Experts and Doctors on protein subunits in France


Locale: France
Topic: protein subunits

Top Publications

  1. Le Goff G, Hamon A, Berg J, Amichot M. Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA receptor subunit. J Neurochem. 2005;92:1295-305 pubmed publisher
    ..In conclusion, the present study emphasizes new aspects of the pharmacological alterations induced by the Rdl mutation and shows that resistance to GABA receptor-directed insecticides may implicate a mutation distinct from Rdl...
  2. Bottero V, Rossi F, Samson M, Mari M, Hofman P, Peyron J. Ikappa b-alpha, the NF-kappa B inhibitory subunit, interacts with ANT, the mitochondrial ATP/ADP translocator. J Biol Chem. 2001;276:21317-24 pubmed
    ..NF-kappaB appeared to be released from mitochondria upon the induction of apoptosis by engagement of the Fas receptor. These data suggest that the mitochondrial IkappaB-alpha.NF-kappaB pool participates in the regulation of apoptosis. ..
  3. Jiang R, Martz A, Gonin S, Taly A, de Carvalho L, Grutter T. A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptor. J Biol Chem. 2010;285:15805-15 pubmed publisher
  4. Mulle C, Sailer A, Swanson G, Brana C, O GORMAN S, Bettler B, et al. Subunit composition of kainate receptors in hippocampal interneurons. Neuron. 2000;28:475-84 pubmed
    ..The existence of two separate populations of KARs in hippocampal interneurons adds to the complexity of KAR localization and function. ..
  5. Senger B, Lafontaine D, Graindorge J, Gadal O, Camasses A, Sanni A, et al. The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis. Mol Cell. 2001;8:1363-73 pubmed
  6. Pinheiro P, Perrais D, Coussen F, Barhanin J, Bettler B, Mann J, et al. GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proc Natl Acad Sci U S A. 2007;104:12181-6 pubmed
  7. Gaignard P, Menezes M, Schiff M, Bayot A, Rak M, Ogier de Baulny H, et al. Mutations in CYC1, encoding cytochrome c1 subunit of respiratory chain complex III, cause insulin-responsive hyperglycemia. Am J Hum Genet. 2013;93:384-9 pubmed publisher
  8. Belbeoc h S, Massoulié J, Bon S. The C-terminal T peptide of acetylcholinesterase enhances degradation of unassembled active subunits through the ERAD pathway. EMBO J. 2003;22:3536-45 pubmed
    ..This system appears particularly well suited to analyze the mechanisms which determine the degradation of correctly folded multidomain proteins in the ER. ..
  9. Bourne Y, Roig Zamboni V, Barre A, Peumans W, Astoul C, Van Damme E, et al. The crystal structure of the Calystegia sepium agglutinin reveals a novel quaternary arrangement of lectin subunits with a beta-prism fold. J Biol Chem. 2004;279:527-33 pubmed
    ..The present structure exemplifies the adaptability of the beta-prism building block in the evolution of plant lectins and highlights the biological role of these quaternary structures for carbohydrate recognition...

More Information

Publications224 found, 100 shown here

  1. Tarendeau F, Boudet J, Guilligay D, Mas P, Bougault C, Boulo S, et al. Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat Struct Mol Biol. 2007;14:229-33 pubmed
    ..The domain contains three surface residues implicated in adaptation from avian to mammalian hosts. One of these tethers the NLS-containing peptide to the core of the domain in the unbound state. ..
  2. de Lacroix de Lavalette A, Finazzi G, Zito F. b6f-Associated chlorophyll: structural and dynamic contribution to the different cytochrome functions. Biochemistry. 2008;47:5259-65 pubmed publisher
    ..Moreover, the chlorophyll and its binding pocket may also be implicated in the regulation of photosynthetic state transitions, a function that is specific to cyt b6f complexes. ..
  3. Peyronnet R, Sharif Naeini R, Folgering J, Arhatte M, Jodar M, El Boustany C, et al. Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels. Cell Rep. 2012;1:241-50 pubmed publisher
    ..We propose that this mechanism is at play in other important pathologies associated with apoptosis and in which pressure or flow stimulation is altered, including heart failure or atherosclerosis. ..
  4. Saint Dizier M, Sandra O, Ployart S, Chebrout M, Constant F. Expression of nuclear progesterone receptor and progesterone receptor membrane components 1 and 2 in the oviduct of cyclic and pregnant cows during the post-ovulation period. Reprod Biol Endocrinol. 2012;10:76 pubmed
    ..Our findings suggest that P4 regulates the functions of the bovine oviduct in a region-specific manner and through both classical and non classical pathways during the post-ovulation period. ..
  5. Choquet Y, Wostrikoff K, Rimbault B, Zito F, Girard Bascou J, Drapier D, et al. Assembly-controlled regulation of chloroplast gene translation. Biochem Soc Trans. 2001;29:421-6 pubmed
    ..We discuss the possible implications regarding the mechanism of the CES process for cytochrome f expression. We have studied the possible generalization of this mechanism to other CES proteins. ..
  6. Doublet P, Grangeasse C, Obadia B, Vaganay E, Cozzone A. Structural organization of the protein-tyrosine autokinase Wzc within Escherichia coli cells. J Biol Chem. 2002;277:37339-48 pubmed
    ..These data, connected with the phosphorylation mechanism of Wzc, may be of biological significance in the regulatory role played by this kinase in polysaccharide synthesis. ..
  7. Chemin J, Nargeot J, Lory P. Neuronal T-type alpha 1H calcium channels induce neuritogenesis and expression of high-voltage-activated calcium channels in the NG108-15 cell line. J Neurosci. 2002;22:6856-62 pubmed
  8. Gissot L, Polge C, Bouly J, Lemaitre T, Kreis M, Thomas M. AKINbeta3, a plant specific SnRK1 protein, is lacking domains present in yeast and mammals non-catalytic beta-subunits. Plant Mol Biol. 2004;56:747-59 pubmed
    ..These data suggest the existence of novel SnRK1 complexes including AKINbeta3-type subunits, involved in several functions among which some could be plant specific. ..
  9. Schmitt E, Panvert M, Blanquet S, Mechulam Y. Structural basis for tRNA-dependent amidotransferase function. Structure. 2005;13:1421-33 pubmed publisher
    ..Comparison of GatD and L-asparaginase structures shows how the motion of a beta hairpin region containing a crucial catalytic threonine may control the overall reaction cycle of GatDE...
  10. Tawar R, Duquerroy S, Vonrhein C, Varela P, Damier Piolle L, Castagné N, et al. Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science. 2009;326:1279-83 pubmed publisher
    ..Furthermore, the nucleoprotein structure highlights possible key sites for drug targeting. ..
  11. B ven L, Charenton C, Dautant A, Bouyssou G, Labroussaa F, Sk llermo A, et al. Specific evolution of F1-like ATPases in mycoplasmas. PLoS ONE. 2012;7:e38793 pubmed publisher
    ..We propose a model, in which the F(1)-like structure is associated with a hypothetical X(0) sector located in the membrane of mycoplasma cells...
  12. Couloigner V, Fay M, Djelidi S, Farman N, Escoubet B, Runembert I, et al. Location and function of the epithelial Na channel in the cochlea. Am J Physiol Renal Physiol. 2001;280:F214-22 pubmed
    ..In conclusion, ENaC subunits are expressed in epithelial and nonepithelial cochlear structures. One of its functions is probably to maintain the low concentration of Na in endolymph...
  13. Boué Grabot E, Toulme E, Emerit M, Garret M. Subunit-specific coupling between gamma-aminobutyric acid type A and P2X2 receptor channels. J Biol Chem. 2004;279:52517-25 pubmed
    ..This gamma subunit-dependent cross-talk may contribute to the regulation of synaptic activity. ..
  14. Mousson L, Dauga C, Garrigues T, Schaffner F, Vazeille M, Failloux A. Phylogeography of Aedes (Stegomyia) aegypti (L.) and Aedes (Stegomyia) albopictus (Skuse) (Diptera: Culicidae) based on mitochondrial DNA variations. Genet Res. 2005;86:1-11 pubmed
    ..This suggests that African populations of A. aegypti introduced during the slave trade have persisted in Boa Vista, resisting eradication campaigns. ..
  15. Benamer N, Moha Ou Maati H, Demolombe S, Cantereau A, Delwail A, Bois P, et al. Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts. J Mol Cell Cardiol. 2009;46:508-17 pubmed publisher
    ..1 channels represent a significant potassium conductance in ventricular fibroblasts which may be activated in physio-pathological conditions and which may impact on fibroblast proliferation and function...
  16. Portal M. MicroRNA-27a regulates basal transcription by targeting the p44 subunit of general transcription factor IIH. Proc Natl Acad Sci U S A. 2011;108:8686-91 pubmed publisher
    ..This work is unique in providing a demonstration of global transcriptional regulation through the action of a single miRNA. ..
  17. Lamotte D Incamps B, Ascher P. Subunit composition and kinetics of the Renshaw cell heteromeric nicotinic receptors. Biochem Pharmacol. 2013;86:1114-21 pubmed publisher
    ..The results can be interpreted by assuming that the nAChRs exist in two stoichiometries, subsynaptic "low sensitivity" nAChRs and extrasynaptic "high sensitivity" nAChRs activated by spillover. ..
  18. Rocher A, Gubellini P, Merienne N, Boussicault L, Petit F, Gipchtein P, et al. Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease. Neurobiol Dis. 2016;86:131-9 pubmed publisher
    ..These homeostatic mechanisms may compensate for the substantial loss of synaptic inputs and thus alleviate the deleterious effects of mHTT expression on the activity of MSNs and also possibly on the motor phenotype in aged BACHD. ..
  19. Warfield L, Ramachandran S, Baptista T, Devys D, Tora L, Hahn S. Transcription of Nearly All Yeast RNA Polymerase II-Transcribed Genes Is Dependent on Transcription Factor TFIID. Mol Cell. 2017;68:118-129.e5 pubmed publisher
    ..Our work indicates that TFIID participates in expression of nearly all yeast mRNAs and that differences in regulation between these two gene categories is due to other properties. ..
  20. Krebs A, Demmers J, Karmodiya K, Chang N, Chang A, Tora L. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. EMBO Rep. 2010;11:541-7 pubmed publisher
    ..Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes. ..
  21. Frontini M, Soutoglou E, Argentini M, Bole Feysot C, Jost B, Scheer E, et al. TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. Mol Cell Biol. 2005;25:4638-49 pubmed
    ..Taken together, these data demonstrate that TAF9 and TAF9b share some of their functions, but more importantly, they have distinct roles in the transcriptional regulatory process. ..
  22. Benchoua A, Trioulier Y, Diguet E, Malgorn C, Gaillard M, Dufour N, et al. Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II. Hum Mol Genet. 2008;17:1446-56 pubmed publisher
    ..This novel pathway links dopamine signaling and regulation of mCII activity and could play a key role in oxidative energy metabolism and explain the vulnerability of the striatum in neurodegenerative diseases. ..
  23. Esnault C, Ghavi Helm Y, Brun S, Soutourina J, Van Berkum N, Boschiero C, et al. Mediator-dependent recruitment of TFIIH modules in preinitiation complex. Mol Cell. 2008;31:337-46 pubmed publisher
    ..We conclude that the Mediator head module plays a critical role in TFIIH and TFIIE recruitment to the PIC. We identify steps in PIC formation that suggest a branched assembly pathway. ..
  24. Renodon Cornière A, Takizawa Y, Conilleau S, Tran V, Iwai S, Kurumizaka H, et al. Structural analysis of the human Rad51 protein-DNA complex filament by tryptophan fluorescence scanning analysis: transmission of allosteric effects between ATP binding and DNA binding. J Mol Biol. 2008;383:575-87 pubmed publisher
    ..This information will be useful to build a molecular model of the Rad51-DNA complex and to understand the mechanism of activation of Rad51 by ATP and that of the Rad51-promoted strand exchange reaction. ..
  25. Neveu C, Charvet C, Fauvin A, Cortet J, Beech R, Cabaret J. Genetic diversity of levamisole receptor subunits in parasitic nematode species and abbreviated transcripts associated with resistance. Pharmacogenet Genomics. 2010;20:414-25 pubmed publisher
    ..This study contributes significantly to a better understanding of LEV receptor constitution in parasitic nematodes and highlights the putative role of aberrant mRNA encoding L-AChR subunits in LEV resistance. ..
  26. Gouin E, Adib Conquy M, Balestrino D, Nahori M, Villiers V, Colland F, et al. The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}. Proc Natl Acad Sci U S A. 2010;107:17333-8 pubmed publisher
    ..Together, these results demonstrate that InlC, by interacting with IKKα, dampens the host innate response induced by Listeria during the infection process. ..
  27. Dupuis J, Gauthier M, Raymond Delpech V. Expression patterns of nicotinic subunits ?2, ?7, ?8, and ?1 affect the kinetics and pharmacology of ACh-induced currents in adult bee olfactory neuropiles. J Neurophysiol. 2011;106:1604-13 pubmed publisher
  28. Laloum T, De Mita S, Gamas P, Baudin M, Niebel A. CCAAT-box binding transcription factors in plants: Y so many?. Trends Plant Sci. 2013;18:157-66 pubmed publisher
    ..The first group has more general expression patterns and/or functions whereas the second group has acquired more specific expression patterns and/or functions and could play key roles in specific pathways. ..
  29. Larousserie F, Bardel E, Coulomb L Hermine A, Canioni D, Brousse N, Kastelein R, et al. Variable expression of Epstein-Barr virus-induced gene 3 during normal B-cell differentiation and among B-cell lymphomas. J Pathol. 2006;209:360-8 pubmed
    ..No or rare p28 expression was detected in normal or tumour B cells. This constitutive expression of EBI3 by neoplastic B cells may be involved in lymphomagenesis, and may be a useful marker for lymphoma diagnosis. ..
  30. Zhu S, Riou M, Yao C, Carvalho S, Rodriguez P, Bensaude O, et al. Genetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces. Proc Natl Acad Sci U S A. 2014;111:6081-6 pubmed publisher
    ..It also paves the way for engineering light-sensitive ligand-gated ion channels with subtype specificity through the genetic code expansion. ..
  31. Petit J, Briat J, Lobreaux S. Structure and differential expression of the four members of the Arabidopsis thaliana ferritin gene family. Biochem J. 2001;359:575-82 pubmed
  32. Franzetti B, Schoehn G, Hernandez J, Jaquinod M, Ruigrok R, Zaccai G. Tetrahedral aminopeptidase: a novel large protease complex from archaea. EMBO J. 2002;21:2132-8 pubmed publisher
    ..This architecture is different from that of all the proteolytic complexes described to date that are made up by rings or barrels with a single central channel and only two openings...
  33. Girard C, Tinel N, Terrenoire C, Romey G, Lazdunski M, Borsotto M. p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1. EMBO J. 2002;21:4439-48 pubmed
    ..p11 association with the TASK-1 channel masks an endoplasmic reticulum retention signal identified as Lys-Arg-Arg that precedes the Ser-Ser-Val sequence. ..
  34. Mazza C, Segref A, Mattaj I, Cusack S. Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. EMBO J. 2002;21:5548-57 pubmed
    ..Implications for the transfer of capped mRNAs to eIF4E, required for translation initiation, are discussed. ..
  35. Pointud J, Mengus G, Brancorsini S, Monaco L, Parvinen M, Sassone Corsi P, et al. The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. J Cell Sci. 2003;116:1847-58 pubmed
  36. Mansuy V, Boireau W, Fraichard A, Schlick J, Jouvenot M, Delage Mourroux R. GEC1, a protein related to GABARAP, interacts with tubulin and GABA(A) receptor. Biochem Biophys Res Commun. 2004;325:639-48 pubmed
    ..GEC1-GFP was distributed over the cytoplasm in perinuclear vesicles with a scattered pattern. Overall, our data show that GEC1 could be a new member of the GABARAP family involved in the transport of GABA(A) receptor. ..
  37. Muller E, Triller A, Legendre P. Glycine receptors and GABA receptor alpha 1 and gamma 2 subunits during the development of mouse hypoglossal nucleus. Eur J Neurosci. 2004;20:3286-300 pubmed
    ..A developmental sequence of the postsynaptic events is proposed in which diffuse extrasynaptic GABA(A)Rs accumulate at inhibitory synapses to form postsynaptic clusters, most of them being colocalized with GlyR clusters in the adult. ..
  38. Massenet C, Chenavas S, Cohen Addad C, Dagher M, Brandolin G, Pebay Peyroula E, et al. Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains. J Biol Chem. 2005;280:13752-61 pubmed
    ..Other mechanisms than a phosphorylation induced switch between the two SH3 must therefore take place for NADPH oxidase activation cascade to start. ..
  39. Grimaldi S, Lanciano P, Bertrand P, Blasco F, Guigliarelli B. Evidence for an EPR-detectable semiquinone intermediate stabilized in the membrane-bound subunit NarI of nitrate reductase A (NarGHI) from Escherichia coli. Biochemistry. 2005;44:1300-8 pubmed
    ..These results are discussed with regard to the location and the potential function of quinones in the enzyme. ..
  40. Johannes L, Decaudin D. Protein toxins: intracellular trafficking for targeted therapy. Gene Ther. 2005;12:1360-8 pubmed
    ..The cell biological basis of these novel types of toxin-based therapeutics will be discussed, and we will summarize ongoing preclinical and clinical testing. ..
  41. Benga W, Grandemange S, Shpakovski G, Shematorova E, Kedinger C, Vigneron M. Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II. Nucleic Acids Res. 2005;33:3582-90 pubmed
    ..These data indicate that the heterodimerization interfaces have been modified during the course of evolution to allow a recent diversification of the human RPB11 subunits that remains compatible with heterodimerization with RPB3. ..
  42. Mylona A, Acker J, Fernández Tornero C, Sentenac A, Müller C. Expression, proteolytic analysis, reconstitution, and crystallization of the tau60/tau91 subcomplex of yeast TFIIIC. Protein Expr Purif. 2006;45:255-61 pubmed
    ..Crystals diffracting beyond 3.2 A were obtained from a complex formed by full-length tau60 and the N-terminally truncated form of tau91 lacking this extension. ..
  43. Vitorino M, Coin F, Zlobinskaya O, Atkinson R, Moras D, Egly J, et al. Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy. J Mol Biol. 2007;368:473-80 pubmed
    ..Point mutations found in TTD-A patients are discussed on the basis of the present structure. ..
  44. Coin F, Oksenych V, Egly J. Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol Cell. 2007;26:245-56 pubmed
    ..Our results suggest a mechanism in which the helicase activity of XPB is not used for the opening and repair of damaged DNA, which is instead only driven by its ATPase activity, in combination with the helicase activity of XPD. ..
  45. Guittet O, Tebbi A, Cottet M, Vésin F, Lepoivre M. Upregulation of the p53R2 ribonucleotide reductase subunit by nitric oxide. Nitric Oxide. 2008;19:84-94 pubmed publisher
    ..Knocking down p53R2 in p53-wt cells dramatically enhances NO-induced DNA damages, indicating a protective function of the p53R2 ribonucleotide reductase subunit in prevention or repair of NO-mediated genotoxic injury. ..
  46. Van Rechem C, Boulay G, Leprince D. HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A. Biochem Biophys Res Commun. 2009;385:586-90 pubmed publisher
    ..Finally, sequential chromatin immunoprecipitation (ChIP-reChIP) experiments demonstrated that HIC1 represses E2F1 through the recruitment of anti-proliferative SWI/SNF complexes containing ARID1A. ..
  47. Werner M, Thuriaux P, Soutourina J. Structure-function analysis of RNA polymerases I and III. Curr Opin Struct Biol. 2009;19:740-5 pubmed publisher
    ..Unexpectedly, even though Pol I and III, but not Pol II, have an intrinsic RNA cleavage activity, it was found that TFIIS Pol II cleavage stimulation factor also played a general role in Pol III transcription. ..
  48. Vinchon S, Moreau S, Drezen J, Prevost G, Cherqui A. Molecular and biochemical analysis of an aspartylglucosaminidase from the venom of the parasitoid wasp Asobara tabida (Hymenoptera: Braconidae). Insect Biochem Mol Biol. 2010;40:38-48 pubmed publisher
    ..The study of this enzyme may allow a better understanding of the functional evolution of venom enzymes in hymenopteran parasitoids...
  49. Tercé Laforgue T, Bedu M, Dargel Grafin C, Dubois F, Gibon Y, Restivo F, et al. Resolving the role of plant glutamate dehydrogenase: II. Physiological characterization of plants overexpressing the two enzyme subunits individually or simultaneously. Plant Cell Physiol. 2013;54:1635-47 pubmed publisher
  50. Mazza C, Ohno M, Segref A, Mattaj I, Cusack S. Crystal structure of the human nuclear cap binding complex. Mol Cell. 2001;8:383-96 pubmed
    ..Site-directed mutagenesis revealed 4 residues of CBP20 which are critical for cap binding. A model for cap binding is proposed based on these results and the known mode of binding of RNA to RNP domains. ..
  51. Diochot S, Baron A, Salinas M, Douguet D, Scarzello S, Dabert Gay A, et al. Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature. 2012;490:552-5 pubmed publisher
    ..These findings identify new potential therapeutic targets for pain and introduce natural peptides that block them to produce a potent analgesia...
  52. Ferreira C, Santambrogio P, Martin M, Andrieu V, Feldmann G, Henin D, et al. H ferritin knockout mice: a model of hyperferritinemia in the absence of iron overload. Blood. 2001;98:525-32 pubmed
    ..Blood. 2001;98:525-532) ..
  53. Newman Tancredi A, Cussac D, Marini L, Millan M. Antibody capture assay reveals bell-shaped concentration-response isotherms for h5-HT(1A) receptor-mediated Galpha(i3) activation: conformational selection by high-efficacy agonists, and relationship to trafficking of receptor signaling. Mol Pharmacol. 2002;62:590-601 pubmed
    ..In contrast, partial agonists favor h5-HT(1A) receptor signaling to Galpha(i3) over a wide concentration range, whereas inverse agonists inhibit constitutive Galpha(i3) activation. ..
  54. Minoletti C, Santolini J, Haraux F, Pothier J, Andre F. Rebuilt 3D structure of the chloroplast f1 ATPase-tentoxin complex. Proteins. 2002;49:302-20 pubmed
    ..These results suggest a mechanism of CF1 inhibition by one molecule of tentoxin, by the impossibility of the alpha/beta interface bearing tentoxin to pass through the ATP-loaded state. ..
  55. Legagneux V, Cubizolles F, Watrin E. Multiple roles of Condensins: a complex story. Biol Cell. 2004;96:201-13 pubmed
    ..However, the exact contribution of each subunit remains largely elusive as well as the functional interplay between Condensin I and Condensin II. ..
  56. Lefebvre Legendre L, Salin B, Schaeffer J, Brèthes D, Dautant A, Ackerman S, et al. Failure to assemble the alpha 3 beta 3 subcomplex of the ATP synthase leads to accumulation of the alpha and beta subunits within inclusion bodies and the loss of mitochondrial cristae in Saccharomyces cerevisiae. J Biol Chem. 2005;280:18386-92 pubmed
    ..These observations are in accord with other studies in the literature that have pointed to a central role for the ATP synthase in biogenesis of the mitochondrial inner membrane. ..
  57. Vassias I, Lecolle S, Vidal P, de Waele C. Modulation of GABA receptor subunits in rat facial motoneurons after axotomy. Brain Res Mol Brain Res. 2005;135:260-75 pubmed
    ..The loss of GABA(A)alpha1 subunit was most probably induced by both the loss of trophic factors transported from the periphery and a positive injury signal. It also seems to be dependent on activity disruption. ..
  58. Scheuring S, Sturgis J. Chromatic adaptation of photosynthetic membranes. Science. 2005;309:484-7 pubmed
    ..Such structural adaptation ensures efficient photon capture under low-light conditions and prevents photodamage under high-light conditions...
  59. Barat Houari M, Hilliou F, Jousset F, Sofer L, Deleury E, Rocher J, et al. Gene expression profiling of Spodoptera frugiperda hemocytes and fat body using cDNA microarray reveals polydnavirus-associated variations in lepidopteran host genes transcript levels. BMC Genomics. 2006;7:160 pubmed
    ..In this study, we analyzed transcriptional variations in the two main effectors of the insect immune response, the hemocytes and the fat body, after injection of filter-purified HdIV...
  60. Taly A, Corringer P, Grutter T, Prado de Carvalho L, Karplus M, Changeux J. Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors. Proc Natl Acad Sci U S A. 2006;103:16965-70 pubmed
    ..The present analysis, thus, supports the quaternary twist model of the nAChR allosteric transition and provides a qualitative interpretation of the effect of the mutations responsible for several receptor pathologies. ..
  61. Lemmens L, Urbach S, Prudent R, Cochet C, Baldacci G, Hughes P. Phosphorylation of the C subunit (p66) of human DNA polymerase delta. Biochem Biophys Res Commun. 2008;367:264-70 pubmed
    ..Taken together, the results provide evidence that concurrent phosphorylation events in p66 may positively and negatively regulate its activity and interactions with other components of the replisome during the cell cycle. ..
  62. Le Feuvre A, Dantas Barbosa C, Baldin V, Coux O. High yield bacterial expression and purification of active recombinant PA28alphabeta complex. Protein Expr Purif. 2009;64:219-24 pubmed publisher
    ..coli. Co-expression of the two proteins allows efficient formation of active PA28alphabeta complexes, that remain soluble and can be easily purified by regular chromatographic procedures. ..
  63. Gallois J, Guyon Debast A, Lecureuil A, Vezon D, Carpentier V, Bonhomme S, et al. The Arabidopsis proteasome RPT5 subunits are essential for gametophyte development and show accession-dependent redundancy. Plant Cell. 2009;21:442-59 pubmed publisher
    ..In conclusion, RPT5 subunits are not only essential for both male and female gametophyte development but also display accession-dependent redundancy and are crucial in cell cycle progression. ..
  64. Crozet P, Jammes F, Valot B, Ambard Bretteville F, Nessler S, Hodges M, et al. Cross-phosphorylation between Arabidopsis thaliana sucrose nonfermenting 1-related protein kinase 1 (AtSnRK1) and its activating kinase (AtSnAK) determines their catalytic activities. J Biol Chem. 2010;285:12071-7 pubmed publisher
    ..A mechanism is proposed to explain the observed changes in the enzymatic properties of each kinase triggered by these phosphorylation events. ..
  65. Obiang P, Macrez R, Jullienne A, Bertrand T, Lesept F, Ali C, et al. GluN2D subunit-containing NMDA receptors control tissue plasminogen activator-mediated spatial memory. J Neurosci. 2012;32:12726-34 pubmed publisher
    ..Altogether, our data provide the first evidence that tPA influences spatial memory through its preferential interaction with GluN2D subunit-containing NMDARs. ..
  66. Moragues N, Ciofi P, Lafon P, Tramu G, Garret M. GABAA receptor epsilon subunit expression in identified peptidergic neurons of the rat hypothalamus. Brain Res. 2003;967:285-9 pubmed
    ..Our results suggest that novel GABA(A) receptor subtypes comprising epsilon-subunit are important for metabolic and neuroendocrine functions. ..
  67. Bourges I, Ramus C, Mousson de Camaret B, Beugnot R, Remacle C, Cardol P, et al. Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin. Biochem J. 2004;383:491-9 pubmed
    ..This is the first description of prohibitin interaction with complex I subunits and suggests that this protein might play a role in the assembly or degradation of mitochondrial complex I. ..
  68. Stasia M, Bordigoni P, Martel C, Morel F. A novel and unusual case of chronic granulomatous disease in a child with a homozygous 36-bp deletion in the CYBA gene (A22(0)) leading to the activation of a cryptic splice site in intron 4. Hum Genet. 2002;110:444-50 pubmed
    ..The splicing mRNA error is attributable to the loss of the ag acceptor site of intron 4 and the utilization of a cryptic splice site with an ag sequence at position 355-356 of intron 4. ..
  69. Groussin L, Kirschner L, Vincent Dejean C, Perlemoine K, Jullian E, Delemer B, et al. Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiol. Am J Hum Genet. 2002;71:1433-42 pubmed
  70. Debure L, Vayssiere J, Rincheval V, Loison F, Le Drean Y, Michel D. Intracellular clusterin causes juxtanuclear aggregate formation and mitochondrial alteration. J Cell Sci. 2003;116:3109-21 pubmed
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    ..Together, our results show that TAF4 is an important regulator of keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity. ..
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    ..The whole set of data provides evidence that AtKC1 is a conditionally-targeted Kv subunit, which probably downregulates the physiological activity of other Kv channel subunits in Arabidopsis. ..
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    ..Lastly, AtKC1 disruption appeared to reduce plant biomass production, showing that AtKC1-mediated channel activity regulation is required for normal plant growth. ..
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    ..Thus, our study demonstrates that in mammals, CK2beta is essential for viability at the cellular level, possibly because it acquired new functions during evolution. ..
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    ..Finally, we report intriguing differences in APC2 protein subcellular localization compared with that in other systems. Our observations support a conserved function of the APC/C in plants but a different mode of regulation. ..