Genomes and Genes
Experts and Doctors on peptide fragments in United States
Locale: United States
Topic: peptide fragments
Publications616 found, 100 shown here
- Hearst S, Walker L, Shao Q, Lopez M, Raucher D, Vig P. The design and delivery of a thermally responsive peptide to inhibit S100B-mediated neurodegeneration. Neuroscience. 2011;197:369-80 pubmed publisher..Overall, our data suggest that thermal targeting of ELP-based therapeutic peptides to the cerebellum is a novel treatment strategy for cerebellar neurodegenerative disorders. ..
- Acosta A, Hurtado M, Gorbatyuk O, La Sala M, Duncan D, Aslanidi G, et al. Salivary PYY: a putative bypass to satiety. PLoS ONE. 2011;6:e26137 pubmed publisher..Thus this study provides evidence for new functions of the previously characterized gut peptide PYY(3-36) suggesting a potential simple and efficient alternative therapeutic approach for the treatment of obesity...
- Wang L, Wagner L, Alzayady K, Yule D. Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity. J Biol Chem. 2017;292:11714-11726 pubmed publisher..Our work suggests that proteolysis of IP3R1 may represent a novel form of modulation of IP3R1 channel function and increases the repertoire of Ca2+ signals achievable through this channel. ..
- Eisenstein R, Tuazon P, Schalinske K, Anderson S, Traugh J. Iron-responsive element-binding protein. Phosphorylation by protein kinase C. J Biol Chem. 1993;268:27363-70 pubmed..Taken together, our studies begin to define a novel mechanism by which hormones, growth factors, and other agents may regulate cellular iron utilization through specific phosphoregulation of the IRE-BP. ..
- Robinson N, Eckert R. Identification of transglutaminase-reactive residues in S100A11. J Biol Chem. 1998;273:2721-8 pubmed
- Tuske S, Singh K, Kaushik N, Modak M. The J-helix of Escherichia coli DNA polymerase I (Klenow fragment) regulates polymerase and 3'- 5'-exonuclease functions. J Biol Chem. 2000;275:23759-68 pubmed
- Johnson B, Chadli A, Felts S, Bouhouche I, Catelli M, Toft D. Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains. J Biol Chem. 2000;275:32499-507 pubmed..Hsp90 and the co-chaperone, Hop, enhance this process. This hsp90 activity was only observed using full-length hsp90 indicating that the cooperation of multiple functional domains is essential for active, chaperone-mediated folding. ..
- Morillas M, Vanik D, Surewicz W. On the mechanism of alpha-helix to beta-sheet transition in the recombinant prion protein. Biochemistry. 2001;40:6982-7 pubmed..The present data strongly suggest that partially unfolded intermediates may be involved in the transition of the monomeric recombinant prion protein into the oligomeric scrapie-like form. ..
- Wu J, Wade W, Taylor R. Evaluation of cholera vaccines formulated with toxin-coregulated pilin peptide plus polymer adjuvant in mice. Infect Immun. 2001;69:7695-702 pubmed..These results indicate that specific regions of TcpA, including those delineated by the peptides used in this study, have the potential to be incorporated into an effective defined subunit vaccine for cholera. ..
- Peters R, Carter O, Zhang Y, Matthews B, Croteau R. Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations. Biochemistry. 2003;42:2700-7 pubmed..Thus, the two cyclization sites of abietadiene synthase cannot be dissected into catalytically distinct domains, and, therefore, abietadiene synthase is unlikely to have arisen by fusion of two previously independent genes. ..
- Nogami K, Freas J, Manithody C, Wakabayashi H, Rezaie A, Fay P. Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain. J Biol Chem. 2004;279:33104-13 pubmed..Furthermore, factor Xa but not factor X interacts with high affinity at this site via residues contained within the heparin-binding exosite of the proteinase. ..
- Edling A, Nanavati T, Johnson J, Tuohy V. Human and murine lymphocyte neurotrophin expression is confined to B cells. J Neurosci Res. 2004;77:709-17 pubmed
- Downing M, Brady K, Caprara M. A C-terminal fragment of an intron-encoded maturase is sufficient for promoting group I intron splicing. RNA. 2005;11:437-46 pubmed..This fragment of I-AniI represents the smallest group I intron splicing cofactor described to date. ..
- Nath N, Giri S, Prasad R, Salem M, Singh A, Singh I. 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis. J Immunol. 2005;175:566-74 pubmed..Together, these findings show for the first time that AICAR is a novel immunomodulator with promising beneficial effects for the treatment of multiple sclerosis and other Th1-mediated inflammatory diseases. ..
- Garrett J, Rawale S, Allen S, Phillips G, Forni G, Morris J, et al. Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu. J Immunol. 2007;178:7120-31 pubmed..These results suggest the peptide B cell immunogen is appropriate as a vaccine for HER-2-overexpressing cancers because the resulting Abs show analogous biological properties to trastuzumab. ..
- Kim H, Jin J, Maxwell J, Fukuchi K. Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer's disease. Immunol Lett. 2007;112:30-8 pubmed
- Purohit P, Auerbach A. Acetylcholine receptor gating: movement in the alpha-subunit extracellular domain. J Gen Physiol. 2007;130:569-79 pubmed..This suggests that the inner and outer sheets of the alpha-subunit beta-core do not rotate as a rigid body...
- Stewart J, Ocon A, Clarke D, Taneja I, Medow M. Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome. Hypertension. 2009;53:767-74 pubmed publisher..Data imply impaired catabolism of Ang II through the ACE2 pathway. Vasoconstriction in POTS may result from a reduction in Ang-(1-7) and an increase in Ang II. ..
- Klucar P, Barnes P, Kong Y, Howard S, Pang X, Huang F, et al. Vaccination strategies to enhance local immunity and protection against Mycobacteriun tuberculosis. Vaccine. 2009;27:1816-24 pubmed..We conclude that CFP10 is a potential vaccine candidate and that coating vaccines with PEI enhances local protective immunity to tuberculosis ..
- Young S, Julka S, Bartley G, Gilbert J, Wendelburg B, Hung S, et al. Quantification of the sulfated cholecystokinin CCK-8 in hamster plasma using immunoprecipitation liquid chromatography-mass spectrometry/mass spectrometry. Anal Chem. 2009;81:9120-8 pubmed publisher..3% with a precision (percent coefficient of variation, % CV) of 15.5% over all samples in this 4 day period. Additionally, the method was used to determine increases of endogenous plasma CCK-8 in hamsters challenged with a high-fat meal. ..
- Armstrong A, Chen J, McKoy A, Hecht M. Mutations that replace aromatic side chains promote aggregation of the Alzheimer's A? peptide. Biochemistry. 2011;50:4058-67 pubmed publisher..These results suggest that aromatic ?-stacking interactions are not critical for A? aggregation or for the inhibition of A? aggregation. ..
- Pierceall W, Lena R, Medeiros B, Blake N, Doykan C, Elashoff M, et al. Mcl-1 dependence predicts response to vorinostat and gemtuzumab ozogamicin in acute myeloid leukemia. Leuk Res. 2014;38:564-8 pubmed publisher..75-1.00] with age adjustment) and overall survival (p=.027 logistic regression; AUC=0.87 [0.64-1.00; p=.0017]). This Mcl-1-dependence suggests a pivotal role of Bcl-2 family protein-mediated apoptosis to vorinostat/GO in AML patients. ..
- Johnson C, Reid D, Parker J, Salter S, Knihtila R, Kuzmic P, et al. The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects. J Biol Chem. 2017;292:12981-12993 pubmed publisher..We present the crystal structure of N-Ras bound to a GTP analogue and interpret the kinetic data in terms of structural features specific for H-, K-, and N-Ras. ..
- Beattie C, Kolva B, Siegel R. GABAA receptor subunit mRNA expression in the weaver cerebellum: modulation by cell-cell interactions. Brain Res Dev Brain Res. 1995;88:171-7 pubmed..In contrast, the absolute level of transcript expression attained appears to be modulated by cell-cell interactions or by other extrinsic cues present in the cerebellar environment. ..
- Torre V, Marozsan A, Albright J, Collins K, Hartley O, Offord R, et al. Variable sensitivity of CCR5-tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs. J Virol. 2000;74:4868-76 pubmed..Distribution of AOP-RANTES IC(50) values with these isolates has promoted ongoing screens for new CCR5 agonists that show broad inhibition of HIV-1 variants. ..
- Kudva Y, Deng Y, Govindarajan R, Abraham R, Marietta E, Notkins A, et al. HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2. Hum Immunol. 2001;62:1099-105 pubmed..In conclusion, we have identified IA-2 peptides that induce lymphoproliferative responses in DQ8 transgenic and NOD mice and shown that these peptides stimulate production of Th1 and Th2 cytokines. ..
- Kim J, Knapp D. Miniaturized multichannel electrospray ionization emitters on poly(dimethylsiloxane) microfluidic devices. Electrophoresis. 2001;22:3993-9 pubmed
- Garcia Garcia J, De La Fuente J, Kocan K, Blouin E, Halbur T, Onet V, et al. Mapping of B-cell epitopes in the N-terminal repeated peptides of Anaplasma marginale major surface protein 1a and characterization of the humoral immune response of cattle immunized with recombinant and whole organism antigens. Vet Immunol Immunopathol. 2004;98:137-51 pubmed..These results provide insight into the bovine antibody response against A. marginale and the role of MSP1a in protection of cattle against A. marginale infection. ..
- Enyeart J, Danthi S, Liu H, Enyeart J. Angiotensin II inhibits bTREK-1 K+ channels in adrenocortical cells by separate Ca2+- and ATP hydrolysis-dependent mechanisms. J Biol Chem. 2005;280:30814-28 pubmed..The novel Ca2+-dependent pathway is distinctive in its lack of ATP dependence, and is clearly different from the calmodulin kinase-dependent mechanism by which AngII modulates T-type Ca2+ channels in these cells. ..
- Li R, Pouranfar F, Lee S, Morris M, Wang Y, Gozal D. Neuroglobin protects PC12 cells against beta-amyloid-induced cell injury. Neurobiol Aging. 2008;29:1815-22 pubmed..Therefore, Ngb may act as an intracellular ROS scavenger, and such antioxidant properties may play a protective role against Abeta-induced cell injury. ..
- Thatcher S, Zhang X, Howatt D, Lu H, Gurley S, Daugherty A, et al. Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol. 2011;31:758-65 pubmed publisher..Coinfusion of Ang-(1-7) with Ang II reduced atherosclerosis. These results demonstrate that ACE2 deficiency in bone marrow-derived cells promotes atherosclerosis through regulation of Ang II/Ang-(1-7) peptides. ..
- Stamm J, Belloli E, Zhang Y, BON J, Sciurba F, Gladwin M. Elevated N-terminal pro-brain natriuretic peptide is associated with mortality in tobacco smokers independent of airflow obstruction. PLoS ONE. 2011;6:e27416 pubmed publisher..Future studies should assess the ability of this biomarker to guide further diagnostic testing and to direct specific cardiovascular risk reduction inventions that may positively impact quality of life and survival. ..
- Deane R, Singh I, Sagare A, Bell R, Ross N, LaRue B, et al. A multimodal RAGE-specific inhibitor reduces amyloid ?-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012;122:1377-92 pubmed publisher..Our data suggest that FPS-ZM1 is a potent multimodal RAGE blocker that effectively controls progression of A?-mediated brain disorder and that it may have the potential to be a disease-modifying agent for AD. ..
- Wang C, Wu L, Bulek K, Martin B, Zepp J, Kang Z, et al. The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90. Nat Immunol. 2013;14:72-81 pubmed publisher..In the absence of IL-17 signaling, IL-22 was the main contributor to skin inflammation, which provides a molecular mechanism for the association of Act1(D10N) with psoriasis susceptibility. ..
- Fang C, Stavrou E, Schmaier A, Grobe N, Morris M, Chen A, et al. Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2-/- mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation. Blood. 2013;121:3023-32 pubmed publisher..In Bdkrb2(-/-), combined AT2R and Mas overexpression produce elevated plasma prostacyclin and NO leading to acquired platelet function defects and thrombosis delay. ..
- Arachiche A, Mumaw M, de la Fuente M, Nieman M. Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by ?-thrombin. J Biol Chem. 2013;288:32553-62 pubmed publisher..Our findings show that PAR1 and PAR4 have dynamic interactions on the cell surface that should be taken into account when developing and characterizing PAR antagonists. ..
- Syu W, Kahan L. Epitope characterization by modifications of antigens and by mapping on resin-bound peptides. Discriminating epitopes near the C-terminus and N-terminus of Escherichia coli ribosomal protein S13. J Immunol Methods. 1989;118:153-60 pubmed..The other MAb, whose binding was inhibited by phthalylation, bound to the synthetic S13(2-22) and bound more strongly to the synthetic S13(1-22). ..
- Kazlauskas A, Cooper J. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell. 1989;58:1121-33 pubmed..Thus autophosphorylation may play a novel role in signal transduction via the PDGF-R. ..
- Kuo Y, Kokjohn T, Beach T, Sue L, Brune D, Lopez J, et al. Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains. J Biol Chem. 2001;276:12991-8 pubmed..The appraisal of therapeutic agents or protocols in these animal models must be judged in the context of the lack of complete equivalence between the transgenic mouse plaques and the human AD lesions. ..
- Suzuki S, Solberg L, Redei E, Handa R. Prepro-thyrotropin releasing hormone 178-199 immunoreactivity is altered in the hypothalamus of the Wistar-Kyoto strain of rat. Brain Res. 2001;913:224-33 pubmed..Such data fit with the hypothesis that PPTRH 178-199 is involved in the regulation of the HPA axis and behavior. ..
- Kanski J, Varadarajan S, Aksenova M, Butterfield D. Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide 1-42-associated oxidative stress and neurotoxicity. Biochim Biophys Acta. 2002;1586:190-8 pubmed..The results suggest that Gly33 may be a possible site of free radical propagation processes that are initiated on Met35 of Abeta(1-42) and that contribute to the peptide's toxicity in Alzheimer's disease brain. ..
- Nickoloff B, Qin J, Chaturvedi V, Denning M, Bonish B, Miele L. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002;9:842-55 pubmed..These results indicate that activation of Notch signaling is necessary for maturation of human epidermis, and activation by a soluble Notch ligand is sufficient to trigger complete KC differentiation including cornification. ..
- Oxenoid K, SONNICHSEN F, Sanders C. Topology and secondary structure of the N-terminal domain of diacylglycerol kinase. Biochemistry. 2002;41:12876-82 pubmed..The results, therefore, suggest that DAGK's active site lies very near to the water/bilayer interface. ..
- Kim Y, Rice A, Denu J. Intramolecular dephosphorylation of ERK by MKP3. Biochemistry. 2003;42:15197-207 pubmed..Catalytic activation and substrate tethering by MKP3 lead to a >or=4000-fold rate enhancement (k(cat)/K(m)) for dephosphorylation of pERK. ..
- Tucker H, Simpson J, Kihiko Ehmann M, Younkin L, McGillis J, Younkin S, et al. Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice. Neurosci Lett. 2004;368:285-9 pubmed..Hence, although plasmin is potentially important in the degradation of A beta aggregates, we interpret these data as suggesting that plasmin does not regulate steady-state A beta levels in non-pathologic conditions. ..
- Deal C, Omizo M, Schwartz E, Eriksen E, Cantor P, Wang J, et al. Combination teriparatide and raloxifene therapy for postmenopausal osteoporosis: results from a 6-month double-blind placebo-controlled trial. J Bone Miner Res. 2005;20:1905-11 pubmed..Further studies over longer treatment duration that include fracture endpoints are necessary to fully ascertain the clinical significance of combination raloxifene plus teriparatide therapy in postmenopausal osteoporosis. ..
- Daily A, Nath A, Hersh L. Tat peptides inhibit neprilysin. J Neurovirol. 2006;12:153-60 pubmed..Tat peptides and Tat protein were slowly hydrolyzed by neprilysin. Thus the accumulation of Tat-derived proteolytic fragments may serve to inhibit neprilysin and increase amyloid beta peptide levels. ..
- Warren M, Zheng W, Kobeissy F, Cheng Liu M, Hayes R, Gold M, et al. Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposure. Int J Neuropsychopharmacol. 2007;10:479-89 pubmed..The ability of the protease inhibitors to reduce the damage caused by these drugs suggests that the treatment arsenal could include similar drugs as possible tools to combat the drug-induced neurotoxicity in vivo. ..
- Hofstetter H, Toyka K, Tary Lehmann M, Lehmann P. Kinetics and organ distribution of IL-17-producing CD4 cells in proteolipid protein 139-151 peptide-induced experimental autoimmune encephalomyelitis of SJL mice. J Immunol. 2007;178:1372-8 pubmed..The selective enrichment of IL-17-producing CD4 cells in the CNS is suggestive of the pathogenic role of an independent (non-Th1) IL-17-producing proinflammatory effector T cell class in EAE. ..
- Murphy M, LeVine H. Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis. 2010;19:311-23 pubmed publisher..This raises important issues regarding the development and testing of future therapeutic agents. ..
- Karlsson A, Flessner R, Gellman S, Lynn D, Palecek S. Polyelectrolyte multilayers fabricated from antifungal β-peptides: design of surfaces that exhibit antifungal activity against Candida albicans. Biomacromolecules. 2010;11:2321-8 pubmed publisher..The layer-by-layer approach reported here could ultimately be used to coat the surfaces of catheters, surgical instruments, and other devices to inhibit drug-resistant C. albicans biofilm formation in clinical settings. ..
- Chan Y, Hackett K, Dillard J. The lytic transglycosylases of Neisseria gonorrhoeae. Microb Drug Resist. 2012;18:271-9 pubmed publisher..Here, we review the information available on these enzymes and discuss their roles in bacterial growth, cell separation, autolysis, type IV secretion, and pathogenesis...
- Parker M, Barten D, Bergstrom C, Bronson J, Corsa J, Dee M, et al. 2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as ?-secretase inhibitors. Bioorg Med Chem Lett. 2012;22:6828-31 pubmed publisher..A series of (N-benzyl-N-phenylsulfonamido)alkyl amides were developed from classic and parallel synthesis strategies. Compounds with good in vitro and in vivo ?-secretase activity were identified and described. ..
- Kim J, Monroe M, Camp D, Smith R, Qian W. In-source fragmentation and the sources of partially tryptic peptides in shotgun proteomics. J Proteome Res. 2013;12:910-6 pubmed publisher..Our work also provides a method to identify such proteolytic-derived partially tryptic peptides due to endogenous proteases in the samples by removing in-source fragmentation artifacts from the identified peptides. ..
- Lopez Buesa P, Pfund C, Craig E. The biochemical properties of the ATPase activity of a 70-kDa heat shock protein (Hsp70) are governed by the C-terminal domains. Proc Natl Acad Sci U S A. 1998;95:15253-8 pubmed..The differential influence of the peptide-binding domain on the ATPase domain may, in part, explain the functional uniqueness of these two classes of Hsp70s. ..
- Combs C, Johnson D, Cannady S, Lehman T, Landreth G. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins. J Neurosci. 1999;19:928-39 pubmed..This toxicity can be ameliorated by treating THP-1 cells with specific enzyme inhibitors that target various components of the signal transduction pathway linked to the inflammatory responses. ..
- Boackle R, Dutton S, Robinson W, Vesely J, Lever J, Su H, et al. Effects of removing the negatively charged N-terminal region of the salivary acidic proline-rich proteins by human leucocyte elastase. Arch Oral Biol. 1999;44:575-85 pubmed..High concentrations of human leucocyte elastase, arriving from inflammatory gingival crevicular exudates, may interrupt the normal binding of fluid-phase acidic PRPs to hydroxyapatite. ..
- Hale C, Rhee A, de Boer P. ZipA-induced bundling of FtsZ polymers mediated by an interaction between C-terminal domains. J Bacteriol. 2000;182:5153-66 pubmed..Thus, in addition to the C-terminal FZB domain, the N-terminal domain of ZipA is required for ZipA function. Furthermore, the essential properties of the N domain may be more specific than merely acting as a membrane anchor. ..
- Chen Q, Cai S, Shadrach K, Prestwich G, Hollyfield J. Spacrcan binding to hyaluronan and other glycosaminoglycans. Molecular and biochemical studies. J Biol Chem. 2004;279:23142-50 pubmed..These studies provide the first evidence defining the sites of protein-carbohydrate interaction of molecules present in the IPM. ..
- Boules M, Fredrickson P, Richelson E. Neurotensin agonists as an alternative to antipsychotics. Expert Opin Investig Drugs. 2005;14:359-69 pubmed..In this review, we present the rationale for development of NT receptor agonists for treatment of certain central nervous system diseases, as well as a review of those peptide agonists that are in early stages of development. ..
- Kawabe J, Okumura S, Nathanson M, Hasebe N, Ishikawa Y. Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. Biochem Biophys Res Commun. 2006;342:164-9 pubmed..Accordingly, it is most likely that caveolin increased the polymer form of microtubule through the inhibition of a microtubule destabilizer, stathmin, suggesting a novel role of caveolin in regulating cellular network and trafficking. ..
- Zamora E, Handisurya A, Shafti Keramat S, Borchelt D, Rudow G, Conant K, et al. Papillomavirus-like particles are an effective platform for amyloid-beta immunization in rabbits and transgenic mice. J Immunol. 2006;177:2662-2670 pubmed..These results indicate that the Abeta-VLP vaccine induces an effective humoral immune response to Abeta and may thus form a basis to develop a safe and efficient immunotherapy for human AD. ..
- Kenward A, Bartolotti L, Burns C. Copper and zinc promote interactions between membrane-anchored peptides of the metal binding domain of the prion protein. Biochemistry. 2007;46:4261-71 pubmed..Overall, our results indicate that PrP may be a bifunctional molecule capable of responding to fluctuations in both neuronal Cu2+ and Zn2+ levels. ..
- Liu Q, Liu Z, Rozo C, Hamed H, Alem F, Urban J, et al. The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response. J Immunol. 2007;179:3821-30 pubmed..10 T cells. These results suggest that B cells, expressing B7 costimulatory molecules, are required in the absence of an underlying IFN-gamma-mediated response for the development of a polarized primary Ag-specific Th2 response in vivo. ..
- Yuan J, Dong Z, Guo J, McGeehan J, Xiao X, Wang J, et al. Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions. Cell Mol Life Sci. 2008;65:631-43 pubmed publisher..Our study suggests that an increase in the level of PrP*20 characterizes the early stages of prion diseases. ..
- Lima F, Henderson J, Reddy A, Tokuyama Y, Hubert G, Kuhar M, et al. Unique responses of midbrain CART neurons in macaques to ovarian steroids. Brain Res. 2008;1227:76-88 pubmed publisher..Together, the data suggest that CART neurons in the midbrain have a unique steroid response, which may be mediated by nuclear receptors, neuroactive steroids or interneurons. ..
- Nickells R. Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Exp Eye Res. 2010;91:2-8 pubmed publisher..Studies of retinal ganglion cell apoptosis indicate that a threshold of BAX expression is required for its successful activation, which is independent of the overall concentration of anti-apoptotic proteins in these cells. ..
- Verma A, Shan Z, Lei B, Yuan L, Liu X, Nakagawa T, et al. ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Mol Ther. 2012;20:28-36 pubmed publisher..Increased expression of ACE2/Ang-(1-7) overcomes this imbalance and confers protection against DR. Thus, strategies enhancing the protective ACE2/Ang-(1-7) axis of RAS in the eye could serve as a novel therapeutic target for DR. ..
- Zhang Y, Zhang J, Yuan C, Hard R, Park I, Li C, et al. Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry. 2011;50:7637-46 pubmed publisher..Our findings suggest a potential new function for the SH2 domain as a molecular clamp to promote dimerization of signaling proteins. ..
- Miguel Hidalgo J, Paul I, Wanzo V, Banerjee P. Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid ?1-40. Eur J Pharmacol. 2012;692:38-45 pubmed publisher..These data suggest that, in rats, memantine can prevent amyloid-triggered expression of apoptosis-related markers and concomitant cognitive deficits. ..
- Reynolds M, Singh I, Azad T, Holmes B, Verghese P, Dietrich H, et al. Heparan sulfate proteoglycans mediate AÎ²-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells. Mol Neurodegener. 2016;11:9 pubmed publisher..Taken together, our data indicate that HSPG are critical mediators of AÎ²-induced oxidative stress and AÎ²(1-40â»)induced VSMC dysfunction. ..
- Brandt U, Yu L, Yu C, Trumpower B. The mitochondrial targeting presequence of the Rieske iron-sulfur protein is processed in a single step after insertion into the cytochrome bc1 complex in mammals and retained as a subunit in the complex. J Biol Chem. 1993;268:8387-90 pubmed..This is apparently the first instance in which a cleaved targeting presequence has been shown to be retained in the cell, possibly exhibiting a second function in addition to its function in protein trafficking. ..
- Hu H, Gao N, Liu S, Ren J, Wang X, Xia Y, et al. Action of bradykinin in the submucosal plexus of guinea pig small intestine. J Pharmacol Exp Ther. 2004;309:320-7 pubmed..Pathophysiological significance of the excitatory actions on secretomotor neurons might be stimulated mucosal secretion and the secretory diarrhea associated with intestinal inflammatory states. ..
- McClung M, San Martin J, Miller P, Civitelli R, Bandeira F, Omizo M, et al. Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass. Arch Intern Med. 2005;165:1762-8 pubmed..2% and 7.7%, respectively; P = .05). Two distinct options for the management of osteoporosis lead to increases in BMD by opposite mechanisms of action on bone remodeling. ..
- Hippen B, Demattos A, Cook W, Kew C, Gaston R. Association of CD20+ infiltrates with poorer clinical outcomes in acute cellular rejection of renal allografts. Am J Transplant. 2005;5:2248-52 pubmed..This study supports prospective identification of CD20-positive B-cell clusters in biopsy-proven rejection and offers a therapeutic rationale for a trial of monoclonal anti-CD20 antibody in such patients. ..
- Kim H, Maxwell J, Kong F, Tang D, Fukuchi K. Induction of anti-inflammatory immune response by an adenovirus vector encoding 11 tandem repeats of Abeta1-6: toward safer and effective vaccines against Alzheimer's disease. Biochem Biophys Res Commun. 2005;336:84-92 pubmed..Thus, the adenovirus vector encoding 11 tandem repeats of Abeta1-6 may be a safer alterative to peptide-based vaccines. ..
- Liao T, Ke Y, Shao W, Haribabu B, Kaplan H, Sun D, et al. Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis. Invest Ophthalmol Vis Sci. 2006;47:1543-9 pubmed..The results demonstrate a critical role for LTB4 in ocular inflammation and in the development and progression of EAU and suggest a new potential target for therapeutic intervention in this disease. ..
- Madsen J, Brodbelt J. Comparison of infrared multiphoton dissociation and collision-induced dissociation of supercharged peptides in ion traps. J Am Soc Mass Spectrom. 2009;20:349-58 pubmed publisher..The enhanced sequence coverage afforded by IRMPD of supercharged ions was demonstrated for a variety of model peptides, as well as for a tryptic digest of cytochrome c...
- Hildreth B, Werbeck J, Thudi N, Deng X, Rosol T, Toribio R. PTHrP 1-141 and 1-86 increase in vitro bone formation. J Surg Res. 2010;162:e9-17 pubmed publisher..The NLS and C-terminus have anabolic effects distinct from the N-terminus. This demonstrates the advantage of PTHrP 1-141 as a skeletal anabolic agent. ..
- Chen S, Yadav S, Surewicz W. Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues. J Biol Chem. 2010;285:26377-83 pubmed publisher..This insight may help explain the interplay between the postulated protective and pathogenic roles of PrP in AD and may contribute to the development of novel therapeutic strategies as well. ..
- Yadav R, Bhowmick S, Gorecki P, O Rourke J, Cone R. Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice. PLoS ONE. 2010;5:e11983 pubmed publisher..We hypothesized that the facilitation of experimental autoimmunity by PTX suggests that its influence on the in vivo immune response to auto-antigen may differ from its influence on non-self antigens...
- Santhoshkumar P, Raju M, Sharma K. ?A-crystallin peptide SDRDKFVIFLDVKHF accumulating in aging lens impairs the function of ?-crystallin and induces lens protein aggregation. PLoS ONE. 2011;6:e19291 pubmed publisher..The accumulation of such peptides in aging lenses may explain a novel mechanism for age-related crystallin aggregation and cataractogenesis. ..
- Jack C, Vemuri P, Wiste H, Weigand S, Lesnick T, Lowe V, et al. Shapes of the trajectories of 5 major biomarkers of Alzheimer disease. Arch Neurol. 2012;69:856-67 pubmed..Creating reliable models that describe the full trajectories of Alzheimer disease biomarkers will require significant additional longitudinal data in individual participants. ..