Experts and Doctors on protein transport in United States


Locale: United States
Topic: protein transport

Top Publications

  1. Tan B, Cline K, McCarty D. Localization and targeting of the VP14 epoxy-carotenoid dioxygenase to chloroplast membranes. Plant J. 2001;27:373-82 pubmed
    ..1 M Na2CO3 (pH 11.5) and 6 M urea. Unlabelled recombinant VP14 inhibited the tight binding of imported VP14, suggesting that VP14 is associated with specific components of the thylakoid membrane. ..
  2. Shi N, Ye B, Makielski J. Function and distribution of the SUR isoforms and splice variants. J Mol Cell Cardiol. 2005;39:51-60 pubmed
    ..x subunits. The different isoforms and splice variants allow for many K(ATP) channel combinations, and therefore, increases the channel diversity and the possibility of complexity in function. ..
  3. Goel M, Sinkins W, Zuo C, Hopfer U, Schilling W. Vasopressin-induced membrane trafficking of TRPC3 and AQP2 channels in cells of the rat renal collecting duct. Am J Physiol Renal Physiol. 2007;293:F1476-88 pubmed
  4. Pollard A, Onatolu K, Hiller L, Haldar K, Knoll L. Highly polymorphic family of glycosylphosphatidylinositol-anchored surface antigens with evidence of developmental regulation in Toxoplasma gondii. Infect Immun. 2008;76:103-10 pubmed
    ..This group of proteins likely represents a new family of polymorphic GPI-anchored surface antigens that are recognized by the host's immune system and whose expression is regulated during infection. ..
  5. Manson M, Corey D, White N, Kelley T. cAMP-mediated regulation of cholesterol accumulation in cystic fibrosis and Niemann-Pick type C cells. Am J Physiol Lung Cell Mol Physiol. 2008;295:L809-19 pubmed publisher
  6. Fazal F, Bijli K, Minhajuddin M, Rein T, Finkelstein J, Rahman A. Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells. J Biol Chem. 2009;284:21047-56 pubmed publisher
    ..Together, these data show that cofilin-1 occupies a central position in RhoA-actin pathway mediating nuclear translocation of RelA/p65 and expression of ICAM-1 in endothelial cells. ..
  7. Stuart C, Howell M, Zhang Y, Yin D. Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle. J Clin Endocrinol Metab. 2009;94:3535-42 pubmed publisher
    ..Translocation of GLUT12 in cultured myoblasts was dependent on activation of PI3-K. GLUT12 may have evolutionarily preceded GLUT4 and now provides redundancy to the dominant GLUT4 system in muscle. ..
  8. Grillo C, Piroli G, Hendry R, Reagan L. Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent. Brain Res. 2009;1296:35-45 pubmed publisher
  9. Pomeranz M, Hah C, Lin P, Kang S, Finer J, Blackshear P, et al. The Arabidopsis tandem zinc finger protein AtTZF1 traffics between the nucleus and cytoplasmic foci and binds both DNA and RNA. Plant Physiol. 2010;152:151-65 pubmed publisher
    ..Since AtTZF1 can bind both DNA and RNA in vitro, it raises the possibility that AtTZF1 might be involved in DNA and/or RNA regulation. ..

More Information

Publications793 found, 100 shown here

  1. Srinivasan R, Pantoja R, Moss F, Mackey E, Son C, Miwa J, et al. Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. J Gen Physiol. 2011;137:59-79 pubmed publisher
    ..The data also suggest that pharmacological chaperoning of nAChRs by nicotine can alter the physiology of ER processes. ..
  2. Liu S, Madiai F, Hackshaw K, Allen C, Carl J, Huschart E, et al. The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis. PLoS ONE. 2011;6:e17161 pubmed publisher
  3. Hein P, Palangat M, Landick R. RNA transcript 3'-proximal sequence affects translocation bias of RNA polymerase. Biochemistry. 2011;50:7002-14 pubmed publisher
  4. Piao H, Maclean Freed J, Mayinger P. Metabolic activation of the HOG MAP kinase pathway by Snf1/AMPK regulates lipid signaling at the Golgi. Traffic. 2012;13:1522-31 pubmed publisher
    ..We conclude that a novel cross-talk between the HOG pathway and Snf1/AMPK is required for the metabolic control of lipid signaling at the Golgi. ..
  5. Berry C, Sceniak M, Zhou L, Sabo S. Developmental up-regulation of vesicular glutamate transporter-1 promotes neocortical presynaptic terminal development. PLoS ONE. 2012;7:e50911 pubmed publisher
    ..These results demonstrate that up-regulation of VGLUT1 is important for development of presynaptic terminals in the cortex. ..
  6. You Y, Wen R, Pathak R, Li A, Li W, St Clair D, et al. Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway. Cell Death Dis. 2014;5:e1493 pubmed publisher
    ..Lxn could be a novel molecular target that improves the efficacy of anti-cancer therapy. ..
  7. Peng X, Wang J, Huan J, Wu F. Double-layer clustering method to predict protein complexes based on power-law distribution and protein sublocalization. J Theor Biol. 2016;395:186-193 pubmed publisher
  8. Park H, Ryu D, Parmar M, Giasson B, McFarland N. The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome. PLoS ONE. 2017;12:e0184262 pubmed publisher
    ..Further investigation of the mechanism of RER1 and downstream effectors on ?Syn may yield novel therapeutic targets for modulation in Parkinson disease and related synucleinopathies. ..
  9. Susan P, Dunn W. Starvation-induced lysosomal degradation of aldolase B requires glutamine 111 in a signal sequence for chaperone-mediated transport. J Cell Physiol. 2001;187:48-58 pubmed
    ..We discuss the possible roles for autophagy and hsc73-mediated transport in the lysosomal sequestration of aldolase B. ..
  10. Eichenmuller B, Kedersha N, Solovyeva E, Everley P, Lang J, Himes R, et al. Vaults bind directly to microtubules via their caps and not their barrels. Cell Motil Cytoskeleton. 2003;56:225-36 pubmed
    ..Taken together, the data support the model of vaults as barrel-shaped containers that transiently interact with microtubules. ..
  11. Schroeder L, Kremer S, Kramer M, Currie E, Kwan E, Watts J, et al. Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle. Mol Biol Cell. 2007;18:995-1008 pubmed
    ..Our results provide an explanation for the loss of Nile Red-stained fat in pgp-2(-) animals as well as insight into the specialized function of this lysosome-related organelle...
  12. Liu T, Toriyabe Y, Kazak M, Berkman C. Pseudoirreversible inhibition of prostate-specific membrane antigen by phosphoramidate peptidomimetics. Biochemistry. 2008;47:12658-60 pubmed publisher
    ..The discovery of pseudoirreversible PSMA inhibitors is expected to provide a new avenue of investigation and therapeutic applications for prostate cancer and neurological disorders. ..
  13. Herce H, Garcia A, Litt J, Kane R, Martin P, Enrique N, et al. Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell-penetrating peptides. Biophys J. 2009;97:1917-25 pubmed publisher
    ..Our results suggest that the mechanism of action of Arg-9 peptides involves the creation of transient pores in lipid bilayers and cell membranes. ..
  14. Wu B, Clarke C, Matmati N, Montefusco D, Bartke N, Hannun Y. Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. J Biol Chem. 2011;286:22362-71 pubmed publisher
    ..The analysis of interactions between nSMase2 and APLs will contribute to our understanding of signaling pathways mediated by sphingolipid metabolites. ..
  15. Siow D, Wattenberg B. The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism. Crit Rev Biochem Mol Biol. 2011;46:365-75 pubmed publisher
    ..Not only is the signaling output of the SKs affected by subcellular localization, but the role of these enzymes as metabolic regulators of sphingolipid metabolism may be impacted as well. ..
  16. Shen K, Arslan S, Akopian D, Ha T, Shan S. Activated GTPase movement on an RNA scaffold drives co-translational protein targeting. Nature. 2012;492:271-5 pubmed publisher
  17. Soysa R, Venselaar H, Poston J, Ullman B, Hasne M. Structural model of a putrescine-cadaverine permease from Trypanosoma cruzi predicts residues vital for transport and ligand binding. Biochem J. 2013;452:423-32 pubmed publisher
    ..These results support the robustness of the TcPOT1.1 homology model and reveal the importance of specific aromatic residues in the TcPOT1.1 putrescine-binding pocket...
  18. Frolov A, Dong H, Jiang M, Yang L, Cook E, Matnani R, et al. Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis. J Biol Chem. 2013;288:23696-703 pubmed publisher
  19. Rush J, Ceresa B. RAB7 and TSG101 are required for the constitutive recycling of unliganded EGFRs via distinct mechanisms. Mol Cell Endocrinol. 2013;381:188-97 pubmed publisher
    ..These two proteins regulate EGFR slow, perinuclear recycling, via distinct mechanism and are new molecular targets that regulate cell surface EGFR expression. ..
  20. Sanvisens N, Romero A, Zhang C, Wu X, An X, Huang M, et al. Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Small Subunit Localization in Response to Iron Deficiency. J Biol Chem. 2016;291:9807-17 pubmed publisher
    ..Taken together, these results reveal that, in response to iron starvation, Dun1 kinase phosphorylates Dif1 to stimulate Rnr2-Rnr4 relocalization to the cytoplasm and promote RNR function. ..
  21. Prashek J, Bouyain S, Fu M, Li Y, Berkeš D, Yao X. Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain. J Biol Chem. 2017;292:14217-14228 pubmed publisher
    ..Collectively, our structural, biochemical, and cellular investigations provide important structural insight into the regulation of CERT function and localization. ..
  22. Ujvari A, Aron R, Eisenhaure T, Cheng E, Parag H, Smicun Y, et al. Translation rate of human tyrosinase determines its N-linked glycosylation level. J Biol Chem. 2001;276:5924-31 pubmed
    ..Therefore, the rate of protein translation can regulate the level of tyrosinase N-linked glycosylation, as well as other potential cotranslational maturation events. ..
  23. Shin S, Janknecht R. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. J Cell Biochem. 2007;101:1252-65 pubmed
    ..Thereby, p72 RNA helicase may not only be involved in the p53-Mdm2 regulatory loop, but also profoundly impact on the transcriptome through various CBP/p300 and P/CAF interacting proteins. ..
  24. Cowell C, Döppler H, Yan I, Hausser A, Umezawa Y, Storz P. Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling. J Cell Sci. 2009;122:919-28 pubmed publisher
    ..However, our data describe a role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling. ..
  25. Schillace R, Miller C, Carr D. AKAPs in lipid rafts are required for optimal antigen presentation by dendritic cells. Immunol Cell Biol. 2011;89:650-8 pubmed publisher
  26. Romine M. Genome-wide protein localization prediction strategies for gram negative bacteria. BMC Genomics. 2011;12 Suppl 1:S1 pubmed publisher
  27. Tian G, Ropelewski P, Nemet I, Lee R, Lodowski K, Imanishi Y. An unconventional secretory pathway mediates the cilia targeting of peripherin/rds. J Neurosci. 2014;34:992-1006 pubmed publisher
    ..Because rhodopsin is known to traffic through conventional secretion, this study of P/rds suggests that both conventional secretion and unconventional secretion need to cooperate for the renewal of the photoreceptor sensory cilium. ..
  28. Tani M, Hannun Y. Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. J Biol Chem. 2007;282:10047-56 pubmed
    ..In summary, the results from this study reveal for the first time the palmitoylation of nSMase2 via thioester bonds and its importance in the subcellular localization and stability of this protein. ..
  29. Zhu Q, Wani G, Arab H, El Mahdy M, Ray A, Wani A. Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites. DNA Repair (Amst). 2009;8:262-73 pubmed publisher
    ..These data demonstrate that successful NER of genomic lesions and prompt CAF-1-mediated chromatin restoration link uH2A incorporation at the sites of damage repair within chromatin. ..
  30. Li C, Iida M, Dunn E, Wheeler D. Dasatinib blocks cetuximab- and radiation-induced nuclear translocation of the epidermal growth factor receptor in head and neck squamous cell carcinoma. Radiother Oncol. 2010;97:330-7 pubmed publisher
    ..Collectively these findings may suggest that dasatinib can limit EGFR translocation to the nucleus and may enhance radiotherapy plus cetuximab in HNSCC. ..
  31. Owen J, Sultana R, Aluise C, Erickson M, Price T, Bu G, et al. Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for A? accumulation in AD brain. Free Radic Biol Med. 2010;49:1798-803 pubmed publisher
    ..Based on this study, we propose that A? impairs its own efflux from the brain by oxidation of its transporter LRP1, leading to increased A? deposition in brain, thereby contributing to subsequent cognitive impairment in AD. ..
  32. Sanchez E, Lewis K, Munske G, Nissen M, Kang C. Glycosylation of skeletal calsequestrin: implications for its function. J Biol Chem. 2012;287:3042-50 pubmed publisher
    ..In addition, based on the high resolution structures, we propose a molecular mechanism for the catecholaminergic polymorphic ventricular tachycardia (CPVT2) mutation, K206N. ..
  33. Vladykovskaya E, Sithu S, Haberzettl P, Wickramasinghe N, Merchant M, Hill B, et al. Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. J Biol Chem. 2012;287:11398-409 pubmed publisher
    ..The induction of ER stress may be a significant cause of vascular inflammation induced by products of oxidized lipids. ..
  34. Brooks E, Wallingford J. Control of vertebrate intraflagellar transport by the planar cell polarity effector Fuz. J Cell Biol. 2012;198:37-45 pubmed publisher
    ..These data place Fuz in the small group of known IFT effectors outside the core machinery and, additionally, identify Fuz as a novel cytoplasmic effector that differentiates between the retrograde and anterograde IFT complexes. ..
  35. Noh B, Murphy A, Spalding E. Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development. Plant Cell. 2001;13:2441-54 pubmed
    ..The results indicate that these two MDR-like genes of Arabidopsis encode 1-naphthylphthalamic acid binding proteins that are required for normal auxin distribution and auxin-mediated development. ..
  36. Mori H, Cline K. A twin arginine signal peptide and the pH gradient trigger reversible assembly of the thylakoid [Delta]pH/Tat translocase. J Cell Biol. 2002;157:205-10 pubmed
    ..It also explains in part how the system can exist in the membrane without compromising its ion and proton permeability barrier. ..
  37. Rontein D, Wu W, Voelker D, Hanson A. Mitochondrial phosphatidylserine decarboxylase from higher plants. Functional complementation in yeast, localization in plants, and overexpression in Arabidopsis. Plant Physiol. 2003;132:1678-87 pubmed
    ..They also indicate that mitochondrial PSD is an important housekeeping enzyme whose expression is strongly regulated at the transcriptional level. ..
  38. Wisner T, Johnson D. Redistribution of cellular and herpes simplex virus proteins from the trans-golgi network to cell junctions without enveloped capsids. J Virol. 2004;78:11519-35 pubmed
    ..This is consistent with the hypothesis that there are late HSV proteins that reorganize or redistribute TGN/endosomal compartments to promote virus egress and cell-to-cell spread. ..
  39. Afaq F, Malik A, Syed D, Maes D, Matsui M, Mukhtar H. Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign. Photochem Photobiol. 2005;81:38-45 pubmed
  40. Gantt K, Cherry J, Tenney R, Karschner V, Pekala P. An early event in adipogenesis, the nuclear selection of the CCAAT enhancer-binding protein {beta} (C/EBP{beta}) mRNA by HuR and its translocation to the cytosol. J Biol Chem. 2005;280:24768-74 pubmed
    ..In support of this hypothesis, small interfering RNA suppression of HuR protein content resulted in an inhibition of C/EBPbeta protein expression and an attenuation of the differentiation process. ..
  41. Mitra K, Schaffitzel C, Shaikh T, Tama F, Jenni S, Brooks C, et al. Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature. 2005;438:318-24 pubmed
    ..On the basis of our observation in the translocating PCC of two segregated pores with different degrees of access to bulk lipid, we propose a model for co-translational protein translocation. ..
  42. Wei Q, Xia Y. Proteasome inhibition down-regulates endothelial nitric-oxide synthase phosphorylation and function. J Biol Chem. 2006;281:21652-9 pubmed
    ..Taken together, these studies identified a novel pathway in which proteasome modulates eNOS phosphorylation by inducing intracellular PP2A translocation. ..
  43. Haire S, Pang J, Boye S, Sokal I, Craft C, Palczewski K, et al. Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Invest Ophthalmol Vis Sci. 2006;47:3745-53 pubmed
  44. Amerik A, Sindhi N, Hochstrasser M. A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function. J Cell Biol. 2006;175:825-35 pubmed
    ..This is the first demonstration of a physiologically important DUB subcellular localization signal and provides a striking example of the functional diversification of DUB paralogues by the evolution of alternative spatial signals. ..
  45. Poustka F, Irani N, Feller A, Lu Y, Pourcel L, Frame K, et al. A trafficking pathway for anthocyanins overlaps with the endoplasmic reticulum-to-vacuole protein-sorting route in Arabidopsis and contributes to the formation of vacuolar inclusions. Plant Physiol. 2007;145:1323-35 pubmed
    ..Taken together, these results provide evidence for an alternative novel mechanism of vesicular transport and vacuolar sequestration of anthocyanins in Arabidopsis...
  46. Rojas Pierce M, Titapiwatanakun B, Sohn E, Fang F, Larive C, Blakeslee J, et al. Arabidopsis P-glycoprotein19 participates in the inhibition of gravitropism by gravacin. Chem Biol. 2007;14:1366-76 pubmed
    ..Gravacin is an auxin transport inhibitor that inhibits PGPs, particularly PGP19, which can be used to further dissect the role of PGP19 without the inhibition of other auxin transporters, namely PIN proteins. ..
  47. Mitra P, Audus K. MRP isoforms and BCRP mediate sulfate conjugate efflux out of BeWo cells. Int J Pharm. 2010;384:15-23 pubmed publisher
    ..BCRP played a minor role in the elimination of these two sulfate conjugates across the apical membrane. This study demonstrates that a yet undetermined role of trophoblast efflux transporters is the elimination of sulfate conjugates...
  48. Chai S, Li M, Branigan D, Xiong Z, Simon R. Activation of acid-sensing ion channel 1a (ASIC1a) by surface trafficking. J Biol Chem. 2010;285:13002-11 pubmed publisher
    ..These results reveal an important trafficking mechanism of ASIC1a that is relevant to both the normal physiology and the pathological activity of this channel. ..
  49. Kedlaya R, Kandala G, Liu T, Maddodi N, Devi S, Setaluri V. Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes. Arch Biochem Biophys. 2011;508:227-33 pubmed publisher
    ..These data suggest that interactions between TRP1-GIPC and GIPC-APPL-AKT provide a potential link between melanogenesis and PI3 kinase signaling. ..
  50. Day P, Riggs K, Hasan N, Corbin D, Humphrey D, Hu C. Syntaxins 3 and 4 mediate vesicular trafficking of ?5?1 and ?3?1 integrins and cancer cell migration. Int J Oncol. 2011;39:863-71 pubmed publisher
    ..Collectively, these data suggest that syntaxins 3- and 4-dependent integrin trafficking is important in cancer cell migration and survival, and may be a valuable target for cancer therapy. ..
  51. Werneburg N, Bronk S, Guicciardi M, Thomas L, Dikeakos J, Thomas G, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2). J Biol Chem. 2012;287:24427-37 pubmed publisher
    ..Together, these findings provide insight into the lysosomal pathway of apoptosis. ..
  52. Hsiao C, Luisa Hiller N, Haldar K, Knoll L. A HT/PEXEL motif in Toxoplasma dense granule proteins is a signal for protein cleavage but not export into the host cell. Traffic. 2013;14:519-31 pubmed publisher
    ..These findings suggest that while Toxoplasma and Plasmodium share similar HT/PEXEL motifs, Toxoplasma HT/PEXEL containing proteins interact with but do not cross the PVM. ..
  53. Slaats G, Isabella C, Kroes H, Dempsey J, Gremmels H, Monroe G, et al. MKS1 regulates ciliary INPP5E levels in Joubert syndrome. J Med Genet. 2016;53:62-72 pubmed publisher
    ..Mutations in INPP5E also cause JS, so our findings in patient fibroblasts support the notion that loss of INPP5E function, due to either mutation or mislocalisation, is a key mechanism underlying JS, downstream of MKS1 and ARL13B. ..
  54. Dutta A, Khimji A, Liu S, Karamysheva Z, Fujita A, Kresge C, et al. PKCα regulates TMEM16A-mediated Cl⁻ secretion in human biliary cells. Am J Physiol Gastrointest Liver Physiol. 2016;310:G34-42 pubmed publisher
    ..Targeting this ATP-Ca(2+)-PKCα signaling pathway may represent a therapeutic strategy to increase biliary secretion and promote bile formation. ..
  55. Halleck M, Schlegel R, Williamson P. Reanalysis of ATP11B, a type IV P-type ATPase. J Biol Chem. 2002;277:9736-40 pubmed publisher
    ..The ATP11B gene thus may not encode a protein with a function radically different from that of other P-type ATPase transporters...
  56. Makielski J, Ye B, Valdivia C, Pagel M, Pu J, Tester D, et al. A ubiquitous splice variant and a common polymorphism affect heterologous expression of recombinant human SCN5A heart sodium channels. Circ Res. 2003;93:821-8 pubmed
    ..These results have implications for the choice of background sequence for experiments with heterologous expression systems, and possibly implications for electrophysiological function in vivo. ..
  57. Cho H, Verlinde C, Weiner A. Archaeal CCA-adding enzymes: central role of a highly conserved beta-turn motif in RNA polymerization without translocation. J Biol Chem. 2005;280:9555-66 pubmed publisher
    ..We also suggest that beta-turn mutants can affect nucleotide selection because the growing 3' end of tRNA must be properly positioned to serve as part of the ribonucleoprotein template that selects the incoming nucleotide...
  58. Zhang A, Liu X, Cogan J, Fuerst M, Polikandriotis J, Kelm R, et al. YB-1 coordinates vascular smooth muscle alpha-actin gene activation by transforming growth factor beta1 and thrombin during differentiation of human pulmonary myofibroblasts. Mol Biol Cell. 2005;16:4931-40 pubmed
    ..This loop may help restrict organ-destructive remodeling due to excessive myofibroblast differentiation. ..
  59. Nikolic D, Cholewa J, Gass C, Gong M, Post S. Class A scavenger receptor-mediated cell adhesion requires the sequential activation of Lyn and PI3-kinase. Am J Physiol Cell Physiol. 2007;292:C1450-8 pubmed
    ..Thus SR-A binding to modified protein activates signaling cascades that have distinct roles in regulating initial cell attachment and subsequent cell spreading. ..
  60. Bozulic L, Malik M, Powell D, Nanez A, Link A, Ramos K, et al. Plasma membrane Ca(2+) -ATPase associates with CLP36, alpha-actinin and actin in human platelets. Thromb Haemost. 2007;97:587-97 pubmed
    ..Thus, in addition to the reversible serine/threonine and tyrosine phosphorylation events previously described in human platelets, PMCA function may be regulated by interactions with anchoring and cytoskeletal proteins. ..
  61. White C, Lee J, Kambe T, Fritsche K, Petris M. A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity. J Biol Chem. 2009;284:33949-56 pubmed publisher
    ..Collectively, these data suggest that copper-transporting ATPases, CopA and ATP7A, in both bacteria and macrophage are unique determinants of bacteria survival and identify an unexpected role for copper at the host-pathogen interface. ..
  62. Celver J, Sharma M, Kovoor A. RGS9-2 mediates specific inhibition of agonist-induced internalization of D2-dopamine receptors. J Neurochem. 2010;114:739-49 pubmed publisher
  63. Lefort C, Wojciechowski K, Hocking D. N-cadherin cell-cell adhesion complexes are regulated by fibronectin matrix assembly. J Biol Chem. 2011;286:3149-60 pubmed publisher
  64. Yi K, Unruh J, Deng M, Slaughter B, Rubinstein B, Li R. Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes. Nat Cell Biol. 2011;13:1252-8 pubmed publisher
    ..Thus, the asymmetric MII spindle position is dynamically maintained as a result of balanced forces governed by the Arp2/3 complex. ..
  65. Khurana S, Chakraborty S, Lam M, Liu Y, Su Y, Zhao X, et al. Familial focal segmental glomerulosclerosis (FSGS)-linked ?-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors. J Biol Chem. 2012;287:12027-35 pubmed publisher
    ..Our data provide the first link between FSGS-linked ACTN4 mutants and transcriptional activation by nuclear receptor such as RAR? and peroxisome proliferator-activated receptor ?. ..
  66. Zhong D, Lefebre M, Kaur K, McDowell M, Gdowski C, Jo S, et al. The Salmonella type III secretion system inner rod protein PrgJ is partially folded. J Biol Chem. 2012;287:25303-11 pubmed publisher
    ..Likewise, CD and NMR data for the Shigella inner rod protein MxiI indicate this protein lacks a tertiary structure as well. Our results reveal that the monomeric forms of the T3SS inner rod proteins are partially folded. ..
  67. Dalbey R, Wang P, van Dijl J. Membrane proteases in the bacterial protein secretion and quality control pathway. Microbiol Mol Biol Rev. 2012;76:311-30 pubmed publisher
    ..This review highlights the different ways that bacterial membrane proteases degrade their substrates, with special emphasis on catalytic mechanisms and substrate delivery to the respective active sites. ..
  68. Di X, Han D, Wang Y, Chance M, Mu T. SAHA enhances Proteostasis of epilepsy-associated ?1(A322D)?2?2 GABA(A) receptors. Chem Biol. 2013;20:1456-68 pubmed publisher
    ..SAHA is a drug that enhances epilepsy-associated GABAA receptor proteostasis. ..
  69. Friedman M, Henderson J, Aukerman J, Clingan P. Effect of periodic alterations in shear on vascular macromolecular uptake. Biorheology. 2000;37:265-77 pubmed
    ..Albumin uptake increases with tau in a fashion that can be explained by an a priori model of the adaptive permeability response, with a time constant of about an hour. ..
  70. Schilling D, Pittelkow M, Kumar R. IEX-1, an immediate early gene, increases the rate of apoptosis in keratinocytes. Oncogene. 2001;20:7992-7 pubmed
    ..However, the rate of apoptosis increases in IEX-1 overexpressing HaCaT keratinocytes after cells are subjected to stress. ..
  71. Becker K, Hannun Y. Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D. J Biol Chem. 2004;279:28251-6 pubmed
    ..Taken together, these results define specific biochemical and cellular actions of PKCbetaII when compared with PKCbetaI. ..
  72. Ballew N, Liu Y, Barlowe C. A Rab requirement is not bypassed in SLY1-20 suppression. Mol Biol Cell. 2005;16:1839-49 pubmed
  73. Parihar M, Parihar A, Fujita M, Hashimoto M, Ghafourifar P. Mitochondrial association of alpha-synuclein causes oxidative stress. Cell Mol Life Sci. 2008;65:1272-84 pubmed publisher
    ..These findings suggest a pivotal role for mitochondria in oxidative stress and apoptosis induced by alpha-synuclein. ..
  74. Yang M, Hay J, Ruyechan W. Varicella-zoster virus IE62 protein utilizes the human mediator complex in promoter activation. J Virol. 2008;82:12154-63 pubmed publisher
    ..These studies suggest that Mediator is an essential component for efficient VZV gene expression. ..
  75. Wang Y, Zhang L, Picking W, Picking W, De Guzman R. Structural dissection of the extracellular moieties of the type III secretion apparatus. Mol Biosyst. 2008;4:1176-80 pubmed publisher
    ..In this highlight, the structure-function of TTSA needle and tip complex proteins are described and common themes discussed...
  76. Wu D, Asiedu M, Wei Q. Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC. Oncogene. 2009;28:2219-30 pubmed publisher
    ..Taken together, our results suggest that MyoGEF cooperates with NMIIA to regulate the polarity and invasion activity of breast cancer cells through activation of RhoA and RhoC. ..
  77. Smith K, Twal W, Soodavar F, Virella G, Lopes Virella M, Hammad S. Heat shock protein 70B' (HSP70B') expression and release in response to human oxidized low density lipoprotein immune complexes in macrophages. J Biol Chem. 2010;285:15985-93 pubmed publisher
    ..The data also implicate HSP70B' in key cellular functions, such as regulation of SK1 activity and release of IL-10, which influence macrophage activation and survival. ..
  78. Chu L, Silverstein R. CD36 ectodomain phosphorylation blocks thrombospondin-1 binding: structure-function relationships and regulation by protein kinase C. Arterioscler Thromb Vasc Biol. 2012;32:760-7 pubmed publisher
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