Experts and Doctors on peptide elongation factor tu in France


Locale: France
Topic: peptide elongation factor tu

Top Publications

  1. Laalami S, Grentzmann G, Bremaud L, Cenatiempo Y. Messenger RNA translation in prokaryotes: GTPase centers associated with translational factors. Biochimie. 1996;78:577-89 pubmed
    ..Of the prokaryotic translational factors, IF2, EF-Tu, SELB, EF-G and RF3 are GTP-binding proteins. In this review we summarize the latest findings on the structures and the roles of these GTPases in the translational process. ..
  2. Mignard S, Flandrois J. Identification of Mycobacterium using the EF-Tu encoding (tuf) gene and the tmRNA encoding (ssrA) gene. J Med Microbiol. 2007;56:1033-41 pubmed
    ..tuf gene analysis suggests that this gene could be used effectively for phylogenetic analysis and to identify mycobacteria. ..
  3. Créchet J, Malosse C, Hountondji C. EF-Tu from the enacyloxin producing Frateuria W-315 strain: Structure/activity relationship and antibiotic resistance. Biochimie. 2016;127:59-69 pubmed publisher
    ..Finally, up to a 7 fold stimulation was observed with the quadruple substitution (mutant A42E/A45K/F46Y/Q48E. ..
  4. Tarrago L, Kieffer Jaquinod S, Lamant T, Marcellin M, Garin J, Rouhier N, et al. Affinity chromatography: a valuable strategy to isolate substrates of methionine sulfoxide reductases?. Antioxid Redox Signal. 2012;16:79-84 pubmed publisher
    ..In consequence, we propose that affinity chromatography constitutes an efficient tool to isolate physiological targets of MSRs. ..
  5. Seyer P, Grandemange S, Busson M, Carazo A, Gamaléri F, Pessemesse L, et al. Mitochondrial activity regulates myoblast differentiation by control of c-Myc expression. J Cell Physiol. 2006;207:75-86 pubmed
    ..These results suggest that irreversible myoblast withdrawal from the cell cycle is a target of mitochondrial activity by control of c-Myc expression. ..
  6. Anborgh P, Okamura S, Parmeggiani A. Effects of the antibiotic pulvomycin on the elongation factor Tu-dependent reactions. Comparison with other antibiotics. Biochemistry. 2004;43:15550-6 pubmed
    ..Specific differences and similarities between the action of pulvomycin and the other EF-Tu-specific antibiotics are described and discussed. ..
  7. Cetin R, Krab I, Anborgh P, Cool R, Watanabe T, Sugiyama T, et al. Enacyloxin IIa, an inhibitor of protein biosynthesis that acts on elongation factor Tu and the ribosome. EMBO J. 1996;15:2604-11 pubmed
    ..Therefore, it is the first antibiotic found to have a dual specificity targeted to EF-Tu and the ribosome. ..
  8. Rohou H, Francisci S, Rinaldi T, Frontali L, Bolotin Fukuhara M. Reintroduction of a characterized Mit tRNA glycine mutation into yeast mitochondria provides a new tool for the study of human neurodegenerative diseases. Yeast. 2001;18:219-27 pubmed
    ..The method will provide important applications for the use of yeast as a model system of human mitochondrial pathologies. ..
  9. Cetin R, Anborgh P, Cool R, Parmeggiani A. Functional role of the noncatalytic domains of elongation factor Tu in the interactions with ligands. Biochemistry. 1998;37:486-95 pubmed

More Information


  1. Grandemange S, Seyer P, Carazo A, Becuwe P, Pessemesse L, Busson M, et al. Stimulation of mitochondrial activity by p43 overexpression induces human dermal fibroblast transformation. Cancer Res. 2005;65:4282-91 pubmed
    ..These data indicate that stimulation of mitochondrial activity in human dermal fibroblasts induces cell transformation through events involving ROS production. ..
  2. Krab I, te Biesebeke R, Bernardi A, Parmeggiani A. Elongation factor Ts can act as a steric chaperone by increasing the solubility of nucleotide binding-impaired elongation factor-Tu. Biochemistry. 2001;40:8531-5 pubmed
  3. Théobald Dietrich A, Frugier M, Giege R, Rudinger Thirion J. Atypical archaeal tRNA pyrrolysine transcript behaves towards EF-Tu as a typical elongator tRNA. Nucleic Acids Res. 2004;32:1091-6 pubmed
  4. Feuermann M, Francisci S, Rinaldi T, De Luca C, Rohou H, Frontali L, et al. The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. EMBO Rep. 2003;4:53-8 pubmed
  5. Malki A, Caldas T, Parmeggiani A, Kohiyama M, Richarme G. Specificity of elongation factor EF-TU for hydrophobic peptides. Biochem Biophys Res Commun. 2002;296:749-54 pubmed
    ..Our results suggest that EF-Tu, like DnaK, interacts albeit more weakly with the hydrophobic regions of substrate protein and are consistent with the hypothesis that it possesses chaperone properties. ..
  6. Guinet F, Frank R, Leberman R. Polypeptide elongation factor Tu from Halobacterium marismortui. Eur J Biochem. 1988;172:687-94 pubmed
    ..The protein possesses typical halophilic characteristics, in that it is stable and active in 3 M KCl or 2 M (NH4)2SO4. Some other properties, like autofragmentation under sample treatment before SDS-PAGE, are described. ..
  7. Menez J, Heurgué Hamard V, Buckingham R. Sequestration of specific tRNA species cognate to the last sense codon of an overproduced gratuitous protein. Nucleic Acids Res. 2000;28:4725-32 pubmed
  8. Berrier C, Garrigues A, Richarme G, Ghazi A. Elongation factor Tu and DnaK are transferred from the cytoplasm to the periplasm of Escherichia coli during osmotic downshock presumably via the mechanosensitive channel mscL. J Bacteriol. 2000;182:248-51 pubmed
  9. Guillon J, Heiss S, Soutourina J, Mechulam Y, Laalami S, Grunberg Manago M, et al. Interplay of methionine tRNAs with translation elongation factor Tu and translation initiation factor 2 in Escherichia coli. J Biol Chem. 1996;271:22321-5 pubmed
    ..M., Mechulam, Y., Schmitter, J.-M., Blanquet, S., and Fayat, G. (1992) J. Bacteriol. 174, 4294-4301. ..
  10. Kawashima T, Berthet Colominas C, Wulff M, Cusack S, Leberman R. The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution. Nature. 1996;379:511-8 pubmed publisher
    ..The interaction of EF-Ts with EF-Tu results principally in the disruption of the Mg2+ ion binding site, thereby reducing the affinity of EF-Tu for guanine nucleotides...