Experts and Doctors on reactive oxygen species in Finland


Locale: Finland
Topic: reactive oxygen species

Top Publications

  1. Dorman H, Lantto T, Raasmaja A, Hiltunen R. Antioxidant, pro-oxidant and cytotoxic properties of parsley. Food Funct. 2011;2:328-37 pubmed publisher
    ..In conclusion, the toxicity might be explained by the pro-oxidative activity of components within the extract against proteins and/or DNA but it is not related to caspase 3-dependent apoptosis within cells. ..
  2. Pesonen M, Häkkinen M, Rilla K, Juvonen R, Kuitunen T, Pasanen M, et al. Chloropicrin-induced toxic responses in human lung epithelial cells. Toxicol Lett. 2014;226:236-44 pubmed publisher
    ..The protective effect of NAC as a potential antidote in chloropicrin intoxication will require further investigation. ..
  3. Mills E, Kelly B, Logan A, Costa A, Varma M, Bryant C, et al. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell. 2016;167:457-470.e13 pubmed publisher
    ..The metabolic alterations that occur upon activation of macrophages therefore repurpose mitochondria from ATP synthesis to ROS production in order to promote a pro-inflammatory state. ..
  4. Repo J, Pesonen M, Mannelli C, Vahakangas K, Loikkanen J. Exposure to ethanol and nicotine induces stress responses in human placental BeWo cells. Toxicol Lett. 2014;224:264-71 pubmed publisher
    ..This study shows that ethanol and nicotine, which harm the development of fetus may induce both oxidative and ER stress responses in human placental trophoblastic cells, implicating these mechanisms in their fetotoxic effects. ..
  5. Skommer J, Wlodkowic D, Pelkonen J. Cellular foundation of curcumin-induced apoptosis in follicular lymphoma cell lines. Exp Hematol. 2006;34:463-74 pubmed
    ..We have demonstrated for the first time that curcumin is an efficient inducer of apoptosis in FL cell lines, meriting its further evaluation in vivo. ..
  6. Bimbo L, Mäkilä E, Laaksonen T, Lehto V, Salonen J, Hirvonen J, et al. Drug permeation across intestinal epithelial cells using porous silicon nanoparticles. Biomaterials. 2011;32:2625-33 pubmed publisher
    ..There was no evidence of the porous nanoparticles crossing the Caco-2 cell monolayers, yet increased permeation of the loaded poorly soluble drug, griseofulvin, was shown. ..
  7. Wrzaczek M, Brosché M, Kangasjärvi J. ROS signaling loops - production, perception, regulation. Curr Opin Plant Biol. 2013;16:575-82 pubmed publisher
    ..Direct redox modification of transcription factors and other proteins are critical for the perception of intracellular reactive oxygen species; however, sensing of their extracellular counterparts awaits elucidation. ..
  8. Kangasjärvi S, Neukermans J, Li S, Aro E, Noctor G. Photosynthesis, photorespiration, and light signalling in defence responses. J Exp Bot. 2012;63:1619-36 pubmed publisher
    ..Particular emphasis is placed on the potential roles of the chloroplast, photorespiration, and photoreceptor-associated pathways in regulating the outcome of interactions between plants and pathogenic organisms. ..
  9. Kinnula V, Raivio K, Linnainmaa K, Ekman A, Klockars M. Neutrophil and asbestos fiber-induced cytotoxicity in cultured human mesothelial and bronchial epithelial cells. Free Radic Biol Med. 1995;18:391-9 pubmed
    ..In conclusion, this study suggests the importance of inflammatory cell-derived free radicals in the development of amosite-induced mesothelial cell injury. ..

More Information


  1. Heiskanen K, Savolainen K. Erucic acid and erucic acid anilide-induced oxidative burst in human polymorphonuclear leukocytes. Free Radic Res. 1997;27:477-85 pubmed
    ..The present results show that aniline moiety modifies the effects of erucic acid on the activation of PMNL, and suggest that both erucic acid and erucic acid anilide may activate PMNL through a protein kinase C-dependent mechanism. ..
  2. Martinsuo P, Pursiheimo S, Aro E, Rintamäki E. Dithiol oxidant and disulfide reductant dynamically regulate the phosphorylation of light-harvesting complex II proteins in thylakoid membranes. Plant Physiol. 2003;133:37-46 pubmed
  3. Kallio T, Kallio J, Jaakkola M, Mäki M, Kilpeläinen P, Virtanen V. Urolithins display both antioxidant and pro-oxidant activities depending on assay system and conditions. J Agric Food Chem. 2013;61:10720-9 pubmed publisher
    ..These results illustrate how strongly measured redox properties depend on the employed assay system and conditions and emphasize the importance of studying pro-oxidant and antioxidant activities in parallel. ..
  4. Blokhina O, Fagerstedt K. Reactive oxygen species and nitric oxide in plant mitochondria: origin and redundant regulatory systems. Physiol Plant. 2010;138:447-62 pubmed publisher
    ..Mitochondrial ROS and NO production is tightly controlled by multiple redundant systems providing the regulatory mechanism for redox homeostasis and specific ROS/NO signaling. ..
  5. Pylväs M, Puistola U, Kauppila S, Soini Y, Karihtala P. Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis. Eur J Cancer. 2010;46:1661-7 pubmed publisher
    ..This difference could also offer a potential tool for differential diagnosis between benign and borderline epithelial ovarian tumours. ..
  6. Ketola K, Hilvo M, Hyötyläinen T, Vuoristo A, Ruskeepää A, Oresic M, et al. Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. Br J Cancer. 2012;106:99-106 pubmed publisher
  7. Moilanen J, Karonen M, Tähtinen P, Jacquet R, Quideau S, Salminen J. Biological activity of ellagitannins: Effects as anti-oxidants, pro-oxidants and metal chelators. Phytochemistry. 2016;125:65-72 pubmed publisher
  8. Virtanen T, Pihlanto A, Akkanen S, Korhonen H. Development of antioxidant activity in milk whey during fermentation with lactic acid bacteria. J Appl Microbiol. 2007;102:106-15 pubmed
    ..To the best of our knowledge, this seems to be the first report, which screens possible antioxidant activity among most common dairy LAB strains. Use of such strains improve nutritional value of fermented dairy products. ..
  9. Pellinen R, Korhonen M, Tauriainen A, Palva E, Kangasjärvi J. Hydrogen peroxide activates cell death and defense gene expression in birch. Plant Physiol. 2002;130:549-60 pubmed
    ..Thus, it appears that at least two separate defense pathways can be activated in birch leaves by stress factors, even though the early H(2)O(2) accumulation response is common among them all. ..
  10. Vääräniemi J, Halleen J, Kaarlonen K, Ylipahkala H, Alatalo S, Andersson G, et al. Intracellular machinery for matrix degradation in bone-resorbing osteoclasts. J Bone Miner Res. 2004;19:1432-40 pubmed
  11. Goldsteins G, Keksa Goldsteine V, Ahtoniemi T, Jaronen M, Arens E, Akerman K, et al. Deleterious role of superoxide dismutase in the mitochondrial intermembrane space. J Biol Chem. 2008;283:8446-52 pubmed publisher
    ..The mitochondrial dysfunction and cell damage paradoxically induced by SOD1-mediated ROS production may be implicated in chronic degenerative diseases. ..
  12. Hänninen S, Ronkainen J, Leskinen H, Tavi P. Mitochondrial uncoupling downregulates calsequestrin expression and reduces SR Ca2+ stores in cardiomyocytes. Cardiovasc Res. 2010;88:75-82 pubmed publisher
    ..As impaired mitochondrial function has been implicated in several cardiac pathologies as well as in normal ageing, the mechanisms described here might be involved in a wide spectrum of cardiac conditions. ..
  13. Sanz A, Fernandez Ayala D, Stefanatos R, Jacobs H. Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. Aging (Albany NY). 2010;2:200-23 pubmed
    ..In summary, these results do not systematically support the predictions of the MFRTA. Accordingly, MFRTA should be revised to accommodate these findings. ..
  14. Vahisalu T, Puzõrjova I, Brosché M, Valk E, Lepiku M, Moldau H, et al. Ozone-triggered rapid stomatal response involves the production of reactive oxygen species, and is controlled by SLAC1 and OST1. Plant J. 2010;62:442-53 pubmed publisher
    ..The absence of the RTD in the dominant-negative mutants abi1-1 and abi2-1 also suggested a regulatory role for the protein phosphatases ABI1 and ABI2 in the ROS-induced activation of the S-type anion channel. ..
  15. Scialò F, Sriram A, Fernández Ayala D, Gubina N, Lõhmus M, Nelson G, et al. Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 2016;23:725-34 pubmed publisher
    ..These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging. ..
  16. Idänheimo N, Gauthier A, Salojärvi J, Siligato R, Brosché M, Kollist H, et al. The Arabidopsis thaliana cysteine-rich receptor-like kinases CRK6 and CRK7 protect against apoplastic oxidative stress. Biochem Biophys Res Commun. 2014;445:457-62 pubmed publisher
    ..CRK6 and CRK7 are active protein kinases with differential preference for divalent cations. Our results suggest that CRK7 is involved in mediating the responses to extracellular but not chloroplastic ROS production. ..
  17. Pätsikkä E, Kairavuo M, Sersen F, Aro E, Tyystjärvi E. Excess copper predisposes photosystem II to photoinhibition in vivo by outcompeting iron and causing decrease in leaf chlorophyll. Plant Physiol. 2002;129:1359-67 pubmed
    ..Plant species adapted to high-light habitats apparently benefit from thick leaves because the rate of photoinhibition is directly proportional to light intensity, but photosynthesis becomes saturated by moderate light. ..
  18. Lepistö A, Pakula E, Toivola J, Krieger Liszkay A, Vignols F, Rintamäki E. Deletion of chloroplast NADPH-dependent thioredoxin reductase results in inability to regulate starch synthesis and causes stunted growth under short-day photoperiods. J Exp Bot. 2013;64:3843-54 pubmed publisher
    ..It is proposed that knockout of NTRC challenges redox regulation of starch synthesis, resulting in stunted growth of the mutant lines acclimated to the SD photoperiod. ..
  19. Ruddock L. Low-molecular-weight oxidants involved in disulfide bond formation. Antioxid Redox Signal. 2012;16:1129-38 pubmed publisher
    ..Hence knowledge of the mechanisms for their formation is critical for understanding a myriad of cellular processes and associated disease states...
  20. Lintala M, Lehtimäki N, Benz J, Jungfer A, Soll J, Aro E, et al. Depletion of leaf-type ferredoxin-NADP(+) oxidoreductase results in the permanent induction of photoprotective mechanisms in Arabidopsis chloroplasts. Plant J. 2012;70:809-17 pubmed publisher
    ..Intriguingly, the fnr1?fnr2 plants were still capable of sustaining the biogenesis of a few malformed chloroplasts...
  21. Zanotto E, Lehtonen V, Jacobs H. Modulation of Mrps12/Sarsm promoter activity in response to mitochondrial stress. Biochim Biophys Acta. 2008;1783:2352-62 pubmed publisher
    ..Promoter stimulation was correlated with mitochondrial ROS production, which may be a crucial component in its signalling. ..
  22. Trotta A, Wrzaczek M, Scharte J, Tikkanen M, Konert G, Rahikainen M, et al. Regulatory subunit B'gamma of protein phosphatase 2A prevents unnecessary defense reactions under low light in Arabidopsis. Plant Physiol. 2011;156:1464-80 pubmed publisher
    ..We suggest that the specific B'? subunit of PP2A is functionally connected to CPR5 and operates in the basal repression of defense responses under low irradiance. ..
  23. Lehtimäki N, Shunmugam S, Jokela J, Wahlsten M, Carmel D, Keranen M, et al. Nodularin uptake and induction of oxidative stress in spinach (Spinachia oleracea). J Plant Physiol. 2011;168:594-600 pubmed publisher
  24. Sanz A, Soikkeli M, Portero Otin M, Wilson A, Kemppainen E, McIlroy G, et al. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Proc Natl Acad Sci U S A. 2010;107:9105-10 pubmed publisher
    ..Our results support a central role of mitochondrial oxidative phosphorylation complex I in influencing longevity via oxidative stress, independently of pathways connected to nutrition and growth signaling. ..
  25. Luukkonen J, Hakulinen P, Mäki Paakkanen J, Juutilainen J, Naarala J. Enhancement of chemically induced reactive oxygen species production and DNA damage in human SH-SY5Y neuroblastoma cells by 872 MHz radiofrequency radiation. Mutat Res. 2009;662:54-8 pubmed publisher
    ..However, there is no known mechanism that would explain such effects from CW RF radiation but not from GSM modulated RF radiation at identical SAR. ..
  26. Overmyer K, Brosché M, Pellinen R, Kuittinen T, Tuominen H, Ahlfors R, et al. Ozone-induced programmed cell death in the Arabidopsis radical-induced cell death1 mutant. Plant Physiol. 2005;137:1092-104 pubmed
    ..Furthermore, mitogen-activated protein kinases showed differential activation patterns in rcd1 and Columbia. Taken together, these results directly demonstrate the induction of PCD by O(3). ..
  27. Wrzaczek M, Brosché M, Kollist H, Kangasjärvi J. Arabidopsis GRI is involved in the regulation of cell death induced by extracellular ROS. Proc Natl Acad Sci U S A. 2009;106:5412-7 pubmed publisher
    ..Analysis of the extracellular GRI protein yields information on how plants can initiate ROS-induced cell death during stress response and development. ..
  28. Suorsa M, Järvi S, Grieco M, Nurmi M, Pietrzykowska M, Rantala M, et al. PROTON GRADIENT REGULATION5 is essential for proper acclimation of Arabidopsis photosystem I to naturally and artificially fluctuating light conditions. Plant Cell. 2012;24:2934-48 pubmed publisher
    ..This shows not only that regulation of PSI under natural growth conditions is crucial but also the importance of PGR5 in PSI protection. ..