Experts and Doctors on protein binding in Italy


Locale: Italy
Topic: protein binding

Top Publications

  1. Barbato R, Menabo R, Dainese P, Carafoli E, Schiaffino S, Di Lisa F. Binding of cytosolic proteins to myofibrils in ischemic rat hearts. Circ Res. 1996;78:821-8 pubmed
    ..These changes of the myofibrillar proteins could be considered as intracellular markers of the evolution of the ischemic damage. In addition, the binding of the 23-kD peptide might be involved in alterations of contractility. ..
  2. Magenta A, Cenciarelli C, De Santa F, Fuschi P, Martelli F, Caruso M, et al. MyoD stimulates RB promoter activity via the CREB/p300 nuclear transduction pathway. Mol Cell Biol. 2003;23:2893-906 pubmed
    ..The resulting multiprotein complex stimulates transcription from the RB promoter. These and other observations strongly suggest that MyoD functions by promoting the efficient recruitment of p300 by promoter-bound, phosphorylated CREB. ..
  3. Stefano L, Racchetti G, Bianco F, Passini N, Gupta R, Panina Bordignon P, et al. The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. J Neurochem. 2009;110:284-94 pubmed publisher
    ..It might in contrast be appropriate for the binding of TREM2 to Hsp60 exposed at the surface of cells closely interacting with microglia. The ensuing stimulation of phagocytosis could play protective effects on the brain. ..
  4. Basile C, Libutti P, Teutonico A, Lomonte C. [Uremic toxins: the case of protein-bound compounds]. G Ital Nefrol. 2010;27:498-507 pubmed
  5. Federico S, Paoletta S, Cheong S, Pastorin G, Cacciari B, Stragliotto S, et al. Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility. J Med Chem. 2011;54:877-89 pubmed publisher
  6. Ognibene M, Vanni C, Segalerba D, Mancini P, Merello E, Torrisi M, et al. The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin. J Biol Chem. 2011;286:29973-83 pubmed publisher
    ..These results suggest that Dbl is regulated by hamartin through association with ezrin. ..
  7. Gussoni M, Scorciapino M, Vezzoli A, Anedda R, Greco F, Ceccarelli M, et al. Structural characterization of recombinant human myoglobin isoforms by (1)H and (129)Xe NMR and molecular dynamics simulations. Biochim Biophys Acta. 2011;1814:1919-29 pubmed publisher
    ..MD simulations supported NMR results indicating interesting structural/dynamical differences in the average volume and occurrence of the main cavities lining Mb prosthetic group. ..
  8. Ciaccio C, Pesce A, Tundo G, Tilleman L, Bertolacci L, Dewilde S, et al. Functional and structural roles of the N-terminal extension in Methanosarcina acetivorans protoglobin. Biochim Biophys Acta. 2013;1834:1813-23 pubmed publisher
    ..This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. ..
  9. Pesce A, Tilleman L, Donné J, Aste E, Ascenzi P, Ciaccio C, et al. Structure and haem-distal site plasticity in Methanosarcina acetivorans protoglobin. PLoS ONE. 2013;8:e66144 pubmed publisher

More Information

Publications454 found, 100 shown here

  1. Agostinis C, Durigutto P, Sblattero D, Borghi M, Grossi C, Guida F, et al. A non-complement-fixing antibody to ?2 glycoprotein I as a novel therapy for antiphospholipid syndrome. Blood. 2014;123:3478-87 pubmed publisher
    ..The CH2-deleted antibody represents an innovative approach potentially useful to treat APS patients refractory to standard therapy...
  2. Dunning A, Michailidou K, Kuchenbaecker K, Thompson D, French J, Beesley J, et al. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet. 2016;48:374-86 pubmed publisher
  3. Miotti S, Gulino A, Ferri R, Parenza M, Chronowska A, Lecis D, et al. Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities. FASEB J. 2017;31:5356-5370 pubmed publisher
    ..Ferri, R., Parenza, M., Chronowska, A., Lecis, D., Sangaletti, S., Tagliabue, E., Tripodo, C., Colombo, M. P. Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities. ..
  4. Malpeli G, Stoppini M, Zapponi M, Folli C, Berni R. Interactions with retinol and retinoids of bovine cellular retinol-binding protein. Eur J Biochem. 1995;229:486-93 pubmed
    ..The primary structure of bovine CRBP has been determined and is highly similar to the structures of both human and rat CRBP (97% and 95% identical, respectively). ..
  5. Neddermann P, Graziani R, Ciliberto G, Paonessa G. Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130. J Biol Chem. 1996;271:30986-91 pubmed
    ..These results strongly suggest that an as yet unidentified receptor beta-chain is involved in IL-11 signaling. ..
  6. Amodeo P, Castiglione Morelli M, Strazzullo G, Fucile P, Gautel M, Motta A. Kinase recognition by calmodulin: modeling the interaction with the autoinhibitory region of human cardiac titin kinase. J Mol Biol. 2001;306:81-95 pubmed
  7. Doliana R, Bot S, Mungiguerra G, Canton A, Cilli S, Colombatti A. Isolation and characterization of EMILIN-2, a new component of the growing EMILINs family and a member of the EMI domain-containing superfamily. J Biol Chem. 2001;276:12003-11 pubmed
  8. Artigiani S, Conrotto P, Fazzari P, Gilestro G, Barberis D, Giordano S, et al. Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep. 2004;5:710-4 pubmed
    ..We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3. ..
  9. Zanotti F, Raho G, Gaballo A, Papa S. Inhibitory and anchoring domains in the ATPase inhibitor protein IF1 of bovine heart mitochondrial ATP synthase. J Bioenerg Biomembr. 2004;36:447-57 pubmed
    ..This binding keeps IF1 anchored to the complex, both under inhibitory conditions, at acidic pH, and noninhibitory conditions at alkaline pH. ..
  10. Rossi R, Maffei M, Bottinelli R, Canepari M. Temperature dependence of speed of actin filaments propelled by slow and fast skeletal myosin isoforms. J Appl Physiol (1985). 2005;99:2239-45 pubmed
    ..However, slow myosin isoforms did not show a higher temperature sensitivity than fast isoforms, contrary to what was observed in intact slow and fast muscles. ..
  11. Andreotti G, Méndez B, Amodeo P, Morelli M, Nakamuta H, Motta A. Structural determinants of salmon calcitonin bioactivity: the role of the Leu-based amphipathic alpha-helix. J Biol Chem. 2006;281:24193-203 pubmed
    ..Taken together, the structural and biological data identify well defined structural parameters of the helix for sCT bioactivity. ..
  12. Righetti S, Perego P, Carenini N, Zunino F. Cooperation between p53 and p73 in cisplatin-induced apoptosis in ovarian carcinoma cells. Cancer Lett. 2008;263:140-4 pubmed publisher
    ..Although p73 appears to be implicated mainly in response to high stress conditions, the available results support a cooperation between p53 and p73 in cisplatin-induced apoptosis in sensitive cells. ..
  13. Trentin L, Frasson M, Donella Deana A, Frezzato F, Pagano M, Tibaldi E, et al. Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia. Blood. 2008;112:4665-74 pubmed publisher
    ..These data identify the CL complex as a potential target for therapy in B-CLL. ..
  14. Sturla L, Fresia C, Guida L, Bruzzone S, Scarfi S, Usai C, et al. LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells. J Biol Chem. 2009;284:28045-57 pubmed publisher
    ..Identification of LANCL2 as a critical component of the ABA-sensing protein complex will enable the screening of synthetic ABA antagonists as prospective new anti-inflammatory and anti-diabetic agents...
  15. Nicoletti F, Comandini A, Bonamore A, Boechi L, Boubeta F, Feis A, et al. Sulfide binding properties of truncated hemoglobins. Biochemistry. 2010;49:2269-78 pubmed publisher
    ..The high affinity for hydrogen sulfide is thought to have a possible physiological significance as H(2)S is produced in bacteria at metabolic steps involved in cysteine biosynthesis and hence in thiol redox homeostasis...
  16. Marchetti L, Callegari A, Luin S, Signore G, Viegi A, Beltram F, et al. Ligand signature in the membrane dynamics of single TrkA receptor molecules. J Cell Sci. 2013;126:4445-56 pubmed publisher
    ..Thus, our data uncover a close correlation between the initial receptor membrane dynamics triggered upon binding and the specific biological outcomes induced by different ligands for the same receptor. ..
  17. Rondelli V, Brocca P, Motta S, Messa M, Colombo L, Salmona M, et al. Amyloid-β peptides in interaction with raft-mime model membranes: a neutron reflectivity insight. Sci Rep. 2016;6:20997 pubmed publisher
    ..Instead, it was seen to remove lipids from the bilayer, thus suggesting its role, once in the whole peptide, in membrane leakage, favouring peptide recruitment. ..
  18. Pischedda C, Cocco S, Melis A, Marini M, Kan Y, Cao A, et al. Isolation of a differentially regulated splicing isoform of human NF-E2. Proc Natl Acad Sci U S A. 1995;92:3511-5 pubmed
    ..fNF-E2 is more abundant in the fetal liver and less abundant in the adult bone marrow compared to the previously described form. Their distribution apparently follows the differential expression of fetal and adult hemoglobins. ..
  19. Grisendi S, Chambraud B, Gout I, Comoglio P, Crepaldi T. Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor. J Biol Chem. 2001;276:46632-8 pubmed
    ..Significantly, nonphosphorylated HGF receptor prevents FAP68 from stimulating p70S6K. These data suggest a role for FAP68 in coupling HGF receptor signaling to the p70S6K pathway. ..
  20. Tarricone C, Dhavan R, Peng J, Areces L, Tsai L, Musacchio A. Structure and regulation of the CDK5-p25(nck5a) complex. Mol Cell. 2001;8:657-69 pubmed
    ..Finally, we provide evidence that the CDK5-p25 complex employs a distinct mechanism from the phospho-CDK2-cyclin A complex to establish substrate specificity. ..
  21. Tosoni D, Puri C, Confalonieri S, Salcini A, De Camilli P, Tacchetti C, et al. TTP specifically regulates the internalization of the transferrin receptor. Cell. 2005;123:875-88 pubmed
    ..Thus, TTP might represent one of the long sought for molecules that allow cargo-specific control of clathrin endocytosis...
  22. Caserta E, Tomsic J, Spurio R, La Teana A, Pon C, Gualerzi C. Translation initiation factor IF2 interacts with the 30 S ribosomal subunit via two separate binding sites. J Mol Biol. 2006;362:787-99 pubmed
  23. Vitagliano L, Ruggiero A, Pedone C, Berisio R. A molecular dynamics study of pilus subunits: insights into pilus biogenesis. J Mol Biol. 2007;367:935-41 pubmed
    ..These data suggest that chaperone release and pilin-pilin association must be concerted processes and that chaperone plays an important role in preventing pilin transitions towards states that are not prone to polymerise. ..
  24. Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, et al. Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength. Biochemistry. 2008;47:6928-35 pubmed publisher
  25. Gourlay L, Santi I, Pezzicoli A, Grandi G, Soriani M, Bolognesi M. Group B streptococcus pullulanase crystal structures in the context of a novel strategy for vaccine development. J Bacteriol. 2009;191:3544-52 pubmed publisher
    ..1 and 2.4 A, respectively. ..
  26. Tasso B, Canu Boido C, Terranova E, Gotti C, Riganti L, Clementi F, et al. Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes. J Med Chem. 2009;52:4345-57 pubmed publisher
  27. Cannino G, Ferruggia E, Rinaldi A. Proteins participating to the post-transcriptional regulation of the mitochondrial cytochrome c oxidase subunit IV via elements located in the 3'UTR. Mitochondrion. 2009;9:471-80 pubmed publisher
    ..We hypothesize a new post-transcriptional mechanism regulating a messenger encoded by nuclear genome for a mitochondrial protein and that Hsp90 and Actin, could represent key players in COXIV translation. ..
  28. Shaik M, Cendron L, Percudani R, Zanotti G. The structure of Helicobacter pylori HP0310 reveals an atypical peptidoglycan deacetylase. PLoS ONE. 2011;6:e19207 pubmed publisher
    ..In striking contrast with the known peptidoglycan deacetylases, HpPgdA does not exhibit a solvent-accessible polysaccharide binding groove, suggesting that the enzyme binds a small molecule at the active site. ..
  29. Medici S, Peana M, Delogu L, Zoroddu M. Mn(II) and Zn(II) interactions with peptide fragments from Parkinson's disease genes. Dalton Trans. 2012;41:4378-88 pubmed publisher
    ..The failure of Ca(II) ions to bind to either peptide (1) or (2) appears to result, under our conditions, from the absence of chelating properties in the chosen fragments. ..
  30. Montefusco S, Esposito R, D Andrea L, Monti M, Dunne C, Dolan B, et al. Copper promotes TFF1-mediated Helicobacter pylori colonization. PLoS ONE. 2013;8:e79455 pubmed publisher
    ..pylori colonisation. Finally, SPR analysis shows that the C-terminus of TFF1, involved in the binding of copper, is also able to selectively bind H. pylori RF-LPS. ..
  31. Verstegen A, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, et al. Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses. J Neurosci. 2014;34:7266-80 pubmed publisher
    ..The phosphorylation state of SynI by Cdk5 at site 7 is regulated during chronic modification of neuronal activity and is an essential downstream effector for the Cdk5-mediated homeostatic scaling...
  32. Rigiracciolo D, Scarpelli A, Lappano R, Pisano A, Santolla M, Avino S, et al. GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells. Oncotarget. 2016;7:94-111 pubmed publisher
    ..Our data further extend the current knowledge on the molecular mechanisms through which GPER may contribute to the stimulatory action elicited by aldosterone in breast cancer. ..
  33. Tong H, Cavallotti C, Yao S, Lin D. Molecular insight into protein binding orientations and interaction modes on hydrophobic charge-induction resin. J Chromatogr A. 2017;1512:34-42 pubmed publisher
    ..At acidic pH, the electrostatic repulsion between the basic residues and the protonated pyridine ring group on MEP ligands is the main driving force for the detachment of the Fc fragment from the MEP net. ..
  34. Sousa V, Bellani S, Giannandrea M, Yousuf M, Valtorta F, Meldolesi J, et al. {alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamics. Mol Biol Cell. 2009;20:3725-39 pubmed publisher
    ..Actin cytoskeletal disruption induced by the A30P mutant might alter various cellular processes and thereby play a role in the pathogenesis of neurodegeneration. ..
  35. Cesca F, Baldelli P, Valtorta F, Benfenati F. The synapsins: key actors of synapse function and plasticity. Prog Neurobiol. 2010;91:313-48 pubmed publisher
  36. Dianzani U, Bragardo M, Buonfiglio D, Redoglia V, Funaro A, Portoles P, et al. Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120. Eur J Immunol. 1995;25:1306-11 pubmed
    ..Since both CD59 and gp120 bind complement, the observed association could be mediated by complement components. ..
  37. Iannolo G, Minenkova O, Gonfloni S, Castagnoli L, Cesareni G. Construction, exploitation and evolution of a new peptide library displayed at high density by fusion to the major coat protein of filamentous phage. Biol Chem. 1997;378:517-21 pubmed
    ..We propose that the assembly secretion process is favoured in phages displaying this family of peptides since they fit the groove between two adjacent PVIII subunits by making advantageous molecular contacts on the phage surface...
  38. Clerici M, Paciotti V, Baldo V, Romano M, Lucchini G, Longhese M. Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression. EMBO J. 2001;20:6485-98 pubmed
    ..In addition, Tel1 overproduction results in transient nuclear division arrest and concomitant Rad53 phosphorylation in the absence of exogenous DNA damage independently of Mec1 and Ddc1. ..
  39. di Paolo M, Scarpa M, Corazza A, Stevanato R, Rigo A. Binding of cations of group IA and IIA to bovine serum amine oxidase: effect on the activity. Biophys J. 2002;83:2231-9 pubmed
    ..An additional cation-binding area, where metal ions such as Cs(+) (K(d) congruent with 0.1 mM) and Na(+) (K(d) congruent with 54 mM) bind without affecting the enzyme activity, was found by NMR...
  40. Ferrari A, Maretto S, Girotto D, Volpin D, Bressan G. SREBP contributes to induction of collagen VI transcription by serum starvation. Biochem Biophys Res Commun. 2004;313:600-5 pubmed
    ..Furthermore, our data unveil a previously unexpected link between extracellular matrix production and LDL signaling. ..
  41. Pandini A, Bonati L. Conservation and specialization in PAS domain dynamics. Protein Eng Des Sel. 2005;18:127-37 pubmed
    ..These findings may give insight into unknown mechanisms of PAS domains and guide further experimental studies...
  42. Lamberti A, Longo O, Del Vecchio P, Zambrano N, Barone G, Russo T, et al. Probing the secondary structure of a recombinant neuronal adaptor protein and its phosphotyrosine binding domains. Biosci Biotechnol Biochem. 2005;69:2395-400 pubmed
    ..These data provide first evidences on the secondary structural levels of Fe65. ..
  43. Scaggiante B, Dapas B, Grassi G, Manzini G. Interaction of G-rich GT oligonucleotides with nuclear-associated eEF1A is correlated with their antiproliferative effect in haematopoietic human cancer cell lines. FEBS J. 2006;273:1350-61 pubmed
    ..The cytotoxicity of G-rich GT oligomers was shown to be tightly related to their binding affinity for eEF1A protein. ..
  44. Merluzzi S, D Orlando O, Leonardi A, Vitale G, Pucillo C. TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation. Mol Immunol. 2008;45:76-86 pubmed
    ..These data together uncovers a new signaling pathway regulating APE/Ref-1 nuclear translocation involving CD40-crosslinking, TRAF2 and p38. ..
  45. Di Maro A, Chambery A, Carafa V, Costantini S, Colonna G, Parente A. Structural characterization and comparative modeling of PD-Ls 1-3, type 1 ribosome-inactivating proteins from summer leaves of Phytolacca dioica L. Biochimie. 2009;91:352-63 pubmed publisher
    ..Despite an overall high structural similarity, the comparative modeling of PD-L1, PD-L2, PD-L3 and PD-L4 has shown potential influences of the glycidic chains on their adenine polynucleotide glycosylase activity on different substrates...
  46. Manzoni C, Colombo L, Bigini P, Diana V, Cagnotto A, Messa M, et al. The molecular assembly of amyloid a? controls its neurotoxicity and binding to cellular proteins. PLoS ONE. 2011;6:e24909 pubmed publisher
    ..Based on these data we suggest that numerous proteins act as A? receptors in N2a cells, triggering a multi factorial toxicity. ..
  47. Margarucci L, Monti M, Mencarelli A, Cassiano C, Fiorucci S, Riccio R, et al. Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C. Mol Biosyst. 2012;8:1412-7 pubmed publisher
  48. Sandri C, Caccavari F, Valdembri D, Camillo C, Veltel S, Santambrogio M, et al. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res. 2012;22:1479-501 pubmed publisher
  49. Berni R, Stoppini M, Zapponi M, Meloni M, Monaco H, Zanotti G. The bovine plasma retinol-binding protein. Amino acid sequence, interaction with transthyretin, crystallization and preliminary X-ray data. Eur J Biochem. 1990;192:507-13 pubmed
    ..3. Bovine RBP has been crystallized (space group P2(1)2(1)2(1), with a = 4.61 nm, b = 4.91 nm, c = 7.61 nm) and the crystals are suitable for high-resolution X-ray diffraction studies. ..
  50. Pinter C, Siccardi A, Longhi R, Clivio A. Direct interaction of complement factor H with the C1 domain of HIV type 1 glycoprotein 120. AIDS Res Hum Retroviruses. 1995;11:577-88 pubmed
    ..In this article we describe the biochemical characterization of this protein, which turned out to be complement factor H (CFH). We propose a functional role for this protein in the complex, early steps of CD4-dependent HIV infection. ..
  51. Vindigni A, Ochem A, Triolo G, Falaschi A. Identification of human DNA helicase V with the far upstream element-binding protein. Nucleic Acids Res. 2001;29:1061-7 pubmed
    ..The sequence of HDH V/FBP contains RGG motifs like HDH IV/nucleolin, HDH VIII/G3BP as well as other human RNA and DNA helicases identified by other laboratories. ..
  52. Migliorini D, Danovi D, Colombo E, Carbone R, Pelicci P, Marine J. Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation. J Biol Chem. 2002;277:7318-23 pubmed
    ..It appears, therefore, that a regulatory loop exists in which Hdm2 regulates the intracellular localization of Hdmx, and nuclear Hdmx regulates several functions of Hdm2 (ubiquitin ligase activity and p53 nuclear export). ..
  53. Bertucci C, Cimitan S. Inhibition of drug binding to human serum albumin by cholecystographic agents. Farmaco. 2003;58:901-8 pubmed
    ..Binding parameters were obtained by optical biosensor analysis: K(D) values were 3.6 x 10(-7) and 2.8 x 10(-8) M for IOP and IOPH, respectively. ..
  54. Dimasi N, Biassoni R. Structural and functional aspects of the Ly49 natural killer cell receptors. Immunol Cell Biol. 2005;83:1-8 pubmed
  55. Gardoni F, Picconi B, Ghiglieri V, Polli F, Bagetta V, Bernardi G, et al. A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. J Neurosci. 2006;26:2914-22 pubmed
    ..These data indicate abnormal NR2B redistribution between synaptic and extrasynaptic membranes as an important molecular disturbance of the glutamatergic synapse involved in L-DOPA-induced dyskinesia. ..
  56. Borello U, Berarducci B, Murphy P, Bajard L, Buffa V, Piccolo S, et al. The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development. 2006;133:3723-32 pubmed
    ..Taken together, these results demonstrate that Myf5 is a direct target of Wnt/beta-catenin, and that its full activation requires a cooperative interaction between the canonical Wnt and the Shh/Gli pathways in muscle progenitor cells. ..
  57. Oleggini R, Gastaldo N, Di Donato A. Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effects. Matrix Biol. 2007;26:494-505 pubmed
    ..Many of those included SMAD transcription factors. Two more restricted regions binding AP1 and SMAD were identified as mediators of LOX effects and of LOX and TGF-beta1 cross-inhibition. ..
  58. Martinato F, Cesaroni M, Amati B, Guccione E. Analysis of Myc-induced histone modifications on target chromatin. PLoS ONE. 2008;3:e3650 pubmed publisher
    ..Our data are also consistent with the additive and redundant role of multiple acetylation events in transcriptional activation. ..
  59. Verderio C, Cagnoli C, Bergami M, Francolini M, Schenk U, Colombo A, et al. TI-VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes. Biol Cell. 2012;104:213-28 pubmed publisher
  60. Mapelli M, Gonzalez C. On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN. Open Biol. 2012;2:120102 pubmed publisher
    ..However, recent structural studies revealed the Insc and NuMA are mutually exclusive interactors of LGN, implying that the molecular mechanism of spindle coupling to polarity is more sophisticated than has been believed to date. ..
  61. Ballabio C, Peñas E, Uberti F, Fiocchi A, Duranti M, Magni C, et al. Characterization of the sensitization profile to lupin in peanut-allergic children and assessment of cross-reactivity risk. Pediatr Allergy Immunol. 2013;24:270-5 pubmed publisher
    ..The role of ?-conglutin in the cross-reactivity between lupin and peanut proteins was also relevant and clear, despite the observed unspecificity of the immunoblotting responses. ..
  62. Ascenzi P, Coletta A, Cao Y, Trezza V, Leboffe L, Fanali G, et al. Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N. PLoS ONE. 2013;8:e69762 pubmed publisher
    ..These data suggest a direct role of isoniazid to impair fundamental functions of mycobacteria, e.g. scavenging of reactive nitrogen and oxygen species, and metabolism. ..
  63. Cassani C, Raspelli E, Santo N, Chiroli E, Lucchini G, Fraschini R. Saccharomyces cerevisiae Dma proteins participate in cytokinesis by controlling two different pathways. Cell Cycle. 2013;12:2794-808 pubmed publisher
    ..Altogether, these findings suggest that the Dma proteins act as negative regulators of cytokinesis. ..
  64. Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, et al. p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria. J Biol Chem. 2016;291:12575-85 pubmed publisher
    ..The thiolase-p46Shc connection shown here in vitro and in organello may be an important underlying mechanism explaining the metabolic phenotype of Shc-depleted mice in vivo. ..
  65. Egorov M, Capestrano M, Vorontsova O, Di Pentima A, Egorova A, Mariggio S, et al. Faciogenital dysplasia protein (FGD1) regulates export of cargo proteins from the golgi complex via Cdc42 activation. Mol Biol Cell. 2009;20:2413-27 pubmed publisher
    ..These effects depend on FGD1 regulation of Cdc42 activation and its association with the Golgi membranes, and they may contribute to FGDY pathogenesis. ..
  66. Kumar A, Hajjar E, Ruggerone P, Ceccarelli M. Molecular simulations reveal the mechanism and the determinants for ampicillin translocation through OmpF. J Phys Chem B. 2010;114:9608-16 pubmed publisher
    ..As a whole, our analysis opens the way to chemical modifications of antibiotics to allow improving uptake through porins contributing to combat bacterial resistance. ..
  67. De Luca L, Ferro S, Gitto R, Barreca M, Agnello S, Christ F, et al. Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor. Bioorg Med Chem. 2010;18:7515-21 pubmed publisher
    ..The results obtained demonstrate that the hydrophobic pocket could play a key role in improving inhibitory efficacy thus opening new suggestions to design active ligands. ..
  68. Galati A, Magdinier F, Colasanti V, Bauwens S, Pinte S, Ricordy R, et al. TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner. PLoS ONE. 2012;7:e34386 pubmed publisher
    ..These findings raise the intriguing possibility that telomere protection is mediated, at least in part, by the TRF2-dependent regulation of nucleosome organization. ..
  69. Mannini L, Cucco F, Quarantotti V, Amato C, Tinti M, Tana L, et al. SMC1B is present in mammalian somatic cells and interacts with mitotic cohesin proteins. Sci Rep. 2015;5:18472 pubmed publisher
    ..Genome-wide analyses show that cluster genes changing in expression are enriched for cohesin-SMC1B binding. ..
  70. Streubel G, Fitzpatrick D, Oliviero G, Scelfo A, Moran B, Das S, et al. Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. EMBO J. 2017;36:2216-2232 pubmed publisher
    ..Taken together, Fam60a is an essential core subunit of a variant Sin3a complex in ES cells that is required to promote rapid proliferation and prevent unscheduled differentiation. ..
  71. Zalfa F, Giorgi M, Primerano B, Moro A, Di Penta A, Reis S, et al. The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses. Cell. 2003;112:317-27 pubmed
    ..Thus, when FMRP is not present, loss of translational repression of specific mRNAs at synapses could result in synaptic dysfunction phenotype of Fragile X patients. ..
  72. Arena S, Pattarozzi A, Massa A, Esteve J, Iuliano R, Fusco A, et al. An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta. Mol Endocrinol. 2007;21:229-46 pubmed
    ..In particular the sequential activation of JAK2, SHP-2, and Src conveys the molecular signaling from SSTR1 to the activation of this phosphatase that is responsible for the final biological effects of SST. ..
  73. Zara V, Ferramosca A, Robitaille Foucher P, Palmieri F, Young J. Mitochondrial carrier protein biogenesis: role of the chaperones Hsc70 and Hsp90. Biochem J. 2009;419:369-75 pubmed publisher
    ..We propose that carrier presequences evolved to improve targeting competence by different mechanisms, depending on physical properties of the precursors in the cytosolic targeting environment. ..
  74. Pastorello E, Pravettoni V, Farioli L, Primavesi L, Scibilia J, Piantanida M, et al. Green bean (Phaseolus vulgaris): a new source of IgE-binding lipid transfer protein. J Agric Food Chem. 2010;58:4513-6 pubmed publisher
    ..A complete inhibition of the IgE binding to this protein, in both raw and purified extract, was obtained by purified peach Pru p 3, confirming previous IgE immunoblotting results. ..
  75. Stefanachi A, Favia A, Nicolotti O, Leonetti F, Pisani L, Catto M, et al. Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-?-hydroxylase/C17-20 lyase. J Med Chem. 2011;54:1613-25 pubmed publisher
  76. Csorba T, Burgyan J. Gel mobility shift assays for RNA binding viral RNAi suppressors. Methods Mol Biol. 2011;721:245-52 pubmed publisher
    ..Here, we provide a detailed protocol for the analysis of crucifer-infecting Tobacco mosaic tobamovirus (cr-TMV) silencing suppressor protein p122 RNA binding capacity. ..
  77. Bruschi F, Carulli G, Azzara A, Homan W, Minnucci S, Rizzuti Gullaci A, et al. Inhibitory effects of human neutrophil functions by the 45-kD glycoprotein derived from the parasitic nematode Trichinella spiralis. Int Arch Allergy Immunol. 2000;122:58-65 pubmed
    ..Furthermore, gp45 significantly reduced the upregulation of the CD11b induced by f-MLP. The results show that gp45 inhibits PMN in different functions, suggesting an anti-inflammatory action. ..
  78. Petrelli A, Gilestro G, Lanzardo S, Comoglio P, Migone N, Giordano S. The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. Nature. 2002;416:187-90 pubmed
    ..These data provide further evidence of a relationship between receptor-mediated signalling and endocytosis, and disclose a novel functional role for Cbl in HGF receptor signalling. ..
  79. Losasso C, Cretaio E, Fiorani P, D Annessa I, Chillemi G, Benedetti P. A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance. Nucleic Acids Res. 2008;36:5635-44 pubmed publisher
    ..We postulate that the maintenance of the hydrophobic pocket integrity, where Thr729 is positioned, is crucial for drug sensitivity and DNA binding. ..
  80. Pedrotti B, Colombo R, Islam K. Microtubule associated protein MAP1A is an actin-binding and crosslinking protein. Cell Motil Cytoskeleton. 1994;29:110-6 pubmed
    ..The widespread distribution of MAP1A and its interaction with microtubules, actin, and intermediate filaments suggests that it may constitute an important determinant of neuronal and non-neuronal cellular morphology. ..
  81. Mai A, Massa S, Ragno R, Esposito M, Sbardella G, Nocca G, et al. Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. J Med Chem. 2002;45:1778-84 pubmed
  82. Ragno R, Mai A, Massa S, Cerbara I, Valente S, Bottoni P, et al. 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. J Med Chem. 2004;47:1351-9 pubmed publisher
    ..Compound 4, tested as antiproliferative and cytodifferentiating agent on MEL cells, showed dose-dependent growth inhibition and hemoglobin accumulation effects...
  83. Giangrossi M, Zattoni S, Tramonti A, De Biase D, Falconi M. Antagonistic role of H-NS and GadX in the regulation of the glutamate decarboxylase-dependent acid resistance system in Escherichia coli. J Biol Chem. 2005;280:21498-505 pubmed
    ..Altogether, our results indicate that H-NS directly inhibits gadA and gadX transcription and, by controlling the intracellular level of the activator GadX, indirectly affects the expression of the whole gad system. ..
  84. Mariggio S, Iurisci C, Sebastia J, Patton Vogt J, Corda D. Molecular characterization of a glycerophosphoinositol transporter in mammalian cells. FEBS Lett. 2006;580:6789-96 pubmed
    ..These data identify Glut2 as a GroPIns transporter in mammals, and define a physiologically relevant cell-permeation mechanism. ..
  85. Scotto D Abusco A, Calamia V, Cicione C, Grigolo B, Politi L, Scandurra R. Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes. Arthritis Res Ther. 2007;9:R104 pubmed
    ..These findings demonstrate, for the first time, that glucosamine inhibits IL-1beta-stimulated MMP production in human chondrocytes by affecting MAPK phosphorylation. ..
  86. Capanni C, Del Coco R, Squarzoni S, Columbaro M, Mattioli E, Camozzi D, et al. Prelamin A is involved in early steps of muscle differentiation. Exp Cell Res. 2008;314:3628-37 pubmed publisher
    ..Our data provide evidence for a critical role of the lamin A precursor in the early steps of muscle cell differentiation. ..
  87. Bruno O, Brullo C, Bondavalli F, Schenone S, Spisani S, Falzarano M, et al. 1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors. Bioorg Med Chem. 2009;17:3379-87 pubmed publisher
    ..In vivo compounds 2e and 2f, although to a lesser extent, at 50mg/kg os decreased granulocyte infiltration in zymosan-induced peritonitis in mice. ..
  88. Barbiroli A, Beringhelli T, Bonomi F, Donghi D, Ferranti P, Galliano M, et al. Bovine beta-lactoglobulin acts as an acid-resistant drug carrier by exploiting its diverse binding regions. Biol Chem. 2010;391:21-32 pubmed publisher
  89. Patil P, Gemma S, Campiani G, Craig A. Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate. Malar J. 2011;10:348 pubmed publisher
    ..falciparum showed that this inhibitor, identified as potential mimic of the L43 loop of human ICAM-1, was effective at blocking cytoadherence. ..
  90. Nazzaro C, Greco B, Cerovic M, Baxter P, Rubino T, Trusel M, et al. SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance. Nat Neurosci. 2012;15:284-93 pubmed publisher
    ..In addition, SK channels emerge as molecular targets to fine tune the eCB pathway under pathological conditions. ..
  91. Rusolo F, Pucci B, Colonna G, Capone F, Guerriero E, Milone M, et al. Evaluation of selenite effects on selenoproteins and cytokinome in human hepatoma cell lines. Molecules. 2013;18:2549-62 pubmed publisher
    ..Finally, interactomic studies show that GPX1 and SELK, and the four pro-inflammatory cytokines are functionally correlated evidencing a putative anti-inflammatory role for the selenite. ..
  92. Croci R, Tarantino D, Milani M, Pezzullo M, Rohayem J, Bolognesi M, et al. PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. FEBS Lett. 2014;588:1720-5 pubmed publisher
    ..Such inhibitor-binding mode mimics two stacked nucleotide-bases of the RdRp/ssRNA complex. ..