Genomes and Genes
Experts and Doctors on peptide fragments in United States
Locale: United States
Topic: peptide fragments
Publications203 found, 100 shown here
- Nguyen B, Chen H, Kobor M, Greenblatt J, Legault P, Omichinski J. Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB. Biochemistry. 2003;42:1460-9 pubmed..These results provide new information about the recognition of acidic-rich activation domains involved in transcriptional regulation, and provide insights into how TFIIF and TFIIB regulate the FCP1 phosphatase activity in vivo. ..
- Wegmann K, Bouwer H, Gregory C, Whitham R, Hinrichs D. Targeting T cells responsive to the priming epitope prevent the relapsing phase of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2013;260:74-81 pubmed publisher..Our studies show that the peptide-octamers, which target the T cells stimulated by the priming encephalitogen, but not other candidate encephalitogens, prevent rEAE. ..
- HIRBAWI J, Bialkowska K, Bledzka K, Liu J, Fukuda K, Qin J, et al. The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation. J Biol Chem. 2017;292:14258-14269 pubmed publisher..Our findings indicate that the extreme C terminus of K2 is essential for integrin co-activation and highlight the importance of an atypical architecture of the K2 FERM domain in regulating integrin activation. ..
- Rowley R, Burkhardt A, Chao H, Matsueda G, Bolen J. Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation. J Biol Chem. 1995;270:11590-4 pubmed
- Yoder Hill J, Pause A, Sonenberg N, Merrick W. The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A. J Biol Chem. 1993;268:5566-73 pubmed
- Nekrasova T, Shive C, Gao Y, Kawamura K, Guardia R, Landreth G, et al. ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis. J Immunol. 2005;175:2374-80 pubmed..Collectively, the data show that ERK1 is not critical for the function of peripheral T cells in the response to self and foreign Ags and in T cell-mediated autoimmunity, and suggest that its loss can be compensated by ERK2. ..
- Sirohi S, Aldrich J, Walker B. Species differences in the effects of the ?-opioid receptor antagonist zyklophin. Alcohol. 2016;51:43-9 pubmed publisher..These results identify species differences in zyklophin efficacy that, given the rising interest in the development of short-duration KOR antagonists, should provide valuable information for therapeutic development efforts. ..
- Towndrow K, Jia Z, Lo H, Person M, Monks T, Lau S. 11-Deoxy,16,16-dimethyl prostaglandin E2 induces specific proteins in association with its ability to protect against oxidative stress. Chem Res Toxicol. 2003;16:312-9 pubmed..The present studies provide insights into potential downstream targets of PG signaling. ..
- DiNovo A, Schey K, Vachon W, McGuffie E, Olson J, Vincent T. ADP-ribosylation of cyclophilin A by Pseudomonas aeruginosa exoenzyme S. Biochemistry. 2006;45:4664-73 pubmed..Our results support that ExoS ADP-ribosylates and affects the function of the cytosolic protein, CpA, with the predominant functional effect relating to interference of CpA-cellular protein interactions. ..
- Kim J, Miller V, Levites Y, West K, Zwizinski C, Moore B, et al. BRI2 (ITM2b) inhibits Abeta deposition in vivo. J Neurosci. 2008;28:6030-6 pubmed publisher..These studies demonstrate that BRI2 is a novel mediator of Abeta deposition in vivo. ..
- Nagase H, Brew K. Amino acid sequence of a 32-residue region around the thiol ester site in duck ovostatin. FEBS Lett. 1987;222:83-8 pubmed..The results indicate that ovostatin is a close relative to plasma alpha-macroglobulins and may share a common ancestor with C3 and C4. ..
- Rubinstein M, Kadima A, Salem M, Nguyen C, Gillanders W, Cole D. Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells. J Immunol. 2002;169:4928-35 pubmed..These studies show for the first time that IL-15 is capable of augmenting the primary CD8(+) T cell response to vaccination and contribute to the basis for future experiments exploring the clinical role of IL-15. ..
- Klase Z, Donio M, Blauvelt A, Marx P, Jeang K, Smith S. A peptide-loaded dendritic cell based cytotoxic T-lymphocyte (CTL) vaccination strategy using peptides that span SIV Tat, Rev, and Env overlapping reading frames. Retrovirology. 2006;3:1 pubmed publisher..However, conclusive in vivo control of a challenge inoculation of SIVmac239 was not observed suggesting that CTL epitopes within densely overlapping reading frames are also subject to escape mutations...
- Aikman J, O Steen B, Silver X, Torres R, Boslaugh S, Blackband S, et al. Alpha-II-spectrin after controlled cortical impact in the immature rat brain. Dev Neurosci. 2006;28:457-65 pubmed..Distinct proteolytic products resulting from the degradation of the cytoskeletal protein alpha-II-spectrin by calpain and caspase 3 were readily detectable in cortical brain parenchyma and cerebrospinal fluid after TBI in immature rats. ..
- Che M, Boja E, Yoon H, Gruschus J, Jaffe H, Stauffer S, et al. Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains. Cell Signal. 2005;17:1276-88 pubmed
- Gloor J, Stegall M. ABO incompatible kidney transplantation. Curr Opin Nephrol Hypertens. 2007;16:529-34 pubmed..ABO incompatible kidney transplantation is an effective therapy, and will become more widely implemented in the future. ..
- Jenkins C, Cardona D, Bowers J, Oliai B, Allan R, Normann S. The utility of C4d, C9, and troponin T immunohistochemistry in acute myocardial infarction. Arch Pathol Lab Med. 2010;134:256-63 pubmed publisher..Patchy loss of Troponin T in some cases of histologically normal myocardium limited its usefulness as a sole marker of infarction. ..
- Moore K, Bryant Z, Ghatnekar G, Singh U, Gourdie R, Potts J. A synthetic connexin 43 mimetic peptide augments corneal wound healing. Exp Eye Res. 2013;115:178-88 pubmed publisher..These results suggest ?CT1, when applied in a sustained release system, acts as a beneficial wound healing treatment. ..
- Polfer N, Bohrer B, Plasencia M, Paizs B, Clemmer D. On the dynamics of fragment isomerization in collision-induced dissociation of peptides. J Phys Chem A. 2008;112:1286-93 pubmed publisher..It is demonstrated here that cyclic and linear a4 structures can interconvert freely as a result of collisional activation, implying that isomerization takes place prior to dissociation. ..
- Carlson J, Brumme Z, Rousseau C, Brumme C, Matthews P, Kadie C, et al. Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag. PLoS Comput Biol. 2008;4:e1000225 pubmed publisher..Phylogenetic dependency networks represent a major step toward systematically expanding our understanding of CTL escape to diverse populations and whole viral genes. ..
- Mondello S, Robicsek S, Gabrielli A, Brophy G, Papa L, Tepas J, et al. ?II-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients. J Neurotrauma. 2010;27:1203-13 pubmed publisher..The time course of SBDPs in nonsurvivors also differed from that of survivors. These results suggest that CSF SBDP levels can predict injury severity and mortality after severe TBI, and can be useful complements to clinical assessment. ..
- Plumb M, Scibek J, Barber T, Dunlap R, Platteborze P, Sodetz J. Chimeric and truncated forms of human complement protein C8 alpha reveal binding sites for C8 beta and C8 gamma within the membrane attack complex/perforin region. Biochemistry. 1999;38:8478-84 pubmed..They also suggest that the N-terminal modules in C8 alpha are important for C9 binding and/or expression of C8 activity. ..
- Deucher A, Nagpal S, Chandraratna R, Di Sepio D, Robinson N, Dashti S, et al. The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity. Int J Oncol. 2000;17:1195-203 pubmed..This suggests that the c-terminal hydrophobic domain has an important role in determining the intracellular localization of TIG3. In addition, GFP-TIG31-164 retains the ability to inhibit cell function, while GFP-TIG31-134 is inactive. ..
- Ma Z, Chow K, Csuhai E, Hersh L. The use of proteolysis to study the structure of nardilysin. Arch Biochem Biophys. 2002;401:198-204 pubmed..Treatment of nardilysin(V8) with trypsin generated primarily the 92 kDa form which was inactive. Attempts to express nardilysin as a 105 kDa truncated N-terminal form or as a C-terminally truncated form led to inactive proteins. ..
- Liu S, Gao X, Gao N, Wang X, Fang X, Hu H, et al. Expression of type 1 corticotropin-releasing factor receptor in the guinea pig enteric nervous system. J Comp Neurol. 2005;481:284-98 pubmed..Actions on enteric neurons might underlie the neural mechanisms by which stress-related release of CRF in the periphery alters intestinal propulsive motor function, mucosal secretion, and barrier functions. ..
- Miller D, Roden A, Gamez J, Tazelaar H. Detection of C4d deposition in cardiac allografts: a comparative study of immunofluorescence and immunoperoxidase methods. Arch Pathol Lab Med. 2010;134:1679-84 pubmed publisher..88. Immunofluorescence and IP C4d staining methods are highly comparable and are both viable options for antibody-mediated rejection surveillance in transplant heart biopsies. ..
- Shang Y, Chong Z, Wang S, Maiese K. Prevention of ?-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL. Aging (Albany NY). 2012;4:187-201 pubmed..Our data may foster development of novel strategies to use cytoprotectants such as EPO for Alzheimer's disease and other degenerative disorders. ..
- Varshavsky A. Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis. Protein Sci. 2012;21:1634-61 pubmed publisher..Pharmacol Biochem Behav 1980;12:651-656). These results, which were never interpreted in connection to protein fragments or the function of sleep, may be accounted for by the FG hypothesis about molecular causation of sleep. ..
- Pandey V, Modak M. Biochemistry of terminal deoxynucleotidyltransferase. Identification and unity of ribo- and deoxyribonucleoside triphosphate binding site in terminal deoxynucleotidyltransferase. J Biol Chem. 1989;264:867-71 pubmed
- Zhang Y, Zhang P, West C. A linking function for the cellulose-binding protein SP85 in the spore coat of Dictyostelium discoideum. J Cell Sci. 1999;112 ( Pt 23):4367-77 pubmed
- Boules M, Fredrickson P, Richelson E. Current topics: brain penetrating neurotensin analog. Life Sci. 2003;73:2785-92 pubmed
- Ertekin Taner N, Allen M, Fadale D, Scanlin L, Younkin L, Petersen R, et al. Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. Hum Mutat. 2004;23:334-42 pubmed..007) in our family series. These results provide strong evidence for pathogenic variant(s) in the 276-kb region harboring IDE that influence intermediate AD phenotypes and risk for AD. ..
- Wilczynski A, Wang X, Bauzo R, Xiang Z, Shaw A, Millard W, et al. Structural characterization and pharmacology of a potent (Cys101-Cys119, Cys110-Cys117) bicyclic agouti-related protein (AGRP) melanocortin receptor antagonist. J Med Chem. 2004;47:5662-73 pubmed..J. Med. Chem. 2004, 47, 2194) in attempts to identify a "bioactive" conformation of the bicyclic hAGRP peptide and account for the 80-fold decreased ligand potency compared to hAGRP(87-132). ..
- Hofstetter H, Kovalovsky A, Shive C, Lehmann P, Forsthuber T. Neonatal induction of myelin-specific Th1/Th17 immunity does not result in experimental autoimmune encephalomyelitis and can protect against the disease in adulthood. J Neuroimmunol. 2007;187:20-30 pubmed..The results could provide a rationale for the presence of autoreactive T cells found in healthy human individuals without autoimmune disease. ..
- Lee Y, Tharp W, Maple R, Nair S, Permana P, Pratley R. Amyloid precursor protein expression is upregulated in adipocytes in obesity. Obesity (Silver Spring). 2008;16:1493-500 pubmed publisher..These data suggest a possible role for APP and/or Abeta in the development of obesity-related insulin resistance and adipose tissue inflammation. ..
- Armstrong L, Björkblom B, Hankenson K, Siadak A, Stiles C, Bornstein P. Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism. Mol Biol Cell. 2002;13:1893-905 pubmed
- Ott P, Dittrich M, Herzog B, Guerkov R, Gottlieb P, Putnam A, et al. T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading. J Clin Immunol. 2004;24:327-39 pubmed
- Abbott K, Archambault J, Xiao H, Nguyen B, Roeder R, Greenblatt J, et al. Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1. Biochemistry. 2005;44:2716-31 pubmed..In addition to increasing our understanding of the role of HIV-1 Tat in transcriptional regulation, this study defines a clear role for regions adjacent to the BRCT domain in promoting important protein-protein interactions. ..
- Eichler J, Brunner J, Wickner W. The protease-protected 30 kDa domain of SecA is largely inaccessible to the membrane lipid phase. EMBO J. 1997;16:2188-96 pubmed..We propose that the protease-inaccessible 30 kDa SecA domain is shielded from the fatty acyl membrane phase by membrane-spanning SecYEG helices and/or is largely exposed to the periplasm. ..
- Leahey T, Myers T, Gunstad J, Glickman E, Spitznagel M, Alexander T, et al. Abeta40 is associated with cognitive function, body fat and physical fitness in healthy older adults. Nutr Neurosci. 2007;10:205-9 pubmed..Findings indicate Abeta is associated with cognitive function, body fat and physical fitness in neurologically healthy older adults. Further work is needed to clarify possible mechanisms, particularly longitudinal studies. ..
- Fabbro S, Schaller K, Seeds N. Amyloid-beta levels are significantly reduced and spatial memory defects are rescued in a novel neuroserpin-deficient Alzheimer's disease transgenic mouse model. J Neurochem. 2011;118:928-38 pubmed publisher..These results support the concept that neuroserpin inhibition of tissue plasminogen activator plays an important role both in the accumulation of brain amyloid plaques and loss of cognitive abilities. ..
- Dong F, Qiu Y, Yi T, Touw I, Larner A. The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation. J Immunol. 2001;167:6447-52 pubmed
- Yin G, Liu W, An P, Li P, Ding I, Planelles V, et al. Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis. Mol Ther. 2002;5:547-54 pubmed..These data suggest a novel mechanism by which endostatin inhibits angiogenesis, and demonstrates the potential utility of anti-angiogenic gene therapy for treatment of inflammatory arthritis. ..
- Prechel M, Walenga J. The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update. Semin Thromb Hemost. 2008;34:86-96 pubmed publisher..Important drug-specific limitations and dosing and monitoring guidelines must be respected for patient safety. Issues still exist regarding the optimal clinical management of HIT. ..
- Laclair C, Ney D, MacLeod E, Etzel M. Purification and use of glycomacropeptide for nutritional management of phenylketonuria. J Food Sci. 2009;74:E199-206 pubmed publisher..Nutritionally complete GMP foods created with high purity GMP provide individuals with PKU with more options to manage PKU, which may lead to improved compliance and quality of life...
- Gold M, Fowler D, Means C, Pawson C, Stephany J, Langeberg L, et al. Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection. J Biol Chem. 2013;288:17111-21 pubmed publisher..We propose that this structure-directed evolution strategy might be generally applicable for the investigation of other protein interaction surfaces. ..
- Li D, Radulescu A, Shrestha R, Root M, Karger A, Killeen A, et al. Association of Biotin Ingestion With Performance of Hormone and Nonhormone Assays in Healthy Adults. JAMA. 2017;318:1150-1160 pubmed publisher..Excess biotin in blood due to supplemental biotin ingestion may affect biotin-streptavidin binding, leading to potential clinical misinterpretation. However, the degree of interference remains undefined in healthy adults...
- Molnar E, Seidler N, Jona I, Martonosi A. The binding of monoclonal and polyclonal antibodies to the Ca2(+)-ATPase of sarcoplasmic reticulum: effects on interactions between ATPase molecules. Biochim Biophys Acta. 1990;1023:147-67 pubmed
- Syu W, Kahan B, Kahan L. Epitope mapping of monoclonal antibodies to Escherichia coli ribosomal protein S3. J Protein Chem. 1990;9:159-67 pubmed..These epitope-mapped monoclonal antibodies are valuable probes for studying S3 structure in situ. ..
- Parchi P, Zou W, Wang W, Brown P, Capellari S, Ghetti B, et al. Genetic influence on the structural variations of the abnormal prion protein. Proc Natl Acad Sci U S A. 2000;97:10168-72 pubmed
- Ball L, Garland D, Crouch R, Schey K. Post-translational modifications of aquaporin 0 (AQP0) in the normal human lens: spatial and temporal occurrence. Biochemistry. 2004;43:9856-65 pubmed..Furthermore, the remarkably similar pattern and distribution of truncation products from lenses from three donors suggest specific temporal mechanisms for the modification of AQP0. ..
- Smith K, Boules M, Williams K, Fauq A, Richelson E. The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia. Behav Brain Res. 2011;224:344-9 pubmed publisher..Additionally, we suggest potential means by which NTS2 influences these NT69L-mediated behaviors. ..
- Burke K, Yates E, Legleiter J. Amyloid-forming proteins alter the local mechanical properties of lipid membranes. Biochemistry. 2013;52:808-17 pubmed publisher..These changes in bilayer mechanical properties upon exposure to amyloid-forming proteins may represent a common mechanism leading to membrane dysfunction in amyloid diseases. ..
- Bai L, Hecker J, Kerstetter A, Miller R. Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis. Neurosci Bull. 2013;29:239-50 pubmed publisher..These results suggested that adult NG2(+) cells represent a useful cell population for promoting neural repair in a variety of different conditions including demyelinating diseases such as MS. ..
- Wang K, Zhou X, Zhou Z, Mal N, Fan L, Zhang M, et al. Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injury. Arterioscler Thromb Vasc Biol. 2005;25:1584-9 pubmed
- Halatchev I, Cone R. Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice. Cell Metab. 2005;1:159-68 pubmed..Furthermore, peripheral administration of PYY3-36 causes conditioned taste aversion in mice. Thus, inhibition of food intake by PYY3-36 may result in part from induction of an aversive response. ..
- Exaire J, Butman S, Ebrahimi R, Kleiman N, Harrington R, Schweiger M, et al. Provisional glycoprotein IIb/IIIa blockade in a randomized investigation of bivalirudin versus heparin plus planned glycoprotein IIb/IIIa inhibition during percutaneous coronary intervention: predictors and outcome in the Randomized Evaluation in Per. Am Heart J. 2006;152:157-63 pubmed
- Shimko J, North J, Bruns A, Poirier M, Ottesen J. Preparation of fully synthetic histone H3 reveals that acetyl-lysine 56 facilitates protein binding within nucleosomes. J Mol Biol. 2011;408:187-204 pubmed publisher..Furthermore, we find that H3(K56Q) quantitatively imitates H3(K56ac) function. Together, these studies introduce powerful tools for the analysis of histone PTM functions. ..
- Su K, Savino C, Marracci G, Chaudhary P, Yu X, Morris B, et al. Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis. Eur J Neurosci. 2012;35:562-71 pubmed publisher..These results confirm the critical role of ROS-mediated mitochondrial dysfunction in the axonal loss that accompanies EAE, and identify p66 as a new pharmacologic target for MS neuroprotective therapeutics...
- McKoy A, Chen J, Schupbach T, Hecht M. A novel inhibitor of amyloid ? (A?) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease. J Biol Chem. 2012;287:38992-9000 pubmed publisher..Most importantly, treatment with D737 increases the life span and locomotive ability of flies in a Drosophila melanogaster model of Alzheimer disease. ..
- Xu Q, Yu L, Chitnis V, Chitnis P. Function and organization of photosystem I in a cyanobacterial mutant strain that lacks PsaF and PsaJ subunits. J Biol Chem. 1994;269:3205-11 pubmed..Therefore, PsaF and PsaJ subunits of photosystem I have dispensable accessory roles in the function and organization of the complex. ..
- Bai P, Peng Z. Cooperative folding of the isolated alpha-helical domain of hen egg-white lysozyme. J Mol Biol. 2001;314:321-9 pubmed
- Flowers L, Subramaniam P, Johnson H. A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells. Oncogene. 2005;24:2114-20 pubmed..These data describe a potentially important therapeutic that targets both constitutive and IL-6-induced STAT3 activation in human prostate cancer cell lines. ..
- Makkar R, Contreras M, Paintlia A, Smith B, Haq E, Singh I. Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix. Arch Biochem Biophys. 2006;451:128-40 pubmed..These observations indicate that L-BFE might help in oligomerization and possibly in the localization of catalase at the site of H2O2 production in the peroxisomal beta-oxidation pathway. ..
- Hartz A, Miller D, Bauer B. Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. Mol Pharmacol. 2010;77:715-23 pubmed publisher..This mechanism suggests a new therapeutic strategy in AD. ..
- Zhang L, Reilly J. De novo sequencing of tryptic peptides derived from Deinococcus radiodurans ribosomal proteins using 157 nm photodissociation MALDI TOF/TOF mass spectrometry. J Proteome Res. 2010;9:3025-34 pubmed publisher..In the present analysis, 52 peptide modifications were identified by de novo sequencing, most of which were not recognized by database searches. ..
- Damon S, Haugk K, Birnbaum R, Quinn L. Retrovirally mediated overexpression of insulin-like growth factor binding protein 4: evidence that insulin-like growth factor is required for skeletal muscle differentiation. J Cell Physiol. 1998;175:109-20 pubmed
- Pope C, Kim S, Marzo A, Masopust D, Williams K, Jiang J, et al. Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection. J Immunol. 2001;166:3402-9 pubmed..Overall, the results point to novel pathways of tissue-specific regulation of primary and memory antimicrobial CD8 T cell responses. ..
- Apetri A, Surewicz W. Kinetic intermediate in the folding of human prion protein. J Biol Chem. 2002;277:44589-92 pubmed..In addition to its role in the normal prion protein folding, this intermediate likely represents a crucial monomeric precursor of the pathogenic PrP(Sc) isoform. ..
- Ertekin Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, et al. Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Hum Mol Genet. 2005;14:447-60 pubmed..PLAU_1 is a plausible pathogenic mutation that could act by increasing Abeta42, but additional biological experiments are required to show this definitively. ..
- Imhof D, Wavreille A, May A, Zacharias M, Tridandapani S, Pei D. Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position. J Biol Chem. 2006;281:20271-82 pubmed..Examination of pY motifs from known SHP-1 and SHP-2-binding proteins shows that many of the pY motifs contain a hydrophobic or positively charged residue(s) at the pY+4 and pY+5 positions. ..
- Drake M, McCready L, Hoey K, Atkinson E, Khosla S. Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women. J Clin Endocrinol Metab. 2010;95:5063-8 pubmed publisher..161 and 0.266 for comparison of percent changes between groups). This direct interventional study demonstrates that FSH does not regulate bone resorption in postmenopausal women. ..
- Sides C, Liyanage R, Lay J, Philominathan S, Matsushita O, Sakon J. Probing the 3-D structure, dynamics, and stability of bacterial collagenase collagen binding domain (apo- versus holo-) by limited proteolysis MALDI-TOF MS. J Am Soc Mass Spectrom. 2012;23:505-19 pubmed publisher..Cobalt binding has a regional effect on the solution phase stability of CBD, as limited proteolysis data implies the capture of an intermediate-CBD solution structure when cobalt is bound...
- Kiptoo P, Büyüktimkin B, Badawi A, Stewart J, Ridwan R, Siahaan T. Controlling immune response and demyelination using highly potent bifunctional peptide inhibitors in the suppression of experimental autoimmune encephalomyelitis. Clin Exp Immunol. 2013;172:23-36 pubmed publisher..Also, we observed significantly less demyelination in PLP-cIBR-treated mice compared to the control, further indicating that PLP-cIBR promoted protection against demyelination. ..
- Thomas E, Connelly R, Pennathur S, Dubrovsky L, Haffar O, Bukrinsky M. Anti-idiotypic antibody to the V3 domain of gp120 binds to vimentin: a possible role of intermediate filaments in the early steps of HIV-1 infection cycle. Viral Immunol. 1996;9:73-87 pubmed..These data suggest that vimentin may participate in the early steps of HIV-1 replication, perhaps during the uptake of HIV-1 preintegration complexes into the nuclear compartment. ..
- Wicher K, Wicher V, Abbruscato F, Baughn R. Treponema pallidum subsp. pertenue displays pathogenic properties different from those of T. pallidum subsp. pallidum. Infect Immun. 2000;68:3219-25 pubmed..These findings stress the dermotropic rather than the organotropic character of yaws and provide further evidence of distinctive biological and pathological differences between yaws and venereal syphilis. ..
- Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, et al. Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron. 2002;33:677-88 pubmed..Thus, mitochondrial dysfunction in DS may lead to intracellular deposition of Abeta42, reduced levels of AbetaPPs, and a chronic state of increased neuronal vulnerability. ..
- Muresan Z, Muresan V. A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment. Hum Mol Genet. 2004;13:475-88 pubmed..These results suggest that phosphorylated Cgamma accumulates at the SFC. Thus, APP may play a role in pre-mRNA splicing, and Fe65 and APP phosphorylation may regulate this function. ..
- Wang X, Kim S, Ablonczy Z, Crouch R, Knapp D. Probing rhodopsin-transducin interactions by surface modification and mass spectrometry. Biochemistry. 2004;43:11153-62 pubmed..In addition, we show evidence of interaction between the end of the C-terminal tail of rhodopsin and G(t)alpha in the unactivated state of rhodopsin. ..
- Peterson J, Sheibani N, David G, Garcia Pardo A, Peters D. Heparin II domain of fibronectin uses alpha4beta1 integrin to control focal adhesion and stress fiber formation, independent of syndecan-4. J Biol Chem. 2005;280:6915-22 pubmed
- Bruijnzeel A, Prado M, Isaac S. Corticotropin-releasing factor-1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse. Biol Psychiatry. 2009;66:110-7 pubmed publisher..These studies indicate that CRF(1) receptors but not CRF(2) receptors play an important role in the anhedonic-state associated with acute nicotine withdrawal and stress-induced reinstatement of nicotine-seeking. ..