Experts and Doctors on ornithine in Japan


Locale: Japan
Topic: ornithine

Top Publications

  1. Aoyagi K. Inhibition of arginine synthesis by urea: a mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation. Mol Cell Biochem. 2003;244:11-5 pubmed
    ..This may, also, be an explanation for the reported increase in oxygen stress in renal failure. ..
  2. Koga R, Miyoshi Y, Sato Y, Mita M, Konno R, Lindner W, et al. Enantioselective determination of citrulline and ornithine in the urine of d-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system. J Chromatogr A. 2016;1467:312-317 pubmed publisher
    ..These results were definitely confirmed by a 2D-HPLC-MS detection system. Further investigations about the biological significance of these d-isomers are currently ongoing. ..
  3. Kimura T, Chowdhury S, Tanaka T, Shimizu A, Iwase K, Oyadomari S, et al. CCAAT/enhancer-binding protein beta is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes. FEBS Lett. 2001;494:105-11 pubmed
    ..Therefore, C/EBPbeta is required for hormonal induction of the genes for ornithine cycle enzymes in primary-cultured hepatocytes, while the deficiency of C/EBPbeta is compensated for in vivo. ..
  4. Maneerat S, Bamba T, Harada K, Kobayashi A, Yamada H, Kawai F. A novel crude oil emulsifier excreted in the culture supernatant of a marine bacterium, Myroides sp. strain SM1. Appl Microbiol Biotechnol. 2006;70:254-9 pubmed
  5. Hayasaka S, Kodama T, Ohira A. Retinal risks of high-dose ornithine supplements: a review. Br J Nutr. 2011;106:801-11 pubmed publisher
  6. Kashiwagi K, Watanabe R, Igarashi K. Involvement of ribonuclease III in the enhancement of expression of the speF-potE operon encoding inducible ornithine decarboxylase and polyamine transport protein. Biochem Biophys Res Commun. 1994;200:591-7 pubmed
    ..This is the first example that RNase III increases the translational efficiency of mRNA derived from Escherichia coli gene by cutting the 5'-untranslated region of mRNA. ..
  7. Kashiwagi K, Miyamoto S, Suzuki F, Kobayashi H, Igarashi K. Excretion of putrescine by the putrescine-ornithine antiporter encoded by the potE gene of Escherichia coli. Proc Natl Acad Sci U S A. 1992;89:4529-33 pubmed
    ..When intact E. coli was used instead of the inside-out membrane vesicles, excretion of putrescine was also catalyzed by the antiport protein in the presence of ornithine in the medium. ..
  8. Sawada H, Takeuchi T, Matsuda I. Comparative analysis of Pseudomonas syringae pv. actinidiae and pv. phaseolicola based on phaseolotoxin-resistant ornithine carbamoyltransferase gene (argK) and 16S-23S rRNA intergenic spacer sequences. Appl Environ Microbiol. 1997;63:282-8 pubmed
    ..syringae pv. actinidiae and/or pv. phaseolicola...
  9. Nishijyo T, Park S, Lu C, Itoh Y, Abdelal A. Molecular characterization and regulation of an operon encoding a system for transport of arginine and ornithine and the ArgR regulatory protein in Pseudomonas aeruginosa. J Bacteriol. 1998;180:5559-66 pubmed
    ..aeruginosa. Sequence alignment confirms the architecture and the consensus sequence of the ArgR binding sites, as was previously reported. ..

More Information


  1. Li M, Nakajima T, Fukushige T, Kobayashi K, Seiler N, Saheki T. Aberrations of ammonia metabolism in ornithine carbamoyltransferase-deficient spf-ash mice and their prevention by treatment with urea cycle intermediate amino acids and an ornithine aminotransferase inactivator. Biochim Biophys Acta. 1999;1455:1-11 pubmed
  2. Sawada H, Suzuki F, Matsuda I, Saitou N. Phylogenetic analysis of Pseudomonas syringae pathovars suggests the horizontal gene transfer of argK and the evolutionary stability of hrp gene cluster. J Mol Evol. 1999;49:627-44 pubmed
  3. Sawada H, Kanaya S, Tsuda M, Suzuki F, Azegami K, Saitou N. A phylogenomic study of the OCTase genes in Pseudomonas syringae pathovars: the horizontal transfer of the argK-tox cluster and the evolutionary history of OCTase genes on their genomes. J Mol Evol. 2002;54:437-57 pubmed publisher
    ..Thus, the horizontal gene transfer and the genomic rearrangement were proven to have played an important role in the pathogenic differentiation and diversification of P. syringae...
  4. Zhang G, Kimura S, Murao K, Shimizu J, Matsuyoshi H, Takaki M. Role of neuronal NO synthase in regulating vascular superoxide levels and mitogen-activated protein kinase phosphorylation. Cardiovasc Res. 2009;81:389-99 pubmed publisher
    ..The generated O2(-) may react with NO to form peroxynitrite (ONOO(-)). Both O2(-) and ONOO(-) participate in Ang II-induced activation of vascular MAPK. ..
  5. Ho Y, Nakato J, Mizushige T, Kanamoto R, Tanida M, Akiduki S, et al. l-Ornithine stimulates growth hormone release in a manner dependent on the ghrelin system. Food Funct. 2017;8:2110-2114 pubmed publisher
    ..In conclusion, intraduodenally administered l-Orn stimulates GH secretion through the sympathetic nervous and ghrelin systems. ..