Experts and Doctors on parathyroid hormone related protein in United States


Locale: United States
Topic: parathyroid hormone related protein

Top Publications

  1. Gilmore J, Scott J, Bouizar Z, Robling A, Pitfield S, Riese D, et al. Amphiregulin-EGFR signaling regulates PTHrP gene expression in breast cancer cells. Breast Cancer Res Treat. 2008;110:493-505 pubmed
    ..Taken together, it appears that autocrine stimulation of EGFR signaling by amphiregulin is coupled to PTHrP gene expression via EGFR Tyr992 and MAPK, and that this pathway may contribute to PTHrP expression by breast tumor cells. ..
  2. Dong Y, Drissi H, Chen M, Chen D, Zuscik M, Schwarz E, et al. Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta. J Cell Biochem. 2005;95:1057-68 pubmed
    ..Moreover, this pathway is modulated by members of the TGF-beta family and demonstrates the highly integrated nature of signals controlling endochondral ossification. ..
  3. Schnatz P, Curry S. Primary hyperparathyroidism in pregnancy: evidence-based management. Obstet Gynecol Surv. 2002;57:365-76 pubmed
  4. Kornberg L, Villaret D, Popp M, Lui L, McLaren R, Brown H, et al. Gene expression profiling in squamous cell carcinoma of the oral cavity shows abnormalities in several signaling pathways. Laryngoscope. 2005;115:690-8 pubmed
    ..Further work is needed to determine the role of these genes in the development and progression of oral SCC. ..
  5. Tannehill Gregg S, Kergosien E, Rosol T. Feline head and neck squamous cell carcinoma cell line: characterization, production of parathyroid hormone-related protein, and regulation by transforming growth factor-beta. In Vitro Cell Dev Biol Anim. 2001;37:676-83 pubmed
    ..The SCCF1 cell line will permit mechanistic experiments on genetic dysregulation in neoplastic keratinocytes of the feline oropharynx, and development of an in vitro model for H/N cancer. ..
  6. Hildreth B, Werbeck J, Thudi N, Deng X, Rosol T, Toribio R. PTHrP 1-141 and 1-86 increase in vitro bone formation. J Surg Res. 2010;162:e9-17 pubmed publisher
    ..The NLS and C-terminus have anabolic effects distinct from the N-terminus. This demonstrates the advantage of PTHrP 1-141 as a skeletal anabolic agent. ..
  7. Ionescu A, Drissi H, Schwarz E, Kato M, Puzas J, McCance D, et al. CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter. J Cell Physiol. 2004;198:428-40 pubmed
  8. Lorch G, Gilmore J, Koltz P, Gonterman R, Laughner R, Lewis D, et al. Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice. Br J Cancer. 2007;97:183-93 pubmed
    ..Inhibition of the EGFR pathway in two human SCC models of HHM by an anilinoquinazoline demonstrated that the EGFR tyrosine kinase is a potential target for antihypercalcaemic therapy. ..
  9. Damron T, Mathur S, Horton J, Strauss J, Margulies B, Grant W, et al. Temporal changes in PTHrP, Bcl-2, Bax, caspase, TGF-beta, and FGF-2 expression following growth plate irradiation with or without radioprotectant. J Histochem Cytochem. 2004;52:157-67 pubmed
    ..These findings underscore the importance of PTHrP in response to growth plate irradiation and show the novel finding of a decrease in Bax expression with amifostine pretreatment. ..

More Information


  1. Nadella M, Dirksen W, Nadella K, Shu S, Cheng A, Morgenstern J, et al. Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma. Leukemia. 2007;21:1752-62 pubmed
    ..In summary, the data demonstrated that transcriptional regulation of PTHrP in ATLL cells can be controlled by NF-kappaB activation and also suggest a Tax-independent mechanism of activation of PTHrP in ATLL. ..
  2. Parrula C, Zimmerman B, Nadella P, Shu S, Rosol T, Fernandez S, et al. Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T-cell leukemia. Vet Pathol. 2009;46:1003-14 pubmed publisher
    ..The MET-1/NOD/SCID model will be useful for developing interventions against invasion and spread of leukemic cells and subsequent humoral hypercalcemia of malignancy. ..
  3. Sellers R, Capen C, Rosol T. Messenger RNA stability of parathyroid hormone-related protein regulated by transforming growth factor-beta1. Mol Cell Endocrinol. 2002;188:37-46 pubmed
    ..These studies revealed that TGFbeta1-induced PTHrP mRNA stability might be, in part, the result of cis-acting sequences within the coding region of the PTHrP mRNA. ..
  4. Damron T, Horton J, Naqvi A, Loomis R, Margulies B, Strauss J, et al. Combination radioprotectors maintain proliferation better than single agents by decreasing early parathyroid hormone-related protein changes after growth plate irradiation. Radiat Res. 2006;165:350-8 pubmed
  5. Wojcik S, Schanbacher F, McCauley L, Zhou H, Kartsogiannis V, Capen C, et al. Cloning of bovine parathyroid hormone-related protein (PTHrP) cDNA and expression of PTHrP mRNA in the bovine mammary gland. J Mol Endocrinol. 1998;20:271-80 pubmed
    ..Expression of PTHrP mRNA was demonstrated in the mammary gland during late pregnancy and throughout lactation in cows. ..
  6. Wealthall R. In vitro regulation of proliferation and differentiation within a postnatal growth plate of the cranial base by parathyroid hormone-related peptide (PTHrP). J Cell Physiol. 2009;219:688-97 pubmed publisher
    ..These results provide the first functional evidence that PTHrP regulates proliferation and differentiation within the postnatal, cranial growth plate. J. Cell. Physiol. 219: 688-697, 2009. (c) 2009 Wiley-Liss, Inc...
  7. Grone A, Weckmann M, Blomme E, Capen C, Rosol T. Dependence of humoral hypercalcemia of malignancy on parathyroid hormone-related protein expression in the canine anal sac apocrine gland adenocarcinoma (CAC-8) nude mouse model. Vet Pathol. 1998;35:344-51 pubmed
    ..Messenger RNA expression of TGF beta, TNF alpha, IL-1, and IL-6 was similar in both tumors and was consistent with the central role of PTHrP in the induction of hypercalcemia in this animal model. ..
  8. Sellers R, Luchin A, Richard V, Brena R, Lima D, Rosol T. Alternative splicing of parathyroid hormone-related protein mRNA: expression and stability. J Mol Endocrinol. 2004;33:227-41 pubmed
  9. Rosol T, Capen C, Danks J, Suva L, Steinmeyer C, Hayman J, et al. Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac. Vet Pathol. 1990;27:89-95 pubmed
    ..These data demonstrated that canine tissues contained a homologue to human PTHrP that likely is important in the pathogenesis of humoral hypercalcemia of malignancy...
  10. Nervina J, Tetradis S, Huang Y, Harrison D, Molina C, Kream B. Expression of inducible cAMP early repressor is coupled to the cAMP-protein kinase A signaling pathway in osteoblasts. Bone. 2003;32:483-90 pubmed
    ..Finally, PTH, FSK, and PTHrP induced ICER in cultured mouse calvariae and osteoblastic ROS 17/2.8, UMR-106, and Pyla cells. We conclude that ICER expression in osteoblasts requires activation of the cAMP-PKA signaling pathway. ..
  11. Cho Y, Woodard G, Dunbar M, Gocken T, Jimenez J, Foley J. Hair-cycle-dependent expression of parathyroid hormone-related protein and its type I receptor: evidence for regulation at the anagen to catagen transition. J Invest Dermatol. 2003;120:715-27 pubmed
    ..It appears that parathyroid hormone-related protein and fibroblast growth factor-5 regulate the anagen to catagen transition by independent pathways. ..
  12. Toribio R, Brown H, Novince C, Marlow B, Hernon K, Lanigan L, et al. The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. FASEB J. 2010;24:1947-57 pubmed publisher
    ..The down-regulation of Runx1, Runx2, and Sox9 indicates that PTHrP is a modulator of transcriptional activation during stem cell commitment. ..
  13. Abdalkhani A, Sellers R, Gent J, Wulitich H, Childress S, Stein B, et al. Nipple connective tissue and its development: insights from the K14-PTHrP mouse. Mech Dev. 2002;115:63-77 pubmed
  14. Gilmore J, Gonterman R, Menon K, LORCH G, Riese D, Robling A, et al. Reconstitution of amphiregulin-epidermal growth factor receptor signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone. Mol Cancer Res. 2009;7:1714-28 pubmed publisher
    ..Taken together, we provide evidence that AREG stimulation of EGFR results in high levels of PTHrP gene expression, contributing to cancer-associated bone pathology. ..
  15. Nadella M, Shu S, Dirksen W, Thudi N, Nadella K, Fernandez S, et al. Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformation. Retrovirology. 2008;5:46 pubmed publisher
    ..These data demonstrate that PTHrP and its receptor are up-regulated specifically during immortalization of T-lymphocytes by HTLV-1 infection and may facilitate the transformation process. ..
  16. Smits P, Dy P, Mitra S, Lefebvre V. Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol. 2004;164:747-58 pubmed
    ..In conclusion, Sox5 and Sox6 are needed for the establishment of multilayered growth plates, and thereby for proper and timely development of endochondral bones. ..
  17. Deng X, Tannehill Gregg S, Nadella M, He G, Levine A, Cao Y, et al. Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases. Clin Exp Metastasis. 2007;24:107-19 pubmed
  18. Richard V, Nadella M, Green P, Lairmore M, Feuer G, Foley J, et al. Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma. Leukemia. 2005;19:1175-83 pubmed
    ..Our data demonstrate that transcriptional regulation of PTHrP in ATLL cells can be controlled by T-cell receptor signaling and the ETS and MAPK ERK pathway in a Tax-independent manner. ..
  19. Zhang D, Schwarz E, Rosier R, Zuscik M, Puzas J, O Keefe R. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res. 2003;18:1593-604 pubmed
    ..The findings suggest that BMPs are integrated into the Ihh/PTHrP signaling loop and that a fine balance of BMP signaling is essential for normal chondrocyte maturation and skeletal development. ..
  20. Foley J, Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, et al. Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development. 2001;128:513-25 pubmed
    ..Finally, PTHrP signaling regulates the epidermal and mesenchymal expression of LEF1 and (&bgr;)-catenin, suggesting that these changes in cell fate involve an interaction between the PTHrP and Wnt signaling pathways. ..
  21. Grone A, Weckmann M, Capen C, Rosol T. Regulation of parathyroid hormone-related protein expression in a canine squamous carcinoma cell line by colchicine. Exp Toxicol Pathol. 1998;50:365-70 pubmed
    ..An increase in PTHrP production during mitosis of malignant epithelial cells may be important in the pathogenesis of humoral hypercalcemia of malignancy. ..
  22. Rosol T, Steinmeyer C, McCauley L, Grone A, DeWille J, Capen C. Sequences of the cDNAs encoding canine parathyroid hormone-related protein and parathyroid hormone. Gene. 1995;160:241-3 pubmed
    ..The cPTHrP cDNA is unique, since it has homology to exon 1A of hPTHrP which suggests that dogs utilize a promoter similar to P1 of hPTHrP which has not been demonstrated in other species. ..