Experts and Doctors on phospholipase d in United Kingdom


Locale: United Kingdom
Topic: phospholipase d

Top Publications

  1. Ponting C, Kerr I. A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues. Protein Sci. 1996;5:914-22 pubmed
    ..It is suggested that, for each of these enzymes, conserved histidine, lysine, aspartic acid, and/or asparagine residues may be involved in a two-step ping pong mechanism involving an enzyme-substrate intermediate. ..
  2. Ben Smith A, Dove S, Martin A, Wakelam M, Savage C. Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation. Blood. 2001;98:1448-55 pubmed
    ..These results demonstrate that though ligation of FcgammaRIIa and FcgammaRIIIb may be necessary, it is likely that ANCAs require other membrane cofactors for neutrophil activation. ..
  3. Alderton F, Darroch P, Sambi B, McKie A, Ahmed I, Pyne N, et al. G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. J Biol Chem. 2001;276:13452-60 pubmed
    ..Therefore, these findings show that the lipid phosphate phosphatases 1, 1a, and 2 may function to perturb G-protein-coupled receptor signaling per se rather than limiting bioavailability of lipid agonists at their respective receptors. ..
  4. Skippen A, Jones D, Morgan C, Li M, Cockcroft S. Mechanism of ADP ribosylation factor-stimulated phosphatidylinositol 4,5-bisphosphate synthesis in HL60 cells. J Biol Chem. 2002;277:5823-31 pubmed
    ..We therefore conclude that both PA derived from the PLD pathway and ARF proteins, by directly activating PIP 5-kinase, contribute to the regulation of PI(4,5)P(2) synthesis at the plasma membrane in HL60 cells. ..
  5. Benítez Rajal J, Lorite M, Burt A, Day C, Thompson M. Phospholipase D and extracellular signal-regulated kinase in hepatic stellate cells: effects of platelet-derived growth factor and extracellular nucleotides. Am J Physiol Gastrointest Liver Physiol. 2006;291:G977-86 pubmed
    ..Instead, these responses may be linked to other phenotypic changes associated with activated HSC such as increases in contraction, motility, or extracellular matrix deposition. ..
  6. Hughes W, Larijani B, Parker P. Detecting protein-phospholipid interactions. Epidermal growth factor-induced activation of phospholipase D1b in situ. J Biol Chem. 2002;277:22974-9 pubmed
    ..Application of this approach will facilitate the spatial resolution of many protein-phospholipid interactions that are key events in the regulation of cellular processes. ..
  7. O Luanaigh N, Pardo R, Fensome A, Allen Baume V, Jones D, Holt M, et al. Continual production of phosphatidic acid by phospholipase D is essential for antigen-stimulated membrane ruffling in cultured mast cells. Mol Biol Cell. 2002;13:3730-46 pubmed
    ..We conclude that both activation of ARF6 by antigen and a continual PLD2 activity are essential for local phosphatidylinositol(4,5)bisphosphate generation that regulates dynamic actin cytoskeletal rearrangements. ..
  8. Mitchell R, Robertson D, Holland P, Collins D, Lutz E, Johnson M. ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor. J Biol Chem. 2003;278:33818-30 pubmed
    ..Examples of other G protein-coupled receptors assessed in comparison display alternative pathways of protein kinase C- or ARF6-dependent activation of PLD2. ..
  9. Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, et al. Sphingosine kinase 1 is an intracellular effector of phosphatidic acid. J Biol Chem. 2004;279:44763-74 pubmed
    ..The SK1-PA interaction maps to the C terminus of SK1 and is independent of catalytic activity or of the diacylglycerol kinase-like domain of the enzyme. Thus SK1 constitutes a novel, physiologically relevant PA effector. ..

More Information


  1. Garner K, Hunt A, Koster G, Somerharju P, Groves E, Li M, et al. Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid. J Biol Chem. 2012;287:32263-76 pubmed publisher
    ..We propose that RdgB?, when containing PA, regulates an effector protein or can facilitate lipid transfer between membrane compartments. ..
  2. Hadders M, Agromayor M, Obita T, Perisic O, Caballe A, Kloc M, et al. ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes. Proc Natl Acad Sci U S A. 2012;109:17424-9 pubmed publisher
    ..These results suggest a model whereby MITD1 coordinates the activity of ESCRT-III during abscission with earlier events in the final stages of cell division. ..
  3. Pye D, Rubio I, Pusch R, Lin K, Pettitt A, Till K. Chemokine unresponsiveness of chronic lymphocytic leukemia cells results from impaired endosomal recycling of Rap1 and is associated with a distinctive type of immunological anergy. J Immunol. 2013;191:1496-504 pubmed publisher