Genomes and Genes
Experts and Doctors on oxidative stress in United States
Locale: United States
Topic: oxidative stress
Publications438 found, 100 shown here
- Wang S, Chong Z, Shang Y, Maiese K. WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1. Curr Neurovasc Res. 2013;10:54-69 pubmed..Elucidation of the critical pathways of WISP1 that determine neuronal cell survival during oxidative stress may offer novel therapeutic avenues for neurodegenerative disorders. ..
- Sharma G, Kodali V, Gaffrey M, Wang W, Minard K, Karin N, et al. Iron oxide nanoparticle agglomeration influences dose rates and modulates oxidative stress-mediated dose-response profiles in vitro. Nanotoxicology. 2014;8:663-75 pubmed publisher..The combined experimental and computational approach provides a quantitative framework for evaluating relationships between the biocompatibility of nanoparticles and their physical and chemical characteristics. ..
- Farzan S, Chen Y, Trachtman H, Trasande L. Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003-2008. Environ Res. 2016;144:149-157 pubmed publisher..Prospective work is needed to investigate the potential long-term health consequences of these findings. ..
- Chen F, Wang C, Kim E, Harrison L. Hyperthermia in combination with oxidative stress induces autophagic cell death in HT-29 colon cancer cells. Cell Biol Int. 2008;32:715-23 pubmed publisher..Thermal sensitization through modulation of cellular ROS may represent a novel approach to increase the efficacy of hyperthermia as an anticancer modality. ..
- Chen X, Kintner D, Luo J, Baba A, Matsuda T, Sun D. Endoplasmic reticulum Ca2+ dysregulation and endoplasmic reticulum stress following in vitro neuronal ischemia: role of Na+-K+-Cl- cotransporter. J Neurochem. 2008;106:1563-76 pubmed publisher..Inhibition of NKCC1 reduced cytochrome C release and neuronal death. Taken together, these results suggest that NKCC1 and NCX(rev) may be involved in ischemic cell damage in part via disrupting ER Ca(2+) homeostasis and ER function. ..
- Paromov V, Qui M, Yang H, Smith M, Stone W. The influence of N-acetyl-L-cysteine on oxidative stress and nitric oxide synthesis in stimulated macrophages treated with a mustard gas analogue. BMC Cell Biol. 2008;9:33 pubmed publisher..Although NAC reduced oxidative stress in LPS stimulated macrophages treated with CEES, it did not reverse CEES-induced loss of NO production. NAC and polymyxin B were found to help prevent CEES toxicity in LPS-treated macrophages. ..
- Kim K, Lin Y, Park Y. Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster. Exp Gerontol. 2010;45:984-7 pubmed publisher..We also showed that development at a lower temperature represented by 18°C significantly downregulates anti-microbial peptide genes, AttA and DptB, of Imd pathway. ..
- Feng W, Madajka M, Kerr B, Mahabeleshwar G, Whiteheart S, Byzova T. A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing. Blood. 2011;117:3893-902 pubmed publisher..Our data demonstrate that platelets stimulate BMDC homing in a VAMP-8-dependent manner, revealing a previously unknown role for platelets as key mediators between hypoxic tissues and the bone marrow during angiogenesis. ..
- Fleming J, Phiel C, Toland A. The role for oxidative stress in aberrant DNA methylation in Alzheimer's disease. Curr Alzheimer Res. 2012;9:1077-96 pubmed..We also highlight the evidence for the role of oxidative damage contributing to DNA hypomethylation in AD patients through several mechanisms as well as implications for disease understanding and therapeutic development. ..
- Seth R, Das S, Kumar A, Chanda A, Kadiiska M, Michelotti G, et al. CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. Toxicol Appl Pharmacol. 2014;274:42-54 pubmed publisher..It also provides a novel insight of immune dysregulation and may be a key biomarker in NASH. ..
- Tostes R, Carneiro F, Carvalho M, Reckelhoff J. Reactive oxygen species: players in the cardiovascular effects of testosterone. Am J Physiol Regul Integr Comp Physiol. 2016;310:R1-14 pubmed publisher..The controversial effects of testosterone on ROS generation and oxidant status, both prooxidant and antioxidant, in the cardiovascular system and in cells and tissues of other systems are reviewed. ..
- Coursin D, Wood K. Corticosteroid supplementation for adrenal insufficiency. JAMA. 2002;287:236-40 pubmed
- Zheng J, Mutcherson R, Helfand S. Calorie restriction delays lipid oxidative damage in Drosophila melanogaster. Aging Cell. 2005;4:209-16 pubmed..These studies associate damage from lipid peroxidation with aging and lifespan in Drosophila and show that calorie restriction in flies, as in mammals, slows the accumulation of lipid related oxidative damage. ..
- Mathews M, Berk B. PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. Arterioscler Thromb Vasc Biol. 2008;28:711-7 pubmed publisher..PARP-1 inhibition prevents ROS- and RNS-induced HUVEC death by maintaining cellular energy in the form of NAD(+) and ATP, and also by activating a survival pathway via VEGFR2, Akt, and BAD phosphorylation. ..
- Sripathy S, Chaplin L, Gaikwad N, Rogan E, Montano M. hPMC2 is required for recruiting an ERbeta coactivator complex to mediate transcriptional upregulation of NQO1 and protection against oxidative DNA damage by tamoxifen. Oncogene. 2008;27:6376-84 pubmed publisher..We conclude that ERbeta and hPMC2 are required for TOT-dependent recruitment of coactivators such as PARP-1 to the EpRE resulting in the induction of antioxidative enzymes and subsequent protection against ODD. ..
- Tyagi N, Moshal K, Sen U, Vacek T, Kumar M, Hughes W, et al. H2S protects against methionine-induced oxidative stress in brain endothelial cells. Antioxid Redox Signal. 2009;11:25-33 pubmed publisher..In conclusion, the administration of H2S protected the cells from oxidative stress induced by hyperhomocysteinemia (HHcy), which suggested that NaHS/H2S may have therapeutic potential against Met-induced oxidative stress. ..
- Ikotun O, Higbee E, Ouellette W, Doyle R. Pyrophosphate-bridged complexes with picomolar toxicity. J Inorg Biochem. 2009;103:1254-64 pubmed publisher..Overall a clear picture of the extraordinary toxicity emerged. The results demonstrate a new class of prodrugs with significant potential for future development for the treatment of drug-resistant cancer cell lines. ..
- Storz P. Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal. 2011;14:593-605 pubmed publisher..Thus, FOXO transcription factors are of vital importance in processes regulating tumor survival or progression, stem cell maintenance, age-related pathological processes, and lifespan extension. ..
- Choi H, Kang K, Fukui M, Zhu B. Critical role of the JNK-p53-GADD45? apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons. Br J Pharmacol. 2011;162:175-92 pubmed publisher..Pharmacological inhibition of this signalling cascade may provide an effective strategy for neuroprotection. ..
- Cavazos D, Price R, Apte S, deGraffenried L. Docosahexaenoic acid selectively induces human prostate cancer cell sensitivity to oxidative stress through modulation of NF-?B. Prostate. 2011;71:1420-8 pubmed publisher..We therefore propose that DHA selectively sensitizes prostate cancer cells to growth arrest through attenuation of the NF-?B survival pathway. ..
- Nishijima Y, Sridhar A, Bonilla I, Velayutham M, Khan M, Terentyeva R, et al. Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology. Cardiovasc Res. 2011;91:71-9 pubmed publisher..Modulation of NOS2 activity by repletion of BH(4) may be a safe and effective approach to reduce the frequency of atrial arrhythmias during heart failure...
- Garcia M, Amankwa Sakyi M, Flynn T. Cellular glutathione in fatty liver in vitro models. Toxicol In Vitro. 2011;25:1501-6 pubmed publisher..The results of this in vitro study suggest an antioxidant response against fat overloading and indicate potential differences in response to specific fatty acid-induced hepatic steatosis and associated lipotoxicity. ..
- Johnson M, Demarco V, Heesch C, Whaley Connell A, Schneider R, Rehmer N, et al. Sex differences in baroreflex sensitivity, heart rate variability, and end organ damage in the TGR(mRen2)27 rat. Am J Physiol Heart Circ Physiol. 2011;301:H1540-50 pubmed publisher..These data demonstrated relative protection in females from autonomic dysfunction and end-organ damage associated with elevated blood pressure in the Ren2 model of hypertension. ..
- Malinin N, West X, Byzova T. Oxidation as "the stress of life". Aging (Albany NY). 2011;3:906-10 pubmed..Importantly, besides their role in a number of pathologies, oxidative products of phospholipids contribute to tissue repair processes thereby antagonizing the destructive effects of oxidation. ..
- Sha S, Kanicki A, Halsey K, Wearne K, Schacht J. Antioxidant-enriched diet does not delay the progression of age-related hearing loss. Neurobiol Aging. 2012;33:1010.e15-6 pubmed publisher..We conclude that dietary manipulations can alter cochlear antioxidant capacity but do not ameliorate age-related sensorineural hearing loss in the CBA/J mouse. ..
- Howard A, McNeil A, McNeil P. Promotion of plasma membrane repair by vitamin E. Nat Commun. 2011;2:597 pubmed publisher..Our work suggests a novel biological function for vitamin E in promoting myocyte plasma membrane repair. We propose that this function is essential for maintenance of skeletal muscle homeostasis. ..
- Lopez Martinez G, Hahn D. Short-term anoxic conditioning hormesis boosts antioxidant defenses, lowers oxidative damage following irradiation and enhances male sexual performance in the Caribbean fruit fly, Anastrepha suspensa. J Exp Biol. 2012;215:2150-61 pubmed publisher..We suggest that hormetic treatments specifically designed to enhance antioxidant activity may produce more sexually competitive sterile males, thus improving the efficacy and economy of SIT programs. ..
- Wang J, Xu J, Wang Q, Brainard R, Watson L, Jones S, et al. Reduced cardiac fructose 2,6 bisphosphate increases hypertrophy and decreases glycolysis following aortic constriction. PLoS ONE. 2013;8:e53951 pubmed publisher..These results indicate that the heart's capacity to increase F-2,6-P(2) during pressure overload elevates glycolysis which is beneficial for reducing pressure overload induced cardiac hypertrophy, dysfunction and fibrosis. ..
- Manley S, Williams J, Ding W. Role of p62/SQSTM1 in liver physiology and pathogenesis. Exp Biol Med (Maywood). 2013;238:525-38 pubmed publisher..In this review, we discuss the pathophysiological role of p62 in the liver, including formation of hepatic inclusion bodies, cholestasis, obesity, insulin resistance, liver cell death and tumourigenesis. ..
- Gopalakrishnan A, Ji L, Cirelli C. Sleep deprivation and cellular responses to oxidative stress. Sleep. 2004;27:27-35 pubmed..The available data do not support the assumption that prolonged wakefulness may cause oxidative damage, nor that it can represent an oxidative stress for the brain or for peripheral tissue such as liver and skeletal muscle. ..
- Patlolla A, Barnes C, Hackett D, Tchounwou P. Potassium dichromate induced cytotoxicity, genotoxicity and oxidative stress in human liver carcinoma (HepG2) cells. Int J Environ Res Public Health. 2009;6:643-53 pubmed publisher..69 + 0.19%-% Tail DNA], respectively. The results demonstrated that potassium dichromate was highly cytotoxic to HepG2 cells, and its cytotoxicity seems to be mediated by oxidative stress and DNA damage...
- Ismahil M, Hamid T, Haberzettl P, Gu Y, Chandrasekar B, Srivastava S, et al. Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2011;301:H2050-60 pubmed publisher..Human exposure to acrolein may have analogous effects and raise consideration of an environmental, aldehyde-mediated basis for heart failure...
- Miseta A, Fu L, Kellermayer R, Buckley J, Bedwell D. The Golgi apparatus plays a significant role in the maintenance of Ca2+ homeostasis in the vps33Delta vacuolar biogenesis mutant of Saccharomyces cerevisiae. J Biol Chem. 1999;274:5939-47 pubmed..These results indicate that the Golgi apparatus plays a significant role in maintaining Ca2+ homeostasis when vacuolar biogenesis is compromised. ..
- Choi S, Baumler D, Kaspar C. Contribution of dps to acid stress tolerance and oxidative stress tolerance in Escherichia coli O157:H7. Appl Environ Microbiol. 2000;66:3911-6 pubmed..The results from this study establish that Dps contributes to acid tolerance in E. coli O157:H7 and confirm the importance of Dps in oxidative stress protection. ..
- Lesort M, Tucholski J, Zhang J, Johnson G. Impaired mitochondrial function results in increased tissue transglutaminase activity in situ. J Neurochem. 2000;75:1951-61 pubmed..This study demonstrates for the first time that impairment of mitochondrial function significantly increases TG activity in situ, a finding that may have important relevance to the etiology of HD. ..
- Katusic Z. Vascular endothelial dysfunction: does tetrahydrobiopterin play a role?. Am J Physiol Heart Circ Physiol. 2001;281:H981-6 pubmed..In this review, the potential role of tetrahydrobiopterin in the pathogenesis of vascular endothelial dysfunction and mechanisms underlying beneficial vascular effects of tetrahydrobiopterin will be discussed...
- Shukla A, Jung M, Stern M, Fukagawa N, Taatjes D, Sawyer D, et al. Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis. Am J Physiol Lung Cell Mol Physiol. 2003;285:L1018-25 pubmed..Studies collectively indicate that mitochondria are initial targets of asbestos-induced DNA damage and apoptosis via an oxidant-related mechanism. ..
- Agarwal A, Prabakaran S, Allamaneni S. What an andrologist/urologist should know about free radicals and why. Urology. 2006;67:2-8 pubmed
- Ghaziani T, Shan Y, Lambrecht R, Donohue S, Pietschmann T, Bartenschlager R, et al. HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells. J Hepatol. 2006;45:5-12 pubmed..These and other results suggest a key role of down-regulation of Bach1 and up-regulation of HO-1 in diminishing cytotoxic effects of HCV proteins in human hepatocytes. ..
- Zhang Q, Eaton L, Snyder E, Houghtaling S, Mitchell J, Finegold M, et al. Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Cancer Res. 2008;68:1601-8 pubmed publisher..The reduction in oxidative DNA damage in tempol-treated FA fibroblasts and mice suggests that its tumor-delaying function may be attributed to its antioxidant activity. ..
- Bridges J, Gilbert J, Colson D, Gilbert S, Dukes M, Ryan M, et al. Oxidative stress contributes to soluble fms-like tyrosine kinase-1 induced vascular dysfunction in pregnant rats. Am J Hypertens. 2009;22:564-8 pubmed publisher..05) by the superoxide scavenger Tiron. These data indicate elevated maternal sFlt-1 and decreased VEGF concentrations results in increased oxidative stress that contributes to vascular dysfunction during pregnancy. ..
- Pang Y, Campbell L, Zheng B, Fan L, Cai Z, Rhodes P. Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development. Neuroscience. 2010;166:464-75 pubmed publisher..Our finding that LPS-activated microglia not only induce two waves of cell death but also greatly impair OL development may shed some light on the mechanisms underlying selective white matter damage and hypomyelination in PVL. ..
- Reich K, Chen Y, Thompson P, Hoffman E, Clarkson P. Forty-eight hours of unloading and 24 h of reloading lead to changes in global gene expression patterns related to ubiquitination and oxidative stress in humans. J Appl Physiol (1985). 2010;109:1404-15 pubmed publisher..The gene expression patterns were not reversed on RL, suggesting that molecular responses to short-term periods of skeletal muscle inactivity may persist after activity resumes...
- Sahu S, O Donnell M, Wiesenfeld P. Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture. J Appl Toxicol. 2010;30:566-73 pubmed publisher..The liver cells used in this study showed distinct endpoint-sensitivity to DON related to the species. ..
- Reeder B, Svistunenko D, Wilson M. Lipid binding to cytoglobin leads to a change in haem co-ordination: a role for cytoglobin in lipid signalling of oxidative stress. Biochem J. 2011;434:483-92 pubmed publisher..We propose that the binding of ferric cytoglobin to lipids and their subsequent transformation may be integral to the physiological function of cytoglobin, generating cell signalling lipid molecules under an oxidative environment. ..
- George E, Hosick P, Stec D, Granger J. Heme oxygenase inhibition increases blood pressure in pregnant rats. Am J Hypertens. 2013;26:924-30 pubmed publisher..3005±301 RLU/min/mg; P < 0.05). Our results demonstrate that HO is an important regulator of blood pressure and an important antioxidant in the developing placenta. ..
- Hori T, Gardner L, Hata T, Chen F, Baine A, Uemoto S, et al. Pretreatment of liver grafts in vivo by ?-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat. Ann Transplant. 2013;18:299-313 pubmed publisher..A specific agonist demonstrated regulation of GABAR in vivo in the liver. This activation in vivo reduced OS after OLT via the ATM/H2AX pathway. ..
- Du Y, Veenstra A, Palczewski K, Kern T. Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A. 2013;110:16586-91 pubmed publisher..Photoreceptors are the major source of superoxide generated by retinas of diabetic mice. Pharmaceuticals targeting photoreceptor oxidative stress could offer a unique therapy for diabetic retinopathy. ..
- Kim Y, Byzova T. Oxidative stress in angiogenesis and vascular disease. Blood. 2014;123:625-31 pubmed publisher..This review aims to provide a summary of the past and present views on the role of oxidative stress as a mediator and modulator of angiogenesis, and to highlight newly identified mechanisms. ..
- Velayudhan J, Karlinsey J, Frawley E, Becker L, Nartea M, Fang F. Distinct roles of the Salmonella enterica serovar Typhimurium CyaY and YggX proteins in the biosynthesis and repair of iron-sulfur clusters. Infect Immun. 2014;82:1390-401 pubmed publisher..Salmonella experiences oxidative and nitrosative stress within host phagocytes, and CyaY-dependent maintenance of labile iron-sulfur clusters appears to be important for Salmonella virulence. ..
- Klein R, Myers C, Cruickshanks K, Gangnon R, Danforth L, Sivakumaran T, et al. Markers of inflammation, oxidative stress, and endothelial dysfunction and the 20-year cumulative incidence of early age-related macular degeneration: the Beaver Dam Eye Study. JAMA Ophthalmol. 2014;132:446-55 pubmed publisher..Even if inflammatory processes are a cause of early AMD, it is not known whether interventions that reduce systemic inflammatory processes will reduce the incidence of early AMD. ..
- Joshi A, Iyengar R, Joo J, Li Harms X, Wright C, Marino R, et al. Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1. Cell Death Differ. 2016;23:216-30 pubmed publisher..On the basis of our data, we propose that the subcellular distribution of ULK1 has an important role in deciding whether a cell lives or dies on exposure to adverse environmental or intracellular conditions. ..
- Dallalio G, Means R. Effects of oxidative stress on human erythroid colony formation: Modulation by gamma-interferon. J Lab Clin Med. 2003;141:395-400 pubmed..These findings suggest that inflammatory cytokines implicated in the pathogenesis of the anemia of chronic disease may exert their effects at least in part through modulation of oxidative stress. ..
- Khramtsov V, Grigor ev I, Foster M, Lurie D. In vitro and in vivo measurement of pH and thiols by EPR-based techniques. Antioxid Redox Signal. 2004;6:667-76 pubmed..The applications of some newly developed pH and SH probes in model systems of pharmacological interest, biological fluids, tissues, and cells as well as in vivo studies in isolated hearts and in the gut of living animals are discussed. ..
- Turchan Cholewo J, Liu Y, Gartner S, Reid R, Jie C, Peng X, et al. Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl. Neurobiol Dis. 2006;23:109-19 pubmed..In conclusion, opiate abusers with HIV infection and the ApoE4 allele may be at increased risk of developing dementia. L-deprenyl and a plant estrogen, diosgenin, may have therapeutic potential in this population. ..
- Yanes L, Romero D, Iles J, Iliescu R, Gomez Sanchez C, Reckelhoff J. Sexual dimorphism in the renin-angiotensin system in aging spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2006;291:R383-90 pubmed
- Ahn J, Ambrosone C, Kanetsky P, Tian C, Lehman T, Kropp S, et al. Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer. Clin Cancer Res. 2006;12:7063-70 pubmed..Regression trees may be useful in future studies to examine the contributions of multiple factors to individual susceptibility to adverse effects of cancer treatment. ..
- Robalino J, Almeida J, McKillen D, Colglazier J, Trent H, Chen Y, et al. Insights into the immune transcriptome of the shrimp Litopenaeus vannamei: tissue-specific expression profiles and transcriptomic responses to immune challenge. Physiol Genomics. 2007;29:44-56 pubmed
- Liu Y, Kern J, Walker J, Johnson J, Schultz P, Luesch H. A genomic screen for activators of the antioxidant response element. Proc Natl Acad Sci U S A. 2007;104:5205-10 pubmed..This work and other such studies may provide mechanisms for activating the ARE in the absence of general oxidative stress and a yet-unexploited therapeutic approach to degenerative diseases and aging. ..
- Sola A, Rogido M, Deulofeut R. Oxygen as a neonatal health hazard: call for détente in clinical practice. Acta Paediatr. 2007;96:801-12 pubmed..Neonatal exposure to pure O2, even if brief, or to pulse oximetry >95% when breathing supplemental O2 must be avoided as much as possible. ..
- Hoegger M, Lieven C, Levin L. Differential production of superoxide by neuronal mitochondria. BMC Neurosci. 2008;9:4 pubmed publisher..Diversity in METC component expression and function could explain tissue specificity in diseases associated with inherited mtDNA abnormalities. ..
- Novgorodov S, Gudz T, Obeid L. Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore. J Biol Chem. 2008;283:24707-17 pubmed publisher..These results suggest a novel mechanism of ceramide regulation of mitochondrial function. ..
- Gasiorowski J, Russell P. Biological properties of trabecular meshwork cells. Exp Eye Res. 2009;88:671-5 pubmed publisher..Hopefully the study of cultured trabecular meshwork cells will provide a better understanding of glaucoma and lead to new, much needed therapies. ..
- Ferreira L, Gilliam L, Reid M. L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro. J Appl Physiol (1985). 2009;107:211-6 pubmed publisher..C = 65 +/- 8%, P < 0.05] as did the 2-h OTC treatment (OTC = 38 +/- 9% vs. C = 51 +/- 9%, P < 0.05). These results demonstrate that OTC modulates the muscle GSH pool and opposes fatigue under the current experimental conditions. ..
- Li J, Ichikawa T, Janicki J, Cui T. Targeting the Nrf2 pathway against cardiovascular disease. Expert Opin Ther Targets. 2009;13:785-94 pubmed publisher..Herein, we review the current literature that suggests that Nrf2 is a valuable therapeutic target for cardiovascular disease, as well as experiments that illustrate the mechanisms of Nrf2 cardioprotection. ..
- Whaley Connell A, Nistala R, Habibi J, Hayden M, Schneider R, Johnson M, et al. Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat. Am J Physiol Renal Physiol. 2010;298:F655-61 pubmed publisher..Our results highlight both the importance of pressor-related reductions on podocyte integrity and albuminuria as well as RAS-mediated oxidant stress largely comparable between ARB and renin inhibition treatment. ..
- Deveau A, Piispanen A, Jackson A, Hogan D. Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. Eukaryot Cell. 2010;9:569-77 pubmed publisher..Our results suggest that farnesol effects on the Ras-adenylate cyclase cascade are responsible for many of the observed activities of this fungal signaling molecule...
- Yang L, Latchoumycandane C, McMullen M, Pratt B, Zhang R, Papouchado B, et al. Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. J Biol Chem. 2010;285:22211-20 pubmed publisher..Suppressing hepatic inflammation, not ethanol catabolism, reduces circulating inflammatory and apoptotic agonists. ..
- Niu S, Li F, Tan D, Zhang L, Idle J, Gonzalez F, et al. Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in mice. J Pineal Res. 2010;49:106-14 pubmed publisher..These data suggest that AFMK/AMK formation is not a significant pathway of melatonin disposition in mice, even under conditions of oxidative stress. ..
- Ngoh G, Watson L, Facundo H, Jones S. Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes. Amino Acids. 2011;40:895-911 pubmed publisher..We conclude that inhibition of Ca(2+) overload and ROS generation (inducers of mPTP) might be one mechanism through which O-GlcNAcylation reduces ischemia/hypoxia-mediated mPTP formation. ..
- Tew K, Townsend D. Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification. Drug Metab Rev. 2011;43:179-93 pubmed publisher..As such, there is an ongoing preclinical and clinical platform of drug discovery and development around GSTP. ..
- Findeisen H, Pearson K, Gizard F, Zhao Y, Qing H, Jones K, et al. Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis. PLoS ONE. 2011;6:e18532 pubmed publisher..Collectively, these data demonstrate a previously unrecognized role of oxidative stress in the regulation of adipogenesis which may contribute to age-associated adipose tissue dysfunction. ..
- Hamada A, Sharma R, du Plessis S, Willard B, Yadav S, Sabanegh E, et al. Two-dimensional differential in-gel electrophoresis-based proteomics of male gametes in relation to oxidative stress. Fertil Steril. 2013;99:1216-1226.e2 pubmed publisher..To identify the relative abundance of proteins in pooled reactive oxygen species (ROS)-positive (ROS+) and ROS-negative (ROS-) semen samples with the use of two-dimensional differential in-gel electrophoresis (2D-DIGE)...
- Phillips M, Byrnes R, Cataneo R, Chaturvedi A, Kaplan P, Libardoni M, et al. Detection of volatile biomarkers of therapeutic radiation in breath. J Breath Res. 2013;7:036002 pubmed publisher..8 Gy and higher. VOC breath testing could provide a new tool for rapid and non-invasive radiation biodosimetry. ..
- Veeranki S, Givvimani S, Kundu S, Metreveli N, Pushpakumar S, Tyagi S. Moderate intensity exercise prevents diabetic cardiomyopathy associated contractile dysfunction through restoration of mitochondrial function and connexin 43 levels in db/db mice. J Mol Cell Cardiol. 2016;92:163-173 pubmed publisher
- Otis J, Brown L, Guidot D. Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats. Muscle Nerve. 2007;36:842-8 pubmed..Therefore, targeted anti-oxidant treatments such as procysteine supplementation may benefit individuals with chronic alcohol abuse, particularly if given prior to the development of clinically significant myopathy. ..
- Hu Z, Chen J, Wei Q, Xia Y. Bidirectional actions of hydrogen peroxide on endothelial nitric-oxide synthase phosphorylation and function: co-commitment and interplay of Akt and AMPK. J Biol Chem. 2008;283:25256-63 pubmed publisher..Long term H(2)O(2) exposure decreased eNOS Ser(1179) phosphorylation, and this might account for the loss of eNOS function in cardiovascular diseases where chronic oxidative injury occurs. ..
- Rempel M, Hester B, Deharo H, Hong H, Wang Y, Schlenk D. Effects of 17beta-estradiol, and its metabolite, 4-hydroxyestradiol on fertilization, embryo development and oxidative DNA damage in sand dollar (Dendraster excentricus) sperm. Sci Total Environ. 2009;407:2209-15 pubmed publisher..The results indicate that biotransformation of E2 to 4OHE2 enhances oxidative damage of DNA in sperm, which can reduce fertilization and impair embryonic development, but other mechanisms of action may also contribute to these effects. ..
- Saxena G, Chen J, Shalev A. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem. 2010;285:3997-4005 pubmed publisher..Thus, we discovered that TXNIP shuttles between subcellular compartments in response to oxidative stress and identified a novel redox-sensitive mitochondrial TXNIP-Trx2-ASK1 signaling cascade. ..
- Cornelli U. Treatment of Alzheimer's disease with a cholinesterase inhibitor combined with antioxidants. Neurodegener Dis. 2010;7:193-202 pubmed publisher..The MMSE II score remained almost the same in the group treated with donepezil and placebo, whereas some significant improvements were found in the group treated with donepezil plus formula F. ..