Experts and Doctors on perilla in Japan
Sompornpailin K, Makita Y, Yamazaki M, Saito K. A WD-repeat-containing putative regulatory protein in anthocyanin biosynthesis in Perilla frutescens. Plant Mol Biol. 2002;50:485-95 pubmed
..We propose a model of genetic regulation in which the PFWD protein acts in signal transduction process in a variety of pathways through protein interaction with MYC proteins...
Tsuji M, Miyagawa K, Takeuchi T, Takeda H. [Pharmacological characterization and mechanisms of the novel antidepressive- and/or anxiolytic-like substances identified from Perillae Herba]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2008;28:159-67 pubmed
Nakashima Y, Sato A, Saito M. Effect of plant- and fish-oil derived n-3 polyunsaturated fatty acids on counteraction of n-3 fatty acid shortage in adult rats fed a lard diet. J Nutr Sci Vitaminol (Tokyo). 2009;55:346-52 pubmed
..Our studies clearly show that dietary EPA+DHA and ALA have different physiologic effects...
Izumi Y. [Dopaminergic neuroprotection via Nrf2-ARE pathway activation: identification of an activator from green perilla leaves]. Yakugaku Zasshi. 2013;133:983-8 pubmed
..In conclusion, the activation of the Nrf2-ARE pathway may be an effective means to prevent dopaminergic neuronal death in patients with Parkinson disease...
Asada T, Koi Y, Arakawa R, Zhu F, Sadaoka M, Tamura H. Isolation techniques for anthocyanidin 3,5-diglucosides and their related chemicals using supramolecules technique, and two solid-phase extraction cartridges. J Chromatogr A. 2014;1351:21-8 pubmed publisher
..3% with 86.1% purity using DPA-6S and 51.8% with 74.1% purity using DSC-SCX. Moreover, cyanidin 3,5-diglucoside yielded 43.4% with 97.0% purity using DPA-6S after partial acidic hydrolysis of protocyanin. ..
Masaki Y, Izumi Y, Matsumura A, Akaike A, Kume T. Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model. Eur J Pharmacol. 2017;798:26-34 pubmed publisher
..These results suggest that DDC prevents dopaminergic neurons from oxidative stress by upregulation of glial expression of HO-1. ..