Genomes and Genes
Experts and Doctors on protein precursors in United States
Locale: United States
Topic: protein precursors
Publications146 found, 100 shown here
- Wu C, Wu F, Pan J, Morser J, Wu Q. Furin-mediated processing of Pro-C-type natriuretic peptide. J Biol Chem. 2003;278:25847-52 pubmed..The furin-processed CNP was shown to be biologically active in a cell-based cGMP assay. These results demonstrate that furin is a critical enzyme for the processing of human pro-CNP. ..
- Alagramam K, Stahl J, Jones S, Pawlowski K, Wright C. Characterization of vestibular dysfunction in the mouse model for Usher syndrome 1F. J Assoc Res Otolaryngol. 2005;6:106-18 pubmed
- Pratt W, Kelley A. Striatal muscarinic receptor antagonism reduces 24-h food intake in association with decreased preproenkephalin gene expression. Eur J Neurosci. 2005;22:3229-40 pubmed
- Baker M, Mackenzie I, Pickering Brown S, Gass J, Rademakers R, Lindholm C, et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 2006;442:916-9 pubmed..Our results identify mutations in PGRN as a cause of neurodegenerative disease and indicate the importance of PGRN function for neuronal survival. ..
- Lee J, Leslie J, Bowden R. Expression and function of sex pheromones and receptors in the homothallic ascomycete Gibberella zeae. Eukaryot Cell. 2008;7:1211-21 pubmed publisher..Thus, one of the putative pheromone-receptor pairs (ppg1/pre2) enhances, but is not essential for, selfing and outcrossing in G. zeae whereas no functional role was found for the other pair (ppg2/pre1). ..
- Finch N, Carrasquillo M, Baker M, Rutherford N, Coppola G, DeJesus Hernandez M, et al. TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers. Neurology. 2011;76:467-74 pubmed publisher..In our study, TMEM106B SNPs significantly reduced the disease penetrance in patients with GRN mutations, potentially by modulating GRN levels. These findings hold promise for the development of future protective therapies for FTLD. ..
- Kocerha J, Kouri N, Baker M, Finch N, DeJesus Hernandez M, Gonzalez J, et al. Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations. BMC Genomics. 2011;12:527 pubmed publisher..Our study suggests that miRNAs may contribute to the pathogenesis of FTLD-TDP caused by PGRN mutations and provides new insight into potential future therapeutic options. ..
- McCarthy M, Duchemin A, Neff N, Hadjiconstantinou M. CREB involvement in the regulation of striatal prodynorphin by nicotine. Psychopharmacology (Berl). 2012;221:143-53 pubmed publisher..Dopamine D1 receptor stimulation by nAChR-released dopamine appears to be an underlying mechanism. Altered Dyn synthesis might be relevant for the behavioral actions of nicotine and especially its aversive properties. ..
- Milwid J, Elman J, Li M, Shen K, Manrai A, Gabow A, et al. Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol Ther. 2014;22:999-1007 pubmed publisher..Greater than 85% of secreted factors were recaptured that were otherwise undetected by proteomic methods, and remarkable hit rates of 18% in vitro and 9% in vivo were achieved. ..
- Sahu A, White J, Kalra P, Kalra S. Hypothalamic neuropeptide Y gene expression in rats on scheduled feeding regimen. Brain Res Mol Brain Res. 1992;15:15-8 pubmed
- Lee B, Cho G, Norgren R, Junier M, Hill D, Tapia V, et al. TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci. 2001;17:107-26 pubmed
- Corrigan D, Kuszczak D, Rusinol A, Thewke D, Hrycyna C, Michaelis S, et al. Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24. Biochem J. 2005;387:129-38 pubmed..With this substrate, we demonstrate that insect cell membranes bearing recombinant Zmpste24 can also catalyse the second upstream endoproteolytic cleavage. ..
- Corcoran K, Patel N, Rameshwar P. Stromal derived growth factor-1alpha: another mediator in neural-emerging immune system through Tac1 expression in bone marrow stromal cells. J Immunol. 2007;178:2075-82 pubmed..Substance P, however, does not act as autocrine stimulator to induce the production of SDF-1alpha. This study adds SDF-1alpha as a mediator within the neural-immune-hemopoietic axis. ..
- Isola R, Zhang H, Tejwani G, Neff N, Hadjiconstantinou M. Dynorphin and prodynorphin mRNA changes in the striatum during nicotine withdrawal. Synapse. 2008;62:448-55 pubmed publisher..Heightened dynorphinergic tone might be responsible, in part, for the emergence of the negative affective states observed during nicotine withdrawal. ..
- Szabo F, Snyder N, Usdin T, Hoffman G. A direct neuronal connection between the subparafascicular and ventrolateral arcuate nuclei in non-lactating female rats. Could this pathway play a role in the suckling-induced prolactin release?. Endocrine. 2010;37:62-70 pubmed publisher..The presented findings suggest that the ascending fibers from the subparafascicular parvocellular nucleus might be in the pathway involved in the suckling-induced prolactin release. ..
- Gattone V, Andrews G, Niu F, Chadwick L, Klein R, Calvet J. Defective epidermal growth factor gene expression in mice with polycystic kidney disease. Dev Biol. 1990;138:225-30 pubmed
- Huang K, D hondt K, Riezman H, Lemmon S. Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast. EMBO J. 1999;18:3897-908 pubmed..Therefore, alternative mechanisms for clathrin assembly and coated vesicle formation, as well as the role of AP complexes and AP180-related proteins in these processes, must be considered. ..
- Carlos J, Paetzel M, Brubaker G, Karla A, Ashwell C, Lively M, et al. The role of the membrane-spanning domain of type I signal peptidases in substrate cleavage site selection. J Biol Chem. 2000;275:38813-22 pubmed..In contrast, certain mutants in the c-region of the signal peptide result in alternate site cleavage by both Lep and SipS enzymes...
- Stephens E, McCormick C, Pacyniak E, Griffin D, Pinson D, Sun F, et al. Deletion of the vpu sequences prior to the env in a simian-human immunodeficiency virus results in enhanced Env precursor synthesis but is less pathogenic for pig-tailed macaques. Virology. 2002;293:252-61 pubmed..The results of these studies indicate that the Vpu coding sequences upstream of Env may attenuate the level of Env precursor biosynthesis but significantly contribute to the pathogenesis of this SHIV in pig-tailed macaques. ..
- Ge G, Seo N, Liang X, Hopkins D, Hook M, Greenspan D. Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis. J Biol Chem. 2004;279:41626-33 pubmed..We also demonstrate that both pro- and mature OGN can regulate type I collagen fibrillogenesis, and that processing of the prodomain by BMP-1 potentiates the ability of OGN to modulate the formation of collagen fibrils. ..
- Will M, Vanderheyden W, Kelley A. Striatal opioid peptide gene expression differentially tracks short-term satiety but does not vary with negative energy balance in a manner opposite to hypothalamic NPY. Am J Physiol Regul Integr Comp Physiol. 2007;292:R217-26 pubmed..This double dissociation between striatal and hypothalamic peptide systems suggests a specific role for striatal PPE in relatively short-term food motivational states, but not in long-term metabolic responses to diet restriction. ..
- Sun X, Devine T, Challagundla K, Dai M. Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress. J Biol Chem. 2011;286:22730-41 pubmed publisher..Altogether, our results reveal that S27a plays a non-redundant role in mediating p53 activation in response to ribosomal stress via interplaying with MDM2. ..
- Le A, Friedman W. Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures. J Neurosci. 2012;32:703-12 pubmed publisher..These data demonstrate that increased extracellular proNGF levels following seizures are stabilized by altered MMP-7 enzymatic activity, leading to increased neuronal death via activation of p75(NTR). ..
- Sung M, Dalbey R. Identification of potential active-site residues in the Escherichia coli leader peptidase. J Biol Chem. 1992;267:13154-9 pubmed..This study thus defines two critical residues, serine 90 and aspartic acid 153, that may be directly involved in catalysis and provides evidence that leader peptidase belongs to a novel class of serine proteases. ..
- Molloy S, Thomas L, VanSlyke J, Stenberg P, Thomas G. Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J. 1994;13:18-33 pubmed..Finally, we show that proregion removal is necessary but not sufficient for enzyme activation. ..
- Duong F, Wickner W. The SecDFyajC domain of preprotein translocase controls preprotein movement by regulating SecA membrane cycling. EMBO J. 1997;16:4871-9 pubmed..These findings establish a functional relationship between SecA membrane insertion and preprotein translocation and show that SecDFyajC controls SecA membrane cycling to regulate the movement of the translocating preprotein. ..
- Yusof R, Clum S, Wetzel M, Murthy H, Padmanabhan R. Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro. J Biol Chem. 2000;275:9963-9 pubmed..These results suggest that heterodimerization of the NS3pro domain with NS2B generates additional specific interactions with the P2 and P3 residues of the substrates...
- Deucher A, Efimova T, Eckert R. Calcium-dependent involucrin expression is inversely regulated by protein kinase C (PKC)alpha and PKCdelta. J Biol Chem. 2002;277:17032-40 pubmed..These findings suggest that PKCalpha and PKCdelta are required for, and modulate, calcium-dependent keratinocyte differentiation in opposing directions. ..
- Hasan W, Pedchenko T, Krizsan Agbas D, Baum L, Smith P. Sympathetic neurons synthesize and secrete pro-nerve growth factor protein. J Neurobiol. 2003;57:38-53 pubmed..These findings suggest that a potential NGF-sympathetic neuron autocrine loop may exist in this prototypic target-dependent system, but that the secreted forms of this neurotrophin apparently do not support neuronal survival. ..
- Eckert R, Crish J, Efimova T, Balasubramanian S. Antioxidants regulate normal human keratinocyte differentiation. Biochem Pharmacol. 2004;68:1125-31 pubmed..Curcumin, for example, inhibits the differentiation-promoting activity of EGCG. This report discusses the mechanism of EGCG and curcumin action in regulating expression of involucrin, a marker of keratinocyte differentiation. ..
- Ernest Dodd M, Ristich V, Ray S, Lober R, Bollag W. Regulation of protein kinase D during differentiation and proliferation of primary mouse keratinocytes. J Invest Dermatol. 2005;125:294-306 pubmed..This work describes the inverse regulation of PKD during keratinocyte differentiation and proliferation and the pro-proliferative/anti-differentiative effects of PKD co-expression on keratinocyte maturation. ..
- Huffaker A, Pearce G, Veyrat N, Erb M, Turlings T, SARTOR R, et al. Plant elicitor peptides are conserved signals regulating direct and indirect antiherbivore defense. Proc Natl Acad Sci U S A. 2013;110:5707-12 pubmed publisher..These studies demonstrate that Peps are conserved signals across diverse plant families regulating antiherbivore defenses and are likely to be the missing functional homologs of systemin outside of the Solanaceae. ..
- Bogdan J, Nazario Larrieu J, Sarwar J, Alexander P, Blake M. Bordetella pertussis autoregulates pertussis toxin production through the metabolism of cysteine. Infect Immun. 2001;69:6823-30 pubmed..Therefore, the combined presence and metabolism of cysteine may be an important mechanism in the pathogenesis of B. pertussis. ..
- Zagon I, McLaughlin P. Opioids and differentiation in human cancer cells. Neuropeptides. 2005;39:495-505 pubmed..The absence of effects on cancer cell differentiation by a variety of other opioids supports the previously reported lack of growth effects of these compounds. ..
- Koch J, Moritz J, Lay D, Wilson M. Effect of melengestrol acetate as an alternative to induce molting in hens on the expression of yolk proteins and turnover of oviductal epithelium. Anim Reprod Sci. 2007;102:14-23 pubmed
- Koo B, Longpre J, Somerville R, Alexander J, Leduc R, Apte S. Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide. J Biol Chem. 2007;282:16146-54 pubmed..Thus, the propeptide is a key functional domain of ADAMTS9, mediating an unusual regulatory mechanism that may have evolved to ensure maximal activity of this protease at the cell surface. ..
- Dai L, Dewey E, Zitnan D, Luo C, Honegger H, Adams M. Identification, developmental expression, and functions of bursicon in the tobacco hawkmoth, Manduca sexta. J Comp Neurol. 2008;506:759-74 pubmed..Recombinant bursicon induces both wing expansion and tanning, whereas synthetic eclosion hormone induces only wing expansion...
- Musich P, Zou Y. Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A. Aging (Albany NY). 2009;1:28-37 pubmed
- Nagarajan P, Chin S, Wang D, Liu S, Sinha S, Garrett Sinha L. Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators. J Cell Sci. 2010;123:3566-75 pubmed publisher..Collectively, our data reveal that elevated expression of Ets1 has a much broader array of pro-tumorigenic effects on epithelial cells than previously appreciated. ..
- Alagramam K, Goodyear R, Geng R, Furness D, van Aken A, Marcotti W, et al. Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells. PLoS ONE. 2011;6:e19183 pubmed publisher..These results therefore provide genetic evidence consistent with PCDH15 and CDH23 being part of the tip-link complex and necessary for normal mechanotransduction. ..
- Bourguignon L, Wong G, Xia W, Man M, Holleran W, Elias P. Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction. J Dermatol Sci. 2013;72:32-44 pubmed publisher..Second, manipulation of matrix (HA) interaction with CD44 and RhoGTPase signaling could provide further novel therapeutic approaches that could be targeted for the treatment of various aging-related skin disorders. ..
- Strom M, Nunn D, Lory S. Posttranslational processing of type IV prepilin and homologs by PilD of Pseudomonas aeruginosa. Methods Enzymol. 1994;235:527-40 pubmed..aeruginosa, such inhibitors may be useful tools in the study of the role these peptidases play in bacterial virulence. ..
- Anderson E, Thomas L, Hayflick J, Thomas G. Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant. J Biol Chem. 1993;268:24887-91 pubmed..The potential use of alpha 1-PDX in manipulating the activation of proproteins in a tissue- and time-specific manner is discussed. ..
- Friedmann A, Malott K, Memoli V, Pai S, Yu X, North W. Products of vasopressin gene expression in small-cell carcinoma of the lung. Br J Cancer. 1994;69:260-3 pubmed..These results support the proposition that both normal and abnormal vasopressin gene expression occurs in small-cell carcinoma of the lung. ..
- Snyders S, Ramamurthy V, Oliver D. Identification of a region of interaction between Escherichia coli SecA and SecY proteins. J Biol Chem. 1997;272:11302-6 pubmed..The direct demonstration of these interactions culminate studies that have inferred an interaction between SecA and SecYEG, and they are consistent with studies suggesting that this region of SecA interacts with the inner membrane. ..
- Pollock D. Contrasting pharmacological ETB receptor blockade with genetic ETB deficiency in renal responses to big ET-1. Physiol Genomics. 2001;6:39-43 pubmed..These experiments indicate that the ET(B) receptor plays an important role in limiting the renal hemodynamic response to big ET-1. Furthermore, the diuretic actions of big ET-1 require a functional ET(B) receptor...
- Bianco N, Montano M. Regulation of prothymosin alpha by estrogen receptor alpha: molecular mechanisms and relevance in estrogen-mediated breast cell growth. Oncogene. 2002;21:5233-44 pubmed..Overall these studies underscore the importance of PTalpha in estrogen-induced breast cell proliferation. ..
- Balasubramanian S, Eckert R. Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. J Biol Chem. 2004;279:24007-14 pubmed..The observation that two antioxidants can produce opposite effects is an important consideration in the context of therapeutic antioxidant use. ..
- Kelley A, Baldo B, Pratt W. A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward. J Comp Neurol. 2005;493:72-85 pubmed
- Ishikawa H, Carrasco D, Claudio E, Ryseck R, Bravo R. Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2. J Exp Med. 1997;186:999-1014 pubmed..Thus, the p100 precursor is essential for the proper regulation of p52-containing Rel/NF-kappaB complexes in various cell types and its absence cannot be efficiently compensated for by other IkappaB proteins. ..
- Samuelson J, Jiang F, Yi L, Chen M, de Gier J, Kuhn A, et al. Function of YidC for the insertion of M13 procoat protein in Escherichia coli: translocation of mutants that show differences in their membrane potential dependence and Sec requirement. J Biol Chem. 2001;276:34847-52 pubmed..These studies are consistent with the understanding that YidC cooperates with the Sec translocase for membrane translocation and that YidC is required for clearing the protein-conducting channel. ..
- Belden W, Barlowe C. Role of Erv29p in collecting soluble secretory proteins into ER-derived transport vesicles. Science. 2001;294:1528-31 pubmed..In vivo, export of gpalphaf from the ER was saturable and depended on the expression level of Erv29p. These results indicate that membrane receptors can link soluble cargo proteins to the COPII coat. ..
- Keegan B, Memoli V, North W. Targeting the neurophysin-related cell surface antigen on small cell lung cancer cells using a monoclonal antibody against the glycopeptide region (MAG-1) of provasopressin. Mol Cancer Ther. 2002;1:1153-9 pubmed..This is the first study to demonstrate that a mAb directed to the VAG region of the pro-VP protein has the potential for development into an in vivo diagnostic and therapeutic tool that targets plasma membrane-incorporated NRSA. ..
- Eghlidi D, Haley G, Noriega N, Kohama S, Urbanski H. Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques. Endocrinology. 2010;151:3783-94 pubmed publisher..Nevertheless, they clearly demonstrate that loss of ovarian steroid negative feedback that occurs during perimenopause plays a major role in modulating the activity of KNDy circuits of the aging primate ARC-ME...
- Gakh O, Bedekovics T, Duncan S, Smith D, Berkholz D, Isaya G. Normal and Friedreich ataxia cells express different isoforms of frataxin with complementary roles in iron-sulfur cluster assembly. J Biol Chem. 2010;285:38486-501 pubmed publisher..We suggest that the levels of both isoforms are relevant to FRDA pathophysiology and that the FXN(81-210)/FXN(42-210) molar ratio should provide a useful parameter to optimize FXN augmentation and replacement therapies...
- Blanchard R, Cousins R. Upregulation of rat intestinal uroguanylin mRNA by dietary zinc restriction. Am J Physiol. 1997;272:G972-8 pubmed..These results also suggest a potential mechanism to explain, at least in part, the beneficial effects of zinc supplementation for secretory diarrhea prevalent in many areas of the world...
- Pearce G, Siems W, Bhattacharya R, Chen Y, Ryan C. Three hydroxyproline-rich glycopeptides derived from a single petunia polyprotein precursor activate defensin I, a pathogen defense response gene. J Biol Chem. 2007;282:17777-84 pubmed..They did, however, activate expression of defensin 1, a gene associated with inducible defense responses against pathogens...
- George E, Brown D. Prothymosin alpha is a component of a linker histone chaperone. FEBS Lett. 2010;584:2833-6 pubmed publisher..These results indicate that ProTalpha is a component of a linker histone chaperone. ..
- Yao J, Buschman L, Oppert B, Khajuria C, Zhu K. Characterization of cDNAs encoding serine proteases and their transcriptional responses to Cry1Ab protoxin in the gut of Ostrinia nubilalis larvae. PLoS ONE. 2012;7:e44090 pubmed publisher..nubilalis larvae and demonstrate differential expression of protease genes that may be related to Cry1Ab intoxication and/or resistance. ..
- Qian J, Yehia G, Molina C, Fernandes A, Donnelly R, Anjaria D, et al. Cloning of human preprotachykinin-I promoter and the role of cyclic adenosine 5'-monophosphate response elements in its expression by IL-1 and stem cell factor. J Immunol. 2001;166:2553-61 pubmed..As PPT-I is implicated in hemopoietic regulation, immune responses, breast cancer, and other neural functions, these studies add to the basic biology of these processes and could provide targets for drug development. ..
- D Alessio D, Kieffer T, Taborsky G, Havel P. Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques. J Clin Endocrinol Metab. 2001;86:1253-9 pubmed..These results indicate that activation of the PNS during the absorptive phase of meals contributes significantly to the postprandial insulin secretory response. ..
- Swaan P, Knoell D, Helsper F, Wewers M. Sequential processing of human ProIL-1beta by caspase-1 and subsequent folding determined by a combined in vitro and in silico approach. Pharm Res. 2001;18:1083-90 pubmed..These findings may facilitate the development of novel pharmacological agents that control posttranslational proIL-1beta modification, thereby preventing excessive production of this potent inflammatory cytokine. ..
- Beattie M, Harrington A, Lee R, Kim J, Boyce S, Longo F, et al. ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron. 2002;36:375-86 pubmed..Together, these data suggest that the role of proNGF is to eliminate damaged cells by activating the apoptotic machinery of p75 after injury. ..
- Tien L, Ho I, Loh H, Ma T. Role of mu-opioid receptor in modulation of preproenkephalin mRNA expression and opioid and dopamine receptor binding in methamphetamine-sensitized mice. J Neurosci Res. 2007;85:673-80 pubmed..5 mg/kg doses of METH and an increase with 10 mg/kg of METH, in mu-OR knockout mice. These findings suggest that the mu-OR is involved in the regulation of METH-induced changes in an endogenous opioid peptide and dopamine receptors. ..
- Zhu L, Brodie C, Balasubramanian S, Eckert R. Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression--a key role of PKCdelta-Y311. J Invest Dermatol. 2008;128:833-45 pubmed..These findings indicate that PKCdelta activity requires Y(311) and a second tyrosine residue; however, any one of the several tyrosine residues can serve in the secondary role. ..
- Schiller D. Pam17 and Tim44 act sequentially in protein import into the mitochondrial matrix. Int J Biochem Cell Biol. 2009;41:2343-9 pubmed publisher..Pam17 is involved in an early stage of protein translocation whereas Tim44 assists in a later step of transport, suggesting that both proteins can cooperate in a complementary manner in protein import. ..
- Purich D. Use of sodium borohydride to detect acyl-phosphate linkages in enzyme reactions. Methods Enzymol. 2002;354:168-77 pubmed
- Zhou A, Minami M, Zhu X, Bae S, Minthorne J, Lan J, et al. Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication. J Cereb Blood Flow Metab. 2004;24:612-22 pubmed..These findings suggest that ischemia has an adverse impact on the neuropeptide-processing system in the brain and that the lack of an active neuropeptide-processing enzyme exacerbates ischemic brain injury. ..
- Crish J, Gopalakrishnan R, Bone F, Gilliam A, Eckert R. The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vivo involucrin expression. J Invest Dermatol. 2006;126:305-14 pubmed..These studies suggest that AP1, Sp1, and C/EBP transcription factors are required for appropriate differentiation-dependent involucrin expression, and that the mechanism of regulation is similar in most surface epithelia. ..
- Schiltz C, Bremer Q, Landry C, Kelley A. Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression. BMC Biol. 2007;5:16 pubmed..As many of these genes play a role in plasticity, their upregulation within these circuits may also indicate the neuroanatomic and transcriptional correlates of extinction learning. ..
- Ristic Z, Momcilovic I, Fu J, Callegari E, DeRidder B. Chloroplast protein synthesis elongation factor, EF-Tu, reduces thermal aggregation of rubisco activase. J Plant Physiol. 2007;164:1564-71 pubmed..The results are consistent with the hypothesis that chloroplast EF-Tu plays a functional role in heat tolerance by acting as a molecular chaperone. ..
- Hasan W, Smith P. Modulation of rat parasympathetic cardiac ganglion phenotype and NGF synthesis by adrenergic nerves. Auton Neurosci. 2009;145:17-26 pubmed publisher..Because chemical blockade of all noradrenergic transmission is no more effective than extrinsic sympathectomy, local intrinsic noradrenergic transmission is not a factor in regulating ganglion neuron phenotype. ..
- Ma X, Cline K. Multiple precursor proteins bind individual Tat receptor complexes and are collectively transported. EMBO J. 2010;29:1477-88 pubmed publisher..These results imply a novel aspect of Tat systems, whereby multiple precursor-binding sites can act in concert to transport an interlinked oligo-precursor protein...
- Woodbury R, Topping T, Diamond D, Suciu D, Kumamoto C, Hardy S, et al. Complexes between protein export chaperone SecB and SecA. Evidence for separate sites on SecA providing binding energy and regulatory interactions. J Biol Chem. 2000;275:24191-8 pubmed..The region of SecA involved in activation of the complexes was defined as the extreme carboxyl-terminal 21 aminoacyl residues. ..
- Woodbury R, Hardy S, Randall L. Complex behavior in solution of homodimeric SecA. Protein Sci. 2002;11:875-82 pubmed
- Pearton D, Dale B, Presland R. Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution. J Invest Dermatol. 2002;119:661-9 pubmed
- Ball S, Bardenstein D, Alagramam K. Assessment of retinal structure and function in Ames waltzer mice. Invest Ophthalmol Vis Sci. 2003;44:3986-92 pubmed..The explanation for the absence of retinal phenotype in the Ames mouse should be helpful in understanding USH1F and developing treatments for this disorder. ..
- Tseung C, McMahon L, Vazquez J, Pohl J, Gregory J. Partial amino acid sequence and mRNA analysis of cytosolic pyridoxine-beta-D-glucoside hydrolase from porcine intestinal mucosa: proposed derivation from the lactase-phlorizin hydrolase gene. Biochem J. 2004;380:211-8 pubmed..Based on these observations, we propose that both PNGH and LPH enzymes have the same genomic origin, but differ in transcriptional and, possibly, post-translational processing. ..
- Pal S, Nemeth M, Bodine D, Miller J, Svaren J, Thein S, et al. Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1. J Biol Chem. 2004;279:31348-56 pubmed..Since NK-B induced cAMP accumulation in yolk sac endothelial cells, these results suggest a new mode of vascular regulation in which GATA-1 controls NK-B synthesis in erythroid cells. ..
- Eckert R, Crish J, Efimova T, Dashti S, Deucher A, Bone F, et al. Regulation of involucrin gene expression. J Invest Dermatol. 2004;123:13-22 pubmed
- Karla A, Lively M, Paetzel M, Dalbey R. The identification of residues that control signal peptidase cleavage fidelity and substrate specificity. J Biol Chem. 2005;280:6731-41 pubmed..This work shows that Ile-144 and Ile-86 contribute to the signal peptidase substrate specificity and that Ile-144 is important for the accuracy of the cleavage reaction. ..
- Celebi N, Yi L, Facey S, Kuhn A, Dalbey R. Membrane biogenesis of subunit II of cytochrome bo oxidase: contrasting requirements for insertion of N-terminal and C-terminal domains. J Mol Biol. 2006;357:1428-36 pubmed
- Haywood Watson R, Ahmed Z, Kjellstrom S, Bush R, Takada Y, Hampton L, et al. Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts. Invest Ophthalmol Vis Sci. 2006;47:3074-84 pubmed..Understanding the molecular mechanism by which av mice circumvent degeneration of the retina might offer insights into potential therapies for USH1. ..
- Yeh Y, Lin C, Chen T. Human IGF-I Eb-peptide induces cell attachment and lamellipodia outspread of metastatic breast carcinoma cells (MDA-MB-231). Exp Cell Res. 2017;358:199-208 pubmed publisher..With the highly purified hEb-peptide, not only could we study its function(s) in detail but also the minimum requirement for cancerous cells to metastasize to a suitable environment and grow. ..
- Duong F, Wickner W. Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme. EMBO J. 1997;16:2756-68 pubmed..Our findings show that each of the prokaryote-specific subunits (SecA, SecG and SecDFyajC) function together to promote preprotein movement at the SecYE core of the translocase. ..
- Banks E, Crish J, Welter J, Eckert R. Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites. Biochem J. 1998;331 ( Pt 1):61-8 pubmed
- White S, May V, Braas K. Organization of the rat PACAP gene. Ann N Y Acad Sci. 2000;921:370-2 pubmed..Analysis of PACAP promoter activity in PC12 cells suggests that forskolin responsiveness of the gene is dependent on elements located between -77 and -413 bp from the transcription start site. ..
- Xu J, Cho H, O MALLEY S, Park J, Clarke S. Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms. J Nutr. 2002;132:3333-9 pubmed..These data indicate that PUFA suppress the in vivo proteolytic release of SREBP-1 and -2, but the effect on SREBP-2 is transitory, possibly reflecting the ability of PUFA to enhance cholesterol losses via bile acid synthesis. ..