Genomes and Genes
Experts and Doctors on phenotype in United States
Locale: United States
Publications580 found, 100 shown here
- Wang X, Yamada S, LaRiviere W, Ye H, Bakeberg J, Irazabal M, et al. Generation and phenotypic characterization of Pde1a mutant mice. PLoS ONE. 2017;12:e0181087 pubmed publisher..These results support an important role of PDE1A in the renal pathogenesis of ADPKD and in the regulation of blood pressure. ..
- Albert P, Riddle D. Mutants of Caenorhabditis elegans that form dauer-like larvae. Dev Biol. 1988;126:270-93 pubmed..The genetic tests and the mutant ultrastructure suggest that the two genes may affect parallel pathways of morphogenesis...
- Zheng Y, Felder M. Genetic mapping of a possible new alcohol dehydrogenase sequence to mouse chromosome 3 at the Adh-1/Adh-3 complex. Biochem Genet. 1997;35:105-17 pubmed..However, the new polymorphism identified in the 2.0-kb EcoRI fragment enabled this sequence to be mapped at the Adh-1/Adh-3 complex. ..
- Rupert K, Moulds J, Yang Y, Arnett F, Warren R, Reveille J, et al. The molecular basis of complete complement C4A and C4B deficiencies in a systemic lupus erythematosus patient with homozygous C4A and C4B mutant genes. J Immunol. 2002;169:1570-8 pubmed..Hence, complete C4 deficiency is one of the most penetrant genetic risk factors for human systemic lupus erythematosus. ..
- Guo H, Lee I, Bryan B, Pierce M. Deletion of mouse embryo fibroblast N-acetylglucosaminyltransferase V stimulates alpha5beta1 integrin expression mediated by the protein kinase C signaling pathway. J Biol Chem. 2005;280:8332-42 pubmed
- Johnson D, Cano K, Kroger E, McNabb D. Novel regulatory function for the CCAAT-binding factor in Candida albicans. Eukaryot Cell. 2005;4:1662-76 pubmed..These data provide the first evidence that the CCAAT-binding factor can act as a transcriptional repressor and raise new and interesting questions about how carbon metabolism is regulated in this opportunistic human pathogen. ..
- White S, Kasman L, Kelly M, Lu P, Spruill L, McDermott P, et al. Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2. Free Radic Biol Med. 2007;43:1313-21 pubmed..In conclusion, our data suggest that free radicals can affect the phosphorylation of EF-2 resulting in a net loss of short-half-life proteins such as cFLIP(S) and XIAP, leaving a cell more vulnerable to apoptotic stimuli. ..
- Fowler J, Narváez Vásquez J, Aromdee D, Pautot V, Holzer F, Walling L. Leucine aminopeptidase regulates defense and wound signaling in tomato downstream of jasmonic acid. Plant Cell. 2009;21:1239-51 pubmed publisher..Collectively, these data suggested that LAP-A has a role in modulating essential defenses against herbivores by promoting late wound responses and acting downstream of JA biosynthesis and perception. ..
- Logan J, Petrill S, Flax J, Justice L, Hou L, Bassett A, et al. Genetic covariation underlying reading, language and related measures in a sample selected for specific language impairment. Behav Genet. 2011;41:651-9 pubmed publisher..Only phonological awareness showed significant genetic correlations with all reading measures and several language measures while phonological short-term memory and auditory processing did not...
- Tebbenkamp A, Swing D, Tessarollo L, Borchelt D. Premature death and neurologic abnormalities in transgenic mice expressing a mutant huntingtin exon-2 fragment. Hum Mol Genet. 2011;20:1633-42 pubmed publisher..We conclude that the lack of an overt phenotype in the initial Shortstop mice cannot be completely explained by the properties of mutant htt N118 fragments. ..
- Borghese C, Blednov Y, Quan Y, Iyer S, Xiong W, Mihic S, et al. Characterization of two mutations, M287L and Q266I, in the ?1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther. 2012;340:304-16 pubmed publisher..The behavioral characterization of these knockin mice is presented in a companion article (J Pharmacol Exp Ther 340:317-329, 2012). ..
- Lee K, Minami A, Marshall R, Book A, Farmer L, Walker J, et al. The RPT2 subunit of the 26S proteasome directs complex assembly, histone dynamics, and gametophyte and sporophyte development in Arabidopsis. Plant Cell. 2011;23:4298-317 pubmed publisher..Like caf1 mutants, plants missing RPT2a or reduced in other RP subunits contain less histones, thus implicating RPT2 specifically, and the 26S proteasome generally, in plant nucleosome assembly. ..
- Nyflot M, Harari P, Yip S, Perlman S, Jeraj R. Correlation of PET images of metabolism, proliferation and hypoxia to characterize tumor phenotype in patients with cancer of the oropharynx. Radiother Oncol. 2012;105:36-40 pubmed publisher..These results have implications for radiotherapy target definition and provide a framework to test outcome prediction based on pretherapy distribution of phenotype. ..
- Cohen K, HUNTER L. Chapter 16: text mining for translational bioinformatics. PLoS Comput Biol. 2013;9:e1003044 pubmed publisher..Like all translational bioinformatics software, text mining software for translational bioinformatics can be considered health-critical and should be subject to the strictest standards of quality assurance and software testing. ..
- Kelly K, Reuven N, Li Z, Deutscher M. RNase PH is essential for tRNA processing and viability in RNase-deficient Escherichia coli cells. J Biol Chem. 1992;267:16015-8 pubmed..These data indicate that RNase PH can be an essential enzyme for the processing of tRNA precursors. ..
- Koonce M, Samso M. Overexpression of cytoplasmic dynein's globular head causes a collapse of the interphase microtubule network in Dictyostelium. Mol Biol Cell. 1996;7:935-48 pubmed..Similar expression of a central 107-kDa fragment of the heavy chain does not produce this result. The data presented here suggest that dynein may participate in maintaining the spatial pattern of the interphase microtubule network. ..
- Sass G, Henikoff S. Pairing-dependent mislocalization of a Drosophila brown gene reporter to a heterochromatic environment. Genetics. 1999;152:595-604 pubmed..We also find that an ensnared distal copy of bw that is interrupted by a heterochromatic insertion enhances silencing. This demonstrates that bw can be simultaneously acted upon by pericentric and distal blocks of heterochromatin...
- Huang K, D hondt K, Riezman H, Lemmon S. Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast. EMBO J. 1999;18:3897-908 pubmed..Therefore, alternative mechanisms for clathrin assembly and coated vesicle formation, as well as the role of AP complexes and AP180-related proteins in these processes, must be considered. ..
- Barresi M, Stickney H, Devoto S. The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity. Development. 2000;127:2189-99 pubmed..Therefore, Hedgehog signaling through Slow-muscle-omitted is necessary for slow muscle fiber type development. We propose that smu encodes a vital component in the Hedgehog response pathway. ..
- Kang B, Busse J, Dickey C, Rancour D, Bednarek S. The arabidopsis cell plate-associated dynamin-like protein, ADL1Ap, is required for multiple stages of plant growth and development. Plant Physiol. 2001;126:47-68 pubmed..We discuss the putative role of ADL1Ap in vesicular trafficking, cytokinesis, and other aspects of plant growth. ..
- Kuhl J, Hanneman R, Havey M. Characterization and mapping of Rpi1, a late-blight resistance locus from diploid (1EBN) Mexican Solanum pinnatisectum. Mol Genet Genomics. 2001;265:977-85 pubmed..Characterization of the P.infestans isolate used for disease evaluations revealed that it possessed the avirulence gene corresponding to the R9 resistance locus, indicating that Rpi1 could possibly correspond to R9...
- Mailman M, Heinz J, Papp A, Snyder P, Sedra M, Wirth B, et al. Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2. Genet Med. 2002;4:20-6 pubmed publisher..Screening for intragenic mutations in SMN1 increases the sensitivity of diagnostic testing. Finally, SMN2 copy number is conclusively shown to ameliorate the phenotype and provide valuable prognostic information. ..
- Shih Y, Fu X, King G, Le T, Rothfield L. Division site placement in E.coli: mutations that prevent formation of the MinE ring lead to loss of the normal midcell arrest of growth of polar MinD membrane domains. EMBO J. 2002;21:3347-57 pubmed publisher..The results suggested that the MinE ring acts as a stop-growth mechanism to prevent the MinCD polar zone from extending beyond the midcell division site...
- Milliken E, Ameduri R, Landis M, Behrooz A, Abdul Karim F, Keri R. Ovarian hyperstimulation by LH leads to mammary gland hyperplasia and cancer predisposition in transgenic mice. Endocrinology. 2002;143:3671-80 pubmed..This mouse model likely holds great potential as a tool for discovery of hormone-mediated mechanisms of breast cancer and identification of future targets for breast cancer prevention and treatment. ..
- Mukhopadhyay M, Teufel A, Yamashita T, Agulnick A, Chen L, Downs K, et al. Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development. 2003;130:495-505 pubmed..The expression of several Wnt inhibitors is curtailed in the mutant, suggesting that Wnt pathways may be involved in axial patterning regulated by Ldb1. ..
- Yang Y, Lacas Gervais S, Morest D, Solimena M, Rasband M. BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier. J Neurosci. 2004;24:7230-40 pubmed..These results show that quivering mutations disrupt betaIV spectrin retention and stability at nodes and that distinct protein domains regulate nodal structural integrity and molecular organization. ..
- Hsieh F, Sharma P, Gibbons A, Goggans T, Erzurum S, Haque S. Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells. Proc Natl Acad Sci U S A. 2005;102:14380-5 pubmed..Thus, distinct cell types may direct unique aspects of reactive mucosal MC phenotype in the airways. ..
- Bissonnette J, Knopp S. Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Pediatr Res. 2006;59:513-8 pubmed..Taken together these results indicate that the depression is due to hypocapnia. Respiratory depression in this mouse model of Rett Syndrome is seen in with ubiquitous deficiency in Mecp2 but not when it is confined to neurons. ..
- Zhou X, Wheeler M, Oi F, Scharf M. RNA interference in the termite Reticulitermes flavipes through ingestion of double-stranded RNA. Insect Biochem Mol Biol. 2008;38:805-15 pubmed publisher..Additionally, these results validate a high-throughput bioassay approach for use in (i) termite functional genomics research, and (ii) characterizing target sites of conventional and novel RNAi-based termiticides. ..
- Haskell Luevano C, Schaub J, Andreasen A, Haskell K, Moore M, Koerper L, et al. Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. FASEB J. 2009;23:642-55 pubmed publisher..These data support the hypothesis that voluntary exercise can prevent the genetic predisposition of melanocortin-4 receptor-associated obesity and diabetes. ..
- Taccioli C, Wan S, Liu C, Alder H, Volinia S, Farber J, et al. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology. 2009;136:953-66 pubmed publisher..The finding that zinc regulates an inflammatory pathway in esophageal carcinogenesis may lead to prevention and therapy for this cancer. ..
- Zhang J, Wilson G, Soerens A, Koonce C, Yu J, Palecek S, et al. Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res. 2009;104:e30-41 pubmed publisher..We conclude that human iPS cells can differentiate into functional cardiomyocytes, and thus iPS cells are a viable option as an autologous cell source for cardiac repair and a powerful tool for cardiovascular research. ..
- Pappas P, Lal B, Ohara N, Saito S, Zapiach L, Duran W. Regulation of matrix contraction in chronic venous disease. Eur J Vasc Endovasc Surg. 2009;38:518-29 pubmed publisher..These data identify potentially clinically relevant therapeutic molecular targets that could enhance matrix contraction and thereby improve venous ulcer wound healing. ..
- Blaby Haas C, De Crecy Lagard V. Mining high-throughput experimental data to link gene and function. Trends Biotechnol. 2011;29:174-82 pubmed publisher..To this end, we review recent advances in generating whole-genome experimental datasets, where this data can be accessed, and how it can be used to drive prediction of gene function. ..
- Yokoi F, Dang M, Zhou T, Li Y. Abnormal nuclear envelopes in the striatum and motor deficits in DYT11 myoclonus-dystonia mouse models. Hum Mol Genet. 2012;21:916-25 pubmed publisher..Development of therapies targeting the striatum to compensate for the loss of ?-sarcoglycan function may rescue the motor deficits in DYT11 M-D patients. ..
- Crissey J, Jenkins N, Lansford K, Thorne P, Bayless D, Vieira Potter V, et al. Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats. Am J Physiol Regul Integr Comp Physiol. 2014;306:R596-606 pubmed publisher..Collectively, we show in OLETF rats that lower adiposity leads to less AT and aortic inflammation, as well as an exercise-specific improvement in insulin-stimulated vasorelaxation...
- Romick Rosendale L, Hoskins E, Privette Vinnedge L, Foglesong G, Brusadelli M, Potter S, et al. Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. Clin Cancer Res. 2016;22:2062-73 pubmed publisher..These findings demonstrate that FA loss stimulates HNSCC cell motility and invasion, and implicate a targetable DNA-PK/Rac1 signaling axis in advanced tumor phenotypes. ..
- Grams S, Argiropoulos B, Lines M, Chakraborty P, McGowan Jordan J, Geraghty M, et al. Genotype-phenotype characterization in 13 individuals with chromosome Xp11.22 duplications. Am J Med Genet A. 2016;170A:967-77 pubmed publisher..In addition, expressive language delay, failure to thrive, motor delay, and 5th finger clinodactyly were also frequently observed in patients with the proximal duplication. ..
- Turkowski K, Tester D, Bos J, Haugaa K, Ackerman M. Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy. Congenit Heart Dis. 2017;12:226-235 pubmed publisher..Herein, it is demonstrated that genetic mutations in CDH2-encoded N-cadherin may represent a novel pathogenetic basis for ACM in humans. The prevalence of CDH2-mediated ACM in heretofore genetically elusive ACM remains to be determined. ..
- Baughman J, Payton A, Paasch A, Fisher K, McDaniel S. Multiple factors influence population sex ratios in the Mojave Desert moss Syntrichia caninervis. Am J Bot. 2017;104:733-742 pubmed publisher..caninervis. ..
- Jones H, Yehia B, Chen G, Carter B. Genetic analysis of inherited hydrocephalus in a rat model. Exp Neurol. 2004;190:79-90 pubmed..Future studies to characterize the causative genes in this animal model will improve the understanding of genetic causes in humans. ..
- Compton D. Chromosome orientation. J Cell Biol. 2007;179:179-81 pubmed..Some clarity is now emerging with the identification of Bod1 (Biorientation Defective 1), a protein that promotes chromosome biorientation by unleashing chromosomes from improperly oriented microtubule attachments. ..
- Weissman J, Kelley R, Bauman M, Cohen B, Murray K, Mitchell R, et al. Mitochondrial disease in autism spectrum disorder patients: a cohort analysis. PLoS ONE. 2008;3:e3815 pubmed publisher..These and prior data suggest a disturbance of mitochondrial energy production as an underlying pathophysiological mechanism in a subset of individuals with autism. ..
- Guo Z, Nelson J. Multiple-trait quantitative trait locus mapping with incomplete phenotypic data. BMC Genet. 2008;9:82 pubmed publisher..It may be incorporated into any least-squares or likelihood-maximization QTL-mapping approach. ..
- Jeon M, Zinn K. Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signaling. Development. 2009;136:3121-9 pubmed publisher..PTPRJ corresponds to the murine Scc1 (suppressor of colon cancer) gene. ..
- Banuelos M, Moreno D, Olson D, Nguyen Q, Ricarte F, Aguilera Sandoval C, et al. Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae. Curr Genet. 2010;56:121-37 pubmed publisher..Thus, our results support linkage between severe hypersensitivity to hygromycin B and vacuolar defects. ..
- Boucek D, Jirikowic J, Taylor M. Natural history of Danon disease. Genet Med. 2011;13:563-8 pubmed publisher..Women with Danon disease present with clinical symptoms and events approximately 15 years after men and report a higher proportion of cognitive and skeletal muscle problems than previously recognized. ..
- Shen H, Zhu L, Bu Q, Huq E. MAX2 affects multiple hormones to promote photomorphogenesis. Mol Plant. 2012;5:750-62 pubmed publisher..Taken together, these data suggest that MAX2 modulates multiple hormone pathways to affect photomorphogenesis. ..
- Jezierska Drutel A, Rosenzweig S, Neumann C. Role of oxidative stress and the microenvironment in breast cancer development and progression. Adv Cancer Res. 2013;119:107-25 pubmed publisher..This review describes how breast cancer progression is dependent upon oxidative stress activated stroma and proposes potential new therapeutic avenues. ..
- Cannon D, Medina T, Mermelstein R, Hedeker D, Bakian A, Coon H, et al. CYP2A6 Longitudinal Effects in Young Smokers. Nicotine Tob Res. 2016;18:196-203 pubmed publisher..However, differences in the time-by-CDPR effects result in a reordering of genotype effects such that normal metabolism becomes the risk variant by young adulthood, as has been reliably reported in older smokers. ..
- Freedman B, Pastan S, Israni A, Schladt D, Julian B, Gautreaux M, et al. APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors. Transplantation. 2016;100:194-202 pubmed publisher..Shorter renal allograft survival is reproducibly observed after DDKT from APOL1 2-renal-risk-variant donors. Younger recipient age and older donor age have independent adverse effects on renal allograft survival. ..
- Zheng S, Coventry S, Cai L, Powell D, Jala V, Haribabu B, et al. Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice. J Diabetes Res. 2016;2016:5362506 pubmed publisher..Unexpectedly, ACKR2 deletion reduced renal inflammation in diabetes and the ultimate response was a high degree of protection from diabetic nephropathy. ..
- Bouchet S, Olatoye M, Marla S, Perumal R, Tesso T, Yu J, et al. Increased Power To Dissect Adaptive Traits in Global Sorghum Diversity Using a Nested Association Mapping Population. Genetics. 2017;206:573-585 pubmed publisher..i> association mapping with a diverse panel. These findings validate the NAM resource for trait mapping in sorghum, and demonstrate the value of NAM for dissection of adaptive traits. ..
- Namciu S, Blochlinger K, Fournier R. Human matrix attachment regions insulate transgene expression from chromosomal position effects in Drosophila melanogaster. Mol Cell Biol. 1998;18:2382-91 pubmed..In contrast, expression of white transgenes containing human DNA segments without matrix-binding activity was highly variable in Drosophila transformants. These data indicate that human MARs can function as insulator elements in vivo...
- Fernandez D, Heck G, Perry S, Patterson S, Bleecker A, Fang S. The embryo MADS domain factor AGL15 acts postembryonically. Inhibition of perianth senescence and abscission via constitutive expression. Plant Cell. 2000;12:183-98 pubmed..Abscission-associated gene expression and structural changes were also altered in the presence of ectopic AGL15. ..
- Ciche T, Bintrim S, Horswill A, Ensign J. A Phosphopantetheinyl transferase homolog is essential for Photorhabdus luminescens to support growth and reproduction of the entomopathogenic nematode Heterorhabditis bacteriophora. J Bacteriol. 2001;183:3117-26 pubmed..Possible roles of a Ppant transferase in the ability of P. luminescens to support nematode growth and reproduction are discussed...
- Brodkin E, Goforth S, Keene A, Fossella J, Silver L. Identification of quantitative trait Loci that affect aggressive behavior in mice. J Neurosci. 2002;22:1165-70 pubmed
- Harris T, Shelver D, Bohnsack J, Rubens C. A novel streptococcal surface protease promotes virulence, resistance to opsonophagocytosis, and cleavage of human fibrinogen. J Clin Invest. 2003;111:61-70 pubmed publisher..Taken together, the results suggest that cleavage of fibrinogen by CspA may increase the lethality of GBS infection, potentially by protecting the bacterium from opsonophagocytic killing...
- Varela A, Luttrell M, Howerth E, Moore V, Davidson W, Stallknecht D, et al. First culture isolation of Borrelia lonestari, putative agent of southern tick-associated rash illness. J Clin Microbiol. 2004;42:1163-9 pubmed..lonestari in culture, providing a much needed source of organisms for the development of diagnostic assays and forming a basis for future studies investigating the role of the organism as a human disease agent. ..
- Rosenthal D, Rieseberg L, Donovan L. Re-creating ancient hybrid species' complex phenotypes from early-generation synthetic hybrids: three examples using wild sunflowers. Am Nat. 2005;166:26-41 pubmed..Our results demonstrate past hybridization could have generated hybrid species-like multitrait phenotypes suitable for persistence in their respective environments in just three generations after initial hybridization. ..
- Liu X, Kim Y, Muller R, Yumul R, Liu C, Pan Y, et al. AGAMOUS terminates floral stem cell maintenance in Arabidopsis by directly repressing WUSCHEL through recruitment of Polycomb Group proteins. Plant Cell. 2011;23:3654-70 pubmed publisher..Our studies identify core components of the network governing the temporal program of floral stem cells...
- Jasrapuria S, Specht C, Kramer K, Beeman R, Muthukrishnan S. Gene families of cuticular proteins analogous to peritrophins (CPAPs) in Tribolium castaneum have diverse functions. PLoS ONE. 2012;7:e49844 pubmed publisher..This is the first comprehensive functional analysis of an entire class of cuticular proteins with one or more ChtBD2 domains in any insect species. ..
- Millner L, Linder M, Valdes R. Circulating tumor cells: a review of present methods and the need to identify heterogeneous phenotypes. Ann Clin Lab Sci. 2013;43:295-304 pubmed..Lastly, we provide insight into what is required to overcome these limitations as they relate to applications in advancing the practice of pathology and laboratory medicine. ..
- Murray S. Cell-intrinsic role for NF-kappa B-inducing kinase in peripheral maintenance but not thymic development of Foxp3+ regulatory T cells in mice. PLoS ONE. 2013;8:e76216 pubmed publisher..These results demonstrate a novel role for NIK in peripheral regulatory and memory phenotype T cell homeostasis. ..
- Beam C, Turkheimer E, Dickens W, Davis D. Twin Differentiation of Cognitive Ability Through Phenotype to Environment Transmission: The Louisville Twin Study. Behav Genet. 2015;45:622-34 pubmed publisher..The results suggest that a Pâ‡’E model provided better fit to twins' FSIQ data than a genetic simplex model and the meaning of the nonshared environment was preserved in the context of Pâ‡’E. ..
- Landrian I, McFarland K, Liu J, Mulligan C, Rasmussen A, Ashizawa T. Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 (SCA10) expansions. PLoS ONE. 2017;12:e0175958 pubmed publisher..In addition, analysis of the interruption alleles across these families support a parsimonious single origin of the mutation with a shared distant ancestor. ..
- Dunlap J. Closely watched clocks: molecular analysis of circadian rhythms in Neurospora and Drosophila. Trends Genet. 1990;6:159-65 pubmed..In related work, the recent identification and molecular analysis of clock-controlled genes is revealing how biological clocks control gene expression, and may pave the way for the isolation of novel 'clock genes' in the future. ..
- Patapoutian A, Yoon J, Miner J, Wang S, Stark K, Wold B. Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome. Development. 1995;121:3347-58 pubmed..Finally, a later and relatively mild phenotype was detected in intercostal muscles of newborn animals. ..
- Dhar M, Webb L, Smith L, Hauser L, Johnson D, West D. A novel ATPase on mouse chromosome 7 is a candidate gene for increased body fat. Physiol Genomics. 2000;4:93-100 pubmed..The unusual inheritance pattern of this phenotype suggests either genomic imprinting, known to occur in other local genes (Ube3a, Ipw), or an effect of maternal haploinsufficiency during pregnancy or lactation on body fat in the progeny...
- Weinig C, Delph L. Phenotypic plasticity early in life constrains developmental responses later. Evolution. 2001;55:930-6 pubmed..The reduced responsiveness of elongated seedlings to R:FR appeared to result from a structural feedback mechanism, indicating that the opportunity cost of early responses may be lower in environments providing structural support. ..
- Boman A, Salo P, Hauglund M, Strand N, Rensink S, Zhdankina O. ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization. Mol Biol Cell. 2002;13:3078-95 pubmed..Whereas mammalian GGAs must interact with ARF to localize to and function at the Golgi, interaction between yeast Ggas and Arf plays a minor role in Gga localization and function. ..
- Bartke A, Brown Borg H. Life extension in the dwarf mouse. Curr Top Dev Biol. 2004;63:189-225 pubmed..An important role of IGF-1 and insulin in the control of mammalian longevity is consistent with the well-documented actions of homologous signaling pathways in invertebrates. ..
- Zineh I, Beitelshees A, Gaedigk A, Walker J, Pauly D, Eberst K, et al. Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension. Clin Pharmacol Ther. 2004;76:536-44 pubmed..However, there was no association between variable pharmacokinetics or CYP2D6 genotype and beta-blocker-induced adverse effects or efficacy. ..
- Whitman S, Liu S, Vukosavljevic T, Rush L, Yu L, Liu C, et al. The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy. Blood. 2005;106:345-52 pubmed
- Shumake J, Barrett D, Gonzalez Lima F. Behavioral characteristics of rats predisposed to learned helplessness: reduced reward sensitivity, increased novelty seeking, and persistent fear memories. Behav Brain Res. 2005;164:222-30 pubmed..This behavioral phenotype is discussed as resembling the personality of humans vulnerable to post-traumatic stress disorder. ..
- Haase E, Bonstein T, Palmer R, Scannapieco F. Environmental influences on Actinobacillus actinomycetemcomitans biofilm formation. Arch Oral Biol. 2006;51:299-314 pubmed..In conclusion, strain, growth medium and conditioning film all affect biofilm formation. The RVs produce biofilms of unique architecture that may serve to protect the bacterium from environmental perturbations. ..
- Lewis M, Tanimura Y, Lee L, Bodfish J. Animal models of restricted repetitive behavior in autism. Behav Brain Res. 2007;176:66-74 pubmed..As mutant mouse models continue to proliferate, there should be a number of promising genetic models to pursue. ..
- Kang L, Wang Y, Suckow A, Czymmek K, Cooke V, Naik U, et al. Deletion of JAM-A causes morphological defects in the corneal epithelium. Int J Biochem Cell Biol. 2007;39:576-85 pubmed..In summary, JAM-A is expressed in the corneal epithelium where it appears to regulate cell shape. ..
- Zheng L, Njauw C, Martins Green M. A one-plasmid conditional color-switching transgenic system for multimodal bioimaging. Transgenic Res. 2008;17:741-7 pubmed publisher..Our strategy provides time-saving features in tissue-specific transgene expression, bioimaging and primary cell isolation and can be used for generation of gene-specific transgenic mice. ..
- Au N, Rettie A. Pharmacogenomics of 4-hydroxycoumarin anticoagulants. Drug Metab Rev. 2008;40:355-75 pubmed..This article will review recent events in these and other related areas. ..
- Kim J, Miller V, Levites Y, West K, Zwizinski C, Moore B, et al. BRI2 (ITM2b) inhibits Abeta deposition in vivo. J Neurosci. 2008;28:6030-6 pubmed publisher..These studies demonstrate that BRI2 is a novel mediator of Abeta deposition in vivo. ..
- Wollenberg M, Ruby E. Population structure of Vibrio fischeri within the light organs of Euprymna scolopes squid from Two Oahu (Hawaii) populations. Appl Environ Microbiol. 2009;75:193-202 pubmed publisher..The stability of the luminous-bacterium-sepiolid squid mutualism in the presence of a polyclonal symbiont population structure is discussed in the context of contemporary evolutionary theory. ..