Experts and Doctors on phosphorylation in Israel


Locale: Israel
Topic: phosphorylation

Top Publications

  1. Gross E, Goldberg D, Levitzki A. Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras. Nature. 1992;360:762-5 pubmed
    ..These results are of general significance because of the highly conserved sequence of Ras-guanyl nucleotide exchange factors from yeasts to mammals. ..
  2. Agami R, Blandino G, Oren M, Shaul Y. Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature. 1999;399:809-13 pubmed
    ..Moreover, p73 is phosphorylated in vivo in response to ionizing radiation. These findings define a pro-apoptotic signalling pathway involving p73 and c-Abl. ..
  3. Monsonego Ornan E, Adar R, Rom E, Yayon A. FGF receptors ubiquitylation: dependence on tyrosine kinase activity and role in downregulation. FEBS Lett. 2002;528:83-9 pubmed
    ..We conclude that phosphorylation is essential for FGFR3 ubiquitylation, but is not sufficient to induce downregulation of its internalization resistant mutants. ..
  4. Buchs A, Chagag P, Weiss M, Kish E, Levinson R, Aharoni D, et al. Normal p21Ras/MAP kinase pathway expression and function in PBMC from patients with polycystic ovary disease. Int J Mol Med. 2004;13:595-9 pubmed
    ..These data indicate that the expression and overall function of the p21Ras/MAP kinase pathway remain intact in non-diabetic patients with PCOD. ..
  5. Kochupurakkal B, Harari D, Di Segni A, Maik Rachline G, Lyass L, Gur G, et al. Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J Biol Chem. 2005;280:8503-12 pubmed
    ..In conclusion, EPG might represent the last EGF-like growth factor and define a category of low affinity ligands, whose bioactivity differs from the more extensively studied high affinity ligands. ..
  6. Kamer I, Sarig R, Zaltsman Y, Niv H, Oberkovitz G, Regev L, et al. Proapoptotic BID is an ATM effector in the DNA-damage response. Cell. 2005;122:593-603 pubmed
    ..These results implicate BID as an ATM effector and raise the possibility that proapoptotic BID may also play a prosurvival role important for S phase arrest. ..
  7. Gelkop S, Gish G, Babichev Y, Pawson T, Isakov N. T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315. J Immunol. 2005;175:8123-32 pubmed
  8. Kalie E, Jaitin D, Abramovich R, Schreiber G. An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities. J Biol Chem. 2007;282:11602-11 pubmed
    ..This work demonstrates the application of detailed biophysical understanding in the process of protein engineering, yielding an interferon variant with highly increased biological potency. ..
  9. Cohen Hillel E, Yron I, Meshel T, Ben Baruch A. Interleukin 8 and cell migration to inflammatory sites: the regulation of focal adhesion kinase under conditions of migratory desensitization. Isr Med Assoc J. 2007;9:579-83 pubmed

More Information

Publications182 found, 100 shown here

  1. Sela U, Brill A, Kalchenko V, Dashevsky O, Hershkoviz R. Allicin inhibits blood vessel growth and downregulates Akt phosphorylation and actin polymerization. Nutr Cancer. 2008;60:412-20 pubmed publisher
  2. Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M, et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep. 2009;10:285-92 pubmed publisher
  3. Pietr M, Kozela E, Levy R, Rimmerman N, Lin Y, Stella N, et al. Differential changes in GPR55 during microglial cell activation. FEBS Lett. 2009;583:2071-6 pubmed publisher
  4. Amsalem S, Bakrhat A, Otani T, Hayashi S, Goldstein B, Abdu U. Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like. Mol Cell Biol. 2013;33:4371-80 pubmed publisher
    ..In summary, our results demonstrate that Spn-F mediates the interaction between Ik2 and Jvl to control Ik2 activity. ..
  5. Sahly I, Bar Nachum S, Suss Toby E, Rom A, Peretz A, Kleiman J, et al. Calcium channel blockers inhibit retinal degeneration in the retinal-degeneration-B mutant of Drosophila. Proc Natl Acad Sci U S A. 1992;89:435-9 pubmed
  6. Marash M, Gerst J. t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast. EMBO J. 2001;20:411-21 pubmed
    ..Thus, modulation of t-SNARE phosphorylation regulates SNARE complex assembly and membrane fusion in vivo. ..
  7. Khalaila I, Manor R, Weil S, Granot Y, Keller R, Sagi A. The eyestalk-androgenic gland-testis endocrine axis in the crayfish Cherax quadricarinatus. Gen Comp Endocrinol. 2002;127:147-56 pubmed
    ..The above findings, together with the evidence for direct inhibition by the sinus gland on the AG, suggest an endocrine axis-like relationship between the sinus gland, the AG, and the male reproductive system in decapod crustaceans...
  8. Potashnik R, Bloch Damti A, Bashan N, Rudich A. IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress. Diabetologia. 2003;46:639-48 pubmed
    ..Oxidative stress induces serine phosphorylation of IRS1 and increases its degradation by a proteasome-independent pathway; yet, these changes do not correlate with the induction of impaired metabolic response to insulin. ..
  9. Shmueli A, Gdalyahu A, Sapoznik S, Sapir T, Tsukada M, Reiner O. Site-specific dephosphorylation of doublecortin (DCX) by protein phosphatase 1 (PP1). Mol Cell Neurosci. 2006;32:15-26 pubmed
  10. Bashan N, Dorfman K, Tarnovscki T, Harman Boehm I, Liberty I, Bluher M, et al. Mitogen-activated protein kinases, inhibitory-kappaB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity. Endocrinology. 2007;148:2955-62 pubmed
    ..Increased expression of stress-activated kinases and IKK and their phosphorylated forms in omental fat occurs in obesity, potentially contributing to differential roles of omental and sc fat in the pathophysiology of obesity. ..
  11. Ravid D, Chuderland D, Landsman L, Lavie Y, Reich R, Liscovitch M. Filamin A is a novel caveolin-1-dependent target in IGF-I-stimulated cancer cell migration. Exp Cell Res. 2008;314:2762-73 pubmed publisher
    ..These data indicate that caveolin-1 specifies filamin A as a novel target for Akt-mediated filamin A Ser-2152 phosphorylation thus mediating the effects of caveolin-1 on IGF-I-induced cancer cell migration. ..
  12. Shay B, Gruenbaum Cohen Y, Tucker A, Taylor A, Rosenfeld E, Haze A, et al. High yield expression of biologically active recombinant full length human tuftelin protein in baculovirus-infected insect cells. Protein Expr Purif. 2009;68:90-8 pubmed publisher
    ..These findings support the hypothesis that tuftelin plays an important role during embryogenesis. ..
  13. Mor I, Carlessi R, Ast T, Feinstein E, Kimchi A. Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase. Oncogene. 2012;31:683-93 pubmed publisher
    ..Moreover, the work documents a unique function of DAPk that is independent of its catalytic activity and a novel mechanism to activate PKM2 by protein-protein interaction. ..
  14. Weinberger A, Kamena F, Kama R, Spang A, Gerst J. Control of Golgi morphology and function by Sed5 t-SNARE phosphorylation. Mol Biol Cell. 2005;16:4918-30 pubmed
    ..Thus, a cycle of Sed5 phosphorylation and dephosphorylation is required for normal t-SNARE function and may choreograph Golgi ordering and dispersal. ..
  15. Motzik A, Amir E, Erlich T, Wang J, Kim B, Han J, et al. Post-translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells. Oncogene. 2017;36:4732-4738 pubmed publisher
    ..Thus, we provided here an example that manipulation of the LysRS-Ap4A-HINT1-MITF signalling pathway in melanoma through post-translational modifications of HINT1 can affect the activity of the melanoma oncogene MITF. ..
  16. Avitzour M, Diskin R, Raboy B, Askari N, Engelberg D, Livnah O. Intrinsically active variants of all human p38 isoforms. FEBS J. 2007;274:963-75 pubmed
    ..These active variants could now become powerful tools for the elucidating the activation mechanism and specific biological roles of each p38 isoform. ..
  17. Madar S, Harel E, Goldstein I, Stein Y, Kogan Sakin I, Kamer I, et al. Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta. PLoS ONE. 2013;8:e61353 pubmed publisher
    ..These data underscore mutant p53 oncogenic properties in the context of the tumor microenvironment and suggest that mutant p53 positive cancer patients might benefit from IFN? treatment. ..
  18. Oyler Yaniv J, Oyler Yaniv A, Shakiba M, Min N, Chen Y, Cheng S, et al. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. 2017;66:635-647.e7 pubmed publisher
    ..This mechanism introduces an additional function for PS in dynamically regulating inflammation across diverse cancer and primary cell types and has potential to usher in new immunotherapies targeting PS and inflammatory pathways. ..
  19. Eisenbach M. Control of bacterial chemotaxis. Mol Microbiol. 1996;20:903-10 pubmed
    ..Additional control sites might be involved in bacterial chemotaxis, e.g. lateral control at the receptor level, control at the motor level, or control by metabolites that link central metabolism with chemotaxis. ..
  20. Dardik R, Loscalzo J, Eskaraev R, Inbal A. Molecular mechanisms underlying the proangiogenic effect of factor XIII. Arterioscler Thromb Vasc Biol. 2005;25:526-32 pubmed
    ..These processes may clarify FXIII role in vascular remodeling and tissue repair. ..
  21. Shiryaev N, Jouroukhin Y, Giladi E, Polyzoidou E, Grigoriadis N, Rosenmann H, et al. NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model. Neurobiol Dis. 2009;34:381-8 pubmed publisher
    ..The current studies show for the first time activity for NAP in a "pure" tauopathy model, positioning it as a promising drug candidate in multiple neurodegenerative tauopathies. ..
  22. Maya R, Balass M, Kim S, Shkedy D, Leal J, Shifman O, et al. ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev. 2001;15:1067-77 pubmed
    ..Our findings imply that activation of p53 by DNA damage is achieved, in part, through attenuation of the p53-inhibitory potential of Mdm2. ..
  23. Biener E, Martin C, Daniel N, Frank S, Centonze V, Herman B, et al. Ovine placental lactogen-induced heterodimerization of ovine growth hormone and prolactin receptors in living cells is demonstrated by fluorescence resonance energy transfer microscopy and leads to prolonged phosphorylation of signal transducer and a. Endocrinology. 2003;144:3532-40 pubmed
  24. Ben Zeev E, Fux L, Amster Choder O, Eisenstein M. Experimental and computational characterization of the dimerization of the PTS-regulation domains of BglG from Escherichia coli. J Mol Biol. 2005;347:693-706 pubmed
    ..This different conduct may be attributed to a single replacement in the sequence of PRD2 in BglG compared to LicT, Ala262 versus Asp261, respectively. ..
  25. Budick Harmelin N, Anavi S, Madar Z, Tirosh O. Fatty acids-stress attenuates gluconeogenesis induction and glucose production in primary hepatocytes. Lipids Health Dis. 2012;11:66 pubmed publisher
    ..The present results demonstrate that free-FAs directly inhibit the induced gluconeogenic response in hepatocytes. Hence, high levels of free-FAs may attenuate hepatic gluconeogenesis, and liver glucose output. ..
  26. Farberov S, Meidan R. Thrombospondin-1 Affects Bovine Luteal Function via Transforming Growth Factor-Beta1-Dependent and Independent Actions. Biol Reprod. 2016;94:25 pubmed publisher
    ..Indeed all these three genes were similarly induced in the regressing CL. Their gene products can promote vascular instability, apoptosis, and matrix remodeling during luteolysis. ..
  27. Shur I, Benayahu D. Characterization and functional analysis of CReMM, a novel chromodomain helicase DNA-binding protein. J Mol Biol. 2005;352:646-55 pubmed
    ..Further delineation of the function of this protein will provide information about its dynamics in transcriptional regulation of mesenchymal cells. ..
  28. Schweitzer R, Shaharabany M, Seger R, Shilo B. Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 1995;9:1518-29 pubmed
    ..In embryos mutant for rho or Star the ventralizing effect of secreted Spitz is epistatic, suggesting that Rho and Star may normally facilitate processing of the Spitz precursor. ..
  29. Levkowitz G, Waterman H, Ettenberg S, Katz M, Tsygankov A, Alroy I, et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell. 1999;4:1029-40 pubmed
    ..Our study identifies Cbl proteins as components of the ubiquitin ligation machinery and implies that they similarly suppress many other signaling pathways. ..
  30. Levkovitch Verbin H, Quigley H, Martin K, Harizman N, Valenta D, Pease M, et al. The transcription factor c-jun is activated in retinal ganglion cells in experimental rat glaucoma. Exp Eye Res. 2005;80:663-70 pubmed
    ..C-jun is activated more gradually in glaucoma then after optic nerve transection. ..
  31. Sines T, Granot Attas S, Weisman Welcher S, Elson A. Association of tyrosine phosphatase epsilon with microtubules inhibits phosphatase activity and is regulated by the epidermal growth factor receptor. Mol Cell Biol. 2007;27:7102-12 pubmed
    ..The data suggest that reversible association with microtubules is a novel, physiologically regulated mechanism for regulation of tyrosine phosphatase activity in cells. ..
  32. Granot I, Bechor E, Barash A, Dekel N. Connexin43 in rat oocytes: developmental modulation of its phosphorylation. Biol Reprod. 2002;66:568-73 pubmed
    ..Our findings demonstrate that rat oocytes express a developmentally regulated Cx43. They further suggest that homotypic gap junctions that consist of Cx43 may be present between rat oocytes and their adjacent cumulus cells. ..
  33. Jona G, Livi L, Gileadi O. Mutations in the RING domain of TFB3, a subunit of yeast transcription factor IIH, reveal a role in cell cycle progression. J Biol Chem. 2002;277:39409-16 pubmed
    ..To conclude, in the present study we bring another demonstration of the multifunctional nature of TFIIH. ..
  34. Hershko T, Chaussepied M, Oren M, Ginsberg D. Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. Cell Death Differ. 2005;12:377-83 pubmed
    ..Overall, these data provide novel functional links between RB/E2F pathway and p53-induced apoptosis. ..
  35. Hemi R, Yochananov Y, Barhod E, Kasher Meron M, Karasik A, Tirosh A, et al. p38 mitogen-activated protein kinase-dependent transactivation of ErbB receptor family: a novel common mechanism for stress-induced IRS-1 serine phosphorylation and insulin resistance. Diabetes. 2011;60:1134-45 pubmed publisher
    ..Hepatic p38MAPK is activated following various stress stimuli. This event is upstream to ErbB receptors transactivation and plays an important role in stress-induced IRS-1 serine phosphorylation and insulin resistance. ..
  36. Boege Y, Malehmir M, Healy M, Bettermann K, Lorentzen A, Vucur M, et al. A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell. 2017;32:342-359.e10 pubmed publisher
    ..It may represent a DNA damage-sensing mechanism in hepatocytes that can act via JNK and subsequent phosphorylation of the histone variant H2AX. ..
  37. Di Capua N, Sperling O, Zoref Shani E. Protein kinase C-epsilon is involved in the adenosine-activated signal transduction pathway conferring protection against ischemia-reperfusion injury in primary rat neuronal cultures. J Neurochem. 2003;84:409-12 pubmed
    ..These results demonstrate that activation of PKC-epsilon is a vital step in the neuronal adenosine-activated STP. ..
  38. Toledano Katchalski H, Tiran Z, Sines T, Shani G, Granot Attas S, den Hertog J, et al. Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon. Mol Cell Biol. 2003;23:5460-71 pubmed
    ..Furthermore, dimerization can be mediated by the D2 domain and does not strictly require the presence of PTP extracellular domains. ..
  39. Eisenberg Lerner A, Kimchi A. DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress. Cell Death Differ. 2007;14:1908-15 pubmed
    ..Taken together, these findings establish a major role for DAPk and its specific interaction with PKD in regulating the JNK signaling network under oxidative stress. ..
  40. Gabriely G, Kama R, Gelin Licht R, Gerst J. Different domains of the UBL-UBA ubiquitin receptor, Ddi1/Vsm1, are involved in its multiple cellular roles. Mol Biol Cell. 2008;19:3625-37 pubmed publisher
    ..g., Ddi1, Ddi1(S341A)) rescue the growth of sec9-4 cells similar to Sso1 overproduction. Thus, Ddi1 participates in multiple cellular processes via its different domains and phosphorylation may regulate exocytic functions. ..
  41. Costa B, Kean M, Ast V, Knight J, Mett A, Levy Z, et al. STK25 protein mediates TrkA and CCM2 protein-dependent death in pediatric tumor cells of neural origin. J Biol Chem. 2012;287:29285-9 pubmed publisher
    ..These findings delineate a death-signaling pathway downstream of neurotrophic receptor tyrosine kinases that may provide targets for therapeutic intervention in pediatric tumors of neural origin. ..
  42. Shani G, Henis Korenblit S, Jona G, Gileadi O, Eisenstein M, Ziv T, et al. Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding. EMBO J. 2001;20:1099-113 pubmed
    ..This mechanism of negative autophosphorylation provides a safety barrier that restrains the killing effects of DRP-1, and a target for efficient activation of the kinase by various apoptotic stimuli. ..
  43. Gurunathan S, Marash M, Weinberger A, Gerst J. t-SNARE phosphorylation regulates endocytosis in yeast. Mol Biol Cell. 2002;13:1594-607 pubmed
    ..These results suggest that endocytosis is also modulated by t-SNARE phosphorylation in vivo. ..
  44. Litvak V, Shaul Y, Shulewitz M, Amarilio R, Carmon S, Lev S. Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain. Curr Biol. 2002;12:1513-8 pubmed
  45. Diamant G, Amir Zilberstein L, Yamaguchi Y, Handa H, Dikstein R. DSIF restricts NF-?B signaling by coordinating elongation with mRNA processing of negative feedback genes. Cell Rep. 2012;2:722-31 pubmed publisher
    ..These findings assign a function for DSIF in cotranscriptional mRNA processing when elongating Pol II is hypophosphorylated and define DSIF as part of the negative feedback regulation of NF-?B. ..
  46. Sapir T, Cahana A, Seger R, Nekhai S, Reiner O. LIS1 is a microtubule-associated phosphoprotein. Eur J Biochem. 1999;265:181-8 pubmed
    ..In vitro, LIS1 was phosphorylated by protein kinase CKII (casein kinase II), but not many other kinases that were tested. We suggest that LIS1 activity may be regulated by phosphorylation. ..
  47. Kraus S, Naor Z, Seger R. Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptor. Arch Med Res. 2001;32:499-509 pubmed
    ..Understanding the signaling mechanisms elicited by GnRHR can shed light on the mechanism of action of GnRH in pituitary and extra-pituitary tissues. ..
  48. Gdalyahu A, Ghosh I, Levy T, Sapir T, Sapoznik S, Fishler Y, et al. DCX, a new mediator of the JNK pathway. EMBO J. 2004;23:823-32 pubmed
  49. Szaingurten Solodkin I, Hadad N, Levy R. Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia. Glia. 2009;57:1727-40 pubmed publisher
  50. Peles E, Lamprecht R, Ben Levy R, Tzahar E, Yarden Y. Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation. J Biol Chem. 1992;267:12266-74 pubmed
    ..Hence, we concluded that phosphatidylinositol 3'-kinase is a physiological substrate of the Neu receptor, but the regulation of this coupling is released upon oncogenic activation. ..
  51. Blat Y, Eisenbach M. Phosphorylation-dependent binding of the chemotaxis signal molecule CheY to its phosphatase, CheZ. Biochemistry. 1994;33:902-6 pubmed
  52. Shaul Y, Gibor G, Plotnikov A, Seger R. Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade. Genes Dev. 2009;23:1779-90 pubmed publisher
    ..These results illustrate that the ERK cascade is divided into two routes: the classic MEK1/2-ERK1/2 and the splice-variant MEK1b-ERK1c, each of which regulates distinct cellular processes and thus extends the cascade specificity. ..
  53. Shefler I, Pasmanik Chor M, Kidron D, Mekori Y, Hershko A. T cell-derived microvesicles induce mast cell production of IL-24: relevance to inflammatory skin diseases. J Allergy Clin Immunol. 2014;133:217-24.e1-3 pubmed publisher
    ..We propose that this MC-derived cytokine might contribute to the pathologic findings in T cell-mediated skin inflammation. ..
  54. Amsterdam A, Tajima K, Frajese V, Seger R. Analysis of signal transduction stimulated by gonadotropins in granulosa cells. Mol Cell Endocrinol. 2003;202:77-80 pubmed
    ..Steroidogenic factor-1 and DAX-1 may be involved in the regulation of the MAPK-dependent attenuation of steroidogenesis, since they exhibit sites that could be potentially phosphorylated by the MAPK cascade. ..
  55. Maik Rachline G, Shaltiel S, Seger R. Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor. Blood. 2005;105:670-8 pubmed
    ..This is a novel role of extracellular phosphorylation that is shown here to completely change the nature of PEDF from a neutrophic to an antiangiogenic factor. ..
  56. Prizant R, Barash I. Negative effects of the amino acids Lys, His, and Thr on S6K1 phosphorylation in mammary epithelial cells. J Cell Biochem. 2008;105:1038-47 pubmed publisher
    ..These findings indicate that positive and negative signaling from AA to the mTOR pathway, combined with modulation of insulin sensitization, mediate the synthesis rates of total and specific milk proteins in mammary epithelial cells. ..
  57. Tarcic G, Boguslavsky S, Wakim J, Kiuchi T, Liu A, Reinitz F, et al. An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. Curr Biol. 2009;19:1788-98 pubmed publisher
    ..These observations highlight the emerging roles of vesicular trafficking in malignant processes. ..
  58. Zargarian S, Shlomovitz I, Erlich Z, Hourizadeh A, Ofir Birin Y, Croker B, et al. Phosphatidylserine externalization, "necroptotic bodies" release, and phagocytosis during necroptosis. PLoS Biol. 2017;15:e2002711 pubmed publisher
    ..The exposure of PS to the outer membrane and to extracellular vesicles is therefore a feature of necroptotic cell death and may serve to provide an immunologically-silent window by generating specific "find me" and "eat me" signals. ..
  59. Shelly M, Pinkas Kramarski R, Guarino B, Waterman H, Wang L, Lyass L, et al. Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes. J Biol Chem. 1998;273:10496-505 pubmed
    ..This remarkable discrepancy between binding affinity and bioactivity is permitted by a mechanism that prevents receptor down-regulation, and results in a weak, but prolonged, state of receptor activation. ..
  60. Agami R, Shaul Y. The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes. Oncogene. 1998;16:1779-88 pubmed
    ..Collectively, we describe a novel mechanism of c-Abl recruitment to a defined DNA-cis element with its concomitant kinase activation. We propose that this mechanism may act to regulate cell-cycle control genes. ..
  61. Hazan Halevy I, Seger R, Levy R. The requirement of both extracellular regulated kinase and p38 mitogen-activated protein kinase for stimulation of cytosolic phospholipase A(2) activity by either FcgammaRIIA or FcgammaRIIIB in human neutrophils. A possible role for Pyk2 but not for . J Biol Chem. 2000;275:12416-23 pubmed
    ..Thus, although ERK activation is significantly shorter than that of p38 MAP kinase, it is equally required for activation and maintenance of cPLA(2) activity by occupancy of a single receptor, FcgammaRIIA or FcgammaRIIIB. ..
  62. Ziv C, Kra Oz G, Gorovits R, März S, Seiler S, Yarden O. Cell elongation and branching are regulated by differential phosphorylation states of the nuclear Dbf2-related kinase COT1 in Neurospora crassa. Mol Microbiol. 2009;74:974-89 pubmed publisher
    ..We conclude that COT1 regulates elongation and branching in an independent manner, which is determined by its phosphorylation state...
  63. Beery R, Haimsohn M, Wertheim N, Hemi R, Nir U, Karasik A, et al. Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and evans blue. Endocrinology. 2001;142:3098-107 pubmed
    ..Taken together, these results suggest that the survival/proliferation-promoting effects of ATA and EB in MCF-7 cells are transduced via the IGF-IR signaling pathway...
  64. Genis I, Gordon I, Sehayek E, Michaelson D. Phosphorylation of tau in apolipoprotein E-deficient mice. Neurosci Lett. 1995;199:5-8 pubmed
    ..These results suggest that tau of apoE-deficient mice is hyperphosphorylated. ..
  65. Tzahar E, Waterman H, Chen X, Levkowitz G, Karunagaran D, Lavi S, et al. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol. 1996;16:5276-87 pubmed
    ..The observed superior ability of ErbB-2 to form heterodimers, in conjunction with its uniquely high basal tyrosine kinase activity, may explain why ErbB-2 overexpression is associated with poor prognosis. ..
  66. Seger D, Gechtman Z, Shaltiel S. Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading. J Biol Chem. 1998;273:24805-13 pubmed
  67. Barak R, Prasad K, Shainskaya A, Wolfe A, Eisenbach M. Acetylation of the chemotaxis response regulator CheY by acetyl-CoA synthetase purified from Escherichia coli. J Mol Biol. 2004;342:383-401 pubmed
    ..Thus, CheY is similar to many eukaryotic proteins involved in signaling, which undergo both phosphorylation and multiple acetylation, and in which the acetylation sites are restricted to a particular region. ..
  68. Ben David H, Venkata Aruna B, Sela M, Mozes E. A dual altered peptide ligand inhibits myasthenia gravis associated responses by inducing phosphorylated extracellular-regulated kinase 1,2 that upregulates CD4+CD25+Foxp3+ cells. Scand J Immunol. 2007;65:567-76 pubmed
  69. Peles E, Levy R, Or E, Ullrich A, Yarden Y. Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma. EMBO J. 1991;10:2077-86 pubmed
    ..Based on the presented results we suggest that the mechanism of cellular transformation by the neu/HER2 receptor involves tyrosine phosphorylation and activation of PLC gamma. ..
  70. Reizel Y, Elbaz J, Dekel N. Sustained activity of the EGF receptor is an absolute requisite for LH-induced oocyte maturation and cumulus expansion. Mol Endocrinol. 2010;24:402-11 pubmed publisher
    ..These new data shed light on the unique characteristics of EGFR-ERK1/2 activity in the ovarian follicle and emphasize the fact that the ovulatory process involves a nonclassical activation of this pathway. ..
  71. Raveh A, Cooper A, Guy David L, Reuveny E. Nonenzymatic rapid control of GIRK channel function by a G protein-coupled receptor kinase. Cell. 2010;143:750-60 pubmed publisher
    ..The findings thus reveal a stimulus-specific, phosphorylation-independent mechanism for rapidly downregulating GPCR activity at the effector level. ..
  72. Pinkas Kramarski R, Soussan L, Waterman H, Levkowitz G, Alroy I, Klapper L, et al. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J. 1996;15:2452-67 pubmed
    ..It is conceivable that combinatorial receptor interactions diversify signal transduction and confer double regulation, in cis and in trans, of the superior mitogenic activity of the kinase-defective ErbB-3. ..
  73. Granot Attas S, Elson A. Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells. Exp Cell Res. 2004;294:236-43 pubmed
    ..We conclude that RPTP activates Src, Yes, and Fyn, but that these related kinases play distinct roles in Neu-induced mammary tumor cells. ..
  74. Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, et al. Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. Mol Cell. 2004;14:319-30 pubmed
    ..These results demonstrate a mechanism for coordinating mitotic and cytokinetic events with Golgi rearrangement during cell division. ..
  75. Luxenburg C, Addadi L, Geiger B. The molecular dynamics of osteoclast adhesions. Eur J Cell Biol. 2006;85:203-11 pubmed
    ..Studying the nature of the proteins that undergo de-phosphorylation is critical for the understanding of the mechanisms regulating the processes described above. ..
  76. Mosesson Y, Chetrit D, Schley L, Berghoff J, Ziv T, Carvalho S, et al. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Dev Cell. 2009;16:687-98 pubmed publisher
    ..These results establish an ubiquitin-based endosomal switch of receptor sorting, functionally equivalent to the mechanism inactivating Hrs via monoubiquitinylation. ..
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