Genomes and Genes
Experts and Doctors on rats in France
Publications638 found, 100 shown here
- Pain F, Dhenain M, Gurden H, Routier A, Lefebvre F, Mastrippolito R, et al. A method based on Monte Carlo simulations and voxelized anatomical atlases to evaluate and correct uncertainties on radiotracer accumulation quantitation in beta microprobe studies in the rat brain. Phys Med Biol. 2008;53:5385-404 pubmed publisher
- Bregeon J, Loirand G, Pacaud P, Rolli Derkinderen M. Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2009;297:C1062-70 pubmed publisher..Our work then defines p190A as a new mediator of RhoA activation by ANG II in VSMC. ..
- Tekpli X, Rissel M, Huc L, Catheline D, Sergent O, Rioux V, et al. Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. Toxicol Appl Pharmacol. 2010;243:68-76 pubmed publisher..In F258 cells, the B[alpha]P-induced membrane remodeling was identified as an early apoptotic event leading to an intracellular alkalinization. ..
- Tanguy S, Toufektsian M, Grauzam S, de Leiris J, Ghezzi C, Boucher F, et al. Cardiac dysfunction in rats with dietary-induced insulin resistance associated with pharmacologically-induced dyslipidemia. Curr Pharm Des. 2013;19:6906-11 pubmed..This experimental model of combined IR and DL closely mimics the main clinical manifestations of DCM and might therefore constitute a useful tool for the evaluation of pharmacological treatments. ..
- Vindrieux D, Devonec M, Benahmed M, Grataroli R. Identification of tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) and its receptors in adult rat ventral prostate. Mol Cell Endocrinol. 2002;198:115-21 pubmed..TRAIL and its receptors were identified in the rat ventral prostate in terms of protein and mRNA. TRAIL and its receptors were immunolocalized in prostatic epithelial cells. ..
- Mérot Y, Ferrière F, Debroas E, Flouriot G, Duval D, Saligaut C. Estrogen receptor alpha mediates neuronal differentiation and neuroprotection in PC12 cells: critical role of the A/B domain of the receptor. J Mol Endocrinol. 2005;35:257-67 pubmed..Altogether, these results underline the importance of the A/B domain of ER alpha in both the differentiating and the neuroprotective effects of estrogens. ..
- Pena A, Murat B, Trueba M, Ventura M, Bertrand G, Cheng L, et al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007;148:4136-46 pubmed..In conclusion, d[Leu(4), Lys(8)]VP is the first selective agonist available for the rat V(1b) VP receptor. It will allow a better understanding of V(1b) receptor-mediated effects in rodents. ..
- Zhang L, Tran N, Chen H, Kahn C, Marchal S, Groubatch F, et al. Time-related changes in expression of collagen types I and III and of tenascin-C in rat bone mesenchymal stem cells under co-culture with ligament fibroblasts or uniaxial stretching. Cell Tissue Res. 2008;332:101-9 pubmed publisher..Radioimmunoassay results confirmed the effects of these stimulations, showing increases in the level of these proteins. Thus, BMSC might be useful as a cell source for the tissue engineering of ligament. ..
- Pritchett Corning K, Cosentino J, Clifford C. Contemporary prevalence of infectious agents in laboratory mice and rats. Lab Anim. 2009;43:165-73 pubmed publisher..pneumotropica, and pinworms. A risk-based allocation of health-monitoring resources should concentrate frequency and/or sample size on these high-risk agents, and monitor less frequently for the remaining, lower-risk, infectious agents. ..
- Guyonnet B, Dacheux F, Dacheux J, Gatti J. The epididymal transcriptome and proteome provide some insights into new epididymal regulations. J Androl. 2011;32:651-64 pubmed publisher..This review will focus on possible new control mechanisms that these studies have suggested for this tissue...
- De Mazancourt P, Lacasa D, Giot J, Giudicelli Y. Role of adenosine 3',5'-monophosphate and the Ri-receptor Gi-coupled adenylate cyclase inhibitory pathway in the mechanism whereby adrenalectomy increases the adenosine antilipolytic effect in rat fat cells. Endocrinology. 1989;124:1131-9 pubmed
- Allaoua H, Chicheportiche R. Anaesthetic properties of phencyclidine (PCP) and analogues may be related to their interaction with Na+ channels. Eur J Pharmacol. 1989;163:327-35 pubmed..It was concluded that the interaction of these drugs with the Na+ channel may reflect their anaesthetic properties while the interaction with the PCP receptors may be mainly related to their anticonvulsant and ataxic properties...
- Cardoso C, Timsit S, Villard L, Khrestchatisky M, Fontes M, Colleaux L. Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein. Hum Mol Genet. 1998;7:679-84 pubmed..We found a specific interaction between the XNP and the EZH2 proteins. In light of these observations, we discuss how the XNP protein may regulate gene transcription at the chromatin level. ..
- Le Lay S, Krief S, Farnier C, Lefrere I, Le Liepvre X, Bazin R, et al. Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes. J Biol Chem. 2001;276:16904-10 pubmed..This is the first evidence that intracellular cholesterol might serve as a link between fat cell size and adipocyte metabolic activity. ..
- Chambrey R, St John P, Eladari D, Quentin F, Warnock D, Abrahamson D, et al. Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs. Am J Physiol Renal Physiol. 2001;281:F707-17 pubmed..Nevertheless, these two proteins exhibited dramatically different affinities for intracellular H+, suggesting that they may play distinct physiological roles in the kidney...
- Vignal E, Blangy A, Martin M, Gauthier Rouviere C, Fort P. Kinectin is a key effector of RhoG microtubule-dependent cellular activity. Mol Cell Biol. 2001;21:8022-34 pubmed..These data establish that kinectin is a key mediator of microtubule-dependent RhoG activity and suggest that kinectin also mediates RhoG- and RhoA-dependent antagonistic pathways. ..
- Desseyn J, Clavereau I, Laine A. Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4. Eur J Biochem. 2002;269:3150-9 pubmed..Based on these data, we concluded that we isolated the mouse ortholog of MUC4 we propose as Muc4. Expression studies showed that Muc4 is ubiquitous like SMC and MUC4, with highest levels of expression in trachea and intestinal tract. ..
- Sebaai N, Lesage J, Alaoui A, Dupouy J, Deloof S. Effects of dehydration on endocrine regulation of the electrolyte and fluid balance and atrial natriuretic peptide-binding sites in perinatally malnourished adult male rats. Eur J Endocrinol. 2002;147:835-48 pubmed..Perinatal malnutrition also affects the responsiveness to water deprivation with alterations in both hypothalamic VP gene expression and regulation of ANP-binding sites. ..
- Germain E, Auger J, Ginies C, Siess M, Teyssier C. In vivo metabolism of diallyl disulphide in the rat: identification of two new metabolites. Xenobiotica. 2002;32:1127-38 pubmed..Only AMSO and AMSO(2) are significantly excreted in urine. 4. These potential metabolites are thought to be active in the target tissues. Our data warrant further studies to check this hypothesis. ..
- Lacroix M, Gaudichon C, Martin A, Morens C, Mathe V, Tome D, et al. A long-term high-protein diet markedly reduces adipose tissue without major side effects in Wistar male rats. Am J Physiol Regul Integr Comp Physiol. 2004;287:R934-42 pubmed..Our study suggests that the long-term consumption of an HP diet in male rats has no deleterious effects and could prevent metabolic syndrome. ..
- Laschet J, Minier F, Kurcewicz I, Bureau M, Trottier S, Jeanneteau F, et al. Glyceraldehyde-3-phosphate dehydrogenase is a GABAA receptor kinase linking glycolysis to neuronal inhibition. J Neurosci. 2004;24:7614-22 pubmed..Our results provide a molecular mechanism for the direct involvement of glycolysis in neurotransmission. ..
- Monlezun S, Ouali S, Poulain D, Theodosis D. Polysialic acid is required for active phases of morphological plasticity of neurosecretory axons and their glia. Mol Cell Neurosci. 2005;29:516-24 pubmed..PSA, therefore, by promoting dynamic cell interactions, is necessary for plasticity of axons and their associated glia. ..
- Pifferi F, Roux F, Langelier B, Alessandri J, Vancassel S, Jouin M, et al. (n-3) polyunsaturated fatty acid deficiency reduces the expression of both isoforms of the brain glucose transporter GLUT1 in rats. J Nutr. 2005;135:2241-6 pubmed..These results suggest that the decreased glucose utilization in the cerebral cortex of (n-3) PUFA-deficient rats is due to reduced amounts of the 2 isoforms of GLUT1, indicating post-transcriptional regulation of GLUT1 synthesis. ..
- Fernandes S, Amirault J, Lande G, Nguyen J, Forest V, Bignolais O, et al. Autologous myoblast transplantation after myocardial infarction increases the inducibility of ventricular arrhythmias. Cardiovasc Res. 2006;69:348-58 pubmed..However, these trials were hampered by unexpected episodes of life-threatening ventricular tachyarrhythmias (VT). We investigated cardiac electrical stability after myoblast transplantation to the myocardium...
- Pierra C, Amador A, Benzaria S, Cretton Scott E, D Amours M, Mao J, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006;49:6614-20 pubmed
- Benard G, Faustin B, Galinier A, Rocher C, Bellance N, Smolkova K, et al. Functional dynamic compartmentalization of respiratory chain intermediate substrates: implications for the control of energy production and mitochondrial diseases. Int J Biochem Cell Biol. 2008;40:1543-54 pubmed publisher..The dynamic nature of the mitochondrial network may modulate this compartmentalization and could play a new role in the control of mitochondrial respiration as well as apoptosis. ..
- Canu M, Carnaud M, Picquet F, Goutebroze L. Activity-dependent regulation of myelin maintenance in the adult rat. Brain Res. 2009;1252:45-51 pubmed publisher..These results suggest that regulation of myelin maintenance undergoes plastic mechanisms. Neural activity and/or neural pattern might be essential in the maintenance of myelin sheath in adults. ..
- Candela P, Gosselet F, Miller F, Buee Scherrer V, Torpier G, Cecchelli R, et al. Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro. Endothelium. 2008;15:254-64 pubmed publisher..These results could provide clues to physiological functions of caveolae-caveosome transcellular pathway in brain capillary ECs and may help in the rational design of more effective therapeutic drugs to the brain. ..
- Leggio G, Cathala A, Neny M, Rouge Pont F, Drago F, Piazza P, et al. In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. J Neurochem. 2009;111:614-23 pubmed publisher
- Bois C, Delalande C, Nurmio M, Parvinen M, Zanatta L, Toppari J, et al. Age- and cell-related gene expression of aromatase and estrogen receptors in the rat testis. J Mol Endocrinol. 2010;45:147-59 pubmed publisher..Therefore, the stage-regulated expression of aromatase and ESR1 genes in the rat testis suggests a likely role of estrogens in spermatogenesis. ..
- Quillard T, Devalliere J, Coupel S, Charreau B. Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction. Biochem Pharmacol. 2010;80:2032-41 pubmed publisher..Thus, here we provide evidence for a role of soluble mediators of inflammation (i.e. cytokines) in the regulation of Notch signaling and for the implication of a dysregulated Notch pathway to endothelial and vascular dysfunction. ..
- Colomer C, Martin A, Desarménien M, Guerineau N. Gap junction-mediated intercellular communication in the adrenal medulla: an additional ingredient of stimulus-secretion coupling regulation. Biochim Biophys Acta. 2012;1818:1937-51 pubmed publisher..This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics...
- Denery Papini S, Bodinier M, Larre C, Brossard C, Pineau F, Triballeau S, et al. Allergy to deamidated gluten in patients tolerant to wheat: specific epitopes linked to deamidation. Allergy. 2012;67:1023-32 pubmed publisher..Allergy to DG is a separate entity from wheat allergy. It can be evidenced by strong IgE binding to deamidated gliadins or peptides of the type QPEEPFPE. ..
- Plaisancie P, Claustre J, Estienne M, Henry G, Boutrou R, Paquet A, et al. A novel bioactive peptide from yoghurts modulates expression of the gel-forming MUC2 mucin as well as population of goblet cells and Paneth cells along the small intestine. J Nutr Biochem. 2013;24:213-21 pubmed publisher..We conclude that the peptide ?-CN(94-123) present in yoghurts may maintain or restore intestinal homeostasis and could play an important role in protection against damaging agents of the intestinal lumen...
- Dahan D, Ducret T, Quignard J, Marthan R, Savineau J, Esteve E. Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol. 2012;303:L824-33 pubmed publisher..This study provides new insights onto the complex calcium signaling in PASMC and point out the importance of the TRPV4-RyR2 signaling pathway under hypoxic conditions that may lead to pulmonary hypertension...
- Bouzidi N, Deokar H, Vogrig A, Boucherle B, Ripoche I, Abrunhosa Thomas I, et al. Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents. Bioorg Med Chem Lett. 2013;23:2624-7 pubmed publisher..The analgesic activity of the best ligand, quinoline 2, was evaluated in vivo in a model of neuropathic pain and showed promising results. ..
- Richard T, Papastamoulis Y, Waffo Teguo P, Monti J. 3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol ?-viniferin glucoside: implications in Alzheimer's disease. Biochim Biophys Acta. 2013;1830:5068-74 pubmed publisher..Even though this interaction might be important at the biological level to explain the protective effect of polyphenols in neurodegenerative diseases, caution is required when extrapolating this in vitro model to human physiology. ..
- Thurieau C, Brosius J, Burne C, Jolles P, Keen J, Mattaliano R, et al. Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles. DNA. 1988;7:663-9 pubmed..Comparison with the partially sequenced bovine brain AP50 shows a primary structure that is highly conserved. AP50 does not have detectable sequence similarity with other known kinases or with other proteins of known sequence. ..
- Atkinson J, Sautel M, Sonnay M, Fluckiger J, de Rivaz J, Boillat N, et al. Greater vasodepressor sensitivity to nicardipine in spontaneously hypertensive rats (SHR) compared to normotensive rats. Naunyn Schmiedebergs Arch Pharmacol. 1988;337:471-6 pubmed..This suggests that hypertension may be accompanied by an increase in the sensitivity of peripheral resistance beds to calcium entry blockers. ..
- Wijkhuisen A, Djouadi F, Vilar J, Merlet Benichou C, Bastin J. Birth-related changes in energy metabolism enzymes and Na-K-ATPase in kidney proximal convoluted tubule cells. Am J Physiol. 1997;272:C787-93 pubmed
- Michel D, Chatelain G, North S, Brun G. Stress-induced transcription of the clusterin/apoJ gene. Biochem J. 1997;328 ( Pt 1):45-50 pubmed..These findings provide a possible explanation for the high sensitivity of clusterin expression to environmental changes and allow the classification of clusterin as an extracellular version of heat-shock protein. ..
- Benayoun B, Esnard Feve A, Castella S, Courty Y, Esnard F. Rat seminal vesicle FAD-dependent sulfhydryl oxidase. Biochemical characterization and molecular cloning of a member of the new sulfhydryl oxidase/quiescin Q6 gene family. J Biol Chem. 2001;276:13830-7 pubmed
- Hardy G, Stanke Labesque F, Peoc h M, Hakim A, Devillier P, Caron F, et al. Cysteinyl leukotrienes modulate angiotensin II constrictor effects on aortas from streptozotocin-induced diabetic rats. Arterioscler Thromb Vasc Biol. 2001;21:1751-8 pubmed
- Tsimaratos M, Coste T, Djemli Shipkolye A, Vague P, Pieroni G, Raccah D. Gamma-linolenic acid restores renal medullary thick ascending limb Na(+),K(+)-ATPase activity in diabetic rats. J Nutr. 2001;131:3160-5 pubmed
- Ansoborlo E, Chazel V, Henge Napoli M, Pihet P, Rannou A, Bailey M, et al. Determination of the physical and chemical properties, biokinetics, and dose coefficients of uranium compounds handled during nuclear fuel fabrication in France. Health Phys. 2002;82:279-89 pubmed..Finally, the lung retention kinetics and urinary excretion rates for inhaled U03 were compared using material-specific and default absorption parameters, in order to give a practical example of the application of this study...
- Aresta S, de Tand Heim M, Beranger F, de Gunzburg J. A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases. Biochem J. 2002;367:57-65 pubmed..These findings suggest that the signalling pathways controlled by two proteins of the Ras superfamily, RhoA and Gem, are linked via the action of the RhoGAP protein Gmip (Gem-interacting protein). ..
- Tamion F, Richard V, Lacoume Y, Thuillez C. Intestinal preconditioning prevents systemic inflammatory response in hemorrhagic shock. Role of HO-1. Am J Physiol Gastrointest Liver Physiol. 2002;283:G408-14 pubmed..These results suggest that intestinal ischemia-reperfusion is a major trigger for inflammatory response and organ injury in nonseptic shock. HO-1 appears to play an important role in the protective effect of intestinal preconditioning. ..
- Chantoux F, Francon J. Thyroid hormone regulates the expression of NeuroD/BHF1 during the development of rat cerebellum. Mol Cell Endocrinol. 2002;194:157-63 pubmed..This regulation may constitute an early event in the control of differentiation of the cerebellar granular neurones by TH. ..
- Millan M, Gobert A, Lejeune F, Dekeyne A, Newman Tancredi A, Pasteau V, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003;306:954-64 pubmed..In conclusion, in contrast to melatonin, agomelatine behaves as an antagonist at 5-HT2B and 5-HT2C receptors: blockade of the latter reinforces frontocortical adrenergic and dopaminergic transmission. ..
- Malaterre J, Strambi C, Aouane A, Strambi A, Rougon G, Cayre M. A novel role for polyamines in adult neurogenesis in rodent brain. Eur J Neurosci. 2004;20:317-30 pubmed..The present study reveals common mechanisms underlying birth of new neurons in vertebrate and invertebrate species. ..
- Triqueneaux G, Thenot S, Kakizawa T, Antoch M, Safi R, Takahashi J, et al. The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker. J Mol Endocrinol. 2004;33:585-608 pubmed..Together these data demonstrate that CLOCK is a critical regulator of Rev-erbalpha circadian gene expression in evolutionarily distant vertebrates and suggest a role for Rev-erbalpha in the circadian clock output. ..
- Joyeux Faure M, Stanke Labesque F, Lefebvre B, Beguin P, Godin Ribuot D, Ribuot C, et al. Chronic intermittent hypoxia increases infarction in the isolated rat heart. J Appl Physiol (1985). 2005;98:1691-6 pubmed..Chronic IH increased heart sensitivity to infarction, independently of a significant increase in MABP, and did not affect vascular reactivity of aorta and carotid arteries. ..
- Masson E, Wiernsperger N, Lagarde M, El Bawab S. Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides. Biochem J. 2005;388:537-44 pubmed..These results document a new role of the HP in the regulation of mesangial cell growth and hypertrophy. They also suggest a potential new mechanism of action of the HP through modulation of ganglioside levels. ..
- Berthon P, Duguez S, Favier F, Amirouche A, Feasson L, Vico L, et al. Regulation of ubiquitin-proteasome system, caspase enzyme activities, and extracellular proteinases in rat soleus muscle in response to unloading. Pflugers Arch. 2007;454:625-33 pubmed..Overall, these data suggest that time-dependent regulation of intracellular and extracellular proteinases are important in setting the new phenotype of rat soleus muscle in response to HS. ..
- Barreau F, Salvador Cartier C, Houdeau E, Bueno L, Fioramonti J. Long-term alterations of colonic nerve-mast cell interactions induced by neonatal maternal deprivation in rats. Gut. 2008;57:582-90 pubmed publisher..Neonatal maternal deprivation induces closer association of colonic mast cells with nerves, which is similar to that seen in IBS patients. NGF is a possible mediator of this effect. ..
- Carette D, Gilleron J, Decrouy X, Fiorini C, Diry M, Segretain D, et al. Connexin 33 impairs gap junction functionality by accelerating connexin 43 gap junction plaque endocytosis. Traffic. 2009;10:1272-85 pubmed publisher..It is suggested that alteration of Cx43/ZO-1 association by Cx33 could be one mechanism by which Cx33 exerts its dominant-negative effect on gap junction plaque. ..
- Vaquette C, Kahn C, Frochot C, Nouvel C, Six J, De Isla N, et al. Aligned poly(L-lactic-co-e-caprolactone) electrospun microfibers and knitted structure: a novel composite scaffold for ligament tissue engineering. J Biomed Mater Res A. 2010;94:1270-82 pubmed publisher..Therefore, these scaffolds presented attractive properties for a future use in bioreactors for ligament tissue engineering. ..
- Meyer F, Louilot A. Latent inhibition-related dopaminergic responses in the nucleus accumbens are disrupted following neonatal transient inactivation of the ventral subiculum. Neuropsychopharmacology. 2011;36:1421-32 pubmed publisher..These findings may provide new insight into the pathophysiology of schizophrenia. ..
- Pain F, L heureux B, Gurden H. Visualizing odor representation in the brain: a review of imaging techniques for the mapping of sensory activity in the olfactory glomeruli. Cell Mol Life Sci. 2011;68:2689-709 pubmed publisher..We conclude this review by describing promising technical developments in optical imaging and future directions in the study of olfactory spatiotemporal coding. ..
- Ma Y, Wang X, Huang Y, Marie H, Nestler E, Schlüter O, et al. Re-silencing of silent synapses unmasks anti-relapse effects of environmental enrichment. Proc Natl Acad Sci U S A. 2016;113:5089-94 pubmed publisher..Consequently, incubation of cocaine craving was decreased persistently. These results reveal a mechanistic basis through which the persistent anti-relapse effects of EE can be unleashed after drug withdrawal. ..
- Choi D, Colas J, Kellermann O, Loric S, Launay J, Rosay P, et al. The mouse 5-HT2B receptor: possible involvement in trophic functions of serotonin. Cell Mol Biol (Noisy-le-grand). 1994;40:403-11 pubmed..Therefore, this receptor could account at least in part for the trophic functions attributed to the 5-HT2-like receptors. ..
- Duchamp Viret P, Chaput M, Duchamp A. Odor response properties of rat olfactory receptor neurons. Science. 1999;284:2171-4 pubmed..Individual olfactory receptor neurons were broadly responsive to qualitatively distinct odor compounds. We conclude that peripheral coding is based on activated arrays of olfactory receptor cells with overlapping tuning profiles. ..
- Meslin J, Fontaine N, Andrieux C. Variation of mucin distribution in the rat intestine, caecum and colon: effect of the bacterial flora. Comp Biochem Physiol A Mol Integr Physiol. 1999;123:235-9 pubmed..These variations in the contents may reflect the bacterial mucolytic activity and the effect of bacterial metabolites on the mucosa. ..
- Bernard V, Levey A, Bloch B. Regulation of the subcellular distribution of m4 muscarinic acetylcholine receptors in striatal neurons in vivo by the cholinergic environment: evidence for regulation of cell surface receptors by endogenous and exogenous stimulation. J Neurosci. 1999;19:10237-49 pubmed..Such regulation, by modulating availability of receptor for endogenous and exogenous ligands, may play key roles in the response of target neurons. ..
- Maingret F, Patel A, Lazdunski M, Honore E. The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. EMBO J. 2001;20:47-54 pubmed..TASK-1 constitutes a novel sensitive molecular target for this endocannabinoid. ..
- Jamen F, Puech R, Bockaert J, Brabet P, Bertrand G. Pituitary adenylate cyclase-activating polypeptide receptors mediating insulin secretion in rodent pancreatic islets are coupled to adenylate cyclase but not to PLC. Endocrinology. 2002;143:1253-9 pubmed..These results clearly show that the insulinotropic effect of PACAP involved both VPAC and PAC1. The PAC1 variants expressed in rat and mouse pancreatic islets seem to be coupled to adenylate cyclase but not to PLC. ..
- Brucato S, Bocquet J, Villers C. Regulation of glypican-1, syndecan-1 and syndecan-4 mRNAs expression by follicle-stimulating hormone, cAMP increase and calcium influx during rat Sertoli cell development. Eur J Biochem. 2002;269:3461-9 pubmed..Our data indicated that the regulation of HSPG mRNA expression is HSPG-specific and depends on the Sertoli cell developmental stage. ..
- Debruyne D, Sobrio F, Hinschberger A, Camsonne R, Coquerel A, Barre L. Short-term pharmacokinetics and brain distribution of mecamylamine as a preliminary to carbon-11 labeling for nicotinic receptor investigation. J Pharm Sci. 2003;92:1051-7 pubmed..Thus, mecamylamine shows peculiar qualities making it a good candidate for carbon-11 labeling for experimental studies in view of final PET imaging. ..
- Gonthier M, Donovan J, Texier O, Felgines C, Remesy C, Scalbert A. Metabolism of dietary procyanidins in rats. Free Radic Biol Med. 2003;35:837-44 pubmed..This will have to be considered to explain the health effects of procyanidins. The contribution of their microbial metabolites should also be further investigated. ..
- Mezzarobba V, Torrent A, Leydier I, Alles S, Brajon B, Mignon M, et al. The role of adrenal hormones in the response of glutamine synthetase to fasting in adult and old rats. Clin Nutr. 2003;22:569-75 pubmed..Adrenalectomy, but surprisingly not RU38486, suppressed the fasting-induced increase in GS activity and expression. The data clearly show that the GS responsiveness to fasting was not modified by aging in skeletal muscle. ..
- Dupuis M, Levy A, Mhaouty Kodja S. Functional coupling of rat myometrial alpha 1-adrenergic receptors to Gh alpha/tissue transglutaminase 2 during pregnancy. J Biol Chem. 2004;279:19257-63 pubmed..In this context, pregnant rat myometrium provides an interesting physiological model to study the mechanisms underlying the regulation of the GTPase function of Gh alpha ..
- Fiorini C, Mograbi B, Cronier L, Bourget I, Decrouy X, Nebout M, et al. Dominant negative effect of connexin33 on gap junctional communication is mediated by connexin43 sequestration. J Cell Sci. 2004;117:4665-72 pubmed..In the testis, connexin33 could exert a specific role on germ cell proliferation by suppressing the regulatory effect of connexin43. ..
- Garnier A, Bendall J, Fuchs S, Escoubet B, Rochais F, Hoerter J, et al. Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice. Circulation. 2004;110:1819-25 pubmed..However, coronary dysfunction may be harmful for coronary adaptation to increased flow demand. ..
- Deschaux O, Bizot J. Apamin produces selective improvements of learning in rats. Neurosci Lett. 2005;386:5-8 pubmed..These results suggest that the blockade of SK channels could improve the acquisition but not when the task requires the processing of spatial information. ..
- De Doncker L, Kasri M, Picquet F, Falempin M. Physiologically adaptive changes of the L5 afferent neurogram and of the rat soleus EMG activity during 14 days of hindlimb unloading and recovery. J Exp Biol. 2005;208:4585-92 pubmed..To conclude, our study directly demonstrates that the HU conditions cannot be considered as a functional deafferentation, as suggested in the literature, but only as a reduction of afferent information at the beginning of the HU period. ..
- Broccardo C, Nieoullon V, Amin R, Masmejean F, Carta S, Tassi S, et al. ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain. J Neurochem. 2006;97:345-55 pubmed..Considering that the latter are targets of Alzheimer's lesions, these data provide a new rationale to explore the neuropathological consequences of ABCA2 functional dysregulations...
- Gremy O, Benderitter M, Linard C. Caffeic acid phenethyl ester modifies the Th1/Th2 balance in ileal mucosa after gamma-irradiation in the rat by modulating the cytokine pattern. World J Gastroenterol. 2006;12:4996-5004 pubmed..CAPE amplified apoptotic events at 6 h and normalized Bax/FasL expressions at 7 d. CAPE prevented the ileal Th2 immune response by modulating the irradiation-influenced cytokine environment and apoptosis. ..
- Viranaicken W, Gasmi L, Chauvin C, Denoulet P, Larcher J. Identification of a newly spliced exon in the mouse Ilf3 gene generating two long and short isoforms of Ilf3 and NF90. Genomics. 2006;88:622-32 pubmed..By RT-PCR, no other variants were found. Combining our results and GenBank sequences, we determined the exon-intron organization of the entire mouse Ilf3 gene divided into 22 exons. ..
- Barbier J, Rannou Bekono F, Marchais J, Tanguy S, Carre F. Alterations of beta3-adrenoceptors expression and their myocardial functional effects in physiological model of chronic exercise-induced cardiac hypertrophy. Mol Cell Biochem. 2007;300:69-75 pubmed..Classical negative myocardial lusitropic and inotropic effects induced by a specific agonist of beta(3) AR were diminished in trained rats. ..
- Chambraud B, Belabes H, Fontaine Lenoir V, Fellous A, Baulieu E. The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation. FASEB J. 2007;21:2787-97 pubmed..Collectively, our data define an unexpected property of FKBP52 as a novel regulator of microtubule dynamics. The possible role of microtubule formation and tubulin binding of other immunophilins such as FKBP12 and FKBP51 is discussed. ..
- Pieraut S, Boukhaddaoui H, Scamps F, Dayanithi G, Sieso V, Valmier J. Spontaneous glutamate release controls NT-3-dependent development of hippocampal calbindin-D(28k) phenotype through activation of sodium channels ex vivo. Eur J Neurosci. 2007;25:2629-39 pubmed
- Ducroc R, Voisin T, El Firar A, Laburthe M. Orexins control intestinal glucose transport by distinct neuronal, endocrine, and direct epithelial pathways. Diabetes. 2007;56:2494-500 pubmed..Our data delineate a new function for orexins as inhibitors of intestinal glucose absorption and provide a new basis for orexin-induced short-term control of energy homeostasis. ..
- Laalou F, de Vasconcelos A, Oberling P, Jeltsch H, Cassel J, Pain L. Involvement of the basal cholinergic forebrain in the mediation of general (propofol) anesthesia. Anesthesiology. 2008;108:888-96 pubmed publisher..These results demonstrate that a cholinergic dysfunction in the basal forebrain potentiates the anesthetic effects of propofol. ..
- Balage M, Averous J, Remond D, Bos C, Pujos Guillot E, Papet I, et al. Presence of low-grade inflammation impaired postprandial stimulation of muscle protein synthesis in old rats. J Nutr Biochem. 2010;21:325-31 pubmed publisher..Our results suggested that the control of LGI development in elderly improve meal effect on muscle protein synthesis and consequently slow down sarcopenia. ..
- Hennebelle T, Weniger B, Joseph H, Sahpaz S, Bailleul F. Senna alata. Fitoterapia. 2009;80:385-93 pubmed publisher..The laxative activity is supported by scientific findings. In contrast the dermatologic use requires further investigation. The species can be considered as safe for short-term or topical use...
- Rondón L, Privat A, Daulhac L, Davin N, Mazur A, Fialip J, et al. Magnesium attenuates chronic hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat model of diabetic neuropathic pain. J Physiol. 2010;588:4205-15 pubmed publisher..Thus, neuropathic pain symptoms can be attenuated by targeting the Mg-mediated blockade of NMDA receptors, offering new therapeutic opportunities for the management of chronic neuropathic pain...
- Dejean C, Nadjar A, Le Moine C, Bioulac B, Gross C, Boraud T. Evolution of the dynamic properties of the cortex-basal ganglia network after dopaminergic depletion in rats. Neurobiol Dis. 2012;46:402-13 pubmed publisher..While the oscillatory firing increase reflects dopaminergic depletion, response alteration in SNr neurons is closely related to motor symptom. ..
- Clement O, Sapin E, Libourel P, Arthaud S, Brischoux F, Fort P, et al. The lateral hypothalamic area controls paradoxical (REM) sleep by means of descending projections to brainstem GABAergic neurons. J Neurosci. 2012;32:16763-74 pubmed publisher..Furthermore, our results strongly suggest that these neurons trigger PS by means of their inhibitory projection to the PS-off GABAergic neurons located in the VLPAG/dDpMe. ..
- Fraysse B, Guillet C, Huchet Cadiou C, Camerino D, Gascan H, Leoty C. Ciliary neurotrophic factor prevents unweighting-induced functional changes in rat soleus muscle. J Appl Physiol (1985). 2000;88:1623-30 pubmed..The present results demonstrate that exogenously provided CNTF could prevent functional changes occurring in soleus innervated muscle subject to unweighting...