Experts and Doctors on rats in United Kingdom


Locale: United Kingdom
Topic: rats

Top Publications

  1. Turner K, Sharpe R, Gaughan J, Millar M, Foster P, Saunders P. Expression cloning of a rat testicular transcript abundant in germ cells, which contains two leucine zipper motifs. Biol Reprod. 1997;57:1223-32 pubmed
  2. Selyanko A, Delmas P, Hadley J, Tatulian L, Wood I, Mistry M, et al. Dominant-negative subunits reveal potassium channel families that contribute to M-like potassium currents. J Neurosci. 2002;22:RC212 pubmed
    ..This experimental approach should therefore be useful in delineating the contributions of members of these two gene families to K+ currents in other cells. ..
  3. Sanna B, Kramer D, Genazzani A. The expression of the PDZ protein MALS-1/velis is regulated by calcium and calcineurin in cerebellar granule cells. J Biol Chem. 2002;277:49585-90 pubmed
    ..These data suggest that Ca(2+) entry by means of calcineurin is capable of controlling the structure of the post-synaptic density by controlling the expression of key components at the transcriptional level. ..
  4. Lapiz M, Fulford A, Muchimapura S, Mason R, Parker T, Marsden C. Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission. Neurosci Behav Physiol. 2003;33:13-29 pubmed
    ..A greater understanding of the processes that underlie these changes should improve our knowledge of how environmental events may alter brain development and function, and play a role in the development of neuropsychiatric disorders. ..
  5. de Koning H, Anderson L, Stewart M, Burchmore R, Wallace L, Barrett M. The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes. Antimicrob Agents Chemother. 2004;48:1515-9 pubmed
    ..We conclude that TbAT1 mediates [(3)H]diminazene transport almost exclusively and that this explains the observed diminazene resistance phenotypes of TbAT1-null mutants and field isolates. ..
  6. Lorber B, Berry M, Hendriks W, den Hertog J, Pulido R, Logan A. Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTPalpha, STEP, and LAR. Mol Cell Neurosci. 2004;27:404-16 pubmed
    ..One explanation of these findings is that RPTPalpha and LAR may modulate RGC survival, and that RPTPalpha, STEP, and LAR may modulate axon growth. ..
  7. Kola B, Hubina E, Tucci S, Kirkham T, Garcia E, Mitchell S, et al. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol Chem. 2005;280:25196-201 pubmed
    ..Our data demonstrate that AMPK not only links the orexigenic effects of endocannabinoids and ghrelin in the hypothalamus but also their effects on the metabolism of peripheral tissues. ..
  8. Ainge J, Tamosiunaite M, Woergoetter F, Dudchenko P. Hippocampal CA1 place cells encode intended destination on a maze with multiple choice points. J Neurosci. 2007;27:9769-79 pubmed
  9. Hendrich J, Van Minh A, Heblich F, Nieto Rostro M, Watschinger K, Striessnig J, et al. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A. 2008;105:3628-33 pubmed publisher

More Information

Publications439 found, 100 shown here

  1. Blomeley C, Kehoe L, Bracci E. Substance P mediates excitatory interactions between striatal projection neurons. J Neurosci. 2009;29:4953-63 pubmed publisher
    ..The current view that MSNs form inhibitory networks characterized by competitive dynamics will have to be updated to incorporate the fact that groups of MSNs interact in an excitatory manner. ..
  2. Clayton E, Anggono V, Smillie K, Chau N, Robinson P, Cousin M. The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles. J Neurosci. 2009;29:7706-17 pubmed publisher
    ..The results reveal that the phospho-dependent dynamin-syndapin interaction recruits ADBE to massively increase SV endocytosis under conditions of elevated neuronal activity. ..
  3. Arthur Farraj P, Wanek K, Hantke J, Davis C, Jayakar A, Parkinson D, et al. Mouse schwann cells need both NRG1 and cyclic AMP to myelinate. Glia. 2011;59:720-33 pubmed publisher
    ..They demonstrate unambiguously the promyelin effects of NRG1 in purified cells, and they show that the cAMP pathway determines whether NRG1 drives proliferation or induces myelin differentiation...
  4. Ito R, Hayen A. Opposing roles of nucleus accumbens core and shell dopamine in the modulation of limbic information processing. J Neurosci. 2011;31:6001-7 pubmed publisher
    ..It is further proposed that NAc core DA may be critical in regulating limbic information flow through the NAc shell. ..
  5. Weatherall K, Seutin V, Liégeois J, Marrion N. Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels. Proc Natl Acad Sci U S A. 2011;108:18494-9 pubmed publisher
    ..This arrangement provides a unique binding site for each combination of SK subunits within a coassembled channel that may be targeted to produce blockers specific for heteromeric SK channels. ..
  6. Li X, Lin Y, Kinsey Jones J, O Byrne K. High-fat diet increases LH pulse frequency and kisspeptin-neurokinin B expression in puberty-advanced female rats. Endocrinology. 2012;153:4422-31 pubmed publisher
  7. Mobasheri A, Shakibaei M. Is tendinitis an inflammatory disease initiated and driven by pro-inflammatory cytokines such as interleukin 1??. Histol Histopathol. 2013;28:955-64 pubmed publisher
    ..Reaching a consensus will be important for the development and refinement of biomimetic models of tendon inflammation and the formulation of new therapeutic strategies for the treatment of tendon injuries. ..
  8. Denk F, Huang W, Sidders B, Bithell A, Crow M, Grist J, et al. HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain. Pain. 2013;154:1668-79 pubmed publisher
    ..Taken together, these data support a role for histone acetylation in the emergence of neuropathic pain. ..
  9. Bale M, Davies K, Freeman O, Ince R, Petersen R. Low-dimensional sensory feature representation by trigeminal primary afferents. J Neurosci. 2013;33:12003-12 pubmed publisher
    ..Our results suggest that the first stage of the whisker system can be well approximated as a bank of linear filters, forming an overcomplete representation of a low-dimensional feature space. ..
  10. Ferguson S, Glean A, Holdsworth C, Wright J, Fees A, Colburn T, et al. Skeletal Muscle Vascular Control During Exercise: Impact of Nitrite Infusion During Nitric Oxide Synthase Inhibition in Healthy Rats. J Cardiovasc Pharmacol Ther. 2016;21:201-8 pubmed publisher
    ..38 L-NAME vs L-NAME + NO2 (-)). Individuals with diseases that impair NOS activity, and thus vascular function, may benefit from a NO2 (-)-based therapy in which NO bioavailability is elevated in an NOS-independent manner. ..
  11. Harrison B, Venkat G, Lamb J, Hutson T, Drury C, Rau K, et al. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J Neurosci. 2016;36:4259-75 pubmed publisher
    ..CD2AP is the first signaling molecule associated with adult sensory axonal collateral sprouting, and this association may offer new insights for NGF/TrkA-related Alzheimer's disease mechanisms. ..
  12. Chen T, Rotival M, Chiu L, Bagnati M, Ko J, Srivastava P, et al. Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function. Genetics. 2017;206:1139-1151 pubmed publisher
    ..These results suggest that genetically determined Cp levels can alter susceptibility to Crgn through macrophage function and propose a new role for Cp in early macrophage activation. ..
  13. Hirst K, Simmons D, Feng J, Aplin H, Dixon M, MacDougall M. Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II. Genomics. 1997;42:38-45 pubmed
  14. Harrold J, Widdowson P, Clapham J, Williams G. Individual severity of dietary obesity in unselected Wistar rats: relationship with hyperphagia. Am J Physiol Endocrinol Metab. 2000;279:E340-7 pubmed
    ..5 +/- 0.1 vs. 37.6 +/- 0.1 degrees C; P > 0.5). We conclude that a higher energy intake is the critical factor determining susceptibility to dietary obesity in unselected Wistar rats...
  15. Armesilla A, Williams J, Buch M, Pickard A, Emerson M, Cartwright E, et al. Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1). J Biol Chem. 2004;279:31318-28 pubmed
    ..Furthermore, the functional association with RASSF1 indicates a role for PMCA4b in the modulation of Ras-mediated signaling. ..
  16. Ashby M, De La Rue S, Ralph G, Uney J, Collingridge G, Henley J. Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs. J Neurosci. 2004;24:5172-6 pubmed
    ..We show that synaptic and extrasynaptic AMPARs respond very differently to NMDA receptor activation; there is a rapid internalization of extrasynaptic AMPARs that precedes the delayed removal of synaptic AMPARs. ..
  17. Baldrick P. Carcinogenicity evaluation: comparison of tumor data from dual control groups in the Sprague-Dawley rat. Toxicol Pathol. 2005;33:283-91 pubmed
    ..The paper also presents an update on survival, on the range and extent of background spontaneous neoplasms, and comments on genetic drift in this commonly used rat strain. ..
  18. Williams S. Encoding and decoding of dendritic excitation during active states in pyramidal neurons. J Neurosci. 2005;25:5894-902 pubmed
    ..During active states, therefore, distal excitatory synaptic inputs decisively control the excitatory synaptic output of layer 5 neocortical pyramidal neurons and so powerfully influence network activity in the neocortex. ..
  19. Fang X, Djouhri L, McMullan S, Berry C, Waxman S, Okuse K, et al. Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1.9 expression. J Neurosci. 2006;26:7281-92 pubmed
    ..We conclude that strongly IB4+ DRG neurons are exclusively C-nociceptor type and that high Nav1.9 expression may contribute to their distinct membrane properties. ..
  20. Huxter J, Zinyuk L, Roloff E, Clarke V, Dolman N, More J, et al. Inhibition of kainate receptors reduces the frequency of hippocampal theta oscillations. J Neurosci. 2007;27:2212-23 pubmed
    ..In addition, the effects on cellular responses provide both insight into the mechanisms of theta pacing, and useful information for models of temporal coding. ..
  21. Causeret F, Jacobs T, Terao M, Heath O, Hoshino M, Nikolic M. Neurabin-I is phosphorylated by Cdk5: implications for neuronal morphogenesis and cortical migration. Mol Biol Cell. 2007;18:4327-42 pubmed
    ..Together our findings provide new insight into the signaling pathways responsible for controlled changes of the F-actin cytoskeleton that are required for normal development of the forebrain. ..
  22. Mercer A, Eastlake K, Trigg H, Thomson A. Local circuitry involving parvalbumin-positive basket cells in the CA2 region of the hippocampus. Hippocampus. 2012;22:43-56 pubmed publisher
    ..Connections with low probabilities of release had higher PPR. Quantal amplitude (q) for the facilitating connections was larger than q at depressing inputs onto fast spiking basket cells. ..
  23. Nelson A, Thur K, Horsley R, Spicer C, Marsden C, Cassaday H. Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition. Pharmacol Biochem Behav. 2011;98:1-7 pubmed publisher
    ..These results underscore the dissociable roles of core and shell subregions of the NAc in mediating the expression of LI and indicate that reduced DA function within the medial shell leads to enhanced LI. ..
  24. Cheshire D, Aberg A, Andersson G, Andrews G, Beaton H, Birkinshaw T, et al. The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS). Bioorg Med Chem Lett. 2011;21:2468-71 pubmed publisher
    ..By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8. ..
  25. Mar A, Walker A, Theobald D, Eagle D, Robbins T. Dissociable effects of lesions to orbitofrontal cortex subregions on impulsive choice in the rat. J Neurosci. 2011;31:6398-404 pubmed publisher
    ..The findings are consistent with recent human functional imaging studies and suggest that functions of mOFC and lOFC subregions may be evolutionarily conserved and contribute differentially to decision-making processes. ..
  26. Ciani L, Boyle K, Dickins E, Sahores M, Anane D, Lopes D, et al. Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²?/Calmodulin-dependent protein kinase II. Proc Natl Acad Sci U S A. 2011;108:10732-7 pubmed publisher
    ..Therefore, aberrant Wnt7a signaling may contribute to neurological disorders in which excitatory signaling is disrupted. ..
  27. Tymanskyj S, Scales T, Gordon Weeks P. MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons. Mol Cell Neurosci. 2012;49:110-9 pubmed publisher
    ..These findings show that MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons by binding to dynamic microtubules. ..
  28. Klyuch B, Dale N, Wall M. Deletion of ecto-5'-nucleotidase (CD73) reveals direct action potential-dependent adenosine release. J Neurosci. 2012;32:3842-7 pubmed publisher
    ..Our findings are a major step in understanding the mechanisms of adenosine release and are likely to have implications for all aspects of physiology where adenosine plays a key modulatory role. ..
  29. Flores Munoz M, Godinho B, Almalik A, Nicklin S. Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin type 2 receptor. PLoS ONE. 2012;7:e45564 pubmed publisher
    ..This supports applications for this approach for sustained peptide delivery to study molecular effects and potential gene therapeutic actions. ..
  30. Macgregor D, Leng G. Phasic firing in vasopressin cells: understanding its functional significance through computational models. PLoS Comput Biol. 2012;8:e1002740 pubmed publisher
    ..These findings show large differences in information coding between the populations, and apparent functional advantages of asynchronous phasic firing. ..
  31. Okun M, Yger P, Marguet S, Gerard Mercier F, Benucci A, Katzner S, et al. Population rate dynamics and multineuron firing patterns in sensory cortex. J Neurosci. 2012;32:17108-19 pubmed publisher
  32. Dick G, Tan C, Alves J, Ehlert E, Miller G, Hsieh Wilson L, et al. Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains. J Biol Chem. 2013;288:27384-95 pubmed publisher
    ..In conclusion, Sema3A binding to CS-E in the PNNs may be a mechanism whereby PNNs restrict growth and plasticity and may represent a possible point of intervention to facilitate neuronal plasticity. ..
  33. Neher J, Emmrich J, Fricker M, Mander P, Thery C, Brown G. Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc Natl Acad Sci U S A. 2013;110:E4098-107 pubmed publisher
    ..Therefore, inhibition of specific phagocytic pathways may present therapeutic targets for preventing delayed neuronal loss after transient cerebral ischemia. ..
  34. Meisel C, Klaus A, Vyazovskiy V, Plenz D. The Interplay between Long- and Short-Range Temporal Correlations Shapes Cortex Dynamics across Vigilance States. J Neurosci. 2017;37:10114-10124 pubmed publisher
    ..Our findings thus suggest two distinct states in terms of timescale dynamics. During extended wake, the rapid switching to sleep-like states with short timescales can lead to an overall decline in cortical timescales. ..
  35. Jeffery G. PNS features of rodent optic nerve axons. J Comp Neurol. 1996;366:370-8 pubmed
    ..They develop caudally, mirroring glial maturation. It is probable that the glia are maturing astrocytes that provide a scaffold for this feature of optic axon trajectory. ..
  36. Pearson S, Cawthorne M, Clapham J, Dunmore S, Holmes S, Moore G, et al. The thiazolidinedione insulin sensitiser, BRL 49653, increases the expression of PPAR-gamma and aP2 in adipose tissue of high-fat-fed rats. Biochem Biophys Res Commun. 1996;229:752-7 pubmed
    ..PPAR-gamma and aP2 mRNA expression were significantly increased in the high-fat-fed rats treated with BRL 49653 (p < 0.01 and p < 0.001 respectively), but not in carbohydrate-fed rats. ..
  37. Hirst R, Sikand K, Rutman A, Mitchell T, Andrew P, O Callaghan C. Relative roles of pneumolysin and hydrogen peroxide from Streptococcus pneumoniae in inhibition of ependymal ciliary beat frequency. Infect Immun. 2000;68:1557-62 pubmed
    ..There is also a slight additive effect of pneumolysin and H(2)O(2) on ependymal toxicity; however, the precise mechanism of action and the role of these toxins in pathogenesis remain unclear. ..
  38. Smith B, Kennedy W, Harnden P, Selby P, Trejdosiewicz L, Southgate J. Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium. Cancer Res. 2001;61:1678-85 pubmed
  39. Klausberger T, Roberts J, Somogyi P. Cell type- and input-specific differences in the number and subtypes of synaptic GABA(A) receptors in the hippocampus. J Neurosci. 2002;22:2513-21 pubmed
    ..The high number of GABA(A) receptors in synapses on basket cells might contribute to the precisely timed phasing of basket cell activity. ..
  40. Bobanovic L, Royle S, Murrell Lagnado R. P2X receptor trafficking in neurons is subunit specific. J Neurosci. 2002;22:4814-24 pubmed
    ..P2X receptors acted presynaptically to enhance the release of glutamate, suggesting that the regulated cycling of P2X4-containing receptors might provide a mechanism for modulation of synaptic transmission. ..
  41. Melyan Z, Lancaster B, Wheal H. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci. 2004;24:4530-4 pubmed
    ..These data describe a new physiological function for glutamate release: activation of metabotropic kainate receptors, which control directly the excitability of pyramidal cells and probably contribute to prolonged excitability changes. ..
  42. Sim J, Young M, Sung H, North R, Surprenant A. Reanalysis of P2X7 receptor expression in rodent brain. J Neurosci. 2004;24:6307-14 pubmed
    ..Either the P2X7 protein in the hippocampus is below the limits of detection by the currently available methods or it is not present. ..
  43. Campbell S, Perry V, Pitossi F, Butchart A, Chertoff M, Waters S, et al. Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver. Am J Pathol. 2005;166:1487-97 pubmed
    ..Thus, combined production of CC and CXC hepatic chemokines appears to amplify the central nervous system response to injury. ..
  44. Carulli D, Rhodes K, Brown D, Bonnert T, Pollack S, Oliver K, et al. Composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components. J Comp Neurol. 2006;494:559-77 pubmed
    ..We therefore propose that HASs, which can retain HA on the cell surface, may act as a link between PNNs and neurons. Thus, HAS and link proteins might be key molecules for PNN formation and stability. ..
  45. Ward E, Stambach N, Drickamer K, Taylor M. Polymorphisms in human langerin affect stability and sugar binding activity. J Biol Chem. 2006;281:15450-6 pubmed
    ..These findings suggest that certain langerin haplotypes may differ in their binding to pathogens and thus might be associated with susceptibility to infection. ..
  46. Dallas M, Boycott H, Atkinson L, Miller A, Boyle J, Pearson H, et al. Hypoxia suppresses glutamate transport in astrocytes. J Neurosci. 2007;27:3946-55 pubmed
    ..Suppression of glutamate uptake via this mechanism may be an important contributory factor in hypoxic/ischemic triggered glutamate excitotoxicity. ..
  47. Sands C, Coen M, Maher A, Ebbels T, Holmes E, Lindon J, et al. Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery. Anal Chem. 2009;81:6458-66 pubmed publisher
    ..Additionally, this tool could prove useful for applications outside of metabolic analysis, for example, in process chemistry for following chemical reactions and equilibria and detecting impurities. ..
  48. Harries L, Brown J, Gloyn A. Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes. PLoS ONE. 2009;4:e7855 pubmed publisher
    ..We conclude that alterations to expression of HNF isoforms may underlie some of the phenotypic variation caused by mutations in these genes. ..
  49. Delivopoulos E, Murray A, Curtis J. Effects of parylene-C photooxidation on serum-assisted glial and neuronal patterning. J Biomed Mater Res A. 2010;94:47-58 pubmed publisher
    ..c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010. ..
  50. Fox B, Devonshire A, Schutte M, Foy C, Minguez J, Przyborski S, et al. Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers. Toxicol In Vitro. 2010;24:1962-70 pubmed publisher
    ..We conclude that accurate quantification of gene expression requires the use of a validated normalisation strategy for each species and experimental system employed. ..
  51. Taylor S, Calder C, Albon J, Erichsen J, Boulton M, Morgan J. Involvement of the CD200 receptor complex in microglia activation in experimental glaucoma. Exp Eye Res. 2011;92:338-43 pubmed publisher
  52. Konopacki F, Jaafari N, Rocca D, Wilkinson K, Chamberlain S, Rubin P, et al. Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis. Proc Natl Acad Sci U S A. 2011;108:19772-7 pubmed publisher
    ..Thus, direct phosphorylation by PKC and GluK2 SUMOylation are intimately linked in regulating the surface expression and function of GluK2-containing KARs. ..
  53. Cheung G, Cousin M. Adaptor protein complexes 1 and 3 are essential for generation of synaptic vesicles from activity-dependent bulk endosomes. J Neurosci. 2012;32:6014-23 pubmed publisher
    ..Thus, adaptor protein complexes 1 and 3 play an essential dual role in generation of synaptic vesicles during activity-dependent bulk endocytosis. ..
  54. Ashek A, Menzies R, Mullins L, Bellamy C, Harmar A, Kenyon C, et al. Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat. PLoS ONE. 2012;7:e36311 pubmed publisher
    ..Furthermore, renal vascular injury in this setting reflects both barotrauma and pressure-independent pathways associated with direct detrimental effects of angiotensin II and aldosterone. ..
  55. Pournaras D, Glicksman C, Vincent R, Kuganolipava S, Alaghband Zadeh J, Mahon D, et al. The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control. Endocrinology. 2012;153:3613-9 pubmed publisher
    ..and satiety gut hormone concentrations. Elucidating the mechanism of action of gastric bypass surgery may lead to novel treatments for type 2 diabetes...
  56. Drakakis G, Wafford K, Brewerton S, Bodkin M, Evans D, Bender A. Polypharmacological in Silico Bioactivity Profiling and Experimental Validation Uncovers Sedative-Hypnotic Effects of Approved and Experimental Drugs in Rat. ACS Chem Biol. 2017;12:1593-1602 pubmed publisher
    ..The method described extends previous single-target, single-mode-of-action models and is applicable across disease areas. ..
  57. Sharott A, Vinciati F, Nakamura K, Magill P. A Population of Indirect Pathway Striatal Projection Neurons Is Selectively Entrained to Parkinsonian Beta Oscillations. J Neurosci. 2017;37:9977-9998 pubmed publisher
    ..Our results provide an important link between two complementary theories that explain the presentation of disease symptoms on the basis of changes in firing rate or firing synchronization/rhythmicity. ..
  58. Lara Pezzi E, Felkin L, Birks E, Sarathchandra P, Panse K, George R, et al. Expression of follistatin-related genes is altered in heart failure. Endocrinology. 2008;149:5822-7 pubmed publisher
  59. Davies B, Pickard B, Steel M, Morris R, Lathe R. Serine proteases in rodent hippocampus. J Biol Chem. 1998;273:23004-11 pubmed
    ..In contrast, and despite robust expression of t-PA, the usual t-PA substrate plasminogen was not expressed at detectable levels. ..
  60. Haynes L, Evans G, Morgan A, Burgoyne R. A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells. J Biol Chem. 2001;276:9726-32 pubmed
    ..We propose that Noc2 may be a negative effector for Rab3A in regulated exocytosis of dense-core granules from endocrine cells. ..
  61. Mould A, Askari J, Barton S, Kline A, McEwan P, Craig S, et al. Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain. J Biol Chem. 2002;277:19800-5 pubmed
    ..The mechanism of beta subunit A-domain activation appears to be distinct from that of the A-domains found in some integrin alpha subunits. ..
  62. Utton M, Connell J, Asuni A, van Slegtenhorst M, Hutton M, de Silva R, et al. The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons. J Neurosci. 2002;22:6394-400 pubmed
  63. Burdyga G, Lal S, Varro A, Dimaline R, Thompson D, Dockray G. Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin. J Neurosci. 2004;24:2708-15 pubmed
    ..Because CCK is a satiety factor that acts via the vagus nerve and CB1 agonists stimulate food intake, the data suggest a new mechanism modulating the effect on food intake of satiety signals from the gastrointestinal tract. ..
  64. Joy S, Siow R, Rowlands D, Becker M, Wyatt A, Aaronson P, et al. The isoflavone Equol mediates rapid vascular relaxation: Ca2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells. J Biol Chem. 2006;281:27335-45 pubmed
    ..Identification of the nongenomic mechanisms by which equol mediates vascular relaxation provides a basis for evaluating potential benefits of equol in the treatment of postmenopausal women and patients at risk of cardiovascular disease. ..
  65. Leith J, Wilson A, Donaldson L, Lumb B. Cyclooxygenase-1-derived prostaglandins in the periaqueductal gray differentially control C- versus A-fiber-evoked spinal nociception. J Neurosci. 2007;27:11296-305 pubmed
    ..Thus, effects of centrally acting prostaglandins are pivotal, we suggest, to both the understanding of nociceptive processing and the development of new analgesic drugs. ..
  66. Fukushima S, Coppen S, Lee J, Yamahara K, Felkin L, Terracciano C, et al. Choice of cell-delivery route for skeletal myoblast transplantation for treating post-infarction chronic heart failure in rat. PLoS ONE. 2008;3:e3071 pubmed publisher
    ..Late-phase arrhythmogenicity remains a concern, regardless of the delivery route. ..
  67. Economidou D, Pelloux Y, Robbins T, Dalley J, Everitt B. High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence. Biol Psychiatry. 2009;65:851-6 pubmed publisher
    ..Impulsivity pre-dating drug abuse increases the susceptibility to relapse after abstinence. Medications targeting impulsivity might have utility as treatment interventions for relapse prevention and the promotion of abstinence. ..
  68. Auharek S, de Franca L, McKinnell C, Jobling M, Scott H, Sharpe R. Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat. Endocrinology. 2010;151:2868-75 pubmed publisher
  69. Andreae L, Fredj N, Burrone J. Independent vesicle pools underlie different modes of release during neuronal development. J Neurosci. 2012;32:1867-74 pubmed publisher
    ..These two modes of vesicle cycling derive from distinct pools throughout development and the initiation of activity-dependent release was independent of postsynaptic contacts, suggesting it is an autonomous presynaptic event. ..
  70. Jenkins S, Weinberg D, Al Shakli A, Fernandes A, Yiu H, Telling N, et al. 'Stealth' nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics. J Control Release. 2016;224:136-145 pubmed publisher
    ..We demonstrate changes in protein coronas around these particles within biological media, and discuss how surface chemistry presentation may affect this process and subsequent cellular interactions. ..
  71. Wilkie G, Hutson P, Sullivan J, Wonnacott S. Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes. Neurochem Res. 1996;21:1141-8 pubmed
    ..These results are discussed in terms of possible nicotinic receptor subtypes that might be present on hippocampal nerve terminals. ..
  72. Nan X, Campoy F, Bird A. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell. 1997;88:471-81 pubmed
    ..These properties, together with the abundance of MeCP2 and the high frequency of its 2 bp binding site, suggest a role as a global transcriptional repressor in vertebrate genomes. ..
  73. White A, Yoshimura T, Smith A, Westwick J, Watson M. Airway inflammation induced by recombinant guinea pig tumor necrosis factor-alpha. Am J Physiol. 1997;273:L524-30 pubmed
    ..Maximum BAL eosinophilia was observed at 24 h, but eosinophil numbers remained significantly above vehicle-treated animals for 72 h. Hence, gpTNF-alpha elicits a pronounced and protracted eosinophil accumulation in the guinea pig lung...
  74. Clifford G, Londos C, Kraemer F, Vernon R, Yeaman S. Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes. J Biol Chem. 2000;275:5011-5 pubmed
    ..A loss of the ability to translocate HSL to the lipid droplet probably contributes to the diminished lipolytic response to catecholamines with age. ..
  75. Lindahl G, Chambers R, Papakrivopoulou J, Dawson S, Jacobsen M, Bishop J, et al. Activation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter. J Biol Chem. 2002;277:6153-61 pubmed
    ..Furthermore, these findings suggest a novel and potentially important TGF-beta response element in the rat COL1A1 gene. ..
  76. Hopper R, Garthwaite J. Tonic and phasic nitric oxide signals in hippocampal long-term potentiation. J Neurosci. 2006;26:11513-21 pubmed
    ..It is concluded that tonic and phasic NO signals are both required for hippocampal LTP and the two are generated, respectively, by eNOS and nNOS, the former in blood vessels and the latter in neurons. ..
  77. Sadek A, Magill P, Bolam J. A single-cell analysis of intrinsic connectivity in the rat globus pallidus. J Neurosci. 2007;27:6352-62 pubmed
  78. Salah Uddin H, Thomas D, Davies C, Hagan J, Wood M, Watson J, et al. Pharmacological assessment of m1 muscarinic acetylcholine receptor-gq/11 protein coupling in membranes prepared from postmortem human brain tissue. J Pharmacol Exp Ther. 2008;325:869-74 pubmed publisher
  79. Dawson N, Ferrington L, Olverman H, Kelly P. Novel analysis for improved validity in semi-quantitative 2-deoxyglucose autoradiographic imaging. J Neurosci Methods. 2008;175:25-35 pubmed publisher
    ..g. normoglycaemia) are met this analytical technique both increases the validity of LCMRglu estimation by the semi-quantitative method and also allows for its broader experimental application. ..
  80. Pires S, Hughes S, Turton M, Melyan Z, Peirson S, Zheng L, et al. Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina. J Neurosci. 2009;29:12332-42 pubmed publisher
  81. Thompson S, Fernig D, Jesudason E, Losty P, van de Westerlo E, van Kuppevelt T, et al. Heparan sulfate phage display antibodies identify distinct epitopes with complex binding characteristics: insights into protein binding specificities. J Biol Chem. 2009;284:35621-31 pubmed publisher
  82. Magoulas C, Jasim A, Lopez de Heredia L. Prediction of novel isoforms of the mouse Mpv17l protein. Genome. 2009;52:968-74 pubmed publisher
  83. Sunters A, Armstrong V, Zaman G, Kypta R, Kawano Y, Lanyon L, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 r. J Biol Chem. 2010;285:8743-58 pubmed publisher
    ..This cascade requires prostanoid/nitric oxide production and is independent of Wnt/LRP5. ..
  84. Redfern W, Storey S, Tse K, Hussain Q, Maung K, Valentin J, et al. Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice. J Pharmacol Toxicol Methods. 2011;63:102-14 pubmed publisher
    ..Both albino and pigmented mice and rats are suitable for assessment of retinotoxicity using this method, but albino rats are the most sensitive to sodium iodate. ..
  85. Korfali N, Wilkie G, Swanson S, Srsen V, Batrakou D, Fairley E, et al. The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture. Mol Cell Proteomics. 2010;9:2571-85 pubmed publisher
  86. Puddifoot C, Martel M, Soriano F, Camacho A, Vidal Puig A, Wyllie D, et al. PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity. J Neurosci. 2012;32:6995-7000 pubmed publisher
    ..The link between mHtt, PGC-1α, and NMDAR activity was also confirmed in rat striatal neurons. Thus, targeting levels of PGC-1α expression may help reduce aberrant NMDAR(EX) activity in disorders where PGC-1α is underexpressed. ..
  87. Ermolyuk Y, Alder F, Surges R, Pavlov I, Timofeeva Y, Kullmann D, et al. Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type Ca2+ channels. Nat Neurosci. 2013;16:1754-1763 pubmed publisher
    ..Uncorrelated stochastic VGCC opening is therefore a major trigger for spontaneous glutamate release, with differential roles for distinct channel subtypes. ..
  88. Du X, Dart A, Riemersma R. Lack of modulation by dietary unsaturated fats on sympathetic neurotransmission in rat hearts. Am J Physiol. 1993;265:H886-92 pubmed
    ..Thus a modification of sympathetic neurotransmission was not achieved by feeding PUFA-enriched diets for 10 wk. ..
  89. Chamberlain L, Burgoyne R. Identification of a novel cysteine string protein variant and expression of cysteine string proteins in non-neuronal cells. J Biol Chem. 1996;271:7320-3 pubmed
    ..We suggest that Csps may have a more general role in membrane traffic in non-neuronal as well as neuronal cells. ..
  90. Lockyer P, Vanlingen S, Reynolds J, McNulty T, Irvine R, Parys J, et al. Tissue-specific expression and endogenous subcellular distribution of the inositol 1,3,4,5-tetrakisphosphate-binding proteins GAP1(IP4BP) and GAP1(m). Biochem Biophys Res Commun. 1999;255:421-6 pubmed
    ..As GAP1(m) is primarily localised to the cytosol of unstimulated cells it may be spatially regulated in order to interact with Ras at the plasma membrane. ..
  91. Graves J, Greenwood I, Large W. Tonic regulation of vascular tone by nitric oxide and chloride ions in rat isolated small coronary arteries. Am J Physiol Heart Circ Physiol. 2000;279:H2604-11 pubmed
    ..This study suggests that, in rat coronary arteries, NO tonically suppresses a contractile mechanism that involves a Cl(-) conductance...
  92. Patel S, Lochhead P, Rena G, Fumagalli S, Pende M, Kozma S, et al. Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity. J Biol Chem. 2002;277:9889-95 pubmed
    ..Therefore, although the insulin-responsive sequence of the G6Pase gene promoter is related to that of the IGFBP-1 promoter, the signaling pathways that mediate suppression of these genes are distinct. ..