Genomes and Genes
Experts and Doctors on oxidoreductases in France
Publications167 found, 100 shown here
- Caira F, Clemencet M, Cherkaoui Malki M, Dieuaide Noubhani M, Pacot C, Van Veldhoven P, et al. Differential regulation by a peroxisome proliferator of the different multifunctional proteins in guinea pig: cDNA cloning of the guinea pig D-specific multifunctional protein 2. Biochem J. 1998;330 ( Pt 3):1361-8 pubmed..This paper is the first, to our knowledge, reporting the down-regulation of the expression of genes encoding enzymes involved in the peroxisomal beta-oxidation of fatty acids (MFP-1) and bile acid synthesis (MFP-2) in mammals. ..
- Brown K, Djinovic Carugo K, Haltia T, Cabrito I, Saraste M, Moura J, et al. Revisiting the catalytic CuZ cluster of nitrous oxide (N2O) reductase. Evidence of a bridging inorganic sulfur. J Biol Chem. 2000;275:41133-6 pubmed..This result reconciles the novel CuZ cluster with the hitherto puzzling spectroscopic data. ..
- Lautru S, Gondry M, Genet R, Pernodet J. The albonoursin gene Cluster of S noursei biosynthesis of diketopiperazine metabolites independent of nonribosomal peptide synthetases. Chem Biol. 2002;9:1355-64 pubmed
- Lastres Becker I, Bizat N, Boyer F, Hantraye P, Brouillet E, Fernandez Ruiz J. Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate. Neuroreport. 2003;14:813-6 pubmed
- Commo S, Gaillard O, Thibaut S, Thibaut S, Bernard B. Absence of TRP-2 in melanogenic melanocytes of human hair. Pigment Cell Res. 2004;17:488-97 pubmed..According to the absence of TRP-2 in melanin-producing melanocytes of brown and black hair bulbs, one must consider that eumelanogenesis as well as brown and black colour do not require TRP-2 expression in human hair. ..
- Mathé C, Niviere V, Mattioli T. Fe3+-hydroxide ligation in the superoxide reductase from Desulfoarculus baarsii is associated with pH dependent spectral changes. J Am Chem Soc. 2005;127:16436-41 pubmed..With respect to our previous work, B- can be identified with this high-spin Fe3+-OH species, which upon protonation results in a water molecule at the active site. Implications for the SOR catalytic cycle are proposed. ..
- Lanciano P, Magalon A, Bertrand P, Guigliarelli B, Grimaldi S. High-stability semiquinone intermediate in nitrate reductase A (NarGHI) from Escherichia coli is located in a quinol oxidation site close to heme bD. Biochemistry. 2007;46:5323-9 pubmed..Overall, our results indicate that the semiquinone is located within the quinol oxidation site QD. Details of the possible binding motif of the semiquinone and mechanistic implications are discussed. ..
- Veyron Churlet R, Zanella Cleon I, Cohen Gonsaud M, Molle V, Kremer L. Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis. J Biol Chem. 2010;285:12714-25 pubmed publisher..This study provides the first information on the molecular mechanism(s) involved in mycolic acid regulation through Ser/Thr protein kinase-dependent phosphorylation of a type II fatty acid synthase enzyme. ..
- Grienenberger E, Kim S, Lallemand B, Geoffroy P, Heintz D, Souza C, et al. Analysis of TETRAKETIDE ?-PYRONE REDUCTASE function in Arabidopsis thaliana reveals a previously unknown, but conserved, biochemical pathway in sporopollenin monomer biosynthesis. Plant Cell. 2010;22:4067-83 pubmed publisher..TKPR activities, together with those of ACOS5 and PKSA/B, identify a conserved biosynthetic pathway leading to hydroxylated ?-pyrone compounds that were previously unknown to be sporopollenin precursors. ..
- Galzerano D, Feilke K, Schaub P, Beyer P, Krieger Liszkay A. Effect of constitutive expression of bacterial phytoene desaturase CRTI on photosynthetic electron transport in Arabidopsis thaliana. Biochim Biophys Acta. 2014;1837:345-53 pubmed publisher..We propose that PTOX competes efficiently with cyclic electron flow for plastoquinol in the CRTI-expressing lines and that it plays a crucial role in the control of the reduction state of the plastoquinone pool...
- Abergel C, Coutard B, Byrne D, Chenivesse S, Claude J, Deregnaucourt C, et al. Structural genomics of highly conserved microbial genes of unknown function in search of new antibacterial targets. J Struct Funct Genomics. 2003;4:141-57 pubmed
- Sigoillot C, Camarero S, Vidal T, Record E, Asther M, Pérez Boada M, et al. Comparison of different fungal enzymes for bleaching high-quality paper pulps. J Biotechnol. 2005;115:333-43 pubmed..The good results obtained with the same laccase expressed in A. niger at bioreactor scale, revealed the feasibility of using recombinant laccase for bleaching high-quality non-wood pulps in the presence of a mediator. ..
- Malarte G, Leroy G, Lojou E, Abergel C, Bruschi M, Giudici Orticoni M. Insight into molecular stability and physiological properties of the diheme cytochrome CYC41 from the acidophilic bacterium Acidithiobacillus ferrooxidans. Biochemistry. 2005;44:6471-81 pubmed..A docking analysis of CYC(41), RCy, and cytochrome oxidase allowed us to propose a model for the complex in agreement with our experimental data...
- Vieira Dos Santos C, Cuiné S, Rouhier N, Rey P. The Arabidopsis plastidic methionine sulfoxide reductase B proteins. Sequence and activity characteristics, comparison of the expression with plastidic methionine sulfoxide reductase A, and induction by photooxidative stress. Plant Physiol. 2005;138:909-22 pubmed..The possible role of plastidic MsrB in the tolerance to oxidative damage is discussed. ..
- Janthawornpong K, Krasutsky S, Chaignon P, Rohmer M, Poulter C, Seemann M. Inhibition of IspH, a [4Fe-4S]2+ enzyme involved in the biosynthesis of isoprenoids via the methylerythritol phosphate pathway. J Am Chem Soc. 2013;135:1816-22 pubmed publisher..The slow binding behavior of this inhibitor is best described by a one-step mechanism with the slow step consisting of the formation of the enzyme-inhibitor (EI) complex. ..
- Zagorec M, Buhler J, Treich I, Keng T, Guarente L, Labbe Bois R. Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase. J Biol Chem. 1988;263:9718-24 pubmed..The loss of induction of coproporphyrinogen oxidase activity by anaerobiosis caused a considerable decrease of heme formation in anaerobic cells. ..
- Malki S, Saimmaime I, De Luca G, Rousset M, Dermoun Z, Belaich J. Characterization of an operon encoding an NADP-reducing hydrogenase in Desulfovibrio fructosovorans. J Bacteriol. 1995;177:2628-36 pubmed..This H(2)-dependent NADP reductase activity disappeared completely in extracts from SM3. These results indicate that the hnd operon actually encodes an NAdP-reducing hydrogenase in D. fructosovorans...
- Zaka R, Vandecasteele C, Misset M. Effects of low chronic doses of ionizing radiation on antioxidant enzymes and G6PDH activities in Stipa capillata (Poaceae). J Exp Bot. 2002;53:1979-87 pubmed
- Mairet Coello G, Tury A, Fellmann D, Jouvenot M, Griffond B. Expression of SOx-2, a member of the FAD-dependent sulfhydryl oxidase/quiescin Q6 gene family, in rat brain. Neuroreport. 2002;13:2049-51 pubmed..The finding of gene expression in brain is relevant, since its dysregulation could lead to oxidative stress, a causative factor in the pathogenesis of neurodegenerative diseases. ..
- Rosenfeld E, Beauvoit B. Role of the non-respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae. Yeast. 2003;20:1115-44 pubmed..Finally, several aspects of oxygen sensing are discussed. ..
- Lorin S, Dufour E, Sainsard Chanet A. Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina. Biochim Biophys Acta. 2006;1757:604-10 pubmed..anserina for studying lifespan regulation...
- Merkamm M, Guyonvarch A. Cloning of the sodA gene from Corynebacterium melassecola and role of superoxide dismutase in cellular viability. J Bacteriol. 2001;183:1284-95 pubmed publisher..Surprisingly, SOD deficiency was able to rescue the dramatic loss of viability observed for the wild-type strain in BMCG synthetic medium when glucose was not the limiting growth factor...
- Mathé C, Mattioli T, Horner O, Lombard M, Latour J, Fontecave M, et al. Identification of iron(III) peroxo species in the active site of the superoxide reductase SOR from Desulfoarculus baarsii. J Am Chem Soc. 2002;124:4966-7 pubmed..These data support the hypothesis that the reaction of SOR proceeds through such a Fe3+-peroxo intermediate. This also suggests that Glu47 might serve to help H2O2 release during the reaction with superoxide. ..
- Horner O, Mouesca J, Oddou J, Jeandey C, Niviere V, Mattioli T, et al. Mössbauer characterization of an unusual high-spin side-on peroxo-Fe3+ species in the active site of superoxide reductase from Desulfoarculus Baarsii. Density functional calculations on related models. Biochemistry. 2004;43:8815-25 pubmed..58 mm/s range. The occurrence of a side-on peroxo intermediate in SOR is discussed in relation to the recent data published for a side-on peroxo-Fe(3+) species in another biological system [Karlsson et al. (2003) Science 299, 1039-1042]. ..
- Ezraty B, Aussel L, Barras F. Methionine sulfoxide reductases in prokaryotes. Biochim Biophys Acta. 2005;1703:221-9 pubmed
- Picot C, Petropoulos I, Perichon M, Moreau M, Nizard C, Friguet B. Overexpression of MsrA protects WI-38 SV40 human fibroblasts against H2O2-mediated oxidative stress. Free Radic Biol Med. 2005;39:1332-41 pubmed
- Tarrago L, Laugier E, Zaffagnini M, Marchand C, Le Marechal P, Rouhier N, et al. Regeneration mechanisms of Arabidopsis thaliana methionine sulfoxide reductases B by glutaredoxins and thioredoxins. J Biol Chem. 2009;284:18963-71 pubmed publisher..This study proposes a detailed mechanism of the regeneration of 1-Cys MSRB activity by glutaredoxins, which likely constitute physiological reductants for this type of MSR. ..
- Quéméneur M, Cébron A, Billard P, Battaglia Brunet F, Garrido F, Leyval C, et al. Population structure and abundance of arsenite-oxidizing bacteria along an arsenic pollution gradient in waters of the upper isle River Basin, France. Appl Environ Microbiol. 2010;76:4566-70 pubmed publisher..The highest aoxB gene densities were found in the most As-polluted oxic surface waters but without any significant correlation with environmental factors. Arsenite oxidizers seem to play a key role in As mobility in As-impacted waters. ..
- Muhlenhoff U, Molik S, Godoy J, Uzarska M, Richter N, Seubert A, et al. Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. Cell Metab. 2010;12:373-385 pubmed publisher..Collectively, our study uncovers an important role of monothiol glutaredoxins in cellular iron metabolism, with a surprising connection to cellular redox and sulfur metabolisms. ..
- Gibrat J, Madej T, Bryant S. Surprising similarities in structure comparison. Curr Opin Struct Biol. 1996;6:377-85 pubmed
- Masclaux F, Charpenteau M, Takahashi T, Pont Lezica R, Galaud J. Gene silencing using a heat-inducible RNAi system in Arabidopsis. Biochem Biophys Res Commun. 2004;321:364-9 pubmed..2 inducible promoter. ..
- Castelle C, Guiral M, Malarte G, Ledgham F, Leroy G, Brugna M, et al. A new iron-oxidizing/O2-reducing supercomplex spanning both inner and outer membranes, isolated from the extreme acidophile Acidithiobacillus ferrooxidans. J Biol Chem. 2008;283:25803-11 pubmed publisher..Besides the proteins involved in the O(2) reduction, there were additional proteins in the supercomplex, involved in uphill pathway (bc complex and cytochrome Cyc(42)), suggesting a possible physical link between these two pathways. ..
- Cournac L, Redding K, Ravenel J, Rumeau D, Josse E, Kuntz M, et al. Electron flow between photosystem II and oxygen in chloroplasts of photosystem I-deficient algae is mediated by a quinol oxidase involved in chlororespiration. J Biol Chem. 2000;275:17256-62 pubmed..Clues to the identity of the protein implied in this process are given by pharmacological and immunological similarities with a protein (IMMUTANS) identified in Arabidopsis chloroplasts. ..
- Katona G, Carpentier P, Niviere V, Amara P, Adam V, Ohana J, et al. Raman-assisted crystallography reveals end-on peroxide intermediates in a nonheme iron enzyme. Science. 2007;316:449-53 pubmed..The dynamic SOR active site promotes the formation of transient hydrogen bond networks, which presumably assist the cleavage of the iron-oxygen bond in order to release the reaction product, hydrogen peroxide. ..
- Gilot D, Migault M, Bachelot L, Journe F, Rogiers A, Donnou Fournet E, et al. A non-coding function of TYRP1 mRNA promotes melanoma growth. Nat Cell Biol. 2017;19:1348-1357 pubmed publisher..Together, our findings assign a pathogenic non-coding function to TYRP1 mRNA and highlight miRNA displacement as a promising targeted therapeutic approach for melanoma. ..
- Loisel Meyer S, Jiménez de Bagüés M, Basseres E, Dornand J, Kohler S, Liautard J, et al. Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection. Infect Immun. 2006;74:1973-6 pubmed..The norD strain exhibited attenuated multiplication within nitric oxide-producing murine macrophages and rapid elimination in mice, hence demonstrating that norD is essential for Brucella virulence...
- Ribon A, Pialoux V, Saugy J, Rupp T, Faiss R, Debevec T, et al. Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia. Respir Physiol Neurobiol. 2016;223:23-7 pubmed publisher..simulated altitude (NH) and that the chamber confinement (NN) did likely not explain these differences. ..
- Grimaud R, Ezraty B, Mitchell J, Lafitte D, Briand C, Derrick P, et al. Repair of oxidized proteins. Identification of a new methionine sulfoxide reductase. J Biol Chem. 2001;276:48915-20 pubmed publisher..A possibility is that these two ubiquitous methionine sulfoxide reductases exhibit different substrate specificity...
- Marcireau C, Guyonnet D, Karst F. Construction and growth properties of a yeast strain defective in sterol 14-reductase. Curr Genet. 1992;22:267-72 pubmed
- Carol P, Stevenson D, Bisanz C, Breitenbach J, Sandmann G, Mache R, et al. Mutations in the Arabidopsis gene IMMUTANS cause a variegated phenotype by inactivating a chloroplast terminal oxidase associated with phytoene desaturation. Plant Cell. 1999;11:57-68 pubmed..We propose a model in which IM function is linked to phytoene desaturation and, possibly, to the respiratory activity of the chloroplast. ..
- Philippot L. Denitrifying genes in bacterial and Archaeal genomes. Biochim Biophys Acta. 2002;1577:355-76 pubmed..In addition, some evolutionary relationships between the structural genes are presented. ..
- You C, Sekowska A, Francetic O, Martin Verstraete I, Wang Y, Danchin A. Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis. BMC Microbiol. 2008;8:128 pubmed publisher..The Spx mediated PQ-specific regulation pathway of the msrAB operon in B. subtilis is reported. Our results suggest that PQ induced the expression of msrAB partially through an oxidation on Spx via modification of its CXXC motif...
- Brasseur G, Levican G, Bonnefoy V, Holmes D, Jedlicki E, Lemesle Meunier D. Apparent redundancy of electron transfer pathways via bc(1) complexes and terminal oxidases in the extremophilic chemolithoautotrophic Acidithiobacillus ferrooxidans. Biochim Biophys Acta. 2004;1656:114-26 pubmed..A scheme for the electron transfer chains has been established that shows the existence of multiple respiratory routes to a single electron acceptor O(2). Possible reasons for these apparently redundant pathways are discussed. ..
- Massonneau A, Houba H rin N, Pethe C, Madzak C, Falque M, Mercy M, et al. Maize cytokinin oxidase genes: differential expression and cloning of two new cDNAs. J Exp Bot. 2004;55:2549-57 pubmed publisher..However, each gene had its own expression profile with a major difference concerning the onset of expression...
- Perucca Lostanlen D, Taylor R, Narbonne H, Mousson de Camaret B, Hayes C, Saunieres A, et al. Molecular and functional effects of the T14709C point mutation in the mitochondrial DNA of a patient with maternally inherited diabetes and deafness. Biochim Biophys Acta. 2002;1588:210-6 pubmed
- Ezraty B, Grimaud R, El Hassouni M, Moinier D, Barras F. Methionine sulfoxide reductases protect Ffh from oxidative damages in Escherichia coli. EMBO J. 2004;23:1868-77 pubmed..We conclude that MsrA and MsrB are required to repair Ffh oxidized by reactive oxygen species produced by aerobic metabolism, establishing an as-yet undescribed link between protein targeting and oxidation. ..
- Raffali F, Rougier A, Roguet R. Measurement and modulation of cytochrome-P450-dependent enzyme activity in cultured human keratinocytes. Skin Pharmacol. 1994;7:345-54 pubmed..In conclusion, this model appears to be useful for studying the biotransforming activity of human skin. It allows a rapid evaluation of the inducing/inhibitory effects of xenobiotics. ..
- Chanal A, Santini C, Wu L. Specific inhibition of the translocation of a subset of Escherichia coli TAT substrates by the TorA signal peptide. J Mol Biol. 2003;327:563-70 pubmed..These results demonstrated that the twin-arginine signal peptide of the TorA protein specifically inhibits the translocation of a subset of TAT substrates, probably at the step of their targeting to the TAT apparatus. ..
- Gugger M, Molica R, Le Berre B, Dufour P, Bernard C, Humbert J. Genetic diversity of Cylindrospermopsis strains (cyanobacteria) isolated from four continents. Appl Environ Microbiol. 2005;71:1097-100 pubmed..On the other hand, they also suggested a recent colonization of Australia by African strains...
- Kopecny D, Briozzo P, Popelkova H, Sebela M, Koncitíková R, Spíchal L, et al. Phenyl- and benzylurea cytokinins as competitive inhibitors of cytokinin oxidase/dehydrogenase: a structural study. Biochimie. 2010;92:1052-62 pubmed publisher..By contrast to CPPU itself, APPU and several benzylureas bind only negligibly to the receptors and exhibit weak cytokinin activity. ..
- Mosoni P, Martin C, Forano E, Morgavi D. Long-term defaunation increases the abundance of cellulolytic ruminococci and methanogens but does not affect the bacterial and methanogen diversity in the rumen of sheep. J Anim Sci. 2011;89:783-91 pubmed publisher..This study also reports for the first time in sheep a selective effect of defaunation on the abundance of cellulolytic bacterial species. ..
- Molle V, Gulten G, Vilcheze C, Veyron Churlet R, Zanella Cleon I, Sacchettini J, et al. Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Mol Microbiol. 2010;78:1591-605 pubmed publisher..This study suggests that phosphorylation of InhA may represent an unusual mechanism that allows M. tuberculosis to regulate its mycolic acid content, thus offering a new approach to future anti-tuberculosis drug development. ..
- Rouhier N, Vlamis Gardikas A, Lillig C, Berndt C, Schwenn J, Holmgren A, et al. Characterization of the redox properties of poplar glutaredoxin. Antioxid Redox Signal. 2003;5:15-22 pubmed..However, the poplar glutaredoxin may be involved in the response to oxidative stress as its overexpression in Escherichia coli resulted in a higher resistance toward hydrogen peroxide, menadione, and tert-butyl hydroperoxide. ..
- Uroz S, Chhabra S, Camara M, Williams P, Oger P, Dessaux Y. N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities. Microbiology. 2005;151:3313-22 pubmed..R. erythropolis is therefore capable of modifying and degrading AHL signal molecules through both oxidoreductase and amidolytic activities. ..
- Radom J, Colin D, Thiebault F, Dognin Bergeret M, Mairet Coello G, Esnard Feve A, et al. Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain. Biochim Biophys Acta. 2006;1759:225-33 pubmed..Matrix-assisted laser desorption/ionization time of flight mass spectrometry analysis of the immunoprecipitate tryptic fragments allowed the identification of rQSOX-L protein. ..
- Rousseau Gueutin M, Gaston A, Ainouche A, Ainouche M, Olbricht K, Staudt G, et al. Tracking the evolutionary history of polyploidy in Fragaria L. (strawberry): new insights from phylogenetic analyses of low-copy nuclear genes. Mol Phylogenet Evol. 2009;51:515-30 pubmed publisher..Additionally, sequence analyses also revealed relaxed constraints on homoeologous copies at high ploidy level, as demonstrated by deletion events within DHAR coding sequences of some allo-octoploid haplotypes. ..
- Chan P, Risler J, Raguenez G, Salier J. The three heavy-chain precursors for the inter-alpha-inhibitor family in mouse: new members of the multicopper oxidase protein group with differential transcription in liver and brain. Biochem J. 1995;306 ( Pt 2):505-12 pubmed
- Jourand P, Giraud E, Bena G, Sy A, Willems A, Gillis M, et al. Methylobacterium nodulans sp. nov., for a group of aerobic, facultatively methylotrophic, legume root-nodule-forming and nitrogen-fixing bacteria. Int J Syst Evol Microbiol. 2004;54:2269-73 pubmed..The name Methylobacterium nodulans sp. nov. (type strain, ORS 2060(T)=CNCM I 2342(T)=LMG 21967(T)) is proposed for this group of root-nodule-forming bacteria...
- Ezraty B, Bos J, Barras F, Aussel L. Methionine sulfoxide reduction and assimilation in Escherichia coli: new role for the biotin sulfoxide reductase BisC. J Bacteriol. 2005;187:231-7 pubmed..Moreover, this work provides the first example of an enzyme that reduces free MetSO while having no activity on peptide-bound MetSO residues. ..
- Pagarete A, Allen M, Wilson W, Kimmance S, de Vargas C. Host-virus shift of the sphingolipid pathway along an Emiliania huxleyi bloom: survival of the fattest. Environ Microbiol. 2009;11:2840-8 pubmed publisher..This study provides a unique insight into the transcriptional interplay of homologous metabolic pathways between virus and host during temporal progression of oceanic E. huxleyi blooms. ..
- Bardon C, Poly F, Piola F, Pancton M, Comte G, Meiffren G, et al. Mechanism of biological denitrification inhibition: procyanidins induce an allosteric transition of the membrane-bound nitrate reductase through membrane alteration. FEMS Microbiol Ecol. 2016;92:fiw034 pubmed publisher..brassicacearum responds by over-expressing membrane-bound NO3-reductase. Our results lead the way to a better understanding of BDI. ..
- Mougin C, Boyer F, Caminade E, Rama R. Cleavage of the diketonitrile derivative of the herbicide isoxaflutole by extracellular fungal oxidases. J Agric Food Chem. 2000;48:4529-34 pubmed..Purified laccase (EC 1. 10.3.2), in the presence of 2 mM 2, 2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) acting as a redox mediator at pH 3 supports the reaction with rates of 0.3-0.4 nmol h(-)(1) unit(-)(1). ..
- Simkin A, Labouré A, Kuntz M, Sandmann G. Comparison of carotenoid content, gene expression and enzyme levels in tomato (Lycopersicon esculentum) leaves. Z Naturforsch C. 2003;58:371-80 pubmed..In addition, monitoring of protein amounts for phytoene desaturase and plastid terminal oxidase (which sometimes do not correlate with gene expression) indicate an even more complex regulatory pattern. ..
- Philippot L. Denitrification in pathogenic bacteria: for better or worst?. Trends Microbiol. 2005;13:191-2 pubmed..Brucella spp. is an alpha-proteobacteriaceae that induces a persistent disease in some mammals. Recent work has revealed that a denitrifying gene cluster is important in the interaction of Brucella neotomoae with its host. ..
- Molina Heredia F, Houée Levin C, Berthomieu C, Touati D, Tremey E, Favaudon V, et al. Detoxification of superoxide without production of H2O2: antioxidant activity of superoxide reductase complexed with ferrocyanide. Proc Natl Acad Sci U S A. 2006;103:14750-5 pubmed..Altogether, these data describe an unprecedented O(2)(-.) detoxification activity, catalyzed by the SOR-ferrocyanide complex, which does not conduct to the production of the toxic H2O2 species...
- Bouteille N, Driouch K, Hage P, Sin S, Formstecher E, Camonis J, et al. Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene. 2009;28:2569-80 pubmed publisher..Our results indicate that WWOX is a novel inhibitor of the Wnt/beta-catenin pathway. WWOX would act, at least in part, by preventing the nuclear import of the Dvl proteins. ..
- Cournac L, Josse E, Joet T, Rumeau D, Redding K, Kuntz M, et al. Flexibility in photosynthetic electron transport: a newly identified chloroplast oxidase involved in chlororespiration. Philos Trans R Soc Lond B Biol Sci. 2000;355:1447-54 pubmed..This oxidase has immunological and pharmacological similarities with a plastid protein involved in carotenoid biosynthesis. ..
- Ducluzeau A, van Lis R, Duval S, Schoepp Cothenet B, Russell M, Nitschke W. Was nitric oxide the first deep electron sink?. Trends Biochem Sci. 2009;34:9-15 pubmed publisher..Aerobic respiration emerged later from within this ancestral pathway via adaptation of the enzyme NO reductase to its new substrate, dioxygen. ..
- Nzoué A, Miché L, Klonowska A, Laguerre G, de Lajudie P, Moulin L. Multilocus sequence analysis of bradyrhizobia isolated from Aeschynomene species in Senegal. Syst Appl Microbiol. 2009;32:400-12 pubmed publisher..The nine loci or nifH phylogenies were not correlated with the unusual symbiotic properties of PB (nod-dependent/nod-independent). Advantages and drawbacks of MLSA for species delineation in Bradyrhizobium are discussed. ..
- Luo Y, Nicaud J, Van Veldhoven P, Chardot T. The acyl-CoA oxidases from the yeast Yarrowia lipolytica: characterization of Aox2p. Arch Biochem Biophys. 2002;407:32-8 pubmed..Taken together, these data suggest that micelles of long-chain acyl-CoAs are able to bind and inhibit Aox2p. The enzyme was also active toward acyl-CoA-esters containing a 2-methyl group, but only the 2S isomer was recognized. ..
- Baraquet C, Theraulaz L, Iobbi Nivol C, Mejean V, Jourlin Castelli C. Unexpected chemoreceptors mediate energy taxis towards electron acceptors in Shewanella oneidensis. Mol Microbiol. 2009;73:278-90 pubmed publisher..Four other chemoreceptors also play a minor role in this process. These results indicate that energy taxis can be mediated by new types of chemoreceptors. ..
- Vignais P, Dimon B, Zorin N, Colbeau A, Elsen S. HupUV proteins of Rhodobacter capsulatus can bind H2: evidence from the H-D exchange reaction. J Bacteriol. 1997;179:290-2 pubmed..These data suggest that the HupSL dimer is periplasmically oriented, while the HupUV proteins are in the cytoplasmic compartment. ..
- Coudevylle N, Antoine M, Bouguet Bonnet S, Mutzenhardt P, Boschi Muller S, Branlant G, et al. Solution structure and backbone dynamics of the reduced form and an oxidized form of E. coli methionine sulfoxide reductase A (MsrA): structural insight of the MsrA catalytic cycle. J Mol Biol. 2007;366:193-206 pubmed
- Markov G, Tavares R, Dauphin Villemant C, Demeneix B, Baker M, Laudet V. Independent elaboration of steroid hormone signaling pathways in metazoans. Proc Natl Acad Sci U S A. 2009;106:11913-8 pubmed publisher..Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics. ..
- Lieutaud A, van Lis R, Duval S, Capowiez L, Muller D, Lebrun R, et al. Arsenite oxidase from Ralstonia sp. 22: characterization of the enzyme and its interaction with soluble cytochromes. J Biol Chem. 2010;285:20433-41 pubmed publisher..Kinetic studies furthermore established that sulfite and sulfide, substrates of the sox system, are both inhibitors of Aro activity. These results reinforce the idea that sulfur and arsenic metabolism are linked...
- Aubert Jousset E, Cano M, Guedeney G, Richaud P, Cournac L. Role of HoxE subunit in Synechocystis PCC6803 hydrogenase. FEBS J. 2011;278:4035-43 pubmed publisher..These data suggest different mechanisms for diaphorase-mediated electron donation and catalytic site activation in cyanobacterial hydrogenase. ..
- Sabaty M, Grosse S, Adryanczyk G, Boiry S, Biaso F, Arnoux P, et al. Detrimental effect of the 6 His C-terminal tag on YedY enzymatic activity and influence of the TAT signal sequence on YedY synthesis. BMC Biochem. 2013;14:28 pubmed publisher..It brings new insights into molybdoenzyme maturation in R. sphaeroides showing that for some enzymes, maturation can occur in the absence of the signal sequence but that its presence is required for high expression of active enzyme. ..
- Délye C, Ronchi V, Laigret F, Corio Costet M. Nested allele-specific PCR primers distinguish genetic groups of Uncinula necator. Appl Environ Microbiol. 1999;65:3950-4 pubmed
- Le Deunff E, Davoine C, Le Dantec C, Billard J, Huault C. Oxidative burst and expression of germin/oxo genes during wounding of ryegrass leaf blades: comparison with senescence of leaf sheaths. Plant J. 2004;38:421-31 pubmed..G-OXOs might be crucial during critical events in the life of plants such as cutting and senescence by initiating H(2)O(2)-mediated defences against pathogens and foraging animals. ..
- Pinon A, Limami Y, Micallef L, Cook Moreau J, Liagre B, Delage C, et al. A novel form of melanoma apoptosis resistance: melanogenesis up-regulation in apoptotic B16-F0 cells delays ursolic acid-triggered cell death. Exp Cell Res. 2011;317:1669-76 pubmed publisher..Our results confirm the difficulty of treating melanomas, since, even undergoing apoptosis, cells are nevertheless able to trigger a resistance mechanism to delay death. ..
- Fontaine L, Meynial Salles I, Girbal L, Yang X, Croux C, Soucaille P. Molecular characterization and transcriptional analysis of adhE2, the gene encoding the NADH-dependent aldehyde/alcohol dehydrogenase responsible for butanol production in alcohologenic cultures of Clostridium acetobutylicum ATCC 824. J Bacteriol. 2002;184:821-30 pubmed..acetobutylicum ATCC 824, and to our knowledge this is the first example of a bacterium with two AADHs. It is noteworthy that the two corresponding genes, adhE and adhE2, are carried by the pSOL1 megaplasmid of C. acetobutylicum ATCC 824...
- Reinbothe S, Pollmann S, Reinbothe C. In situ conversion of protochlorophyllide b to protochlorophyllide a in barley. Evidence for a novel role of 7-formyl reductase in the prolamellar body of etioplasts. J Biol Chem. 2003;278:800-6 pubmed..Our findings suggest that etiolated plants make use of 7-formyl reductase to fine tune the levels of Pchlide b and Pchlide a and thereby may regulate the steady-state level of light-harvesting POR-Pchlide complex. ..
- Morin C, Zini R, Simon N, Tillement J. Dehydroepiandrosterone and alpha-estradiol limit the functional alterations of rat brain mitochondria submitted to different experimental stresses. Neuroscience. 2002;115:415-24 pubmed..The mechanism involved was independent of the classical genomic effect of steroids, the antioxidant properties but implicated a direct action on the mitochondrial membranes. ..
- Kuntz L, Tritsch D, Grosdemange Billiard C, Hemmerlin A, Willem A, Bach T, et al. Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase. Biochem J. 2005;386:127-35 pubmed..The latter phosphonohydroxamic acid showed a high inhibitory activity towards DXR, much like fosmidomycin, as well as significant antibacterial activity against Escherichia coli in tests on Petri dishes. ..
- Renard Merlier D, Randoux B, Nowak E, Farcy F, Durand R, Reignault P. Iodus 40, salicylic acid, heptanoyl salicylic acid and trehalose exhibit different efficacies and defence targets during a wheat/powdery mildew interaction. Phytochemistry. 2007;68:1156-64 pubmed..The newly described protective efficacies and the partial, distinct and non-overlapping activities of these inducers on the wheat/powdery mildew interaction are discussed. ..
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