Experts and Doctors on polymers in Switzerland


Locale: Switzerland
Topic: polymers

Top Publications

  1. Eglin D, Griffon S, Alini M. Thiol-containing degradable poly(thiourethane-urethane)s for tissue engineering. J Biomater Sci Polym Ed. 2010;21:477-91 pubmed publisher
    ..The surface thiol groups add the prospect of further functionalization. This is an important benefit compared to biodegradable poly(urethane)s that usually present low biological activity. ..
  2. Siepe S, Herrmann W, Borchert H, Lueckel B, Kramer A, Ries A, et al. Microenvironmental pH and microviscosity inside pH-controlled matrix tablets: an EPR imaging study. J Control Release. 2006;112:72-8 pubmed
    ..EPRI, a novel approach for monitoring pH(M) and tau(R) non-invasively and spatially resolved, was used successfully for the optimization of an pH-controlled formulation. ..
  3. Montagne F, Blondiaux N, Bojko A, Pugin R. Molecular transport through nanoporous silicon nitride membranes produced from self-assembling block copolymers. Nanoscale. 2012;4:5880-6 pubmed publisher
    ..These new silicon nanosieves offer a relevant technological alternative to commercially available ultra- and microfiltration membranes for conducting high resolution biomolecular separations at small scales. ..
  4. Ruckstuhl T, Winterflood C, Seeger S. Supercritical angle fluorescence immunoassay platform. Anal Chem. 2011;83:2345-50 pubmed publisher
    ..5 pg/mL) and the linear range covered 3 orders of magnitude. The developed technology is also adaptable to well plates and has great potential of replacing the work-intensive and time-consuming enzyme-linked immunosorbant assay (ELISA). ..
  5. Engelhardt E, Micol L, Houis S, Wurm F, Hilborn J, Hubbell J, et al. A collagen-poly(lactic acid-co-?-caprolactone) hybrid scaffold for bladder tissue regeneration. Biomaterials. 2011;32:3969-76 pubmed publisher
    ..Collagen-PLAC hybrids have potential for bladder tissue regeneration, as they show efficient cell seeding, proliferation, and good mechanical properties. ..
  6. Silvan U, Boiteux C, Sütterlin R, Schroeder U, Mannherz H, Jockusch B, et al. An antiparallel actin dimer is associated with the endocytic pathway in mammalian cells. J Struct Biol. 2012;177:70-80 pubmed publisher
    ..Taken together, our results strongly support a functional role of LD in the patterning of supramolecular actin assemblies in mammalian cells. ..
  7. Coullerez G, Seeberger P, Textor M. Merging organic and polymer chemistries to create glycomaterials for glycomics applications. Macromol Biosci. 2006;6:634-47 pubmed
  8. Onaca Fischer O, Liu J, Inglin M, Palivan C. Polymeric nanocarriers and nanoreactors: a survey of possible therapeutic applications. Curr Pharm Des. 2012;18:2622-43 pubmed
  9. Shiao T, Rej R, Rose M, Pavan G, Roy R. Synthesis of Dense and Chiral Dendritic Polyols Using Glyconanosynthon Scaffolds. Molecules. 2016;21:448 pubmed publisher
    ..These were further modified by thiol-ene and thiol-yne click reactions with alcohols to provide dendritic polyols. Molecular dynamic simulation supported the assumption that the resulting polyols have a dense structure. ..

More Information


  1. Waeckerle Men Y, Allmen E, Gander B, Scandella E, Schlosser E, Schmidtke G, et al. Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells. Vaccine. 2006;24:1847-57 pubmed
    ..In conclusion, antigen delivery via PLGA-MS markedly enhanced the duration of antigen presentation by human MoDC and the potency of DC-based vaccination. ..
  2. Tanner P, Baumann P, Enea R, Onaca O, Palivan C, Meier W. Polymeric vesicles: from drug carriers to nanoreactors and artificial organelles. Acc Chem Res. 2011;44:1039-49 pubmed publisher
    ..The combination of polymer vesicles and biological entities will serve as tools to improve the observation and treatment of pathological events and the overall condition of the patient. ..
  3. Felber A, Dufresne M, Leroux J. pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates. Adv Drug Deliv Rev. 2012;64:979-92 pubmed publisher
  4. Margalith I, Suter C, Ballmer B, Schwarz P, Tiberi C, Sonati T, et al. Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates. J Biol Chem. 2012;287:18872-87 pubmed publisher
    ..Therefore, LCPs represent a novel class of antiprion agents whose mode of action appears to rely on hyperstabilization, rather than destabilization, of PrP(Sc) deposits. ..
  5. Zbinden R, Piccolo R, Heg D, Roffi M, Kurz D, Muller O, et al. Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent Versus Durable-Polymer Everolimus-Eluting Stent for Percutaneous Coronary Revascularization: 2-Year Results of the BIOSCIENCE Trial. J Am Heart Assoc. 2016;5:e003255 pubmed publisher
    ..48, 95% CI 0.23-0.99, P=0.043, Pinteraction=0.026). Comparable safety and efficacy profiles of BP-SES and DP-EES were maintained throughout 2 years of follow-up. URL: Unique identifier: NCT01443104. ..
  6. Schmoelz W, Mayr R, Schlottig F, Ivanovic N, Hörmann R, Goldhahn J. Ultrasound melted polymer sleeve for improved screw anchorage in trabecular bone--A novel screw augmentation technique. Clin Biomech (Bristol, Avon). 2016;33:79-83 pubmed publisher
  7. Stojkovic M, Uda N, Brodmann P, Popovic M, Hauser P. Determination of PCR products by CE with contactless conductivity detection. J Sep Sci. 2012;35:3509-13 pubmed publisher
    ..PCR amplified DNA fragments of different sizes obtained from different bacterial plasmid templates as well as a fragment from genomic DNA of genetically modified soybeans could be successfully identified. ..
  8. Krehel M, Rossi R, Bona G, Scherer L. Characterization of flexible copolymer optical fibers for force sensing applications. Sensors (Basel). 2013;13:11956-68 pubmed publisher
    ..Moreover, the high yield strength (0.0039-0.0054 GPa) and flexibility make these fibres very attractive candidates for integration into textiles to form wearable sensors, medical textiles or even computing systems. ..
  9. Heuking S, Iannitelli A, Di Stefano A, Borchard G. Toll-like receptor-2 agonist functionalized biopolymer for mucosal vaccination. Int J Pharm. 2009;381:97-105 pubmed publisher
    ..However, (1)H NMR and FTIR spectroscopy demonstrated clearly that successful grafting took place. Based upon these results, this new TLR-2 functionalized biopolymer merits further investigations as material for vaccine delivery systems. ..
  10. Vasdekis A, O Neil C, Hubbell J, Psaltis D. Microfluidic assays for DNA manipulation based on a block copolymer immobilization strategy. Biomacromolecules. 2010;11:827-31 pubmed publisher
  11. Reddy S, Swartz M, Hubbell J. Targeting dendritic cells with biomaterials: developing the next generation of vaccines. Trends Immunol. 2006;27:573-9 pubmed
    ..Here, we review the latest advances in biomaterial drug vehicles, such as polymer microparticles and nanoparticles, and liposomes, that are being used to target DCs in new strategies for vaccination. ..
  12. Rakhmatullina E, Meier W. Solid-supported block copolymer membranes through interfacial adsorption of charged block copolymer vesicles. Langmuir. 2008;24:6254-61 pubmed publisher
    ..The thickness of the copolymer membrane on mica was comparable to the thickness of phospholipid bilayers. ..
  13. Najer A, Wu D, Vasquez D, Palivan C, Meier W. Polymer nanocompartments in broad-spectrum medical applications. Nanomedicine (Lond). 2013;8:425-47 pubmed publisher
    ..The authors present the latest concepts and examples based on the encapsulation/entrapment of biomolecules (e.g., enzymes and proteins) for the development of active nanosystems for application in the medical domain. ..
  14. Sigg S, Seidi F, Renggli K, Silva T, Kali G, Bruns N. Horseradish peroxidase as a catalyst for atom transfer radical polymerization. Macromol Rapid Commun. 2011;32:1710-5 pubmed publisher
    ..Conversion, M(n) and PDI depend on the pH and on the concentration of the reducing agent, sodium ascorbate. HRP is stable during the polymerization and does not unfold or form conjugates. ..
  15. Adler C, Schönenberger M, Teleki A, Kuentz M. Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion. Int J Pharm. 2016;499:90-100 pubmed publisher
    ..The novel delivery system appeared to be especially promising for the formulation of oral compounds that exhibit both high crystal energy and lipophilicity. ..
  16. Gunkel Grabole G, Sigg S, Lomora M, Lörcher S, Palivan C, Meier W. Polymeric 3D nano-architectures for transport and delivery of therapeutically relevant biomacromolecules. Biomater Sci. 2015;3:25-40 pubmed publisher
    ..It is focused on their function as a carrier for biologically active macromolecules, highlighting seminal examples from the current literature and pointing out the remaining and upcoming challenges in this important area of research. ..
  17. Supper S, Anton N, Seidel N, Riemenschnitter M, Schoch C, Vandamme T. Rheological study of chitosan/polyol-phosphate systems: influence of the polyol part on the thermo-induced gelation mechanism. Langmuir. 2013;29:10229-37 pubmed publisher
    ..The new results presented in this study show that increasing the size of the polyol part prevents the interactions between the chitosan chains, strongly influencing the gelling process. ..
  18. Nilsson K, Ikenberg K, Aslund A, Fransson S, Konradsson P, Rocken C, et al. Structural typing of systemic amyloidoses by luminescent-conjugated polymer spectroscopy. Am J Pathol. 2010;176:563-74 pubmed publisher
    ..We conclude that LCP spectroscopy is a sensitive and powerful tool for identifying and characterizing amyloid deposits. ..
  19. Roshan Ghias A, Terrier A, Bourban P, Pioletti D. In vivo cyclic loading as a potent stimulatory signal for bone formation inside tissue engineering scaffold. Eur Cell Mater. 2010;19:41-9 pubmed
    ..At week 13, the BV was then significantly higher in the loaded scaffolds. ..
  20. Kobel S, Limacher M, Gobaa S, Laroche T, Lutolf M. Micropatterning of hydrogels by soft embossing. Langmuir. 2009;25:8774-9 pubmed publisher
    ..Confining the stem cells to their microwells allowed for efficient quantification of their growth potential during in vitro culturing. ..
  21. Wang P, Zakeeruddin S, Moser J, Nazeeruddin M, Sekiguchi T, Grätzel M. A stable quasi-solid-state dye-sensitized solar cell with an amphiphilic ruthenium sensitizer and polymer gel electrolyte. Nat Mater. 2003;2:402-7 pubmed
    ..The present findings should foster widespread practical application of dye-sensitized solar cells. ..
  22. Lombardi T, Samson J, Plantier F, Husson C, Kuffer R. Orofacial granulomas after injection of cosmetic fillers. Histopathologic and clinical study of 11 cases. J Oral Pathol Med. 2004;33:115-20 pubmed
    ..Increasing demand for orofacial tissue augmentation makes pathologists face new, and sometimes, puzzling granuloma types. Identification of the foreign product might be required for therapeutic or medico-legal reasons. ..
  23. Göhring T, Gallo L, Lüthy H. Effect of water storage, thermocycling, the incorporation and site of placement of glass-fibers on the flexural strength of veneering composite. Dent Mater. 2005;21:761-72 pubmed
    ..There was less deterioration due to water storage and thermocycling with the glass-fiber reinforced veneering composite compared to the non-reinforced materials. ..
  24. Malanga M, Althaus F. The role of poly(ADP-ribose) in the DNA damage signaling network. Biochem Cell Biol. 2005;83:354-64 pubmed
  25. Chia S, Gorna K, Gogolewski S, Alini M. Biodegradable elastomeric polyurethane membranes as chondrocyte carriers for cartilage repair. Tissue Eng. 2006;12:1945-53 pubmed
    ..Further studies will be necessary to better define their role in clinical applications for cartilage repair. ..
  26. Zeisser Labouèbe M, Lange N, Gurny R, Delie F. Hypericin-loaded nanoparticles for the photodynamic treatment of ovarian cancer. Int J Pharm. 2006;326:174-81 pubmed
    ..The influence of NP drug loading on the Hy release from NPs was also investigated. ..
  27. Kissel P, Erni R, Schweizer W, Rossell M, King B, Bauer T, et al. A two-dimensional polymer prepared by organic synthesis. Nat Chem. 2012;4:287-91 pubmed publisher
  28. Gaumet M, Gurny R, Delie F. Fluorescent biodegradable PLGA particles with narrow size distributions: preparation by means of selective centrifugation. Int J Pharm. 2007;342:222-30 pubmed
    ..Such particles may be used as an adequate tool for studying cellular uptake. ..
  29. Nair Pn P, Schug J. Observations on healing of human tooth extraction sockets implanted with bioabsorbable polylactic-polyglycolic acids (PLGA) copolymer root replicas: a clinical, radiographic, and histologic follow-up report of 8 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97:559-69 pubmed
  30. Bustamante M, Roger F, Bochaton Piallat M, Gabbiani G, Martin P, Feraille E. Regulatory volume increase is associated with p38 kinase-dependent actin cytoskeleton remodeling in rat kidney MTAL. Am J Physiol Renal Physiol. 2003;285:F336-47 pubmed
  31. Delley P, Hall M. Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol. 1999;147:163-74 pubmed
    ..Thus, activated RHO1 can mediate both polarized and depolarized cell growth via the same effector, PKC1, suggesting that RHO1 may function as a rheostat rather than as a simple on-off switch. ..
  32. Grad S, Gogolewski S, Alini M, Wimmer M. Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds. Tissue Eng. 2006;12:3171-9 pubmed
    ..It is suggested that the oscillating ball drags the fluid into the joint space, thereby causing biophysical effects similar to those of fluid flow. ..
  33. Guillame Gentil O, Semenov O, Roca A, Groth T, Zahn R, Voros J, et al. Engineering the extracellular environment: Strategies for building 2D and 3D cellular structures. Adv Mater. 2010;22:5443-62 pubmed publisher
    ..Finally, methods to pattern cells in three-dimensions as well as to functionalize the 3D environment with biologic motifs take us one step closer to being able to engineer multicellular tissues and organs...
  34. Gordon O, Vig Slenters T, Brunetto P, Villaruz A, Sturdevant D, Otto M, et al. Silver coordination polymers for prevention of implant infection: thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction. Antimicrob Agents Chemother. 2010;54:4208-18 pubmed publisher
    ..This is the first report investigating the global metabolic effects of silver in the context of a therapeutic application. We anticipate that the compounds presented here open a new treatment field with a high medical impact...
  35. Gervais L, de Rooij N, Delamarche E. Microfluidic chips for point-of-care immunodiagnostics. Adv Mater. 2011;23:H151-76 pubmed publisher
    ..Finally, we discuss the integration of components into accurate and reliable devices. ..
  36. Avaltroni F, Seijo M, Ulrich S, Stoll S, Wilkinson K. Conformational changes and aggregation of alginic acid as determined by fluorescence correlation spectroscopy. Biomacromolecules. 2007;8:106-12 pubmed
    ..From diffusion coefficients and radii of gyration obtained as a function of ionic strength, persistence lengths (total, electrostatic, and intrinsic) were calculated from the Benoit-Doty relationship...
  37. Lecoanet Henchoz S, Plater Zyberk C, Graber P, Gretener D, Aubry J, Conrad D, et al. Mouse CD23 regulates monocyte activation through an interaction with the adhesion molecule CD11b/CD18. Eur J Immunol. 1997;27:2290-4 pubmed
    ..These results demonstrate that similar to findings using human cells, murine CD23 binds to the surface adhesion molecule, CD11b, and these interactions regulate biological activities of murine myeloid cells. ..
  38. Rochat S, Egger J, Chaintreau A. Strategy for the identification of key odorants: application to shrimp aroma. J Chromatogr A. 2009;1216:6424-32 pubmed publisher
    ..In both shrimp products, the most important odorants were trimethylamine, 2-acetyl-1-pyrroline, and 2-ethyl-3,5-dimethyl pyrazine, together with common carbonyl compounds...
  39. G ttler T, Klostermeier D. Dissection of the nucleotide cycle of B. subtilis DNA gyrase and its modulation by DNA. J Mol Biol. 2007;367:1392-404 pubmed publisher
    ..This suggests that each topoisomerase represents a different solution to the complex reaction sequence in DNA supercoiling...
  40. Boissard C, Bourban P, Tami A, Alini M, Eglin D. Nanohydroxyapatite/poly(ester urethane) scaffold for bone tissue engineering. Acta Biomater. 2009;5:3316-27 pubmed publisher
    ..nHA/poly(ester urethane) composite scaffolds have great potential as osteoconductive constructs for bone tissue engineering...
  41. Aguzzi A. Unraveling prion strains with cell biology and organic chemistry. Proc Natl Acad Sci U S A. 2008;105:11-2 pubmed publisher
  42. Kohlmeier S, Mancuso M, Deepthike U, Tecon R, van der Meer J, Harms H, et al. Comparison of naphthalene bioavailability determined by whole-cell biosensing and availability determined by extraction with Tenax. Environ Pollut. 2008;156:803-8 pubmed publisher
    ..A rationale is provided wherein chemical resistance is speculated to be operative. ..
  43. Boger A, Wheeler K, Montali A, Gruskin E. NMP-modified PMMA bone cement with adapted mechanical and hardening properties for the use in cancellous bone augmentation. J Biomed Mater Res B Appl Biomater. 2009;90:760-6 pubmed publisher
  44. Jan A, Gokce O, Luthi Carter R, Lashuel H. The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity. J Biol Chem. 2008;283:28176-89 pubmed publisher
  45. Keller H, Eggli P. Protrusive activity, cytoplasmic compartmentalization, and restriction rings in locomoting blebbing Walker carcinosarcoma cells are related to detachment of cortical actin from the plasma membrane. Cell Motil Cytoskeleton. 1998;41:181-93 pubmed
    ..The findings suggest that the dynamic events at the front of blebbing metazoan cells are similar to those previously found in Amoeba proteus [Grebecki, Protoplasma, 154:98-111, 1990] but different from those found in lamellipodia...
  46. Frey D, Laux T, Xu L, Schneider C, Caroni P. Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity. J Cell Biol. 2000;149:1443-54 pubmed
  47. Hoepfner D, Van den Berg M, Philippsen P, Tabak H, Hettema E. A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae. J Cell Biol. 2001;155:979-90 pubmed
    ..In addition, time-lapse videos showing peroxisome movement in wild-type and vps1Delta cells suggest the existence of various levels of control involved in the partitioning of peroxisomes. ..
  48. Hirsch V, Kinnear C, Moniatte M, Rothen Rutishauser B, Clift M, Fink A. Surface charge of polymer coated SPIONs influences the serum protein adsorption, colloidal stability and subsequent cell interaction in vitro. Nanoscale. 2013;5:3723-32 pubmed publisher
    ..The results of this study strongly indicate therefore that an understanding of the aggregation state of NPs in biological fluids is crucial in regards to their biological interaction(s). ..
  49. Soldo B, Lazarevic V, Karamata D. tagO is involved in the synthesis of all anionic cell-wall polymers in Bacillus subtilis 168. Microbiology. 2002;148:2079-87 pubmed
  50. Eby J, Dane K, O Neil C, Hirosue S, Swartz M, Hubbell J. Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization. Acta Biomater. 2012;8:3210-7 pubmed publisher
    ..These results indicate that PDS-functionalized MCs are efficient antigen delivery vehicles that enhance immune responses compared to immunization with free protein. ..
  51. Bucheli Witschel M, Kötzsch S, Darr S, Widler R, Egli T. A new method to assess the influence of migration from polymeric materials on the biostability of drinking water. Water Res. 2012;46:4246-60 pubmed publisher
    ..Results obtained with the new assay for a number of materials typically used in drinking water and sanitary installations are reported. ..
  52. Stefanini G, Kalesan B, Serruys P, Heg D, Buszman P, Linke A, et al. Long-term clinical outcomes of biodegradable polymer biolimus-eluting stents versus durable polymer sirolimus-eluting stents in patients with coronary artery disease (LEADERS): 4 year follow-up of a randomised non-inferiority trial. Lancet. 2011;378:1940-8 pubmed publisher
    ..Biosensors Europe SA, Switzerland. ..