Genomes and Genes
Experts and Doctors on oxygen in United Kingdom
Locale: United Kingdom
Publications168 found, 100 shown here
- Tobler P, Fletcher P, Bullmore E, Schultz W. Learning-related human brain activations reflecting individual finances. Neuron. 2007;54:167-75 pubmed..The inverse relationship of behavioral and neuronal learning speed with personal finances is compatible with the general concept of decreasing marginal utility with increasing wealth. ..
- Waldron S, Scott E, Soulsby C. Stable isotope analysis reveals lower-order river dissolved inorganic carbon pools are highly dynamic. Environ Sci Technol. 2007;41:6156-62 pubmed..This approach is powerful for assessing whether the dynamic response exhibited here is ubiquitous in other fluvial systems at the terrestrial-aquatic interface or in larger catchments. ..
- Gupta A, Hutchinson P, Al Rawi P, Gupta S, Swart M, Kirkpatrick P, et al. Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury. Anesth Analg. 1999;88:549-53 pubmed..We compared this method with measurement of brain tissue oxygenation using a multiparameter sensor inserted into brain tissue. The brain tissue monitor seemed to reflect regional brain oxygenation better than jugular bulb oximetry. ..
- Lemieux L, Krakow K, Fish D. Comparison of spike-triggered functional MRI BOLD activation and EEG dipole model localization. Neuroimage. 2001;14:1097-104 pubmed
- Maddock H, Mocanu M, Yellon D. Adenosine A(3) receptor activation protects the myocardium from reperfusion/reoxygenation injury. Am J Physiol Heart Circ Physiol. 2002;283:H1307-13 pubmed..This is the first study to demonstrate that A(3)R activation at reperfusion limits myocardial injury in the isolated rat heart and improves survival in isolated myocytes, possibly by antiapoptotic and antinecrotic mechanisms. ..
- Forsyth N, McWhir J. Human embryonic stem cell telomere length impacts directly on clonal progenitor isolation frequency. Rejuvenation Res. 2008;11:5-17 pubmed..In summary we describe the derivation of clonal progenitor cells from human embryonic stem cells and the relevance of parental cell telomere length to the frequency of highly proliferative clone isolation. ..
- Passamonti L, Rowe J, Schwarzbauer C, Ewbank M, von dem Hagen E, Calder A. Personality predicts the brain's response to viewing appetizing foods: the neural basis of a risk factor for overeating. J Neurosci. 2009;29:43-51 pubmed publisher..Differences in the dynamic interactions within the human appetitive network in response to pictures of appetizing foods may determine an individual's risk of obesity. ..
- Thorn C, Matcher S, Meglinski I, Shore A. Is mean blood saturation a useful marker of tissue oxygenation?. Am J Physiol Heart Circ Physiol. 2009;296:H1289-95 pubmed publisher..S(mb)O(2) alone cannot therefore be accepted as a definitive marker of tissue oxygenation. ..
- Pattinson K, Governo R, MacIntosh B, Russell E, Corfield D, Tracey I, et al. Opioids depress cortical centers responsible for the volitional control of respiration. J Neurosci. 2009;29:8177-86 pubmed publisher..Opioids have profound effects on the cortical centers that control breathing, which potentiates their actions in the brainstem. ..
- Schneider S, Pleger B, Draganski B, Cordivari C, Rothwell J, Bhatia K, et al. Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia--an fMRI-TMS study. Mov Disord. 2010;25:76-83 pubmed publisher..Alternatively, the increased BG activation seen in the baseline state without rTMS may reflect a compensatory strategy that saturates a BG contribution to this task. ..
- Pires I, Bencokova Z, Milani M, Folkes L, Li J, Stratford M, et al. Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Res. 2010;70:925-35 pubmed publisher..Our findings suggest that cells lacking functional p53 are more susceptible to genomic instability and potentially tumorigenesis if they experience reoxygenation after acute exposure to hypoxia. ..
- Olcina M, Lecane P, Hammond E. Targeting hypoxic cells through the DNA damage response. Clin Cancer Res. 2010;16:5624-9 pubmed publisher..In this situation, phosphorylation of H2AX has been shown to be required for proliferation and angiogenesis and is, therefore, an attractive potential therapeutic target. ..
- Mavridou D, Ferguson S, Stevens J. The interplay between the disulfide bond formation pathway and cytochrome c maturation in Escherichia coli. FEBS Lett. 2012;586:1702-7 pubmed publisher..We also prove that DsbD is important but not essential for maturation of c-type cytochromes. We discuss the findings in the context of a model in which heme attachment to, and oxidation of, the apocytochrome are competing processes. ..
- Yoshida W, Seymour B, Koltzenburg M, Dolan R. Uncertainty increases pain: evidence for a novel mechanism of pain modulation involving the periaqueductal gray. J Neurosci. 2013;33:5638-46 pubmed publisher..Our results provide evidence for a novel form of cognitive hyperalgesia relating to perceptual uncertainty, induced here by vicarious observation, with control mediated by the brainstem pain modulatory system. ..
- Couto A, Oda S, Nikolaev V, Soltesz Z, de Bono M. In vivo genetic dissection of O2-evoked cGMP dynamics in a Caenorhabditis elegans gas sensor. Proc Natl Acad Sci U S A. 2013;110:E3301-10 pubmed publisher..This variability may reflect stochastic differences in expression of cGMP signaling components. Our work provides in vivo insights into the architecture of neuronal cGMP signaling. ..
- O Reilly V, Lopes Floro K, Shi H, Chapman B, Preis J, James A, et al. Gene-environment interaction demonstrates the vulnerability of the embryonic heart. Dev Biol. 2014;391:99-110 pubmed publisher..Importantly, these findings extend our understanding of the roles of Hif1Î± in cardiovascular development. ..
- Marcos J, Hornero R, Nabney I, Ãlvarez D, GutiÃ©rrez Tobal G, Del Campo F. Regularity analysis of nocturnal oximetry recordings to assist in the diagnosis of sleep apnoea syndrome. Med Eng Phys. 2016;38:216-24 pubmed publisher..Furthermore, KEn represents a convincing alternative to AEn and SEn for the diagnostic analysis of noisy biomedical signals. ..
- Cross R, Lloyd D, Poole R, Moir J. Enzymatic removal of nitric oxide catalyzed by cytochrome c' in Rhodobacter capsulatus. J Bacteriol. 2001;183:3050-4 pubmed..The inhibition of respiratory oxidase activity of R. capsulatus by NO suggests that one role for cytochrome c' is to maintain oxidase activity when both NO and O(2) are present. ..
- Bai Z, Harvey L, McNeil B. Use of the chemiluminescent probe lucigenin to monitor the production of the superoxide anion radical in a recombinant Aspergillus niger (B1-D). Biotechnol Bioeng. 2001;75:204-11 pubmed..These results show that lucigenin may be used as a convenient chemiluminescent probe to monitor intracellular production of O(2)(.-) in filamentous fungi, and thus to follow changes in the level of this stressor within fungi ..
- Hyun D, Lee M, Hattori N, Kubo S, Mizuno Y, Halliwell B, et al. Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome. J Biol Chem. 2002;277:28572-7 pubmed..The presence of mutant Parkin in substantia nigra in juvenile parkinsonism may increase oxidative stress and nitric oxide production, sensitizing cells to death induced by other insults. ..
- Ehrsson H, Holmes N, Passingham R. Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areas. J Neurosci. 2005;25:10564-73 pubmed..We propose that this could be the mechanism for the feeling of body ownership. ..
- Browning J, Staines H, Robinson H, Powell T, Ellory J, Gibson J. The effect of deoxygenation on whole-cell conductance of red blood cells from healthy individuals and patients with sickle cell disease. Blood. 2007;109:2622-9 pubmed..These findings represent the first electrical recordings of single HbS cells and will facilitate progress in understanding altered red blood cell cation transport characteristics of SCD. ..
- Latifi R, Bagherzadeh M, Milne B, Jaspars M, de Visser S. Density functional theory studies of oxygen and carbonate binding to a dicopper patellamide complex. J Inorg Biochem. 2008;102:2171-8 pubmed publisher..Alternatively, carbonate may act as an inhibitor that blocks the catalytic activity of the system. It is anticipated that the Cu2(mu-O)2-patellamide structure is a potential active oxidant of the dicopper patellamide complex. ..
- Bueti D, Bahrami B, Walsh V, Rees G. Encoding of temporal probabilities in the human brain. J Neurosci. 2010;30:4343-52 pubmed publisher..Moreover, we show that activity in those areas changes dynamically in a manner that closely accords with temporal expectations. ..
- Formenti F, Constantin Teodosiu D, Emmanuel Y, Cheeseman J, Dorrington K, Edwards L, et al. Regulation of human metabolism by hypoxia-inducible factor. Proc Natl Acad Sci U S A. 2010;107:12722-7 pubmed publisher..These findings have significant implications for the development of therapeutic approaches targeting the HIF pathway. ..
- Staresina B, Duncan K, Davachi L. Perirhinal and parahippocampal cortices differentially contribute to later recollection of object- and scene-related event details. J Neurosci. 2011;31:8739-47 pubmed publisher..In sum, these results strongly point to representational domain as a key factor determining the involvement of different MTLC subregions during successful episodic memory formation. ..
- Di Pietro R, Fazzi D, Kehoe T, Sirringhaus H. Spectroscopic investigation of oxygen- and water-induced electron trapping and charge transport instabilities in n-type polymer semiconductors. J Am Chem Soc. 2012;134:14877-89 pubmed publisher..The degradation mechanisms identified here should be considered to explain electron trapping in other rylene diimides and possibly in other classes of conjugated polymers as well. ..
- de Visser S, Porro C, Quesne M, Sainna M, Munro A. Overview on theoretical studies discriminating the two-oxidant versus two-state-reactivity models for substrate monoxygenation by cytochrome P450 enzymes. Curr Top Med Chem. 2013;13:2218-32 pubmed..This review will give an overview of recent studies on the two-oxidant versus two-state-reactivity hypotheses and how theory contributes to the understanding of enzymatic reaction processes. ..
- Forte E, Borisov V, Falabella M, Colaço H, Tinajero Trejo M, Poole R, et al. The Terminal Oxidase Cytochrome bd Promotes Sulfide-resistant Bacterial Respiration and Growth. Sci Rep. 2016;6:23788 pubmed publisher..We conclude that bd oxidases promote sulfide-resistant O2-consumption and growth in E. coli and possibly other bacteria. The impact of this discovery is discussed. ..
- Bai Z, Harvey L, McNeil B. Physiological responses of chemostat cultures of Aspergillus niger (B1-D) to simulated and actual oxidative stress. Biotechnol Bioeng. 2003;82:691-701 pubmed..The dynamic culture response was characterized by rapid elevation of intracellular superoxide anions and associated protective enzymes, especially SOD, and was clearly distinct from the adaptive response just described. ..
- Chen J, Stoeber K, Kingsbury S, Ozanne S, Williams G, Hales C. Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J Biol Chem. 2004;279:49439-46 pubmed..Our data suggest that loss of proliferative capacity in oxidatively stressed cells is a multistep process regulated by time-dependent molecular events that may play differential roles in induction and maintenance of cellular senescence. ..
- Cannan S, Zhang J, Grunfeld F, Unwin P. Scanning electrochemical microscopy (SECM) studies of oxygen transfer across phospholipid monolayers under surface pressure control: comparison of monolayers at air/water and oil/water interfaces. Langmuir. 2004;20:701-7 pubmed..The results obtained for each interface are compared, and the implications for studies of passive diffusion across cell membranes are discussed. ..
- Goldet G, Wait A, Cracknell J, Vincent K, Ludwig M, Lenz O, et al. Hydrogen production under aerobic conditions by membrane-bound hydrogenases from Ralstonia species. J Am Chem Soc. 2008;130:11106-13 pubmed publisher..Consequently, H2 can be produced sustainably in the presence of O2 as long as the H2 is removed continuously, thereby proving the feasibility for biological H2 production in air...
- Vijayan R, Plested A, Mayer M, Biggin P. Selectivity and cooperativity of modulatory ions in a neurotransmitter receptor. Biophys J. 2009;96:1751-60 pubmed publisher..Furthermore, using a potential of mean force derived from umbrella sampling, we show that the presence of cations lower the energy barrier for anion approach and binding in the buried anion binding cavity...
- Viard A, Doeller C, Hartley T, Bird C, Burgess N. Anterior hippocampus and goal-directed spatial decision making. J Neurosci. 2011;31:4613-21 pubmed publisher..They illustrate how spatial and nonspatial functions combine within the anterior hippocampus, and how these functions interact with parahippocampal, parietal, and prefrontal areas in decision making and mnemonic function. ..
- Carhart Harris R, Erritzoe D, Williams T, Stone J, Reed L, Colasanti A, et al. Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proc Natl Acad Sci U S A. 2012;109:2138-43 pubmed publisher..These results strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition. ..
- Milner P, Smith H, Robinson R, Wilkins R, Gibson J. Growth factor regulation of intracellular pH homeostasis under hypoxic conditions in isolated equine articular chondrocytes. J Orthop Res. 2013;31:197-203 pubmed publisher..These results show that oxygen and growth factors interact to regulate pH recovery in articular chondrocytes by modulating intracellular oxygen metabolites. ..
- Ramsey R, Hansen P, Apperly I, Samson D. Seeing it my way or your way: frontoparietal brain areas sustain viewpoint-independent perspective selection processes. J Cogn Neurosci. 2013;25:670-84 pubmed publisher..In doing so, we provide stronger evidence for the claim that we not only automatically compute what other people see but also, in some cases, we compute this even before we are explicitly aware of our own perspective. ..
- Partridge J, Sanguinetti G, Dibden D, Roberts R, Poole R, Green J. Transition of Escherichia coli from aerobic to micro-aerobic conditions involves fast and slow reacting regulatory components. J Biol Chem. 2007;282:11230-7 pubmed
- Zervou S, Whittington H, Ostrowski P, Cao F, Tyler J, Lake H, et al. Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro. PLoS ONE. 2017;12:e0182994 pubmed publisher..These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 in a cardiac-relevant cell line, which merits further investigation in vivo. ..
- Linden D, Oosterhof N, Klein C, Downing P. Mapping brain activation and information during category-specific visual working memory. J Neurophysiol. 2012;107:628-39 pubmed publisher..We also confirm previous findings that MVPA can extract information from fMRI signals in the absence of suprathreshold activation and that such signals from visual areas can reflect the material stored in memory. ..
- Weber C, O Regan D, Hine N, Littlewood P, Kotliar G, Payne M. Importance of many-body effects in the Kernel of hemoglobin for ligand binding. Phys Rev Lett. 2013;110:106402 pubmed
- Kidambi P, Bayer B, Blume R, Wang Z, Baehtz C, Weatherup R, et al. Observing graphene grow: catalyst-graphene interactions during scalable graphene growth on polycrystalline copper. Nano Lett. 2013;13:4769-78 pubmed publisher..The importance of these dynamic interactions is discussed for graphene growth, processing, and device integration. ..
- Parra M, Della Sala S, Logie R, Morcom A. Neural correlates of shape-color binding in visual working memory. Neuropsychologia. 2014;52:27-36 pubmed publisher..Our findings suggest that both individual features and their binding within integrated objects are used to represent complex objects in WM. ..
- Membrillo Hernandez J, Coopamah M, Anjum M, Stevanin T, Kelly A, Hughes M, et al. The flavohemoglobin of Escherichia coli confers resistance to a nitrosating agent, a "Nitric oxide Releaser," and paraquat and is essential for transcriptional responses to oxidative stress. J Biol Chem. 1999;274:748-54 pubmed..This protective role probably involves direct detoxification of those species and sensing of NO-related and oxidative stress. ..
- Zajicek R, Cheesman M, Gordon E, Ferguson S. Y25S variant of Paracoccus pantotrophus cytochrome cd1 provides insight into anion binding by d1 heme and a rare example of a critical difference between solution and crystal structures. J Biol Chem. 2005;280:26073-9 pubmed
- Gong M, Hay S, Marshall K, Munro A, Scrutton N. DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis. J Biol Chem. 2007;282:30331-40 pubmed..Through its DNA binding activity, we suggest that AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro)viral) cytosolic DNA, thus contributing to the onset of apoptosis. ..
- Jawad N, Rizvi M, Gu J, Adeyi O, Tao G, Maze M, et al. Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury. Neurosci Lett. 2009;460:232-6 pubmed publisher..84+/-0.09 (p<0.01), but argon showed an improvement in reducing ability to 1.15+/-0.11 (p<0.05). Our data suggest that the cheap and widely available noble gas argon may have potential as a neuroprotectant for the future...
- Wu C, Zou Q, Xue S, Pan W, Huang L, Hartley W, et al. The effect of silicon on iron plaque formation and arsenic accumulation in rice genotypes with different radial oxygen loss (ROL). Environ Pollut. 2016;212:27-33 pubmed publisher..Rice of indica genotypes with higher ROL accumulated lower concentrations of inorganic As in grains than hybrid genotypes with lower ROL. ..
- Gallen I, Macdonald I. Effect of two methods of hand heating on body temperature, forearm blood flow, and deep venous oxygen saturation. Am J Physiol. 1990;259:E639-43 pubmed..0%, P less than 0.01) but was not greater than control with either method of hand heating. We conclude that using a warm-air box has less effect than a heated blanket on the measured variables. ..
- Bretscher A, Busch K, de Bono M. A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008;105:8044-9 pubmed publisher..Food and allelic variation at NPR-1 regulate which response prevails. Our results suggest that multiple sensory inputs are coordinated by C. elegans to generate different coherent foraging strategies. ..
- Lang H, Cogdell R, Gardiner A, Hunter C. Early steps in carotenoid biosynthesis: sequences and transcriptional analysis of the crtI and crtB genes of Rhodobacter sphaeroides and overexpression and reactivation of crtI in Escherichia coli and R. sphaeroides. J Bacteriol. 1994;176:3859-69 pubmed..In this report, we have located the transcription initiation point and have shown that R. sphaeroides possesses an oxygen-regulated CrtI-type phytoene desaturase gene that forms a transcriptional operon with crtB...
- Butler P, Jones D. Physiology of diving of birds and mammals. Physiol Rev. 1997;77:837-99 pubmed..Efferent cardiac control is largely parasympathetic. Reflex cardiorespiratory responses are modulated by conditioning and habituation, but reflexes predominate during extended dives and during recovery, when gas exchange is maximized. ..
- Epstein A, Gleadle J, McNeill L, Hewitson K, O ROURKE J, Mole D, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001;107:43-54 pubmed
- Nagel O, Waldron S, Jones H. An off-line implementation of the stable isotope technique for measurements of alternative respiratory pathway activities. Plant Physiol. 2001;127:1279-86 pubmed..Our method provides results similar to those obtained with laboratory incubations on-line to a mass spectrometer but greatly increases the potential for adoption of the stable isotope method. ..
- Rosin C, Colombo S, Calver A, Bates T, Skaper S. Dopamine D2 and D3 receptor agonists limit oligodendrocyte injury caused by glutamate oxidative stress and oxygen/glucose deprivation. Glia. 2005;52:336-43 pubmed..Our results suggest that dopamine D2 and D3 receptor activation may play an important role in oligodendrocyte protection against oxidative glutamate toxicity and oxygen-glucose deprivation injury. ..
- Crack J, Green J, Le Brun N, Thomson A. Detection of sulfide release from the oxygen-sensing [4Fe-4S] cluster of FNR. J Biol Chem. 2006;281:18909-13 pubmed..This demonstrates that the reaction between O2 and the [4Fe-4S]2+ cluster does not require sulfide oxidation and hence must entail iron oxidation. ..
- Crack J, Green J, Cheesman M, Le Brun N, Thomson A. Superoxide-mediated amplification of the oxygen-induced switch from [4Fe-4S] to [2Fe-2S] clusters in the transcriptional regulator FNR. Proc Natl Acad Sci U S A. 2007;104:2092-7 pubmed..This mechanism, a one electron activation of the cluster, coupled to catalytic recycling of the resulting superoxide ion back to oxygen, provides a means of amplifying the sensitivity of [4Fe-4S] FNR to its signal molecule. ..
- Giessing C, Thiel C, Alexander Bloch A, Patel A, Bullmore E. Human brain functional network changes associated with enhanced and impaired attentional task performance. J Neurosci. 2013;33:5903-14 pubmed publisher..They also demonstrate that brain network analysis can provide novel and theoretically principled pharmacodynamic biomarkers of pro-cognitive drug effects in humans. ..
- Cadenas S, Echtay K, Harper J, Jekabsons M, Buckingham J, Grau E, et al. The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J Biol Chem. 2002;277:2773-8 pubmed..We conclude that uncoupling in UCP3-tg mice is an artifact of transgenic expression, and that UCP3 does not catalyze the basal proton conductance of skeletal muscle mitochondria in the absence of activators such as superoxide. ..
- Kanu N, Penicud K, Hristova M, Wong B, Irvine E, Plattner F, et al. The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem. 2010;285:38534-42 pubmed publisher..These results suggest that ATMIN mediates ATM activation by oxidative stress, and thereby ATMIN protects the aging brain by preventing accumulation of DNA damage. ..
- Jozwik K, Kriegeskorte N, Mur M. Visual features as stepping stones toward semantics: Explaining object similarity in IT and perception with non-negative least squares. Neuropsychologia. 2016;83:201-226 pubmed publisher..Similarity judgments contain additional categorical variance that is not explained by visual features, reflecting a higher-level more purely semantic representation. ..
- Evans A, Mustard K, Wyatt C, Peers C, Dipp M, Kumar P, et al. Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?. J Biol Chem. 2005;280:41504-11 pubmed..Thus, metabolic sensing by AMP-activated protein kinase may mediate chemotransduction by hypoxia. ..
- Deol S, Domene C, Bond P, Sansom M. Anionic phospholipid interactions with the potassium channel KcsA: simulation studies. Biophys J. 2006;90:822-30 pubmed publisher..Overall, this study suggests that simulations can help identify and characterize sites for specific lipid interactions on a membrane protein surface...
- Horsefield R, Yankovskaya V, Sexton G, Whittingham W, Shiomi K, Omura S, et al. Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. J Biol Chem. 2006;281:7309-16 pubmed..This allows us to propose a mechanism for the reduction of ubiquinone during the catalytic turnover of the enzyme. ..
- Ullah M, Davies A, Halestrap A. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem. 2006;281:9030-7 pubmed..We conclude that MCT4, like other glycolytic enzymes, is up-regulated by hypoxia through a HIF-1alpha-mediated mechanism. This adaptive response allows the increased lactic acid produced during hypoxia to be rapidly lost from the cell. ..
- Lam Y, Atkinson J. Biomedical sensor using thick film technology for transcutaneous oxygen measurement. Med Eng Phys. 2007;29:291-7 pubmed..This study has greatly contributed towards the understanding for the suitability of the materials in achieving a viable, low-cost biomedical sensor. ..
- Gibson J, Ellory J. Membrane transport in sickle cell disease. Blood Cells Mol Dis. 2002;28:303-14 pubmed..A model for sickle cell dehydration is presented. Inhibition of these permeability changes represents possible avenues for future chemotherapy to ameliorate the condition. ..
- Lloyd M, Lipscomb S, Hewitson K, Hensgens C, Baldwin J, Schofield C. Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase. J Biol Chem. 2004;279:15420-6 pubmed..The catalytic efficiency of mutant enzymes can be improved by combining active site mutations with other modifications including C-terminal truncation and modification of Asn-305. ..
- Lanigan G, Betson N, Griffiths H, Seibt U. Carbon isotope fractionation during photorespiration and carboxylation in Senecio. Plant Physiol. 2008;148:2013-20 pubmed publisher..Our results emphasize that the effects of photorespiration must be taken into account when partitioning net CO(2) exchange of ecosystems into gross fluxes of photosynthesis and respiration...
- Hall C, Klein Flügge M, Howarth C, Attwell D. Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing. J Neurosci. 2012;32:8940-51 pubmed publisher..Thus, the major mechanisms mediating brain information processing are all initially powered by oxidative phosphorylation, and an astrocyte-neuron lactate shuttle is not needed for this to occur. ..
- Huang X, Rein G. Thermochemical conversion of biomass in smouldering combustion across scales: The roles of heterogeneous kinetics, oxygen and transport phenomena. Bioresour Technol. 2016;207:409-21 pubmed publisher..This is the first time that the influence of oxygen on biomass smouldering is explained in terms of both chemistry and transport phenomena across scales. ..
- Farmery A, Hahn C. Response-time enhancement of a clinical gas analyzer facilitates measurement of breath-by-breath gas exchange. J Appl Physiol (1985). 2000;89:581-9 pubmed..With the use of this technique, measurements required for non-steady-state and tidal gas-exchange models can be made easily and reliably in the clinical setting...
- Stillman T, Connolly P, Latimer C, Morland A, Quail M, Andrews S, et al. Insights into the effects on metal binding of the systematic substitution of five key glutamate ligands in the ferritin of Escherichia coli. J Biol Chem. 2003;278:26275-86 pubmed..The transient binding of Fe2+ at one of three newly observed Zn2+ sites may allow the oxidation of four Fe2+ by one dioxygen molecule. ..
- Constantinidou C, Hobman J, Griffiths L, Patel M, Penn C, Cole J, et al. A reassessment of the FNR regulon and transcriptomic analysis of the effects of nitrate, nitrite, NarXL, and NarQP as Escherichia coli K12 adapts from aerobic to anaerobic growth. J Biol Chem. 2006;281:4802-15 pubmed..This is the first report that NarP might function as a global repressor as well as a transcription activator. The data also revealed possible new defense mechanisms against reactive nitrogen species. ..
- Subramanian L, Hindle J, Johnston S, Roberts M, Husain M, Goebel R, et al. Real-time functional magnetic resonance imaging neurofeedback for treatment of Parkinson's disease. J Neurosci. 2011;31:16309-17 pubmed publisher..These findings demonstrate that self-modulation of cortico-subcortical motor circuits can be achieved by PD patients through neurofeedback and may result in clinical benefits that are not attainable by motor imagery alone. ..
- Murray A. Oxygen delivery and fetal-placental growth: beyond a question of supply and demand?. Placenta. 2012;33 Suppl 2:e16-22 pubmed publisher..Much remains unknown about the coordinated metabolic response of the fetal-placental unit to chronic hypoxia and oxidative stress, but it would appear to be more than a simple question of supply and demand. ..
- Longden T, Dabertrand F, Hill Eubanks D, Hammack S, Nelson M. Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K+ channel function. Proc Natl Acad Sci U S A. 2014;111:7462-7 pubmed publisher..Because the fidelity of NVC is essential for neuronal health, the impairment characterized here may contribute to the pathophysiology of brain disorders with a stress component. ..
- Park C, Payne S. Modelling the effects of cerebral microvasculature morphology on oxygen transport. Med Eng Phys. 2016;38:41-7 pubmed publisher..They thus open up the possibility of obtaining additional valuable clinical information for diagnosing and treating cerebrovascular diseases. ..
- Wientjes F, Reeves E, Soskic V, Furthmayr H, Segal A. The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain. Biochem Biophys Res Commun. 2001;289:382-8 pubmed..Furthermore, we show that its N-terminal part binds to the PX domain of p47phox and p40phox. ..
- Sarcina M, Bouzovitis N, Mullineaux C. Mobilization of photosystem II induced by intense red light in the Cyanobacterium Synechococcus sp PCC7942. Plant Cell. 2006;18:457-64 pubmed..The localized concentrations of photosystem II seen after red light treatment may correspond to specific zones where the repair cycle is active. ..