Experts and Doctors on peptide fragments in United States

Summary

Locale: United States
Topic: peptide fragments

Top Publications

  1. Song J, Kandasamy K, Zemskova M, Lin Y, Kraft A. The BH3 mimetic ABT-737 induces cancer cell senescence. Cancer Res. 2011;71:506-15 pubmed publisher
    ..Thus, in multiple cancer types in which ABT-737 is incapable of causing cell death, ABT-737 may have additional cellular activities that make its use as an anticancer agent highly attractive. ..
  2. Rowe B, Saylor D, Speth R, Absher D. Angiotensin-(1-7) binding at angiotensin II receptors in the rat brain. Regul Pept. 1995;56:139-46 pubmed
    ..For biological responses where Ang-(1-7) is reported to be equipotent with AII, it is unlikely that these actions are mediated by the widely distributed AT1 or AT2 receptor subtypes which recognize 125I Sar1 Ile8 AII. ..
  3. Nie Y, Li H, Bula C, Liu X. Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization. Mol Cell Biol. 2000;20:741-8 pubmed
    ..Together, these results suggest a detailed mechanism by which c-Abl activates p53 DNA-binding via the carboxyl-terminal regulatory domain and tetramerization. ..
  4. Cao O, Dobrzynski E, Wang L, Nayak S, Mingle B, Terhorst C, et al. Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer. Blood. 2007;110:1132-40 pubmed
    ..Our study reveals a crucial role of CD4(+)CD25(+) T(regs) in preventing immune responses to the transgene product in gene transfer. ..
  5. Liu J, Lin F, Strainic M, An F, Miller R, Altuntas C, et al. IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J Immunol. 2008;180:5882-9 pubmed
  6. O Connell R, Kahn D, Gibson W, Round J, Scholz R, Chaudhuri A, et al. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity. 2010;33:607-19 pubmed publisher
    ..Our study shows that one aspect of miR-155 function is the promotion of T cell-dependent tissue inflammation, suggesting that miR-155 might be a promising therapeutic target for the treatment of autoimmune disorders. ..
  7. Triozzi P, Aldrich W, Ponnazhagan S. Regulation of the activity of an adeno-associated virus vector cancer vaccine administered with synthetic Toll-like receptor agonists. Vaccine. 2010;28:7837-43 pubmed publisher
    ..Suppressor mechanisms, including those mediated by myeloid cells, may negatively regulate the antitumor immune response. ..
  8. De Beer M, de Beer F, Beach C, Carreras I, Sipe J. Mouse serum amyloid A protein. Complete amino acid sequence and mRNA analysis of a new isoform. Biochem J. 1992;283 ( Pt 3):673-8 pubmed
    ..We propose that, when analysing a multigene family such as SAA, thorough analysis at the protein level should complement molecular-biological approaches where the use of a too-limited repertoire of probes can obscure complexities. ..
  9. Rutledge T, Whiteheart S. SNAP-23 is a target for calpain cleavage in activated platelets. J Biol Chem. 2002;277:37009-15 pubmed
    ..This is consistent with the ultrastructural morphology of calpeptin-treated platelets after activation. ..

More Information

Publications203 found, 100 shown here

  1. Nguyen B, Chen H, Kobor M, Greenblatt J, Legault P, Omichinski J. Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB. Biochemistry. 2003;42:1460-9 pubmed
    ..These results provide new information about the recognition of acidic-rich activation domains involved in transcriptional regulation, and provide insights into how TFIIF and TFIIB regulate the FCP1 phosphatase activity in vivo. ..
  2. Wegmann K, Bouwer H, Gregory C, Whitham R, Hinrichs D. Targeting T cells responsive to the priming epitope prevent the relapsing phase of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2013;260:74-81 pubmed publisher
    ..Our studies show that the peptide-octamers, which target the T cells stimulated by the priming encephalitogen, but not other candidate encephalitogens, prevent rEAE. ..
  3. HIRBAWI J, Bialkowska K, Bledzka K, Liu J, Fukuda K, Qin J, et al. The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation. J Biol Chem. 2017;292:14258-14269 pubmed publisher
    ..Our findings indicate that the extreme C terminus of K2 is essential for integrin co-activation and highlight the importance of an atypical architecture of the K2 FERM domain in regulating integrin activation. ..
  4. Rowley R, Burkhardt A, Chao H, Matsueda G, Bolen J. Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation. J Biol Chem. 1995;270:11590-4 pubmed
  5. Yoder Hill J, Pause A, Sonenberg N, Merrick W. The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A. J Biol Chem. 1993;268:5566-73 pubmed
  6. Nekrasova T, Shive C, Gao Y, Kawamura K, Guardia R, Landreth G, et al. ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis. J Immunol. 2005;175:2374-80 pubmed
    ..Collectively, the data show that ERK1 is not critical for the function of peripheral T cells in the response to self and foreign Ags and in T cell-mediated autoimmunity, and suggest that its loss can be compensated by ERK2. ..
  7. Sirohi S, Aldrich J, Walker B. Species differences in the effects of the ?-opioid receptor antagonist zyklophin. Alcohol. 2016;51:43-9 pubmed publisher
    ..These results identify species differences in zyklophin efficacy that, given the rising interest in the development of short-duration KOR antagonists, should provide valuable information for therapeutic development efforts. ..
  8. Towndrow K, Jia Z, Lo H, Person M, Monks T, Lau S. 11-Deoxy,16,16-dimethyl prostaglandin E2 induces specific proteins in association with its ability to protect against oxidative stress. Chem Res Toxicol. 2003;16:312-9 pubmed
    ..The present studies provide insights into potential downstream targets of PG signaling. ..
  9. DiNovo A, Schey K, Vachon W, McGuffie E, Olson J, Vincent T. ADP-ribosylation of cyclophilin A by Pseudomonas aeruginosa exoenzyme S. Biochemistry. 2006;45:4664-73 pubmed
    ..Our results support that ExoS ADP-ribosylates and affects the function of the cytosolic protein, CpA, with the predominant functional effect relating to interference of CpA-cellular protein interactions. ..
  10. Kim J, Miller V, Levites Y, West K, Zwizinski C, Moore B, et al. BRI2 (ITM2b) inhibits Abeta deposition in vivo. J Neurosci. 2008;28:6030-6 pubmed publisher
    ..These studies demonstrate that BRI2 is a novel mediator of Abeta deposition in vivo. ..
  11. Nagase H, Brew K. Amino acid sequence of a 32-residue region around the thiol ester site in duck ovostatin. FEBS Lett. 1987;222:83-8 pubmed
    ..The results indicate that ovostatin is a close relative to plasma alpha-macroglobulins and may share a common ancestor with C3 and C4. ..
  12. Rubinstein M, Kadima A, Salem M, Nguyen C, Gillanders W, Cole D. Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells. J Immunol. 2002;169:4928-35 pubmed
    ..These studies show for the first time that IL-15 is capable of augmenting the primary CD8(+) T cell response to vaccination and contribute to the basis for future experiments exploring the clinical role of IL-15. ..
  13. Klase Z, Donio M, Blauvelt A, Marx P, Jeang K, Smith S. A peptide-loaded dendritic cell based cytotoxic T-lymphocyte (CTL) vaccination strategy using peptides that span SIV Tat, Rev, and Env overlapping reading frames. Retrovirology. 2006;3:1 pubmed publisher
    ..However, conclusive in vivo control of a challenge inoculation of SIVmac239 was not observed suggesting that CTL epitopes within densely overlapping reading frames are also subject to escape mutations...
  14. Aikman J, O Steen B, Silver X, Torres R, Boslaugh S, Blackband S, et al. Alpha-II-spectrin after controlled cortical impact in the immature rat brain. Dev Neurosci. 2006;28:457-65 pubmed
    ..Distinct proteolytic products resulting from the degradation of the cytoskeletal protein alpha-II-spectrin by calpain and caspase 3 were readily detectable in cortical brain parenchyma and cerebrospinal fluid after TBI in immature rats. ..
  15. Che M, Boja E, Yoon H, Gruschus J, Jaffe H, Stauffer S, et al. Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains. Cell Signal. 2005;17:1276-88 pubmed
  16. Gloor J, Stegall M. ABO incompatible kidney transplantation. Curr Opin Nephrol Hypertens. 2007;16:529-34 pubmed
    ..ABO incompatible kidney transplantation is an effective therapy, and will become more widely implemented in the future. ..
  17. Jenkins C, Cardona D, Bowers J, Oliai B, Allan R, Normann S. The utility of C4d, C9, and troponin T immunohistochemistry in acute myocardial infarction. Arch Pathol Lab Med. 2010;134:256-63 pubmed publisher
    ..Patchy loss of Troponin T in some cases of histologically normal myocardium limited its usefulness as a sole marker of infarction. ..
  18. Moore K, Bryant Z, Ghatnekar G, Singh U, Gourdie R, Potts J. A synthetic connexin 43 mimetic peptide augments corneal wound healing. Exp Eye Res. 2013;115:178-88 pubmed publisher
    ..These results suggest ?CT1, when applied in a sustained release system, acts as a beneficial wound healing treatment. ..
  19. Polfer N, Bohrer B, Plasencia M, Paizs B, Clemmer D. On the dynamics of fragment isomerization in collision-induced dissociation of peptides. J Phys Chem A. 2008;112:1286-93 pubmed publisher
    ..It is demonstrated here that cyclic and linear a4 structures can interconvert freely as a result of collisional activation, implying that isomerization takes place prior to dissociation. ..
  20. Carlson J, Brumme Z, Rousseau C, Brumme C, Matthews P, Kadie C, et al. Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag. PLoS Comput Biol. 2008;4:e1000225 pubmed publisher
    ..Phylogenetic dependency networks represent a major step toward systematically expanding our understanding of CTL escape to diverse populations and whole viral genes. ..
  21. Mondello S, Robicsek S, Gabrielli A, Brophy G, Papa L, Tepas J, et al. ?II-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients. J Neurotrauma. 2010;27:1203-13 pubmed publisher
    ..The time course of SBDPs in nonsurvivors also differed from that of survivors. These results suggest that CSF SBDP levels can predict injury severity and mortality after severe TBI, and can be useful complements to clinical assessment. ..
  22. Plumb M, Scibek J, Barber T, Dunlap R, Platteborze P, Sodetz J. Chimeric and truncated forms of human complement protein C8 alpha reveal binding sites for C8 beta and C8 gamma within the membrane attack complex/perforin region. Biochemistry. 1999;38:8478-84 pubmed
    ..They also suggest that the N-terminal modules in C8 alpha are important for C9 binding and/or expression of C8 activity. ..
  23. Deucher A, Nagpal S, Chandraratna R, Di Sepio D, Robinson N, Dashti S, et al. The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity. Int J Oncol. 2000;17:1195-203 pubmed
    ..This suggests that the c-terminal hydrophobic domain has an important role in determining the intracellular localization of TIG3. In addition, GFP-TIG31-164 retains the ability to inhibit cell function, while GFP-TIG31-134 is inactive. ..
  24. Ma Z, Chow K, Csuhai E, Hersh L. The use of proteolysis to study the structure of nardilysin. Arch Biochem Biophys. 2002;401:198-204 pubmed
    ..Treatment of nardilysin(V8) with trypsin generated primarily the 92 kDa form which was inactive. Attempts to express nardilysin as a 105 kDa truncated N-terminal form or as a C-terminally truncated form led to inactive proteins. ..
  25. Liu S, Gao X, Gao N, Wang X, Fang X, Hu H, et al. Expression of type 1 corticotropin-releasing factor receptor in the guinea pig enteric nervous system. J Comp Neurol. 2005;481:284-98 pubmed
    ..Actions on enteric neurons might underlie the neural mechanisms by which stress-related release of CRF in the periphery alters intestinal propulsive motor function, mucosal secretion, and barrier functions. ..
  26. Hahn T, Bradley Dunlop D, Hurley L, Von Hoff D, Gately S, Mary D, et al. The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer. BMC Cancer. 2011;11:471 pubmed publisher
  27. Schwacke J, Spainhour J, Ierardi J, Chaves J, Arthur J, Janech M, et al. Network modeling reveals steps in angiotensin peptide processing. Hypertension. 2013;61:690-700 pubmed publisher
  28. Miller D, Roden A, Gamez J, Tazelaar H. Detection of C4d deposition in cardiac allografts: a comparative study of immunofluorescence and immunoperoxidase methods. Arch Pathol Lab Med. 2010;134:1679-84 pubmed publisher
    ..88. Immunofluorescence and IP C4d staining methods are highly comparable and are both viable options for antibody-mediated rejection surveillance in transplant heart biopsies. ..
  29. Shang Y, Chong Z, Wang S, Maiese K. Prevention of ?-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL. Aging (Albany NY). 2012;4:187-201 pubmed
    ..Our data may foster development of novel strategies to use cytoprotectants such as EPO for Alzheimer's disease and other degenerative disorders. ..
  30. Varshavsky A. Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis. Protein Sci. 2012;21:1634-61 pubmed publisher
    ..Pharmacol Biochem Behav 1980;12:651-656). These results, which were never interpreted in connection to protein fragments or the function of sleep, may be accounted for by the FG hypothesis about molecular causation of sleep. ..
  31. Rouse M, Nagarkatti M, Nagarkatti P. The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis. Immunobiology. 2013;218:674-82 pubmed publisher
  32. Pandey V, Modak M. Biochemistry of terminal deoxynucleotidyltransferase. Identification and unity of ribo- and deoxyribonucleoside triphosphate binding site in terminal deoxynucleotidyltransferase. J Biol Chem. 1989;264:867-71 pubmed
  33. Zhang Y, Zhang P, West C. A linking function for the cellulose-binding protein SP85 in the spore coat of Dictyostelium discoideum. J Cell Sci. 1999;112 ( Pt 23):4367-77 pubmed
  34. Boules M, Fredrickson P, Richelson E. Current topics: brain penetrating neurotensin analog. Life Sci. 2003;73:2785-92 pubmed
  35. Ertekin Taner N, Allen M, Fadale D, Scanlin L, Younkin L, Petersen R, et al. Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. Hum Mutat. 2004;23:334-42 pubmed
    ..007) in our family series. These results provide strong evidence for pathogenic variant(s) in the 276-kb region harboring IDE that influence intermediate AD phenotypes and risk for AD. ..
  36. Wilczynski A, Wang X, Bauzo R, Xiang Z, Shaw A, Millard W, et al. Structural characterization and pharmacology of a potent (Cys101-Cys119, Cys110-Cys117) bicyclic agouti-related protein (AGRP) melanocortin receptor antagonist. J Med Chem. 2004;47:5662-73 pubmed
    ..J. Med. Chem. 2004, 47, 2194) in attempts to identify a "bioactive" conformation of the bicyclic hAGRP peptide and account for the 80-fold decreased ligand potency compared to hAGRP(87-132). ..
  37. Hofstetter H, Kovalovsky A, Shive C, Lehmann P, Forsthuber T. Neonatal induction of myelin-specific Th1/Th17 immunity does not result in experimental autoimmune encephalomyelitis and can protect against the disease in adulthood. J Neuroimmunol. 2007;187:20-30 pubmed
    ..The results could provide a rationale for the presence of autoreactive T cells found in healthy human individuals without autoimmune disease. ..
  38. Lee Y, Tharp W, Maple R, Nair S, Permana P, Pratley R. Amyloid precursor protein expression is upregulated in adipocytes in obesity. Obesity (Silver Spring). 2008;16:1493-500 pubmed publisher
    ..These data suggest a possible role for APP and/or Abeta in the development of obesity-related insulin resistance and adipose tissue inflammation. ..
  39. Wagner J, Evans T, Chen J, Zhu H, Houben E, Bitter W, et al. Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis. J Struct Biol. 2013;184:115-28 pubmed publisher
  40. Armstrong L, Björkblom B, Hankenson K, Siadak A, Stiles C, Bornstein P. Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism. Mol Biol Cell. 2002;13:1893-905 pubmed
  41. Ott P, Dittrich M, Herzog B, Guerkov R, Gottlieb P, Putnam A, et al. T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading. J Clin Immunol. 2004;24:327-39 pubmed
  42. Abbott K, Archambault J, Xiao H, Nguyen B, Roeder R, Greenblatt J, et al. Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1. Biochemistry. 2005;44:2716-31 pubmed
    ..In addition to increasing our understanding of the role of HIV-1 Tat in transcriptional regulation, this study defines a clear role for regions adjacent to the BRCT domain in promoting important protein-protein interactions. ..
  43. Brown A, Lemkul J, Schaum N, Bevan D. Simulations of monomeric amyloid ?-peptide (1-40) with varying solution conditions and oxidation state of Met35: implications for aggregation. Arch Biochem Biophys. 2014;545:44-52 pubmed publisher
  44. Eichler J, Brunner J, Wickner W. The protease-protected 30 kDa domain of SecA is largely inaccessible to the membrane lipid phase. EMBO J. 1997;16:2188-96 pubmed
    ..We propose that the protease-inaccessible 30 kDa SecA domain is shielded from the fatty acyl membrane phase by membrane-spanning SecYEG helices and/or is largely exposed to the periplasm. ..
  45. Leahey T, Myers T, Gunstad J, Glickman E, Spitznagel M, Alexander T, et al. Abeta40 is associated with cognitive function, body fat and physical fitness in healthy older adults. Nutr Neurosci. 2007;10:205-9 pubmed
    ..Findings indicate Abeta is associated with cognitive function, body fat and physical fitness in neurologically healthy older adults. Further work is needed to clarify possible mechanisms, particularly longitudinal studies. ..
  46. Fabbro S, Schaller K, Seeds N. Amyloid-beta levels are significantly reduced and spatial memory defects are rescued in a novel neuroserpin-deficient Alzheimer's disease transgenic mouse model. J Neurochem. 2011;118:928-38 pubmed publisher
    ..These results support the concept that neuroserpin inhibition of tissue plasminogen activator plays an important role both in the accumulation of brain amyloid plaques and loss of cognitive abilities. ..
  47. Dong F, Qiu Y, Yi T, Touw I, Larner A. The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation. J Immunol. 2001;167:6447-52 pubmed
  48. Yin G, Liu W, An P, Li P, Ding I, Planelles V, et al. Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis. Mol Ther. 2002;5:547-54 pubmed
    ..These data suggest a novel mechanism by which endostatin inhibits angiogenesis, and demonstrates the potential utility of anti-angiogenic gene therapy for treatment of inflammatory arthritis. ..
  49. Prechel M, Walenga J. The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update. Semin Thromb Hemost. 2008;34:86-96 pubmed publisher
    ..Important drug-specific limitations and dosing and monitoring guidelines must be respected for patient safety. Issues still exist regarding the optimal clinical management of HIT. ..
  50. Laclair C, Ney D, MacLeod E, Etzel M. Purification and use of glycomacropeptide for nutritional management of phenylketonuria. J Food Sci. 2009;74:E199-206 pubmed publisher
    ..Nutritionally complete GMP foods created with high purity GMP provide individuals with PKU with more options to manage PKU, which may lead to improved compliance and quality of life...
  51. Gold M, Fowler D, Means C, Pawson C, Stephany J, Langeberg L, et al. Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection. J Biol Chem. 2013;288:17111-21 pubmed publisher
    ..We propose that this structure-directed evolution strategy might be generally applicable for the investigation of other protein interaction surfaces. ..
  52. Li D, Radulescu A, Shrestha R, Root M, Karger A, Killeen A, et al. Association of Biotin Ingestion With Performance of Hormone and Nonhormone Assays in Healthy Adults. JAMA. 2017;318:1150-1160 pubmed publisher
    ..Excess biotin in blood due to supplemental biotin ingestion may affect biotin-streptavidin binding, leading to potential clinical misinterpretation. However, the degree of interference remains undefined in healthy adults...
  53. Molnar E, Seidler N, Jona I, Martonosi A. The binding of monoclonal and polyclonal antibodies to the Ca2(+)-ATPase of sarcoplasmic reticulum: effects on interactions between ATPase molecules. Biochim Biophys Acta. 1990;1023:147-67 pubmed
  54. Syu W, Kahan B, Kahan L. Epitope mapping of monoclonal antibodies to Escherichia coli ribosomal protein S3. J Protein Chem. 1990;9:159-67 pubmed
    ..These epitope-mapped monoclonal antibodies are valuable probes for studying S3 structure in situ. ..
  55. Parchi P, Zou W, Wang W, Brown P, Capellari S, Ghetti B, et al. Genetic influence on the structural variations of the abnormal prion protein. Proc Natl Acad Sci U S A. 2000;97:10168-72 pubmed
  56. Ball L, Garland D, Crouch R, Schey K. Post-translational modifications of aquaporin 0 (AQP0) in the normal human lens: spatial and temporal occurrence. Biochemistry. 2004;43:9856-65 pubmed
    ..Furthermore, the remarkably similar pattern and distribution of truncation products from lenses from three donors suggest specific temporal mechanisms for the modification of AQP0. ..
  57. Smith K, Boules M, Williams K, Fauq A, Richelson E. The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia. Behav Brain Res. 2011;224:344-9 pubmed publisher
    ..Additionally, we suggest potential means by which NTS2 influences these NT69L-mediated behaviors. ..
  58. McManus M, Murphy M, Franklin J. The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2011;31:15703-15 pubmed publisher
  59. Burke K, Yates E, Legleiter J. Amyloid-forming proteins alter the local mechanical properties of lipid membranes. Biochemistry. 2013;52:808-17 pubmed publisher
    ..These changes in bilayer mechanical properties upon exposure to amyloid-forming proteins may represent a common mechanism leading to membrane dysfunction in amyloid diseases. ..
  60. Bai L, Hecker J, Kerstetter A, Miller R. Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis. Neurosci Bull. 2013;29:239-50 pubmed publisher
    ..These results suggested that adult NG2(+) cells represent a useful cell population for promoting neural repair in a variety of different conditions including demyelinating diseases such as MS. ..
  61. Wang K, Zhou X, Zhou Z, Mal N, Fan L, Zhang M, et al. Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injury. Arterioscler Thromb Vasc Biol. 2005;25:1584-9 pubmed
  62. Halatchev I, Cone R. Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice. Cell Metab. 2005;1:159-68 pubmed
    ..Furthermore, peripheral administration of PYY3-36 causes conditioned taste aversion in mice. Thus, inhibition of food intake by PYY3-36 may result in part from induction of an aversive response. ..
  63. Exaire J, Butman S, Ebrahimi R, Kleiman N, Harrington R, Schweiger M, et al. Provisional glycoprotein IIb/IIIa blockade in a randomized investigation of bivalirudin versus heparin plus planned glycoprotein IIb/IIIa inhibition during percutaneous coronary intervention: predictors and outcome in the Randomized Evaluation in Per. Am Heart J. 2006;152:157-63 pubmed
  64. Shimko J, North J, Bruns A, Poirier M, Ottesen J. Preparation of fully synthetic histone H3 reveals that acetyl-lysine 56 facilitates protein binding within nucleosomes. J Mol Biol. 2011;408:187-204 pubmed publisher
    ..Furthermore, we find that H3(K56Q) quantitatively imitates H3(K56ac) function. Together, these studies introduce powerful tools for the analysis of histone PTM functions. ..
  65. Su K, Savino C, Marracci G, Chaudhary P, Yu X, Morris B, et al. Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis. Eur J Neurosci. 2012;35:562-71 pubmed publisher
    ..These results confirm the critical role of ROS-mediated mitochondrial dysfunction in the axonal loss that accompanies EAE, and identify p66 as a new pharmacologic target for MS neuroprotective therapeutics...
  66. McKoy A, Chen J, Schupbach T, Hecht M. A novel inhibitor of amyloid ? (A?) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease. J Biol Chem. 2012;287:38992-9000 pubmed publisher
    ..Most importantly, treatment with D737 increases the life span and locomotive ability of flies in a Drosophila melanogaster model of Alzheimer disease. ..
  67. Hebert A, Dittenhafer Reed K, Yu W, Bailey D, Selen E, Boersma M, et al. Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell. 2013;49:186-99 pubmed publisher
  68. Xu Q, Yu L, Chitnis V, Chitnis P. Function and organization of photosystem I in a cyanobacterial mutant strain that lacks PsaF and PsaJ subunits. J Biol Chem. 1994;269:3205-11 pubmed
    ..Therefore, PsaF and PsaJ subunits of photosystem I have dispensable accessory roles in the function and organization of the complex. ..
  69. Bai P, Peng Z. Cooperative folding of the isolated alpha-helical domain of hen egg-white lysozyme. J Mol Biol. 2001;314:321-9 pubmed
  70. Flowers L, Subramaniam P, Johnson H. A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells. Oncogene. 2005;24:2114-20 pubmed
    ..These data describe a potentially important therapeutic that targets both constitutive and IL-6-induced STAT3 activation in human prostate cancer cell lines. ..
  71. Makkar R, Contreras M, Paintlia A, Smith B, Haq E, Singh I. Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix. Arch Biochem Biophys. 2006;451:128-40 pubmed
    ..These observations indicate that L-BFE might help in oligomerization and possibly in the localization of catalase at the site of H2O2 production in the peroxisomal beta-oxidation pathway. ..
  72. Hartz A, Miller D, Bauer B. Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. Mol Pharmacol. 2010;77:715-23 pubmed publisher
    ..This mechanism suggests a new therapeutic strategy in AD. ..
  73. Vernon R, Chong P, Lin H, Yang Z, Zhou Q, Aleksandrov A, et al. Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations. J Biol Chem. 2017;292:14147-14164 pubmed publisher
  74. Zhang L, Reilly J. De novo sequencing of tryptic peptides derived from Deinococcus radiodurans ribosomal proteins using 157 nm photodissociation MALDI TOF/TOF mass spectrometry. J Proteome Res. 2010;9:3025-34 pubmed publisher
    ..In the present analysis, 52 peptide modifications were identified by de novo sequencing, most of which were not recognized by database searches. ..
  75. Walker K, Nan R, Wright D, Gor J, Bishop A, Makhatadze G, et al. Non-linearity of the collagen triple helix in solution and implications for collagen function. Biochem J. 2017;474:2203-2217 pubmed publisher
  76. Damon S, Haugk K, Birnbaum R, Quinn L. Retrovirally mediated overexpression of insulin-like growth factor binding protein 4: evidence that insulin-like growth factor is required for skeletal muscle differentiation. J Cell Physiol. 1998;175:109-20 pubmed
  77. Beauvais D, Rapraeger A. Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation. J Cell Sci. 2010;123:3796-807 pubmed publisher
  78. Bansal N, Zhang M, Bhaskar A, Itotia P, Lee E, Shlyakhtenko L, et al. Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. Biochemistry. 2013;52:520-36 pubmed publisher
  79. Pope C, Kim S, Marzo A, Masopust D, Williams K, Jiang J, et al. Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection. J Immunol. 2001;166:3402-9 pubmed
    ..Overall, the results point to novel pathways of tissue-specific regulation of primary and memory antimicrobial CD8 T cell responses. ..
  80. Apetri A, Surewicz W. Kinetic intermediate in the folding of human prion protein. J Biol Chem. 2002;277:44589-92 pubmed
    ..In addition to its role in the normal prion protein folding, this intermediate likely represents a crucial monomeric precursor of the pathogenic PrP(Sc) isoform. ..
  81. Ertekin Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, et al. Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Hum Mol Genet. 2005;14:447-60 pubmed
    ..PLAU_1 is a plausible pathogenic mutation that could act by increasing Abeta42, but additional biological experiments are required to show this definitively. ..
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