Experts and Doctors on phenotype in Japan


Locale: Japan
Topic: phenotype

Top Publications

  1. Uemura H, Jigami Y. Role of GCR2 in transcriptional activation of yeast glycolytic genes. Mol Cell Biol. 1992;12:3834-42 pubmed
    ..Furthermore, a Rap1/Gcr2 fusion protein partially complemented the defects of gcr1 strains. These results suggest that Gcr2 has transcriptional activation activity and that the GCR1 and GCR2 gene products function together. ..
  2. Miura T, Nakamura R, Horii E, Sano H. Three cases of syndactyly, polydactyly, and hypoplastic triphalangeal thumb: (Haas's malformation). J Hand Surg Am. 1990;15:445-9 pubmed
    ..In all instances the supernumerary digit had a triphalangeal configuration and the thenar muscles were hypoplastic, often associated with some degree of webbing. ..
  3. Takeda T, Imai Y, Yamamoto M. Substitution at position 116 of Schizosaccharomyces pombe calmodulin decreases its stability under nitrogen starvation and results in a sporulation-deficient phenotype. Proc Natl Acad Sci U S A. 1989;86:9737-41 pubmed
    ..Two other mutations at position 116 resulted in similar but leakier Spo- phenotypes. ..
  4. Matsuo I, Kuratani S, Kimura C, Takeda N, Aizawa S. Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev. 1995;9:2646-58 pubmed
    ..The evolutionary significance of Otx2 mutant phenotypes was discussed for the innovation of the neurocranium and the jaw. ..
  5. Okamoto N, Wada Y, Ida S, Koga R, Ozono K, Chiyo H, et al. Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype. Hum Mol Genet. 1994;3:1565-8 pubmed
    ..The phenotypic expression of PIT1 abnormality may depend on different transcription of the PIT1 gene. ..
  6. Tateishi T, Chida M, Ariyoshi N, Mizorogi Y, Kamataki T, Kobayashi S. Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population. Clin Pharmacol Ther. 1999;65:570-5 pubmed
    ..Individuals homozygous for *10 who have relatively low in vivo CYP2D6 activity represent almost 20% of the Japanese population. In addition, we did not identify any subjects with amplified *2 among our 98 Japanese men. ..
  7. Sugihara T, Kaul S, Kato J, Reddel R, Nomura H, Wadhwa R. Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway. J Biol Chem. 2001;276:18649-52 pubmed
    ..The data demonstrated a novel mechanism of down-regulation of the p19ARF-p53 pathway. ..
  8. Tokairin T, Nishikawa Y, Doi Y, Watanabe H, Yoshioka T, Su M, et al. A highly specific isolation of rat sinusoidal endothelial cells by the immunomagnetic bead method using SE-1 monoclonal antibody. J Hepatol. 2002;36:725-33 pubmed
    ..Our simple and specific isolation method enables us to culture SEC with high purity and should be useful for the biological analysis of SEC. ..
  9. Shimokawa I, Higami Y, Utsuyama M, Tuchiya T, Komatsu T, Chiba T, et al. Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model. Am J Pathol. 2002;160:2259-65 pubmed
    ..The results of the present study support the hypothesis, but suggest that there is an optimal level of the GH-IGF-1 axis to maximize survival in mammals. ..

More Information

Publications293 found, 100 shown here

  1. Kogawa K, Kudoh J, Nagafuchi S, Ohga S, Katsuta H, Ishibashi H, et al. Distinct clinical phenotype and immunoreactivity in Japanese siblings with autoimmune polyglandular syndrome type 1 (APS-1) associated with compound heterozygous novel AIRE gene mutations. Clin Immunol. 2002;103:277-83 pubmed
    ..The same AIRE gene mutations can thus be associated with characteristic and noncharacteristic phenotypes of APS-1, and HLA may possibly influence the phenotype of APS-1...
  2. Tsuzuki S, Sekiguchi S, Kamimura M, Kiuchi M, Hayakawa Y. A cytokine secreted from the suboesophageal body is essential for morphogenesis of the insect head. Mech Dev. 2005;122:189-97 pubmed
    ..The cytokine-induced fusion of bilateral procephalic lobes is thought to be evolutionarily conserved at least in insects, because of the widespread occurrence of the suboesophageal body in insect embryos. ..
  3. Kiba A, Sangawa Y, Ohnishi K, Yao N, Park P, Nakayashiki H, et al. Induction of apoptotic cell death leads to the development of bacterial rot caused by Pseudomonas cichorii. Mol Plant Microbe Interact. 2006;19:112-22 pubmed
    ..These results suggest that apoptotic cell death might be closely associated with the development of bacterial rot caused by P. cichorii. ..
  4. Kamiishi T, Itoh Y, Meguro A, Nishida T, Sasaki S, Nanba K, et al. [Four-digit allele genotyping of HLA-A and HLA-B genes in Japanese patients with Behçet's disease (BD) by a PCR-SSOP-luminex method and stratification analysis according to each major symptom of BD]. Nippon Ganka Gakkai Zasshi. 2008;112:451-8 pubmed
    ..The significant increase of HLA-A* 26 in the BD patients without HLA-B*51 suggests that this allele itself might be one of the primary susceptibility genes involved in the development of BD independently of HLA-B*51. ..
  5. Suto J. Metabolic consequence of congenital asplenia caused by the Dominant hemimelia mutation in mice. J Vet Med Sci. 2009;71:177-82 pubmed
    ..The present study shows that Dh has effects on lipid metabolism. Although Dh has multiple phenotypic effects it is possible that the change in lipid levels is affected in part by the absence of the spleen. ..
  6. Tsuwamoto R, Yokoi S, Takahata Y. Arabidopsis EMBRYOMAKER encoding an AP2 domain transcription factor plays a key role in developmental change from vegetative to embryonic phase. Plant Mol Biol. 2010;73:481-92 pubmed publisher
  7. Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, et al. PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. PLoS ONE. 2011;6:e18324 pubmed publisher
    ..These results suggested that PDK1 and Foxo1 signaling pathways play important roles in the control of energy homeostasis through AGRP-independent mechanisms. ..
  8. Yamazaki K, Wakasugi N, Tomita T, Kikuchi T, Mukoyama M, Ando K. Gracile axonal dystrophy (GAD), a new neurological mutant in the mouse. Proc Soc Exp Biol Med. 1988;187:209-15 pubmed
    ..The mutation is inherited as an autosomal recessive trait. It was, therefore, named gracile axonal dystrophy (GAD) with the gene symbol gad. The mice could be a new pathological model for the study of neuroaxonal dystrophy. ..
  9. Fujiwara H, Kikutani H, Suematsu S, Naka T, Yoshida K, Tanaka T, et al. The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci U S A. 1994;91:6835-9 pubmed
    ..Germinal center formation after immunization and in vitro proliferative response of B cells were not affected in mutant mice. However, antigen-specific IgE-mediated enhancement of antibody responses was severely impaired. ..
  10. Akiyama Y, Ogura T, Ito K. Involvement of FtsH in protein assembly into and through the membrane. I. Mutations that reduce retention efficiency of a cytoplasmic reporter. J Biol Chem. 1994;269:5218-24 pubmed
    ..These results suggest that FtsH participates in assembly of proteins into and through the membrane. It is needed for the cell to assure efficient stop-transfer of some transmembrane proteins. ..
  11. Uemura T, Oda H, Kraut R, Hayashi S, Kotaoka Y, Takeichi M. Zygotic Drosophila E-cadherin expression is required for processes of dynamic epithelial cell rearrangement in the Drosophila embryo. Genes Dev. 1996;10:659-71 pubmed
  12. Kawamura M, Kominami K, Takeuchi J, Toh e A. A multicopy suppressor of nin1-1 of the yeast Saccharomyces cerevisiae is a counterpart of the Drosophila melanogaster diphenol oxidase A2 gene, Dox-A2. Mol Gen Genet. 1996;251:146-52 pubmed
    ..This morphology is similar to that of nin1-1 cells kept at a restrictive temperature. These results suggest that SUN2 is a functional counterpart of Dox-A2 and that these genes play a pivotal role in the cell cycle in each organism. ..
  13. Ishikawa T, Kibe T, Wada Y. Deletion of small nuclear ribonucleoprotein polypeptide N (SNRPN) in Prader-Willi syndrome detected by fluorescence in situ hybridization: two sibs with the typical phenotype without a cytogenetic deletion in chromosome 15q. Am J Med Genet. 1996;62:350-2 pubmed
    ..This implies a smaller deletion limited to the PWS critical region. FISH with a SNRPN probe will permit analysis of PWS patients with limited deletions not detectable with other probes. ..
  14. An H, Mogami K. Isolation of 88F actin mutants of Drosophila melanogaster and possible alterations in the mutant actin structures. J Mol Biol. 1996;260:492-505 pubmed
    ..On the basis of these phenotypes and the known atomic structure of actin, possible alterations in the structure of actin brought about by these mutations are discussed. ..
  15. Obata H, Hayashi K, Nishida W, Momiyama T, Uchida A, Ochi T, et al. Smooth muscle cell phenotype-dependent transcriptional regulation of the alpha1 integrin gene. J Biol Chem. 1997;272:26643-51 pubmed
    ..These results indicate that alpha1 integrin expression in smooth muscle cells is regulated transcriptionally in a phenotype-dependent manner and that serum response factor binding plays a crucial role in this regulation. ..
  16. Sudo K, Maekawa M, Akizuki S, Magara T, Ogasawara H, Tanaka T. Human butyrylcholinesterase L330I mutation belongs to a fluoride-resistant gene, by expression in human fetal kidney cells. Biochem Biophys Res Commun. 1997;240:372-5 pubmed
    ..These results showed this amino acid substitution of BCHE, Leu330 to Ile, really caused the abnormal DN and FN. We conclude that the BCHE L330I mutation is a fluoride-resistant gene, a Japanese type fluoride-resistant gene...
  17. Motegi F, Nakano K, Kitayama C, Yamamoto M, Mabuchi I. Identification of Myo3, a second type-II myosin heavy chain in the fission yeast Schizosaccharomyces pombe. FEBS Lett. 1997;420:161-6 pubmed
    ..Moreover, the function of Myo2 can be replaced by overexpressed Myo3. We observed a modest synthetic interaction between Myo2 and Myo3. Thus, Myo2 and Myo3 seem to cooperate in the formation of the F-actin ring in S. pombe. ..
  18. Yasukochi Y, Kanda T, Tamura T. Cloning of two Bombyx homologues of the Drosophila rosy gene and their relationship to larval translucent skin colour mutants. Genet Res. 1998;71:11-9 pubmed
    ..In addition, a length polymorphism of the second intron of the BmXDH1 co-segregated with the oq translucent phenotype, suggesting that deficiency in BmXDH1 is the cause of the oq translucent phenotype...
  19. Koarada S, Tada Y, Ushiyama O, Morito F, Suzuki N, Ohta A, et al. B cells lacking RP105, a novel B cell antigen, in systemic lupus erythematosus. Arthritis Rheum. 1999;42:2593-600 pubmed
    ..These findings suggest that loss of RP105 is associated with B cell activation and increased disease activity in SLE patients. ..
  20. Fujita Y, Takegawa K. Characterization of two genes encoding putative cysteine synthase required for cysteine biosynthesis in Schizosaccharomyces pombe. Biosci Biotechnol Biochem. 2004;68:306-11 pubmed
    ..pombe cells. We constructed a bacterial-S. pombe shuttle vector containing cys1a+ as a selective marker gene. The combination of the cysteine auxotroph and new vector could be useful for the expression of a heterologous protein. ..
  21. Wang Y, Yamazoe A, Suzuki S, Liu C, Aono T, Oyaizu H. Isolation and characterization of dibenzofuran-degrading Comamonas sp. strains isolated from white clover roots. Curr Microbiol. 2004;49:288-94 pubmed
    ..They are the first reported Comamonas sp. strains capable of utilizing DF as a sole carbon source. This provides additional information on the diversity of DF-degrading bacteria...
  22. Nakase Y, Fukuda K, Chikashige Y, Tsutsumi C, Morita D, Kawamoto S, et al. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Genetics. 2006;173:569-78 pubmed
    ..On the basis of these results, we discuss TSC pathology and possible improvement in chemotherapy for TSC. ..
  23. Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Hikita A, Mitomi H, et al. Regional differences in chondrocyte metabolism in osteoarthritis: a detailed analysis by laser capture microdissection. Arthritis Rheum. 2008;58:154-63 pubmed publisher
    ..The change of gene expression profile was most obvious in the upper region of the degenerated cartilage. The altered gene expression at that region may be responsible for the loss of cartilage matrix associated with OA. ..
  24. Takahata Y, Hinoi E, Takarada T, Nakamura Y, Ogawa S, Yoneda Y. Positive regulation by ?-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4. J Biol Chem. 2012;287:33293-303 pubmed
    ..These results suggest that GABA(B)R1 positively regulates chondrogenesis through a mechanism relevant to the acceleration of nuclear translocation of ATF4 for Ihh expression in chondrocytes...
  25. Kamimoto Y, Terasaka K, Hamamoto M, Takanashi K, Fukuda S, Shitan N, et al. Arabidopsis ABCB21 is a facultative auxin importer/exporter regulated by cytoplasmic auxin concentration. Plant Cell Physiol. 2012;53:2090-100 pubmed publisher
    ..These findings suggest that ABCB21 functions as a facultative importer/exporter controlling auxin concentrations in plant cells...
  26. Miura T, Nakamura R, Horii E. Congenital hand anomalies in Japan: a family study. J Hand Surg Am. 1990;15:439-44 pubmed
    ..None of the relatives had ulnar deficiency or symbrachydactyly. ..
  27. Akiyama Y, Ito K. A new Escherichia coli gene, fdrA, identified by suppression analysis of dominant negative FtsH mutations. Mol Gen Genet. 1995;249:202-8 pubmed
    ..The intact fdrA gene (11.9 min on the chromosome) directed the synthesis of a 60 kDa protein in vitro. ..
  28. Yamanaka K, Ogura T, Murata K, Suzaki T, Niki H, Hiraga S. Characterization of translucent segments observed in an smbA mutant of Escherichia coli. FEMS Microbiol Lett. 1994;116:61-6 pubmed
    ..Electron microscopic observation revealed that the translucent segments resulted from the enlargement of a periplasmic space by separation of the inner membrane from the peptidoglycan layer and the outer membrane. ..
  29. Mac S om in R, Nakata N, Murai T, Yoshikawa M, Tsuji H, Sasakawa C. Identification and characterization of ispA, a Shigella flexneri chromosomal gene essential for normal in vivo cell division and intracellular spreading. Mol Microbiol. 1996;19:599-609 pubmed
    ..These results thus show that ispA is an essential virulence gene affecting several functions of the virulence process...
  30. Ogasawara K, Yabe R, Uchikawa M, Saitou N, Bannai M, Nakata K, et al. Molecular genetic analysis of variant phenotypes of the ABO blood group system. Blood. 1996;88:2732-7 pubmed
    ..Our data indicate that different alleles could cause the same ABO variant phenotypes, and that these alleles do not necessarily belong to a single evolutionary lineage. ..
  31. Kitamura K, Yamashita I. Identification of a novel casein kinase-1 homolog in fission yeast Schizosaccharomyces pombe. Gene. 1998;214:131-7 pubmed
    ..Thus, S. pombe has three highly related CK1 isoforms (Cki1, Cki2 and Cki3), but none of them has an essential function. ..
  32. Miyahara K, Hirata D, Miyakawa T. Functional interaction of Isr1, a predicted protein kinase, with the Pkc1 pathway in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 1998;62:1376-80 pubmed
    ..These results suggest that Isr1 functions in an event important for growth in a manner redundant with a Mpk1-independent branch of the Pkc1 signalling pathways. ..
  33. Yamaoka T, Yoshino K, Yamada T, Idehara C, Hoque M, Moritani M, et al. Diabetes and tumor formation in transgenic mice expressing Reg I. Biochem Biophys Res Commun. 2000;278:368-76 pubmed
    ..Moreover, the tumor-promoting activity of Reg I protein should be considered for its possible clinical applications. ..
  34. Inaoka T, Kasai K, Ochi K. Construction of an in vivo nonsense readthrough assay system and functional analysis of ribosomal proteins S12, S4, and S5 in Bacillus subtilis. J Bacteriol. 2001;183:4958-63 pubmed
    ..subtilis. The efficacy of our in vivo nonsense readthrough assay system was demonstrated in our investigation of the function of ribosomal proteins and translational factors. ..
  35. Inaba N, Hiruma T, Togayachi A, Iwasaki H, Wang X, Furukawa Y, et al. A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression. Blood. 2003;101:2870-6 pubmed
    ..These findings indicate that the expression of the blood group I antigen in erythrocytes is determined by a novel IGnT3, not by IGnT1 or IGnT2. ..
  36. Yanagida F, Chen Y, Shinohara T. Isolation and characterization of lactic acid bacteria from soils in vineyards. J Gen Appl Microbiol. 2005;51:313-8 pubmed
  37. Kanie S, Horibata K, Kawano M, Isogawa A, Sakai A, Matsuo N, et al. Roles of RecA protein in spontaneous mutagenesis in Escherichia coli. Genes Genet Syst. 2007;82:99-108 pubmed
    ..Thus, it seems likely that the single-base frameshifts are derived from slippage errors that are not directly caused by DNA lesions but made indirectly during some kind of error-prone DNA synthesis in the recA mutant cells. ..
  38. Tsubokawa T, Yagi K, Nakanishi C, Zuka M, Nohara A, Ino H, et al. Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia. Am J Physiol Heart Circ Physiol. 2010;298:H1320-9 pubmed publisher
  39. Nakamura M, Toyota M, Tasaka M, Morita M. An Arabidopsis E3 ligase, SHOOT GRAVITROPISM9, modulates the interaction between statoliths and F-actin in gravity sensing. Plant Cell. 2011;23:1830-48 pubmed publisher
    ..SGR9 may promote detachment of amyloplasts from AFs, allowing the amyloplasts to sediment in the AFs-dependent equilibrium of amyloplast dynamics. ..
  40. Imanishi H, Hattori K, Wada R, Ishikawa K, Fukuda S, Takenaga K, et al. Mitochondrial DNA mutations regulate metastasis of human breast cancer cells. PLoS ONE. 2011;6:e23401 pubmed publisher
    ..Thus, human tumor cells possess an mtDNA-mediated metastatic pathway that is required for expression of the highly metastatic potential in the absence of ROS production. ..
  41. Takai T, Adachi S, Taguchi Shiobara F, Sanoh Arai Y, Iwasawa N, Yoshinaga S, et al. A natural variant of NAL1, selected in high-yield rice breeding programs, pleiotropically increases photosynthesis rate. Sci Rep. 2013;3:2149 pubmed publisher
    ..The identification and utilization of NAL1 (GPS) can enhance future high-yield breeding and provides a new strategy for increasing rice productivity. ..
  42. Watanabe M, Nakano K, Matsunari H, Matsuda T, Maehara M, Kanai T, et al. Generation of interleukin-2 receptor gamma gene knockout pigs from somatic cells genetically modified by zinc finger nuclease-encoding mRNA. PLoS ONE. 2013;8:e76478 pubmed publisher
    ..Our findings demonstrate that the combination of ZFN-encoding mRNAs and SCNT provides a simple robust method for producing KO pigs without genomic integration. ..
  43. Kato T, Kawahito H, Kishida S, Irie D, Wakana N, Kikai M, et al. Bone marrow angiotensin AT2 receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions. J Renin Angiotensin Aldosterone Syst. 2015;16:936-46 pubmed publisher
    ..Our findings demonstrate that BM-AT2 deficiency aggravates atherosclerosis, at least in part, by eliminating the anti-atherogenic properties of macrophages elicited by LXRβ activation. ..
  44. Sasaki N, Konagaya T, Watanabe M, Rutowski R. Indicators of recent mating success in the pipevine swallowtail butterfly (Battus philenor) and their relationship to male phenotype. J Insect Physiol. 2015;83:30-6 pubmed publisher
    ..In addition, the color of the dorsal hindwing, a feature that females use in mate choice, was significantly greener in males, that according to our criteria, had recently-mated than in males that had not. ..
  45. Ohtani N. [The role of SASP in tumor microenvironment.]. Clin Calcium. 2017;27:835-843 pubmed publisher
  46. Nakamura Y, Hattori N, Iida N, Yamashita S, Mori A, Kimura K, et al. Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway. Cancer Lett. 2017;402:100-109 pubmed publisher
    ..Thus, this study indicates the therapeutic potential of targeting of super-enhancers and mutant BRAF in patients with BRAFV600E-mutant colorectal cancer. ..
  47. Nagasawa S, Tokishita S, Aiba H, Mizuno T. A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli. Mol Microbiol. 1992;6:799-807 pubmed
    ..coli genetic map. The BarA protein in isolated membranes was demonstrated in vitro to undergo phosphorylation in the presence of ATP. ..
  48. Sawai S, Shimono A, Hanaoka K, Kondoh H. Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes. New Biol. 1991;3:861-9 pubmed
    ..N-myc-null ES cells offer a valuable tool in chimera analysis to elucidate the requirement for N-myc function in embryogenesis. ..
  49. Ueno K, Saha A, Satoh T, Kitagawa H. Effects of heptaminol AMP amidate on T cell populations of peripheral blood lymphocytes and splenocytes in mice. Res Commun Chem Pathol Pharmacol. 1991;71:125-8 pubmed
    ..The T cell surface phenotypes Thy1.2, Lyt1, L3T4 and Lyt2 increased on the PBL of HAA administered mice to 136, 145, 144 and 153%, respectively over those on the PBL of control mice...
  50. Matsuda T, Tonomura H, Baba A, Iwata H. Difference in thiamine metabolism between extensor digitorum longus and soleus muscles. Comp Biochem Physiol B. 1989;94:399-403 pubmed
    ..4. Tenotomy had little effect on thiamine phosphate levels and the thiamine-related enzyme activities in rat skeletal muscles. ..
  51. Nobukuni Y, Mitsubuchi H, Hayashida Y, Ohta K, Indo Y, Ichiba Y, et al. Heterogeneity of mutations in maple syrup urine disease (MSUD): screening and identification of affected E1 alpha and E1 beta subunits of the branched-chain alpha-keto-acid dehydrogenase multienzyme complex. Biochim Biophys Acta. 1993;1225:64-70 pubmed
    ..Indo, Y., Endo, F., Yoshioka, A. and Matsuda, I. (1991) J. Clin. Invest. 87, 1862-1866)) were novel mutations. The sites of amino-acid substitution were all conserved in other species. Thus, mutations causing MSUD are heterogenous. ..
  52. Takeda T, Hosokawa M, Higuchi K. Senescence-accelerated mouse (SAM): a novel murine model of senescence. Exp Gerontol. 1997;32:105-9 pubmed
    ..The genetic background and significance of SAM development are discussed...
  53. Kawamata T, Akiguchi I, Yagi H, Irino M, Sugiyama H, Akiyama H, et al. Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory. Exp Gerontol. 1997;32:161-9 pubmed
    ..Here we review the changes seen in both neuronal or glial components in SAMP8/P10 brains. They may serve as markers of the neuronal degeneration leading to the deficits in learning and memory. ..
  54. Oda H, Uemura T, Takeichi M. Phenotypic analysis of null mutants for DE-cadherin and Armadillo in Drosophila ovaries reveals distinct aspects of their functions in cell adhesion and cytoskeletal organization. Genes Cells. 1997;2:29-40 pubmed
    ..We therefore propose that the molecular complex of DE-cadherin and Armadillo which is present in normal cells is endowed with multiple functions derived from each molecule. ..
  55. Hakuno F, Hughes D, Yamamoto M. The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity. Genes Cells. 1996;1:303-15 pubmed
    ..Mra1 is unlikely to interact directly with the known pathways downstream of Ras1, implying that it may be a factor constituting a third pathway regulated by Ras1. ..
  56. Tobe T, Tatsuno I, Katayama E, Wu C, Schoolnik G, Sasakawa C. A novel chromosomal locus of enteropathogenic Escherichia coli (EPEC), which encodes a bfpT-regulated chaperone-like protein, TrcA, involved in microcolony formation by EPEC. Mol Microbiol. 1999;33:741-52 pubmed
    ..The 90 kDa protein was revealed to be intimin, a protein product of the eae gene, which is required for the EPEC attaching/effacing phenotype, suggesting a direct interaction of TrcA with intimin in the cytoplasmic compartment. ..
  57. Makise M, Sakamoto K, Tsuchiya T, Mizushima T. Identification of a high-copy-number plasmid suppressor of a lethal phenotype caused by mutant DnaA protein which has decreased intrinsic ATPase activity. Biol Pharm Bull. 1999;22:904-9 pubmed
    ..The mechanisms by which these genes suppressed the lethal phenotype were examined in vivo and in vitro. ..
  58. Ohira Y, Yoshinaga T, Ohara M, Nonaka I, Yoshioka T, Yamashita Goto K, et al. Myonuclear domain and myosin phenotype in human soleus after bed rest with or without loading. J Appl Physiol (1985). 1999;87:1776-85 pubmed
    ..The specific adaptive cellular strategies involved may be a function of the duration and magnitude of the adaptive stimulus as well as the immediate activity history of the fiber before the newly changed functional demands...
  59. Takada I, Yu R, Xu H, Lambert M, Montana V, Kliewer S, et al. Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype. Mol Endocrinol. 2000;14:733-40 pubmed
  60. Sugimura I, Adachi Yamada T, Nishi Y, Nishida Y. A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development. Dev Growth Differ. 2000;42:237-48 pubmed
    ..Dwhn is the first invertebrate Whn-like transcriptional regulator, and should provide insights into the basic functions and evolution of the whn family genes. ..
  61. Tsuruga E, Irie K, Sakakura Y, Yajima T. Tropoelastin expression by periodontal fibroblasts. J Dent Res. 2002;81:198-202 pubmed
    ..These results suggest that the different tropoelastin expression patterns reflect the difference between HGF and HPLF phenotypes. ..
  62. Aoyama M, Shidoji Y, Saimei M, Tsunawake N, Ichinose M. Phenotypic linkage between single-nucleotide polymorphisms of beta3-adrenergic receptor gene and NADH dehydrogenase subunit-2 gene, with special reference to eating behavior. Biochem Biophys Res Commun. 2003;309:261-5 pubmed
    ..A combination of SNPs of the nuclear BAR-3 and the mitochondrial ND2 genes may affect eating behavior besides the biochemical and metabolic process of signal transduction and electron transfer system. ..
  63. Ohnishi J, Ohnishi E, Shibuya H, Takahashi T. Functions for proteinases in the ovulatory process. Biochim Biophys Acta. 2005;1751:95-109 pubmed
    ..Consistently, the genetic deletion of each individual gene in mice shows their functional overlap in the reproductive activity. ..
  64. Yamaguchi T, Lee D, Miyao A, Hirochika H, An G, Hirano H. Functional diversification of the two C-class MADS box genes OSMADS3 and OSMADS58 in Oryza sativa. Plant Cell. 2006;18:15-28 pubmed publisher
    ..e., the functions regulated by AG have been partially partitioned into two paralogous genes, OSMADS3 and OSMADS58, which were produced by a recent gene duplication event in plant evolution)...
  65. Iuchi S, Suzuki H, Kim Y, Iuchi A, Kuromori T, Ueguchi Tanaka M, et al. Multiple loss-of-function of Arabidopsis gibberellin receptor AtGID1s completely shuts down a gibberellin signal. Plant J. 2007;50:958-66 pubmed
    ..These results show that all AtGID1s function as GA receptors in Arabidopsis, but have specific role(s) for growth and development. ..
  66. Hiraga J, Tomita A, Sugimoto T, Shimada K, Ito M, Nakamura S, et al. Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance. Blood. 2009;113:4885-93 pubmed publisher
    ..These findings suggest that some epigenetic mechanisms may be partly related to the down-regulation of CD20 expression after rituximab treatment. ..
  67. Sugai T, Tsukahara M, Endoh M, Shioi Y, Takebe N, Mue Y, et al. Analysis of cell cycle-related proteins in gastric intramucosal differentiated-type cancers based on mucin phenotypes: a novel hypothesis of early gastric carcinogenesis based on mucin phenotype. BMC Gastroenterol. 2010;10:55 pubmed publisher
    ..Our results suggest that the levels of some cell cycle regulators appear to be associated with mucin phenotypes of early gastric differentiated-type cancers. ..
  68. Matsubara K, Yamanouchi U, Nonoue Y, Sugimoto K, Wang Z, Minobe Y, et al. Ehd3, encoding a plant homeodomain finger-containing protein, is a critical promoter of rice flowering. Plant J. 2011;66:603-12 pubmed publisher
    ..Our results demonstrate that the PHD-finger gene Ehd3 acts as a promoter in the unique genetic pathway responsible for photoperiodic flowering in rice. ..
  69. Sato Y, Nagata S, Takiguchi M. Effective elicitation of human effector CD8+ T Cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1. PLoS ONE. 2012;7:e42776 pubmed publisher
    ..These results suggest that hNOK/B51Tg mice had CD8(+) T cells that were capable of differentiating into effector T cells after viral antigen stimulation and had a greater ability to elicit effector CD8(+) T cells than hNOK ones. ..
  70. Lessard S, Gatof E, Beaudoin M, Schupp P, Sher F, Ali A, et al. An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility. J Clin Invest. 2017;127:3065-3074 pubmed publisher
    ..Our study supports ATP2B4 as a potential target for modulating rbc hydration in erythroid disorders and malaria infection. ..
  71. Okano H, Hayashi S, Tanimura T, Sawamoto K, Yoshikawa S, Watanabe J, et al. Regulation of Drosophila neural development by a putative secreted protein. Differentiation. 1992;52:1-11 pubmed
  72. Nakahigashi K, Nishimura K, Miyamoto K, Inokuchi H. Photosensitivity of a protoporphyrin-accumulating, light-sensitive mutant (visA) of Escherichia coli K-12. Proc Natl Acad Sci U S A. 1991;88:10520-4 pubmed
    ..When cells are illuminated with visible light, protoporphyrin IX seems to produce an active species of oxygen (probably 1O2) that is harmful to the cells. This defect is the same as that associated with the human disease protoporphyria. ..
  73. Yabu K. Salt-induced L-forms of Staphylococcus aureus. Microbiol Immunol. 1995;39:425-7 pubmed
    ..Incubation of growing cultures with lipoteichoic acid, sodium polyanethole sulfonate and subtilisin resulted in inhibition of L-form induction. ..
  74. Saleh A, Yamanaka K, Niki H, Ogura T, Yamazoe M, Hiraga S. Carboxyl terminal region of the MukB protein in Escherichia coli is essential for DNA binding activity. FEMS Microbiol Lett. 1996;143:211-6 pubmed
    ..This mutant MukB protein was defective for DNA binding, while the ATP binding activity remained unaffected. A truncated MukB protein that is short of 109 amino acids from the C-terminus failed to bind DNA. ..
  75. Takiyama N, Itoh K, Shimmoto M, Nishimoto J, Inui K, Sakuraba H, et al. Molecular form and subcellular distribution of acid beta-galactosidase in fibroblasts from patients with GM1 gangliosidosis, Morquio B disease and galactosialidosis. Brain Dev. 1997;19:126-30 pubmed
    ..The combined use of immunoprecipitation and immunostaining was useful for analysing the pathophysiology of the intracellular processing and transport of the mutant beta-galactosidase. ..
  76. Iwahashi H, Nwaka S, Obuchi K, Komatsu Y. Evidence for the interplay between trehalose metabolism and Hsp104 in yeast. Appl Environ Microbiol. 1998;64:4614-7 pubmed
    ..These results suggest that during heat shock, Hsp104 contributes to the simultaneous increase in both accumulation and degradation of trehalose. ..
  77. Abe K, Yamamura K, Suzuki M. Molecular and embryological characterization of a new transgene-induced null allele of mouse Brachyury locus. Mamm Genome. 2000;11:238-40 pubmed
  78. Takata M, Sasaki M, Sonoda E, Fukushima T, Morrison C, Albala J, et al. The Rad51 paralog Rad51B promotes homologous recombinational repair. Mol Cell Biol. 2000;20:6476-82 pubmed
    ..These findings show that Rad51B is important for repairing various types of DNA lesions and maintaining chromosome integrity. ..
  79. Nakano H, Kawashima M, Okada S, Igarashi T, Nakata M, Ogino M. Effectiveness of laparoscopic gonadectomy using abdominal wall lift method on Turner's syndrome patients with 45, X/46, XY mosaicism. J Laparoendosc Adv Surg Tech A. 2001;11:101-4 pubmed
    ..Laparoscopy using the abdominal wall lift method has an advantage over CO2 pneumoperitoneum method for patients with Turner's syndrome when it is difficult to intubate because of a webbed neck or a shortened trachea. ..
  80. Nakano H, Goto S, Nakayashiki T, Inokuchi H. Temperature-sensitive mutations in various genes of Escherichia coli K12 can be suppressed by the ssrA gene for 10Sa RNA (tmRNA). Mol Genet Genomics. 2001;265:615-21 pubmed
    ..Considering the fact that ssrA-suppressible mutants could be isolated as temperature-sensitive mutants with mutations in different genes, it seems evident that trans-translation can occur on mRNA that is not lacking its stop codon. ..
  81. Poirier C, Yoshiki A, Fujiwara K, Guenet J, Kusakabe M. Hague (Hag). A new mouse hair mutation with an unstable semidominant allele. Genetics. 2002;162:831-40 pubmed
    ..Fourteen genes were mapped to this region; of these, 11 were expressed in the skin (5 epidermic cytokeratin and 6 hard keratin genes), but none were mutated in hague mice. ..
  82. Kanatsu Shinohara M, Ogonuki N, Inoue K, Miki H, Ogura A, Toyokuni S, et al. Long-term proliferation in culture and germline transmission of mouse male germline stem cells. Biol Reprod. 2003;69:612-6 pubmed
    ..Long-term spermatogonial stem cell culture will be useful for studying spermatogenesis mechanism and has important implications for developing new technology in transgenesis or medicine...
  83. Yano D, Sato M, Saito C, Sato M, Morita M, Tasaka M. A SNARE complex containing SGR3/AtVAM3 and ZIG/VTI11 in gravity-sensing cells is important for Arabidopsis shoot gravitropism. Proc Natl Acad Sci U S A. 2003;100:8589-94 pubmed
    ..These results suggest that vesicle transport to the prevacuolar compartment/vacuole in the endodermal cells, mediated by a specific SNARE complex containing AtVAM3 and AtVTI11, plays an important role in shoot gravitropism. ..
  84. Hinata N, Takemura T, Ikushima S, Yanagawa T, Ando T, Okada J, et al. Phenotype of regenerative epithelium in idiopathic interstitial pneumonias. J Med Dent Sci. 2003;50:213-24 pubmed
    ..The different origin of regenerative epithelium may reflect the severity and extent of the injury and the degree of consequent fibrosis in UIP and NSIP. ..
  85. Ahmed A, Miyoshi S, Shinoda S, Shimamoto T. Molecular characterization of a multidrug-resistant strain of enteroinvasive Escherichia coli O164 isolated in Japan. J Med Microbiol. 2005;54:273-8 pubmed
  86. Katagiri T, Ishiyama K, Kato T, Tabata S, Kobayashi M, Shinozaki K. An important role of phosphatidic acid in ABA signaling during germination in Arabidopsis thaliana. Plant J. 2005;43:107-17 pubmed
    ..These results suggest that PA is involved in ABA signaling and that AtLPP2 functions as a negative regulator upstream of ABI4, which encodes an AP2-type transcription factor, in ABA signaling during germination. ..
  87. Kapoor M, Baba A, Kubo K, Shibuya K, Matsui K, Tanaka Y, et al. Transgene-triggered, epigenetically regulated ectopic expression of a flower homeotic gene pMADS3 in Petunia. Plant J. 2005;43:649-61 pubmed
    ..We speculate on possible molecular mechanisms underlying these epigenetic phenomena. ..
  88. Takeo S, Tsuda M, Akahori S, Matsuo T, Aigaki T. The calcineurin regulator sra plays an essential role in female meiosis in Drosophila. Curr Biol. 2006;16:1435-40 pubmed
    ..To our knowledge, this is the first unambiguous demonstration that the regulation of calcineurin signaling by MCIPs plays a critical role in a defined biological process. ..
  89. Kaneko A, Umeyama T, Utena Abe Y, Yamagoe S, Niimi M, Uehara Y. Tcc1p, a novel protein containing the tetratricopeptide repeat motif, interacts with Tup1p to regulate morphological transition and virulence in Candida albicans. Eukaryot Cell. 2006;5:1894-905 pubmed publisher
    ..Consistent with this result, the common set of hypha-specific genes was negatively regulated by both TCC1 and CaTUP1. These observations will provide new insights into CaTup1p-dependent transcriptional gene regulation in C. albicans...
  90. Takasato M, Kobayashi C, Okabayashi K, Kiyonari H, Oshima N, Asashima M, et al. Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development. Biochem Biophys Res Commun. 2008;373:648-52 pubmed publisher
    ..However, Trb2 mutant mice did not display any apparent phenotypes and no proteinuria was observed, indicating normal glomerular functions. These results suggest that Trb2 plays minimal roles during kidney and mouse development. ..
  91. Oono Y, Wakasa Y, Hirose S, Yang L, Sakuta C, Takaiwa F. Analysis of ER stress in developing rice endosperm accumulating beta-amyloid peptide. Plant Biotechnol J. 2010;8:691-718 pubmed publisher
  92. Moritake H, Shimonodan H, Marutsuka K, Kamimura S, Kojima H, Nunoi H. C-MYC rearrangement may induce an aggressive phenotype in anaplastic lymphoma kinase positive anaplastic large cell lymphoma: Identification of a novel fusion gene ALO17/C-MYC. Am J Hematol. 2011;86:75-8 pubmed publisher
    ..This new fusion may have possibly provoked the poor prognosis in this patient with ALK positive ALCL, and C-MYC rearrangement may indicate poor prognosis in ALCL. ..