Genomes and Genes
Experts and Doctors on protein binding in United Kingdom
Locale: United Kingdom
Topic: protein binding
Publications412 found, 100 shown here
- Cockman M, Lancaster D, Stolze I, Hewitson K, McDonough M, Coleman M, et al. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A. 2006;103:14767-72 pubmed
- Wayne G, Deng S, Amour A, Borman S, Matico R, Carter H, et al. TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4. J Biol Chem. 2007;282:20991-8 pubmed..The results of this study therefore indicate that the cartilage environment can modulate the function of enzyme-inhibitor systems and could have relevance for therapeutic approaches to aggrecanase modulation. ..
- Sanderson L, Khan A, Thomas S. Distribution of suramin, an antitrypanosomal drug, across the blood-brain and blood-cerebrospinal fluid interfaces in wild-type and P-glycoprotein transporter-deficient mice. Antimicrob Agents Chemother. 2007;51:3136-46 pubmed..Overall, the results confirm that [(3)H]suramin would be unlikely to treat the second or CNS stage of sleeping sickness. ..
- Barclay A. Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function. Curr Opin Immunol. 2009;21:47-52 pubmed publisher..The interaction may be modified by endocytosis of the receptors, cleavage by proteolysis and through interactions of surfactant proteins. ..
- Manzano D, Marquardt S, Jones A, Bäurle I, Liu F, Dean C. Altered interactions within FY/AtCPSF complexes required for Arabidopsis FCA-mediated chromatin silencing. Proc Natl Acad Sci U S A. 2009;106:8772-7 pubmed publisher..These altered interactions would appear to be a necessary step in this RNA-mediated chromatin silencing. ..
- Madigan J, Freeman D, Menzies F, Forrow S, Nelson S, Young A, et al. Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients. J Immunol. 2010;184:3202-12 pubmed publisher..These data support the view that trophoblast D6 scavenges maternal chemokines at the fetomaternal interface and that, in some circumstances, this can help to ensure fetal survival. ..
- Repellin C, Tsimbouri P, Philbey A, Wilson J. Lymphoid hyperplasia and lymphoma in transgenic mice expressing the small non-coding RNA, EBER1 of Epstein-Barr virus. PLoS ONE. 2010;5:e9092 pubmed publisher..This study is the first to describe the in vivo expression of a polymerase III, non-coding viral gene and demonstrate its oncogenic potential. The data suggest that EBER1 plays an oncogenic role in EBV associated malignant disease. ..
- Long J, Edwards J, Watson C, Tovey S, Mair K, Schiff R, et al. Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. Mol Cell Biol. 2010;30:3827-41 pubmed publisher..This is correlated with improved prognosis in patients who have a low HER1-3/SK1 expression ratio in their ER(+) breast cancer tumors compared to patients that have a high HER1-3/SK1 expression ratio. ..
- ..In this essay we discuss the mechanisms by which spatial regulation of BMP activity is achieved and its functional consequences. ..
- Divakaruni A, Humphrey D, Brand M. Fatty acids change the conformation of uncoupling protein 1 (UCP1). J Biol Chem. 2012;287:36845-53 pubmed publisher..Our results provide a framework for how fatty acids and nucleotides compete to regulate the activity of UCP1. ..
- Zanetti Domingues L, Martin Fernandez M, Needham S, Rolfe D, Clarke D. A systematic investigation of differential effects of cell culture substrates on the extent of artifacts in single-molecule tracking. PLoS ONE. 2012;7:e45655 pubmed publisher..The findings reported herein could be beneficial to a large number of experimental situations where single-molecule or single-particle precision is required. ..
- Yates L, Lumb C, Brahme N, Zalyte R, Bird L, De Colibus L, et al. Structural and functional characterization of the kindlin-1 pleckstrin homology domain. J Biol Chem. 2012;287:43246-61 pubmed publisher..We suggest the physiological ligand of the kindlin-1 PH domain is most likely not an inositol phosphate but another phosphorylated species. ..
- Perander M, Keyse S, Seternes O. New insights into the activation, interaction partners and possible functions of MK5/PRAK. Front Biosci (Landmark Ed). 2016;21:374-84 pubmed..Finally, we review recent literature that suggests novel biological functions for MK5 in a range of physiological and pathophysiological conditions including neuronal function and cancer. ..
- Wohl A, Troilo H, Collins R, Baldock C, Sengle G. Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1. J Biol Chem. 2016;291:12732-46 pubmed publisher..Together, these data show that upon prodomain binding to fibrillin-1, the BMP-7 complex undergoes a conformational change, which denies access of BMP receptors to the growth factor. ..
- Arnvig K, Pennell S, Gopal B, Colston M. A high-affinity interaction between NusA and the rrn nut site in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2004;101:8325-30 pubmed..Finally, we present evidence that this NusA-RNA interaction affects transcriptional events further downstream. ..
- Griffiths J, Murase K, Rieu I, Zentella R, Zhang Z, Powers S, et al. Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis. Plant Cell. 2006;18:3399-414 pubmed..Furthermore, yeast three-hybrid assays showed that the GA-GID1 complex promotes the interaction between RGA and the F-box protein SLY1, a component of the SCF(SLY1) E3 ubiquitin ligase that targets the DELLA protein for degradation. ..
- Savic M, Ilic Tomic T, Macmaster R, Vasiljevic B, Conn G. Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm. J Bacteriol. 2008;190:5855-61 pubmed publisher..These results represent the first functional characterization of any FmrO methyltransferase and may provide a basis for a further structure-function analysis of these aminoglycoside resistance determinants...
- Graham M, Edwards M, Holden Dye L, Morgan A, Burgoyne R, Barclay J. UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans. Mol Biol Cell. 2009;20:43-55 pubmed publisher..We conclude that ethanol acts, at least partially, at the level of vesicle fusion and that its acute effects are ameliorated by point mutations in UNC-18. ..
- Stewart A, Gómez Posada J, McGeorge J, Rouhani M, Villarroel A, Murrell Lagnado R, et al. The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement. J Biol Chem. 2012;287:11870-7 pubmed publisher..Hence, there are no constraints on either the subunit stoichiometry or the subunit arrangement. ..
- Douse C, Green J, Salgado P, Simpson P, Thomas J, Langsley G, et al. Regulation of the Plasmodium motor complex: phosphorylation of myosin A tail-interacting protein (MTIP) loosens its grip on MyoA. J Biol Chem. 2012;287:36968-77 pubmed publisher..Taken together these data support the notion that the conserved interactions between MTIP and MyoA may be specifically modulated by this post-translational modification. ..
- Watkins H, Chakravarthy M, Abhayawardana R, Gingell J, Garelja M, Pardamwar M, et al. Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties. J Biol Chem. 2016;291:11657-75 pubmed publisher..These subtype-specific differences have implications for the design of therapeutics aimed at specific AM receptors and for understanding the mechanisms by which accessory proteins affect G protein-coupled receptor function. ..
- Cory G, MacCarthy Morrogh L, Banin S, Gout I, Brickell P, Levinsky R, et al. Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. J Immunol. 1996;157:3791-5 pubmed..In this work, we show binding of WASP to the Src homology 3 domains of Btk, Itk, Tec, Grb2, and phospholipase C-gamma, which suggests a function for WASP in lymphoid cell signaling. ..
- Mak H, Hoare S, Henttu P, Parker M. Molecular determinants of the estrogen receptor-coactivator interface. Mol Cell Biol. 1999;19:3895-903 pubmed
- Taylor R, Moore D, Whitehouse J, Johnson P, Caldecott K. A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair. Mol Cell Biol. 2000;20:735-40 pubmed..This process correlates with the appearance of XRCC1 nuclear foci that colocalize with Rad51 and may thus function in concert with homologous recombination. ..
- Jones M, McColl I, Grant D, Parker K, Parker T. Protein adsorption and platelet attachment and activation, on TiN, TiC, and DLC coatings on titanium for cardiovascular applications. J Biomed Mater Res. 2000;52:413-21 pubmed..The good hemocompatibility of the DLC coating is attributed to its hydrophobicity and smooth surface, resulting in a higher ratio of albumin to fibrinogen than any of the other surfaces...
- Burden J, Sun X, García A, Soutar A. Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17. J Biol Chem. 2004;279:16237-45 pubmed..These results suggest that SNX17 plays a role in the cellular trafficking of the LDL receptor through interaction with the NPVY motif in its cytoplasmic domain and interaction of the PX domain with subcellular membrane compartments. ..
- Fedoroff O, Townson S, Golovanov A, Baron M, Avis J. The structure and dynamics of tandem WW domains in a negative regulator of notch signaling, Suppressor of deltex. J Biol Chem. 2004;279:34991-5000 pubmed..Our data illustrate that arrays of WW domains can exhibit a variety of higher order structures and ligand interaction mechanisms. ..
- Yap M, Nisole S, Stoye J. A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction. Curr Biol. 2005;15:73-8 pubmed..A single amino acid substitution (R332P) in the human Trim5alpha can confer the ability to restrict HIV-1, suggesting that small changes during evolution may have profound effects on our susceptibility to cross-species infection. ..
- Harvat E, Stevens J, Redfield C, Ferguson S. Functional characterization of the C-terminal domain of the cytochrome c maturation protein CcmE. J Biol Chem. 2005;280:36747-53 pubmed
- Seyfried J, Wang X, Kharebava G, Tournier C. A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway. Mol Cell Biol. 2005;25:9820-8 pubmed..Altogether these results establish that the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 signaling pathway. ..
- Wu L, Bachrati C, Ou J, Xu C, Yin J, Chang M, et al. BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Proc Natl Acad Sci U S A. 2006;103:4068-73 pubmed..Implications of the conserved ability of type IA topoisomerases to catalyze dissolution and how the evolution of factors such as BLAP75/RMI1 might confer specificity on the execution of this process are discussed. ..
- Harrison N, Lummis S. Locating the carboxylate group of GABA in the homomeric rho GABA(A) receptor ligand-binding pocket. J Biol Chem. 2006;281:24455-61 pubmed
- Ooi L, Belyaev N, Miyake K, Wood I, Buckley N. BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. J Biol Chem. 2006;281:38974-80 pubmed..Our data suggest that BRG1 facilitates REST repression by increasing the interaction between REST and chromatin. Such a mechanism may be applicable to other transcriptional repressors that utilize BRG1. ..
- Lin Y, Gregory V, Collins P, Kloess J, Wharton S, Cattle N, et al. Neuraminidase receptor binding variants of human influenza A(H3N2) viruses resulting from substitution of aspartic acid 151 in the catalytic site: a role in virus attachment?. J Virol. 2010;84:6769-81 pubmed publisher..It is apparent, however, that an important role of aspartic acid 151 in the activity of NA may be to restrict the specificity of the NA interaction and its receptor-destroying activity to complement that of HA receptor binding. ..
- Kerry P, Ayllon J, Taylor M, Hass C, Lewis A, Garcia Sastre A, et al. A transient homotypic interaction model for the influenza A virus NS1 protein effector domain. PLoS ONE. 2011;6:e17946 pubmed publisher..Such a concept may be applicable to other small multifunctional proteins. ..
- Foster Cuevas M, Westerholt T, Ahmed M, Brown M, Barclay A, Voigt S. Cytomegalovirus e127 protein interacts with the inhibitory CD200 receptor. J Virol. 2011;85:6055-9 pubmed publisher..It binds the host CD200R with the same affinity as that of the host protein, and thus this protein acts as a close mimic of the host protein and has the potential to downregulate immune responses to the virus. ..
- Driscoll H, Muraro N, He M, Baines R. Pumilio-2 regulates translation of Nav1.6 to mediate homeostasis of membrane excitability. J Neurosci. 2013;33:9644-54 pubmed publisher..Together, our results show that Pum2 forms part of a homeostatic mechanism that matches membrane excitability to synaptic depolarization in mammalian neurons. ..
- Herre J, Grönlund H, Brooks H, Hopkins L, Waggoner L, Murton B, et al. Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands. J Immunol. 2013;191:1529-35 pubmed publisher..We propose that Fel d 1 and Can f 6 belong to a group of allergen immunomodulatory proteins that enhance innate immune signaling and promote airway hypersensitivity reactions in diseases such as asthma. ..
- Yang S, Galanis A, Sharrocks A. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol Cell Biol. 1999;19:4028-38 pubmed
- Bingham R, Ekunwe S, Falk S, Snyder L, Kleanthous C. The major head protein of bacteriophage T4 binds specifically to elongation factor Tu. J Biol Chem. 2000;275:23219-26 pubmed
- Zatyka M, Bingle L, Jones A, Thomas C. Cooperativity between KorB and TrbA repressors of broad-host-range plasmid RK2. J Bacteriol. 2001;183:1022-31 pubmed
- Wientjes F, Reeves E, Soskic V, Furthmayr H, Segal A. The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain. Biochem Biophys Res Commun. 2001;289:382-8 pubmed..Furthermore, we show that its N-terminal part binds to the PX domain of p47phox and p40phox. ..
- Delehedde M, Lyon M, Vidyasagar R, McDonnell T, Fernig D. Hepatocyte growth factor/scatter factor binds to small heparin-derived oligosaccharides and stimulates the proliferation of human HaCaT keratinocytes. J Biol Chem. 2002;277:12456-62 pubmed
- Mould A, Askari J, Barton S, Kline A, McEwan P, Craig S, et al. Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain. J Biol Chem. 2002;277:19800-5 pubmed..The mechanism of beta subunit A-domain activation appears to be distinct from that of the A-domains found in some integrin alpha subunits. ..
- Burchmore R, Wallace L, Candlish D, Al Salabi M, Beal P, Barrett M, et al. Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. J Biol Chem. 2003;278:23502-7 pubmed..Expression of TbNBT1 in Xenopus oocytes further confirmed that this gene encodes the first high affinity nucleobase transporter from protozoa or animals to be identified at the molecular level. ..
- Allen S, Lu H, Thornton D, Tokatlidis K. Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. J Biol Chem. 2003;278:38505-13 pubmed..Taken together these data reveal this specific intramolecular disulfide bonding as the crucial mechanism for Tim10 folding and show that the inner cysteine pair has a more prominent role in this process. ..
- Toogood H, van Thiel A, Basran J, Sutcliffe M, Scrutton N, Leys D. Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex. J Biol Chem. 2004;279:32904-12 pubmed
- Ogundare M, Theofilopoulos S, Lockhart A, Hall L, Arenas E, Sjövall J, et al. Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain?. J Biol Chem. 2010;285:4666-79 pubmed publisher..Donkin, J., and Wellington C. (2009) Biofactors 35, 239-248); thus, cholesterol metabolites may play an important role in the etiology of Alzheimer disease. ..
- Thompson S, Jesudason E, Turnbull J, Fernig D. Heparan sulfate in lung morphogenesis: The elephant in the room. Birth Defects Res C Embryo Today. 2010;90:32-44 pubmed publisher..Finally, we will discuss the future possibility of HS-based therapeutics for ameliorating insufficient lung growth associated with lung diseases such as CDH. ..
- Belhouchet M, Mohd Jaafar F, Firth A, Grimes J, Mertens P, Attoui H. Detection of a fourth orbivirus non-structural protein. PLoS ONE. 2011;6:e25697 pubmed publisher..NS4 of both GIV and BTV protect DNA from degradation by DNAse. NS4 was found to associate with lipid droplets in cells infected with BTV or GIV or transfected with a plasmid expressing NS4. ..
- Theodorou V, Stark R, Menon S, Carroll J. GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility. Genome Res. 2013;23:12-22 pubmed publisher..Together, these experiments suggest that GATA3 directly impacts ESR1 enhancer accessibility, and may potentially explain the contribution of mutant-GATA3 in the heterogeneity of ESR1+ breast cancer. ..
- Erat M, Sladek B, Campbell I, Vakonakis I. Structural analysis of collagen type I interactions with human fibronectin reveals a cooperative binding mode. J Biol Chem. 2013;288:17441-50 pubmed publisher..Collagen association stabilizes a distinct monomeric GBD conformation in solution, giving further evidence to the view that FN fragments form well defined functional and structural units. ..
- Muniz J, Guo K, Kershaw N, Ayinampudi V, von Delft F, Babon J, et al. Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases. J Mol Biol. 2013;425:3166-77 pubmed publisher..This work highlights the adaptability of repeat domain proteins as scaffolds in substrate recognition and lays the foundation for future structure-function studies of this important E3 family. ..
- Gross B, Lee J, Clements J, Turner M, Tybulewicz V, Findell P, et al. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. J Biol Chem. 1999;274:5963-71 pubmed..This work identifies SLP-76 as an important adapter molecule that is regulated by Syk and lies upstream of SLAP-130 and PLC-gamma2 in CRP-stimulated platelets. ..
- Cannon W, Gallegos M, Buck M. DNA melting within a binary sigma(54)-promoter DNA complex. J Biol Chem. 2001;276:386-94 pubmed
- Allen J, Barker P, Ferguson S. A cytochrome b562 variant with a c-type cytochrome CXXCH heme-binding motif as a probe of the Escherichia coli cytochrome c maturation system. J Biol Chem. 2003;278:52075-83 pubmed..This contrasts with previous reports indicating that DsbA is essential for cytochrome c biogenesis in E. coli. ..
- Sayan B, Yang A, Conforti F, Tucci P, Piro M, Browne G, et al. Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2. Proc Natl Acad Sci U S A. 2010;107:12877-82 pubmed publisher..These results suggest that PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability, and, hence, it may offer a therapeutic approach to enhance the chemosensitivity of tumor cells. ..
- Zhang F, Moon A, Childs K, Goodbourn S, Dixon L. The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection. J Virol. 2010;84:10681-9 pubmed publisher..We therefore hypothesize that ASFV has other mechanisms to prevent the eIF2? phosphorylation and the subsequent protein synthesis inhibition...
- Cox G, Thompson G, Jenkins H, Peske F, Savelsbergh A, Rodnina M, et al. Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proc Natl Acad Sci U S A. 2012;109:2102-7 pubmed publisher..Ribosome clearance by these proteins represents a highly unusual antibiotic resistance mechanism, which appears to be fine-tuned by the relative abundance of FusB-type protein, ribosomes, and EF-G. ..
- Otero G, Fellows J, Li Y, de Bizemont T, Dirac A, Gustafsson C, et al. Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell. 1999;3:109-18 pubmed..Our data indicate that the transition from transcriptional initiation to elongation involves an exchange of the multiprotein mediator complex for elongator in a reaction coupled to CTD hyperphosphorylation. ..
- Day J, Olin A, Murdoch A, Canfield A, Sasaki T, Timpl R, et al. Alternative splicing in the aggrecan G3 domain influences binding interactions with tenascin-C and other extracellular matrix proteins. J Biol Chem. 2004;279:12511-8 pubmed..Our findings suggest that alternative splicing in the aggrecan G3 domain may be a mechanism for modulating interactions and extracellular matrix assembly. ..
- Penfold C, Healy B, Housden N, Boetzel R, Vankemmelbeke M, Moore G, et al. Flexibility in the receptor-binding domain of the enzymatic colicin E9 is required for toxicity against Escherichia coli cells. J Bacteriol. 2004;186:4520-7 pubmed..The data are consistent with a requirement for the flexibility of the coiled-coil R domain after binding to BtuB. ..
- Dornan D, Eckert M, Wallace M, Shimizu H, Ramsay E, Hupp T, et al. Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53. Mol Cell Biol. 2004;24:10083-98 pubmed..These data expand the core p300-p53 protein LXXLL and PXXP interface by including an IRF-1-p300 interface as an allosteric modifier of DNA-dependent acetylation of p53 at the p21 promoter. ..
- Nie M, Corbett L, Knox A, Pang L. Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. J Biol Chem. 2005;280:2550-61 pubmed..The interaction may have wide applications and may provide a potential target for pharmacological and molecular intervention. ..
- Moraes L, Paul Clark M, Rickman A, Flower R, Goulding N, Perretti M. Ligand-specific glucocorticoid receptor activation in human platelets. Blood. 2005;106:4167-75 pubmed..Taken together, our data suggest that platelet GR forms a heterodimeric complex with the mineralocorticoid receptor that is susceptible to differential activation by specific receptor ligands. ..
- Palma A, Feizi T, Zhang Y, Stoll M, Lawson A, Diaz Rodriguez E, et al. Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides. J Biol Chem. 2006;281:5771-9 pubmed
- Bunney T, Harris R, Gandarillas N, Josephs M, Roe S, Sorli S, et al. Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Mol Cell. 2006;21:495-507 pubmed..Studies of PLCepsilon regulation suggest that, in a cellular context, the RA2 domain, in a mode specific to PLCepsilon, has a role in membrane targeting with further regulatory impact on PLC activity. ..
- Lewin A, Crow A, Oubrie A, Le Brun N. Molecular basis for specificity of the extracytoplasmic thioredoxin ResA. J Biol Chem. 2006;281:35467-77 pubmed..Such a substratemediated activation mechanism is likely to have wide relevance for extracytoplasmic thioredoxins. ..
- Humphries J, Humphries M. CD14 is a ligand for the integrin alpha4beta1. FEBS Lett. 2007;581:757-63 pubmed..In summary, CD14 is a novel ligand for alpha4beta1, exhibiting similar activation-state dependent binding characteristics as other alpha4beta1 ligands. The biological relevance of this interaction will be the subject of further studies. ..
- Jones R, Ruas M, Gregory F, Moulin S, Delia D, Manoukian S, et al. A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6. Cancer Res. 2007;67:9134-41 pubmed..These observations suggest that CDK4 and CDK6 are not functionally redundant and underscore the importance of CDK4 in the development of melanoma. ..
- Faisal A, Saurin A, Gregory B, Foxwell B, Parker P. The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors. J Biol Chem. 2008;283:18591-600 pubmed publisher..This study therefore identifies the scaffold protein MyD88 as the link coupling TLRs to PKCepsilon recruitment, phosphorylation, and downstream signaling. ..
- Baur S, Marles Wright J, Buckenmaier S, Lewis R, Vollmer W. Synthesis of CDP-activated ribitol for teichoic acid precursors in Streptococcus pneumoniae. J Bacteriol. 2009;191:1200-10 pubmed publisher..CDP-activated ribitol is a precursor for the synthesis of pneumococcal teichoic acids and some of the capsular polysaccharides. Thus, all eight genes in the lic region have a role in teichoic acid synthesis...
- Kunzelmann S, Webb M. A biosensor for fluorescent determination of ADP with high time resolution. J Biol Chem. 2009;284:33130-8 pubmed publisher..The broad applicability of N-[2-(1-maleimidyl)ethyl]-7-diethylaminocoumarin-3-carboxamide (MDCC)-ParM as a sensitive probe for ADP is demonstrated in real-time kinetic assays on two different ATPases and a protein kinase. ..
- Harker N, Garefalaki A, Menzel U, Ktistaki E, Naito T, Georgopoulos K, et al. Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development. J Immunol. 2011;186:6368-77 pubmed publisher..Differential binding of Ikaros, NuRD, and heterochromatin protein 1? on the locus during these processes may participate in the complex regulation of CD8. ..
- Baird L, Lleres D, Swift S, Dinkova Kostova A. Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex. Proc Natl Acad Sci U S A. 2013;110:15259-64 pubmed publisher..quot; This previously unanticipated dynamism allows rapid transcriptional responses to environmental changes and can accommodate multiple modes of regulation. ..
- Picaud S, Wells C, Felletar I, Brotherton D, Martin S, Savitsky P, et al. RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc Natl Acad Sci U S A. 2013;110:19754-9 pubmed publisher..Our data demonstrate the feasibility of specific targeting within the BET family resulting in different transcriptional outcomes and highlight the importance of BD1 in transcriptional regulation. ..
- Randle S, Laman H. F-box protein interactions with the hallmark pathways in cancer. Semin Cancer Biol. 2016;36:3-17 pubmed publisher..We suggest six highly interconnected FBPs affecting multiple cancer hallmarks, which may prove sensible candidates for therapeutic intervention. ..
- Wu Z, Zhu D, Lin X, Miao J, Gu L, Deng X, et al. RNA Binding Proteins RZ-1B and RZ-1C Play Critical Roles in Regulating Pre-mRNA Splicing and Gene Expression during Development in Arabidopsis. Plant Cell. 2016;28:55-73 pubmed publisher..Our findings highlight the critical role of RZ-1B/1C in regulating RNA splicing, gene expression, and many key aspects of plant development via interaction with proteins including SR proteins. ..
- Spooner P, Rutherford N, Watts A, Henderson P. NMR observation of substrate in the binding site of an active sugar-H+ symport protein in native membranes. Proc Natl Acad Sci U S A. 1994;91:3877-81 pubmed
- Lyon M, Deakin J, Rahmoune H, Fernig D, Nakamura T, Gallagher J. Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate. J Biol Chem. 1998;273:271-8 pubmed..This is the first described example of a high affinity interaction between a growth factor and DS, and is likely to have significant implications for the biological activity of this paracrine-acting factor. ..
- Stacey M, Lin H, Hilyard K, Gordon S, McKnight A. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. J Biol Chem. 2001;276:18863-70 pubmed..These interactions suggest a potential role for EMR3 in myeloid-myeloid interactions during immune and inflammatory responses. ..
- Lecourtois M, Alexandre C, Dubois L, Vincent J. Wingless capture by Frizzled and Frizzled2 in Drosophila embryos. Dev Biol. 2001;235:467-75 pubmed..Receptor downregulation in the posterior compartment may contribute to dampening the signal at the time when cuticular fates are specified. ..
- Mant A, Woolhead C, Moore M, Henry R, Robinson C. Insertion of PsaK into the thylakoid membrane in a "Horseshoe" conformation occurs in the absence of signal recognition particle, nucleoside triphosphates, or functional albino3. J Biol Chem. 2001;276:36200-6 pubmed..The data raise the possibility of a wholly spontaneous insertion pathway. ..
- Bruce L, Pan R, Cope D, Uchikawa M, Gunn R, Cherry R, et al. Altered structure and anion transport properties of band 3 (AE1, SLC4A1) in human red cells lacking glycophorin A. J Biol Chem. 2004;279:2414-20 pubmed..Our results suggest that band 3 in the red cell can take up two different structures: one with high anion transport activity when GPA is present and one with lower anion transport activity when GPA is absent. ..