Experts and Doctors on protein isoforms in Germany


Locale: Germany
Topic: protein isoforms

Top Publications

  1. Meissner W, Thomae R, Seifart K. The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells. J Biol Chem. 2002;277:7148-56 pubmed
    ..The partial purification of pol III transcription factors from PE and EC cells revealed that TFIIIC2 activity could be purified from both cell types, whereas TFIIIC1 activity was dramatically reduced in extracts from PE cells. ..
  2. Makarenko I, Opitz C, Leake M, Neagoe C, Kulke M, Gwathmey J, et al. Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts. Circ Res. 2004;95:708-16 pubmed
    ..The titin-isoform shift may be beneficial for myocardial diastolic function, but could impair the contractile performance in systole. ..
  3. Hettmann C, Herm A, Geiter A, Frank B, Schwarz E, Soldati T, et al. A dibasic motif in the tail of a class XIV apicomplexan myosin is an essential determinant of plasma membrane localization. Mol Biol Cell. 2000;11:1385-400 pubmed
    ..We discuss the evidence for a proteinaceous plasma membrane receptor and the implications for the invasion process. ..
  4. Morano I, Chai G, Baltas L, Lamounier Zepter V, Lutsch G, Kott M, et al. Smooth-muscle contraction without smooth-muscle myosin. Nat Cell Biol. 2000;2:371-5 pubmed
    ..We conclude that phase 1 becomes indispensable for survival and normal growth soon after birth, particularly for functions such as homeostasis and circulation. ..
  5. Hartung F, Puchta H. Molecular characterization of homologues of both subunits A (SPO11) and B of the archaebacterial topoisomerase 6 in plants. Gene. 2001;271:81-6 pubmed
    ..Our data suggest that plants possess in contrast to other eukaryotes an additional archaebacterial kind of topoisomerase. ..
  6. Oh C, Aho H, Shamsadin R, Nayernia K, Muller C, Sancken U, et al. Characterization, expression pattern and chromosomal localization of the spermatogenesis associated 6 gene (Spata6). Mol Hum Reprod. 2003;9:321-30 pubmed
  7. Büttner B, Kannicht C, Reutter W, Horstkorte R. The neural cell adhesion molecule is associated with major components of the cytoskeleton. Biochem Biophys Res Commun. 2003;310:967-71 pubmed
    ..Furthermore, we demonstrate that inhibition of rhoA-binding kinase-alpha stimulates neurite outgrowth independently from NCAM. ..
  8. Zanner R, Gratzl M, Prinz C. Expression of the endocytic proteins dynamin and amphiphysin in rat gastric enterochromaffin-like cells. J Cell Sci. 2004;117:2369-76 pubmed
    ..To our knowledge, this is the first demonstration of the co-expression of all three dynamin isoforms in a non-tumor cell. ..
  9. Heider I, Schulze B, Oswald E, Henklein P, Scheele J, Kaufmann R. PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism. Oncol Res. 2004;14:475-82 pubmed
    ..Therefore, PAR1 seems to be the responsible receptor for thrombin-induced migration and adhesion of human colon carcinoma cells including PKCepsilon as an essential signal transducer. ..

More Information

Publications478 found, 100 shown here

  1. Knippschild U, Wolff S, Giamas G, Brockschmidt C, Wittau M, Würl P, et al. The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie. 2005;28:508-14 pubmed
    ..In this review, we summarize the functions of CK1 and outline the participation of CK1 in signal transduction pathways linked to cancer development. ..
  2. Strutz Seebohm N, Seebohm G, Fedorenko O, Baltaev R, Engel J, Knirsch M, et al. Functional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytes. Cell Physiol Biochem. 2006;18:57-66 pubmed
    ..In conclusion, KCNEs are presumably coexpressed with KCNQ4 in hair cells from the organ of Corti and might regulate KCNQ4 functional properties, effects that could be important under physiological and pathophysiological conditions. ..
  3. Liedtke T, Schwamborn J, Schröer U, Thanos S. Elongation of axons during regeneration involves retinal crystallin beta b2 (crybb2). Mol Cell Proteomics. 2007;6:895-907 pubmed
    ..The results suggest that neuronal crystallins constitute a novel class of neurite-promoting factors that likely operate through an autocrine mechanism and that they could be used in neurodegenerative diseases. ..
  4. Neitz A, Mergia E, Eysel U, Koesling D, Mittmann T. Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Eur J Neurosci. 2011;33:1611-21 pubmed publisher
    ..In summary, we unravel a presynaptic role of NO/cGMP most likely in glutamate release and propose that HCN channels act as effectors for cGMP. ..
  5. Chua J, Schob C, Rehbein M, Gkogkas C, Richter D, Kindler S. Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via alternative translational initiation. Sci Rep. 2012;2:484 pubmed publisher
    ..Thus, alternative translation initiation events appear to regulate relative expression of distinct SAPAP3 isoforms in different brain regions, which may function to influence synaptic plasticity. ..
  6. Kirschner R, Rosenberg T, Schultz Heienbrok R, Lenzner S, Feil S, Roepman R, et al. RPGR transcription studies in mouse and human tissues reveal a retina-specific isoform that is disrupted in a patient with X-linked retinitis pigmentosa. Hum Mol Genet. 1999;8:1571-8 pubmed
    ..Our results indicate tissue-dependent regulation of alternative splicing of RPGR in mouse and man. The discovery of a retina-specific transcript may explain why phenotypic abberations in RP3 are confined to the eye. ..
  7. Grothe C, Nikkhah G. The role of basic fibroblast growth factor in peripheral nerve regeneration. Anat Embryol (Berl). 2001;204:171-7 pubmed
    ..Thus, basic fibroblast growth factor could be a promising candidate to contribute to the development of new therapeutic strategies for the treatment of peripheral nerve injuries. ..
  8. Kohler M, Buchwalow I, Alexander G, Christiansen M, Shagdarsuren E, Samoilova V, et al. Increased importin alpha protein expression in diabetic nephropathy. Kidney Int. 2001;60:2263-73 pubmed
    ..The signaling pathways appear differentially regulated in glomeruli, proximal, and distal tubules. The enhanced nuclear transport may participate in increased gene expression and nephrosclerosis in diabetes. ..
  9. Grimm Günter E, Milbrandt M, Merkl B, Paulsson M, Plomann M. PACSIN proteins bind tubulin and promote microtubule assembly. Exp Cell Res. 2008;314:1991-2003 pubmed publisher
    ..These findings suggest a novel function for PACSIN proteins in dynamic microtubuli nucleation. ..
  10. Budt M, Michely B, Müller M, Reutter W, Lucka L. Secreted CEACAM1 splice variants in rat cell lines and in vivo in rat serum. Biochem Biophys Res Commun. 2002;292:749-55 pubmed
    ..Functionally, soluble CEACAM1 could inhibit CEACAM1-mediated aggregation of CHO cells. In conclusion, our data define a new mechanism for the appearance of functionally active rat CEACAM1 protein in body fluids. ..
  11. Hochstrasser H, Tomiuk J, Walter U, Behnke S, Spiegel J, Kruger R, et al. Functional relevance of ceruloplasmin mutations in Parkinson's disease. FASEB J. 2005;19:1851-3 pubmed
    ..Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD. ..
  12. Vishnu S, Hertenstein A, Betschinger J, Knoblich J, Gert de Couet H, Fischbach K. The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila. Dev Biol. 2006;289:296-307 pubmed
    ..Using genetic, cell biological, and biochemical approaches, we show that the interaction of Rst with X11Lalpha is of biological significance. The proteins interact, for example, in the context of cell sorting in the pupal retina. ..
  13. Herbrand U, Ahmadian M. p190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho. Biol Chem. 2006;387:311-7 pubmed
    ..This process is mediated by Rac1, but not by Rac2 or Rac3 isoforms. Our data provide evidence for a biochemical pathway of the reciprocal regulation of two related small GTPases, which are key elements in cell migration. ..
  14. Moritz S, Lehmann S, Faissner A, von Holst A. An induction gene trap screen in neural stem cells reveals an instructive function of the niche and identifies the splicing regulator sam68 as a tenascin-C-regulated target gene. Stem Cells. 2008;26:2321-31 pubmed publisher
    ..This emphasizes the importance of Sam68 for NSC biology and implicates an instructive rather than a purely permissive role for Tnc in the neural stem cell niche. ..
  15. Wanka H, Staar D, Lutze P, Peters B, Hildebrandt J, Beck T, et al. Anti-necrotic and cardioprotective effects of a cytosolic renin isoform under ischemia-related conditions. J Mol Med (Berl). 2016;94:61-9 pubmed publisher
    ..The protective effects of cytosolic renin contradict the known function of secretory renin. The effects of cytosolic renin are not mediated via angiotensin generation. Renin-binding protein is a potential target for cytosolic renin. ..
  16. Ciossek T, Ullrich A, West E, Rogers J. Segregation of the receptor EphA7 from its tyrosine kinase-negative isoform on neurons in adult mouse brain. Brain Res Mol Brain Res. 1999;74:231-6 pubmed
    ..This suggests that the TK- receptor, acting as a dominant negative antagonist, may ensure that the TK+ receptor only responds to signals encountered by the growing extremities of axons or dendrites. ..
  17. Schonherr E, Schaefer L, O Connell B, Kresse H. Matrix metalloproteinase expression by endothelial cells in collagen lattices changes during co-culture with fibroblasts and upon induction of decorin expression. J Cell Physiol. 2001;187:37-47 pubmed
    ..hy 926 cells for a finely tuned induction of selected MMPs which are involved in angiogenesis whereas the up-regulation of MMPs does not lead to the degradation of the responsible proteoglycan. ..
  18. Hagemann D, Bohlender J, Hoch B, Krause E, Karczewski P. Expression of Ca2+/calmodulin-dependent protein kinase II delta-subunit isoforms in rats with hypertensive cardiac hypertrophy. Mol Cell Biochem. 2001;220:69-76 pubmed
    ..The observed alterations of CaMKIIdelta isoform patterns may affect intracellular Ca2+ homeostasis and thus contribute to the abnormal contractile phenotype of cardiac hypertrophy. ..
  19. Langhans M, Ratajczak R, Lützelschwab M, Michalke W, Wachter R, Fischer Schliebs E, et al. Immunolocalization of plasma-membrane H+-ATPase and tonoplast-type pyrophosphatase in the plasma membrane of the sieve element-companion cell complex in the stem of Ricinus communis L. Planta. 2001;213:11-9 pubmed
    ..The function of the PPase could be related to phloem sucrose metabolism in support of ATP-requiring processes...
  20. Métivier R, Stark A, Flouriot G, Hübner M, Brand H, Penot G, et al. A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains. Mol Cell. 2002;10:1019-32 pubmed
    ..This model gives insights into the dynamic properties of full-length ERalpha and into the structure of unliganded ERalpha. ..
  21. Kassel O, Schneider S, Heilbock C, Litfin M, Göttlicher M, Herrlich P. A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters. Genes Dev. 2004;18:2518-28 pubmed
  22. Wruck C, Funke Kaiser H, Pufe T, Kusserow H, Menk M, Schefe J, et al. Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein. Arterioscler Thromb Vasc Biol. 2005;25:57-64 pubmed
    ..Our results indicate that ATBP50 regulates the transport of the AT2R to cell membrane by binding to a specific motif within its cytoplasmic carboxy-terminal and thereby enabling the antiproliferative effects of the receptor. ..
  23. Kloss S, Rodenbach D, Bordel R, Mülsch A. Human-antigen R (HuR) expression in hypertension: downregulation of the mRNA stabilizing protein HuR in genetic hypertension. Hypertension. 2005;45:1200-6 pubmed
    ..These findings suggest that in this animal model of genetic hypertension, the reduced expression of sGC subunits is mediated by downregulation of the sGC mRNA-stabilizing protein HuR. ..
  24. Elfrink K, Nagel Steger L, Riesner D. Interaction of the cellular prion protein with raft-like lipid membranes. Biol Chem. 2007;388:79-89 pubmed
    ..This corresponds to a free energy of the insertion reaction of -48 kJ/mol. Consequences for the conversion of PrP(C) to PrP(Sc) are discussed. ..
  25. Gohla A, Klement K, Piekorz R, Pexa K, vom Dahl S, Spicher K, et al. An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver. Proc Natl Acad Sci U S A. 2007;104:3003-8 pubmed
    ..These data indicate that Galpha(i3) is crucial for the antiautophagic action of insulin and suggest an as-yet-unrecognized function for Galpha(i3) on autophagosomal membranes. ..
  26. Zick M, Duvezin Caubet S, Schäfer A, Vogel F, Neupert W, Reichert A. Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion. FEBS Lett. 2009;583:2237-43 pubmed publisher
    ..A functional GTPase domain is required only in s-Mgm1 but not in l-Mgm1. We propose that l-Mgm1 acts primarily as an anchor in the inner membrane that in concert with the GTPase activity of s-Mgm1 mediates the fusion of inner membranes. ..
  27. Bollacke A, Nienberg C, Borgne M, Jose J. Toward selective CK2alpha and CK2alpha' inhibitors: Development of a novel whole-cell kinase assay by Autodisplay of catalytic CK2alpha'. J Pharm Biomed Anal. 2016;121:253-260 pubmed publisher
    ..A set of twelve ATP competitive CK2 inhibitors with an indeno[1,2-b]indole scaffold was tested in order to demonstrate suitability for this application. ..
  28. Pette D. The adaptive potential of skeletal muscle fibers. Can J Appl Physiol. 2002;27:423-48 pubmed
    ..The maximum range of possible transitions in either direction depends on the fiber phenotype and is determined by its initial location in the fiber spectrum. ..
  29. Leshchyns ka I, Sytnyk V, Morrow J, Schachner M. Neural cell adhesion molecule (NCAM) association with PKCbeta2 via betaI spectrin is implicated in NCAM-mediated neurite outgrowth. J Cell Biol. 2003;161:625-39 pubmed
    ..Furthermore, transfection with betaI2-3 inhibits NCAM-induced neurite outgrowth, showing that formation of the NCAM-spectrin-PKCbeta2 complex is necessary for NCAM-mediated neurite outgrowth. ..
  30. Beissbarth T, Borisevich I, Hörlein A, Kenzelmann M, Hergenhahn M, Klewe Nebenius A, et al. Analysis of CREM-dependent gene expression during mouse spermatogenesis. Mol Cell Endocrinol. 2003;212:29-39 pubmed
  31. Gabler M, Volkmar M, Weinlich S, Herbst A, Dobberthien P, Sklarss S, et al. Trans-splicing of the mod(mdg4) complex locus is conserved between the distantly related species Drosophila melanogaster and D. virilis. Genetics. 2005;169:723-36 pubmed publisher
    ..virilis mod(mdg4) transgenes to rescue recessive lethality of mod(mdg4) mutant alleles in D. melanogaster...
  32. Nitz I, Döring F, Schrezenmeir J, Burwinkel B. Identification of new acyl-CoA binding protein transcripts in human and mouse. Int J Biochem Cell Biol. 2005;37:2395-405 pubmed
    ..Given the fact that the new variant is highly expressed in adipose tissue and a PPARgamma target, it might be relevant for diseases like diabetes and obesity. ..
  33. Skiba M, Mettenleiter T, Karger A. Quantitative whole-cell proteome analysis of pseudorabies virus-infected cells. J Virol. 2008;82:9689-99 pubmed publisher
    ..As a common pattern for all these proteins, a mass shift in favor of the more acidic isoforms was observed, suggesting the involvement of viral or cellular kinases...
  34. Nissum M, Abu Shehab M, Sukop U, Khosravi J, Wildgruber R, Eckerskorn C, et al. Functional and complementary phosphorylation state attributes of human insulin-like growth factor-binding protein-1 (IGFBP-1) isoforms resolved by free flow electrophoresis. Mol Cell Proteomics. 2009;8:1424-35 pubmed publisher
    ..This overall strategy will also be broadly applicable to other phosphoproteins with clinical and functional significance. ..
  35. Schlenz H, Kummer W, Jositsch G, Wess J, Krasteva G. Muscarinic receptor-mediated bronchoconstriction is coupled to caveolae in murine airways. Am J Physiol Lung Cell Mol Physiol. 2010;298:L626-36 pubmed publisher
    ..Here, we demonstrated that M2R- and M3R-mediated bronchoconstriction is caveolae-dependent. Since caveolin-3 is directly associated with M2R, we suggest caveolin-3 as novel regulator of M2R-mediated signaling. ..
  36. Almasalmeh A, Krenc D, Wu B, Beitz E. Structural determinants of the hydrogen peroxide permeability of aquaporins. FEBS J. 2014;281:647-56 pubmed publisher
    ..Thus, generally, AQPs must be considered as putative players in situations of oxidative stress (e.g. in Plasmodium-infected red blood cells, immune cells, the cardiovascular system or cells expressing AQP8 in their mitochondria)...
  37. Qiu F, Lakey A, Agianian B, Hutchings A, Butcher G, Labeit S, et al. Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect. Biochem J. 2003;371:811-21 pubmed
    ..We suggest that initial activation of IFM is by Ca(2+) binding to troponin with the two-site TnC, and full activation is through the action of stretch on the complex with the one-site isoform. ..
  38. Bojunga J, Dresar Mayert B, Usadel K, Kusterer K, Zeuzem S. Antioxidative treatment reverses imbalances of nitric oxide synthase isoform expression and attenuates tissue-cGMP activation in diabetic rats. Biochem Biophys Res Commun. 2004;316:771-80 pubmed
    ..Furthermore, our data show that antioxidative treatment is capable of reversing changes in the NO-cGMP system and may therefore be an important therapeutic option for preventing vascular damage in diabetes mellitus. ..
  39. Baek M, Weiss M. Down-regulation of Na+ pump alpha 2 isoform in isoprenaline-induced cardiac hypertrophy in rat: evidence for increased receptor binding affinity but reduced inotropic potency of digoxin. J Pharmacol Exp Ther. 2005;313:731-9 pubmed
    ..Coadministration of KB-R7943 significantly reduced cellular response generation at higher digoxin doses to the same limiting stimulus-response relationship in both the vehicle and isoprenaline group. ..
  40. Geserick P, Hupe M, Moulin M, Wong W, Feoktistova M, Kellert B, et al. Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol. 2009;187:1037-54 pubmed publisher
    ..These results demonstrate a fundamental role for RIP1 in CD95 signaling and provide support for a physiological role of caspase-independent death receptor-mediated cell death. ..
  41. Monshausen M, Putz U, Rehbein M, Schweizer M, DesGroseillers L, Kuhl D, et al. Two rat brain staufen isoforms differentially bind RNA. J Neurochem. 2001;76:155-65 pubmed
    ..Thus in neurones, rat Staufen may serve to link RNAs to the dendritic microtubular cytoskeleton and may thereby regulate their subcellular localization. ..
  42. Krüger O, Ladewig J, Köster K, Ragg H. Widespread occurrence of serpin genes with multiple reactive centre-containing exon cassettes in insects and nematodes. Gene. 2002;293:97-105 pubmed
    ..The occurrence of such serpin genes in some groups of metazoa reflects a parsimonious way to enlarge the adaptive ability of these organisms to cope with a plethora of different serine and cysteine proteases. ..
  43. Ebert J, Zelenka M, Gath I, Gödtel Armbrust U, Förstermann U. Colocalization but differential regulation of neuronal NO synthase and nicotinic acetylcholine receptor in C2C12 myotubes. Am J Physiol Cell Physiol. 2003;284:C1065-72 pubmed
    ..These data demonstrate that nNOS and the nAChR are colocalized in murine skeletal muscle and C(2)C(12) cells but differ in their expressional regulation...
  44. Speidel D, Varoqueaux F, Enk C, Nojiri M, Grishanin R, Martin T, et al. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. J Biol Chem. 2003;278:52802-9 pubmed
    ..The abundance of CAPS proteins in synaptic terminals indicates that they may also be important for neuronal functions that are not exclusively related to LDCV exocytosis. ..
  45. Ulzheimer J, Peles E, Levinson S, Martini R. Altered expression of ion channel isoforms at the node of Ranvier in P0-deficient myelin mutants. Mol Cell Neurosci. 2004;25:83-94 pubmed
    ..Thus, deficiency of P0 leads to dysregulation of nodal VGSC isoforms and to altered localization of paranodal and juxtaparanodal components of the nodal complex. ..
  46. Herlan M, Bornhovd C, Hell K, Neupert W, Reichert A. Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. J Cell Biol. 2004;165:167-73 pubmed
    ..Through this process the mitochondrial ATP level might control mitochondrial morphology. ..
  47. Hegener O, Prenner L, Runkel F, Baader S, Kappler J, Häberlein H. Dynamics of beta2-adrenergic receptor-ligand complexes on living cells. Biochemistry. 2004;43:6190-9 pubmed
    ..This regulatory receptor internalization was blocked after preincubation with propranolol and with a cholesterol-complexing saponin alpha-hederin. ..
  48. Scheepers A, Joost H, Schurmann A. The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J Parenter Enteral Nutr. 2004;28:364-71 pubmed
    ..In addition, a malfunction of glucose transporter expression or regulation (GLUT4) appears to contribute to the insulin resistance syndrome. ..
  49. Schumacher V, Jeruschke S, Eitner F, Becker J, Pitschke G, Ince Y, et al. Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome. J Am Soc Nephrol. 2007;18:719-29 pubmed
    ..The alteration in VEGF-A expression presented here may provide a mechanistic insight into the pathogenesis of DDS. ..
  50. Rey Ares V, Lazarov N, Berg D, Berg U, Kunz L, Mayerhofer A. Dopamine receptor repertoire of human granulosa cells. Reprod Biol Endocrinol. 2007;5:40 pubmed
    ..This suggests a complex role of DA in the regulation of ovarian processes. ..
  51. Arndt T, van der Meijden B, Wielders J. Atypical serum transferrin isoform distribution in liver cirrhosis studied by HPLC, capillary electrophoresis and transferrin genotyping. Clin Chim Acta. 2008;394:42-6 pubmed publisher
    ..Although further studies are needed to assess the relationship between this phenomenon and liver cirrhosis, our observation could be helpful in development of a biomarker for liver cirrhosis. ..
  52. Richters L, Lange N, Renner R, Treiber N, Ghanem A, Tiemann K, et al. Exercise-induced adaptations of cardiac redox homeostasis and remodeling in heterozygous SOD2-knockout mice. J Appl Physiol (1985). 2011;111:1431-40 pubmed publisher
    ..In conclusion, downregulation of SOD2 induces a maladaptive cardiac hypertrophy. In this situation, physical exercise results in a further deterioration of cardiac remodeling despite an upregulation of the antioxidative defense system. ..
  53. Koch H, Hofmann K, Brose N. Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform. Biochem J. 2000;349:247-53 pubmed
    ..The MHD profiles described in the present study are useful tools for the identification of Munc13-like proteins, that would otherwise have remained undetected. ..
  54. Mayerhofer P, Kattenfeld T, Roscher A, Muntau A. Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly. Biochem Biophys Res Commun. 2002;291:1180-6 pubmed
  55. von Groote Bidlingmaier F, Schmoll D, Orth H, Joost H, Becker W, Barthel A. DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Biochem Biophys Res Commun. 2003;300:764-9 pubmed
    ..In summary, the data suggest that DYRK1 is a specific co-activator of FKHR, independent of its kinase activity. ..
  56. Harborth J, Elbashir S, Vandenburgh K, Manninga H, Scaringe S, Weber K, et al. Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev. 2003;13:83-105 pubmed
  57. Lupp A, Danz M, Muller D. Evaluation of 2-year-old intrasplenic fetal liver tissue transplants in rats. Cell Transplant. 2003;12:423-38 pubmed
    ..This may be due either to the protection of these transplants by the orthotopic livers or to the different humoral and nerval influences at the ectopic site. ..
  58. Lieb B, Boisgu rin V, Gebauer W, Markl J. cDNA sequence, protein structure, and evolution of the single hemocyanin from Aplysia californica, an opisthobranch gastropod. J Mol Evol. 2004;59:536-45 pubmed publisher
    ..However, the gene duplication yielding the two distinct hemocyanin isoforms found today in Haliotis tuberculata occurred 343+/-43 million years ago...
  59. Wahl Schott C, Baumann L, Zong X, Biel M. An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels. J Biol Chem. 2005;280:13694-700 pubmed
    ..Our data indicate that Arg-405 is a key component of a domain that allosterically couples Cl- binding with channel activation. ..
  60. Z rb C, Noll A, Karl S, Leib K, Yan F, Schubert S. Molecular characterization of Na+/H+ antiporters (ZmNHX) of maize (Zea mays L.) and their expression under salt stress. J Plant Physiol. 2005;162:55-66 pubmed publisher
    ..No salt response of ZmNHX was detected for maize F1 hybrid Pioneer 3906 with moderate Na+ exclusion. The relationship of the expression of ZmNHX with salt resistance of maize is discussed...
  61. Vatter P, Stoesser C, Samel I, Gierschik P, Moepps B. The variable C-terminal extension of G-protein-coupled receptor kinase 6 constitutes an accessorial autoregulatory domain. FEBS J. 2005;272:6039-51 pubmed
  62. Iorga B, Adamek N, Geeves M. The slow skeletal muscle isoform of myosin shows kinetic features common to smooth and non-muscle myosins. J Biol Chem. 2007;282:3559-70 pubmed
    ..The role of these actin-myosin.ADP complexes in the mechanochemistry of slow muscle contraction is discussed in relation to the load dependence of ADP release...
  63. Kuehn C, Weikard R. Multiple splice variants within the bovine silver homologue (SILV) gene affecting coat color in cattle indicate a function additional to fibril formation in melanophores. BMC Genomics. 2007;8:335 pubmed
  64. Quasdorff M, Hösel M, Odenthal M, Zedler U, Bohne F, Gripon P, et al. A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation. Cell Microbiol. 2008;10:1478-90 pubmed publisher
    ..Thus, a concerted action of HNF4alpha and HNF1alpha, which also determines morphological and functional differentiation of hepatocytes, links HBV replication to hepatocyte differentiation. ..
  65. Ul Hussain M, Zoidl G, Klooster J, Kamermans M, Dermietzel R. IRES-mediated translation of the carboxy-terminal domain of the horizontal cell specific connexin Cx55.5 in vivo and in vitro. BMC Mol Biol. 2008;9:52 pubmed publisher
    ..This suggests that Cx55.5 could be involved in gene regulation making structural plasticity at the PRC/HC/BPC complex feasible. ..
  66. Ueffing N, Singh K, Christians A, Thorns C, Feller A, Nagl F, et al. A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein. Blood. 2009;114:572-9 pubmed publisher
    ..A comparison of 183 patients with follicular lymphoma and 233 population controls revealed an increased lymphoma risk associated with the rs10190751 A genotype causing c-FLIP(R) expression. ..
  67. Nothmann D, Leinenweber A, Torres Salazar D, Kovermann P, Hotzy J, Gameiro A, et al. Hetero-oligomerization of neuronal glutamate transporters. J Biol Chem. 2011;286:3935-43 pubmed publisher
    ..Our results demonstrate the existence of heterotrimeric glutamate transporters and provide novel information about the physiological impact of EAAT oligomerization. ..
  68. Kirchhof P, Kahr P, Kaese S, Piccini I, Vokshi I, Scheld H, et al. PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression. Circ Cardiovasc Genet. 2011;4:123-33 pubmed publisher
    ..These findings demonstrate a physiological role for PITX2 in the adult heart and support the hypothesis that dysregulation of PITX2 expression can be responsible for susceptibility to AF. ..
  69. Nordmann A, Wixler L, Boergeling Y, Wixler V, Ludwig S. A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication. FASEB J. 2012;26:1290-300 pubmed publisher
    ..Furthermore, we showed that hGBP-3?C strongly represses the activity of the viral polymerase complex, which results in decreased synthesis of viral vRNA, cRNA, mRNA, and viral proteins, as well. ..
  70. Johnson K, Makanji Y, Temple Smith P, Kelly E, Barton P, Al Musawi S, et al. Biological activity and in vivo half-life of pro-activin A in male rats. Mol Cell Endocrinol. 2016;422:84-92 pubmed publisher
    ..Increased serum half-life of activin A in the presence of its prodomain identifies a new means to increase the therapeutic effectiveness of TGF-β proteins. ..
  71. Waibler Z, Schafer A, Starzinski Powitz A. mARVCF cellular localisation and binding to cadherins is influenced by the cellular context but not by alternative splicing. J Cell Sci. 2001;114:3873-84 pubmed
    ..Our results suggest that the subcellular localisation of mARVCF may be determined not only by the presence or absence of an appropriate interaction partner, in this case cadherins, but also by the cellular context. ..
  72. Wickert L, Steinkrüger S, Abiaka M, Bolkenius U, Purps O, Schnabel C, et al. Quantitative monitoring of the mRNA expression pattern of the TGF-beta-isoforms (beta 1, beta 2, beta 3) during transdifferentiation of hepatic stellate cells using a newly developed real-time SYBR Green PCR. Biochem Biophys Res Commun. 2002;295:330-5 pubmed
    ..Furthermore, the GAPDH mRNA expression varied during HSC activation, and thus is not recommended as a standard in real-time PCR quantifications. ..
  73. Laemmle B, Schindler M, Beilmann M, Hamilton B, Doods H, Wieland H. Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus. Regul Pept. 2003;111:21-9 pubmed
    ..However, hypothalamic NPGPR mRNA was unchanged in both models. Therefore, our evidence does not support the hypothesis that NPGPR is involved in feeding regulation. ..
  74. Gründker C, Emons G. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003;1:65 pubmed
    ..These data suggest that in ovarian cancer cells the antiproliferative effects of GnRH-I antagonist Cetrorelix and GnRH-II are not mediated through the GnRH-I receptor. ..
  75. Bauer N, Richter Landsberg C. The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress. J Mol Neurosci. 2006;29:153-68 pubmed
    ..Furthermore, the binding of stress-induced alphaBcrystallin to the MTs points to a possible protective role during disease progression. ..
  76. Beyer U, Moll Rocek J, Moll U, Dobbelstein M. Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes. Proc Natl Acad Sci U S A. 2011;108:3624-9 pubmed publisher
    ..By providing increased germ-line stability, this event may have contributed to the evolution of hominids and enabled their long reproductive periods...
  77. Pudelski B, Schock A, Hoth S, Radchuk R, Weber H, Hofmann J, et al. The plastid outer envelope protein OEP16 affects metabolic fluxes during ABA-controlled seed development and germination. J Exp Bot. 2012;63:1919-36 pubmed publisher
    ..It is thus concluded that in vivo OEP16 most probably functions in shuttling amino acids across the outer envelope of seed plastids. ..
  78. Buettner R, Papoutsoglou G, Scemes E, Spray D, Dermietzel R. Evidence for secretory pathway localization of a voltage-dependent anion channel isoform. Proc Natl Acad Sci U S A. 2000;97:3201-6 pubmed
    ..Thus, our data provide unique genetic evidence in favor of a multitopological localization of a mitochondrial porin. ..
  79. Löffler S, Aust G, Kohler U, Spanel Borowski K. Evidence of leptin expression in normal and polycystic human ovaries. Mol Hum Reprod. 2001;7:1143-9 pubmed
    ..1-B219.3 was identified in granulosa cells and the CL, as well as in the cortex and medulla. We conclude that leptin is produced in the ovary and may act in autocrine and paracrine ways. ..
  80. Zechel C. Synthetic retinoids dissociate coactivator binding from corepressor release. J Recept Signal Transduct Res. 2002;22:31-61 pubmed
    ..Moreover, this retinoid discriminates between the nuclear corepressors SMRT and NCoR, since it efficiently dissociates SMRT but not NCoR from the RARalpha LBD. ..
  81. Hambrock H, Kaufmann B, Muller S, Hanisch F, Nose K, Paulsson M, et al. Structural characterization of TSC-36/Flik: analysis of two charge isoforms. J Biol Chem. 2004;279:11727-35 pubmed
    ..The lack of conservation of important functional features common to several other members of the BM-40 family indicates that TSC-36, despite its sequence homology to BM-40, has evolved clearly distinct properties. ..
  82. Frey S, Nagl B, Henze A, Raila J, Schlosser B, Berg T, et al. Isoforms of retinol binding protein 4 (RBP4) are increased in chronic diseases of the kidney but not of the liver. Lipids Health Dis. 2008;7:29 pubmed publisher
    ..The occurrence of RBP4 isoforms is not influenced by liver function but seems to be strongly related to kidney function and may therefore be important in investigating kidney function and related disorders. ..
  83. Schulze Wischeler J, Innocenti A, Vullo D, Agrawal A, Cohen S, Heine A, et al. Bidentate Zinc chelators for alpha-carbonic anhydrases that produce a trigonal bipyramidal coordination geometry. ChemMedChem. 2010;5:1609-15 pubmed publisher
    ..Further development of this ZBG should increase the binding affinity leading to a structurally distinct and promising class of CA inhibitors. ..
  84. Bähler M, Elfrink K, Hanley P, Thelen S, Xu Y. Cellular functions of class IX myosins in epithelia and immune cells. Biochem Soc Trans. 2011;39:1166-8 pubmed publisher
    ..Myo9a has been implicated in the regulation of epithelial cell morphology and differentiation, whereas Myo9b has been shown to play an important role in the regulation of macrophage shape and motility. ..
  85. Morgans C. Calcium channel heterogeneity among cone photoreceptors in the tree shrew retina. Eur J Neurosci. 1999;11:2989-93 pubmed
  86. Althaus M, Retzow A, Castell J, Gomez Lechon M, Amalou Z, Rose T, et al. In vitro identification of the cytochrome P450 isoform responsible for the metabolism of alpha-dihydroergocryptine. Xenobiotica. 2000;30:1033-45 pubmed
    ..3. The data suggest that DHEC metabolism in humans is primarily mediated by the CYP3A4 isoform. The results are in accordance with findings derived from other ergot alkaloids. ..
  87. Herlan M, Vogel F, Bornhovd C, Neupert W, Reichert A. Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem. 2003;278:27781-8 pubmed
    ..Therefore, processing of l-Mgm1 by Pcp1 and the presence of both isoforms of Mgm1 appear crucial for wild type mitochondrial morphology and maintenance of mitochondrial DNA. ..
  88. Kuhn S, Koch M, Nubel T, Ladwein M, Antolovic D, Klingbeil P, et al. A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression. Mol Cancer Res. 2007;5:553-67 pubmed
    ..However, claudin-7-associated EpCAM is recruited into TEM and forms a complex with CO-029 and CD44v6 that facilitates metastasis formation. ..
  89. Stock C, Ludwig F, Schwab A. Is the multifunctional Na(+)/H(+) exchanger isoform 1 a potential therapeutic target in cancer?. Curr Med Chem. 2012;19:647-60 pubmed
    ..Consequently, NHE1 including its regulators may represent potential targets in anticancer therapy. Different NHE1 inhibitors are compared and possible clinical exploitations of NHE1 inhibition are discussed. ..
  90. Tirado Gonzalez I, Freitag N, Barrientos G, Shaikly V, Nagaeva O, Strand M, et al. Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy. Mol Hum Reprod. 2013;19:43-53 pubmed publisher
    ..Circulating gal-1 levels could serve as a predictive factor for pregnancy success in early human gestation. ..
  91. Mittmann C, Schuler C, Chung C, Höppner G, Nose M, Kehrl J, et al. Evidence for a short form of RGS3 preferentially expressed in the human heart. Naunyn Schmiedebergs Arch Pharmacol. 2001;363:456-63 pubmed
    ..We conclude that an additional truncated form of RGS3 is expressed in the human heart. As described for the full-length protein, RGS3S negatively regulates the activity of Gi/o- and Gq-, but not Gs-subfamily members. ..
  92. Zhou X, Arntz C, Kamm S, Motejlek K, Sausbier U, Wang G, et al. A molecular switch for specific stimulation of the BKCa channel by cGMP and cAMP kinase. J Biol Chem. 2001;276:43239-45 pubmed
    ..Thus, phosphorylation/dephosphorylation by PKC determines whether the BK channel is stimulated by cGK or cAK. The molecular mechanisms may be relevant for smooth muscle relaxation by cAMP and cGMP. ..