Experts and Doctors on organic cation transporter 1 in United States
Locale: United States
Topic: organic cation transporter 1
Cherrington N, Slitt A, Li N, Klaassen C. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos. 2004;32:734-41 pubmed
..The concurrent repression and induction of various transporters, as well as dexamethasone abatement of both LPS-mediated repression and induction, indicates that these responses may be mediated through similar pathways. ..
Chien H, Zur A, Maurer T, Yee S, Tolsma J, Jasper P, et al
. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells. Drug Metab Dispos. 2016;44:356-64 pubmed publisher
..This method together with the computational model can be used to determine intracellular unbound concentrations and to predict subcellular accumulation of drugs in other complex systems such as primary cells. ..
Slitt A, Cherrington N, Hartley D, Leazer T, Klaassen C. Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Drug Metab Dispos. 2002;30:212-9 pubmed
..In summary, OCT mRNA was detected primarily in kidney, and the high level of renal OCT expression may explain why the kidney is a target organ for xenobiotics with cationic properties. ..
Sprowl J, Ong S, Gibson A, Hu S, Du G, Lin W, et al
. A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016;7:10880 pubmed publisher