Experts and Doctors on osteogenesis in China


Locale: China
Topic: osteogenesis

Top Publications

  1. Rui Y, Lui P, Wong Y, Tan Q, Chan K. Altered fate of tendon-derived stem cells isolated from a failed tendon-healing animal model of tendinopathy. Stem Cells Dev. 2013;22:1076-85 pubmed publisher
  2. Zhao J, Zhang P, Qin L, Pan X. Hypoxia is essential for bone-tendon junction healing: the molecular biological evidence. Int Orthop. 2011;35:925-8 pubmed publisher
    ..In this paper, the potential relationship between hypoxia and BTJ healing is discussed. Moreover, an operation model and possible drug application to obtain hypoxic conditions are delineated. ..
  3. Wen Y, Jiang B, Cui J, Li G, Yu M, Wang F, et al. Superior osteogenic capacity of different mesenchymal stem cells for bone tissue engineering. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:e324-32 pubmed publisher
    ..Our results suggested that hUC-MSCs and hAD-MSCs could be used for bone tissue engineering effectively; hUC-MSCs could serve as a new alternative cell source. ..
  4. Ren C, McGrath C, Jin L, Zhang C, Yang Y. Effect of diode low-level lasers on fibroblasts derived from human periodontal tissue: a systematic review of in vitro studies. Lasers Med Sci. 2016;31:1493-510 pubmed publisher
    ..However, further in vitro studies with better designs and more appropriate study models and laser parameters are anticipated to provide sound evidence for clinical studies and practice. ..
  5. Niu L, Jiao K, Qi Y, Nikonov S, Yiu C, Arola D, et al. Intrafibrillar silicification of collagen scaffolds for sustained release of stem cell homing chemokine in hard tissue regeneration. FASEB J. 2012;26:4517-29 pubmed publisher
    ..Intrafibrillar-silicified collagen scaffolds with sustained SDF-1? release represent a less costly and complex alternative to contemporary cell seeding approaches and provide new therapeutic options for in situ hard tissue regeneration. ..
  6. Rabie A, Xiong H, Hagg U. Forward mandibular positioning enhances condylar adaptation in adult rats. Eur J Orthod. 2004;26:353-8 pubmed
    ..91 per cent. These findings indicate that forward mandibular positioning causes changes in the biophysical environment of the temporomandibular joint (TMJ) of adult rats that leads to condylar adaptation. ..
  7. Shao R, Quan R, Huang X, Wang T, Xie S, Gao H, et al. Evaluation of porous gradient hydroxyapatite/zirconia composites for repair of lumbar vertebra defect in dogs. J Biomater Appl. 2016;30:1312-21 pubmed publisher
    ..New porous gradient hydroxyapatite/zirconia composites can promote the repair of bony defect, and induce bone tissue to ingrow into the pores, which may be applied widely to the treatment of bony defect in the future. ..
  8. Li Y, Ma W, Feng Z, Wang Z, Zha N, Deng B, et al. Effects of irradiation on osteoblast-like cells on different titanium surfaces in vitro. J Biomed Mater Res B Appl Biomater. 2013;101:9-17 pubmed publisher
    ..This study revealed the effects of irradiation on osteoblasts in vitro on two titanium surfaces. MAO surface could be used in dental implants in irradiated bone due to enhanced adhesion ability and collagen secretion in osteoblasts. ..
  9. Tang G, Rabie A. Runx2 regulates endochondral ossification in condyle during mandibular advancement. J Dent Res. 2005;84:166-71 pubmed
    ..Thus, Runx2 mediates chondrocyte terminal maturation and endochondral ossification in the mandibular condyle in response to mandibular advancement. ..

More Information


  1. Wang Q, Chen B, Cao M, Sun J, Wu H, Zhao P, et al. Response of MAPK pathway to iron oxide nanoparticles in vitro treatment promotes osteogenic differentiation of hBMSCs. Biomaterials. 2016;86:11-20 pubmed publisher
    ..In summary, the present study elucidates a molecular basis explaining how IONPs effect on hBMSCs, which could have many meaningful impacts for stem cells application in regenerative medicine. ..
  2. Chen S, Wang X, Xie X, Zheng L, Yao D, Wang D, et al. Comparative study of osteogenic potential of a composite scaffold incorporating either endogenous bone morphogenetic protein-2 or exogenous phytomolecule icaritin: an in vitro efficacy study. Acta Biomater. 2012;8:3128-37 pubmed publisher
    ..The results suggest that PLGA/TCP composite scaffolds incorporating osteogenic ICT might be a promising approach for bone tissue bioengineering and regeneration. ..
  3. Jing H, Liao L, An Y, Su X, Liu S, Shuai Y, et al. Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis. Mol Ther. 2016;24:217-229 pubmed publisher
    ..We also provided EZH2 as a novel therapeutic target for improving bone formation during osteoporosis. ..
  4. Rabie A, Hagg U. Factors regulating mandibular condylar growth. Am J Orthod Dentofacial Orthop. 2002;122:401-9 pubmed
    ..Condylar growth involves a sequence of transitory stages uniquely defined by molecules that are intrinsically synthesized by cells in the condyles. ..
  5. Wu Y, Wu T, Xu B, Xu X, Chen H, Li X, et al. Protocatechuic acid inhibits osteoclast differentiation and stimulates apoptosis in mature osteoclasts. Biomed Pharmacother. 2016;82:399-405 pubmed publisher
    ..The present findings shows evidence that, protocatechuic acid prevents osteoclast differentiation through regulating oxidative stress, inflammation and inducing apoptosis in RAW264.7 murine macrophage cells. ..
  6. Wu G, Feng C, Hui G, Wang Z, Tan J, Luo L, et al. Improving the osteogenesis of rat mesenchymal stem cells by chitosan-based-microRNA nanoparticles. Carbohydr Polym. 2016;138:49-58 pubmed publisher
    ..Above results demonstrated that CTH NPs was a potential candidate as an efficient non-viral miRNA vector to regulate the osteogenic differentiation of MSCs. ..
  7. He L, Duan H, Li X, Wang S, Zhang Y, Lei L, et al. Sinomenine down-regulates TLR4/TRAF6 expression and attenuates lipopolysaccharide-induced osteoclastogenesis and osteolysis. Eur J Pharmacol. 2016;779:66-79 pubmed publisher
  8. Xu Q, Cui Y, Luan J, Zhou X, Li H, Han J. Exosomes from C2C12 myoblasts enhance osteogenic differentiation of MC3T3-E1 pre-osteoblasts by delivering miR-27a-3p. Biochem Biophys Res Commun. 2018;498:32-37 pubmed publisher
  9. Zhang Z, Luo S. [The role of Wnt5b in the promotion of osteogenic differentiation by puerarin]. Shanghai Kou Qiang Yi Xue. 2016;25:187-90 pubmed
    ..10(-5) mol/L group showed the best effect. Puerarin can induce BMMSCs differentiation into osteoblasts. The mechanism may be related to Wnt signaling pathway. ..
  10. Wang Z, Li Z, Dai T, Zong C, Liu Y, Liu B. Addition of Adipose-Derived Stem Cells to Mesenchymal Stem Cell Sheets Improves Bone Formation at an Ectopic Site. Int J Mol Sci. 2016;17: pubmed publisher
    ..Thus, the combination of MSC sheets with ADSCs may be regarded as a promising therapeutic strategy to stimulate bone regeneration. ..
  11. Wang L, Qin L, Cheung W, Lu H, Yang X, Leung K, et al. A delayed bone-tendon junction healing model established for potential treatment of related sports injuries. Br J Sports Med. 2010;44:114-20 pubmed publisher
    ..The healing quality was also reflected by histological findings. A delayed B-T healing experimental model was established for the first time for future sports medicine research. ..
  12. Tso G, Law H, Tu W, Chan G, Lau Y. Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Stem Cells. 2010;28:939-54 pubmed publisher
    ..This data provide a novel insight on the role of AC in modulating MSC osteogenic differentiation and function in inflammatory bone diseases. ..
  13. Qin L, Wang L, Wong M, Wen C, Wang G, Zhang G, et al. Osteogenesis induced by extracorporeal shockwave in treatment of delayed osteotendinous junction healing. J Orthop Res. 2010;28:70-6 pubmed publisher
    ..These findings formed a scientific basis to potential clinical application of ESW for treatment of delayed OTJ healing. ..
  14. Shao W, He J, Sang F, Wang Q, Chen L, Cui S, et al. Enhanced bone formation in electrospun poly(L-lactic-co-glycolic acid)-tussah silk fibroin ultrafine nanofiber scaffolds incorporated with graphene oxide. Mater Sci Eng C Mater Biol Appl. 2016;62:823-34 pubmed publisher
    ..The results indicate that composite nanofibers could be excellent and versatile scaffolds for bone tissue engineering. ..
  15. Liu X, Zhou L, Chen X, Liu T, Pan G, Cui W, et al. Culturing on decellularized extracellular matrix enhances antioxidant properties of human umbilical cord-derived mesenchymal stem cells. Mater Sci Eng C Mater Biol Appl. 2016;61:437-48 pubmed publisher
    ..Collectively, by providing sufficient cell amounts and enhancing antioxidant capacity, decellularized ECM can be a promising cell culture platform for in vitro expansion of UC-MSCs. ..
  16. You W, Gao H, Fan L, Duan D, Wang C, Wang K. Foxc2 regulates osteogenesis and angiogenesis of bone marrow mesenchymal stem cells. BMC Musculoskelet Disord. 2013;14:199 pubmed publisher
    ..The overexpression of Foxc2 acts on BMSCs to stimulate osteogenesis and angiogenesis. The effect of Foxc2 on angiogenesis of the cells is mediated via activating PI3K and ERK. ..
  17. Dai J, Rabie A. VEGF: an essential mediator of both angiogenesis and endochondral ossification. J Dent Res. 2007;86:937-50 pubmed
  18. Zhou J, Li B, Lu S, Zhang L, Han Y. Regulation of osteoblast proliferation and differentiation by interrod spacing of Sr-HA nanorods on microporous titania coatings. ACS Appl Mater Interfaces. 2013;5:5358-65 pubmed publisher
    ..Our work provides insight to the surface structural design of a biomedical implant favoring osteointegration. ..
  19. Yu F, Cui Y, Zhou X, Zhang X, Han J. Osteogenic differentiation of human ligament fibroblasts induced by conditioned medium of osteoclast-like cells. Biosci Trends. 2011;5:46-51 pubmed
    ..The current results suggest that osteoclasts might induce the osteogenic differentiation of fibroblasts in vitro and that miRNA may play an important role in regulation of the cell-cell interaction between osteoclasts and fibroblasts. ..
  20. Qu Y, Yang Y, Li J, Chen Z, Li J, Tang K, et al. Preliminary evaluation of a novel strong/osteoinductive calcium phosphate cement. J Biomater Appl. 2011;26:311-25 pubmed publisher
    ..Therefore, the novel CPC scaffold may be potentially useful for implant fixation and more rapid new bone formation in moderate load-bearing applications. ..
  21. Zheng J, He L, Hu T. [The relationship between the effects of MTA on mRNA expression of four iconic proteins in cells of fetal rat skull and cell culture environment]. Shanghai Kou Qiang Yi Xue. 2016;25:16-21 pubmed
    ..At the same time, the expression of ALPmRNA, BGPmRNA, Col ? mRNA and Cbfalpha lmRNA were regulated accordingly, which is the key to explain osteogenetic mechanism of MTA. ..
  22. Wang Z, Feng Z, Wu G, Bai S, Dong Y, Zhao Y. In vitro studies on human periodontal ligament stem cell sheets enhanced by enamel matrix derivative. Colloids Surf B Biointerfaces. 2016;141:102-111 pubmed publisher
    ..These EMD-enhanced cell sheets may represent a potential option for stem-cell therapy for PDL regeneration. ..
  23. Xiao Y, Cui J, Li Y, Shi Y, Le G. Expression of genes associated with bone resorption is increased and bone formation is decreased in mice fed a high-fat diet. Lipids. 2010;45:345-55 pubmed publisher
    ..These results indicate that an HFD may induce inhibitory bone formation and enhanced bone resorption, thus causing adverse bone status. ..
  24. Wei Y, Fang J, Cai S, Lv C, Zhang S, Hua J. Primordial germ cell-like cells derived from canine adipose mesenchymal stem cells. Cell Prolif. 2016;49:503-11 pubmed publisher
    ..Quantitative real-time PCR (qRT-PCR) and western blotting analysis verified higher expression levels of these markers. This study provides an efficient approach to study germ cell development using CAMSCs. ..
  25. Peng S, Liu X, Wang T, Li Z, Zhou G, Luk K, et al. In vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cells. J Orthop Res. 2010;28:1208-14 pubmed publisher
    ..The effect of Sr on rat BMSCs was reproducible in human BMSCs. Taken together, this study suggests that the anabolic effect of Sr on normal or osteoporotic bones is associated with increased osteoblastic differentiation of BMSCs. ..
  26. Ni M, Rui Y, Tan Q, Liu Y, Xu L, Chan K, et al. Engineered scaffold-free tendon tissue produced by tendon-derived stem cells. Biomaterials. 2013;34:2024-37 pubmed publisher
    ..In conclusion, this is a proof-of-concept study demonstrating that ESFTT could be a potentially new approach for tendon repair and regeneration. ..
  27. Wang Y, Yan M, Wang Z, Wu J, Wang Z, Zheng Y, et al. Dental pulp stem cells from traumatically exposed pulps exhibited an enhanced osteogenic potential and weakened odontogenic capacity. Arch Oral Biol. 2013;58:1709-17 pubmed publisher
    ..This study was designed to evaluate the effects of traumatic pulp exposure on the osteo/odontogenic capacity of dental pulp stem cells (DPSCs)...
  28. Li K, Xu L, Huang S, Zhang D. [Effect of NaF on proliferation and mineralization of human periodontal ligament cells]. Shanghai Kou Qiang Yi Xue. 2017;26:48-53 pubmed
    ..5×10-5, 1×10-4, 5×10-4 mol/L NaF can stimulate proliferation in hPDLCs, 1×10-5 mol/L NaF can enhance ALP activity and calcium content formation of hPDLCs. ..
  29. Wei K, Xie Y, Chen T, Fu B, Cui S, Wang Y, et al. ERK1/2 signaling mediated naringin-induced osteogenic differentiation of immortalized human periodontal ligament stem cells. Biochem Biophys Res Commun. 2017;489:319-325 pubmed publisher
  30. Zhao X, Deng P, Feng J, Wang Z, Xiang Z, Han X, et al. Cysteine Dioxygenase Type 1 Inhibits Osteogenesis by Regulating Wnt Signaling in Primary Mouse Bone Marrow Stromal Cells. Sci Rep. 2016;6:19296 pubmed publisher
    ..Collectively, our findings indicate Cdo1 suppresses osteogenic differentiation of BMSCs, through a potential mechanism which involves in Wnt signaling reduction concomitantly. ..
  31. Wang Y, Zhang H, Han H, Zou Y, Gao Q, Yang G. Taxifolin enhances osteogenic differentiation of human bone marrow mesenchymal stem cells partially via NF-?B pathway. Biochem Biophys Res Commun. 2017;490:36-43 pubmed publisher
    ..In conclusion, our results suggested that taxifolin could promote osteogenesis of hBMSCs, partially through antagonism of NF-?B signaling pathway. ..
  32. Zhang Q, Lin S, Zhang T, Tian T, Ma Q, Xie X, et al. Curved microstructures promote osteogenesis of mesenchymal stem cells via the RhoA/ROCK pathway. Cell Prolif. 2017;50: pubmed publisher
    ..However, it is not clear how curved microstructures affect cellular behaviour in bone tissue...
  33. Wang D, Li F, Jiang Z. Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids. Planta Med. 2001;67:748-9 pubmed
    ..The results suggested that Psoralea corylifolia L. fruit extracts and corylin and bavachin might stimulate bone formation or have potential activity against osteoporosis...
  34. Wang H, Mao Y, Zhang B, Wang T, Li F, Fu S, et al. Chloride channel ClC-3 promotion of osteogenic differentiation through Runx2. J Cell Biochem. 2010;111:49-58 pubmed publisher
    ..The data from the current study suggest that the function of ClC-3 in osteodifferentiation may be through the Runx2 pathway. ..
  35. Pan F, Zhang R, Wang G, Ding Y. Oestrogen receptors are involved in the osteogenic differentiation of periodontal ligament stem cells. Biosci Rep. 2011;31:117-24 pubmed publisher
    ..The results indicate that both ER? and ER? were involved in the process of osteogenic differentiation of PDLSCs. ..
  36. Wu N, Zhao Y, Yin Y, Zhang Y, Luo J. Identification and analysis of type II TGF-? receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai). 2010;42:699-708 pubmed publisher
    ..Taken together, our results demonstrated that BMPRII and ActRII are the functional type II TGF-? receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 cells. ..
  37. Lui P, Lee Y, Wong Y, Zhang X, Dai K, Rolf C. Expression of Wnt pathway mediators in metaplasic tissue in animal model and clinical samples of tendinopathy. Rheumatology (Oxford). 2013;52:1609-18 pubmed publisher
    ..Activation of the Wnt signalling pathway and its effect on TDSCs might contribute to tissue metaplasia and failed healing in some cases of tendinopathy. ..
  38. Xu L, Zhang G, Zhou Y, Chen Y, Xu W, Wu S, et al. Stimulation of B7-H3 (CD276) directs the differentiation of human marrow stromal cells to osteoblasts. Immunobiology. 2011;216:1311-7 pubmed publisher
    ..Furthermore, our study also shows that stimulation of B7-H3 increases the expression of osteoprotein (OPG), and decreases the expression of its cognate ligand, the receptor activator of nuclear factor kappaB ligand (RANKL). ..
  39. Wang Y, Wang H, Ye Q, Ye J, Xu C, Lin L, et al. Co-regulation of LPS and tensile strain downregulating osteogenicity via c-fos expression. Life Sci. 2013;93:38-43 pubmed publisher
    ..In addition, inflammation may reduce the ability of osteoblasts to restore their osteogenic capacity during sustained tensile stress and contribute to periodontium damage. ..
  40. Wang L, Qin L, Lu H, Cheung W, Yang H, Wong W, et al. Extracorporeal shock wave therapy in treatment of delayed bone-tendon healing. Am J Sports Med. 2008;36:340-7 pubmed
    ..These results provide a foundation for future clinical studies toward establishment of clinical indication for treatment of delayed bone-to-tendon junction healing. ..
  41. Ji K, Liu Y, Lu W, Yang F, Yu J, Wang X, et al. Periodontal tissue engineering with stem cells from the periodontal ligament of human retained deciduous teeth. J Periodontal Res. 2013;48:105-16 pubmed publisher
    ..However, little knowledge is available on the periodontal ligament stem cells from human retained deciduous teeth (DePDLSCs). This study evaluated the potential of DePDLSCs in periodontal tissue regeneration...
  42. Li M, Yang X, Wang W, Zhang Y, Wan P, Yang K, et al. Evaluation of the osteo-inductive potential of hollow three-dimensional magnesium-strontium substitutes for the bone grafting application. Mater Sci Eng C Mater Biol Appl. 2017;73:347-356 pubmed publisher
  43. Ding Y, Yang H, Wang Y, Chen J, Ji Z, Sun H. Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1?-SOD2-mediated regulation of mitochondrial function. Int J Biol Sci. 2017;13:254-264 pubmed publisher
    ..Overall, the data provide a better understanding of the role of SIRT3 in osteogenic differentiation. ..
  44. Xu Y, Sun J, Yang X, Yu Y, Mai H, Li Z. Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/?-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. J Oral Maxillofac Surg. 2017;75:2135-2143 pubmed publisher
    ..Wnt3a, a Wnt and ?-catenin signaling activator, reversed the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs. ..
  45. Yin J, Zhuang G, Zhu Y, Hu X, Zhao H, Zhang R, et al. MiR-615-3p inhibits the osteogenic differentiation of human lumbar ligamentum flavum cells via suppression of osteogenic regulators GDF5 and FOXO1. Cell Biol Int. 2017;41:779-786 pubmed publisher
    ..In conclusion, miR-615-3p negatively regulates the osteogenic differentiation of hLF cells through post-transcriptionally suppressing osteogenic regulators GDF5 and FOXO1. It can be regarded as a potential target for human OLF therapy. ..
  46. Deng Z, Peng S, Zheng Y, Yang X, Zhang H, Tan Q, et al. Estradiol activates chloride channels via estrogen receptor-? in the cell membranes of osteoblasts. Am J Physiol Cell Physiol. 2017;313:C162-C172 pubmed publisher
  47. Peng S, Songlin P, Zhang G, Ge Z, He Y, Yixin H, et al. Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone. Bone. 2009;45:534-44 pubmed publisher
    ..Epimedium-derived flavonoids (EFs) have been reported to prevent bone loss in ovariectomized (OVX) rats and late postmenopausal women but the underlying mechanism of the anabolic effect is unknown...
  48. Rui Y, Lui P, Lee Y, Chan K. Higher BMP receptor expression and BMP-2-induced osteogenic differentiation in tendon-derived stem cells compared with bone-marrow-derived mesenchymal stem cells. Int Orthop. 2012;36:1099-107 pubmed publisher
    ..The use of BMP-2 to promote TBJ repair has been well reported. This study aimed to compare TDSCs to the gold standard bone-marrow-derived mesenchymal stem cells (BMSCs) with respect to osteogenic response to BMP-2 in vitro...
  49. Hu J, Liao H, Ma Z, Chen H, Huang Z, Zhang Y, et al. Focal Adhesion Kinase Signaling Mediated the Enhancement of Osteogenesis of Human Mesenchymal Stem Cells Induced by Extracorporeal Shockwave. Sci Rep. 2016;6:20875 pubmed publisher
  50. Jing H, Liao L, Su X, Shuai Y, Zhang X, Deng Z, et al. Declining histone acetyltransferase GCN5 represses BMSC-mediated angiogenesis during osteoporosis. FASEB J. 2017;31:4422-4433 pubmed publisher
    ..Jing, H., Liao, L., Su, X., Shuai, Y. Zhang, X., Deng, Z., Jin, Y. Declining histone acetyltransferase GCN5 represses BMSC-mediated angiogenesis during osteoporosis. ..
  51. Lin G, Wang H, Dai J, Li X, Guan M, Gao S, et al. Conjugated linoleic acid prevents age-induced bone loss in mice by regulating both osteoblastogenesis and adipogenesis. Biochem Biophys Res Commun. 2017;490:813-820 pubmed publisher
    ..Overall CLA thus be a suitable candidate for the treatment of patients with postmenopausal osteoporosis and obesity. ..
  52. Li C, Yang X, He Y, Ye G, Li X, Zhang X, et al. Bone morphogenetic protein-9 induces osteogenic differentiation of rat dental follicle stem cells in P38 and ERK1/2 MAPK dependent manner. Int J Med Sci. 2012;9:862-71 pubmed publisher
    ..Detection of ALP and calcium deposition revealed the BMP-9 induced osteogenic differentiation of dental follicle stem cells depended on MAPK signaling pathway. ..
  53. Kong L, Yang C, Yu L, Smith W, Zhu S, Zhu J, et al. Pyrroloquinoline quinine inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos in mouse bone marrow cells and inhibits wear particle-induced osteolysis in mice. PLoS ONE. 2013;8:e61013 pubmed publisher
  54. Xie X, Zhan X, Hu Z. [Zinc finger protein 521 suppresses osteogenic differentiation of rat mesenchymal stem cells by inhibiting the Wnt/beta-catenin signaling pathway]. Mol Biol (Mosk). 2017;51:464-472 pubmed publisher
    ..Therefore, we conclude that Zfp521 regulates osteogenic differentiation of rat MSCs through the suppression of the Wnt/beta-catenin signaling pathway. ..
  55. Li Y, Fan L, Hu J, Zhang L, Liao L, Liu S, et al. MiR-26a Rescues Bone Regeneration Deficiency of Mesenchymal Stem Cells Derived From Osteoporotic Mice. Mol Ther. 2015;23:1349-1357 pubmed publisher
    ..Our findings indicate that miR-26a may be a promising therapeutic candidate to enhance bone formation in treatment of osteoporosis and to promote bone regeneration in osteoporotic fracture healing. ..
  56. Li X, Peng B, Zhu X, Wang P, Xiong Y, Liu H, et al. Changes in related circular RNAs following ER? knockdown and the relationship to rBMSC osteogenesis. Biochem Biophys Res Commun. 2017;493:100-107 pubmed publisher
    ..This research suggested that ER? may through 2:27713879|27755789/2:240822115|240867796-miR-328-5p-mRNA axis to regulate osteogenic differentiation. ..
  57. Zhao Q, Wang S, Liu S, Li J, Zhang Y, Sun Z, et al. PPAR? forms a bridge between DNA methylation and histone acetylation at the C/EBP? gene promoter to regulate the balance between osteogenesis and adipogenesis of bone marrow stromal cells. FEBS J. 2013;280:5801-14 pubmed publisher
  58. Wang L, Lee W, Lei D, Liu Y, Yamashita D, Yen S. Tisssue responses in corticotomy- and osteotomy-assisted tooth movements in rats: histology and immunostaining. Am J Orthod Dentofacial Orthop. 2009;136:770.e1-11; discussion 770-1 pubmed publisher
    ..The purpose of this histologic study was to examine underlying cellular responses to corticotomy- and osteotomy-assisted tooth movements...
  59. Zhang D, Li L, Hu Y. A novel TAT fusion protein with osteoinductive activity. Med Hypotheses. 2007;68:1009-11 pubmed
    ..If the hypothesis proved to be practical, we would have a more effective new way to promote bone repair and regeneration. ..
  60. Liu G, Ma C, Wang P, Zhang P, Qu X, Liu S, et al. Pilose antler peptide potentiates osteoblast differentiation and inhibits osteoclastogenesis via manipulating the NF-?B pathway. Biochem Biophys Res Commun. 2017;491:388-395 pubmed publisher
    ..Therefore, PAP, a novel drug with both antiresorptive and osteoanabolic activity, shows therapeutic potential as an alternative treatment for osteolytic diseases, including rheumatoid arthritis and osteoporosis. ..
  61. Zhang Y, Wei Q, Ding W, Zhang L, Wang H, Zhu Y, et al. Increased microRNA-93-5p inhibits osteogenic differentiation by targeting bone morphogenetic protein-2. PLoS ONE. 2017;12:e0182678 pubmed publisher
    ..Our study showed that increased miR-93-5p in TIONFH patients inhibited osteogenic differentiation, which may be associated with BMP-2 reduction. Therefore, miR-93-5p may be a potential target for prevention of TIONFH. ..
  62. Chen F, Mao T, Tao K, Chen S, Ding G, Gu X. Bone graft in the shape of human mandibular condyle reconstruction via seeding marrow-derived osteoblasts into porous coral in a nude mice model. J Oral Maxillofac Surg. 2002;60:1155-9 pubmed
  63. Rui Y, Lui P, Ni M, Chan L, Lee Y, Chan K. Mechanical loading increased BMP-2 expression which promoted osteogenic differentiation of tendon-derived stem cells. J Orthop Res. 2011;29:390-6 pubmed publisher
    ..Activation of BMP-2 expression in TDSCs during tendon overuse might provide a possible explanation of ectopic calcification in calcifying tendinopathy. ..
  64. Ko C, Siu W, Wong H, Shum W, Fung K, San Lau C, et al. Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro. J Agric Food Chem. 2011;59:9870-6 pubmed publisher
    ..Our results provide scientific evidence to support the potential use of green tea in supporting the bone against degenerative diseases such as osteoporosis. ..
  65. Xu Y, Xu B, Wu C, Wu Y, Tong P, Xiao L. Dynamic expression of DKK1 protein in the process whereby Epimedium-derived flavonoids up-regulate osteogenic and down-regulate adipogenic differentiation of bone marrow stromal cells in ovariectomized rats. Orthop Surg. 2011;3:119-26 pubmed publisher
    ..This may be an important molecular mechanism of EFs in the context of treatment of postmenopausal osteoporosis. ..
  66. Meng J, Ma X, Wang N, Jia M, Bi L, Wang Y, et al. Activation of GLP-1 Receptor Promotes Bone Marrow Stromal Cell Osteogenic Differentiation through β-Catenin. Stem Cell Reports. 2016;6:579-591 pubmed publisher
    ..These findings reveal that GLP-1 receptor regulates BMSC osteogenic differentiation and provide a molecular basis for therapeutic potential of GLP-1 against osteoporosis. ..
  67. Wang N, Zhou Z, Wu T, Liu W, Yin P, Pan C, et al. TNF-α-induced NF-κB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting β-catenin. Open Biol. 2016;6: pubmed publisher
  68. Zhang Y, Cui Y, Luan J, Zhou X, Zhang G, Han J. Platelet-derived growth factor receptor kinase inhibitor AG-1295 promotes osteoblast differentiation in MC3T3-E1 cells via the Erk pathway. Biosci Trends. 2012;6:130-5 pubmed publisher
  69. Sang C, Zhang Y, Chen F, Huang P, Qi J, Wang P, et al. Tumor necrosis factor alpha suppresses osteogenic differentiation of MSCs by inhibiting semaphorin 3B via Wnt/β-catenin signaling in estrogen-deficiency induced osteoporosis. Bone. 2016;84:78-87 pubmed publisher
    ..This study may indicate a therapeutic target gene of Semaphorin3B for osteoporosis. ..
  70. Wang J, Qiang Z, Zhu Q, Song S, Shi L, Ma C, et al. Temporal expression of Pelp1 during proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells. PLoS ONE. 2013;8:e75477 pubmed publisher
    ..Pelp1 may be a key player in BMSCs proliferation and osteogenic differentiation, meriting further consideration as a target for development of therapies for pathological bone loss conditions, such as menopausal bone loss. ..
  71. Wang H, Chen Q, Liu W, Yang Z, Li D, Jin F. [Effect of trichostatin A on the osteogenic differentiation potential of periodontal ligament stem cells in inflammatory microenvironment induced by tumor necrosis factor-? stimulation]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2016;51:235-41 pubmed publisher
    ..TSA, as a histone deacetylase inhibitor, could significantly promote the osteogenic differentiation potential of PDLSC in inflammatory microenvironment by suppressing HDAC. ..
  72. Cheng W, Han X, Mou S, Yang F, Liu L. [Effects of alginate/collagen scaffold on cell proliferation and differentiation of human adipose-derived mesenchymal stem cells]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2017;52:259-264 pubmed publisher
    ..Bone tissue engineering can use 10% hydrogel material, and when the sodium alginate and collagen have a ratio of 2?1, the hydrogel can be conducive to cell differentiation and proliferation...
  73. Deng Y, Wu A, Li P, Li G, Qin L, Song H, et al. Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair. Cell Rep. 2016;14:2224-2237 pubmed publisher
    ..Taken together, our work provides insights into the mechanism by which Yap1 regulates endochondral ossification, which may help the development of therapeutic treatment for bone regeneration. ..
  74. Zhao L, Wang H, Huo K, Zhang X, Wang W, Zhang Y, et al. The osteogenic activity of strontium loaded titania nanotube arrays on titanium substrates. Biomaterials. 2013;34:19-29 pubmed publisher
    ..NT10-Sr3 which shows excellent osteogenic properties is very attractive and has large clinical potential...
  75. Sun L, Guo W, Yin C, Zhang S, Qu G, Hou Y, et al. Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload. Gene. 2014;543:161-5 pubmed publisher
    ..Targeting hepcidin or the pathway it modulates may thus represent a therapeutic for osteopenia or osteoporosis...
  76. Qu X, Zhai Z, Liu X, Li H, Ouyang Z, Wu C, et al. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun. 2014;443:658-65 pubmed publisher
    ..Together our data demonstrate that dioscin suppressed RANKL-induced osteoclast formation and function through Akt signaling cascades. Therefore, dioscin is a potential natural agent for the treatment of osteoclast-related diseases. ..
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    ..This study revealed the C/EBPalpha promoter methylation mechanism and evaluated the function of Wnt/beta-catenin pathway in Dex-induced osteoporosis, providing a useful therapeutic target for this type of osteoporosis. ..