Experts and Doctors on protease inhibitors in Australia

Summary

Locale: Australia
Topic: protease inhibitors

Top Publications

  1. Rogers A, Gunadi A, Gully N, Zilm P. An aminopeptidase nutritionally important to Fusobacterium nucleatum. Microbiology. 1998;144 ( Pt 7):1807-13 pubmed
    ..nucleatum in the subgingival environment of the mouth. ..
  2. Piva T, Francis K, Krause D, Chojnowski G, Ellem K. Effect of UV irradiation on cell surface protease activity and amino acid uptake. Mutat Res. 1998;422:55-67 pubmed
  3. Wong P, Gall M, Bachovchin W, McCaughan G, Keane F, Gorrell M. Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma. Peptides. 2016;75:80-95 pubmed publisher
    ..These novel findings provide insights into the substrate specificity of FAP, which differs greatly from DPP4, and reveal a potential function for FAP in neuropeptide regulation within liver and cancer biology. ..
  4. Krause D, Piva T, Brown S, Ellem K. Characterization and localization of mitochondrial oligopeptidase (MOP) (EC 3.4.24.16) activity in the human cervical adenocarcinoma cell line HeLa. J Cell Biochem. 1997;66:297-308 pubmed
    ..The results obtained demonstrate the first recorded instance of this enzyme in human tissue cultured cells, and raise the issue of its function therein. ..
  5. Gu B, Bendall L, Wiley J. Adenosine triphosphate-induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases. Blood. 1998;92:946-51 pubmed
    ..However, different membrane metalloproteases seem to mediate the shedding of L-selectin and CD23. ..
  6. Mungall B, Kyaw Tanner M, Pollitt C. In vitro evidence for a bacterial pathogenesis of equine laminitis. Vet Microbiol. 2001;79:209-23 pubmed
    ..While many different causative agents have been evaluated in the past, the results of this study provide a unifying aetiological mechanism for the development of carbohydrate induced equine laminitis. ..
  7. Schirra H, Craik D. Structure and folding of potato type II proteinase inhibitors: circular permutation and intramolecular domain swapping. Protein Pept Lett. 2005;12:421-31 pubmed
    ..Structural studies give indications for the origins of this folding behaviour, and the evolution of the inhibitor family...
  8. Gardiner D, Trenholme K, Skinner Adams T, Stack C, Dalton J. Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin. J Biol Chem. 2006;281:1741-5 pubmed
    ..Overexpression of genes in malaria parasites would have general application in the identification and validation of targets for antimalarial drugs. ..
  9. Radley H, De Luca A, Lynch G, Grounds M. Duchenne muscular dystrophy: focus on pharmaceutical and nutritional interventions. Int J Biochem Cell Biol. 2007;39:469-77 pubmed

More Information

Publications11

  1. Whittington C, Papenfuss A, Locke D, Mardis E, Wilson R, Abubucker S, et al. Novel venom gene discovery in the platypus. Genome Biol. 2010;11:R95 pubmed publisher
    ..We have constructed and sequenced a cDNA library from an active platypus venom gland to identify the remaining components...
  2. Ong V, Marsh J, Lawrence A, Allan J, Timms P, Huston W. The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence. Front Cell Infect Microbiol. 2013;3:100 pubmed publisher
    ..Thus, CtHtrA is an essential protease with both replicative phase and stress condition functions for Chlamydia trachomatis. ..