A, Suonpää K, Ankelo M, Ilonen J, Knip M, Hinkkanen A. Detection of autoantibodies to protein tyrosine phosphatase-like protein IA-2 with a novel time-resolved fluorimetric assay. Clin Chem. 2003;49:916-23 pubmed
    ..This assay allows substantial reduction in performance time compared with the conventional RBA. ..
  2. Koskinen M, Vartiainen N. Removal of ballistocardiogram artifact from EEG data acquired in the MRI scanner: selection of ICA components. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:5220-3 pubmed publisher
    ..The suggested methods may provide objective means to validate residual artifact or the possible loss of physiological signal due to artifact removal and to help selecting the proper artifact-related components. ..
  3. Jauhiainen M, Mönkkönen H, Räikkönen J, Mönkkönen J, Auriola S. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877:2967-75 pubmed publisher
    ..4nmol/mg of protein and amount of ApppI and ApppD was 1.1nmol/mg protein. Relative portions of the isomers were approximately 1:4 IPP:DMAPP and 3:7 ApppI:ApppD. Untreated control samples did not contain IPP, DMAPP, ApppI or ApppD. ..
  4. Korhonen P, Husa T, Konttila T, Tierala I, Mäkijärvi M, Väänänen H, et al. Fragmented QRS in prediction of cardiac deaths and heart failure hospitalizations after myocardial infarction. Ann Noninvasive Electrocardiol. 2010;15:130-7 pubmed publisher
    ..Increased QRS fragmentation in post-MI patients predicts cardiac deaths and HF progression. A computer-based fragmentation analysis is a stronger predictor than QRSd. ..
  5. Huhtala T, Laakkonen P, Sallinen H, Yla Herttuala S, Närvänen A. In vivo SPECT/CT imaging of human orthotopic ovarian carcinoma xenografts with 111In-labeled monoclonal antibodies. Nucl Med Biol. 2010;37:957-64 pubmed publisher
    ..Systemically administered they had slow pharmacokinetics which is typical for antibodies. Accumulation of mF4-31C1 antibody in the lymph nodes suggests the remote activation of VEGFR-3 by the primary tumor. ..
  6. Jaakkola J, Hakala P, Isolauri E, Poussa T, Laitinen K. Eating behavior influences diet, weight, and central obesity in women after pregnancy. Nutrition. 2013;29:1209-13 pubmed publisher
    ..We propose that measuring eating behavior by the simple questionnaire could be a helpful tool in dietary counseling that aids in identifying women who are likely at risk for unhealthy dietary patterns and for developing overweight. ..
  7. Kauhanen S, Seppanen M, Ovaska J, Minn H, Bergman J, Korsoff P, et al. The clinical value of [18F]fluoro-dihydroxyphenylalanine positron emission tomography in primary diagnosis, staging, and restaging of neuroendocrine tumors. Endocr Relat Cancer. 2009;16:255-65 pubmed publisher
    ..Both in primary diagnosis and in patients with formerly known NET and increasing tumor markers, [(18)F]DOPA PET-CT is a sensitive first-line imaging method. ..
  8. Vaisanen V, Eriksson S, Ivaska K, Lilja H, Nurmi M, Pettersson K. Development of sensitive immunoassays for free and total human glandular kallikrein 2. Clin Chem. 2004;50:1607-17 pubmed
    ..The new assay is sufficiently sensitive to be used to study the diagnostic accuracies of free and total hK2 for prostate cancer. ..
  9. Lahti L, Elo L, Aittokallio T, Kaski S. Probabilistic analysis of probe reliability in differential gene expression studies with short oligonucleotide arrays. IEEE/ACM Trans Comput Biol Bioinform. 2011;8:217-25 pubmed publisher
    ..This provides insights into the various sources of probe-level noise and gives tools to guide probe design. ..
  10. Virtanen A, Gomari M, Kranse R, Stenman U. Estimation of prostate cancer probability by logistic regression: free and total prostate-specific antigen, digital rectal examination, and heredity are significant variables. Clin Chem. 1999;45:987-94 pubmed
    ..The probability calculated by logistic regression provides better diagnostic accuracy for prostate cancer than the presently used multistep algorithms for estimation of the need to perform biopsy. ..
  11. Kauhanen L, Nykopp T, Lehtonen J, Jylänki P, Heikkonen J, Rantanen P, et al. EEG and MEG brain-computer interface for tetraplegic patients. IEEE Trans Neural Syst Rehabil Eng. 2006;14:190-3 pubmed
    ..Classification accuracies obtained with dynamic classifier were better, at 75%, 89%, and 91% in different subjects, when features were in the 0.5-3.0-Hz frequency band. Classification accuracies of EEG and MEG did not differ. ..
  12. Amundsen L, Siren H. Partial filling micellar electrokinetic chromatography analysis of androgens and testosterone derivatives using two sequential pseudostationary phases. J Chromatogr A. 2006;1131:267-74 pubmed
    ..Limits of detection were between 73 microg/L (testosterone) and 160 microg/L (fluoxymesterone). As a demonstration of the method, androstenedione, testosterone and epitestosterone were determined in a spiked urine sample. ..
  13. Toivanen A, Arokoski J, Manninen P, Heliovaara M, Haara M, Tyrväinen E, et al. Agreement between clinical and radiological methods of diagnosing knee osteoarthritis. Scand J Rheumatol. 2007;36:58-63 pubmed
    ..The agreement between the clinical diagnosis performed in a large population study and radiological grading scales was only moderate. By contrast, the agreement between different radiological scales was substantial. ..
  14. Hartonen M, Mattila I, Ruskeepää A, Oresic M, Hyötyläinen T. Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. J Chromatogr A. 2013;1293:142-9 pubmed publisher
    ..The GC×GC-TOFMS allowed detection and identification of several metabolites that have not been previously detected in CSF. ..
  15. Tarvainen T, Kolehmainen V, Vauhkonen M, Vanne A, Gibson A, Schweiger M, et al. Computational calibration method for optical tomography. Appl Opt. 2005;44:1879-88 pubmed
    ..The results show that the coupling coefficients of the sources and detectors can be estimated with good accuracy. Furthermore, the results show that the method can significantly improve the quality of reconstructed images. ..
  16. Mustonen A, Koivikko M, Haapamaki V, Kiuru M, Lamminen A, Koskinen S. Multidetector computed tomography in acute knee injuries: assessment of cruciate ligaments with magnetic resonance imaging correlation. Acta Radiol. 2007;48:104-11 pubmed
    ..MDCT can detect an intact ACL and PCL with good specificity, accuracy, and negative predictive value. The assessment of torn ligaments is unreliable. ..
  17. Strandén I, Garrick D. Technical note: Derivation of equivalent computing algorithms for genomic predictions and reliabilities of animal merit. J Dairy Sci. 2009;92:2971-5 pubmed publisher
    ..There were 3 solving strategies compared: 1 method that formed and stored the coefficient matrix in memory and 2 methods that iterate on data. Finally, formulas for reliabilities of genomic predictions of merit were developed. ..
  18. Linko A, Parikka K, Wahala K, Adlercreutz H. Gas chromatographic-mass spectrometric method for the determination of alkylresorcinols in human plasma. Anal Biochem. 2002;308:307-13 pubmed
    ..The alkylresorcinols were in the unconjugated form. The total amounts of alkylresorcinols in two plasma samples analyzed here were 333 and 381nmol/L. ..
  19. Hirvonen J, Aalto S, Lumme V, NAgren K, Kajander J, Vilkman H, et al. Measurement of striatal and thalamic dopamine D2 receptor binding with 11C-raclopride. Nucl Med Commun. 2003;24:1207-14 pubmed
    ..However, the signal-to-noise ratio for quantification may become too low especially in receptor occupancy-type studies, leading to an artefactual underestimation of measured D2 receptor occupancy. ..
  20. Haiminen N, Mannila H, Terzi E. Determining significance of pairwise co-occurrences of events in bursty sequences. BMC Bioinformatics. 2008;9:336 pubmed publisher
    ..More sophisticated models give better results in our experiments. We also demonstrate the effect of the window size, i.e., maximum co-occurrence distance, on the significance results. ..
  21. Lyytikäinen M, Rantalainen A, Mikkelson P, Hamalainen H, Paasivirta J, Kukkonen J. Similarities in bioaccumulation patterns of polychlorinated dibenzo-p-dioxins and furans and polychlorinated diphenyl ethers in laboratory-exposed oligochaetes and semipermeable membrane devices and in field-collected chironomids. Environ Toxicol Chem. 2003;22:2405-15 pubmed
    ..The SPMDs were found to give good predictions of the PCDD/F concentrations of sediments and oligochaetes. For PCDEs, the estimates were slightly poorer, but still useful for preliminary concentration assessments. ..
  22. Koskela A, Samaletdin A, Aubertin Leheudre M, Adlercreutz H. Quantification of alkylresorcinol metabolites in plasma by high-performance liquid chromatography with coulometric electrode array detection. J Agric Food Chem. 2008;56:7678-81 pubmed publisher
    ..Additional investigation is needed to clarify whether the two plasma AR metabolites are useful as biomarkers of whole-grain intake and helpful in the exploration of the association between whole-grain cereal intake and human diseases. ..
  23. Uutela P, Ketola R, Piepponen P, Kostiainen R. Comparison of different amino acid derivatives and analysis of rat brain microdialysates by liquid chromatography tandem mass spectrometry. Anal Chim Acta. 2009;633:223-31 pubmed publisher
    ..996-0.999, range=100-8500nmolL(-1)). Propyl chloroformate was the best suited of the reagents tested for the analysis of amino acids with LC-MS/MS and was used for the analysis of amino acids in rat brain microdialysis samples. ..
  24. Metso T, Rytila P, Peterson C, Haahtela T. Granulocyte markers in induced sputum in patients with respiratory disorders and healthy persons obtained by two sputum-processing methods. Respir Med. 2001;95:48-55 pubmed
    ..The study method, measuring total inflammatory markers, gave comparable results to the reference method, measuring released markers. In the study method the sputum processing was simplified, which may improve its applicability. ..
  25. Lioumis P, Kicić D, Savolainen P, Mäkelä J, Kahkonen S. Reproducibility of TMS-Evoked EEG responses. Hum Brain Mapp. 2009;30:1387-96 pubmed publisher
    ..The results suggest that nTMS-EEG is a reliable tool for studies investigating cortical excitability changes in the test-retest designs. ..
  26. Elo L, Hiissa J, Tuimala J, Kallio A, Korpelainen E, Aittokallio T. Optimized detection of differential expression in global profiling experiments: case studies in clinical transcriptomic and quantitative proteomic datasets. Brief Bioinform. 2009;10:547-55 pubmed publisher
    ..To promote its widespread usage, we have made freely available efficient implementations of ROTS, which are easily accessible either as a stand-alone R-package or as integrated in the open-source data analysis software Chipster. ..
  27. Hourdakis C, Büermann L, Ciraj Bjelac O, Csete I, Delis H, Gomola I, et al. Comparison of pencil-type ionization chamber calibration results and methods between dosimetry laboratories. Phys Med. 2016;32:42-51 pubmed publisher
    ..34% to 2.32% depending on the quantity, beam quality and calibration method applied. Detailed analysis of the assigned uncertainties have been presented and discussed. ..
  28. Saari J, Kivela T, Summanen P, Nummelin K, Saari K. Digital imaging in differential diagnosis of small choroidal melanoma. Graefes Arch Clin Exp Ophthalmol. 2006;244:1581-90 pubmed
    ..The subtraction method may reveal early growth of the melanotic choroidal tumors. ..
  29. Vehtari A, Mäkinen V, Soininen P, Ingman P, Mäkelä S, Savolainen M, et al. A novel Bayesian approach to quantify clinical variables and to determine their spectroscopic counterparts in 1H NMR metabonomic data. BMC Bioinformatics. 2007;8 Suppl 2:S8 pubmed
    ..Nevertheless, the combination of high-quality quantification and the biochemical rationale of the resulting models is expected to be useful in the field of metabonomics. ..
  30. Kortelainen J, Mendez M, Bianchi A, Matteucci M, Cerutti S. Sleep staging based on signals acquired through bed sensor. IEEE Trans Inf Technol Biomed. 2010;14:776-85 pubmed publisher
    ..44+/-0.19 with three HBI features and one movement parameter. These results suggest that the combination of HBI and movement features could be a suitable alternative for sleep staging with the advantage of low cost and simplicity. ..
  31. Manninen O, Koskenkorva P, Lehtimäki K, Hyppönen J, Kononen M, Laitinen T, et al. White matter degeneration with Unverricht-Lundborg progressive myoclonus epilepsy: a translational diffusion-tensor imaging study in patients and cystatin B-deficient mice. Radiology. 2013;269:232-9 pubmed publisher
    ..These data suggest that motor disturbances and other symptoms in patients with EPM1 involve not only the cortical system but also the thalamocortical system and cerebellum. ..
  32. Niinivehmas S, Manivannan E, Rauhamäki S, Huuskonen J, Pentikäinen O. Identification of estrogen receptor α ligands with virtual screening techniques. J Mol Graph Model. 2016;64:30-39 pubmed publisher
    ..Furthermore, our small in-house compound collection of easy-to-synthesize molecules was virtually screened against ERα, yielding to five hit candidates, which were found to be active in vitro having pIC50 values from 5.5 to 6.5. ..
  33. Rajaratnam R, Gylling H, Miettinen T. Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. J Am Coll Cardiol. 2000;35:1185-91 pubmed
    ..Thus, enhanced absorption and reduced synthesis of cholesterol may be related to coronary atherosclerosis. ..
  34. Ankelo M, Westerlund Karlsson A, Ilonen J, Knip M, Savola K, Kankaanpää P, et al. Time-resolved fluorometric assay for detection of autoantibodies to glutamic acid decarboxylase (GAD65). Clin Chem. 2003;49:908-15 pubmed
    ..It has a broad linear analytical range, is easy to perform and automate, and has sensitivity and specificity comparable to those for the conventional radioisotope assay. ..
  35. Keto Timonen R, Autio T, Korkeala H. An improved amplified fragment length polymorphism (AFLP) protocol for discrimination of Listeria isolates. Syst Appl Microbiol. 2003;26:236-44 pubmed
    ..We conclude that the AFLP protocol is a highly discriminatory, reproducible and valuable tool in characterisation of Listeria strains and may also be suitable for Listeria species identification. ..
  36. Nissila I, Hebden J, Jennions D, Heino J, Schweiger M, Kotilahti K, et al. Comparison between a time-domain and a frequency-domain system for optical tomography. J Biomed Opt. 2006;11:064015 pubmed
    ..The image quality of the reconstructions from the data measured with the two systems were compared with several quantitative criteria. In general a higher contrast was observed in the images calculated from the HUT data. ..
  37. Mutshinda C, Sillanpää M. Extended Bayesian LASSO for multiple quantitative trait loci mapping and unobserved phenotype prediction. Genetics. 2010;186:1067-75 pubmed publisher
    ..Consequently, the EBL seems to point to a new direction for QTL mapping, phenotype prediction, and GBV estimation. ..
  38. Sallinen R, Tornberg J, Putkiranta M, Horelli Kuitunen N, Airaksinen M, Wessman M. Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K(+)-Cl(-) cotransporter (KCC2) defines a new region of conserved homology. Cytogenet Cell Genet. 2001;94:67-70 pubmed
    ..We hence suggest the first region of conserved homology between human Chr 20 and mouse Chr 5. ..
  39. Forsstrom T, Tuominen J, Kärkkäinen J. Determination of potentially hallucinogenic N-dimethylated indoleamines in human urine by HPLC/ESI-MS-MS. Scand J Clin Lab Invest. 2001;61:547-56 pubmed
    ..Method, procedure, considerations, statistical evaluations and urine sample spectra are presented...
  40. Svedström Oristo A, Pietila T, Pietilä I, Helenius H, Peutzfeldt P, Varrela J. Selection of criteria for assessment of occlusal acceptability. Acta Odontol Scand. 2002;60:160-6 pubmed
    ..Further studies are needed to analyse the reproducibility of assessment of the characteristics included...
  41. Räty R, Rönkkö E, Kleemola M. Sample type is crucial to the diagnosis of Mycoplasma pneumoniae pneumonia by PCR. J Med Microbiol. 2005;54:287-91 pubmed
    ..5 %) of the swabs. Serology with increasing or high titres supported the positive findings in all instances. Sputum, when available, is clearly the best sample type for young adults with pneumonia...
  42. Mattila M, Kielinen M, Linna S, Jussila K, Ebeling H, Bloigu R, et al. Autism spectrum disorders according to DSM-IV-TR and comparison with DSM-5 draft criteria: an epidemiological study. J Am Acad Child Adolesc Psychiatry. 2011;50:583-592.e11 pubmed publisher
    ..DSM-IV-TR helps with the definition of ASDs only up to a point. We suggest modifications to five details of DSM-5 draft criteria posted by the APA in February 2010. Completing revision of DSM criteria for ASDs is a challenging task. ..
  43. Kinnunen H, Tanskanen M, Kyrolainen H, Westerterp K. Wrist-worn accelerometers in assessment of energy expenditure during intensive training. Physiol Meas. 2012;33:1841-54 pubmed publisher
    ..97 ± 0.02). In the 45 min field march test, the AR measured similar f_hand as on the treadmill at the same speed. In conclusion, the wrist-worn AR can be regarded as a reliable and valid method for assessing EE during intensive training...
  44. Hariri A, Velaga S, Girach A, Ip M, Le P, Lam B, et al. Measurement and Reproducibility of Preserved Ellipsoid Zone Area and Preserved Retinal Pigment Epithelium Area in Eyes With Choroideremia. Am J Ophthalmol. 2017;179:110-117 pubmed publisher
    ..These variables would be potential anatomic outcome measures for CHM clinical trials and could be studied and tracked longitudinally in choroideremia. ..
  45. Raininko R, Manninen H, Battié M, Gibbons L, Gill K, Fisher L. Observer variability in the assessment of disc degeneration on magnetic resonance images of the lumbar and thoracic spine. Spine (Phila Pa 1976). 1995;20:1029-35 pubmed
    ..However, assessments were substantially more variable between readers, which limits comparisons of evaluations between different readers. ..
  46. Hendolin P, Markkanen A, Ylikoski J, Wahlfors J. Use of multiplex PCR for simultaneous detection of four bacterial species in middle ear effusions. J Clin Microbiol. 1997;35:2854-8 pubmed
    ..Thus, the multiplex PCR method improves the detection rate significantly compared to that of the conventional culture method. ..
  47. Piepponen T, Skujins A. Rapid and sensitive step gradient assays of glutamate, glycine, taurine and gamma-aminobutyric acid by high-performance liquid chromatography-fluorescence detection with o-phthalaldehyde-mercaptoethanol derivatization with an emphasis on microdialysi. J Chromatogr B Biomed Sci Appl. 2001;757:277-83 pubmed
    ..Total analysis time was less than 12 min, including the wash-out step. The methods described are relatively simple, sensitive, inexpensive, and fast enough to keep up with the microdialysis sampling...
  48. Svedström U, Vuorela H, Kostiainen R, Huovinen K, Laakso I, Hiltunen R. High-performance liquid chromatographic determination of oligomeric procyanidins from dimers up to the hexamer in hawthorn. J Chromatogr A. 2002;968:53-60 pubmed
    ..The correlation coefficients of calibration curves were between 0.997 and 1.000. The limits of quantitation for different procyanidin standards were 0.05-0.12 mg/ml, when 10 microl of each standard solution was injected into the HPLC...
  49. Suvinen T, Reade P, Kononen M, Kemppainen P. Vertical jaw separation and masseter muscle electromyographic activity: a comparative study between asymptomatic controls & patients with temporomandibular pain & dysfunction. J Oral Rehabil. 2003;30:765-72 pubmed
  50. Salminen J. Effects of sample drying and storage, and choice of extraction solvent and analysis method on the yield of birch leaf hydrolyzable tannins. J Chem Ecol. 2003;29:1289-305 pubmed
  51. von Lode P, Rosenberg J, Pettersson K, Takalo H. A europium chelate for quantitative point-of-care immunoassays using direct surface measurement. Anal Chem. 2003;75:3193-201 pubmed
    ..The novel nonadentate label facilitates short turnaround times and simple instrumentation due to the absence of all signal development steps, at the same time retaining an excellent immunoassay performance...
  52. Kopylov P, Fränti P. Compression of map images by multilayer context tree modeling. IEEE Trans Image Process. 2005;14:1-11 pubmed
    ..The proposed method gives results 50% better than JBIG and 25% better than a single-layer context tree modeling. ..
  53. Kalueff A, Tuohimaa P. The grooming analysis algorithm discriminates between different levels of anxiety in rats: potential utility for neurobehavioural stress research. J Neurosci Methods. 2005;143:169-77 pubmed
    ..Our results suggest that this method can be a useful tool in neurobehavioural stress research including modelling stress-evoked states, psychopharmacological or behavioural neurogenetics research in rats. ..
  54. Kiema T, Lad Y, Jiang P, Oxley C, Baldassarre M, Wegener K, et al. The molecular basis of filamin binding to integrins and competition with talin. Mol Cell. 2006;21:337-47 pubmed
    ..Phosphothreonine-mimicking mutations inhibit filamin, but not talin, binding, indicating that kinases may modulate this competition and provide additional means to control integrin functions. ..
  55. Salmi E, Aalto S, Hirvonen J, Långsjö J, Maksimow A, Oikonen V, et al. Measurement of GABAA receptor binding in vivo with [11C]flumazenil: a test-retest study in healthy subjects. Neuroimage. 2008;41:260-9 pubmed publisher
    ..The voxel-based analysis methods are proper alternative as the reliability is preserved and analysis automated. ..
  56. Moilanen P, Talmant M, Kilappa V, Nicholson P, Cheng S, Timonen J, et al. Modeling the impact of soft tissue on axial transmission measurements of ultrasonic guided waves in human radius. J Acoust Soc Am. 2008;124:2364-73 pubmed publisher
    ..A theoretical model that accounts for the impact of an overlying soft tissue could thus be used in clinical applications. ..
  57. Leinonen M, Nieminen P, Kotaniemi Talonen L, Malila N, Tarkkanen J, Laurila P, et al. Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting. J Natl Cancer Inst. 2009;101:1612-23 pubmed publisher
    ..Among women aged 35 years or older, primary HPV DNA screening with cytology triage is also more specific than conventional screening and decreases colposcopy referrals and follow-up tests. ..
  58. Ahvenjarvi L, Koivukangas V, Jartti A, Ohtonen P, Saarnio J, Syrjala H, et al. Diagnostic accuracy of computed tomography imaging of surgically treated acute acalculous cholecystitis in critically ill patients. J Trauma. 2011;70:183-8 pubmed publisher
    ..Acute acalculous cholecystitis (AAC) is a potentially fatal condition mainly affecting critically ill patients. Current experience from computed tomography (CT) findings in AAC is contradictory...
  59. Paakkunainen M, Kohonen J, Reinikainen S. Measurement uncertainty of lactase-containing tablets analyzed with FTIR. J Pharm Biomed Anal. 2014;88:513-8 pubmed publisher
    ..0% expanded uncertainty level. Uncertainty arising from the FTIR instrument was <1.0%. The uncertainty estimates are computed directly from FTIR spectra without any concentration information of the analyte. ..
  60. Tenovuo J. Salivary parameters of relevance for assessing caries activity in individuals and populations. Community Dent Oral Epidemiol. 1997;25:82-6 pubmed
    ..Of the parameters involved in de- and remineralization process, only salivary fluoride content has some association with caries susceptibility but its diagnostic or predictive value is questionable. ..
  61. Panelius J, Lahdenne P, Heikkilä T, Peltomaa M, Oksi J, Seppälä I. Recombinant OspC from Borrelia burgdorferi sensu stricto, B. afzelii and B. garinii in the serodiagnosis of Lyme borreliosis. J Med Microbiol. 2002;51:731-9 pubmed
    ..Because of the heterogeneity of OspC, a polyvalent antigen with several OspC variants from at least B. afzelii and B. garinii is needed to improve the sensitivity of OspC ELISA in the serodiagnosis of LB in Europe. ..
  62. Huhtinen P, Soukka T, Lövgren T, Harma H. Immunoassay of total prostate-specific antigen using europium(III) nanoparticle labels and streptavidin-biotin technology. J Immunol Methods. 2004;294:111-22 pubmed
    ..The general characteristics of this combination should permit the development of various immunoassay applications featuring high sensitivity, rapidity, and low consumption of reagents...
  63. Valli K, Revonsuo A, Pälkäs O, Ismail K, Ali K, Punamaki R. The threat simulation theory of the evolutionary function of dreaming: Evidence from dreams of traumatized children. Conscious Cogn. 2005;14:188-218 pubmed
    ..The dream threats of traumatized children were also more severe in nature than the threats of less traumatized or non-traumatized children. ..
  64. Kauppinen T, Koskela A, Diemling M, Keski Rahkonen A, Sihvola E, Ahonen A. Comparison of manual and automated quantification methods of 123I-ADAM. Nuklearmedizin. 2005;44:205-12 pubmed
    ..An automated method for analysing 123I-ADAM binding to the brain SERT gives repeatable results for fitting the studies to the template and for calculating SBRs, and could therefore replace manual methods. ..
  65. Lähdesmäki R, Alvesalo L. Root growth in the permanent teeth of 45,X/46,XX females. Eur J Orthod. 2006;28:339-44 pubmed
    ..It is suggested that the reduction in crown and root growth in 45,X/4,XX females is due to a deficiency in the amount of dental growth-promoting genes on the sex chromosomes...
  66. Oksanen A, Ylinen J, Pöyhönen T, Anttila P, Laimi K, Hiekkanen H, et al. Repeatability of electromyography and force measurements of the neck muscles in adolescents with and without headache. J Electromyogr Kinesiol. 2007;17:493-503 pubmed
    ..The aim of this study was to determine the intra-tester repeatability of EMG and isometric force measurements of the neck muscles in adolescents with headache and headache-free controls...
  67. Pól J, Kauppila T, Haapala M, Saarela V, Franssila S, Ketola R, et al. Microchip sonic spray ionization. Anal Chem. 2007;79:3519-23 pubmed
    ..The microchip SSI provided dynamic linearity following a pattern similar to that used with electrospray, good quantitative repeatability (RSD=16%), and long-term signal stability. ..
  68. Talvinen K, Tuikkala J, Nevalainen O, Rantanen A, Hirsimäki P, Sundstrom J, et al. Proliferation marker securin identifies favourable outcome in invasive ductal breast cancer. Br J Cancer. 2008;99:335-40 pubmed publisher
    ..We suggest that securin immunostaining is a promising and clinically applicable proliferation marker. The finding urges further prognostic studies with a large sample of patients. ..
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    ..It is concluded that generalized bacterial infections do not lead to elevated serum levels of GIIE, GIIF, GIII, GV and GX PLA(2)s above the detection limits of the current TR-FIAs. ..
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    ..2. The HPLC methods developed can be used for the qualitative and quantitative analysis of different phenolic compounds in hawthorn plant material and their extracts. ..
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    ..This study suggests that TMA technique could be useful to study histological correlations and prognostic significance of cyclin A on breast cancer on a large scale. ..
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    ..The results showed improved accuracy over common approaches and illustrated the method's suitability for simulation purposes. ..
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    ..Further studies are needed to assess whether the disk diffusion test could be improved or whether all susceptibilities of campylobacters should be tested using an MIC-based method...
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    ..The absolute values of band densities had a more remarkable variation (than 4%) in both agarose and PAGE gels. Our recommendation is that quantitation of PCR products be done with band density ratio estimates, and in thin PAGE gels. ..
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    ..Because most of these blocks are currently routinely sampled by the majority of laboratories, assessment of the A-beta phase in AD is feasible even in large scale retrospective studies. ..
  88. Johanna Haukkala -, Iina Laitinen -, Pauliina Luoto -, Peter Iveson -, Ian Wilson -, Hege Karlsen -, et al. 68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice. Eur J Nucl Med Mol Imaging. 2009;36:2058-67 pubmed publisher
    ..However, this data only shows the feasibility of the approach, while the clinical significance still remains to be proven. Further studies are warranted to assess the uptake of this tracer into human atherosclerotic plaques. ..
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    ..They also imply that it is necessary to create new data models for personal health information and new architectures which support situation depending trust and privacy management. ..
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    ..However, in clinical settings there are special challenges related to recording and privacy issues, a wide variety of clinical practices and contexts of technology usage, as well as the hectic nature of clinical work. ..