Experts and Doctors on protein biosynthesis in Mexico


Locale: Mexico
Topic: protein biosynthesis

Top Publications

  1. Padilla Noriega L, Paniagua O, Guzmán León S. Rotavirus protein NSP3 shuts off host cell protein synthesis. Virology. 2002;298:1-7 pubmed
    ..Binding of eIF4G by NSP3 has been implicated in interfering with mRNA 5'-3' circularization, hence such circularization is essential for translation in mammalian cells. ..
  2. Montero H, Arias C, Lopez S. Rotavirus Nonstructural Protein NSP3 is not required for viral protein synthesis. J Virol. 2006;80:9031-8 pubmed
    ..These results indicate that NSP3 is neither required for the translation of viral mRNAs nor essential for virus replication in cell culture. ..
  3. Campos F, García Gómez B, Solorzano R, Salazar E, Estevez J, Leon P, et al. A cDNA for nuclear-encoded chloroplast translational initiation factor 2 from a higher plant is able to complement an infB Escherichia coli null mutant. J Biol Chem. 2001;276:28388-94 pubmed
    ..Phylogenetic analysis using the PvIF2cp conserved region suggests that the PvIF2cp gene originated via endosymbiotic gene transfer to the nucleus and that it may be a useful marker for phylogeny reconstruction. ..
  4. Rubio R, Mora S, Romero P, Arias C, Lopez S. Rotavirus prevents the expression of host responses by blocking the nucleocytoplasmic transport of polyadenylated mRNAs. J Virol. 2013;87:6336-45 pubmed publisher
    ..Altogether, these results suggest that nuclear retention of poly(A)-containing mRNAs is one of the main strategies of rotavirus to control cell translation and therefore the host antiviral and stress responses. ..
  5. Meneses A. Do serotonin(1-7) receptors modulate short and long-term memory?. Neurobiol Learn Mem. 2007;87:561-72 pubmed
    ..Concomitantly, these data indicate that '5-HT tone via 5-HT(1B) receptors' might function in a serial manner from STM to LTM, whereas working in parallel using 5-HT(1A), 5-HT(2A), 5-HT(2B/2C), 5-HT(4), or 5-HT(6) receptors. ..
  6. Gutiérrez Escolano A, Vázquez Ochoa M, Escobar Herrera J, Hernández Acosta J. La, PTB, and PAB proteins bind to the 3(') untranslated region of Norwalk virus genomic RNA. Biochem Biophys Res Commun. 2003;311:759-66 pubmed
    ..Since La, PTB, and PABP are important trans-acting factors required for viral translation and replication, these RNA-protein interactions may play a role in NV replication or translation. ..
  7. Romero V, Fellows E, Jenne D, Andrade F. Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity. Cell Death Differ. 2009;16:340-8 pubmed publisher
    ..The ability of gzmH to cleave host proteins involved in essential viral functions provides a novel mechanism by which granzymes can mediate direct antiviral activities. ..
  8. Cruz Morales P, Vijgenboom E, Iruegas Bocardo F, Girard G, Yañez Guerra L, Ramos Aboites H, et al. The genome sequence of Streptomyces lividans 66 reveals a novel tRNA-dependent peptide biosynthetic system within a metal-related genomic island. Genome Biol Evol. 2013;5:1165-75 pubmed publisher
  9. Contreras Treviño H, Reyna Rosas E, León Rodríguez R, Ruiz Ordaz B, Dinkova T, Cevallos A, et al. Species A rotavirus NSP3 acquires its translation inhibitory function prior to stable dimer formation. PLoS ONE. 2017;12:e0181871 pubmed publisher
    ..Our results demonstrate that rotavirus NSP3 acquires its function prior to stable dimer formation and remain as a proteasome target throughout dimerization. ..

More Information


  1. Ontiveros C, Valadez J, Hernandez J, Guarneros G. Inhibition of Escherichia coli protein synthesis by abortive translation of phage lambda minigenes. J Mol Biol. 1997;269:167-75 pubmed
    ..Starvation of the tRNA(s) sequestered in pepidyl-tRNA(s) eventually causes inhibition of protein synthesis. ..
  2. Mayorga J, Camacho Villasana Y, Shingú Vázquez M, García Villegas R, Zamudio Ochoa A, García Guerrero A, et al. A Novel Function of Pet54 in Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria. J Biol Chem. 2016;291:9343-55 pubmed publisher
    ..Pet54 may play a role in Mss51 hemylation/conformational change necessary for translational activity. Moreover, Pet54 physically interacts with the COX1 mRNA, and this binding was independent of the presence of Mss51. ..
  3. Hernández B, Sandoval Jaime C, Sosnovtsev S, Green K, Gutiérrez Escolano A. Nucleolin promotes in vitro translation of feline calicivirus genomic RNA. Virology. 2016;489:51-62 pubmed publisher
    ..These results suggest that NCL is part of the FCV RNA translational complex, and that the N-terminal part of the protein is required for efficient FCV replication. ..
  4. Medema M, Kottmann R, Yilmaz P, Cummings M, Biggins J, Blin K, et al. Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015;11:625-31 pubmed publisher
  5. Láscarez Lagunas L, Silva García C, Dinkova T, Navarro R. LIN-35/Rb causes starvation-induced germ cell apoptosis via CED-9/Bcl2 downregulation in Caenorhabditis elegans. Mol Cell Biol. 2014;34:2499-516 pubmed publisher
    ..We propose that CED-9/Bcl-2 downregulation via LIN-35/Rb triggers germ cell apoptosis in C. elegans in response to starvation. ..
  6. Tavares Carreón F, Camacho Villasana Y, Zamudio Ochoa A, Shingu Vazquez M, Torres Larios A, Perez Martinez X. The pentatricopeptide repeats present in Pet309 are necessary for translation but not for stability of the mitochondrial COX1 mRNA in yeast. J Biol Chem. 2008;283:1472-9 pubmed
    ..Our results show that the RNA metabolism function of Pet309 is found in at least two separate domains of the protein. ..
  7. Venkova Canova T, Soberón N, Ramírez Romero M, Cevallos M. Two discrete elements are required for the replication of a repABC plasmid: an antisense RNA and a stem-loop structure. Mol Microbiol. 2004;54:1431-44 pubmed
    ..Surprisingly, both of these seemingly negative regulators are required for efficient plasmid replication...
  8. Valadez J, Hernandez Sanchez J, Magos M, Ontiveros C, Guarneros G. Increased bar minigene mRNA stability during cell growth inhibition. Mol Microbiol. 2001;39:361-9 pubmed
    ..Higher mRNA stability correlated with the more toxic minigenes. We argue that this effect may be caused by ribosome protection of the mRNA in paused complexes as a result of deficiency of specific tRNA. ..
  9. Niquet J, Pérez Martínez L, Guerra M, Grouselle D, Joseph Bravo P, Charli J. Extracellular matrix proteins increase the expression of pro-TRH and pro-protein convertase PC1 in fetal hypothalamic neurons in vitro. Brain Res Dev Brain Res. 2000;120:49-56 pubmed
    ..In conclusion, we have shown that some ECM proteins increased pro-TRH level in vitro; this may contribute to the enhancement of pro-TRH levels observed early in vivo in the hypothalamus. ..
  10. De Nova Ocampo M, Villegas Sepúlveda N, Del Angel R. Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA. Virology. 2002;295:337-47 pubmed