Genomes and Genes
Experts and Doctors on peptide fragments in United States
Locale: United States
Topic: peptide fragments
Publications434 found, 100 shown here
- Chefalo P, Grandea A, Van Kaer L, Harding C. Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH. J Immunol. 2003;170:5825-33 pubmed..These results are consistent with alternate MHC-I Ag processing mechanisms that involve binding of peptides to MHC-I within acidic vacuolar compartments...
- Bergt C, Fu X, Huq N, Kao J, Heinecke J. Lysine residues direct the chlorination of tyrosines in YXXK motifs of apolipoprotein A-I when hypochlorous acid oxidizes high density lipoprotein. J Biol Chem. 2004;279:7856-66 pubmed..This mechanism might enable phagocytes to efficiently damage proteins when they destroy microbial proteins during infection or damage host tissue during inflammation. ..
- Nyarko A, Hare M, Hays T, Barbar E. The intermediate chain of cytoplasmic dynein is partially disordered and gains structure upon binding to light-chain LC8. Biochemistry. 2004;43:15595-603 pubmed..The induced folding of IC(1-289) upon LC8 binding suggests that LC8 could act through the intermediate chain to facilitate dynein assembly or regulate cargo-binding interactions. ..
- Niland B, Banki K, Biddison W, Perl A. CD8+ T cell-mediated HLA-A*0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple sclerosis. J Immunol. 2005;175:8365-78 pubmed..Moreover, Ab to TCR Vbeta14 abrogated cytotoxicity by HLA-A2-restricted TAL-specific TCL. Therefore, TAL-specific CTL may serve as a novel target for therapeutic intervention in patients with MS. ..
- Phartiyal P, Jones E, Robertson G. Heteromeric assembly of human ether-à-go-go-related gene (hERG) 1a/1b channels occurs cotranslationally via N-terminal interactions. J Biol Chem. 2007;282:9874-82 pubmed..Thus, N-terminal interactions mediate hERG 1a/1b assembly, a process whose perturbation may represent a new mechanism for disease. ..
- Perrotti D, Neviani P. From mRNA metabolism to cancer therapy: chronic myelogenous leukemia shows the way. Clin Cancer Res. 2007;13:1638-42 pubmed
- Smith A, Lambert P. Antimicrobial action of N-(n-dodecyl)diethanolamine on Escherichia coli: effects on enzymes and growing cultures. J Appl Microbiol. 2008;105:2161-8 pubmed publisher..The action on growing cells parallels that of penicillin and daptomycin, which bears a decanoyl residue that penetrates the cell membrane, causing leakage and membrane depolarization. ..
- Panchaud A, Scherl A, Shaffer S, von Haller P, Kulasekara H, Miller S, et al. Precursor acquisition independent from ion count: how to dive deeper into the proteomics ocean. Anal Chem. 2009;81:6481-8 pubmed publisher..5%) and achieved dynamic range (8 orders of magnitude at FDR < or = 0.5%), without any fractionation other than immuno-depletion of the seven most abundant proteins. ..
- Segu Z, Hussein A, Novotny M, Mechref Y. Assigning N-glycosylation sites of glycoproteins using LC/MSMS in conjunction with endo-M/exoglycosidase mixture. J Proteome Res. 2010;9:3598-607 pubmed publisher..This strategy was initially validated using model glycoproteins. It also proved to be useful in determining the glycosylation sites of blood serum glycoproteins. ..
- Zou W, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, et al. Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain. J Biol Chem. 2011;286:15095-105 pubmed publisher..Although this work indicated the interaction of A?42 with huPrP in the AD brain, the pathophysiological relevance of the iPrP/A?42 interaction remains to be established. ..
- Ladiwala A, Mora Pale M, Lin J, Bale S, Fishman Z, Dordick J, et al. Polyphenolic glycosides and aglycones utilize opposing pathways to selectively remodel and inactivate toxic oligomers of amyloid ?. Chembiochem. 2011;12:1749-58 pubmed publisher..We expect that these and related small molecules will be powerful chemical probes for investigating the conformational and cellular underpinnings of A?-mediated toxicity. ..
- Rowe B, Dixon B. Angiotensin III depressor action in the conscious rabbit is blocked by losartan but not PD 123319. Hypertension. 2000;35:130-4 pubmed..Paradoxically, the greater potency of angiotensin III as a vasodepressor belies the conclusion that the response is AT(1)-mediated, because AT(1) receptors have a greater affinity for angiotensin II versus angiotensin III. ..
- Smedira N, Dyke C, Koster A, Jurmann M, Bhatia D, Hu T, et al. Anticoagulation with bivalirudin for off-pump coronary artery bypass grafting: the results of the EVOLUTION-OFF study. J Thorac Cardiovasc Surg. 2006;131:686-92 pubmed..Further trials are warranted to assess whether anticoagulation with bivalirudin improves clinical outcomes. ..
- Tigno Aranjuez J, Lehmann P, Tary Lehmann M. Dissociated induction of cytotoxicity and DTH by CFA and CpG. J Immunother. 2009;32:389-98 pubmed publisher..These data have implications for CD8 T cell subunit vaccine design in which cytotoxicity versus DTH plays a key role in host defense. ..
- Mao G, Songdej N, Voora D, Goldfinger L, Del Carpio Cano F, Myers R, et al. Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants. Circulation. 2017;136:927-939 pubmed publisher..i>PCTP expression is associated with death/myocardial infarction in patients with cardiovascular disease. RUNX1 regulation of PCTP may play a role in the pathogenesis of platelet-mediated cardiovascular events. ..
- Dmitriev O, Jones P, Jiang W, Fillingame R. Structure of the membrane domain of subunit b of the Escherichia coli F0F1 ATP synthase. J Biol Chem. 1999;274:15598-604 pubmed..The change in direction of helical packing at the hinge region may be important in the functional interaction of the cytoplasmic domains...
- Smith B, Sengupta T, Singh I. Intraperoxisomal localization of very-long-chain fatty acyl-CoA synthetase: implication in X-adrenoleukodystrophy. Exp Cell Res. 2000;254:309-20 pubmed
- Fernandes R, Hirohata S, Engle J, Colige A, Cohn D, Eyre D, et al. Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. J Biol Chem. 2001;276:31502-9 pubmed..The findings provide an explanation for the sparing of cartilage in dermatosparaxis and, perhaps, for the relative sparing of some procollagen I-containing tissues. ..
- Senanayake P, Drazba J, Shadrach K, Milsted A, Rungger Brandle E, Nishiyama K, et al. Angiotensin II and its receptor subtypes in the human retina. Invest Ophthalmol Vis Sci. 2007;48:3301-11 pubmed..Local Ang II signaling may thus allow for autoregulation of neurovascular activity. Such an autonomous system could modulate the onset and severity of retinovascular disease. ..
- Mohmmad Abdul H, Baig I, LeVine H, Guttmann R, Norris C. Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture. Aging Cell. 2011;10:103-13 pubmed publisher..Together, the results demonstrate that the activation and interaction of CPs and CN are increased early in cognitive decline associated with AD and may help drive other pathologic processes during disease progression. ..
- Yabuta Y, Takagi H, Inouye M, Shinde U. Folding pathway mediated by an intramolecular chaperone: propeptide release modulates activation precision of pro-subtilisin. J Biol Chem. 2001;276:44427-34 pubmed
- Ghosh M, Peterson Y, Lanier S, Smrcka A. Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation. J Biol Chem. 2003;278:34747-50 pubmed
- Takada Y, Singh S, Aggarwal B. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 2004;279:15096-104 pubmed..Overall, our results demonstrate the identification of a p65 peptide that can selectively inhibit NF-kappaB activation induced by various inflammatory stimuli, down-regulate NF-kappaB-mediated gene expression, and up-regulate apoptosis. ..
- Moura A, Koc H, Chapman D, Killian G. Identification of proteins in the accessory sex gland fluid associated with fertility indexes of dairy bulls: a proteomic approach. J Androl. 2006;27:201-11 pubmed..We conclude that interactions among several proteins in accessory sex gland fluid explain a significant proportion of the variation in fertility scores of mature dairy sires. ..
- Rangachari V, Moore B, Reed D, Sonoda L, Bridges A, Conboy E, et al. Amyloid-beta(1-42) rapidly forms protofibrils and oligomers by distinct pathways in low concentrations of sodium dodecylsulfate. Biochemistry. 2007;46:12451-62 pubmed..It appears that endogenous oligomeric Abeta aggregates are stabilized by undefined processes that have not yet been incorporated into in vitro Abeta aggregation procedures...
- Lee Y, Marks A, Gureckas N, Lacro R, Nadal Ginard B, Kim D. Purification, characterization, and molecular cloning of a 60-kDa phosphoprotein in rabbit skeletal sarcoplasmic reticulum which is an isoform of phosphoglucomutase. J Biol Chem. 1992;267:21080-8 pubmed..Our results demonstrate that an isoform of PGM localized in junctional skeletal SR is the 60-kDa substrate of calmodulin-dependent protein kinase. ..
- Datta B, Ghosh A, Majumdar A, Datta R. Autoproteolysis of rat p67 generates several peptide fragments: the N-terminal fragment, p26, is required for the protection of eIF2alpha from phosphorylation. Biochemistry. 2007;46:3465-75 pubmed..Altogether, our data provide evidence that rat p67 has autoproteolytic activity that generates p26, which is required to block eIF2alpha from phosphorylation. ..
- Holstein Sherwood C, Gafken P, Martin D. Collision energy optimization of b- and y-ions for multiple reaction monitoring mass spectrometry. J Proteome Res. 2011;10:231-40 pubmed publisher..These results confirm the notion that y-ions are usually the first-choice transitions for MRM experiments but also demonstrate, for the first time, that b-ions can be viable targets as well, if the proper collision energies are used. ..
- Burrows G, Bebo B, Adlard K, Vandenbark A, Offner H. Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis. J Immunol. 1998;161:5987-96 pubmed..This new class of small soluble polypeptide may provide a template for designing human homologues useful in detecting and regulating potentially autopathogenic T cells. ..
- Tyler McMahon B, Stewart J, Farinas F, McCormick D, Richelson E. Highly potent neurotensin analog that causes hypothermia and antinociception. Eur J Pharmacol. 2000;390:107-11 pubmed..These studies provide the background for further testing of a stable, potent and long lasting neurotensin analog as a potential neuroleptic. ..
- Li X, Reddy M, Baev D, Edgerton M. Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. J Biol Chem. 2003;278:28553-61 pubmed..This study provides evidence for a novel function for yeast Ssa1/2 proteins as cell envelope binding receptors for Hst 5 that mediate fungicidal activity. ..
- Chen Y, Hagerman A. Characterization of soluble non-covalent complexes between bovine serum albumin and beta-1,2,3,4,6-penta-O-galloyl-D-glucopyranose by MALDI-TOF MS. J Agric Food Chem. 2004;52:4008-11 pubmed..Similar fragmentation patterns of PGG were found in ESI-MS and MALDI-TOF MS. The apparent stoichiometries of non-covalent BSA-PGG complexes were determined by MALDI-TOF MS...
- Flechtner J, Cohane K, Mehta S, Slusarewicz P, Leonard A, Barber B, et al. High-affinity interactions between peptides and heat shock protein 70 augment CD8+ T lymphocyte immune responses. J Immunol. 2006;177:1017-27 pubmed..These modified epitopes have the potential for creating successful multivalent vaccines for immunotherapy of both infectious disease and cancer. ..
- Varshavsky A. The N-end rule pathway of protein degradation. Genes Cells. 1997;2:13-28 pubmed..Ubiquitin is a 76-residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N-end rule pathway. ..
- Sitailo L, Tibudan S, Denning M. The protein kinase C delta catalytic fragment targets Mcl-1 for degradation to trigger apoptosis. J Biol Chem. 2006;281:29703-10 pubmed..Overall our results identify Mcl-1 as an important target for PKCdelta-cat that can mediate its pro-apoptotic effects on mitochondria to amplify the apoptotic signaling induced by a wide range of apoptotic stimuli. ..
- Fregoso O, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M. Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. PLoS Pathog. 2013;9:e1003496 pubmed publisher..Such drastic functional divergence within a lentiviral protein highlights a novel plasticity in the evolutionary dynamics of viral antagonists for restriction factors during lentiviral adaptation to its hosts. ..
- Wu Y, Valdivia H, Wehrens X, Anderson M. A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock. Circ Arrhythm Electrophysiol. 2016;9:e003180 pubmed publisher..PKA and CaMKII do not affect HR by a unique target site governing SR Ca(2+) uptake or release. HR acceleration may require an SR Ca(2+) content threshold. ..
- Furukawa K, Sopher B, Rydel R, Begley J, Pham D, Martin G, et al. Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem. 1996;67:1882-96 pubmed
- Lee K, Craven K, Niemi G, Hurley J. Mass spectrometric analysis of the kinetics of in vivo rhodopsin phosphorylation. Protein Sci. 2002;11:862-74 pubmed..The sensitivity of these methods was evaluated by using them to measure rhodopsin phosphorylation stimulated either by light flashes or by continuous illumination over a range of intensities. ..
- Park Y, Wei W, Zhou L, Nemeria N, Jordan F. Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit. Biochemistry. 2004;43:14037-46 pubmed..coli complex), as reflected by the overall activity of the entire complex. These studies add important information regarding recognition within this multienzyme complex class with an alpha(2) E1 assembly. ..
- Allen S, Garrett J, Rawale S, Jones A, Phillips G, Forni G, et al. Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo. J Immunol. 2007;179:472-82 pubmed
- Eun S, Banks S, Fischer J. Auxilin is essential for Delta signaling. Development. 2008;135:1089-95 pubmed publisher..We discuss these observations in the light of current models for the role of Epsin in ligand endocytosis and the role of ligand endocytosis in Notch signaling. ..
- Yoon S, Park D, Ryu J, Ozer H, Tep C, Shin Y, et al. JNK3 perpetuates metabolic stress induced by A? peptides. Neuron. 2012;75:824-37 pubmed publisher..This reveals AD as a metabolic disease that is under tight control by JNK3. ..
- Woodbury R, Topping T, Diamond D, Suciu D, Kumamoto C, Hardy S, et al. Complexes between protein export chaperone SecB and SecA. Evidence for separate sites on SecA providing binding energy and regulatory interactions. J Biol Chem. 2000;275:24191-8 pubmed..The region of SecA involved in activation of the complexes was defined as the extreme carboxyl-terminal 21 aminoacyl residues. ..
- Musingarimi P, Plumb M, Sodetz J. Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain. Biochemistry. 2002;41:11255-60 pubmed..Results from activity assays suggest that residues within this segment also mediate binding and incorporation of C8 into the MAC. ..
- Kim H, Tahara K, Maxwell J, Lalonde R, Fukuiwa T, Fujihashi K, et al. Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's disease. J Gene Med. 2007;9:88-98 pubmed
- Sturm R, Sheynkman G, Booth C, Smith L, Pedersen J, Li L. Absolute quantification of prion protein (90-231) using stable isotope-labeled chymotryptic peptide standards in a LC-MRM AQUA workflow. J Am Soc Mass Spectrom. 2012;23:1522-33 pubmed publisher..To the authors' knowledge, this is the first report on the use of a non-tryptic peptide in a LC-MRM AQUA workflow. ..
- Kannan R, Santhoshkumar P, Mooney B, Sharma K. Identification of subunit-subunit interaction sites in Î±A-WT crystallin and mutant Î±A-G98R crystallin using isotope-labeled cross-linker and mass spectrometry. PLoS ONE. 2013;8:e65610 pubmed publisher..This interaction could explain the conformational instability and aggregation nature of the mutant protein that results from incorrect folding and assembly. ..
- Schey K, Fowler J, Shearer T, David L. Modifications to rat lens major intrinsic protein in selenite-induced cataract. Invest Ophthalmol Vis Sci. 1999;40:657-67 pubmed..The heterogeneous cleavage pattern observed suggests that m-calpain is not the sole enzyme involved in MIP C-terminal processing in rat lens nuclei. ..
- Boules M, Warrington L, Fauq A, McCormick D, Richelson E. A novel neurotensin analog blocks cocaine- and D-amphetamine-induced hyperactivity. Eur J Pharmacol. 2001;426:73-6 pubmed
- Rodabaugh K, Mhawech Fauceglia P, Groth J, Lele S, Sood A. Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors. Int J Gynecol Pathol. 2007;26:10-5 pubmed..Furthermore, these results suggest that PDEF is a potential marker and target in ovarian cancer. ..
- Malhotra I, Wamachi A, Mungai P, Mzungu E, Koech D, Muchiri E, et al. Fine specificity of neonatal lymphocytes to an abundant malaria blood-stage antigen: epitope mapping of Plasmodium falciparum MSP1(33). J Immunol. 2008;180:3383-90 pubmed..We conclude that the fetal malaria response functions in a fully adaptive manner and that this response may serve to help protect the infant from severe malaria during infancy. ..
- Mandrekar S, Jiang Q, Lee C, Koenigsknecht Talboo J, Holtzman D, Landreth G. Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. J Neurosci. 2009;29:4252-62 pubmed publisher..These studies identify an important mechanism through which microglial cells participate in the maintenance of Abeta homeostasis, through their capacity to constitutively clear sAbeta peptides from the brain. ..
- Achuthan S, Chung B, Ghosh P, Rangachari V, Vaidya A. A modified Stokes-Einstein equation for A? aggregation. BMC Bioinformatics. 2011;12 Suppl 10:S13 pubmed publisher..The modification we are reporting is not only useful in A? aggregation but also will be important for accurate measurements in all protein aggregation systems. ..
- Guo H, Li X, Parker M, Waltenberger J, Becker P, Vander Kooi C. Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F. Biochemistry. 2013;52:7551-8 pubmed publisher..These data establish the basis for potent competitive binding of Sema3 to Nrp1 and provide a basis for the design of bivalent Nrp inhibitors. ..
- Nation D, Edland S, Bondi M, Salmon D, Delano Wood L, Peskind E, et al. Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults. Neurology. 2013;81:2024-7 pubmed publisher..The relationship between PP and CSF biomarkers is age-dependent and observed only in participants in the fifth and sixth decades of life. ..
- Piatkov K, Oh J, Liu Y, Varshavsky A. Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway. Proc Natl Acad Sci U S A. 2014;111:E817-26 pubmed publisher..We suggest that this capability of the Arg/N-end rule pathway underlies a multitude of its previously known but mechanistically unclear functions. ..
- Sur P, Sribnick E, Wingrave J, Nowak M, Ray S, Banik N. Estrogen attenuates oxidative stress-induced apoptosis in C6 glial cells. Brain Res. 2003;971:178-88 pubmed..Our results suggest that estrogen may have a protective role in minimizing glial cell apoptosis in neurological diseases such as demyelinating disease or central nervous system trauma. ..
- Clayton S, Acsell J, Crumbley A, Uber W. Cardiopulmonary bypass with bivalirudin in type II heparin-induced thrombocytopenia. Ann Thorac Surg. 2004;78:2167-9 pubmed..We report our experience using bivalirudin in 2 patients undergoing coronary artery bypass grafting. ..
- Loffredo J, Sidney J, Piaskowski S, Szymanski A, Furlott J, Rudersdorf R, et al. The high frequency Indian rhesus macaque MHC class I molecule, Mamu-B*01, does not appear to be involved in CD8+ T lymphocyte responses to SIVmac239. J Immunol. 2005;175:5986-97 pubmed..Our results suggest that the high frequency MHC class I molecule, Mamu-B*01, is not involved in SIV-specific CD8+ T lymphocyte responses. ..
- Mazumder S, Plesca D, Kinter M, Almasan A. Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis. Mol Cell Biol. 2007;27:3511-20 pubmed..The p18-cyclin E/Ku70 and Bax/Ku70 interactions provide a balance between apoptosis and the survival of cells exposed to genotoxic stress. ..
- Rosewell K, Al Alem L, Li F, Kelty B, Curry T. Identification of hepsin and protein disulfide isomerase A3 as targets of gelatinolytic action in rat ovarian granulosa cells during the periovulatory period. Biol Reprod. 2011;85:858-66 pubmed publisher..In the present study, proteomics has identified proteins that may be involved in novel ways in the complex cascades that are mediated by gelatinolytic MMPs during the periovulatory period. ..
- Ikeda S, Ma G, Ives D. Heterodimeric deoxynucleoside kinases of Lactobacillus acidophilus R-26: functional assignment of subunits using limited proteolysis controlled by end-product inhibitors. Biochemistry. 1994;33:5328-34 pubmed..Thus, this work presents a unique approach to the clarification of structure and function of enzymes composed of heterologous subunits. ..
- Sylvester S, Roy A. A 3'-truncated transferrin messenger RNA is expressed in rat testicular germ cells. Biol Reprod. 2002;67:895-9 pubmed..The findings suggest that a foreshortened transcript of the transferrin gene is produced in rat germ cells and that little or no protein is made from that transcript. ..
- Kim J, Chakrabarty P, Hanna A, March A, Dickson D, Borchelt D, et al. Normal cognition in transgenic BRI2-A? mice. Mol Neurodegener. 2013;8:15 pubmed publisher..Alternatively, A? aggregates may impact cognition by a mechanism that is not fully recapitulated in these BRI2-A? mouse models. ..
- Illuzzi J, Vickers C, Kmiec E. Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin. J Mol Neurosci. 2011;45:256-68 pubmed publisher..The lack of a proper p53-mediated signaling cascade or its alteration in the presence of DNA damage may contribute to the slow progression of cellular dysfunction which is a hallmark of HD pathology. ..
- Carragher N, Levkau B, Ross R, Raines E. Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin. J Cell Biol. 1999;147:619-30 pubmed..Thus, collagen fragments induce distinct integrin signals that lead to initiation of calpain-mediated cleavage of pp125(FAK), paxillin, and talin and dissolution of the focal adhesion complex. ..
- Liu Y, Qi W, Cowan J. Iron-sulfur cluster biosynthesis: functional characterization of the N- and C-terminal domains of human NFU. Biochemistry. 2009;48:973-80 pubmed publisher..This is consistent with electrostatic potential maps for bacterial homologues of the N- and C-terminal domains of human NFU, which most likely reflect the structural characteristics expected for full-length human NFU. ..
- Ney D, Blank R, Hansen K. Advances in the nutritional and pharmacological management of phenylketonuria. Curr Opin Clin Nutr Metab Care. 2014;17:61-8 pubmed publisher..Further research is needed to characterize the long-term efficacy of these new approaches for PKU management. ..
- Mukherjee A, Song E, Kihiko Ehmann M, Goodman J, Pyrek J, Estus S, et al. Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques. J Neurosci. 2000;20:8745-9 pubmed..Taken together these results suggest that the use of insulysin to hydrolyze Abeta peptides represents an alternative gene therapeutic approach to the treatment of Alzheimer's disease. ..
- Scott I, Blitz I, Pappano W, Maas S, Cho K, Greenspan D. Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. Nature. 2001;410:475-8 pubmed..We conclude that Tsg acts as a cofactor in chordin's antagonism of BMP signalling. ..
- Hu G, Wang X, Saunders D, Henderson M, Russell A, Herring B, et al. Modulation of myocardin function by the ubiquitin E3 ligase UBR5. J Biol Chem. 2010;285:11800-9 pubmed publisher..This study reveals an unexpected role for the ubiquitin E3 ligase UBR5 as an activator of smooth muscle differentiation through its ability to stabilize myocardin protein...
- Vig P, Hearst S, Shao Q, Lopez M, Murphy H, Safaya E. Glial S100B protein modulates mutant ataxin-1 aggregation and toxicity: TRTK12 peptide, a potential candidate for SCA1 therapy. Cerebellum. 2011;10:254-66 pubmed publisher..Taken together, our results suggest that glial S100B may augment degenerative changes in SCA1 PCs by modulating mutant ataxin-1 toxicity/solubility through an unknown signaling pathway. ..
- Piatkov K, Colnaghi L, Bekes M, Varshavsky A, Huang T. The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway. Mol Cell. 2012;48:926-33 pubmed publisher..Thus, in addition to its other functions in DNA repair and chromosome segregation, the Arg/N-end rule pathway regulates genomic stability through the degradation-mediated control of the autocleaved Usp1 deubiquitylase. ..
- Zhao N, Williams T, Zhou Z, Fronczek F, Sibrian Vazquez M, Jois S, et al. Synthesis of BODIPY-Peptide Conjugates for Fluorescence Labeling of EGFR Overexpressing Cells. Bioconjug Chem. 2017;28:1566-1579 pubmed publisher..The low cytotoxicity of the new conjugates and their remarkably high uptake into EGFR overexpressing cells renders them promising imaging agents for cancers overexpressing EGFR...
- Sellati T, Waldrop S, Salazar J, Bergstresser P, Picker L, Radolf J. The cutaneous response in humans to Treponema pallidum lipoprotein analogues involves cellular elements of both innate and adaptive immunity. J Immunol. 2001;166:4131-40 pubmed
- Reed M, Bell D. Clinical pharmacology of bivalirudin. Pharmacotherapy. 2002;22:105S-111S pubmed..Similarly, switching from heparin to bivalirudin at the time of PCI reduces both ischemic and bleeding events. ..
- Cormet Boyaka E, Hong J, Berdiev B, Fortenberry J, Rennolds J, Clancy J, et al. A truncated CFTR protein rescues endogenous DeltaF508-CFTR and corrects chloride transport in mice. FASEB J. 2009;23:3743-51 pubmed publisher..These findings identify complementary protein fragments as a viable in vivo approach for correcting disease-causing misfolding of plasma membrane proteins. ..
- Holmes E, Yen T, Thomas S, Joshi R, Nguyen A, Long T, et al. Human alpha 1,3/4 fucosyltransferases. Characterization of highly conserved cysteine residues and N-linked glycosylation sites. J Biol Chem. 2000;275:24237-45 pubmed..FucTs have highly conserved, potential N-linked sites, and our mass spectrometry analyses demonstrated that both N-linked sites are modified with oligosaccharides. ..
- Clementz A, Rogowski A, Pandya K, Miele L, Osipo C. NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications. Breast Cancer Res. 2011;13:R63 pubmed publisher..Targeting of PEA3 and/or Notch pathways might provide a new therapeutic strategy for triple-negative and possibly other breast cancer subtypes. ..
- Wafer L, Tzul F, Pandharipande P, Makhatadze G. Novel interactions of the TRTK12 peptide with S100 protein family members: specificity and thermodynamic characterization. Biochemistry. 2013;52:5844-56 pubmed publisher..This study has important implications for the rational drug design of inhibitors for the S100 proteins, which are involved in a variety of cancers and neurodegenerative diseases. ..
- Dicker I, Pedicord D, Seiffert D, Jamieson G, Greco N. Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity. Thromb Haemost. 2001;86:1065-9 pubmed
- Kuo S, Wang L, Yu S, Campbell C, Valiyaparambil S, Rance M, et al. The N-terminal basolateral targeting signal unlikely acts alone in the differential trafficking of membrane transporters in MDCK cells. Biochemistry. 2013;52:5103-5116 pubmed publisher..The interaction among the N-terminus, its partner(s), and the cellular basolateral targeting machinery needs to be further elucidated. ..
- Wang S, Wang Q, Crute B, Melnikova I, Keller S, Speck N. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol. 1993;13:3324-39 pubmed..Association of the CBF beta subunits does not extend the phosphate contacts in the binding site. We propose that CBF beta is a non-DNA-binding subunit of CBF and does not contact DNA directly. ..
- Eres A. Use of bivalirudin as the foundation anticoagulant during percutaneous peripheral interventions. J Invasive Cardiol. 2006;18:125-8 pubmed..Ischemic and bleeding events were low and comparable to those reported in the literature, suggesting that bivalirudin is safe to use in this population. ..