Experts and Doctors on protein serine threonine kinases in United States

Summary

Locale: United States
Topic: protein serine threonine kinases

Top Publications

  1. Chi Y, Huddleston M, Zhang X, Young R, Annan R, Carr S, et al. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev. 2001;15:1078-92 pubmed
    ..Simultaneous down-regulation of both transcriptional regulatory proteins and RNA polymerase may enhance the potency and specificity of transcriptional inhibition by Srb10. ..
  2. Sautin Y, Crawford J, Svetlov S. Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line. Am J Physiol Cell Physiol. 2001;281:C2010-9 pubmed
    ..Cell protection by LPA involves activation of the mitogen-activated protein kinase Erk1/Erk2 cascade and PI 3-kinase-dependent phosphorylation of Akt. ..
  3. Kamei T, Jones S, Chapman B, MCGonigle K, Dai G, Soares M. The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells. Mol Endocrinol. 2002;16:1469-81 pubmed
    ..In summary, activation of the PI3-K/Akt signaling pathway regulates the development of the differentiated trophoblast giant cell phenotype. ..
  4. Li J, Kinoshita T, Pandey S, Ng C, Gygi S, Shimazaki K, et al. Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase. Nature. 2002;418:793-7 pubmed
  5. Gray J, Moughon S, Kortemme T, Schueler Furman O, Misura K, Morozov A, et al. Protein-protein docking predictions for the CAPRI experiment. Proteins. 2003;52:118-22 pubmed
    ..Using a preliminary version of the protocol in round 1, target 1 was predicted within 8.8 A although few contacts were correct. For targets 2 and 3, the interface locations and a small fraction of the contacts were correctly identified. ..
  6. Yamane K, Chen J, Kinsella T. Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. Cancer Res. 2003;63:3049-53 pubmed
    ..These results indicate that both TopBP1 and BRCA1 specifically regulate the G(2)-M checkpoint, partially compensating each function. ..
  7. Kanadia R, Urbinati C, Crusselle V, Luo D, Lee Y, Harrison J, et al. Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3. Gene Expr Patterns. 2003;3:459-62 pubmed
    ..Our studies reveal a striking overlap between the expression of Dmpk and the muscleblind genes during development of the limbs, nervous system and various muscles, including the diaphragm and tongue. ..
  8. Lavenburg K, Ivey J, Hsu T, Muise Helmericks R. Coordinated functions of Akt/PKB and ETS1 in tubule formation. FASEB J. 2003;17:2278-80 pubmed
    ..Taken together, our results show that ETS1 and Akt control different aspects of cell motility that are integrated in the precise regulation of vascular tubule formation. ..
  9. Yue Y, Lypowy J, Hedhli N, Abdellatif M. Ras GTPase-activating protein binds to Akt and is required for its activation. J Biol Chem. 2004;279:12883-9 pubmed
    ..Thus, we propose that Ras-GAP interacts with Akt and is necessary for its activation, possibly via integrin-linked kinase-mediated phosphorylation of Ser-473. The data suggest that this effect is independent of Ras activity. ..

More Information

Publications300 found, 100 shown here

  1. Liao X, Thrasher J, Holzbeierlein J, Stanley S, Li B. Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer. Endocrinology. 2004;145:2941-9 pubmed
    ..These findings suggest that GSK-3beta activity is required for androgen-stimulated gene expression in prostate cancer cells. ..
  2. Ammanamanchi S, Brattain M. Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells. J Biol Chem. 2004;279:32620-5 pubmed
    ..Significantly, SAHA-mediated RI regeneration restored the TGF-beta response in breast cancer cells. ..
  3. Lin H, Hsieh F, Song H, Lin J. Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. Br J Cancer. 2005;93:1372-81 pubmed
  4. Chandler D, Singh R, Caldwell L, Bitler J, Lozano G. Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4. Cancer Res. 2006;66:9502-8 pubmed
    ..A stepwise model for malignant conversion by which alternate forms of MDM2 and MDM4 place selective pressure on the cells to acquire additional alterations in the p53 pathway is herein proposed. ..
  5. Kass E, Ahn J, Tanaka T, Freed Pastor W, Keezer S, Prives C. Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. J Biol Chem. 2007;282:30311-21 pubmed
    ..These findings suggest a mechanism for stabilization of Chk2 in response to DNA damage via phosphorylation at Ser-456 and proteasome-dependent turnover of Chk2 protein via dephosphorylation of the same residue. ..
  6. Sharma P, Chakraborty R, Wang L, Min B, Tremblay M, Kawahara T, et al. Redox regulation of interleukin-4 signaling. Immunity. 2008;29:551-64 pubmed publisher
  7. Schmit T, Zhong W, Setaluri V, Spiegelman V, Ahmad N. Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells. J Invest Dermatol. 2009;129:2843-53 pubmed publisher
    ..This study suggests that Plk1 may have a functional relevance toward melanoma development and/or progression. We suggest that the targeting of Plk1 may be a viable approach for the treatment of melanoma. ..
  8. Schmit T, Zhong W, Nihal M, Ahmad N. Polo-like kinase 1 (Plk1) in non-melanoma skin cancers. Cell Cycle. 2009;8:2697-702 pubmed
  9. Gulhati P, Cai Q, Li J, Liu J, Rychahou P, Qiu S, et al. Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer. Clin Cancer Res. 2009;15:7207-16 pubmed publisher
  10. Taub M, Springate J, Cutuli F. Targeting of renal proximal tubule Na,K-ATPase by salt-inducible kinase. Biochem Biophys Res Commun. 2010;393:339-44 pubmed publisher
    ..Once phosphorylated, TORCs enter the nucleus, and activate transcription of the ATP1B1 gene encoding for the Na,K-ATPase beta subunit. ..
  11. Liu X, Sempere L, Ouyang H, Memoli V, Andrew A, Luo Y, et al. MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest. 2010;120:1298-309 pubmed publisher
    ..Together, these findings revealed that miR-31 acts as an oncogenic miRNA (oncomir) in lung cancer by targeting specific tumor suppressors for repression. ..
  12. Demidenko Z, Korotchkina L, Gudkov A, Blagosklonny M. Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci U S A. 2010;107:9660-4 pubmed publisher
    ..Thus, in spite of its ability to induce cell cycle arrest, p53 can act as a suppressor of cellular senescence. ..
  13. Torres V, Boletta A, Chapman A, Gattone V, Pei Y, Qian Q, et al. Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases. Clin J Am Soc Nephrol. 2010;5:1312-29 pubmed publisher
    ..If effective, lower dosages than those used to prevent rejection would minimize side effects. Combination therapy with other effective drugs could improve tolerability and results. ..
  14. Tietjen J, Zhang D, Rodríguez Molina J, White B, Akhtar M, Heidemann M, et al. Chemical-genomic dissection of the CTD code. Nat Struct Mol Biol. 2010;17:1154-61 pubmed publisher
    ..We propose that Ser7-P could facilitate elongation and suppress cryptic transcription. ..
  15. Dhandapani K, Wade F, Mahesh V, Brann D. Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways. Endocrinology. 2005;146:2749-59 pubmed
  16. Hiromasa Y, Hu L, Roche T. Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2. J Biol Chem. 2006;281:12568-79 pubmed
    ..Ligand-induced changes that interfere with PDHK2 binding to GST-L2(red) may involve release of an interdomain cross arm between PDHK2 subunits in which Trp-383 plays a critical anchoring role. ..
  17. Mercer S, Ewton D, Shah S, Naqvi A, Friedman E. Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas. Cancer Res. 2006;66:5143-50 pubmed
    ..This survival function is maintained in rhabdomyosarcoma, where Mirk may be a novel therapeutic target. ..
  18. Thiaville M, Pan Y, Gjymishka A, Zhong C, Kaufman R, Kilberg M. MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. J Biol Chem. 2008;283:10848-57 pubmed publisher
    ..Collectively, these results document a critical interdependence between the MEK-ERK MAPK signaling pathway and the amino acid stress-activated pathway. ..
  19. Rong R, He Q, Liu Y, Sheikh M, Huang Y. TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway. Oncogene. 2002;21:1062-70 pubmed
    ..In conclusion, we have identified PI3-K as an effector of TC21 and demonstrated that the PI3-K/Akt signaling pathway plays important roles in TC21-mediated transformation and cell survival. ..
  20. Ascano M, Robbins D. An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling. Mol Cell Biol. 2004;24:10397-405 pubmed
    ..Our results here enhance our understanding of one of the least characterized, yet critical, components of Hh signal transduction. ..
  21. Dhandapani K, Wade F, Wakade C, Mahesh V, Brann D. Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFkappaB. J Neurochem. 2005;95:9-19 pubmed
    ..SCF represents a novel therapeutic target in the treatment of neurodegenerative disease. ..
  22. Esau C, Davis S, Murray S, Yu X, Pandey S, Pear M, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 2006;3:87-98 pubmed
    ..These results implicate miR-122 as a key regulator of cholesterol and fatty-acid metabolism in the adult liver and suggest that miR-122 may be an attractive therapeutic target for metabolic disease. ..
  23. Tran T, Uhl M, Ma J, Janssen L, Sriram V, Aulwurm S, et al. Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model. Neuro Oncol. 2007;9:259-70 pubmed
    ..Together, these results suggest that treatment with a TGF-betaRI inhibitor may be useful in the treatment of glioblastoma. ..
  24. Fujii H, Zhu J. Arabidopsis mutant deficient in 3 abscisic acid-activated protein kinases reveals critical roles in growth, reproduction, and stress. Proc Natl Acad Sci U S A. 2009;106:8380-5 pubmed publisher
    ..These results demonstrate that the protein kinases SnRK2.2, SnRK2.3, and SnRK2.6 have redundant functions, and suggest that ABA signaling is critical for plant growth and reproduction. ..
  25. Shanware N, Zhan L, Hutchinson J, Kim S, Williams L, Tibbetts R. Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. PLoS ONE. 2010;5:e12173 pubmed publisher
    ..These studies define overlapping and distinct modes of CREB and ATF1 regulation by phosphorylation that may ensure concerted changes in gene expression mediated by these factors. ..
  26. Suen K, Bustelo X, Barbacid M. Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells. Oncogene. 1995;11:825-31 pubmed
    ..These observations argue against a critical regulatory role of the 14-3-3 proteins in the Raf mitogenic pathway. ..
  27. Megidish T, Cooper J, Zhang L, Fu H, Hakomori S. A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. J Biol Chem. 1998;273:21834-45 pubmed
  28. Li C, Kao R, Ha T, Kelley J, Browder I, Williams D. Early activation of IKKbeta during in vivo myocardial ischemia. Am J Physiol Heart Circ Physiol. 2001;280:H1264-71 pubmed
    ..The results suggest that in vivo I/R rapidly induces IKKbeta activity and increases IkappaBalpha phosphorylation and degradation, resulting in NF-kappaB activation in the myocardium...
  29. Ihn H, Ihn Y, Trojanowska M. Spl phosphorylation induced by serum stimulates the human alpha2(I) collagen gene expression. J Invest Dermatol. 2001;117:301-8 pubmed
    ..In conclusion, this study characterized response elements that mediate serum stimulation of the human alpha2(I) collagen promoter and suggests that serum stimulation was mediated via Sp1/Sp3 binding sites in this promoter. ..
  30. Holland P, Milne A, Garka K, Johnson R, Willis C, Sims J, et al. Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. J Biol Chem. 2002;277:16229-40 pubmed
    ..Treatment of cells with nocodazole leads to dramatic reorganization of Bicd2, and correlates with Nek8 phosphorylation. This may be indicative of a role for Nek8 and Bicd2 associated with cell cycle independent microtubule dynamics. ..
  31. Williams B, Mirzoeva O, Morgan W, Lin J, Dunnick W, Petrini J. A murine model of Nijmegen breakage syndrome. Curr Biol. 2002;12:648-53 pubmed
    ..We propose that the ATM-Mre11 complex DNA damage response pathway is essential and that ATM or the Mre11 complex serves as a nexus to additional components of the pathway. ..
  32. Shaw S, Bencherif M, Marrero M. Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid. J Biol Chem. 2002;277:44920-4 pubmed
    ..These findings identify novel mechanisms of receptor interactions relevant to neuronal viability and suggest novel therapeutic strategies to optimize neuroprotection. ..
  33. McEachern K, Archey W, Douville K, Arrick B. BRCA1 splice variants exhibit overlapping and distinct transcriptional transactivation activities. J Cell Biochem. 2003;89:120-32 pubmed
    ..These results show that BRCA1 isoforms have both overlapping and distinct transcriptional transactivation activity, and that a mutant form of BRCA1 implicated in carcinogenesis is not devoid of all activity. ..
  34. Laszlo G, Nathanson N. Src family kinase-independent signal transduction and gene induction by leukemia inhibitory factor. J Biol Chem. 2003;278:27750-7 pubmed
    ..These results demonstrate that IL-6 family cytokines can activate a full repertoire of signaling pathways and induce gene expression independent of SFKs. ..
  35. Chini C, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem. 2003;278:30057-62 pubmed
    ..Taken together, these data imply a potentially critical role for Claspin in replication checkpoint control in mammalian cells. ..
  36. Rusinol A, Thewke D, Liu J, Freeman N, Panini S, Sinensky M. AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis. J Biol Chem. 2004;279:1392-9 pubmed
    ..Somewhat surprisingly, small interfering RNA knockdown of BAX resulted in a complete block of the induction of apoptosis by 25-hydroxycholesterol. ..
  37. Schneper L, Krauss A, Miyamoto R, Fang S, Broach J. The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection. Eukaryot Cell. 2004;3:108-20 pubmed
    ..From these observations, we conclude that the PKA pathway and Mob2/Cbk1 act in parallel to determine bud site selection and promote cell cycle progression. ..
  38. Pannu J, Gore Hyer E, Yamanaka M, Smith E, Rubinchik S, Dong J, et al. An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma. Arthritis Rheum. 2004;50:1566-77 pubmed
    ..This study indicates that an increased TGFbetaRI:TGFbetaRII ratio may underlie aberrant TGFbeta signaling in SSc and contribute to elevated basal collagen production, which is insensitive to TGFbeta signaling blockade via DeltakRII. ..
  39. Sautin Y, Lu M, Gaugler A, Zhang L, Gluck S. Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells. Mol Cell Biol. 2005;25:575-89 pubmed
  40. Mills E, Lamonica K, Hong T, Pagliaruli T, Mulrooney J, Grabel L. Roles for Rho/ROCK and vinculin in parietal endoderm migration. Cell Commun Adhes. 2005;12:9-22 pubmed
    ..Addition of Y-27632 to vinculin-null outgrowth cultures further stimulates migration an additional 2-fold, supporting the conclusion that Rho/ROCK and vinculin regulate parietal endoderm outgrowth by distinct pathways. ..
  41. Bettinger B, Amberg D. The MEK kinases MEKK4/Ssk2p facilitate complexity in the stress signaling responses of diverse systems. J Cell Biochem. 2007;101:34-43 pubmed
    ..We will also highlight evidence supporting a role for MEKK4 in mediating actin recovery following osmotic shock in mammalian cells. ..
  42. Ray A, Mir S, Wani G, Zhao Q, Battu A, Zhu Q, et al. Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation. Mol Cell Biol. 2009;29:6206-19 pubmed publisher
    ..We propose that the SWI/SNF chromatin remodeling function is utilized to increase the DNA accessibility of NER machinery and checkpoint factors at the damage site, which influences NER and ensures genomic integrity. ..
  43. Lee J, Goodarzi A, Jeggo P, Paull T. 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J. 2010;29:574-85 pubmed publisher
    ..We also find that the BRCT domains of 53BP1 affect the overall structure of 53BP1 multimers and that this structure is important for promoting ATM phosphorylation of substrates as well as for the repair of DNA DSBs in mammalian cells. ..
  44. Korotchkina L, Leontieva O, Bukreeva E, Demidenko Z, Gudkov A, Blagosklonny M. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY). 2010;2:344-52 pubmed
    ..We conclude that status of the mTOR pathway can determine, at least in part, the choice between senescence and quiescence in p53-arrested cells. ..
  45. Pancholi V, Boel G, Jin H. Streptococcus pyogenes Ser/Thr kinase-regulated cell wall hydrolase is a cell division plane-recognizing and chain-forming virulence factor. J Biol Chem. 2010;285:30861-74 pubmed publisher
    ..CdhA is thus an important therapeutic target. ..
  46. Penton A, Chen Y, Staehling Hampton K, Wrana J, Attisano L, Szidonya J, et al. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell. 1994;78:239-50 pubmed
    ..Brk43E is the product of the gene saxophone, which also interacts with dpp. We conclude that dpp signaling in vivo is mediated by at least two receptors, Brk25D and Brk43E. ..
  47. Mitchell D, Sprague G. The phosphotyrosyl phosphatase activator, Ncs1p (Rrd1p), functions with Cla4p to regulate the G(2)/M transition in Saccharomyces cerevisiae. Mol Cell Biol. 2001;21:488-500 pubmed
    ..Strains lacking both NCS1 and NOH1 were inviable and arrested as unbudded cells, implying that PTPA function is required for proper G(1) progression. ..
  48. Zhou H, Yan F, Tai H. Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases. J Pharmacol Exp Ther. 2001;298:1243-51 pubmed
    ..Furthermore, the results obtained with PKC inhibitors in assessing the role of PKC in agonist-induced receptor phosphorylation should be interpreted with caution. ..
  49. Steveson T, Zhao G, Keutmann H, Mains R, Eipper B. Access of a membrane protein to secretory granules is facilitated by phosphorylation. J Biol Chem. 2001;276:40326-37 pubmed
    ..The increased ability of solubilized PAM-1 TS/DD to aggregate at neutral pH may play an important role in its altered trafficking. ..
  50. Amack J, Mahadevan M. The myotonic dystrophy expanded CUG repeat tract is necessary but not sufficient to disrupt C2C12 myoblast differentiation. Hum Mol Genet. 2001;10:1879-87 pubmed
    ..Our observations in this system may be relevant to the lack of a regenerative response to continued muscle wasting in DM, and point to defects in early events in the myogenic response to muscle damage. ..
  51. Murillo H, Schmidt L, Tindall D. Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-2. Cancer Res. 2001;61:7408-12 pubmed
    ..These findings suggest that the androgen-independent C4 and C4-2 cells can be killed by selectively inhibiting their HER-2/neu signaling pathway and provide insights into the mechanism of action of AG825 in PCa cells. ..
  52. Li X, Liu L, Tupper J, Bannerman D, Winn R, Sebti S, et al. Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells. J Biol Chem. 2002;277:15309-16 pubmed
    ..Our data indicate that inhibition of protein geranylgeranylation and RhoA pathways induce apoptosis in HUVEC and that induction of p53 or other proapoptotic proteins is required for this process. ..
  53. Yang T, Poovaiah B. A calmodulin-binding/CGCG box DNA-binding protein family involved in multiple signaling pathways in plants. J Biol Chem. 2002;277:45049-58 pubmed
    ..These results suggest that the AtSR gene family encodes a family of calmodulin-binding/DNA-binding proteins involved in multiple signal transduction pathways in plants. ..
  54. He Z, Ma W, Liu G, Zhang Y, Bode A, Dong Z. Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. J Biol Chem. 2003;278:10588-93 pubmed
  55. Keniry M, Sprague G. Identification of p21-activated kinase specificity determinants in budding yeast: a single amino acid substitution imparts Ste20 specificity to Cla4. Mol Cell Biol. 2003;23:1569-80 pubmed
    ..Remarkably, the substitution of a single amino acid, threonine 818, from Ste20 into an otherwise wild-type Cla4, Cla4D772T, conferred the ability to perform many Ste20-specific functions. ..
  56. Young T, Wang Q, PE ERY T, Mathews M. The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol. 2003;23:6373-84 pubmed
    ..The isolated I-mfa domain acts as a dominant negative inhibitor. Activation of the HIV-1 LTR by HIC in NIH 3T3 cells occurs at the RNA level and is mediated by direct interactions with P-TEFb. ..
  57. Kim J, Solis R, Arias E, Cartee G. Postcontraction insulin sensitivity: relationship with contraction protocol, glycogen concentration, and 5' AMP-activated protein kinase phosphorylation. J Appl Physiol (1985). 2004;96:575-83 pubmed
    ..These data suggest that contraction-induced AMPK phosphorylation and decrease in glycogen may be necessary but are not sufficient for the postcontraction increase in insulin-stimulated GT in rat skeletal muscle. ..
  58. Deng X, Mercer S, Shah S, Ewton D, Friedman E. The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase. J Biol Chem. 2004;279:22498-504 pubmed
    ..In addition, depletion of Mirk by RNA(i) in postmitotic C2C12 myoblasts decreased protein but not mRNA levels of p27, suggesting that stabilization of p27 by Mirk also occurs during differentiation. ..
  59. Villafuerte B, Phillips L, Rane M, Zhao W. Insulin-response element-binding protein 1: a novel Akt substrate involved in transcriptional action of insulin. J Biol Chem. 2004;279:36650-9 pubmed
    ..Identification of a novel target of Akt that appears to mediate signals specific for insulin action should provide further insight into the mechanism of insulin action at the genomic level. ..
  60. Yan T, Desai A, Jacobberger J, Sramkoski R, Loh T, Kinsella T. CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. Mol Cancer Ther. 2004;3:1147-57 pubmed
    ..The two signaling kinases seem to work cooperatively to ensure that 6-TG damaged cells arrest at these cell cycle checkpoints. ..
  61. Liu J, Schlosser R, Ma W, Dong Z, Feng H, Lui L, et al. Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways. Exp Eye Res. 2004;79:393-403 pubmed
    ..Together, our results for the first time reveal that by regulating multiple signaling pathways the two alpha-crystallins can prevent stress-induced apoptosis through different mechanisms. ..
  62. Kachergus J, Mata I, Hulihan M, Taylor J, Lincoln S, Aasly J, et al. Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations. Am J Hum Genet. 2005;76:672-80 pubmed
    ..Our work highlights the fact that a proportion of clinically typical, late-onset PD cases have a genetic basis. ..
  63. Safina A, Vandette E, Bakin A. ALK5 promotes tumor angiogenesis by upregulating matrix metalloproteinase-9 in tumor cells. Oncogene. 2007;26:2407-22 pubmed
    ..Collectively, our results show that TGF-beta-ALK5-MAPK signaling in tumor cells promotes tumor angiogenesis and MMP-9 is an important component of this program. ..
  64. Hontz A, Li S, Lingle W, Negron V, Bruzek A, Salisbury J, et al. Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia. Cancer Res. 2007;67:2957-63 pubmed
  65. Spicer L, Aad P, Allen D, Mazerbourg S, Payne A, Hsueh A. Growth differentiation factor 9 (GDF9) stimulates proliferation and inhibits steroidogenesis by bovine theca cells: influence of follicle size on responses to GDF9. Biol Reprod. 2008;78:243-53 pubmed
  66. Luo G, Gruhler A, Liu Y, Jensen O, Dickson R. The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover. J Biol Chem. 2008;283:10433-44 pubmed publisher
    ..Eisosomes then control endocytosis to align the composition and function of the plasma membrane to match demand. ..
  67. Lu W, László C, Miao Z, Chen H, Wu S. The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2. J Biol Chem. 2009;284:24281-8 pubmed publisher
    ..The results presented above led us to propose that NOS mediates UV-induced eIF2alpha phosphorylation by activation of both PERK and GCN2 via oxidative stress and l-arginine starvation signaling pathways. ..
  68. Piccirillo S, White M, Murphy J, Law D, Honigberg S. The Rim101p/PacC pathway and alkaline pH regulate pattern formation in yeast colonies. Genetics. 2010;184:707-16 pubmed publisher
    ..Thus, the Rim101 pathway mediates colony patterning by responding to cell-to-cell pH signals. Cell-to-cell signals coupled with nutrient gradients may allow efficient spore formation and spore dispersal in natural environments. ..
  69. Katta A, Kakarla S, Wu M, Paturi S, Gadde M, Arvapalli R, et al. Altered regulation of contraction-induced Akt/mTOR/p70S6k pathway signaling in skeletal muscle of the obese Zucker rat. Exp Diabetes Res. 2009;2009:384683 pubmed publisher
    ..These results suggest that contraction-induced activation of p70S6k signaling is altered in the muscle of the insulin resistant obese Zucker rat. ..
  70. Gershburg S, Murphy L, Marschall M, Gershburg E. Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization. Biochem J. 2010;431:227-35 pubmed publisher
    ..These results reiterate the unique features of this group of kinases and present an opportunity for designing more specific antiviral compounds...
  71. Frisch R, Singleton K, Moses P, Gonzalez I, Carango P, Marks H, et al. Effect of triplet repeat expansion on chromatin structure and expression of DMPK and neighboring genes, SIX5 and DMWD, in myotonic dystrophy. Mol Genet Metab. 2001;74:281-91 pubmed
    ..These results suggest that the CTG repeat expansion leads to a decrease in DMPK mRNA levels by affecting splicing at the 3' end of the DMPK pre-mRNA transcript. ..
  72. Kumagai A, Kim S, Dunphy W. Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J Biol Chem. 2004;279:49599-608 pubmed
    ..Taken together, these results indicate that the checkpoint-dependent phosphorylation of Chk1 is a multistep process involving activation of the ATR-ATRIP complex at replication forks and presentation of Chk1 to this complex by Claspin. ..
  73. Jung J, Traugh J. Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141. J Biol Chem. 2005;280:40025-31 pubmed
    ..A model is proposed suggesting that binding of Cdc42 localizes Pak2 to the endoplasmic reticulum, where autophosphorylation alters association of the two proteins. ..
  74. Praetorius Ibba M, Wang Q, Wani G, El Mahdy M, Zhu Q, Qin S, et al. Role of Claspin in regulation of nucleotide excision repair factor DDB2. DNA Repair (Amst). 2007;6:578-87 pubmed
    ..Taken together, these findings reveal physical and functional interplay between Claspin and NER-related proteins and demonstrate crosstalk between the DNA damage checkpoint control and DNA damage repair pathways. ..
  75. Tu Y, Li F, Wu C. Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. Mol Biol Cell. 1998;9:3367-82 pubmed
    ..These results identify a novel Nck-related SH2- and SH3-domain-containing protein and suggest that it may function as an adaptor protein connecting the growth factor receptor-signaling pathways with the integrin-signaling pathways. ..
  76. Liu S, Lane W, Lienhard G. Cloning and preliminary characterization of a 105 kDa protein with an N-terminal kinase-like domain. Biochim Biophys Acta. 2000;1517:148-52 pubmed
    ..By immunoblotting, it was found that the protein was widely expressed in mouse tissues, and concentrated in the cytosol and low density microsome fractions of 3T3-L1 adipocytes. ..
  77. Mengshol J, Vincenti M, Brinckerhoff C. IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways. Nucleic Acids Res. 2001;29:4361-72 pubmed
  78. Balasubramanian S, Efimova T, Eckert R. Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. J Biol Chem. 2002;277:1828-36 pubmed
    ..These studies show that in normal human keratinocytes EGCG markedly increases, via a MAPK signaling mechanism, AP1 factor-associated responses. ..
  79. Cenni V, Döppler H, Sonnenburg E, Maraldi N, Newton A, Toker A. Regulation of novel protein kinase C epsilon by phosphorylation. Biochem J. 2002;363:537-45 pubmed
    ..However, the regulation of this phosphorylation is different for novel and conventional PKCs. Specifically, the phosphorylation of novel PKCs is regulated rather than constitutive. ..
  80. Qiao L, Zhande R, Jetton T, Zhou G, Sun X. In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents. J Biol Chem. 2002;277:26530-9 pubmed
    ..Taken together, these data strongly suggest that unknown serine kinase activity and Ser(789) phosphorylation of IRS-1 may play an important role in attenuating insulin signaling in insulin-resistant animal models. ..
  81. He Y, Nakao H, Tan S, Polyak S, Neddermann P, Vijaysri S, et al. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J Virol. 2002;76:9207-17 pubmed
  82. Powell D, Rane M, Joughin B, Kalmukova R, Hong J, Tidor B, et al. Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol. 2003;23:5376-87 pubmed
    ..These data suggest that MAPKAPK2-mediated phosphorylation regulates 14-3-3zeta functions, and this MAPKAPK2 activity may represent a novel pathway mediating p38 MAPK-dependent inflammation. ..
  83. Takada Y, Singh S, Aggarwal B. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 2004;279:15096-104 pubmed
    ..Overall, our results demonstrate the identification of a p65 peptide that can selectively inhibit NF-kappaB activation induced by various inflammatory stimuli, down-regulate NF-kappaB-mediated gene expression, and up-regulate apoptosis. ..
  84. Reagan Shaw S, Ahmad N. Silencing of polo-like kinase (Plk) 1 via siRNA causes induction of apoptosis and impairment of mitosis machinery in human prostate cancer cells: implications for the treatment of prostate cancer. FASEB J. 2005;19:611-3 pubmed
    ..Thus, our study suggested that 1) Plk1 plays a critical role in the process of PCa development and 2) gene therapeutic approaches aimed at Plk1 or the pharmacological inhibitors of Plk1 may be developed for the management of PCa. ..
  85. Subramanya A, Yang C, McCormick J, Ellison D. WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron. Kidney Int. 2006;70:630-4 pubmed
  86. Jing M, Ismail Beigi F. Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation. Am J Physiol Cell Physiol. 2007;292:C477-87 pubmed
    ..However, LKB1 was associated with total p-AMPKalpha. We conclude that activation of AMPK plays both a sufficient and a necessary role in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation. ..
  87. Cen L, Arnoczky K, Hsieh F, Lin H, Qualman S, Yu S, et al. Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma. Mod Pathol. 2007;20:936-46 pubmed
    ..These protein kinases may play roles in the development or tumor progression of rhabdomyosarcomas and thus may serve as novel targets for therapeutic intervention...
  88. Li H, Costantini C, Scrable H, Weindruch R, Puglielli L. Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R. Neurobiol Aging. 2009;30:2010-20 pubmed publisher
    ..Such an event is opposed by caloric restriction, a model of delayed aging, and favored by the p44 transgene in p44(+/+) animals, a model of accelerated aging. ..
  89. Gasparyan H, Xu L, Petreaca R, Rex A, Small V, Bhogal N, et al. Yeast telomere capping protein Stn1 overrides DNA replication control through the S phase checkpoint. Proc Natl Acad Sci U S A. 2009;106:2206-11 pubmed publisher
    ..During replication stress, the mislocalized Stn1 may inappropriately promote Pol alpha in a manner that interferes with Rad53 effector mechanisms controlling replication fork integrity. ..
  90. Meng Q, Hagemeier S, Kuny C, Kalejta R, Kenney S. Simian virus 40 T/t antigens and lamin A/C small interfering RNA rescue the phenotype of an Epstein-Barr virus protein kinase (BGLF4) mutant. J Virol. 2010;84:4524-33 pubmed publisher
    ..These results suggest that essential roles of EBV-PK during lytic viral replication include the phosphorylation and dispersion of lamin A/C. ..
  91. Donovan M, Romano P, Tibbetts M, Hammond C. Characterization of the KIN2 gene product in Saccharomyces cerevisiae and comparison between the kinase activities of p145KIN1 and p145KIN2. Yeast. 1994;10:113-24 pubmed
    ..It remains to be seen if these two yeast protein kinases share any functional relationships or substrates in vivo. ..
  92. Estevez M, Attisano L, Wrana J, Albert P, Massague J, Riddle D. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature. 1993;365:644-9 pubmed
    ..When expressed in monkey COS cells, the daf-4 receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family. ..