Experts and Doctors on phosphoproteins in Germany

Summary

Locale: Germany
Topic: phosphoproteins

Top Publications

  1. Hecht A, Litterst C, Huber O, Kemler R. Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro. J Biol Chem. 1999;274:18017-25 pubmed
  2. Lehr S, Kotzka J, Herkner A, Sikmann A, Meyer H, Krone W, et al. Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro. Biochemistry. 2000;39:10898-907 pubmed
    ..et al. (1999) Biochemistry 38, 151-159]. These differences in the phosphorylation pattern of hGab-1 may contribute to signaling specificity by different tyrosine kinase receptors engaging distinct SH2 signaling molecules. ..
  3. Brüstle B, Kreissl S, Mykles D, Rathmayer W. The neuropeptide proctolin induces phosphorylation of a 30 kDa protein associated with the thin filament in crustacean muscle. J Exp Biol. 2001;204:2627-35 pubmed
    ..After separation of myofibrillar filaments, a 30 kDa protein was found only in the thin filament fraction. This protein is phosphorylated and detected by an antiserum against crustacean troponin I. ..
  4. Kübler D. Ecto-protein kinase substrate p120 revealed as the cell-surface-expressed nucleolar phosphoprotein Nopp140: a candidate protein for extracellular Ca2+-sensing. Biochem J. 2001;360:579-87 pubmed
    ..Our results indicate that, in addition to nucleolin, a further nucleolar protein, which was considered initially to be strictly intracellular, is identified as a cell-surface phosphoprotein. ..
  5. von Knethen A, Brüne B. Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst. J Immunol. 2002;169:2619-26 pubmed
    ..We conclude that NO participates in controlling the pro- vs anti-inflammatory phenotype of macrophages by modulating PPARgamma. ..
  6. Schreyer S, Ledwig D, Rakatzi I, Kloting I, Eckel J. Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor. Endocrinology. 2003;144:1211-8 pubmed
    ..Our data suggest that IRS-4 does not function as a substrate of the insulin and the IGF-I receptor in primary muscle cells but may be involved in nonreceptor tyrosine kinase signaling. ..
  7. Mayerle J, Friess H, Buchler M, Schnekenburger J, Weiss F, Zimmer K, et al. Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer. Gastroenterology. 2003;124:949-60 pubmed
    ..Both p120(ctn)-defective tumor cell contacts and p120(ctn)-mediated growth signals appear to contribute to the aggressive spread of pancreatic cancer. ..
  8. Koltzscher M, Neumann C, König S, Gerke V. Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P. Mol Biol Cell. 2003;14:2372-84 pubmed
    ..This identifies S100P as a novel activator of ezrin and indicates that activation of ezrin's cross-linking function can occur directly in response to Ca2+ transients. ..
  9. Wu Y, Chen Z, Ullrich A. EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. Biol Chem. 2003;384:1215-26 pubmed
    ..Our findings support a broader role of FRS2 in EGFR-controlled signaling pathways in A-431 cells and provide insight into a molecular mechanism for ligand-stimulated feedback regulation with FRS2 as a central regulatory switch point. ..

More Information

Publications274 found, 100 shown here

  1. Prothmann C, Armstrong N, Roth S, Rupp R. Vertebrate Rel proteins exhibit Dorsal-like activities in early Drosophila embryogenesis. Dev Dyn. 2006;235:949-57 pubmed
    ..Our results suggest the interaction between Rel proteins and their cytoplasmic inhibitors as an important interface of evolutionary adaptation. ..
  2. Schreiner D, Müller K, Hofer H. The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins. FEBS Lett. 2006;580:5295-300 pubmed
    ..As Homer proteins and Fat1 have been both linked to psychic disorders, their interaction may be of patho-physiological importance. ..
  3. Pan C, Gnad F, Olsen J, Mann M. Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics. 2008;8:4534-46 pubmed publisher
    ..Finally, we devised a triple labeling strategy comprising control cells, stimulated cells, and phosphatase treated cells to derive an upper bound on phosphorylation occupancy. ..
  4. Schmidt M. LEEways: tales of EPEC, ATEC and EHEC. Cell Microbiol. 2010;12:1544-52 pubmed publisher
    ..coli during infection. ..
  5. Franz Wachtel M, Eisler S, Krug K, Wahl S, Carpy A, Nordheim A, et al. Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics. 2012;11:160-70 pubmed publisher
    ..This study presents the first global detection of PKD1-dependent phosphorylation events and provides a wealth of information for functional follow-up of PKD1 activity upon disruption of the Golgi network in human cells...
  6. Oerlecke I, Bauer E, Dittmer A, Leyh B, Dittmer J. Cyclic AMP enhances TGF? responses of breast cancer cells by upregulating TGF? receptor I expression. PLoS ONE. 2013;8:e54261 pubmed publisher
    ..g. induced by mesenchymal stem cells, involve the upregulation of T?RI expression on the transcriptional level, likely due to changes in histone acetylation. As a consequence, cancer cell functions such as proliferation are affected. ..
  7. Dechert U, Weber P, Konig B, Ortwein C, Nilson I, Linxweiler W, et al. A protein kinase isolated from porcine brain microvessels is similar to a class of heat-shock proteins. Eur J Biochem. 1994;225:805-9 pubmed
    ..The results indicate that at least some members of the HSP 90 subfamily undergo autophosphorylation and show protein kinase activity by phosphorylating substrate proteins in vitro. ..
  8. Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B. Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3. Cytogenet Cell Genet. 1996;75:132-5 pubmed
    ..The cDNA is highly conserved between rat and human. Human AP17, gene symbol CLAPS2 (clathrin-associated/assembly/adaptor protein, small 3, 17 kDa), was assigned to chromosome region 19q13.2-->q13.3. ..
  9. Marie Cardine A, Verhagen A, Eckerskorn C, Schraven B. SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. FEBS Lett. 1998;435:55-60 pubmed
    ..Finally, we demonstrate that, as previously shown for SKAP55, SKAP-HOM interacts with the recently identified polypeptide SLAP-130. ..
  10. Schafer H, Diebel J, Arlt A, Trauzold A, Schmidt W. The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB. FEBS Lett. 1998;436:139-43 pubmed
    ..These data imply that human p22/PRG1 is a target gene for p53 and NFkappaB involved in growth regulation and stress response. ..
  11. Lehr S, Kotzka J, Herkner A, Klein E, Siethoff C, Knebel B, et al. Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro. Biochemistry. 1999;38:151-9 pubmed
    ..These results demonstrate that hGab-1 is a high-affinity substrate for the EGFR and the major tyrosine phosphorylation site Y657 in the C terminus is a specific binding site for the tyrosine phosphatase Syp. ..
  12. You L, Ebner S, Kruse F. Glial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2001;42:2496-504 pubmed
    ..FAK seems to be an upstream regulator of the MAPK cascade for GDNF signal transduction. As an inducer of FAK-dependent corneal epithelial migration, GDNF may play an important role in corneal regeneration and wound healing. ..
  13. Walther T, Fornerod M, Pickersgill H, Goldberg M, Allen T, Mattaj I. The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J. 2001;20:5703-14 pubmed
    ..Our results therefore reveal functions for Nup153 in NPC assembly, in anchoring NPCs within the NE and in mediating specific nuclear import events. ..
  14. Roth U, Jungermann K, Kietzmann T. Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes. Biochem J. 2002;365:223-8 pubmed
    ..Venous pO2 enhanced HNF-4 levels and HNF-4 binding to the GK-HNF-4 element. Thus, HNF-4alpha could play the role of a regulator for zonated GK expression. ..
  15. Jumaa H, Bossaller L, Portugal K, Storch B, Lotz M, Flemming A, et al. Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia. Nature. 2003;423:452-6 pubmed
    ..Thus, the somatic loss of SLP-65 and the accompanying block in pre-B-cell differentiation might be one of the primary causes of childhood pre-B ALL. ..
  16. Klamp T, Boehm U, Schenk D, Pfeffer K, Howard J. A giant GTPase, very large inducible GTPase-1, is inducible by IFNs. J Immunol. 2003;171:1255-65 pubmed
    ..In addition, we provide evidence that VLIG-1 is polymorphic in mice of different genetic backgrounds and is a member of a small gene family on mouse chromosome 7 with a conserved homologue located on human chromosome 11. ..
  17. Habedanck R, Stierhof Y, Wilkinson C, Nigg E. The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol. 2005;7:1140-6 pubmed
    ..These findings provide an attractive explanation for the crucial function of Plk4 in cell proliferation and have implications for the role of Polo kinases in tumorigenesis. ..
  18. Klenk C, Humrich J, Quitterer U, Lohse M. SUMO-1 controls the protein stability and the biological function of phosducin. J Biol Chem. 2006;281:8357-64 pubmed
    ..Together, these findings show that phosducin is a previously unrecognized target of SUMO modification and that SUMOylation controls phosducin stability in cells as well as its functional properties. ..
  19. Arnhold S, Heiduschka P, Klein H, Absenger Y, Basnaoglu S, Kreppel F, et al. Adenovirally transduced bone marrow stromal cells differentiate into pigment epithelial cells and induce rescue effects in RCS rats. Invest Ophthalmol Vis Sci. 2006;47:4121-9 pubmed
    ..Taken together, these results raise the possibility that MSCs have the potency to replace diseased RPE cells and deliver therapeutic proteins into the subretinal space to protect photoreceptor cells from degeneration. ..
  20. Robenek H, Buers I, Hofnagel O, Lorkowski S, Severs N. GFP-tagged proteins visualized by freeze-fracture immuno-electron microscopy: a new tool in cellular and molecular medicine. J Cell Mol Med. 2009;13:1381-90 pubmed publisher
    ..The application of this approach is illustrated by new findings on PAT-family proteins tagged with GFP transfected into fibroblasts from patients with Niemann-Pick type C disease. ..
  21. Reim K, Regus Leidig H, Ammermüller J, El Kordi A, Radyushkin K, Ehrenreich H, et al. Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4. J Cell Sci. 2009;122:1352-61 pubmed publisher
  22. Paine A, Oelke M, Tischer S, Heuft H, Blasczyk R, Eiz Vesper B. Soluble recombinant CMVpp65 spanning multiple HLA alleles for reconstitution of antiviral CD4+ and CD8+ T-cell responses after allogeneic stem cell transplantation. J Immunother. 2010;33:60-72 pubmed publisher
    ..The production of recombinant sCMVpp65 can easily be adapted to good manufacturing practice conditions and can be used to generate large numbers of immunogenic pathogen-derived proteins for therapeutic applications. ..
  23. Estrada A, Syrovets T, Pitterle K, Lunov O, Büchele B, Schimana Pfeifer J, et al. Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells. Mol Pharmacol. 2010;77:378-87 pubmed publisher
    ..Thus, tirucallic acid derivatives represent a new class of Akt inhibitors with antitumor properties...
  24. Wehner P, Shnitsar I, Urlaub H, Borchers A. RACK1 is a novel interaction partner of PTK7 that is required for neural tube closure. Development. 2011;138:1321-7 pubmed publisher
    ..These data place RACK1 in a novel signaling cascade that translocates DSH to the plasma membrane and regulates vertebrate neural tube closure. ..
  25. Tischer S, Basila M, Maecker Kolhoff B, Immenschuh S, Oelke M, Blasczyk R, et al. Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies. J Transl Med. 2011;9:175 pubmed publisher
    ..HSP70/peptide complexes may be particularly useful to generate stronger T-cell responses in cases of low precursor frequencies and may help to improve the efficiency of antigen-specific T-cell therapy for minor antigens. ..
  26. Gentil M, Hoffmann B, Spang A, Failing K, Goericke Pesch S. Restart of steroidogenesis in dogs during recrudescence of testicular function following downregulation with a GnRH-agonist implant. Cell Tissue Res. 2012;350:513-23 pubmed publisher
    ..05). Thus, downregulation affects the whole cascade of steroidogenesis, whereas withdrawal of inhibition results in a rapid restart, in part indicating a rebound phenomenon. ..
  27. Rad M, Phan H, Kirchrath L, Tan P, Kirchhausen T, Hollenberg C, et al. Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. J Cell Sci. 1995;108 ( Pt 4):1605-15 pubmed
    ..These Golgi-specific effects of apl2 delta in chc1-ts cells provide evidence that Apl2p is a component of an AP complex that interacts with clathrin at the Golgi apparatus. ..
  28. Pietzsch A, Büchler C, Schmitz G. Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene. Biochem Biophys Res Commun. 1998;245:651-7 pubmed
    ..The Dif-2 gene was mapped to chromosome 6p21.3 using in situ hybridization technique. ..
  29. Bauer A, Lickert H, Kemler R, Stappert J. Modification of the E-cadherin-catenin complex in mitotic Madin-Darby canine kidney epithelial cells. J Biol Chem. 1998;273:28314-21 pubmed
    ..Hence, the cadherin/catenin complex is a target for different posttranslational modifications during mitosis, which may also have a profound impact on cadherin-mediated cell-cell adhesion. ..
  30. Harbeck B, Huttelmaier S, Schluter K, Jockusch B, Illenberger S. Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. J Biol Chem. 2000;275:30817-25 pubmed
    ..When overexpressing VASP mutants in eukaryotic cells, they all showed targeting to focal contacts and stress fibers. Our results imply that VASP phosphorylation may act as an immediate negative regulator of actin dynamics. ..
  31. Keicher C, Gambaryan S, Schulze E, Marcus K, Meyer H, Butt E. Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. Biochem Biophys Res Commun. 2004;324:308-16 pubmed
    ..Immunoblotting of LASP-1 in various mouse and human tissues detected a similar prominent expression in non-muscle tissue. Altogether, our data suggest so far no functional differences between human and mouse LASP-1. ..
  32. Brzózka K, Finke S, Conzelmann K. Identification of the rabies virus alpha/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3. J Virol. 2005;79:7673-81 pubmed
    ..Thus, RV P is necessary and sufficient to prevent a critical IFN response in virus-infected cells by targeting activation of IRF-3 by an upstream kinase. ..
  33. Rosenkranz K, Birschmann I, Grunau S, Girzalsky W, Kunau W, Erdmann R. Functional association of the AAA complex and the peroxisomal importomer. FEBS J. 2006;273:3804-15 pubmed
  34. Venkatesan J, Natarajan S, Schwarz K, Mayer S, Alpadi K, Magupalli V, et al. Nicotinamide adenine dinucleotide-dependent binding of the neuronal Ca2+ sensor protein GCAP2 to photoreceptor synaptic ribbons. J Neurosci. 2010;30:6559-76 pubmed publisher
    ..Therefore, GCAP2 is a prime candidate for mediating Ca2+-dependent dynamic changes of synaptic ribbons in photoreceptor synapses. ..
  35. Santamaria A, Wang B, Elowe S, Malik R, Zhang F, Bauer M, et al. The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics. 2011;10:M110.004457 pubmed publisher
  36. Barkhudarova F, Dähnrich C, Rosemann A, Schneider U, Stocker W, Burmester G, et al. Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus. Arthritis Res Ther. 2011;13:R20 pubmed publisher
    ..High titers of aRibPR0 can be associated with lymphocytopenia, and high titers of aRibPR1 can be associated with elevated GGT levels. So far, there is no evidence for a prognostic value of aRibPs for damage. ..
  37. Gensler M, Buschbeck M, Ullrich A. Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1. J Biol Chem. 2004;279:12110-6 pubmed
  38. Goddemeier M, Rensing S, Feix G. Characterization of a maize ribosomal P2 protein cDNA and phylogenetic analysis of the P1/P2 family of ribosomal proteins. Plant Mol Biol. 1996;30:655-8 pubmed
    ..The integration of these data into a phylogenetic tree shows that the P proteins separated into the subspecies P1 and P2 before the eukaryotic kingdoms including plants developed from their ancestor. ..
  39. Burwinkel B, Miglierini G, Jenne D, Gilbert D, Copeland N, Jenkins N, et al. Structure of the human paralemmin gene (PALM), mapping to human chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding mutations in grizzled, mocha, jittery, and hesitant mice. Genomics. 1998;49:462-6 pubmed
    ..Finally, mutation analysis using RNA from mice homozygous for the mutant genes grizzled (gr), mocha (mh), mocha 2J (mh2J), jittery (ji) and hesitant (ji(hes)), which map to this area, excluded mutations in their Palm coding sequences. ..
  40. Krause M, Sechi A, Konradt M, Monner D, Gertler F, Wehland J. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J Cell Biol. 2000;149:181-94 pubmed
  41. Streetz K, Fregien B, Plümpe J, Korber K, Kubicka S, Sass G, et al. Dissection of the intracellular pathways in hepatocytes suggests a role for Jun kinase and IFN regulatory factor-1 in Con A-induced liver failure. J Immunol. 2001;167:514-23 pubmed
    ..Therefore, our experiments indicate that 11418690 ..
  42. Ciarmatori S, Scott P, Sutcliffe J, McLees A, Alzuherri H, Dannenberg J, et al. Overlapping functions of the pRb family in the regulation of rRNA synthesis. Mol Cell Biol. 2001;21:5806-14 pubmed
    ..This reflects an ability of p130 to bind and inactivate the upstream binding factor, UBF. The data imply that rRNA synthesis in living cells is subject to redundant control by endogenous pRb and p130. ..
  43. Buch T, Uthoff Hachenberg C, Waisman A. Protection from autoimmune brain inflammation in mice lacking IFN-regulatory factor-1 is associated with Th2-type cytokines. Int Immunol. 2003;15:855-9 pubmed
    ..These results demonstrate that absence of IRF-1 in myelin-specific T cells results in protection from severe EAE and is associated with a skewing of the T cell response towards T(h)2. ..
  44. Li Z, Laugwitz K, Pinkernell K, Pragst I, Baumgartner C, Hoffmann E, et al. Effects of two Gbetagamma-binding proteins--N-terminally truncated phosducin and beta-adrenergic receptor kinase C terminus (betaARKct)--in heart failure. Gene Ther. 2003;10:1354-61 pubmed
  45. Roth S. The origin of dorsoventral polarity in Drosophila. Philos Trans R Soc Lond B Biol Sci. 2003;358:1317-29; discussion 1329 pubmed
    ..This leads to a nuclear concentration gradient of Dorsal that specifies the cell types along the DV axis of the embryo. ..
  46. Büther K, Plaas C, Barnekow A, Kremerskothen J. KIBRA is a novel substrate for protein kinase Czeta. Biochem Biophys Res Commun. 2004;317:703-7 pubmed
    ..Our studies presented here revealed that KIBRA is a novel substrate for PKCzeta and suggest that PKCzeta phosphorylation may regulate the cellular function of KIBRA. ..
  47. Chavakis T, Keiper T, Matz Westphal R, Hersemeyer K, Sachs U, Nawroth P, et al. The junctional adhesion molecule-C promotes neutrophil transendothelial migration in vitro and in vivo. J Biol Chem. 2004;279:55602-8 pubmed
    ..Thus, JAM-C participates in neutrophil transmigration and thereby provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies. ..
  48. Steuer H, Jaworski A, Elger B, Kaussmann M, Keldenich J, Schneider H, et al. Functional characterization and comparison of the outer blood-retina barrier and the blood-brain barrier. Invest Ophthalmol Vis Sci. 2005;46:1047-53 pubmed
  49. Platta H, Grunau S, Rosenkranz K, Girzalsky W, Erdmann R. Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Nat Cell Biol. 2005;7:817-22 pubmed
    ..Here we demonstrate that the AAA peroxins mediate the ATP-dependent dislocation of the peroxisomal targeting signal-1 (PTS1) receptor from the peroxisomal membrane to the cytosol. ..
  50. Begonja A, Teichmann L, Geiger J, Gambaryan S, Walter U. Platelet regulation by NO/cGMP signaling and NAD(P)H oxidase-generated ROS. Blood Cells Mol Dis. 2006;36:166-70 pubmed
  51. Spadaccini R, Reidt U, Dybkov O, Will C, Frank R, Stier G, et al. Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing. RNA. 2006;12:410-25 pubmed
    ..Our data suggest that p14 lacks inherent specificity for recognizing the branch point, but that some specificity may be achieved by scaffolding interactions involving other components of SF3b. ..
  52. Schmidt T, Kleylein Sohn J, Westendorf J, Le Clech M, Lavoie S, Stierhof Y, et al. Control of centriole length by CPAP and CP110. Curr Biol. 2009;19:1005-11 pubmed publisher
    ..We thus propose that CPAP and CP110 play antagonistic roles in determining the extent of tubulin addition during centriole elongation, thereby controlling the length of newly formed centrioles...
  53. Fröhlich F, Moreira K, Aguilar P, Hubner N, Mann M, Walter P, et al. A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol. 2009;185:1227-42 pubmed publisher
    ..Furthermore, Nce102 inhibits Pkh kinase signaling and is required for plasma membrane organization. Therefore, Nce102 might act as a sensor of sphingolipids that regulates plasma membrane function. ..
  54. Schuhmann K, Pfaller C, Conzelmann K. The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity. J Virol. 2011;85:3162-71 pubmed publisher
    ..Thus, MV V appears to prevent NF-?B-dependent gene expression by retaining p65 in the cytoplasm. These findings reveal NF-?B as a key target of MV and stress the importance of the V protein as the major viral immune-modulatory factor...
  55. Maercker C, Kortwig H, Nikiforov M, Allis C, Lipps H. A nuclear protein involved in apoptotic-like DNA degradation in Stylonychia: implications for similar mechanisms in differentiating and starved cells. Mol Biol Cell. 1999;10:3003-14 pubmed
    ..In all of these nuclei, apoptotic-like DNA breakdown was detected. These data suggest that Spdd1p is a general factor involved in programmed DNA degradation in Stylonychia...
  56. Pepperl S, Munster J, Mach M, Harris J, Plachter B. Dense bodies of human cytomegalovirus induce both humoral and cellular immune responses in the absence of viral gene expression. J Virol. 2000;74:6132-46 pubmed
    ..Finally, such particles could be engineered for efficient delivery of antigens from other pathogens to the immune system. ..
  57. Fischer S, Wobben M, Kleinstück J, Renz D, Schaper W. Effect of astroglial cells on hypoxia-induced permeability in PBMEC cells. Am J Physiol Cell Physiol. 2000;279:C935-44 pubmed
    ..Results suggest that astrocytes protect the BBB from hypoxia-induced paracellular permeability changes by decreasing hypoxia-induced VEGF expression in microvascular endothelial cells...
  58. Helmbrecht K, Kispert A, von Wasielewski R, Brabant G. Identification of a Wnt/beta-catenin signaling pathway in human thyroid cells. Endocrinology. 2001;142:5261-6 pubmed
    ..In summary, our data indicate that elements of the Wnt signaling pathway are expressed in thyroid cells and that this pathway is functionally active. ..
  59. Wick W, Platten M, Weller M. Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta. J Neurooncol. 2001;53:177-85 pubmed
    ..By virtue of its promotion of glioma invasion and its growth regulatory and immunomodulatory properties. TGF-beta continues to be one of the most promising targets for the experimental therapy of human malignant glioma. ..
  60. Garvalov B, Higgins T, Sutherland J, Zettl M, Scaplehorn N, Kocher T, et al. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J Cell Biol. 2003;161:33-9 pubmed
    ..However, using RNAi ablation, we demonstrate that zyxin is required to recruit Tes, as well as Mena and VASP, but not vinculin or paxillin, to focal adhesions. ..
  61. Boehmer C, Embark H, Bauer A, Palmada M, Yun C, Weinman E, et al. Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B. Biochem Biophys Res Commun. 2004;313:998-1003 pubmed
    ..The action of the kinases and NHERF-2 may link urinary citrate excretion to proximal tubular H(+) secretion. ..
  62. Fricker R, Hesse C, Weiss J, Tayrouz Y, Hoffmann M, Unnebrink K, et al. Endothelial venodilator response in carriers of genetic polymorphisms involved in NO synthesis and degradation. Br J Clin Pharmacol. 2004;58:169-77 pubmed
    ..2 +/- 6.0), respectively. This study suggests that the studied polymorphisms of NOSIII and CYBA do not significantly modulate endothelium-dependent venodilation in individuals without vascular risk factors. ..
  63. Klupp B, Granzow H, Klopfleisch R, Fuchs W, Kopp M, Lenk M, et al. Functional analysis of the pseudorabies virus UL51 protein. J Virol. 2005;79:3831-40 pubmed publisher
    ..In conclusion, both conserved tegument proteins, either singly or in combination, are involved in virion morphogenesis in the cytoplasm but are not essential for viral replication in vitro and in vivo...
  64. Picard D. Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90. Exp Cell Res. 2006;312:198-204 pubmed
    ..In contrast, when wild-type p23 is able to bind Hsp90, a more complex FRAP behavior is observed, suggesting that it is quantitatively bound in Hsp90 complexes undergoing a multitude of other interactions. ..
  65. Bausen M, Fuhrmann J, Betz H, O Sullivan G. The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members. Mol Cell Neurosci. 2006;31:376-86 pubmed
    ..Our data suggest that Mena binding to F-actin allows for gephyrin recruitment to the leading edge of uncapped actin filaments. ..
  66. van der Ven P, Ehler E, Vakeel P, Eulitz S, Schenk J, Milting H, et al. Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP. Exp Cell Res. 2006;312:2154-67 pubmed
  67. Dazert S, Schick B, Hartensuer R, Volkenstein S, Aletsee C, Hansen S, et al. Hearing development and spiral ganglion neurite growth in VASP deficient mice. Brain Res. 2007;1178:73-82 pubmed
    ..Temporary VASP deficits in the neonatal inner ear may be compensated by related proteins like MENA leading to a delayed but complete development of hearing function in VASP-/- animals. ..
  68. Hennenberg M, Trebicka J, Fischer H, Heller J, Sauerbruch T. Hepatic VASP upregulation in rats with secondary biliary cirrhosis by expression in the peribiliary vascular plexus. Microvasc Res. 2009;78:235-40 pubmed publisher
    ..In patients with cirrhosis, hepatic VASP expression was upregulated compared to non-cirrhotic patients. VASP may play a role for vascular morphogenesis in the expanding PBP of BDL rats. ..
  69. Pan C, Olsen J, Daub H, Mann M. Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics. 2009;8:2796-808 pubmed publisher
    ..Our assay is streamlined and generic and could become a useful tool in kinase drug development. ..
  70. Rieder M, Brzózka K, Pfaller C, Cox J, Stitz L, Conzelmann K. Genetic dissection of interferon-antagonistic functions of rabies virus phosphoprotein: inhibition of interferon regulatory factor 3 activation is important for pathogenicity. J Virol. 2011;85:842-52 pubmed publisher
    ..Neurovirulence of IFN-resistant RV thus correlates with the capacity of the virus to prevent activation of IRF3 and IRF7. ..
  71. Schimming T, Grabellus F, Roner M, Pechlivanis S, Sucker A, Bielefeld N, et al. pHH3 immunostaining improves interobserver agreement of mitotic index in thin melanomas. Am J Dermatopathol. 2012;34:266-9 pubmed publisher
    ..Further studies are needed to find out if higher sensitivity in the detection of mitosis by pHH3 immunostaining has additional prognostic relevance. ..
  72. Kobsar A, Koessler J, Kehrer L, Gambaryan S, Walter U. The thrombin inhibitors hirudin and Refludan(®) activate the soluble guanylyl cyclase and the cGMP pathway in washed human platelets. Thromb Haemost. 2012;107:521-9 pubmed publisher
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