Experts and Doctors on precipitin tests in United States

Summary

Locale: United States
Topic: precipitin tests

Top Publications

  1. Bikah G, Lynd F, Aruffo A, Ledbetter J, Bondada S. A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5. Int Immunol. 1998;10:1185-96 pubmed
    ..CD5L was expressed on activated splenic B cells, but not T cells, whereas its expression was constitutive on peritoneal B cells and on B lymphoma cell lines. ..
  2. Kim J, Kang J, Chan C. Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. J Cell Biol. 1999;145:1381-94 pubmed
    ..These genetic and biochemical studies indicate that Sli15 associates with Ipl1 to promote its function in chromosome segregation. ..
  3. Westphal R, Soderling S, Alto N, Langeberg L, Scott J. Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. EMBO J. 2000;19:4589-600 pubmed
    ..Thus, we propose a previously unrecognized function for WAVE-1 as an actin-associated scaffolding protein that recruits PKA and Abl. ..
  4. Smith J, Schaffner A, Hofmeister J, Hartman M, Wei G, Forsthoefel D, et al. ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. Mol Cell Biol. 2000;20:8026-34 pubmed
    ..Constitutive ets-2 activity may contribute to the pathology of me-v mice by increasing expression of genes like the Bcl-x gene that promote macrophage survival. ..
  5. Lu M, Holliday L, Zhang L, Dunn W, Gluck S. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. J Biol Chem. 2001;276:30407-13 pubmed
    ..The direct binding interaction between V-ATPase and aldolase may be a new mechanism for the regulation of the V-ATPase and may underlie the proximal tubule acidification defect in hereditary fructose intolerance. ..
  6. Samuels I, Seibenhener M, Neidigh K, Wooten M. Nerve growth factor stimulates the interaction of ZIP/p62 with atypical protein kinase C and targets endosomal localization: evidence for regulation of nerve growth factor-induced differentiation. J Cell Biochem. 2001;82:452-66 pubmed
    ..Collectively, these findings demonstrate that ZIP/p62 acts as a shuttling protein involved in routing activated aPKC to an endosomal compartment and is required for mediating NGF's biological properties. ..
  7. Belden W, Barlowe C. Role of Erv29p in collecting soluble secretory proteins into ER-derived transport vesicles. Science. 2001;294:1528-31 pubmed
    ..In vivo, export of gpalphaf from the ER was saturable and depended on the expression level of Erv29p. These results indicate that membrane receptors can link soluble cargo proteins to the COPII coat. ..
  8. Sano H, Liu S, Lane W, Piletz J, Lienhard G. Insulin receptor substrate 4 associates with the protein IRAS. J Biol Chem. 2002;277:19439-47 pubmed
    ..The domains of IRAS and IRS-4 responsible for the association of these two proteins were identified, and it was shown that IRAS also associates with IRS-1, IRS-2, and IRS-3. ..
  9. Liang Y, Li X, Rebar E, Li P, Zhou Y, Chen B, et al. Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility. J Biol Chem. 2002;277:20087-94 pubmed
    ..A dominant negative EPAS1 significantly reduces HS-1100 enhancer activity and VEGF-A levels in U87MG cells. Our results provide insight into the molecular mechanisms of VEGF-A up-regulation during cancer development. ..

More Information

Publications196 found, 100 shown here

  1. Bennin D, Don A, Brake T, McKenzie J, Rosenbaum H, Ortiz L, et al. Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. J Biol Chem. 2002;277:27449-67 pubmed
    ..The ability of cyclin G2 to inhibit cell cycle progression correlates with its ability to bind PP2A/B' and C subunits. Together, our findings suggest that cyclin G2-PP2A complexes inhibit cell cycle progression. ..
  2. Thomas D, Kaspar K, Taft W, Weng N, Rodenkirch L, Groblewski G. Identification of annexin VI as a Ca2+-sensitive CRHSP-28-binding protein in pancreatic acinar cells. J Biol Chem. 2002;277:35496-502 pubmed
  3. Marmorstein L, Munier F, Arsenijevic Y, Schorderet D, McLaughlin P, Chung D, et al. Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration. Proc Natl Acad Sci U S A. 2002;99:13067-72 pubmed
    ..These data present evidence that misfolding and aberrant accumulation of EFEMP1 may cause drusen formation and cellular degeneration and play an important role in the etiology of both ML and AMD. ..
  4. Person R, Li F, Duan Z, Benson K, Wechsler J, Papadaki H, et al. Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat Genet. 2003;34:308-12 pubmed
  5. Powell D, Rane M, Joughin B, Kalmukova R, Hong J, Tidor B, et al. Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol. 2003;23:5376-87 pubmed
    ..These data suggest that MAPKAPK2-mediated phosphorylation regulates 14-3-3zeta functions, and this MAPKAPK2 activity may represent a novel pathway mediating p38 MAPK-dependent inflammation. ..
  6. Massillon D, Arinze I, Xu C, Bone F. Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. J Biol Chem. 2003;278:40694-701 pubmed
  7. Wang Q, Pfeiffer G, Gaarde W. Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cells. J Biol Chem. 2003;278:47731-43 pubmed
  8. Sundararaj K, Wood R, Ponnusamy S, Salas A, Szulc Z, Bielawska A, et al. Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem. 2004;279:6152-62 pubmed
  9. Osman A, Niles E, LoVerde P. Expression of functional Schistosoma mansoni Smad4: role in Erk-mediated transforming growth factor beta (TGF-beta) down-regulation. J Biol Chem. 2004;279:6474-86 pubmed
    ..SmSmad4 was shown to complement a human Smad4 deficiency through the restoration of TGF-beta-responsiveness in MDA-MB-468 breast cancer cells. ..
  10. Toda S, Alguacil L, Kalivas P. Repeated cocaine administration changes the function and subcellular distribution of adenosine A1 receptor in the rat nucleus accumbens. J Neurochem. 2003;87:1478-84 pubmed
    ..These data suggest that the sorting and recycling of A1 receptors is dysregulated in the nucleus accumbens as the consequence of repeated cocaine administration. ..
  11. Goel A, Janknecht R. Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu. J Biol Chem. 2004;279:14909-16 pubmed
    ..Thus, oncogenic HER2/Neu and ACTR may synergize to orchestrate mammary tumorigenesis through the dysregulation of the transcription factor ER81 and its target genes. ..
  12. Richards D, Bai J, Chapman E. Two modes of exocytosis at hippocampal synapses revealed by rate of FM1-43 efflux from individual vesicles. J Cell Biol. 2005;168:929-39 pubmed
  13. Johnson J, Beito T, Krco C, Toft D. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol Cell Biol. 1994;14:1956-63 pubmed
    ..These antibodies specifically immunoprecipitate p23 in complex with hsp90 in all tissues tested and can be used to immunoaffinity isolate progesterone receptor complexes from chicken oviduct cytosol. ..
  14. Wong E, Schaefer A, Landreth G, Lemmon V. Casein kinase II phosphorylates the neural cell adhesion molecule L1. J Neurochem. 1996;66:779-86 pubmed
    ..These data show that CKII is associated with and able to phosphorylate L1. This phosphorylation may be important in regulating certain aspects of L1 function, such as adhesivity or signal transduction. ..
  15. Gray P, Tibbs V, Catterall W, Murphy B. Identification of a 15-kDa cAMP-dependent protein kinase-anchoring protein associated with skeletal muscle L-type calcium channels. J Biol Chem. 1997;272:6297-302 pubmed
    ..Together, these findings demonstrate a physical link between PKA and the calcium channel and suggest that AKAP-15 may mediate their interaction. ..
  16. Singh D, Chebloune Y, Mselli Lakhal L, Karr B, Narayan O. Ovine lentivirus-infected macrophages mediate productive infection in cell types that are not susceptible to infection with cell-free virus. J Gen Virol. 1999;80 ( Pt 6):1437-44 pubmed
    ..This strategy could be one of the mechanisms involved in the escape from immune surveillance and establishment of persistent infection in infected animals...
  17. Chen Z, Miao Z, Vetter M, Dulin N, Liu S, Che D, et al. Molecular cloning of a regulatory protein for membrane-bound guanylate cyclase GC-A. Biochem Biophys Res Commun. 2000;278:106-11 pubmed
    ..Coimmunoprecipitation experiments indicate that GCRP associates with GC-A in the presence of ANF. These results suggest that ANF induces the association of GCRP with GC-A and this association contributes to the activation of GC-A. ..
  18. Bunger M, Moran S, Glover E, Thomae T, Lahvis G, Lin B, et al. Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem. 2003;278:17767-74 pubmed
    ..Taken in sum, these data support a model where most, if not all, of AHR-regulated biology requires nuclear localization. ..
  19. Baran C, Tridandapani S, Helgason C, Humphries R, Krystal G, Marsh C. The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. J Biol Chem. 2003;278:38628-36 pubmed
    ..These data provide the first evidence of the involvement of both SHIP-1 and Lyn in the negative regulation of M-CSF-R-induced Akt activation. ..
  20. Zhao X, Carnevale K, Cathcart M. Human monocytes use Rac1, not Rac2, in the NADPH oxidase complex. J Biol Chem. 2003;278:40788-92 pubmed
    ..This finding suggests that it may be possible to selectively interfere with either monocyte or neutrophil NADPH oxidase activity, thereby selectively targeting chronic versus acute inflammatory processes. ..
  21. Dicioccio R, Darby J, Willems P. Abnormal expression of alpha-L-fucosidase in lymphoid cell lines of fucosidosis patients. Biochem Genet. 1989;27:279-90 pubmed
    ..In summary, the fucosidosis mutation(s) affected the catalytic activity, quantity, and extracellular release of alpha-L-fucosidase as expressed by lymphoid cells...
  22. Yahr T, Wickner W. Evaluating the oligomeric state of SecYEG in preprotein translocase. EMBO J. 2000;19:4393-401 pubmed
    ..These studies suggest that the active form of preprotein translocase is monomeric SecYEG. ..
  23. Keenan Curtis K, Kane P. Novel vacuolar H+-ATPase complexes resulting from overproduction of Vma5p and Vma13p. J Biol Chem. 2002;277:2716-24 pubmed
    ..Overproduced Vma5p associated with cytosolic V(1) complexes; this association may cause the lethality. ..
  24. Vassilieva E, Stirewalt V, Jakobs C, Frigaard N, Inoue Sakamoto K, Baker M, et al. Subcellular localization of chlorosome proteins in Chlorobium tepidum and characterization of three new chlorosome proteins: CsmF, CsmH, and CsmX. Biochemistry. 2002;41:4358-70 pubmed
  25. Albrecht D, Froehner S. DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes. J Biol Chem. 2004;279:7014-23 pubmed
    ..These results expand the role of dystrobrevin and the dystrophin complex in membrane signaling and disease. ..
  26. Kamikura D, Cooper J. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003;17:2798-811 pubmed
    ..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway. ..
  27. Qi X, Borowicz S, Pramanik R, Schultz R, Han J, Chen G. Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells. J Biol Chem. 2004;279:6769-77 pubmed
    ..Together, our studies reveal a novel function of ER in stress response by modification of c-Jun activity. ..
  28. Clark K, Oelke A, Johnson M, Eilert K, Simpson P, Todd S. CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner. J Biol Chem. 2004;279:19401-6 pubmed
    ..These finding suggest that CD81 signaling events could be mediated by 14-3-3 adapter proteins, and these signals may be dependent on cellular redox. ..
  29. Zainelli G, Ross C, Troncoso J, Fitzgerald J, Muma N. Calmodulin regulates transglutaminase 2 cross-linking of huntingtin. J Neurosci. 2004;24:1954-61 pubmed
    ..Inhibiting the interaction of calmodulin with transglutaminase and huntingtin protein could decrease cross-linking and diminish huntingtin aggregate formation in the HD brain. ..
  30. Ammanamanchi S, Brattain M. Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells. J Biol Chem. 2004;279:32620-5 pubmed
    ..Significantly, SAHA-mediated RI regeneration restored the TGF-beta response in breast cancer cells. ..
  31. Nyborg A, Kornilova A, Jansen K, Ladd T, Wolfe M, Golde T. Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor. J Biol Chem. 2004;279:15153-60 pubmed
    ..Collectively these data suggest that SPP exists in vivo as a functional dimer. ..
  32. Chiu S, Lejeune F, Ranganathan A, Maquat L. The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. Genes Dev. 2004;18:745-54 pubmed
    ..Polysome profiles indicate that CBP80-bound mRNAs are translated less efficiently than their eIF4E-bound counterparts. ..
  33. Sandberg E, Sayeski P. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. J Biol Chem. 2004;279:34547-52 pubmed
    ..Furthermore, this report identifies Jak2 as a potential therapeutic target in vascular diseases in which vascular smooth muscle cell apoptosis contributes to pathological progression. ..
  34. Jiang H, Daniels P, Andrews G. Putative zinc-sensing zinc fingers of metal-response element-binding transcription factor-1 stabilize a metal-dependent chromatin complex on the endogenous metallothionein-I promoter. J Biol Chem. 2003;278:30394-402 pubmed
    ..During the course of these studies, it was discovered that mouse MTF-1 is polymorphic. The impact of these polymorphisms on MTF-1 metalloregulatory functions is discussed. ..
  35. Jackson J, Young M. Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants. Clin Exp Metastasis. 2003;20:357-64 pubmed
  36. Leach T, Mazzeo M, Chotkowski H, Madigan J, Wotring M, Glaser R. Histone H2A.Z is widely but nonrandomly distributed in chromosomes of Drosophila melanogaster. J Biol Chem. 2000;275:23267-72 pubmed
    ..Of the sequences assayed, H2Av was least abundant on 1. 688 satellite sequences and most abundant on the hsp70 genes. Finally, transcription caused, to an equivalent extent, both H2Av and H2A to be less tightly associated with DNA. ..
  37. Minnear F, Patil S, Bell D, Gainor J, Morton C. Platelet lipid(s) bound to albumin increases endothelial electrical resistance: mimicked by LPA. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1337-44 pubmed
    ..These findings indicate that a bioactive lipid(s), possibly LPA, released from platelets and subsequently bound to albumin forms an active complex that decreases endothelial permeability...
  38. Fang X, Han H, Stamatoyannopoulos G, Li Q. Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression. J Biol Chem. 2004;279:5444-9 pubmed
    ..Our data also suggest that it is unlikely that transcriptional stimulation by the CCAAT box is exerted through direct protein-protein interaction between NF-Y and TBP. ..
  39. Carnegie G, Smith F, McConnachie G, Langeberg L, Scott J. AKAP-Lbc nucleates a protein kinase D activation scaffold. Mol Cell. 2004;15:889-99 pubmed
    ..This configuration illustrates the utility of kinase anchoring as a mechanism to constrain the action of broad-spectrum enzymes. ..
  40. Spiegelman V, Tang W, Chan A, Igarashi M, Aaronson S, Sassoon D, et al. Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling. J Biol Chem. 2002;277:36624-30 pubmed
    ..These data link the induction of HOS in proliferating cells with mitogen-signaling-dependent inhibition of cell differentiation and promotion of cell transformation. ..
  41. Sridharan D, Brown M, Lambert W, McMahon L, Lambert M. Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links. J Cell Sci. 2003;116:823-35 pubmed
    ..These studies suggest that an important role for alphaSpIISigma* in the nucleus is to act as a scaffold, aiding in recruitment and alignment of repair proteins at sites of damage. ..
  42. Xu Z, Williams B. The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR. Mol Cell Biol. 2000;20:5285-99 pubmed
    ..Taken together, our data indicate that PKR can modulate PP2A activity by phosphorylating B56alpha to regulate cellular activities. ..
  43. Pan S, An P, Zhang R, He X, Yin G, Min W. Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis. Mol Cell Biol. 2002;22:7512-23 pubmed
    ..While most TNF actions have been attributed to TNFR1, our studies demonstrate that Etk is a TNFR2-specific kinase involved in TNF-induced angiogenic events. ..
  44. Swaan P, Knoell D, Helsper F, Wewers M. Sequential processing of human ProIL-1beta by caspase-1 and subsequent folding determined by a combined in vitro and in silico approach. Pharm Res. 2001;18:1083-90 pubmed
    ..These findings may facilitate the development of novel pharmacological agents that control posttranslational proIL-1beta modification, thereby preventing excessive production of this potent inflammatory cytokine. ..
  45. Liedtke C, Yun C, Kyle N, Wang D. Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor. J Biol Chem. 2002;277:22925-33 pubmed
    ..The results indicate the RACK1 binds PKC epsilon and NHERF1, thus serving as a scaffold protein to anchor the enzyme in proximity to CFTR. ..
  46. Kemp H, Sprague G. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Mol Cell Biol. 2003;23:1750-63 pubmed
    ..We conclude that the FAR3-dependent arrest pathway is functionally distinct from that which employs FAR1. ..
  47. Dhar S, Lynn B, Daosukho C, St Clair D. Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene. J Biol Chem. 2004;279:28209-19 pubmed
    ..These results identify NPM as a partner of the NF-kappaB transcription complex in the induction of MnSOD by phorbol 12-myristate 13-acetate and cytokines. ..
  48. McMahon L, Walsh C, Lambert M. Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex. J Biol Chem. 1999;274:32904-8 pubmed
    ..alphaSpIISigma* may thus act as a scaffold to align or enhance interactions between FA proteins and proteins involved in DNA repair. These results suggest that FA represents a disorder in which there is a deficiency in alphaSpIISigma*. ..
  49. Takeishi Y, Huang Q, Wang T, Glassman M, Yoshizumi M, Baines C, et al. Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning. J Mol Cell Cardiol. 2001;33:1989-2005 pubmed
    ..These data suggest important roles for Src family kinases and adenosine in mediating preconditioning, and suggest specific roles for individual MAP kinases in preconditioning. ..
  50. Gopalakrishnan B, Wang W, Greenspan D. Biosynthetic processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer. J Biol Chem. 2004;279:30904-12 pubmed
  51. Miyakawa Y, Drachman J, Gallis B, Kaushansky A, Kaushansky K. A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl. J Biol Chem. 2000;275:32214-9 pubmed
    ..However, the mutation of Ser-18 to Ala nearly abrogates TPO-induced proliferation and co-precipitation of JAK2 with Mpl. This study provides the first systematic analysis of the role of Ser residues in c-Mpl signaling. ..
  52. Shadiack A, Hart R, Carlson C, Jonakait G. Interleukin-1 induces substance P in sympathetic ganglia through the induction of leukemia inhibitory factor (LIF). J Neurosci. 1993;13:2601-9 pubmed
    ..In addition, steady-state levels of mRNA coding for LIF are increased by IL-1 treatment of SCG. These data suggest that LIF, induced by IL-1, may ultimately be responsible for the IL-1 induction of SP. ..
  53. Wee S, Wang W, Farr A, Nelson A, Patel D, Haynes B, et al. Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues. Cell Immunol. 1994;158:353-64 pubmed
    ..Using CD6-Rg we were able to show that murine thymus, lymph nodes, and skin express high levels of CD6 ligand(s) and that CD6-Rg bound to a murine thymic epithelial cell line and to cultured human epidermal keratinocytes. ..
  54. Ford H, Silver D, Kachar B, Sellers J, Zain S. Effect of Mts1 on the structure and activity of nonmuscle myosin II. Biochemistry. 1997;36:16321-7 pubmed
    ..The data demonstrate an effect of Mts1 on both myosin structure and function, and suggest a route through which Mts1 affects motility as well as metastasis. ..
  55. Jelacic T, Kennedy M, Wickman K, Clapham D. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. J Biol Chem. 2000;275:36211-6 pubmed
    ..These data indicate that functional GIRK channels composed of GIRK2 and GIRK3 subunits exist in brain. ..
  56. Naik U, Naik M. Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen. Blood. 2003;102:1355-62 pubmed
    ..These data suggest that formation of the CIB-GPIIb/IIIa complex may be necessary for initiation of downstream signaling events, such as ADP secretion, that lead to platelet spreading. ..
  57. Ogden S, Ascano M, Stegman M, Suber L, Hooper J, Robbins D. Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr Biol. 2003;13:1998-2003 pubmed
    ..This work fills in the last major gap in our understanding of the Hh signal transduction pathway by suggesting that no intermediate signal is required to connect Smo to the HSC. ..
  58. Panigrahi A, Schnaufer A, Carmean N, Igo R, Gygi S, Ernst N, et al. Four related proteins of the Trypanosoma brucei RNA editing complex. Mol Cell Biol. 2001;21:6833-40 pubmed publisher
    ..Recombinant TbMP63 and TbMP52 coimmunoprecipitate. These results indicate that these four proteins are components of the RNA editing complex and that TbMP63 and TbMP52 can interact...
  59. Bayer A, Heidkamp M, Howes A, Heller Brown J, Byron K, Samarel A. Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes. J Mol Cell Cardiol. 2003;35:1121-33 pubmed
    ..These data demonstrate that ET-induced PYK2 activation is Gq, PKC epsilon, and Src dependent, describing a distinct signaling pathway leading to agonist-induced PYK2 activation in cardiomyocytes. ..
  60. Chen F, Harrison L. Ciglitazone induces early cellular proliferation and NF-kappaB transcriptional activity in colon cancer cells through p65 phosphorylation. Int J Biochem Cell Biol. 2005;37:645-54 pubmed
    ..These data suggest that the early proliferative phase of PPARgamma ligand exposure is associated with activation of NF-kappaB by p65 phosphorylation and cofactor recruitment and not through increased DNA binding. ..
  61. Li Z, Na X, Wang D, Schoen S, Messing E, Wu G. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem. 2002;277:4656-62 pubmed
    ..Targeted degradation of VDU1 by pVHL could be crucial for regulating the ubiquitin-proteasome degradation pathway. ..
  62. Chen X, Zhang B, Fischer J. A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets. Genes Dev. 2002;16:289-94 pubmed
    ..The results show definitively that Lqf is the key substrate of Faf in the eye; Lqf concentration is Faf-dependent, Lqf is ubiquitinated in vivo and deubiquitinated by Faf, and Lqf and Faf interact physically. ..
  63. Wells J, Graveel C, Bartley S, Madore S, Farnham P. The identification of E2F1-specific target genes. Proc Natl Acad Sci U S A. 2002;99:3890-5 pubmed
    ..Thus, whereas E2F1 may share redundant functions in cell growth control with other E2F family members, it may also play an important biological role distinct from the other E2Fs. ..
  64. Kemmer K, Corless C, Fletcher J, McGreevey L, Haley A, Griffith D, et al. KIT mutations are common in testicular seminomas. Am J Pathol. 2004;164:305-13 pubmed
    ..These findings suggest that activating KIT mutations may contribute to tumorigenesis in a subset of seminomas, but are not involved in NSGCT...
  65. Chu X, Tong Q, Cheung J, Wozney J, Conrad K, Mazack V, et al. Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx. J Biol Chem. 2004;279:10514-22 pubmed
    ..These data demonstrate that specific TRPCs are expressed in primary erythroid cells and that two of these channels, TRPC2 and TRPC6, can interact to modulate calcium influx stimulated by erythropoietin. ..
  66. Cullen P, Sabbagh W, Graham E, Irick M, van Olden E, Neal C, et al. A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev. 2004;18:1695-708 pubmed
    ..Taken together, our data suggest that Msb2 is a signaling mucin that interacts with general components, such as Cdc42 and Sho1, to promote their function in the FG pathway. ..
  67. Kasyapa C, Kunapuli P, Cowell J. HSPA1A is an important regulator of the stability and function of ZNF198 and its oncogenic derivative, ZNF198-FGFR1. J Cell Biochem. 2007;102:1308-17 pubmed
    ..These observations suggest an important role for HSPA1A in ZNF198 and ZNF198-FGFR1 mediated cellular function. ..
  68. Garden G, Hartlage Rübsamen M, Rubel E, Bothwell M. Protein masking of a ribosomal RNA epitope is an early event in afferent deprivation-induced neuronal death. Mol Cell Neurosci. 1995;6:293-310 pubmed
    ..Immunoprecipitation experiments confirmed that the Y10B antibody recognizes a specific rRNA sequence without posttranscriptional modification. ..
  69. Johnston S, Liu X, Zuo F, Eisenbraun T, Wiley S, Kraus R, et al. Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol Endocrinol. 1997;11:342-52 pubmed
    ..Thus, hERR alpha 1 may play a role in the response of some genes to estrogen via heterodimerization with ERs or competition with ERs for binding to EREs. ..
  70. Eklund E, Jalava A, Kakar R. Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines. J Biol Chem. 2000;275:20117-26 pubmed
    ..Therefore, these investigations identify the CYBB gene as a potential target for HoxA10 and define repression of genes expressed in mature myeloid cells as a novel role for HoxA10 during myeloid differentiation. ..
  71. Ezashi T, Ghosh D, Roberts R. Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4. Mol Cell Biol. 2001;21:7883-91 pubmed
    ..These findings provide further evidence that the developmental switch to the trophectoderm is accompanied by the loss of Oct-4 silencing of key genes. ..
  72. Ryseck R, Macdonald Bravo H, Mattei M, Bravo R. Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ. 1991;2:225-33 pubmed
    ..The fisp-12 gene maps to the [10A3-10B1] region of the murine genome. ..
  73. Clyman R, Turner D, Kramer R. An alpha 1/beta 1-like integrin receptor on rat aortic smooth muscle cells mediates adhesion to laminin and collagen types I and IV. Arteriosclerosis. 1990;10:402-9 pubmed
    ..By using 3A3 to inhibit only the 185/120 kD receptor, we suggest that these other receptors also can be used by rat aortic smooth muscle cells to attach to laminin and collagen type I. ..
  74. Weinmann A, Bartley S, Zhang T, Zhang M, Farnham P. Use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol Cell Biol. 2001;21:6820-32 pubmed
  75. Cox E, Bennin D, Doan A, O TOOLE T, Huttenlocher A. RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site. Mol Biol Cell. 2003;14:658-69 pubmed
    ..Together, these findings suggest that RACK1 regulates adhesion, protrusion, and chemotactic migration through its interaction with Src. ..
  76. Durso R, Fisher A, Albright Frey T, Reese J. Analysis of TAF90 mutants displaying allele-specific and broad defects in transcription. Mol Cell Biol. 2001;21:7331-44 pubmed
  77. Kotadia B, Ravindranath T, Choudhry M, Haque F, Al Ghoul W, Sayeed M. Effects of pentoxyfylline on mesenteric lymph node T-cells in a rat model of thermal injury. Shock. 2003;20:517-20 pubmed
    ..These findings altogether suggested that PTX treatment attenuate T cell suppression in burn-injured rats and that the effects of PTX are mediated via modulating P59 fyn and Ca2+ signaling. ..
  78. Farr G, Ferkey D, Yost C, Pierce S, Weaver C, Kimelman D. Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol. 2000;148:691-702 pubmed
    ..These results contribute to our growing understanding of how GSK-3 regulation in the early embryo leads to regional differences in beta-catenin levels and establishment of the dorsal axis. ..
  79. Shareef M, King C, Damaj M, Badagu R, Huang D, Kellum R. Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing. Mol Biol Cell. 2001;12:1671-85 pubmed publisher
    ..Moreover, the gene encoding HP1/ORC-associated protein was found to display reciprocal dose-dependent variegation modifier phenotypes, similar to those for mutants in HP1 and the ORC 2 subunit...
  80. Komarnitsky P, Klebanow E, Weil P, Denis C. ADR1-mediated transcriptional activation requires the presence of an intact TFIID complex. Mol Cell Biol. 1998;18:5861-7 pubmed
    ..These results indicate that ADR1 physically associates with TFIID and that its ability to activate transcription requires an intact TFIID complex. ..
  81. Mennella T, Klinkenberg L, Zitomer R. Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein. Eukaryot Cell. 2003;2:1288-303 pubmed
    ..These findings suggest that the repression of different regulons or genes may invoke different mechanisms. ..
  82. Wayner E, Carter W, Piotrowicz R, Kunicki T. The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platele. J Cell Biol. 1988;107:1881-91 pubmed
    ..These results show that multiple ECMRs function in combination to mediate cell adhesion to complex EMC templates and predicts that variation in ECM composition and ECMR expression may direct cell localization to specific tissue domains. ..
  83. Schoborg R. Analysis of caprine arthritis encephalitis virus (CAEV) temporal gene expression in infected cells. Virus Res. 2002;90:37-46 pubmed
    ..These data indicate that a temporal shift from viral non-structural to structural gene expression occurs in CAEV infected GSM cells...
  84. Xing H, Mayhew C, Cullen K, Park Sarge O, Sarge K. HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. J Biol Chem. 2004;279:10551-5 pubmed
    ..Thus, HSF1 regulates HSP gene expression at not one but two different steps of the expression pathway, functioning both as a transcription factor and a polyadenylation stimulatory factor. ..
  85. Gilinger G, Luo H, Bellofatto V. In vivo transcription analysis utilizing chromatin immunoprecipation reveals a role for trypanosome transcription factor PBP-1 in RNA polymerase III-dependent transcription. Mol Biochem Parasitol. 2004;134:169-73 pubmed
  86. Leung T, Hoffmann A, Baltimore D. One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell. 2004;118:453-64 pubmed
    ..This suggests that binding sites may impart a specific configuration to bound transcription factors. ..
  87. Porfiri E, Rubinfeld B, Albert I, Hovanes K, Waterman M, Polakis P. Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. Oncogene. 1997;15:2833-9 pubmed
    ..The results suggest that a cancer pathway driven by wnt-1, or mutant forms of beta-catenin, may involve the formation of a persistent transcriptionally active complex of beta-catenin and LEF1. ..
  88. Cavet M, Lehoux S, Berk B. 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity. J Biol Chem. 2003;278:18376-83 pubmed
  89. Vainauskas S, Menon A. A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase. J Biol Chem. 2004;279:6540-5 pubmed
    ..We suggest that the putative dynamic hinge created by the proline residue provides a structural basis for the interaction of GPI with GPIT. ..
  90. Thomas E, Connelly R, Pennathur S, Dubrovsky L, Haffar O, Bukrinsky M. Anti-idiotypic antibody to the V3 domain of gp120 binds to vimentin: a possible role of intermediate filaments in the early steps of HIV-1 infection cycle. Viral Immunol. 1996;9:73-87 pubmed
    ..These data suggest that vimentin may participate in the early steps of HIV-1 replication, perhaps during the uptake of HIV-1 preintegration complexes into the nuclear compartment. ..
  91. He Q, Meiri K. Isolation and characterization of detergent-resistant microdomains responsive to NCAM-mediated signaling from growth cones. Mol Cell Neurosci. 2002;19:18-31 pubmed
    ..Our results provide evidence for NCAM-mediated signaling in DRMs and suggest that the DRMs responsible for fyn and PKC/GAP-43-mediated NCAM signaling are structurally distinct and differentially distributed in growth cones. ..
  92. Liu X, Tesfai J, Evrard Y, Dent S, Martinez E. c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem. 2003;278:20405-12 pubmed
    ..Thus, TRRAP might function as an adaptor within the STAGA complex, which helps recruit GCN5 HAT activity to Myc during transcription activation. ..