Genomes and Genes
Experts and Doctors on peptide fragments in United States
Locale: United States
Topic: peptide fragments
Publications529 found, 100 shown here
- Hildreth B, Werbeck J, Thudi N, Deng X, Rosol T, Toribio R. PTHrP 1-141 and 1-86 increase in vitro bone formation. J Surg Res. 2010;162:e9-17 pubmed publisher..The NLS and C-terminus have anabolic effects distinct from the N-terminus. This demonstrates the advantage of PTHrP 1-141 as a skeletal anabolic agent. ..
- Chen S, Yadav S, Surewicz W. Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues. J Biol Chem. 2010;285:26377-83 pubmed publisher..This insight may help explain the interplay between the postulated protective and pathogenic roles of PrP in AD and may contribute to the development of novel therapeutic strategies as well. ..
- Yadav R, Bhowmick S, Gorecki P, O Rourke J, Cone R. Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice. PLoS ONE. 2010;5:e11983 pubmed publisher..We hypothesized that the facilitation of experimental autoimmunity by PTX suggests that its influence on the in vivo immune response to auto-antigen may differ from its influence on non-self antigens...
- Santhoshkumar P, Raju M, Sharma K. ?A-crystallin peptide SDRDKFVIFLDVKHF accumulating in aging lens impairs the function of ?-crystallin and induces lens protein aggregation. PLoS ONE. 2011;6:e19291 pubmed publisher..The accumulation of such peptides in aging lenses may explain a novel mechanism for age-related crystallin aggregation and cataractogenesis. ..
- Jack C, Vemuri P, Wiste H, Weigand S, Lesnick T, Lowe V, et al. Shapes of the trajectories of 5 major biomarkers of Alzheimer disease. Arch Neurol. 2012;69:856-67 pubmed..Creating reliable models that describe the full trajectories of Alzheimer disease biomarkers will require significant additional longitudinal data in individual participants. ..
- Ali Q, Wu Y, Hussain T. Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats. Kidney Int. 2013;84:931-9 pubmed publisher..Our study highlights the importance of AT2R as a target for treating obesity-related hypertension. ..
- Welch W, Keiderling T, Kubelka J. Structural analyses of experimental 13C edited amide I' IR and VCD for peptide ?-sheet aggregates and fibrils using DFT-based spectral simulations. J Phys Chem B. 2013;117:10359-69 pubmed publisher..All four peptide models are shown to be antiparallel as had previously been assumed. However, in some cases our simulations are consistent with different register alignment of strands than originally proposed. ..
- Syu W, Kahan B, Kahan L. Epitopes of Escherichia coli ribosomal protein S13. J Protein Chem. 1989;8:701-17 pubmed..The remaining 11 monoclonal antibodies did not bind to these subfragments. These data provide molecular basis to the structure of S13 epitopes, whose in situ accessibility may reveal the S13 organization on the ribosome. ..
- Parente J, Goldenring J, Petropoulos A, Hellman U, Chew C. Purification, cloning, and expression of a novel, endogenous, calcium-sensitive, 28-kDa phosphoprotein. J Biol Chem. 1996;271:20096-101 pubmed..We propose that CSPP28 may play an important and ubiquitous role in the calcium signaling pathway. ..
- Sherwood A, Stroud M, Levery S, Holmes E. An amino acid region at the N-terminus of rat hepatoma alpha1-->2 fucosyltransferase modulates enzyme activity and interaction with lipids: strong preference for glycosphingolipids containing terminal Galbeta1-->3GalNAc-structures. Biochemistry. 2001;40:5708-19 pubmed
- Roher A, Weiss N, Kokjohn T, Kuo Y, Kalback W, Anthony J, et al. Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease. Biochemistry. 2002;41:11080-90 pubmed..To accurately assess the success of future therapeutic interventions, it is necessary to have a complete appreciation of the full scope and extent of AD pathology. ..
- Briaud I, Lingohr M, Dickson L, Wrede C, Rhodes C. Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells. Diabetes. 2003;52:974-83 pubmed..In contrast, glucose-induced p70(S6K) activation, in the same beta-cells, was mediated by a distinct signaling pathway independent of Ca(2+)/cAMP, most likely via mTOR-kinase acting as an "ATP-sensor." ..
- Hurwitz A, Ji Q. Autoimmune depigmentation following sensitization to melanoma antigens. Methods Mol Med. 2004;102:421-7 pubmed..As more sophisticated approaches to cancer therapy are developed, models such as these may be key in understanding how immunity to self-antigens can be manipulated to elicit tumor immunity. ..
- Sebestyen M, Budker V, Budker T, Subbotin V, Zhang G, Monahan S, et al. Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules. J Gene Med. 2006;8:852-73 pubmed
- Gerken T, Raman J, Fritz T, Jamison O. Identification of common and unique peptide substrate preferences for the UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases T1 and T2 derived from oriented random peptide substrates. J Biol Chem. 2006;281:32403-16 pubmed..Such information will be invaluable for identifying isoform-specific peptide acceptors, creating isoform-specific substrates, and predicting O-glycosylation sites. ..
- Dugger K, Zinn K, Weaver C, Bullard D, Barnum S. Effector and suppressor roles for LFA-1 during the development of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2009;206:22-7 pubmed publisher..Thus, LFA-1 acts as a key regulatory adhesion molecule during the development of EAE, serving both pro- and anti-inflammatory roles in disease pathogenesis. ..
- Ly T, Julian R. Ultraviolet photodissociation: developments towards applications for mass-spectrometry-based proteomics. Angew Chem Int Ed Engl. 2009;48:7130-7 pubmed publisher..Novel techniques made possible by this technology are poised to make substantial contributions to the field of proteomics. ..
- Han Y, Wang C, Park J, Niu L. Channel-opening kinetic mechanism of wild-type GluK1 kainate receptors and a C-terminal mutant. Biochemistry. 2012;51:761-8 pubmed publisher..Furthermore, as compared with the GluK2 kainate receptor, the GluK1 channel is faster to open, close, and desensitize by at least 2-fold, yet the EC(50) value of GluK1 is similar to that of GluK2. ..
- Sathananthan M, Farrugia L, Miles J, Piccinini F, Dalla Man C, Zinsmeister A, et al. Direct effects of exendin-(9,39) and GLP-1-(9,36)amide on insulin action, β-cell function, and glucose metabolism in nondiabetic subjects. Diabetes. 2013;62:2752-6 pubmed publisher..003). Endogenous glucose production and glucose disappearance did not differ significantly among groups. We conclude that exendin-(9,39), but not GLP-1-(9,36)amide, decreases insulin action and DI in healthy humans. ..
- Fraser I, Tavalin S, Lester L, Langeberg L, Westphal A, Dean R, et al. A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events. EMBO J. 1998;17:2261-72 pubmed
- Mosser E, Kasanov J, Forsberg E, Kay B, Ney P, Bresnick E. Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains. Biochemistry. 1998;37:13686-95 pubmed..Mutation of PPXY-1, but not PPXY-2, inhibited the transactivation function of NF-E2, providing support for the hypothesis that WW domain interactions are important for NF-E2-mediated transactivation. ..
- Zhu G, Mallery S, Schwendeman S. Stabilization of proteins encapsulated in injectable poly (lactide- co-glycolide). Nat Biotechnol. 2000;18:52-7 pubmed..We successfully applied this stabilization approach in both cylinder- and microsphere-injectable configurations and for delivery of angiogenic basic fibroblast growth factor and bone-regenerating bone morphogenetic protein-2. ..
- Kim M, Maier C, Reed D, Ho P, Deinzer M. Intramolecular interactions in chemically modified Escherichia coli thioredoxin monitored by hydrogen/deuterium exchange and electrospray ionization mass spectrometry. Biochemistry. 2001;40:14413-21 pubmed..These same sets of electrostatic and hydrogen bonding interactions were not predicted or observed for the smaller alkyl modification in Cys-ethyl-TRX. ..
- Januzzi J, Butler J, Jarolim P, Sattar N, Vijapurkar U, Desai M, et al. Effects of Canagliflozin on Cardiovascular Biomarkers in Older Adults With Type 2 Diabetes. J Am Coll Cardiol. 2017;70:704-712 pubmed publisher..A Safety and Efficacy Study of Canagliflozin in Older Patients [55 to 80 Years of Age] With Type 2 Diabetes Mellitus; NCT01106651). ..
- Garcia J, Guerriero K, Keen K, Kenealy B, Seminara S, Terasawa E. Kisspeptin and Neurokinin B Signaling Network Underlies the Pubertal Increase in GnRH Release in Female Rhesus Monkeys. Endocrinology. 2017;158:3269-3280 pubmed publisher..We speculate that this cooperative mechanism by the kisspeptin and NKB network underlies the pubertal increase in GnRH release in female monkeys. ..
- Acharya S, Rodriguez I, Moreira E, Midura R, Misono K, Todres E, et al. SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan. J Biol Chem. 1998;273:31599-606 pubmed
- Boules M, McMahon B, Warrington L, Stewart J, Jackson J, Fauq A, et al. Neurotensin analog selective for hypothermia over antinociception and exhibiting atypical neuroleptic-like properties. Brain Res. 2001;919:1-11 pubmed..Thus, NT77L selectively caused hypothermia, over antinociception, while exhibiting atypical neuroleptic-like effects. ..
- Brugos B, Hochhaus G. Metabolism of dynorphin A(1-13). Pharmazie. 2004;59:339-43 pubmed..This article is a general review of the metabolism of dynorphin A(1-13) in human plasma and CSF. ..
- Edberg D, Bruce J, Siems W, Reeves R. In vivo posttranslational modifications of the high mobility group A1a proteins in breast cancer cells of differing metastatic potential. Biochemistry. 2004;43:11500-15 pubmed..These findings suggest that examination of the PTM patterns on HMGA1 proteins may provide valuable information concerning the physiological and phenotypic state of mammalian cells. ..
- Koenigsknecht J, Landreth G. Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism. J Neurosci. 2004;24:9838-46 pubmed..These data provide evidence for phagocytic uptake of fAbeta through a receptor-mediated, nonclassical phagocytic mechanism. ..
- Mohmmad Abdul H, Butterfield D. Protection against amyloid beta-peptide (1-42)-induced loss of phospholipid asymmetry in synaptosomal membranes by tricyclodecan-9-xanthogenate (D609) and ferulic acid ethyl ester: implications for Alzheimer's disease. Biochim Biophys Acta. 2005;1741:140-8 pubmed..Rather, other mechanisms that could modulate the function of flippase might be important in the modulation of phospholipid asymmetry. The results of this study are discussed with relevance to neuronal loss in the AD brain. ..
- Dasgupta B, Antharavally B, Tepp W, Evenson M. Botulinum neurotoxin types A, B, and E: fragmentations by autoproteolysis and other mechanisms including by O-phenanthroline-dithiothreitol, and association of the dinucleotides NAD(+)/NADH with the heavy chain of the three neurotoxins. Protein J. 2005;24:337-68 pubmed
- Li W, Aldrich R. State-dependent block of BK channels by synthesized shaker ball peptides. J Gen Physiol. 2006;128:423-41 pubmed..Furthermore, our results from two BK channel mutations demonstrate that similar types of interactions between ball peptides and channels are shared by BK and other K(+) channel types. ..
- Rusk A, McKeegan E, Haviv F, Majest S, Henkin J, Khanna C. Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancers. Clin Cancer Res. 2006;12:7444-55 pubmed..These results support the safety and activity of ABT-526 and ABT-510 in dogs with naturally occurring malignant cancers. Data from this preclinical trial support the development of TSP-1 mimetic peptides as anticancer agents. ..
- Chen J, Enns C. The Cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells. J Biol Chem. 2007;282:6201-9 pubmed..These results suggest that although holo-Tf binding to the ectodomain is necessary, the cytoplasmic domain of TfR2 is largely responsible for its stabilization by holo-Tf. ..
- Sorkina T, Richards T, Rao A, Zahniser N, Sorkin A. Negative regulation of dopamine transporter endocytosis by membrane-proximal N-terminal residues. J Neurosci. 2009;29:1361-74 pubmed publisher..Thus, our studies reveal a new link between DAT endocytosis and conformation-dependent uptake activity that represents a novel mode for regulating DAT function. ..
- Sultana R, Perluigi M, Butterfield D. Proteomics identification of oxidatively modified proteins in brain. Methods Mol Biol. 2009;564:291-301 pubmed publisher..Separated proteins are identified following tryptic digestion, mass spectrometry, and interrogation of appropriate databases. ..
- Burgoyne A, Phillips Mason P, Burden Gulley S, Robinson S, Sloan A, Miller R, et al. Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration. Cancer Res. 2009;69:6960-8 pubmed publisher..These data suggest that loss of cell surface PTPmu by proteolysis generates catalytically active PTPmu fragments that contribute to migration and survival of glioblastoma cells. ..
- Olsen J, Dimaio J, Doran T, Brown C, Nilsson B, Dewhurst S. Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide. J Biol Chem. 2012;287:11842-9 pubmed publisher..Taken together, these data suggest that in the in vivo environment, PAP(248-286) is likely to form fibrils efficiently, thus providing an explanation for the presence of SEVI in human semen. ..
- Ghosh S, Willard B, Comhair S, Dibello P, Xu W, Shiva S, et al. Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma. Antioxid Redox Signal. 2013;18:412-23 pubmed publisher..However, mechanisms for the reduced activity are unknown. We hypothesized that loss of asthmatic SOD activity is due to greater susceptibility to oxidative inactivation...
- Cummings J, Zhong K, Kinney J, Heaney C, Moll Tudla J, Joshi A, et al. Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease. Alzheimers Res Ther. 2016;8:4 pubmed publisher..RXR agonists warrant further investigations as AD therapies. ClinicalTrials.gov identifier NCT01782742 . Registered 29 January 2013. ..
- Abouezzeddine O, Lala A, Khazanie P, Shah R, Ho J, Chen H, et al. Evaluation of a provocative dyspnea severity score in acute heart failure. Am Heart J. 2016;172:34-41 pubmed publisher..The statistical characteristics of a pDS based on feasible provocation measures do not support its potential as a robust dyspnea assessment tool in AHF. ..
- Vora A, Peterson E, McCoy L, Garratt K, Kutcher M, Marso S, et al. The Impact of Bleeding Avoidance Strategies on Hospital-Level Variation in Bleeding Rates Following Percutaneous Coronary Intervention: Insights From the National Cardiovascular Data Registry CathPCI Registry. JACC Cardiovasc Interv. 2016;9:771-779 pubmed publisher..Further analyses are required to determine the remaining approximately 70% causes of variation in percutaneous coronary intervention bleeding seen among hospitals. ..
- Dai Y, Molazemhosseini A, Liu C. In Vitro Quantified Determination of ?-Amyloid 42 Peptides, a Biomarker of Neuro-Degenerative Disorders, in PBS and Human Serum Using a Simple, Cost-Effective Thin Gold Film Biosensor. Biosensors (Basel). 2017;7: pubmed publisher..Interference study of this biosensor was carried out in the presence of Tau protein antigen. Excellent specificity of this ?-amyloid 42 biosensor was demonstrated without interference from other species, such as T-tau protein. ..
- Papac D, Thornburg K, Bullesbach E, Crouch R, Knapp D. Palmitylation of a G-protein coupled receptor. Direct analysis by tandem mass spectrometry. J Biol Chem. 1992;267:16889-94 pubmed..These results prove the modification of cysteines 322 and 323 with palmitic acid in bovine rhodopsin, and illustrate the utility of mass spectrometry to characterize the post-translational modifications in G-protein coupled receptors. ..
- Talafous J, Marcinowski K, Klopman G, Zagorski M. Solution structure of residues 1-28 of the amyloid beta-peptide. Biochemistry. 1994;33:7788-96 pubmed
- Rubinfeld B, Souza B, Albert I, Munemitsu S, Polakis P. The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J Biol Chem. 1995;270:5549-55 pubmed..Thus, APC forms distinct heteromeric complexes containing combinations of alpha-catenin, beta-catenin, and plakoglobin which are independent from the cadherin-catenin complexes. ..
- Lerman J, Robblee J, Fairman R, Hughson F. Structural analysis of the neuronal SNARE protein syntaxin-1A. Biochemistry. 2000;39:8470-9 pubmed..They also suggest a potential role for the neuronal Sec1 protein (nSec1) in preventing the formation of syntaxin multimers. ..
- Gurm H, Bhatt D. Thrombin, an ideal target for pharmacological inhibition: a review of direct thrombin inhibitors. Am Heart J. 2005;149:S43-53 pubmed
- Hoffman D, Carroll D, Martinez N, Hackert M. Solution structure of a conserved domain of antizyme: a protein regulator of polyamines. Biochemistry. 2005;44:11777-85 pubmed..This structural model provides an essential framework for an improved future understanding of how the different parts of antizyme play their roles in polyamine regulation. ..
- Cameron D, Galas L, Jiang Y, Raoult E, Vaudry D, Komuro H. Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide. Neuroscience. 2007;146:697-712 pubmed..Therefore, endogenous PACAP may provide a cue that regulates granule cell migration in a cerebellar cortical-layer-specific manner. ..
- Zhan S, Zhao H, J White A, Minami M, Pignataro G, Yang T, et al. Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains. J Cereb Blood Flow Metab. 2009;29:698-706 pubmed publisher..We conclude that brain ischemia attenuates PC2 and PC2-mediated neuropeptide processing. This attenuation may play a role in the pathology of ischemic brain injury. ..
- Sackmann Sala L, Ding J, Frohman L, Kopchick J. Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res. 2009;19:471-7 pubmed publisher..Although the molecular mechanisms linking the identified proteins to GH and IGF-1 biological activity remain to be clarified, the results suggest that they represent potential biomarkers of GH and/or IGF-1 action. ..
- Falkowski M, Thomas D, Groblewski G. Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini. J Biol Chem. 2010;285:35558-66 pubmed publisher..These data demonstrate a functional role for complexin 2 outside the nervous system and indicate that it participates in the Ca(2+)-sensitive regulatory pathway for zymogen granule exocytosis...
- Diao H, Aplin J, Xiao S, Chun J, Li Z, Chen S, et al. Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus. Biol Reprod. 2011;84:255-65 pubmed publisher..These results demonstrate that pathways downstream of LPA3 are involved in the dynamic remodeling of ECM in the peri-implantation uterus. ..
- Olkhanud P, Mughal M, Ayukawa K, Malchinkhuu E, Bodogai M, Feldman N, et al. DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid ?-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease. Vaccine. 2012;30:1650-8 pubmed publisher..Hence, we propose that vaccines targeting A?(1-11) can efficiently combat AD-induced pathological alterations and provide survival benefit in patients with AD. ..
- Piatkov K, Brower C, Varshavsky A. The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments. Proc Natl Acad Sci U S A. 2012;109:E1839-47 pubmed publisher..In conjunction with other apoptosis-suppressing circuits, the Arg/N-end rule pathway contributes to thresholds that prevent a transient or otherwise weak proapoptotic signal from reaching the point of commitment to apoptosis. ..
- Blaha M, Cainzos Achirica M, Greenland P, McEvoy J, Blankstein R, Budoff M, et al. Role of Coronary Artery Calcium Score of Zero and Other Negative Risk Markers for Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2016;133:849-58 pubmed publisher..These results may help guide discussions on the identification of individuals less likely to receive net benefit from lifelong preventive pharmacotherapy. ..
- Kashishian A, Howard M, Loh C, Gallatin W, Hoekstra M, Lai Y. AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region. J Biol Chem. 1998;273:27412-9 pubmed..These results demonstrated that AKAP79 can bind to and inhibit calcineurin activity in vivo, suggesting a physiological role for AKAP79-calcineurin interaction in NFAT-mediated signaling. ..
- Ozment C, Barchue J, DeLucas L, Chattopadhyay D. Structural study of Escherichia coli NAD synthetase: overexpression, purification, crystallization, and preliminary crystallographic analysis. J Struct Biol. 1999;127:279-82 pubmed..766, c = 74.17 A and alpha = beta = 90 degrees, gamma = 120 degrees. The structure of the complex has been determined using the molecular replacement method. ..
- Park Y, Kim Y, Adams M. Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc Natl Acad Sci U S A. 2002;99:11423-8 pubmed..These findings support a theory of coevolution for NMU and Drosophila PRXa peptides and their respective receptors. ..
- Saw J, Lincoff A, Desmet W, Betriu A, Rutsch W, Wilcox R, et al. Lack of clopidogrel pretreatment effect on the relative efficacy of bivalirudin with provisional glycoprotein IIb/IIIa blockade compared to heparin with routine glycoprotein IIb/IIIa blockade: a REPLACE-2 substudy. J Am Coll Cardiol. 2004;44:1194-9 pubmed..However, pretreatment was associated with a trend towards lower clinical events after PCI. ..
- Peterson K, Sadowsky J, Scheef E, Pal S, Kourentzi K, Willson R, et al. A fluorescence polarization assay for identifying ligands that bind to vascular endothelial growth factor. Anal Biochem. 2008;378:8-14 pubmed publisher..This 384-well format assay is tolerant to dimethyl sulfoxide (DMSO, up to 4% [v/v]) and has a Z' factor of 0.76, making it useful for identifying molecules that associate with the receptor-binding surface of the VEGF dimer. ..
- Varvel N, Bhaskar K, Patil A, Pimplikar S, Herrup K, Lamb B. Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci. 2008;28:10786-93 pubmed publisher..Together, our data suggest that low molecular weight aggregates of Abeta induce neuronal cell cycle re-entry in mouse models of Alzheimer's disease. ..
- Brower C, Piatkov K, Varshavsky A. Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway. Mol Cell. 2013;50:161-71 pubmed publisher..The discovery that neurodegeneration-associated natural fragments of TDP43, Tau, ?-synuclein, and APP can be selectively destroyed by the Arg/N-end rule pathway suggests that this pathway counteracts neurodegeneration. ..
- Szente B, Subramaniam P, Johnson H. Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133). J Immunol. 1995;155:5617-22 pubmed..Furthermore, the data support previous studies that demonstrated that intracellular IFN-gamma plays a role in cell activation. ..
- Robinson N, Lapic S, Welter J, Eckert R. S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. J Biol Chem. 1997;272:12035-46 pubmed..No loricrin, cystatin A, or elafin peptides were detected. ..
- Fitzgerald L, Patterson J, Conklin D, Horlick R, Largent B. Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides. J Pharmacol Exp Ther. 1998;287:448-56 pubmed..These observations suggest that the antagonist effects in vivo of M40, and perhaps other chimeric peptides, are not mediated via direct interactions with the galanin receptor 1 receptor. ..
- Yuan C, Byeon I, Li Y, Tsai M. Structural analysis of phospholipase A2 from functional perspective. 1. Functionally relevant solution structure and roles of the hydrogen-bonding network. Biochemistry. 1999;38:2909-18 pubmed..Our results also suggest that, while the D99.H48 catalytic diad is the key catalytic machinery of PLA2, it also helps to maintain conformational integrity. ..
- Ma K, Simantov R, Zhang J, Silverstein R, Hajjar K, McCrae K. High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. J Biol Chem. 2000;275:15541-8 pubmed..Finally, surface plasmon resonance studies revealed high affinity binding between annexin II and beta(2)GPI. These results demonstrate that annexin II mediates the binding of beta(2)GPI to endothelial cells. ..
- Liu S, Lane W, Lienhard G. Cloning and preliminary characterization of a 105 kDa protein with an N-terminal kinase-like domain. Biochim Biophys Acta. 2000;1517:148-52 pubmed..By immunoblotting, it was found that the protein was widely expressed in mouse tissues, and concentrated in the cytosol and low density microsome fractions of 3T3-L1 adipocytes. ..
- Zhang D, Kaufman P, Gao G, Saunders R, Ma J. Intravitreal injection of plasminogen kringle 5, an endogenous angiogenic inhibitor, arrests retinal neovascularization in rats. Diabetologia. 2001;44:757-65 pubmed..These observations suggest that intravitreal delivery of angiogenic inhibitors could have therapeutic benefits in neovascular diseases of the retina. ..
- Raisler B, Berns K, Grant M, Beliaev D, Hauswirth W. Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization. Proc Natl Acad Sci U S A. 2002;99:8909-14 pubmed
- Hofstetter H, Shive C, Forsthuber T. Pertussis toxin modulates the immune response to neuroantigens injected in incomplete Freund's adjuvant: induction of Th1 cells and experimental autoimmune encephalomyelitis in the presence of high frequencies of Th2 cells. J Immunol. 2002;169:117-25 pubmed..Together, the results suggest that microbial products, such as PT, could contribute to the initiation of autoimmune disease by modulating the interaction between the innate and adaptive immune system in the response to self Ags. ..
- Ball D, Rachfal A, Kemper S, Brigstock D. The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. J Endocrinol. 2003;176:R1-7 pubmed..Thus, CTGF isoforms comprising essentially module 4 are intrinsically functional in the absence of the other constituent modules of CTGF...
- Senior A, Muharemagic A, Wilke Mounts S. Assembly of the stator in Escherichia coli ATP synthase. Complexation of alpha subunit with other F1 subunits is prerequisite for delta subunit binding to the N-terminal region of alpha. Biochemistry. 2006;45:15893-902 pubmed..The cytoplasmic fragment of the b subunit (bsol) did not bind to isolated alpha. It might also be that complexation of alpha with beta subunits is prerequisite for direct binding of stator b subunit to the F1-sector. ..
- Dai Y, Dudek N, Li Q, Fowler S, Muma N. Striatal expression of a calmodulin fragment improved motor function, weight loss, and neuropathology in the R6/2 mouse model of Huntington's disease. J Neurosci. 2009;29:11550-9 pubmed publisher..Together, these results suggest that disrupting CaM-htt interaction may provide a new therapeutic strategy for HD. ..
- Briody S, Boules M, Oliveros A, Fauq I, Richelson E. Chronic NT69L potently prevents drug-induced disruption of prepulse inhibition without causing tolerance. Behav Brain Res. 2010;207:118-24 pubmed publisher..The modulatory role of NT69L on the dopaminergic and serotonergic neurotransmission systems both of which are implicated in the pathophysiology of schizophrenia is discussed. ..
- Boules M, Oliveros A, Liang Y, Williams K, Shaw A, Robinson J, et al. A neurotensin analog, NT69L, attenuates intravenous nicotine self-administration in rats. Neuropeptides. 2011;45:9-16 pubmed publisher..These data support further study of the effects of NT analogs on attenuating the reinforcing effects of psychostimulants. ..
- Adamus G, Brown L, Andrew S, Meza Romero R, Burrows G, Vandenbark A. Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice. Invest Ophthalmol Vis Sci. 2012;53:406-12 pubmed publisher..However, to achieve full therapeutic benefit, more doses may be needed. These findings suggest a possible clinical application of this novel class of T-cell-tolerizing drugs for patients with optic neuritis. ..
- Joyner J, Keuper K, Cowan J. DNA nuclease activity of Rev-coupled transition metal chelates. Dalton Trans. 2012;41:6567-78 pubmed publisher..Moreover, the studies confirm high selectivity for the target HIV RRE RNA at the most likely dosage concentrations, lending further support to the feasibility of designing and applying targeted catalytic metallodrugs. ..
- Malovichko M, Sabo T, Maurer M. Ligand binding to anion-binding exosites regulates conformational properties of thrombin. J Biol Chem. 2013;288:8667-78 pubmed publisher..The results obtained support the proposal that thrombin is a highly dynamic protein. The transmission of ligand-specific local and long range conformational events is proposed to help regulate this multifunctional enzyme. ..
- Han S, Newsome B, Hennig B. Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells. Toxicology. 2013;306:1-8 pubmed publisher..These data indicate that TiO2 NPs can induce endothelial inflammatory responses via redox-sensitive cellular signaling pathways. ..
- Thompson C, Korley L. Harnessing Supramolecular and Peptidic Self-Assembly for the Construction of Reinforced Polymeric Tissue Scaffolds. Bioconjug Chem. 2017;28:1325-1339 pubmed publisher..In particular, we focus on how the design and structure impact their mechanical properties and interaction with the cellular environment...
- Zhang Y, McCormick L, Gilliam A. Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. J Invest Dermatol. 2003;121:713-9 pubmed..LAP may be a potential new therapy in scleroderma and other TGF-beta-driven fibrosing disease that targets TGF-beta more specifically, without affecting systemic critical roles of TGF-beta on immune cell function. ..
- Hayes G, Enns C, Lucas J. Identification of the O-linked glycosylation site of the human transferrin receptor. Glycobiology. 1992;2:355-9 pubmed..Amino acid sequence analysis reveals that the site of O-glycosylation is Thr-104. Mass spectral analysis is consistent with the presence of a Gal-GalNAc core with predominantly two sialic acid residues. ..
- Smith W, Milam A, Dugger D, Arendt A, Hargrave P, Palczewski K. A splice variant of arrestin. Molecular cloning and localization in bovine retina. J Biol Chem. 1994;269:15407-10 pubmed..This specificity of localization to the outer segment is consistent with a role of p44 in the phototransduction cascade. ..
- Earnhardt J, Qian M, Tu C, Lakkis M, Bergenhem N, Laipis P, et al. The catalytic properties of murine carbonic anhydrase VII. Biochemistry. 1998;37:10837-45 pubmed..This suggests a role for the amino-terminal end in enhancing proton transfer in catalysis by carbonic anhydrase. ..
- Xu X, Shi Y, Wu X, Gambetti P, Sui D, Cui M. Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1. J Biol Chem. 1999;274:32543-6 pubmed..These data suggest that PS-1 may associate with a PDZ-like domain-containing protein in vivo and thus may participate in receptor or channel clustering and intracellular signaling events in the brain. ..
- Gilbert M, Shaw W, Long J, Nelson K, Drobny G, Giachelli C, et al. Chimeric peptides of statherin and osteopontin that bind hydroxyapatite and mediate cell adhesion. J Biol Chem. 2000;275:16213-8 pubmed..This fusion peptide framework may thus provide a straightforward design for immobilizing bioactive sequences on hydroxyapatite for biomaterials, tissue engineering, and vaccine applications. ..