Genomes and Genes
Experts and Doctors on organ specificity in United States
Locale: United States
Topic: organ specificity
Publications321 found, 100 shown here
- Buggs R, Elliott N, Zhang L, Koh J, Viccini L, Soltis D, et al. Tissue-specific silencing of homoeologs in natural populations of the recent allopolyploid Tragopogon mirus. New Phytol. 2010;186:175-83 pubmed publisher..Our study shows that tissue-specific silencing, and even apparent subfunctionalization, can arise rapidly in the early generations of natural allopolyploidy...
- Wu X, Subramaniam M, Negron V, Cicek M, Reynolds C, Lingle W, et al. Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody. J Cell Biochem. 2012;113:711-23 pubmed publisher..The use of the MC10 antibody, in combination with highly specific antibodies targeting only full-length ER?, is likely to provide additional discriminatory features in breast cancers that may be useful in predicting response to therapy. ..
- McCue A, Nuthikattu S, Reeder S, Slotkin R. Gene expression and stress response mediated by the epigenetic regulation of a transposable element small RNA. PLoS Genet. 2012;8:e1002474 pubmed publisher..In addition, the ability of this TE siRNA to regulate a gene's expression in trans blurs the lines between TE and gene-regulating small RNAs. ..
- Szafran B, Borazjani A, Lee J, Ross M, Kaplan B. Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation. Prostaglandins Other Lipid Mediat. 2015;121:199-206 pubmed publisher..These studies suggest that the endocannabinoid system could be activated via suppression of a 2-AG catabolic enzyme in response to inflammatory stimuli as one mechanism to limit inflammation. ..
- Wang D, Sadee W. CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing. Pharmacogenet Genomics. 2016;26:40-3 pubmed publisher..These results indicate that tissue-specific increased formation of nonfunctional alternative splice variant causes reduced CYP3A4 mRNA/protein expression in CYP3A4*22 carriers. ..
- Marinkovich M, Lunstrum G, Keene D, Burgeson R. The dermal-epidermal junction of human skin contains a novel laminin variant. J Cell Biol. 1992;119:695-703 pubmed..We propose the name K-laminin for this variant. ..
- Williams J, Thomas A, Li G, Kong B, Zhan L, Inaba Y, et al. Tissue specific induction of p62/Sqstm1 by farnesoid X receptor. PLoS ONE. 2012;7:e43961 pubmed publisher..Regulation of p62 by FXR indicates tissue-specific and gene-dosage effects. Furthermore, FXR-mediated induction of p62 may implicate a protective mechanism of FXR. ..
- Aroian R, Sternberg P. Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction. Genetics. 1991;128:251-67 pubmed..Since various let-23 mutant phenotypes can be obtained independently, the let-23 gene is likely to have tissue-specific functions. ..
- Choi Y, Gu W, Hecht N, Feinberg A, Chae C. Molecular cloning of mouse somatic and testis-specific H2B histone genes containing a methylated CpG island. DNA Cell Biol. 1996;15:495-504 pubmed..The unmethylation of both H2B histone genes in the testis explains how CpG islands of those histone genes can be maintained during evolution despite heavy methylation in somatic tissues. ..
- Holland P, Suzanne M, Campbell J, Noselli S, Cooper J. MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous. J Biol Chem. 1997;272:24994-8 pubmed..MKK7 directly phosphorylates and activates JNK/SAPK. Thus, MKK7 is a homolog of hep and functions in a conserved signaling pathway involving JNK/SAPK and the GTPase Rac1. ..
- Slitt A, Cherrington N, Hartley D, Leazer T, Klaassen C. Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Drug Metab Dispos. 2002;30:212-9 pubmed..In summary, OCT mRNA was detected primarily in kidney, and the high level of renal OCT expression may explain why the kidney is a target organ for xenobiotics with cationic properties. ..
- Luense L, Carletti M, Christenson L. Role of Dicer in female fertility. Trends Endocrinol Metab. 2009;20:265-72 pubmed publisher..This review discusses these early studies and other data describing the current understanding of microRNAs and small interfering RNAs in female reproduction. ..
- Wilber A, Tschulena U, Hargrove P, Kim Y, Persons D, Barbas C, et al. A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts. Blood. 2010;115:3033-41 pubmed publisher..These observations demonstrate the potential for sequence-specific enhancement of HbF in patients with beta-thalassemia or sickle cell anemia. ..
- Wang J, Liu Y, Li Z, Wang Z, Tan L, Ryu M, et al. Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood. 2011;118:368-79 pubmed publisher..Our data indicate that the tumor transformation potential of endogenous oncogenic Nras is both dose- and cell type-dependent. ..
- Zhang G, Xiang B, Dong A, Skoda R, Daugherty A, Smyth S, et al. Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood. 2011;118:3670-9 pubmed publisher..Together, our data demonstrate important roles of sGC in stimulating platelet activation and in vivo thrombosis and hemostasis, and sGC-dependent and -independent inhibition of platelets by NO donors. ..
- Park S, Wamsley H, Bae K, Hu Z, Li X, Choe S, et al. Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans. PLoS ONE. 2013;8:e59675 pubmed publisher..From this, we conclude that Jak2 plays an essential and non-redundant role in hematopoiesis during both prenatal and postnatal life and this has direct implications regarding the inhibition of Jak2 in humans. ..
- Braasch I, Gehrke A, Smith J, Kawasaki K, Manousaki T, Pasquier J, et al. The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nat Genet. 2016;48:427-37 pubmed publisher..The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences. ..
- Horlick R, Stack S, Cooke G. Cloning, expression and tissue distribution of the gene encoding rat fibroblast growth factor receptor subtype 4. Gene. 1992;120:291-5 pubmed..However, the acidic box and hydrophobic signal peptide domains are not present in this cDNA isolate. ..
- Nagavarapu U, Danthi S, Boyd R. Characterization of a rat neuronal nicotinic acetylcholine receptor alpha7 promoter. J Biol Chem. 2001;276:16749-57 pubmed..Several transcription factors interact in close proximity to control expression of the rat alpha7 nicotinic receptor gene. ..
- Sheflin L, Zhang W, Spaulding S. Androgen regulates the level and subcellular distribution of the AU-rich ribonucleic acid-binding protein HuR both in vitro and in vivo. Endocrinology. 2001;142:2361-8 pubmed
- Kelley T, Elmer H, Corey D. Reduced Smad3 protein expression and altered transforming growth factor-beta1-mediated signaling in cystic fibrosis epithelial cells. Am J Respir Cell Mol Biol. 2001;25:732-8 pubmed..We conclude that a CF-related reduction in Smad3 protein expression selectively alters TGF- beta1-mediated signaling in CF epithelium, potentially contributing to aggressive inflammatory responses. ..
- Xiao Y, Hughes A, Ando J, Matsuda Y, Cheng J, Skinner Noble D, et al. A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins. BMC Genomics. 2004;5:56 pubmed..Further analysis of these defensins in different vertebrate lineages will shed light on the mechanisms of host defense and evolution of innate immunity. ..
- Zhou X, Tarver M, Bennett G, Oi F, Scharf M. Two hexamerin genes from the termite Reticulitermes flavipes: Sequence, expression, and proposed functions in caste regulation. Gene. 2006;376:47-58 pubmed..Second, due to their unique structural features and other observed characteristics, our findings support the hypothesis that the two hexamerins participate in the regulation of caste-differentiation by modulating JH availability. ..
- Kazanjian A, Gross E, Grimes H. The growth factor independence-1 transcription factor: new functions and new insights. Crit Rev Oncol Hematol. 2006;59:85-97 pubmed..Here we review the latest literature on Gfi1, and emphasize its role in the hematopoietic, sensory and neuroendocrine systems. ..
- Miyakoshi K, Murphy M, Yeoman R, Mitra S, Dubay C, Hennebold J. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. Biol Reprod. 2006;75:823-35 pubmed publisher..Collectively, these results suggest that the PRSS35 and PRSS23 genes have been conserved as critical ovarian proteases throughout the course of vertebrate evolution...
- Butchbach M, Edwards J, Schussler K, Burghes A. A novel method for oral delivery of drug compounds to the neonatal SMNDelta7 mouse model of spinal muscular atrophy. J Neurosci Methods. 2007;161:285-90 pubmed..This approach offers a simple and rapid means by which potential therapeutics for SMA can be identified. ..
- Fisher D, Shen S, Meredith R. MIRD dose estimate report No. 20: radiation absorbed-dose estimates for 111In- and 90Y-ibritumomab tiuxetan. J Nucl Med. 2009;50:644-52 pubmed publisher..8 in the red marrow, 0.65 in the liver, 0.077 in the intestinal wall, 0.30 in the lungs, 0.46 in the spleen, and 0.34 in the heart wall. ..
- German D, Bittong R. Digestive enzyme activities and gastrointestinal fermentation in wood-eating catfishes. J Comp Physiol B. 2009;179:1025-42 pubmed publisher..This stands in contrast to truly "xylivorous" taxa (e.g., beavers, termites), which are reliant on an endosymbiotic community of microorganisms to digest refractory polysaccharides...
- Fu X, Dai X, Ding J, Zhu B. Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions. J Mol Histol. 2009;40:189-99 pubmed publisher..The absence of PDIp expression in pancreatic adenocarcinoma may serve as an additional biomarker for pancreatic cancer. ..
- Weiss J, Xue C, Benice T, Xue L, Morris S, Raber J. Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis. Pharmacol Biochem Behav. 2012;100:566-74 pubmed publisher..We also report genetic interactions between Alk and Ltk with respect to neurogenesis and behavioral measures such as activity, anxiety levels, and retention of spatial memory. ..
- Liang J, Wang W, Sorensen D, Medina S, Ilchenko S, Kiselar J, et al. Cellular prion protein regulates its own ?-cleavage through ADAM8 in skeletal muscle. J Biol Chem. 2012;287:16510-20 pubmed publisher..Moreover, we found that overexpression of PrP(C) led to up-regulation of ADAM8, suggesting that PrP(C) may regulate its own ?-cleavage through modulating ADAM8 activity. ..
- Soofi A, Wolf K, Emont M, Qi N, Martinez Santibañez G, Grimley E, et al. The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. J Biol Chem. 2017;292:9051-9062 pubmed publisher..These findings demonstrate that shifting the TGF-? superfamily signaling with a secreted protein can alter the physiology and thermogenic properties of adipose tissue to reduce obesity even when mice are fed a high-fat diet. ..
- Lu Q, Powles R, Abdallah S, Ou D, Wang Q, Hu Y, et al. Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease. PLoS Genet. 2017;13:e1006933 pubmed publisher..Our GenoSkyline-Plus annotations are freely available at http://genocanyon.med.yale.edu/GenoSkyline. ..
- Samuel S, Tzung S, Cohen S. Hrp12, a novel heat-responsive, tissue-specific, phosphorylated protein isolated from mouse liver. Hepatology. 1997;25:1213-22 pubmed..Finally, the amount of Hrp12 protein was also found to increase after heat shock in a manner that was consistent with heat-responsive proteins. ..
- Cooper M, Bush J, Fehniger T, VanDeusen J, Waite R, Liu Y, et al. In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells. Blood. 2002;100:3633-8 pubmed..These results show conclusively that IL-15 is required for mature NK cell survival in vivo and suggest that IL-15 mediates its effect on NK cell survival by means of Bcl-2. ..
- Duan W, Ding H, Subler M, Zhu W, Zhang H, Stoner G, et al. Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice. Oncogene. 2002;21:7831-8 pubmed
- Liu S, Halbert C, Miller A. Jaagsiekte sheep retrovirus envelope efficiently pseudotypes human immunodeficiency virus type 1-based lentiviral vectors. J Virol. 2004;78:2642-7 pubmed..We created several chimeric Env proteins that, unlike the parental Env, do not transform rodent fibroblasts but are still capable of pseudotyping lentiviral and oncoretroviral vectors. ..
- Ling C, Verbny Y, Banks M, Sandor M, Fabry Z. In situ activation of antigen-specific CD8+ T cells in the presence of antigen in organotypic brain slices. J Immunol. 2008;180:8393-9 pubmed..These data suggest that brain-resident CD11c(+) cells stimulate Ag-specific naive CD8(+) T cells locally in the CNS and may contribute to immune responses in the brain. ..
- Zhang W, Zhang T, Wu Y, Jiang J. Genome-wide identification of regulatory DNA elements and protein-binding footprints using signatures of open chromatin in Arabidopsis. Plant Cell. 2012;24:2719-31 pubmed publisher..Thus, genome-wide DH site mapping will be an important tool for systematic identification of all cis-regulatory DNA elements in plants. ..
- Lado D, Browe C, Gaskin A, Borden J, MacLennan A. Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions. Gene. 1994;149:331-6 pubmed..Therefore, edg-1 may play a cell-type-specific role in differentiation and also participate in neurotransmission. ..
- Yoshitake Y, Howard T, Christian J, Hollenberg S. Misexpression of Polycomb-group proteins in Xenopus alters anterior neural development and represses neural target genes. Dev Biol. 1999;215:375-87 pubmed..These observations indicate an important role for the Polycomb-group in regulating gene expression in the developing anterior central nervous system. ..
- Klaassen C, Aleksunes L. Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev. 2010;62:1-96 pubmed publisher..Transporters are important transmembrane proteins that mediate the cellular entry and exit of a wide range of substrates throughout the body and thereby play important roles in human physiology, pharmacology, pathology, and toxicology. ..
- Mahoney C, Brewer D, Costello M, Brewer J, Bittman E. Lateralization of the central circadian pacemaker output: a test of neural control of peripheral oscillator phase. Am J Physiol Regul Integr Comp Physiol. 2010;299:R751-61 pubmed publisher..Our results indicate that neural pathways contribute to, but cannot completely account for, SCN regulation of the phase of peripheral oscillators...
- Raport C, Gosling J, Schweickart V, Gray P, Charo I. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha. J Biol Chem. 1996;271:17161-6 pubmed..CCR5 is expressed in lymphoid organs such as thymus and spleen, as well as in peripheral blood leukocytes, including macrophages and T cells, and is the first example of a human chemokine receptor that signals in response to MIP-1beta. ..
- Kalaria R, Premkumar D, Lin C, Kroon S, Bae J, Sayre L, et al. Identification and expression of the Na+/H+ exchanger in mammalian cerebrovascular and choroidal tissues: characterization by amiloride-sensitive [3H]MIA binding and RT-PCR analysis. Brain Res Mol Brain Res. 1998;58:178-87 pubmed..Our study suggests that mammalian cerebrovascular and choroidal tissues contain high amounts of the ubiquitous amiloride-sensitive [3H]MIA binding proteins consistent with the expression of NHE type 1 mRNA. ..
- Frydman H, Li J, Robson D, Wieschaus E. Somatic stem cell niche tropism in Wolbachia. Nature. 2006;441:509-12 pubmed..This is, to our knowledge, the first report of an intracellular parasite displaying tropism for a stem cell niche. ..
- Caia G, Efimova O, Velayutham M, El Mahdy M, Abdelghany T, Kesselring E, et al. Organ specific mapping of in vivo redox state in control and cigarette smoke-exposed mice using EPR/NMR co-imaging. J Magn Reson. 2012;216:21-7 pubmed publisher..Thus, in vivo EPR/NMR co-imaging enables in vivo organ specific mapping of free radical metabolism and redox stress and the alterations that occur in the pathogenesis of disease. ..
- Yao J, Buschman L, Oppert B, Khajuria C, Zhu K. Characterization of cDNAs encoding serine proteases and their transcriptional responses to Cry1Ab protoxin in the gut of Ostrinia nubilalis larvae. PLoS ONE. 2012;7:e44090 pubmed publisher..nubilalis larvae and demonstrate differential expression of protease genes that may be related to Cry1Ab intoxication and/or resistance. ..
- Guo J, Yu J, Grass D, de Beer F, Kindy M. Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis. J Neurosci. 2002;22:5900-9 pubmed..These studies indicate that inflammation plays an important role in the process of amyloid deposition, and inhibition of inflammatory cascades may attenuate amyloidogenic processes, such as Alzheimer's disease. ..
- Kumar D, Kumar P, James P. Methylation-dependent and independent regulatory regions in the Na,K-ATPase alpha4 (Atp1a4) gene may impact its testis-specific expression. Gene. 2016;575:339-52 pubmed publisher..In all, our data suggests that both the promoter and the intragenic CGI could combine to provide multiple modes of regulation for optimizing the Atp1a4 expression level in a cell type-specific manner. ..
- Gao Y, Nelson D, Banh T, Yen M, Yen C. Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice. J Lipid Res. 2013;54:1644-52 pubmed publisher..These data indicate that MGAT2 in the intestine plays an indispensable role in enhancing metabolic efficiency but also raise the possibility that MGAT2 in other tissues may contribute to the regulation of energy metabolism. ..
- Karunakaran D, Congdon S, Guerrette T, Banday A, Lemoine C, Chhaya N, et al. The expression analysis of Sfrs10 and Celf4 during mouse retinal development. Gene Expr Patterns. 2013;13:425-36 pubmed publisher..In all, our data suggests an important role for AS and mRNA localization/translation in retinal neuron differentiation. ..
- Matsuo M, Ensor C, Tai H. Cloning and expression of the cDNA for mouse NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim Biophys Acta. 1996;1309:21-4 pubmed..The authenticity of the mouse cDNA was confirmed by expression of an active 15-PGDH in Escherichia coli. Northern blot analysis demonstrated that 15-PGDH mRNA is expressed primarily in lung, intestine, stomach and liver. ..
- Fan Y, Newman T, Linardopoulou E, Trask B. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. Genome Res. 2002;12:1663-72 pubmed..This study illustrates that the duplication and rearrangement of subtelomeric and pericentromeric regions have functional relevance to human biology; these processes can change gene dosage and/or generate genes with new functions. ..
- Geusz M, Blakely K, Hiler D, Jamasbi R. Elevated mPer1 gene expression in tumor stroma imaged through bioluminescence. Int J Cancer. 2010;126:620-30 pubmed publisher..These results suggest that mPer1 activity may play a localized role in the interactions between cancer and stromal cells. The effects might be exploited clinically by targeting the circadian clock genes of stromal cells. ..
- Snyder A, Dulin Smith A, Houston R, Durban A, Brisbin B, Oostra T, et al. Expression pattern of id proteins in medulloblastoma. Pathol Oncol Res. 2013;19:437-46 pubmed publisher..This study shows that Id1 expression in endothelial cells may contribute to angiogenic processes and that increased expression of Id2 and Id3 in medulloblastoma is potentially involved in tumor cell proliferation and survival. ..
- Yan C, Zhao A, Bentley J, Beavo J. The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner. J Biol Chem. 1996;271:25699-706 pubmed..In summary, these findings suggest that the PDE1C gene undergoes tissue-specific alternative splicing that generates structurally and functionally diverse gene products. ..
- Renaud H, Cui J, Khan M, Klaassen C. Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. Toxicol Sci. 2011;124:261-77 pubmed publisher..In conclusion, this study provides novel data on the tissue distribution and gender-divergent expression of 78 functional mouse Cyp isoforms. ..
- Scerpella T, Bernardoni B, Wang S, Rathouz P, Li Q, Dowthwaite J. Site-specific, adult bone benefits attributed to loading during youth: A preliminary longitudinal analysis. Bone. 2016;85:148-59 pubmed publisher..Additional longitudinal observation is necessary to determine whether residual loading benefits enhance lifelong skeletal strength. ..
- Gaggar A, Shayakhmetov D, Lieber A. CD46 is a cellular receptor for group B adenoviruses. Nat Med. 2003;9:1408-12 pubmed
- Vanderford N. Regulation of ?-cell-specific and glucose-dependent MafA expression. Islets. 2011;3:35-7 pubmed
- Kron M, Howell C, Adams I, Ransbottom M, Christian D, Ogier M, et al. Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment. J Neurosci. 2012;32:13860-72 pubmed publisher..In light of recent findings that the default mode network is hypoactive in autism, our data raise the possibility that hypofunction within this meta-circuit is a shared feature of RTT and other ASDs and is reversible. ..
- Zhang J, Nicholson B. Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA. J Cell Biol. 1989;109:3391-401 pubmed..This raises the interesting prospect of having differential modes of regulating intercellular channels within a given tissue and, at least in the case of liver, a given cell. ..
- Tsika R, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, et al. TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. J Biol Chem. 2010;285:13721-35 pubmed publisher..These data provide the first in vivo evidence that increased TEAD-1 can induce characteristics of cardiac remodeling associated with cardiomyopathy and heart failure. ..
- LeMaster A, Krimm R, Davis B, Noel T, Forbes M, Johnson J, et al. Overexpression of brain-derived neurotrophic factor enhances sensory innervation and selectively increases neuron number. J Neurosci. 1999;19:5919-31 pubmed..These data indicate that skin-derived BDNF does not enhance survival of cutaneous sensory neurons, although it does promote neurite innervation of specific sites and sensory end organs of the skin. ..
- Seiffert M, Custodio J, Wolf I, Harkey M, Liu Y, Blattman J, et al. Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent. Mol Cell Biol. 2003;23:2415-24 pubmed..Together, these data demonstrate that loss of Gab3 does not result in detectable defects in normal mouse development, hematopoiesis, or immune system function. ..
- Klonowski K, Marzo A, Williams K, Lee S, Pham Q, Lefrancois L. CD8 T cell recall responses are regulated by the tissue tropism of the memory cell and pathogen. J Immunol. 2006;177:6738-46 pubmed..Our findings indicated that characteristics of the infectious agent and the migratory preferences of memory cells dictated the secondary lymphoid tissue requirement for the recall response to infection. ..
- Conner J, Beisswenger P, Szwergold B. The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals. Biochem Biophys Res Commun. 2004;323:932-6 pubmed..These data suggest that FN3K and FN3KRP act as protein repair enzymes and are expressed constitutively in human cells independently of some of the variables altered in the diabetic state. ..
- Kinsey G, Cummings B, Beckett C, Saavedra G, Zhang W, McHowat J, et al. Identification and distribution of endoplasmic reticulum iPLA2. Biochem Biophys Res Commun. 2005;327:287-93 pubmed publisher..These results demonstrate the expression of ER-iPLA2gamma (group VIB) across species and tissues, and suggest that iPLA2gamma may play critical roles in oxidant-induced cell injury...
- Hu S, Tamada K, Ni J, Vincenz C, Chen L. Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Genomics. 1999;62:103-7 pubmed
- Leonard A, Kelder B, Bobik E, Chuang L, Lewis C, Kopchick J, et al. Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids. 2002;37:733-40 pubmed..This report demonstrates the isolation and identification of two mammalian genes that encode very long chain PUFA specific elongation enzymes in the Sprecher pathway for DHA synthesis. ..
- Farfan E, Huston T, Bolch W, Vernetson W, Bolch W. Influences of parameter uncertainties within the ICRP-66 respiratory tract model: regional tissue doses for 239PuO2 and 238UO2/238U3O8. Health Phys. 2003;84:436-50 pubmed
- Yan C, Lian X, Li Y, Dai Y, White A, Qin Y, et al. Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice. Am J Pathol. 2006;169:916-26 pubmed..These studies strongly support that neutral lipid metabolism in macrophages contributes to organ inflammation and pathogenesis. ..
- Wolfrum U, Salisbury J. Expression of centrin isoforms in the mammalian retina. Exp Cell Res. 1998;242:10-7 pubmed..These observations suggest centrin 2 message may be universally expressed while centrin 1 message may be restricted to retina and testis which contain cells that have differentiated cilia or flagella, or their modifications. ..
- Hurskainen T, Hirohata S, Seldin M, Apte S. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999;274:25555-63 pubmed..Individual ADAM-TS members differ in the number of COOH-terminal TS modules, and some have unique COOH-terminal domains. The ADAM-TS genes are dispersed in human and mouse genomes. ..
- Ratajczak M, Zuba Surma E, Machalinski B, Ratajczak J, Kucia M. Very small embryonic-like (VSEL) stem cells: purification from adult organs, characterization, and biological significance. Stem Cell Rev. 2008;4:89-99 pubmed publisher..We named these primitive cells very small embryonic-like (VSEL) SCs. Our data indicate that VSELs may differentiate into cells from all three germ layers. ..
- Thomas A, Hart S, Kong B, Fang J, Zhong X, Guo G. Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine. Hepatology. 2010;51:1410-9 pubmed publisher..In addition, FXR may be involved in regulating broader biological pathways in maintaining hepatic and intestinal homeostasis. ..
- Spillman M, Manning N, Dye W, Sartorius C, Post M, Harrell J, et al. Tissue-specific pathways for estrogen regulation of ovarian cancer growth and metastasis. Cancer Res. 2010;70:8927-36 pubmed publisher..Because breast cancer selective ER modulators (SERM) are therapeutically ineffective in EOC, we suggest that our EOC-specific E2-regulated genes can assist pharmacologic discovery of ovarian-targeted SERM. ..
- Nanda V, Miano J. Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells. J Biol Chem. 2012;287:2459-67 pubmed publisher..Such activity is abolished upon mutation of both CArG boxes. Collectively, these data demonstrate that Lmod1 is a new SMC-restricted SRF/MYOCD target gene. ..
- Nace J, Tassava R. Examination of fibronectin distribution and its sources in the regenerating newt limb by immunocytochemistry and in situ hybridization. Dev Dyn. 1995;202:153-64 pubmed..The expression pattern of FN throughout regeneration suggests that this glycoprotein has roles in wound epithelial and mesenchymal cell migration and mesenchymal cell proliferation and differentiation. ..
- Clegg C, Haugen H, Boring L. Promoter sequences in the RI beta subunit gene of cAMP-dependent protein kinase required for transgene expression in mouse brain. J Biol Chem. 1996;271:1638-44 pubmed..These results have identified specific regions of the RI beta promoter that are required for the expression of this signal transduction protein in mouse neurons. ..
- Turker M, Gage B, Rose J, Ponomareva O, Tischfield J, Stambrook P, et al. Solid tissues removed from ATM homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations. Cancer Res. 1999;59:4781-3 pubmed..We report here the lack of a mutator phenotype for inactivating autosomal mutations in solid tissues of the Atm-deficient mice. ..
- Qian J, Yehia G, Molina C, Fernandes A, Donnelly R, Anjaria D, et al. Cloning of human preprotachykinin-I promoter and the role of cyclic adenosine 5'-monophosphate response elements in its expression by IL-1 and stem cell factor. J Immunol. 2001;166:2553-61 pubmed..As PPT-I is implicated in hemopoietic regulation, immune responses, breast cancer, and other neural functions, these studies add to the basic biology of these processes and could provide targets for drug development. ..
- Fritz D, Jiang S, Xu J, Rogers M. A polymorphism in a conserved posttranscriptional regulatory motif alters bone morphogenetic protein 2 (BMP2) RNA:protein interactions. Mol Endocrinol. 2006;20:1574-86 pubmed..The consequent alterations in BMP2 protein levels may influence the development or physiology of bone or other BMP2-influenced tissues. ..