Experts and Doctors on peptide elongation factor tu in United States


Locale: United States
Topic: peptide elongation factor tu

Top Publications

  1. Fu J, Momcilovic I, Clemente T, Nersesian N, Trick H, Ristic Z. Heterologous expression of a plastid EF-Tu reduces protein thermal aggregation and enhances CO2 fixation in wheat (Triticum aestivum) following heat stress. Plant Mol Biol. 2008;68:277-88 pubmed publisher
    ..The results strongly suggest that heat tolerance of wheat, and possibly other crop plants, can be improved by modulating expression of plastidal EF-Tu and/or by selection of genotypes with increased endogenous levels of this protein. ..
  2. Fu J, Ristic Z. Analysis of transgenic wheat (Triticum aestivum L.) harboring a maize (Zea mays L.) gene for plastid EF-Tu: segregation pattern, expression and effects of the transgene. Plant Mol Biol. 2010;73:339-47 pubmed publisher
    ..Moreover, the results also support the hypothesis that EF-Tu contributes to heat tolerance by acting as a molecular chaperone and protecting heat-labile proteins from thermal aggregation in a non-specific manner. ..
  3. Kudlicki W, Coffman A, Kramer G, Hardesty B. Renaturation of rhodanese by translational elongation factor (EF) Tu. Protein refolding by EF-Tu flexing. J Biol Chem. 1997;272:32206-10 pubmed
    ..The results lead to the conclusion that flexing of EF-Tu, especially as occurs between its open and closed conformations, is a major factor in its chaperone-like refolding activity. ..
  4. Gaucher E, Thomson J, Burgan M, Benner S. Inferring the palaeoenvironment of ancient bacteria on the basis of resurrected proteins. Nature. 2003;425:285-8 pubmed
    ..The study illustrates the use of experimental palaeobiochemistry and assumptions about deep phylogenetic relationships between bacteria to explore the character of ancient life. ..
  5. Fouad A, Zerella J, Barry J, Spangberg L. Molecular detection of Enterococcus species in root canals of therapy-resistant endodontic infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:112-8 pubmed
    ..1; chi squared, P = .45). Phylogenetically, all sequences from positive specimens matched E faecalis V583 (AE016947). Conclusion E faecalis was the only enterococcal species detected, with an overall prevalence of 22%. ..
  6. Ristic Z, Momcilovic I, Fu J, Callegari E, DeRidder B. Chloroplast protein synthesis elongation factor, EF-Tu, reduces thermal aggregation of rubisco activase. J Plant Physiol. 2007;164:1564-71 pubmed
    ..The results are consistent with the hypothesis that chloroplast EF-Tu plays a functional role in heat tolerance by acting as a molecular chaperone. ..
  7. Kooken J, Fox K, Fox A, Altomare D, CREEK K, Wunschel D, et al. Identification of staphylococcal species based on variations in protein sequences (mass spectrometry) and DNA sequence (sodA microarray). Mol Cell Probes. 2014;28:41-50 pubmed publisher
    ..Alternatively on full proteomics analysis elongation factor Tu generally provided the highest confidence in staphylococcal speciation. ..
  8. Wower I, Wower J, Zimmermann R. Ribosomal protein L27 participates in both 50 S subunit assembly and the peptidyl transferase reaction. J Biol Chem. 1998;273:19847-52 pubmed
    ..We therefore infer that L27 contributes to peptide bond formation by facilitating the proper placement of the acceptor end of the A-site tRNA at the peptidyl transferase center. ..
  9. Ristic Z, Bukovnik U, Momcilovic I, Fu J, Vara Prasad P. Heat-induced accumulation of chloroplast protein synthesis elongation factor, EF-Tu, in winter wheat. J Plant Physiol. 2008;165:192-202 pubmed
    ..Young plants of all cultivars but one did not show significant increases in the relative levels of EF-Tu. The results of the study suggest that EF-Tu protein may play a role in heat tolerance in winter wheat. ..

More Information


  1. Banerjee R, Chen S, Dare K, Gilreath M, Praetorius Ibba M, Raina M, et al. tRNAs: cellular barcodes for amino acids. FEBS Lett. 2010;584:387-95 pubmed publisher
    ..Here we review examples of alternative functions for tRNA beyond translation, which together suggest that the role of tRNA is to deliver amino acids for a variety of processes that includes, but is not limited to, protein synthesis. ..
  2. Gaucher E, Govindarajan S, Ganesh O. Palaeotemperature trend for Precambrian life inferred from resurrected proteins. Nature. 2008;451:704-7 pubmed publisher
    ..The convergence of results from natural and physical sciences suggest that ancient life has continually adapted to changes in environmental temperatures throughout its evolutionary history. ..
  3. Abel K, Yoder M, Hilgenfeld R, Jurnak F. An alpha to beta conformational switch in EF-Tu. Structure. 1996;4:1153-9 pubmed
    ..The alpha to beta switch in EF-Tu may represent a prototypical activation mechanism for other protein families. ..
  4. Ling J, So B, Yadavalli S, Roy H, Shoji S, Fredrick K, et al. Resampling and editing of mischarged tRNA prior to translation elongation. Mol Cell. 2009;33:654-60 pubmed publisher
    ..Resampling of mischarged tRNAs was shown to increase the accuracy of translation over ten fold during in vitro protein synthesis, supporting the presence of an additional quality control step prior to translation elongation. ..
  5. Roy H, Ibba M. RNA-dependent lipid remodeling by bacterial multiple peptide resistance factors. Proc Natl Acad Sci U S A. 2008;105:4667-72 pubmed publisher
    ..Taken together, our findings reveal how the MprF proteins provide a potent virulence mechanism by which pathogens can readily acquire resistance to chemically diverse antibiotics. ..
  6. Delwiche C, Kuhsel M, Palmer J. Phylogenetic analysis of tufA sequences indicates a cyanobacterial origin of all plastids. Mol Phylogenet Evol. 1995;4:110-28 pubmed publisher
  7. Cafaro M, Poulsen M, Little A, Price S, Gerardo N, Wong B, et al. Specificity in the symbiotic association between fungus-growing ants and protective Pseudonocardia bacteria. Proc Biol Sci. 2011;278:1814-22 pubmed publisher
    ..Our findings support a model that many fungus-growing ants maintain specialized Pseudonocardia symbionts that help with garden defence. ..
  8. Poulsen M, Erhardt D, Molinaro D, Lin T, Currie C. Antagonistic bacterial interactions help shape host-symbiont dynamics within the fungus-growing ant-microbe mutualism. PLoS ONE. 2007;2:e960 pubmed
  9. Zicker A, Kadakia C, Herrin D. Distinct roles for the 5' and 3' untranslated regions in the degradation and accumulation of chloroplast tufA mRNA: identification of an early intermediate in the in vivo degradation pathway. Plant Mol Biol. 2007;63:689-702 pubmed publisher
    ..These data indicate that the in vivo degradation of tufA mRNA begins in the 5' UTR, and is promoted by translation. The data also suggest, however, that the level of the mature RNA is determined more by the 3' UTR than the 5' UTR...
  10. Kristelly R, Gao G, Tesmer J. Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J Biol Chem. 2004;279:47352-62 pubmed
    ..Similar changes were previously observed in structures of nucleotide-free Ras and Ef-Tu. A potential protein-docking site on the LARG PH domain is also evident and appears to be conserved throughout the Lbc subfamily of RhoGEFs. ..
  11. Zhang M, Poulsen M, Currie C. Symbiont recognition of mutualistic bacteria by Acromyrmex leaf-cutting ants. ISME J. 2007;1:313-20 pubmed
  12. Ling J, Roy H, Qin D, Rubio M, Alfonzo J, Fredrick K, et al. Pathogenic mechanism of a human mitochondrial tRNAPhe mutation associated with myoclonic epilepsy with ragged red fibers syndrome. Proc Natl Acad Sci U S A. 2007;104:15299-304 pubmed
    ..This variant enzyme displayed significantly improved aminoacylation efficiency for the G34A mutant, suggesting a general strategy to treat certain classes of mitochondrial diseases by modification of the corresponding nuclear gene...
  13. Roth W, Bragg P, Corrias M, Reddy N, Dholakia J, Wahba A. Expression of a gene for mouse eucaryotic elongation factor Tu during murine erythroleukemic cell differentiation. Mol Cell Biol. 1987;7:3929-36 pubmed
    ..In addition, we have isolated and sequenced a cDNA clone for mouse eEF-Tu. The derived amino acid sequence is compared with sequences from other eucaryotes. ..