Experts and Doctors on protein subunits in Argentina


Locale: Argentina
Topic: protein subunits

Top Publications

  1. Rinaldi J, Wu J, Yang J, Ralston C, Sankaran B, Moreno S, et al. Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling. Structure. 2010;18:1471-82 pubmed publisher
    ..Phylogenetic analysis shows that structural differences in Bcy1 are shared by fungi of the subphylum Saccharomycotina. ..
  2. Elgoyhen A, Katz E, Fuchs P. The nicotinic receptor of cochlear hair cells: a possible pharmacotherapeutic target?. Biochem Pharmacol. 2009;78:712-9 pubmed publisher
    ..The potential use of alpha9alpha10 selective drugs in conditions such as noise-induced hearing loss, tinnitus and auditory processing disorders is discussed. ..
  3. Labombarda F, Coronel M, Villar M, Nicola A, González S. Neuropathic pain and temporal expression of preprodynorphin, protein kinase C and N-methyl-D-aspartate receptor subunits after spinal cord injury. Neurosci Lett. 2008;447:115-9 pubmed publisher
    ..The present study provides further evidence that these molecules are involved in the development/maintenance of central neuropathic pain and thus could be the target of therapeutic approaches. ..
  4. Plazas P, Savino J, Kracun S, Gómez Casati M, Katz E, Parsons C, et al. Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-D-aspartate receptors. Eur J Pharmacol. 2007;566:11-9 pubmed
  5. Craig P, Berguer P, Ainciart N, Zylberman V, Thomas M, Martinez Tosar L, et al. Multiple display of a protein domain on a bacterial polymeric scaffold. Proteins. 2005;61:1089-100 pubmed
    ..Our results underscore the BLS display strategy as a powerful tool for biotechnological and therapeutic applications. ..
  6. Fernández Murray P, Pardo P, Zelada A, Passeron S. In vivo and in vitro phosphorylation of Candida albicans 20S proteasome. Arch Biochem Biophys. 2002;404:116-25 pubmed
    ..Our demonstration of phosphorylation of C. albicans proteasome suggests that phosphorylation might be a general mechanism of regulation of proteasome activity. ..
  7. Ocampo J, McCormack B, Navarro E, Moreno S, Garre V, Rossi S. Protein kinase A regulatory subunit isoforms regulate growth and differentiation in Mucor circinelloides: essential role of PKAR4. Eukaryot Cell. 2012;11:989-1002 pubmed publisher
    ..The results indicate that each R isoform has a different role in M. circinelloides physiology, controlling the dimorphism and contributing to the specificity of cyclic AMP (cAMP)-PKA pathway. ..
  8. Plazas P, De Rosa M, Gómez Casati M, Verbitsky M, Weisstaub N, Katz E, et al. Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptor. Br J Pharmacol. 2005;145:963-74 pubmed
    ..These differences might be originated from slight differential intramolecular rearrangements during gating for the different receptors and might lead each nAChR to be in tune with their physiological roles. ..
  9. Gentili C, Morelli S, Russo de Boland A. Involvement of PI3-kinase and its association with c-Src in PTH-stimulated rat enterocytes. J Cell Biochem. 2002;86:773-83 pubmed

More Information


  1. Ferroni F, Guerrero S, Rizzi A, Brondino C. Overexpression, purification, and biochemical and spectroscopic characterization of copper-containing nitrite reductase from Sinorhizobium meliloti 2011. Study of the interaction of the catalytic copper center with nitrite and NO. J Inorg Biochem. 2012;114:8-14 pubmed publisher
    ..EPR characterization of the copper species obtained upon interaction of SmNir with nitrite, and catalytically-generated and exogenous NO reveals the formation of a Cu-NO EPR active species not detected before in closely related Nirs. ..
  2. Tudisca V, Simpson C, Castelli L, Lui J, Hoyle N, Moreno S, et al. PKA isoforms coordinate mRNA fate during nutrient starvation. J Cell Sci. 2012;125:5221-32 pubmed publisher
    ..Taken together, our data suggest that the PKA pathway coordinates multiple stages in the fate of mRNAs in association with nutritional environment and growth status of the cell. ..
  3. Baez M, Oberholzer M, Cercato M, Snitcofsky M, Aguirre A, Jerusalinsky D. NMDA receptor subunits in the adult rat hippocampus undergo similar changes after 5 minutes in an open field and after LTP induction. PLoS ONE. 2013;8:e55244 pubmed publisher
  4. Lipovsek M, Im G, Franchini L, Pisciottano F, Katz E, Fuchs P, et al. Phylogenetic differences in calcium permeability of the auditory hair cell cholinergic nicotinic receptor. Proc Natl Acad Sci U S A. 2012;109:4308-13 pubmed publisher
    ..In addition, they suggest that high Ca(2+) permeability of the ?9?10 cholinergic nicotinic receptor might have evolved together with other features that have given the mammalian ear an expanded high-frequency sensitivity...
  5. Weisstaub N, Vetter D, Elgoyhen A, Katz E. The alpha9alpha10 nicotinic acetylcholine receptor is permeable to and is modulated by divalent cations. Hear Res. 2002;167:122-35 pubmed
    ..8 mM Ca(2+) (14.3 microM), suggesting that potentiation by Ca(2+) involves changes in the apparent affinity of the alpha 9 alpha 10 receptor for ACh. ..
  6. Molinas M, De Candia A, Szajnman S, Rodriguez J, Marti M, Pereira M, et al. Electron transfer dynamics of Rhodothermus marinus caa3 cytochrome c domains on biomimetic films. Phys Chem Chem Phys. 2011;13:18088-98 pubmed publisher
    ..The intramolecular electron transfer pathway in integral subunit II from Cyt-D to the Cu(A) redox center most likely involves the iron ligand histidine 20 as an electron exit point in Cyt-D...
  7. Ituarte S, Dreon M, Pasquevich M, Fernández P, Heras H. Carbohydrates and glycoforms of the major egg perivitellins from Pomacea apple snails (Architaenioglossa: Ampullariidae). Comp Biochem Physiol B Biochem Mol Biol. 2010;157:66-72 pubmed publisher
    ..This is the first report of these structures in gastropods other than heterobranchs...
  8. Barraza C, Solari C, Marcovich I, Kershaw C, Galello F, Rossi S, et al. The role of PKA in the translational response to heat stress in Saccharomyces cerevisiae. PLoS ONE. 2017;12:e0185416 pubmed publisher
  9. Bentancor L, Bilen M, Brando R, Ramos M, Ferreira L, Ghiringhelli P, et al. A DNA vaccine encoding the enterohemorragic Escherichia coli Shiga-like toxin 2 A2 and B subunits confers protective immunity to Shiga toxin challenge in the murine model. Clin Vaccine Immunol. 2009;16:712-8 pubmed publisher
  10. Cabilla J, Ronchetti S, Nudler S, Miler E, Quinteros F, Duvilanski B. Nitric oxide sensitive-guanylyl cyclase subunit expression changes during estrous cycle in anterior pituitary glands. Am J Physiol Endocrinol Metab. 2009;296:E731-7 pubmed publisher
    ..These findings show that E2 physiologically regulates sGC expression and highlight a novel mechanism by which E2 downregulates sGC activity in rat anterior pituitary gland. ..
  11. de Plazas S, Rapacioli M, Rodriguez Gil D, Vacotto M, Flores V. Acute hypoxia differentially affects the gamma-aminobutyric acid type A receptor alpha(1), alpha(2), beta(2), and gamma(2) subunit mRNA levels in the developing chick optic tectum: stage-dependent sensitivity. J Neurosci Res. 2007;85:3135-44 pubmed
  12. Katz E, Elgoyhen A, Gómez Casati M, Knipper M, Vetter D, Fuchs P, et al. Developmental regulation of nicotinic synapses on cochlear inner hair cells. J Neurosci. 2004;24:7814-20 pubmed
    ..Furthermore, this developmental knock-out of alpha10, but not alpha9, supports the hypothesis that functional nicotinic acetylcholine receptors in hair cells are heteromers containing both these subunits. ..
  13. Parisi G, Fornasari M, Echave J. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. FEBS Lett. 2004;562:1-4 pubmed
    ..The structural models we obtained could contribute to the understanding of the complex interactions that dynactins are able to establish with cargo particles, microtubules or other dynactin subunits. ..
  14. Hockl P, Sorianello E, Chamson Reig A, Ballerini G, Campo S, Groome N, et al. Gonadotropins and inhibins along the development of a luteinized rat ovarian tumor. Mol Cell Endocrinol. 2003;203:137-46 pubmed
  15. Tudisca V, Recouvreux V, Moreno S, Boy Marcotte E, Jacquet M, Portela P. Differential localization to cytoplasm, nucleus or P-bodies of yeast PKA subunits under different growth conditions. Eur J Cell Biol. 2010;89:339-48 pubmed publisher
    ..The increase in Tpk levels produced an imbalance with Bcy1 levels. Our data suggest that the signaling specificity through PKA in yeast could be mediated by a particular subcellular localization of each isoform of Tpk. ..
  16. Andreone L, Velásquez E, Abramovich D, Ambao V, Loreti N, Croxatto H, et al. Regulation of inhibin/activin expression in rat early antral follicles. Mol Cell Endocrinol. 2009;309:48-54 pubmed publisher
    ..These results show that FSH and the steroid follicular microenvironment differentially modulate the gene expression of inhibin/activin subunits, their assembly and secretion. ..
  17. Inchauspe C, Martini F, Forsythe I, Uchitel O. Functional compensation of P/Q by N-type channels blocks short-term plasticity at the calyx of Held presynaptic terminal. J Neurosci. 2004;24:10379-83 pubmed
    ..We conclude that one physiological function of P/Q channels is to provide additional facilitatory drive, so contributing to maintenance of transmission as vesicles are depleted during high throughput synaptic transmission. ..
  18. Mart n M, Sender P, Peir S, de Mendoza D, Magni C. Acid-inducible transcription of the operon encoding the citrate lyase complex of Lactococcus lactis Biovar diacetylactis CRL264. J Bacteriol. 2004;186:5649-60 pubmed publisher
  19. González Bardeci N, Caramelo J, Blumenthal D, Rinaldi J, Rossi S, Moreno S. The PKA regulatory subunit from yeast forms a homotetramer: Low-resolution structure of the N-terminal oligomerization domain. J Struct Biol. 2016;193:141-54 pubmed publisher
    ..These findings indicate that the oligomerization states of PKA R subunits is more diverse than previously thought, and suggest that this might allow some forms of PKA to interact with a wide range of intracellular partners. ..
  20. Merli M, Cirulli B, Menendez Bravo S, Cricco J. Heme A synthesis and CcO activity are essential for Trypanosoma cruzi infectivity and replication. Biochem J. 2017;474:2315-2332 pubmed publisher
    ..cruzi survival, proliferation and infectivity. This evidence supports that T. cruzi depends on the respiratory chain activity along its life cycle, being CcO an essential terminal oxidase. ..