Experts and Doctors on pyrimidines in Taiwan


Locale: Taiwan
Topic: pyrimidines

Top Publications

  1. Su B, Huang Y, Chang C, Tu Y, Tseng Y. Template-based de novo design for type II kinase inhibitors and its extented application to acetylcholinesterase inhibitors. Molecules. 2013;18:13487-509 pubmed publisher
    ..This template-based lead optimization protocol with the fragment library can help to design compounds with preferred binding interactions of known inhibitors automatically and further optimize the compounds in the binding pockets. ..
  2. Lin C, Lin C, Chen K, Wu J, Huang S, Wang S. Macrophage activation increases the invasive properties of hepatoma cells by destabilization of the adherens junction. FEBS Lett. 2006;580:3042-50 pubmed
    ..Our results suggest that activated macrophages have a tumor-progressive effect on HepG2 cells which involves the c-Src- and EGFR-dependent signaling cascades. ..
  3. Chou C, Hsu S, Chen M, Chen M, Shih Y, Lee L, et al. Idiopathic hypereosinophilic syndrome with infiltration of cerebrospinal fluid by immature eosinophils: a case report and literature review. Surg Neurol. 2007;68 Suppl 1:S52-5; discussion S55 pubmed
  4. Yang W, Kuo M, Liu C, Deng Y, Chang H, Chang J. Curcumin inhibits TGF?1-induced CCN2 via Src, JNK, and Smad3 in gingiva. J Dent Res. 2013;92:629-34 pubmed publisher
    ..Furthermore, curcumin inhibited TGF?1-induced HGF migration and ?-SMA expression. Curcumin potentially qualifies as a useful agent for the control of GO. ..
  5. Yang K, Wang M, Chen J, Hsu M, Hung W. Bcr-Abl oncogene stimulates Jab1 expression via cooperative interaction of ?-catenin and STAT1 in chronic myeloid leukemia cells. J Cell Physiol. 2011;226:2849-56 pubmed publisher
    ..Taken together, our results suggest that Bcr-Abl stimulates Jab1 expression via the cooperative interaction of ?-catenin and STAT1 in leukemia cells. ..
  6. Chang S, Shen S, Lee W, Yang L, Chen Y. Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells. J Dermatol Sci. 2011;62:183-91 pubmed publisher
    ..Our results support the idea that ROS-dependent apoptosis in STI571-treated melanoma cells B16F0. The combination of a JNK inhibitor with STI571 for treating melanomas is suggested for further in vivo studies. ..
  7. Chiang L, Tseng I, Lin P, Sheu S, Lin C, Hsieh Y, et al. Synthesis of Canthardin Sulfanilamides and Their Acid Anhydride Analogues via a Ring-Opening Reaction of Activated Aziridines and Their Associated Pharmacological Effects. Molecules. 2016;21:100 pubmed publisher
    ..Two compounds 5g and 5h displayed slight effects on the Hep3B cell line, while the other compounds produced no response in these four cell lines. ..
  8. Tsai J, Chen C, Chen Y, Chuang L. Rosiglitazone inhibits monocyte/macrophage adhesion through de novo adiponectin production in human monocytes. J Cell Biochem. 2010;110:1410-9 pubmed publisher
    ..Our data suggest that the inhibitory effect of RSG on monocyte adhesion might be at least in part through de novo adiponectin expression and activation of an AMPK-dependent pathway, which might play an important role in atherogenesis. ..
  9. Liu J, Liu C, Yen C, Gau J, Wang W, Tzeng C. Pml and TAp73 interacting at nuclear body mediate imatinib-induced p53-independent apoptosis of chronic myeloid leukemia cells. Int J Cancer. 2009;125:71-7 pubmed publisher
    ..A novel p53-independent proapoptotic mechanism using p38 MAPK /pml/TAp73 axis with a step processing at PML-NB and probably with chk2 and bax being involved is hereby evident in some imatinib-treated CML cells. ..

More Information


  1. Chang C, Yang Y, Hsu C, Lin M. Trends in the treatment changes and medication persistence of chronic myeloid leukemia in Taiwan from 1997 to 2007: a longitudinal population database analysis. BMC Health Serv Res. 2012;12:359 pubmed publisher
    ..Our study also highlights the need to improve treatment persistence and effectiveness of imatinib over the long term. ..
  2. Wang T, Li W, Yu S, Au L. The use of 10-23 DNAzyme to selectively destroy the allele of mRNA with a unique purine-pyrimidine dinucleotide. Oligonucleotides. 2008;18:295-9 pubmed publisher
    ..This proof-of-concept experiment provided a new way to knock down expression of a given allele with special single-base transversion. ..
  3. Hsieh C, Jeng J, Hsieh M, Chen Y, Lu T, Rau C, et al. Involvement of the p38 pathway in the differential induction of heme oxygenase-1 by statins in Neuro-2A cells exposed to lipopolysaccharide. Drug Chem Toxicol. 2011;34:8-19 pubmed publisher
    ..This study demonstrated the involvement of p38 in the differential induction of HO-1 by different statins and showed the different physiological relevance of experiments on different cell types. ..
  4. Lin Y, Wu M, Wei T, Chuang S, Chen K, Cheng A, et al. Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells. Neoplasia. 2012;14:463-75 pubmed
    ..In conclusion, degradation of EGFR is a novel mechanism responsible for dasatinib-induced apoptosis in HNSCC cells. ..
  5. Chen R, Chang W, Lin Y, Cheng P, Chen Y. Alzheimer's amyloid-? oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway. ACS Chem Neurosci. 2013;4:1287-96 pubmed publisher
    ..Overall, our results demonstrated that PrP(C) down-regulated tau via the Fyn pathway and the effect can be regulated by A? oligomers. Our study facilitated the understanding of molecular mechanisms among PrP(C), tau, and A? oligomers. ..
  6. Chen C, Cheng C, Chen Y, Sue Y, Hsu Y, Tsai W, et al. Rosuvastatin inhibits pressure-induced fibrotic responses via the expression regulation of prostacyclin and prostaglandin E2 in rat renal tubular cells. Eur J Pharmacol. 2013;700:65-73 pubmed publisher
    ..In conclusion, rosuvastatin reduces pressure-induced fibrotic responses in renal tubular cells by enhancing the PGI(2)-peroxisome proliferator-activated receptor ? pathway and reducing PGE(2) generation. ..
  7. Chang W, Liu T, Yang W, Lee C, Lin Y, Chen T, et al. Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib. Cancer Res. 2011;71:383-92 pubmed publisher
    ..Our findings suggest that amiloride may offer a potential treatment option for chronic myelogenous leukemia either alone or in combination with imatinib. ..
  8. Lin C, Yen R, Jeng Y, Tzen C, Hsu C, Hong R. Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate. Head Neck. 2005;27:1022-7 pubmed
    ..We observed an unexpected high progression rate of metastatic ACC within short periods during imatinib treatment. Use of imatinib to treat cancers without c-kit or PDGFR-alpha mutation should be approached with caution. ..
  9. Chen T, Yu M, Chien C, Wu M, Lee Y, Chen Y. Nilotinib reduced the viability of human ovarian cancer cells via mitochondria-dependent apoptosis, independent of JNK activation. Toxicol In Vitro. 2016;31:1-11 pubmed publisher
    ..The evidence supporting AMN effectively reducing the viability of human ovarian cancer cells via mitochondrion-dependent apoptosis is provided. ..
  10. Yang S, Chang S, Wen H, Chen C, Liao J, Chang C. Plumbagin activates ERK1/2 and Akt via superoxide, Src and PI3-kinase in 3T3-L1 cells. Eur J Pharmacol. 2010;638:21-8 pubmed publisher
    ..These results suggest that plumbagin activates NAD(P)H oxidase, Src, and PI3K, and that the activated PI3K or PDK1 subsequently stimulate Akt and Ras-Raf-MEK1/2-ERK1/2 in 3T3-L1 cells. ..
  11. Tsai T, Wu S, Chang Y, Wu C, Tsai M, Wei P, et al. Effusion immunocytochemistry as an alternative approach for the selection of first-line targeted therapy in advanced lung adenocarcinoma. J Thorac Oncol. 2012;7:993-1000 pubmed publisher
  12. Yu H, Lin C, Tai W, Liu C, Shiau C, Chen K. Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation. J Biol Chem. 2013;288:18249-59 pubmed publisher
    ..Together, our results reveal that nilotinib induces autophagy, but not apoptosis in HCC, and that the autophagy-inducing activity is associated with PP2A-regulated AMPK phosphorylation. ..
  13. Chung T, Wang S, Liang J, Yang S, Wu J. The interaction of estrogen receptor alpha and caveolin-3 regulates connexin43 phosphorylation in metabolic inhibition-treated rat cardiomyocytes. Int J Biochem Cell Biol. 2009;41:2323-33 pubmed publisher
  14. Lee Y, Chen C, Liu F, Huang Y, Huang H. Aclacinomycin A sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. PLoS ONE. 2013;8:e61939 pubmed publisher
    ..These results provided a potential management by which ACM might have a crucial impact on increasing sensitivity of CML cells to imatinib in the differentiation therapeutic approaches. ..
  15. Huang W, Chen J, Inoue H, Chen C. Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression. J Immunol. 2003;170:4767-75 pubmed
    ..These two pathways cross-link between c-Src and NIK and converge at IKKalpha/beta, and go on to activate NF-kappaB, via serine phosphorylation and degradation of IkappaB-alpha, and, finally, to initiate COX-2 expression. ..
  16. Ko T, Lin J, Hu C, Hsu Y, Wang A, Liaw S. Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution. J Biol Chem. 2003;278:19111-7 pubmed
  17. Tang C, Yang R, Fu W. Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts. J Biol Chem. 2005;280:22907-16 pubmed
    ..Taken together, our results provided evidence that PGE(2) increased Fn and promoted bone formation in rat osteoblasts via the EP(1)/phospholipase C/PKCalpha/c-Src signaling pathway. ..
  18. Huang D, Chao Y, Tai M, Yu Y, Lin W. STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death. J Biomed Sci. 2012;19:35 pubmed publisher
    ..Our results raise additional concerns when developing combination cancer therapy with TRAIL and STI571 in the future. ..
  19. Su K, Yu Y, Hou H, Zhao J, Kou Y, Cheng L, et al. AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase. J Cell Physiol. 2012;227:3053-62 pubmed publisher
    ..Taken together, EPO may trigger AMPK-dependent signaling, which leads to enhanced phosphorylation of ?CR and eNOS, increased ?CR-AMPK-eNOS complex formation, NO production, and, ultimately, angiogenesis. ..
  20. Lin J, Tarn W. Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB. Mol Cell Biol. 2005;25:10111-21 pubmed
    ..This study suggests a possible mechanism underlying the regulated alternative splicing of alpha-TM by the antagonistic splicing regulators RBM4 and PTB. ..
  21. Hou C, Fong Y, Tang C. HMGB-1 induces IL-6 production in human synovial fibroblasts through c-Src, Akt and NF-?B pathways. J Cell Physiol. 2011;226:2006-15 pubmed publisher
    ..Our results suggest that HMGB-1-increased IL-6 production in human synovial fibroblasts via the RAGE receptor, c-Src, Akt, p65, and NF-?B signaling pathways. ..
  22. Kuo Y, Chang Z. GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription. Mol Cell Biol. 2007;27:4261-72 pubmed
    ..These findings illuminate the role of Gfi-1B in GATA-1-mediated transcription in the survival aspect of erythroid cells. ..