Experts and Doctors on oncogene proteins in Israel
Topic: oncogene proteins
Lev N, Barhum Y, Ben Zur T, Melamed E, Steiner I, Offen D. Knocking out DJ-1 attenuates astrocytes neuroprotection against 6-hydroxydopamine toxicity. J Mol Neurosci. 2013;50:542-50 pubmed publisher
..These experiments demonstrated that lack of DJ-1 impairs astrocyte-mediated neuroprotection. ..
Margalit O, Eisenbach L, Amariglio N, Kaminski N, Harmelin A, Pfeffer R, et al
. Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines. Br J Cancer. 2003;89:314-9 pubmed
..Further research should address the precise role of these genes in the metastasising process to the lungs and test if they could be used as targets for future therapies...
Rainis L, Toki T, Pimanda J, Rosenthal E, Machol K, Strehl S, et al
. The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res. 2005;65:7596-602 pubmed
Lev N, Ickowicz D, Barhum Y, Lev S, Melamed E, Offen D. DJ-1 protects against dopamine toxicity. J Neural Transm (Vienna). 2009;116:151-60 pubmed publisher
..This mechanism elucidates how mutations in DJ-1 prompt PD and imply that modulation of DJ-1 may serve as a novel neuroprotective modality. ..
Lev N, Ickowicz D, Barhum Y, Blondheim N, Melamed E, Offen D. Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosis. Antioxid Redox Signal. 2006;8:1987-95 pubmed
..In view of the accumulating evidence on the central role of oxidative stress in MS, and the importance of DJ-1 in oxidative stress management by the CNS, we believe that DJ-1 will be found to have a central role in MS. ..
Lev N, Roncevic D, Roncevich D, Ickowicz D, Melamed E, Offen D. Role of DJ-1 in Parkinson's disease. J Mol Neurosci. 2006;29:215-25 pubmed
..This article reviews the current knowledge on DJ-1, focusing on its importance in the pathogenesis of PD. ..
Lev N, Ickowicz D, Melamed E, Offen D. Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection. Neurotoxicology. 2008;29:397-405 pubmed publisher
..These results may imply that DJ-1 plays an important role in the neuronal defense mechanism against oxidative insults. ..
Jeison M, Ash S, Halevy Berko G, Mardoukh J, Luria D, Avigad S, et al
. 2p24 Gain region harboring MYCN gene compared with MYCN amplified and nonamplified neuroblastoma: biological and clinical characteristics. Am J Pathol. 2010;176:2616-25 pubmed publisher
Haider N, Dusseault J, Rudich A, Larose L. Nck2, an unexpected regulator of adipogenesis. Adipocyte. 2017;6:154-160 pubmed publisher
..We propose that Nck2 should be further investigated as a regulator of the reliance of white adipose tissue on hyperplasia versus hypertrophy during adipose tissue expansion, and hence, as a potential novel molecular target in obesity. ..