Experts and Doctors on phenotype in Sweden


Locale: Sweden
Topic: phenotype

Top Publications

  1. Rimpil inen M, Forsberg A, Wolf Watz H. A novel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis shows extensive homology to YopH. J Bacteriol. 1992;174:3355-63 pubmed
    ..The LcrQ protein was recovered from the culture supernatant. LcrQ shows 42% identity to the first 128 amino acids of the YopH virulence protein...
  2. DasGupta S, Bernander R, Nordstrom K. In vivo effect of the tus mutation on cell division in an Escherichia coli strain where chromosome replication is under the control of plasmid R1. Res Microbiol. 1991;142:177-80 pubmed
  3. Penha Gonçalves C, Leijon K, Persson L, Holmberg D. Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6. Genomics. 1995;28:398-404 pubmed
    ..46) and accounts for 14% of the phenotypic variation. This chromosomal region contains the diabetes susceptibility locus Idd6, suggesting that the apoptosis-resistance phenotype constitutes a pathogenesis factor in IDDM of NOD mice. ..
  4. Leveen P, Pekny M, Gebre Medhin S, Swolin B, Larsson E, Betsholtz C. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev. 1994;8:1875-87 pubmed
    ..Their hematological status includes erythroblastosis, macrocytic anemia, and thrombocytopenia. On the basis of these findings, we conclude that PDGF B has crucial roles in vivo in establishing certain renal and circulatory functions. ..
  5. Farbos I, Mouras A, Bereterbide A, Glimelius K. Defective cell proliferation in the floral meristem of alloplasmic plants of Nicotiana tabacum leads to abnormal floral organ development and male sterility. Plant J. 2001;26:131-42 pubmed
    ..The putative causes of reduced cell number in the floral meristem and the consequences for floral development are discussed. ..
  6. Toresson H, Campbell K. A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice. Development. 2001;128:4769-80 pubmed
  7. Li H, Groop L, Nilsson A, Weng J, Tuomi T. A combination of human leukocyte antigen DQB1*02 and the tumor necrosis factor alpha promoter G308A polymorphism predisposes to an insulin-deficient phenotype in patients with type 2 diabetes. J Clin Endocrinol Metab. 2003;88:2767-74 pubmed
    ..However, we could show an association between TNF alpha(308) polymorphism and the phenotype of common type 2 diabetes. ..
  8. Bengtsson Ellmark S, Nilsson J, Orho Melander M, Dahlenborg K, Groop L, Bjursell G. Association between a polymorphism in the carboxyl ester lipase gene and serum cholesterol profile. Eur J Hum Genet. 2004;12:627-32 pubmed
    ..This gives support to the notion that CEL may be involved in determining the plasma lipid composition. ..
  9. Falconer H, Andersson E, Aanesen A, Fried G. Follicle-stimulating hormone receptor polymorphisms in a population of infertile women. Acta Obstet Gynecol Scand. 2005;84:806-11 pubmed

More Information

Publications204 found, 100 shown here

  1. Ceplitis A, Su Y, Lascoux M. Bayesian inference of evolutionary history from chloroplast microsatellites in the cosmopolitan weed Capsella bursa-pastoris (Brassicaceae). Mol Ecol. 2005;14:4221-33 pubmed
    ..Finally, our results also indicate that mononucleotide repeat loci in the chloroplast genome can deteriorate in relatively short periods of evolutionary time...
  2. Gutierrez L, Bussell J, Pacurar D, Schwambach J, Pacurar M, Bellini C. Phenotypic plasticity of adventitious rooting in Arabidopsis is controlled by complex regulation of AUXIN RESPONSE FACTOR transcripts and microRNA abundance. Plant Cell. 2009;21:3119-32 pubmed publisher
    ..These results provide evidence of microRNA control of phenotypic variability and are a significant step forward in understanding the molecular mechanisms regulating adventitious rooting. ..
  3. Mörck C, Olsen L, Kurth C, Persson A, Storm N, Svensson E, et al. Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2009;106:18285-90 pubmed publisher
    ..2 substrates, resulting in developmental arrest in C. elegans. These results provide a mechanism for the pleiotropic effects of statins and suggest that statins could be used clinically where UPR activation may be of therapeutic benefit. ..
  4. Wejheden C, Brunnberg S, Larsson S, Lind P, Lind P, Andersson G, et al. Transgenic mice with a constitutively active aryl hydrocarbon receptor display a gender-specific bone phenotype. Toxicol Sci. 2010;114:48-58 pubmed publisher
    ..Female bone tissue appears more susceptible to dioxins and other AhR ligands than male bone tissue. ..
  5. Jansson D, Persson M, Zimmerman U, Johansson K. Phenotypic and genetic diversity among intestinal spirochaetes (genus Brachyspira) in free-living wild mallards (Anas platyrhynchos) sampled in southern Sweden. Syst Appl Microbiol. 2011;34:566-75 pubmed publisher
    ..A culture technique based on filtration that produced uncontaminated spirochaete isolates was described. The results show that mallard intestines support a high degree of biodiversity among Brachyspira spp. ..
  6. Johansson C, Gothe S, Forrest D, Vennstrom B, Thoren P. Cardiovascular phenotype and temperature control in mice lacking thyroid hormone receptor-beta or both alpha1 and beta. Am J Physiol. 1999;276:H2006-12 pubmed
    ..Our present and previous results support the hypothesis that TR-alpha1 has a major role in determining heart rate under baseline conditions and body temperature and that TR-beta mediates a hormone-induced increase in heart rate. ..
  7. Tentler D, Gustavsson P, Elinder G, Eklöf O, Gordon L, Mandel A, et al. A microdeletion in 19q13.2 associated with mental retardation, skeletal malformations, and Diamond-Blackfan anaemia suggests a novel contiguous gene syndrome. J Med Genet. 2000;37:128-31 pubmed
    ..In combination, the clinical and molecular findings suggest a contiguous gene syndrome with a gene locus for mental retardation and, probably, skeletal malformations included in the deletion. ..
  8. Brunberg E, Andersson L, Cothran G, Sandberg K, Mikko S, Lindgren G. A missense mutation in PMEL17 is associated with the Silver coat color in the horse. BMC Genet. 2006;7:46 pubmed
    ..The present study shows that PMEL17 causes the Silver coat color in the horse and enable genetic testing for this trait. ..
  9. Ellegren H. Comparative genomics and the study of evolution by natural selection. Mol Ecol. 2008;17:4586-96 pubmed publisher
    ..Finally, genome sequencing using outbred or multiple individuals has provided a wealth of polymorphism data that gives information on population history, demography and marker evolution. ..
  10. Andersson S, Saebøe Larssen S, Lambertsson A, Merriam J, Jacobs Lorena M. A Drosophila third chromosome Minute locus encodes a ribosomal protein. Genetics. 1994;137:513-20 pubmed
    ..At the amino acid level, the overall identity is approximately 78% for all three species. This is only the second time that a Minute has been demonstrated to encode a ribosomal protein. ..
  11. Larsson N, Marklund U, Gradin H, Brattsand G, Gullberg M. Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis. Mol Cell Biol. 1997;17:5530-9 pubmed
    ..Subsequent phosphorylation of either Ser-16, Ser-63, or both efficiently switches off Op18 activity. ..
  12. Ramne A, Bilsland Marchesan E, Erickson S, Sunnerhagen P. The protein kinases Rck1 and Rck2 inhibit meiosis in budding yeast. Mol Gen Genet. 2000;263:253-61 pubmed
    ..There is a transient shift in the relative abundance of the two RCK2 transcripts in meiotic cells. We propose that one function of Rck1 and Rck2 is to inhibit meiosis. ..
  13. Brown R, Ollerstam A, Johansson B, Skøtt O, Gebre Medhin S, Fredholm B, et al. Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2001;281:R1362-7 pubmed
    ..3 milli-Goldblatt units (mGU)/ml] mice compared with the wild-type and A1R+/- mice (36.3 +/- 8.5 and 34.1 +/- 9.6 mGU/ml), respectively. The results demonstrate that adenosine acting on A1R is required for TGF and modulates renin release...
  14. Ormestad M, Blixt A, Churchill A, Martinsson T, Enerback S, Carlsson P. Foxe3 haploinsufficiency in mice: a model for Peters' anomaly. Invest Ophthalmol Vis Sci. 2002;43:1350-7 pubmed
    ..To evaluate the importance in anterior segment dysgenesis of genetic variation in Foxe3, a gene encoding a forkhead transcription factor specifically expressed in the lens...
  15. Makino Y, Kanopka A, Wilson W, Tanaka H, Poellinger L. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. J Biol Chem. 2002;277:32405-8 pubmed
    ..Importantly, this mechanism may establish negative feedback loop regulation of adaptive responses to hypoxia/ischemia in these tissues. ..
  16. Zhu Y, Brannstrom M, Janson P, Sundfeldt K. Differences in expression patterns of the tight junction proteins,claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours. Int J Cancer. 2006;118:1884-91 pubmed
    ..The observations of lack of claudin 4 and low expression of claudin 3 in OSE strengthen our current knowledge about the biological nature of these cells as an undeveloped epithelium. ..
  17. Lundin B, Hansson M, Schoefs B, Vener A, Spetea C. The Arabidopsis PsbO2 protein regulates dephosphorylation and turnover of the photosystem II reaction centre D1 protein. Plant J. 2007;49:528-39 pubmed
  18. Green H, Söderkvist P, Rosenberg P, Horvath G, Peterson C. ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel. J Pharm Sci. 2008;97:2045-8 pubmed
    ..Genotyping of the ABCB1 gene may be important for determining the tumor resistance to paclitaxel and provide useful information for individualized therapy. ..
  19. Bernspång E, Wollmer P, Sveger T, Piitulainen E. Lung function in 30-year-old alpha-1-antitrypsin-deficient individuals. Respir Med. 2009;103:861-5 pubmed publisher
    ..05). AAT-deficient individuals identified by neonatal screening have normal lung function at the age of 30. The PiZZ smokers had changes in lung function that may be signs of early emphysema. ..
  20. Kitambi S, McCulloch K, Peterson R, Malicki J. Small molecule screen for compounds that affect vascular development in the zebrafish retina. Mech Dev. 2009;126:464-77 pubmed
    ..This work demonstrates the utility of zebrafish as a screening tool for small molecules that affect eye vasculature and presents several compounds of potential therapeutic importance. ..
  21. Hudecova M, Holte J, Olovsson M, Larsson A, Berne C, Sundström Poromaa I. Prevalence of the metabolic syndrome in women with a previous diagnosis of polycystic ovary syndrome: long-term follow-up. Fertil Steril. 2011;96:1271-4 pubmed publisher
    ..8%; resolved PCOS: 16.7%). The MetS occurred more often in patients with PCOS than in controls and did not depend on phenotypic presentation at the index assessment or the persistence of PCOS at follow-up. ..
  22. Mishra Y, Jänkänpää H, Kiss A, Funk C, Schröder W, Jansson S. Arabidopsis plants grown in the field and climate chambers significantly differ in leaf morphology and photosystem components. BMC Plant Biol. 2012;12:6 pubmed publisher
    ..Our results indicate that comparative analysis of field-grown plants with those grown under artificial conditions is important for a full understanding of plant plasticity and adaptation. ..
  23. Busayavalasa K, Chen X, Farrants A, Wagner N, Sabri N. The Nup155-mediated organisation of inner nuclear membrane proteins is independent of Nup155 anchoring to the metazoan nuclear pore complex. J Cell Sci. 2012;125:4214-8 pubmed publisher
  24. Savitsky M, Kim M, Kravchuk O, Schwartz Y. Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex. Genetics. 2016;202:601-17 pubmed publisher
  25. Sköld H, Aspengren S, Cheney K, Wallin M. Fish Chromatophores--From Molecular Motors to Animal Behavior. Int Rev Cell Mol Biol. 2016;321:171-219 pubmed publisher
    ..In this cross-disciplinary review, we have highlighted emerging trends in pigment cell research and identified unsolved problems for future research. ..
  26. Ek F, Malo M, Ã…berg Andersson M, Wedding C, Kronborg J, Svensson P, et al. Behavioral Analysis of Dopaminergic Activation in Zebrafish and Rats Reveals Similar Phenotypes. ACS Chem Neurosci. 2016;7:633-46 pubmed publisher
    ..Molecular modeling of dopamine D2 and D4 receptors indicated that nonconserved amino acids have limited influence on important ligand-receptor interactions. ..
  27. Wehtje C, Beijer L, Nilsson R, Rutberg B. Mutations in the glycerol kinase gene restore the ability of a ptsGHI mutant of Bacillus subtilis to grow on glycerol. Microbiology. 1995;141 ( Pt 5):1193-8 pubmed
    ..The results strongly suggest that the main effect of the PTS on glycerol utilization in B. subtilis is mediated via glycerol kinase. ..
  28. Holm B, Xu H, Jacobsson L, Larsson A, Luthman H, Lorentzen J. Rats made congenic for Oia3 on chromosome 10 become susceptible to squalene-induced arthritis. Hum Mol Genet. 2001;10:565-72 pubmed
    ..The experimental system described allows transformation of multifactorial arthritis susceptibility into dichotomous phenotypes. ..
  29. Francis M, Lloyd S, Wolf Watz H. The type III secretion chaperone LcrH co-operates with YopD to establish a negative, regulatory loop for control of Yop synthesis in Yersinia pseudotuberculosis. Mol Microbiol. 2001;42:1075-93 pubmed
    ..We suggest that LcrH can exhibit both of these activities. ..
  30. Lundgren J, Masson P, Realini C, Young P. Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13. Mol Cell Biol. 2003;23:5320-30 pubmed
    ..The S13 subunit may possess multiple functions, including a deubiquitinylating activity and distinct activities essential for cell cycle progression that require the conserved C120 residue. ..
  31. Baghaei F, Rosmond R, Landen M, Westberg L, Hellstrand M, Holm G, et al. Phenotypic and genotypic characteristics of women in relation to personality traits. Int J Behav Med. 2003;10:365-78 pubmed
    ..It was concluded that a majority of women showed M type of personality traits, associated with normal hormones, somatic health, and a long microsatellite in the transactivating domain of the AR gene. ..
  32. Pierson J, Norris J, Aerni H, Svenningsson P, Caprioli R, Andren P. Molecular profiling of experimental Parkinson's disease: direct analysis of peptides and proteins on brain tissue sections by MALDI mass spectrometry. J Proteome Res. 2004;3:289-95 pubmed
  33. Salmon Hillbertz N, Isaksson M, Karlsson E, Hellmén E, Pielberg G, Savolainen P, et al. Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Nat Genet. 2007;39:1318-20 pubmed
    ..FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development...
  34. Bilde T, Friberg U, Maklakov A, Fry J, Arnqvist G. The genetic architecture of fitness in a seed beetle: assessing the potential for indirect genetic benefits of female choice. BMC Evol Biol. 2008;8:295 pubmed publisher
    ..We discuss the processes that may maintain additive and non-additive genetic variance for fitness and how these relate to indirect selection for female choice. ..
  35. Bäckdahl L, Guo J, Jagodic M, Becanovic K, Ding B, Olsson T, et al. Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case-control association data. Ann Rheum Dis. 2009;68:1925-32 pubmed publisher
    ..High-resolution mapping in AIL populations defines limited sets of candidate risk genes, some of which appear also to associate with RA and thus may give clues to evolutionarily conserved pathways that lead to arthritis. ..
  36. Kollberg G, Tulinius M, Melberg A, Darin N, Andersen O, Holmgren D, et al. Clinical manifestation and a new ISCU mutation in iron-sulphur cluster deficiency myopathy. Brain. 2009;132:2170-9 pubmed publisher
    ..There was only a slight reduction of mitochondrial IscU in the compound heterozygotes, despite their severe phenotype, indicating that the IscU expressed in these patients is non-functional...
  37. Kołtowska Häggström M, Geffner M, Jonsson P, Monson J, Abs R, Hana V, et al. Discontinuation of growth hormone (GH) treatment during the transition phase is an important factor determining the phenotype of young adults with nonidiopathic childhood-onset GH deficiency. J Clin Endocrinol Metab. 2010;95:2646-54 pubmed publisher
    ..Little is known about the impact of childhood-onset GH deficiency (GHD), in particular the duration of GH cessation during the transition phase, on adult phenotype...
  38. Hallgren O, Nihlberg K, Dahlbäck M, Bjermer L, Eriksson L, Erjefalt J, et al. Altered fibroblast proteoglycan production in COPD. Respir Res. 2010;11:55 pubmed publisher
    ..In addition, a lower perlecan production in centrally derived fibroblasts from COPD patients may indicate alterations in bronchial basement membrane integrity in severe COPD. ..
  39. Ma X, Hall D, Onge K, Jansson S, Ingvarsson P. Genetic differentiation, clinal variation and phenotypic associations with growth cessation across the Populus tremula photoperiodic pathway. Genetics. 2010;186:1033-44 pubmed publisher
    ..Collectively these SNPs explain 10-15% of the phenotypic variation in growth cessation. Covariances in allelic effects across populations help explain an additional 5-7% of the phenotypic variation in growth cessation. ..
  40. Mardinoglu A, Nielsen J. Systems medicine and metabolic modelling. J Intern Med. 2012;271:142-54 pubmed publisher
    ..In this review, we outline the importance of genome-scale models in systems medicine and discuss how they may contribute towards the development of personalized medicine. ..
  41. Markljung E, Adamovic T, Cao J, Naji H, Kaiser S, Wester T, et al. Novel mutations in the MNX1 gene in two families with Currarino syndrome and variable phenotype. Gene. 2012;507:50-3 pubmed publisher
    ..In conclusion, we detected two novel mutations in the MNX1 gene in cases with CS, which supports mutational analysis in the diagnosis of CS, even though the variability in the genotype and phenotype correlation maintains. ..
  42. Ericson Lindquist K, Johansson A, Leveen P, Elmberger G, Jonsson G, Staaf J, et al. Targeted sequencing may facilitate differential diagnostics of pulmonary tumours: a case series. Diagn Pathol. 2017;12:31 pubmed publisher
    ..Further studies on concordance and discordance of molecular genetic profiles between spatially or temporally different tumours with common origin may be helpful for improved diagnostics of pulmonary tumours. ..
  43. Fujino N, Kubo H, Maciewicz R. Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype. Lab Invest. 2017;97:1047-1062 pubmed publisher
    ..These results suggest that the Axl kinase signaling pathway is associated with the loss integrity of alveolar epithelium in pathological remodeling of human lung diseases. ..
  44. Cacci E, Villa A, Parmar M, Cavallaro M, Mandahl N, Lindvall O, et al. Generation of human cortical neurons from a new immortal fetal neural stem cell line. Exp Cell Res. 2007;313:588-601 pubmed
    ..Taking advantage of its clonality and homogeneity, this cell line will also be a valuable experimental tool to study the regulatory role of intrinsic and extrinsic factors in human NSC biology. ..
  45. Fava C, Montagnana M, Danese E, Sjogren M, Almgren P, Engstrom G, et al. Vanin-1 T26I polymorphism, hypertension and cardiovascular events in two large urban-based prospective studies in Swedes. Nutr Metab Cardiovasc Dis. 2013;23:53-60 pubmed publisher
    ..Our data do not support a major role for the VNN1 T26I variant in determining BP level and incident ischemic events. ..
  46. Fagerström Billai F, Wright A. Functional comparison of the Tup11 and Tup12 transcriptional corepressors in fission yeast. Mol Cell Biol. 2005;25:716-27 pubmed
    ..We conclude that Tup11 and Tup12 are at least partly functionally diverged and suggest that the Tup12 and Ssn6 proteins have adopted a specific role in regulation of the stress response. ..
  47. Beve J, Hu G, Myers L, Balciunas D, Werngren O, Hultenby K, et al. The structural and functional role of Med5 in the yeast Mediator tail module. J Biol Chem. 2005;280:41366-72 pubmed
    ..We discuss a possible role for Med5 in coordinating nuclear and mitochondrial gene transcription. ..
  48. Nookaew I, Gabrielsson B, Holmang A, Sandberg A, Nielsen J. Identifying molecular effects of diet through systems biology: influence of herring diet on sterol metabolism and protein turnover in mice. PLoS ONE. 2010;5:e12361 pubmed publisher
    ..This could be applied to improve diets for subjects exposed to health risks associated with obesity. ..
  49. Ekstrand J, Hellsten J, Wennström M, Tingström A. Differential inhibition of neurogenesis and angiogenesis by corticosterone in rats stimulated with electroconvulsive seizures. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1466-72 pubmed publisher
    ..Whether inhibition of angiogenesis affects other steps in the chain of events leading to the formation of fully integrated granule neurons remains to be elucidated. ..
  50. Ribbhammar U, Flornes L, Bäckdahl L, Luthman H, Fossum S, Lorentzen J. High resolution mapping of an arthritis susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes. Hum Mol Genet. 2003;12:2087-96 pubmed
    ..These candidate disease genes may be of general interest, given that rat 4q42, and the syntenic mouse 6F2 and human 12p13 regions are linked to several inflammatory diseases, including rheumatoid arthritis. ..
  51. Axelsson E, Lundqvist J, Sawicki A, Nilsson S, Schröder I, Al Karadaghi S, et al. Recessiveness and dominance in barley mutants deficient in Mg-chelatase subunit D, an AAA protein involved in chlorophyll biosynthesis. Plant Cell. 2006;18:3606-16 pubmed
    ..The cooperative behavior suggests that the D oligomer takes an active part in the conformational dynamics between the subunits of the enzyme. ..
  52. Minde J, Andersson T, Fulford M, Aguirre M, Nennesmo I, Remahl I, et al. A novel NGFB point mutation: a phenotype study of heterozygous patients. J Neurol Neurosurg Psychiatry. 2009;80:188-95 pubmed publisher
    ..The homozygous genotype gives disabling symptoms. The purpose of the present study was to evaluate the symptoms in heterozygous patients...
  53. Rekic D, Röshammar D, Mukonzo J, Ashton M. In silico prediction of efavirenz and rifampicin drug-drug interaction considering weight and CYP2B6 phenotype. Br J Clin Pharmacol. 2011;71:536-43 pubmed publisher
    ..Our findings, although based on a simulation approach using limited in vitro data, support the current recommendations for using a 50 kg bodyweight cut-off for efavirenz dose increment when co-treating with rifampicin. ..
  54. Castillejo Lopez C, Arias W, Baumgartner S. The fat-like gene of Drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs. J Biol Chem. 2004;279:24034-43 pubmed
    ..Based on our results, we propose a model where Ftl acts as a spacer to keep tubular epithelia apart rather than the previously described adhesive properties of the cadherin superfamily. ..
  55. Gendre D, Oh J, Boutté Y, Best J, Samuels L, Nilsson R, et al. Conserved Arabidopsis ECHIDNA protein mediates trans-Golgi-network trafficking and cell elongation. Proc Natl Acad Sci U S A. 2011;108:8048-53 pubmed publisher
    ..Hence, ECH is an evolutionarily conserved component of the TGN with a central role in TGN structure and function. ..
  56. Zetterberg H, Jansson A, Rymo L, Chen F, Karlsson A, Klein G, et al. The Epstein-Barr virus ZEBRA protein activates transcription from the early lytic F promoter by binding to a promoter-proximal AP-1-like site. J Gen Virol. 2002;83:2007-14 pubmed
  57. Wiman A, Floderus Y, Harper P. Novel mutations and phenotypic effect of the splice site modulator IVS3-48C in nine Swedish families with erythropoietic protoporphyria. J Hum Genet. 2003;48:70-6 pubmed
    ..Mild clinical and biochemical EPP signs may, however, be present in individuals carrying a T at position IVS3-48 in trans to a mutated allele, because this was the case in one of the individuals investigated in the present study. ..
  58. Pinto R, Gerber L, Eliasson M, Sundberg B, Trygg J. Strategy for minimizing between-study variation of large-scale phenotypic experiments using multivariate analysis. Anal Chem. 2012;84:8675-81 pubmed publisher
    ..Information from in-depth analysis of specific transgenic lines and independent peak identification validated our proposed strategy. ..
  59. Mottagui Tabar S, Faghihi M, Mizuno Y, Engström P, Lenhard B, Wasserman W, et al. Identification of functional SNPs in the 5-prime flanking sequences of human genes. BMC Genomics. 2005;6:18 pubmed
    ..Some SNPs behave differently in different cell types. ..
  60. Olsson M, Chester M. Polymorphism and recombination events at the ABO locus: a major challenge for genomic ABO blood grouping strategies. Transfus Med. 2001;11:295-313 pubmed
    ..The role of chi (chi) sequences is discussed. Finally, the various genotyping methods available are summarized and their advantages and limitations are analysed in the light of the increasing allelic variation. ..
  61. Edsbagge J, Johansson J, Esni F, Luo Y, Radice G, Semb H. Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development. 2005;132:1085-92 pubmed
    ..Thus, we propose a new model where blood vessel-derived sphingosine-1-phosphate stimulates growth and budding of the dorsal pancreatic endoderm by induction of mesenchymal cell proliferation. ..
  62. Isak G, Ryden Aulin M. Hypomodification of the wobble base in tRNAGlu, tRNALys, and tRNAGln suppresses the temperature-sensitive phenotype caused by mutant release factor 1. J Bacteriol. 2009;191:1604-9 pubmed publisher
    ..From genetic analyses we conclude that it is the lack of the 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) modification of the wobble base of tRNA(Glu), tRNA(Lys), and/or tRNA(Gln) that causes the suppressor phenotype. ..
  63. Otero J, Vongsangnak W, Asadollahi M, Olivares Hernandes R, Maury J, Farinelli L, et al. Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications. BMC Genomics. 2010;11:723 pubmed publisher
    ..The genome sequence, annotation, and a SNP viewer of CEN.PK113-7D are deposited at ..
  64. Flodby P, Barlow C, Kylefjord H, Ahrlund Richter L, Xanthopoulos K. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J Biol Chem. 1996;271:24753-60 pubmed
    ..These results suggest a critical role for C/EBPalpha in vivo for the acquisition of terminally differentiated functions in liver including the maintenance of physiologic energy homeostasis. ..
  65. Zettervall C, Anderl I, Williams M, Palmer R, Kurucz E, Ando I, et al. A directed screen for genes involved in Drosophila blood cell activation. Proc Natl Acad Sci U S A. 2004;101:14192-7 pubmed
    ..We conclude that the activation of a cellular response is complex and affected by multiple signaling pathways. ..
  66. Aase K, Ernkvist M, Ebarasi L, Jakobsson L, Majumdar A, Yi C, et al. Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Genes Dev. 2007;21:2055-68 pubmed
    ..Our data demonstrate a critical role for Amot during vascular patterning and endothelial polarization. ..
  67. Carlsson A, Wuttge D, Ingvarsson J, Bengtsson A, Sturfelt G, Borrebaeck C, et al. Serum protein profiling of systemic lupus erythematosus and systemic sclerosis using recombinant antibody microarrays. Mol Cell Proteomics. 2011;10:M110.005033 pubmed publisher
  68. Drowley L, Koonce C, Peel S, Jonebring A, Plowright A, Kattman S, et al. Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-β Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac Differentiation. Stem Cells Transl Med. 2016;5:164-74 pubmed publisher
    ..In addition, this assay system was able to identify novel and potent inducers of differentiation and proliferation of induced pluripotent stem cell-derived cardiac progenitor cells. ..
  69. Fridborg I, Kuusk S, Moritz T, Sundberg E. The Arabidopsis dwarf mutant shi exhibits reduced gibberellin responses conferred by overexpression of a new putative zinc finger protein. Plant Cell. 1999;11:1019-32 pubmed
    ..This suggests that SHI may act as a negative regulator of GA responses through transcriptional control...
  70. Holmberg K, Kuteeva E, Brumovsky P, Kahl U, Karlstrom H, Lucas G, et al. Generation and phenotypic characterization of a galanin overexpressing mouse. Neuroscience. 2005;133:59-77 pubmed
    ..These findings suggest that overexpressed galanin in some tissues of these mice can be released and via a receptor-mediated action influence pathophysiological processes. ..
  71. Kalbina I, Strid A. The role of NADPH oxidase and MAP kinase phosphatase in UV-B-dependent gene expression in Arabidopsis. Plant Cell Environ. 2006;29:1783-93 pubmed
    ..This suggests a complex dependency of the MAPK phosporylation level of the PR and PDF1.2 genes. Both NADPH oxidase mutants and the mkp1 mutant phenotypically responded to UV-B by growth retardation. ..
  72. Merilaita S, Ruxton G. Aposematic signals and the relationship between conspicuousness and distinctiveness. J Theor Biol. 2007;245:268-77 pubmed
    ..Thus, we suggest that description of aposematism as the teaming of a secondary defence with a conspicuous signal may be overly simplistic; we would rather that the signal were described as conspicuous and/or distinctive...
  73. Karim S, Alezzawi M, Garcia Petit C, Solymosi K, Khan N, Lindquist E, et al. A novel chloroplast localized Rab GTPase protein CPRabA5e is involved in stress, development, thylakoid biogenesis and vesicle transport in Arabidopsis. Plant Mol Biol. 2014;84:675-92 pubmed publisher
    ..The results observed suggest a role of CPRabA5e in transport to and from thylakoids, similar to cytosolic Rab proteins involved in vesicle transport...
  74. Tragante V, Barnes M, Ganesh S, Lanktree M, Guo W, Franceschini N, et al. Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet. 2014;94:349-60 pubmed publisher
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    ..Our finding on the first mutation in the human homologue of Drosophila rdgB indicates novel pathways and a potential important role of the PITPNM3 in mammalian phototransduction. ..
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    ..The coordination of luminal matrix secretion and endocytosis may be a general mechanism in tubular organ morphogenesis and maturation. ..
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    ..Subjects with the CT and TT genotypes, hitherto classified as lactase-persistent, differ in their physiological response to lactose intake, indicating differences in phenotype which could have clinical significance. ..
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