Experts and Doctors on oxidative stress in Norway


Locale: Norway
Topic: oxidative stress

Top Publications

  1. Jonson I, Ougland R, Klungland A, Larsen E. Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells. Stem Cell Res. 2013;11:1264-71 pubmed publisher
    ..We also found that differentiation status, and consequently DNA repair efficiency influenced somatic expansion. Our data underscore the importance of DNA damage and repair for the stability of the HD triplet in pluripotent stem cells. ..
  2. Agledal L, Niere M, Ziegler M. The phosphate makes a difference: cellular functions of NADP. Redox Rep. 2010;15:2-10 pubmed publisher
    ..The increasing recognition of the multiple roles of NADP has thus led to exciting new insights in this expanding field. ..
  3. Espe M, Holen E. Taurine attenuates apoptosis in primary liver cells isolated from Atlantic salmon (Salmo salar). Br J Nutr. 2013;110:20-8 pubmed publisher
    ..In conclusion, taurine attenuated apoptosis in primary liver cells isolated from Atlantic salmon, and as such, taurine may be conditionally indispensable in Atlantic salmon. ..
  4. Rode T, Møretrø T, Langsrud S, Langsrud O, Vogt G, Holck A. Responses of Staphylococcus aureus exposed to HCl and organic acid stress. Can J Microbiol. 2010;56:777-92 pubmed publisher
    ..Cells exposed to lactic acid showed specific mechanisms of action in addition to sharing many of the mechanisms induced by HCl stress. ..
  5. Escobar J, Sánchez Illana Ã, Kuligowski J, Torres Cuevas I, Solberg R, Garberg H, et al. Development of a reliable method based on ultra-performance liquid chromatography coupled to tandem mass spectrometry to measure thiol-associated oxidative stress in whole blood samples. J Pharm Biomed Anal. 2016;123:104-12 pubmed publisher
    ..23 nmol L(-1) for cysteine. The suitability of the method was ascertained in whole blood samples (n=80) from a consolidated experimental model of hypoxia-reoxygenation in newborn piglets. ..
  6. Kaur P, Aschner M, Syversen T. Role of glutathione in determining the differential sensitivity between the cortical and cerebellar regions towards mercury-induced oxidative stress. Toxicology. 2007;230:164-77 pubmed
    ..Hence, different approaches for the future studies regarding the mechanisms behind selectivity of MeHg have been discussed. ..
  7. Sandrini Neto L, Pereira L, Martins C, Silva de Assis H, Camus L, Lana P. Antioxidant responses in estuarine invertebrates exposed to repeated oil spills: Effects of frequency and dosage in a field manipulative experiment. Aquat Toxicol. 2016;177:237-49 pubmed publisher
    ..The bivalve A. brasiliana and the polychaete L. culveri are more suitable sentinels due to their greater responsiveness to oil and also to their wider geographical distribution. ..
  8. Ovrevik J, Refsnes M, Schwarze P, Låg M. The ability of oxidative stress to mimic quartz-induced chemokine responses is lung cell line-dependent. Toxicol Lett. 2008;181:75-80 pubmed publisher
    ..Moreover, the results from the BEAS-2B cells strengthen the notion that non-oxidant initiation mechanisms may also be important to the effects of mineral particles and fibers. ..
  9. Lauritzen K, Cheng C, Wiksen H, Bergersen L, Klungland A. Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses. DNA Repair (Amst). 2011;10:639-53 pubmed publisher
    ..Collectively, these changes lead to mitochondria with reduced function and increased oxidative stress. ..

More Information


  1. Berntssen M, Aatland A, Handy R. Chronic dietary mercury exposure causes oxidative stress, brain lesions, and altered behaviour in Atlantic salmon (Salmo salar) parr. Aquat Toxicol. 2003;65:55-72 pubmed
    ..However, above a threshold of 10 mg kg(-1) methylmercury these defences are overcome and lipid peroxidative injury (TBARS) as well as severe pathological damage and adverse behaviour become apparent. ..
  2. Kjaer M, Todorcević M, Torstensen B, Vegusdal A, Ruyter B. Dietary n-3 HUFA affects mitochondrial fatty acid beta-oxidation capacity and susceptibility to oxidative stress in Atlantic salmon. Lipids. 2008;43:813-27 pubmed publisher
    ..1 in the highest n-3 group compared to 6.6 in the intermediate group. These data clearly show an increased incidence of oxidative stress in the liver of fish fed the high n-3 diets. ..
  3. Saugstad O. Update on oxygen radical disease in neonatology. Curr Opin Obstet Gynecol. 2001;13:147-53 pubmed
    ..In the last year there have been no new breakthroughs in antioxidant therapy. ..
  4. Frantzen M, Regoli F, Ambrose W, Nahrgang J, Geraudie P, Benedetti M, et al. Biological effects of mechanically and chemically dispersed oil on the Icelandic scallop (Chlamys islandica). Ecotoxicol Environ Saf. 2016;127:95-107 pubmed publisher
    ..There was a concentration dependent increase in cumulative post-exposure mortality, but long-term effects on gonadosomatic index, somatic growth/condition factor did not differ among treatments. ..
  5. Helander L, Sharma A, Krokan H, Plaetzer K, Krammer B, Tortik N, et al. Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins. Mol Biosyst. 2016;12:796-805 pubmed publisher
    ..Several of the proteins constitute potentially novel redox-regulated apoptotic triggers as well as potential targets for adjuvants that may improve the efficacy of HAL-PDT and PDT using other photosensitizers. ..
  6. Alehagen U, Aaseth J, Johansson P. Less increase of copeptin and MR-proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Biofactors. 2015;41:443-52 pubmed publisher
    ..A cardioprotective effect of the supplementation was registered, irrespective of the initial levels of these biomarkers, and this protection was recognized also after 10 years of observation. ..
  7. Ravuri C, Svineng G, Pankiv S, Huseby N. Endogenous production of reactive oxygen species by the NADPH oxidase complexes is a determinant of ?-glutamyltransferase expression. Free Radic Res. 2011;45:600-10 pubmed publisher
    ..The GGT mRNA sub-type A was increased after PMA-induced NOX activation. These results demonstrate that ROS generated from NOX enzymes are a significant determinant for GGT expression and activity. ..
  8. Dalen M, Alme T, Bjørås M, Munkeby B, Rootwelt T, Saugstad O. Reduced expression of DNA glycosylases in post-hypoxic newborn pigs undergoing therapeutic hypothermia. Brain Res. 2010;1363:198-205 pubmed publisher
    ..We confirm increased oxidative stress after hypoxia. DNA repair glycosylases were down-regulated by hypothermia but with no effect on accumulation of oxidative damage in genomic DNA. ..
  9. Longhin E, Gualtieri M, Capasso L, Bengalli R, Mollerup S, Holme J, et al. Physico-chemical properties and biological effects of diesel and biomass particles. Environ Pollut. 2016;215:366-375 pubmed publisher
    ..This evidence emphasizes that the study of different emission sources contribution to ambient PM toxicity may have a fundamental role in the development of more effective strategies for air quality improvement. ..
  10. Collins A, Harrington V, Drew J, Melvin R. Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis. 2003;24:511-5 pubmed
    ..Kiwifruit provides a dual protection against oxidative DNA damage, enhancing antioxidant levels and stimulating DNA repair. It is probable that together these effects would decrease the risk of mutagenic changes leading to cancer. ..
  11. Dusinska M, Staruchova M, Horska A, Smolkova B, Collins A, Bonassi S, et al. Are glutathione S transferases involved in DNA damage signalling? Interactions with DNA damage and repair revealed from molecular epidemiology studies. Mutat Res. 2012;736:130-7 pubmed publisher
    ..Our results show that GST polymorphisms and GST activity can apparently influence DNA stability and repair of oxidised bases, suggesting a potential new role for these proteins in DNA damage processing via DNA damage signalling. ..
  12. Sanden M, Jørgensen S, Hemre G, Ørnsrud R, Sissener N. Zebrafish (Danio rerio) as a model for investigating dietary toxic effects of deoxynivalenol contamination in aquaculture feeds. Food Chem Toxicol. 2012;50:4441-8 pubmed publisher
    ..We do not know if effects observed on fecundity and larvae swimming activity are attributed to a direct interaction of DON with the reproductive organ or secondary to the maternal/paternal liver oxidative imbalance. ..
  13. Ibor O, Adeogun A, Chukwuka A, Arukwe A. Gross pathology, physiological and toxicological responses in relation to metals and persistent organic pollutants (POPs) burden in tilapia species from Ogun River, Nigeria. Mar Environ Res. 2017;129:245-257 pubmed publisher
  14. Udumula M, Babu M, Bhat A, Dhar I, Sriram D, Dhar A. High glucose impairs insulin signaling via activation of PKR pathway in L6 muscle cells. Biochem Biophys Res Commun. 2017;486:645-651 pubmed publisher
    ..Prevention of PKR activation, by safer and specific inhibitors is a therapeutic option in metabolic disorders that needs to be explored further. ..
  15. Mikkelsen I, Mortensen B, Laperche Y, Huseby N. The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress. Mol Cell Biochem. 2002;232:87-95 pubmed
    ..We conclude that GGT activity can be upregulated by at least two distinct mechanisms during differentiation and oxidative stress. Apparently, the regulation of the enzyme is not directly linked to the intracellular level of glutathione. ..
  16. Akbari M, Otterlei M, Pena Diaz J, Krokan H. Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience. 2007;145:1201-12 pubmed
    ..Furthermore, the upregulation of mRNA for mitochondrial UNG1 after oxidative stress indicates that it may have an important role in repair of oxidized pyrimidines. ..
  17. Yang M, Lin X, Rowe A, Rognes T, Eide L, Bjørås M. Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway. Sci Rep. 2015;5:17409 pubmed publisher
    ..In summary, OXR1 may act as a sensor of cellular oxidative stress to regulate the transcriptional networks required to detoxify reactive oxygen species and modulate cell cycle and apoptosis. ..
  18. Farmen E, Harman C, Hylland K, Tollefsen K. Produced water extracts from North Sea oil production platforms result in cellular oxidative stress in a rainbow trout in vitro bioassay. Mar Pollut Bull. 2010;60:1092-8 pubmed publisher
    ..Bioassay effects were only observed at high PW concentrations (3-fold concentrated), indicating that bioaccumulation needs to occur to cause similar short term toxic effects in wild fish. ..
  19. Hudecova A, Kusznierewicz B, Rundén Pran E, Magdolenova Z, Hasplova K, Rinna A, et al. Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea. Mutagenesis. 2012;27:759-69 pubmed publisher
    ..Oxidised DNA base lesions and strand breaks caused by AgNPs were diminished by aqueous and methanolic extracts from both haulm and flower of Gentiana asclepiadea...
  20. Vigerust N, Cacabelos D, Burri L, Berge K, Wergedahl H, Christensen B, et al. Fish oil and 3-thia fatty acid have additive effects on lipid metabolism but antagonistic effects on oxidative damage when fed to rats for 50 weeks. J Nutr Biochem. 2012;23:1384-93 pubmed publisher
    ..The experiment confirms the antioxidant capacity of TTA, showing an improvement in FO-induced oxidative stress...
  21. Duale N, Olsen A, Christensen T, Butt S, Brunborg G. Octyl methoxycinnamate modulates gene expression and prevents cyclobutane pyrimidine dimer formation but not oxidative DNA damage in UV-exposed human cell lines. Toxicol Sci. 2010;114:272-84 pubmed publisher
    ..The experimental approach applied in this study, using a panel of 17 genes in an in vitro cellular system together with genotoxicity assays, may be useful in the initial screening of active ingredients in sunscreens. ..
  22. Skugor S, Jørgensen S, Gjerde B, Krasnov A. Hepatic gene expression profiling reveals protective responses in Atlantic salmon vaccinated against furunculosis. BMC Genomics. 2009;10:503 pubmed publisher
    ..Factors that determine high individual variation of vaccination efficiency remain unknown. We used gene expression analyses to search for the correlates of vaccine protection against furunculosis in Atlantic salmon...
  23. Osenbroch P, Auk Emblem P, Halsne R, Strand J, Forstrøm R, van der Pluijm I, et al. Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells. FEBS J. 2009;276:2811-21 pubmed publisher
    ..Thus, mitochondrial dysfunction may play a role in the pathology of CS. ..
  24. Khalid A, Hafstad A, Larsen T, Severson D, Boardman N, Hagve M, et al. Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 2011;300:H2116-22 pubmed publisher
    ..The present study strongly advocates the need for investigation of the cardiac effects of PPAR ligands used in antidiabetic/hypolipidemic therapy, because of their pleiotropic properties. ..
  25. Pollak N, Niere M, Ziegler M. NAD kinase levels control the NADPH concentration in human cells. J Biol Chem. 2007;282:33562-71 pubmed
    ..Because the basal oxygen radical level in the cell lines was only slightly changed, the redox state of NADP may be a major transmitter of oxidative stress. ..
  26. Lillenes M, Støen M, Gómez Muñoz M, Torp R, Günther C, Nilsson L, et al. Transient OGG1, APE1, PARP1 and Pol? expression in an Alzheimer's disease mouse model. Mech Ageing Dev. 2013;134:467-77 pubmed publisher
    ..Transcriptional profiling also showed that BER repair capacity vary during the lifespan in Tg-ArcSwe and wt mice. The BER expression pattern in Tg-ArcSwe mice thus reflects responses to oxidative stress in vulnerable brain structures. ..
  27. Ampomah O, Jensen J, Bhuvaneswari T. Lack of trehalose catabolism in Sinorhizobium species increases their nodulation competitiveness on certain host genotypes. New Phytol. 2008;179:495-504 pubmed publisher
  28. Grindheim A, Hollås H, Raddum A, Saraste J, Vedeler A. Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2. J Cell Sci. 2016;129:314-28 pubmed publisher
    ..These results suggest that Tyr23 phosphorylation can regulate the function of AnxA2 at distinct subcellular sites. ..
  29. Pandur S, Pankiv S, Johannessen M, Moens U, Huseby N. Gamma-glutamyltransferase is upregulated after oxidative stress through the Ras signal transduction pathway in rat colon carcinoma cells. Free Radic Res. 2007;41:1376-84 pubmed
    ..Addition of specific inhibitors of these kinases during oxidative stress diminished the activation of GGT. In conclusion, oxidative stress-induced activation of GGT involves Ras and several downstream signalling pathways. ..
  30. Seehuus S, Norberg K, Gimsa U, Krekling T, Amdam G. Reproductive protein protects functionally sterile honey bee workers from oxidative stress. Proc Natl Acad Sci U S A. 2006;103:962-7 pubmed
    ..This perspective is of considerable relevance to research on longevity regulation that builds largely on inference from solitary model species. ..
  31. Yadetie F, Karlsen O, Lanzen A, Berg K, Olsvik P, Hogstrand C, et al. Global transcriptome analysis of Atlantic cod (Gadus morhua) liver after in vivo methylmercury exposure suggests effects on energy metabolism pathways. Aquat Toxicol. 2013;126:314-25 pubmed publisher
    ..These results based on changes on transcript levels, however, need to be confirmed by other methods such as proteomics...
  32. Meland S, Farmen E, Heier L, Rosseland B, Salbu B, Song Y, et al. Hepatic gene expression profile in brown trout (Salmo trutta) exposed to traffic related contaminants. Sci Total Environ. 2011;409:1430-43 pubmed publisher
    ..The observed responses were likely caused by an interaction of several contaminants including trace metals and organic micro-pollutants such as PAHs...
  33. Brevik A, Gaivão I, Medin T, Jørgenesen A, Piasek A, Elilasson J, et al. Supplementation of a western diet with golden kiwifruits (Actinidia chinensis var.'Hort 16A':) effects on biomarkers of oxidation damage and antioxidant protection. Nutr J. 2011;10:54 pubmed publisher
  34. Alseth I, Eide L, Pirovano M, Rognes T, Seeberg E, Bjørås M. The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast. Mol Cell Biol. 1999;19:3779-87 pubmed
    ..Ntg2 appears to be a nuclear enzyme, whereas Ntg1 was sorted both to the nucleus and to the mitochondria. We conclude that functions of both NTG1 and NTG2 are important for removal of oxidative DNA damage in yeast. ..
  35. Bøhn S, Myhrstad M, Thoresen M, Holden M, Karlsen A, Tunheim S, et al. Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers. BMC Med. 2010;8:54 pubmed publisher
    ..The observed changes in the blood cell gene expression profiles suggest that the beneficial effects of a plant-based diet on human health may be mediated through optimization of defence processes. ..
  36. Song Y, Salbu B, Heier L, Teien H, Lind O, Oughton D, et al. Early stress responses in Atlantic salmon (Salmo salar) exposed to environmentally relevant concentrations of uranium. Aquat Toxicol. 2012;112-113:62-71 pubmed publisher
    ..25 mg/L, giving rise to clear induction of several toxicologically relevant biomarker genes, although no significant adverse effects were observed after the relatively short exposure period. ..