Experts and Doctors on oleic acid in Taiwan
Topic: oleic acid
Kuo T, Wu C, Hsu C, Lo W, Chiang S, Lin S, et al
. Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles. Biomaterials. 2009;30:3002-8 pubmed publisher
..The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC. ..
Hsu S, Huang C. Reduced fat mass in rats fed a high oleic acid-rich safflower oil diet is associated with changes in expression of hepatic PPARalpha and adipose SREBP-1c-regulated genes. J Nutr. 2006;136:1779-85 pubmed
Fang K, Lee A, Su M, Lin C, Chien C, Wu M. Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. Cardiovasc Res. 2008;78:533-45 pubmed publisher
..AA and FFAs, which accumulate in the myocardium during post-I/R, may therefore act as naturally occurring endogenous ionophores and contribute to the myocyte death seen during post-I/R. ..
Chan S, Chu P, Kao C, Cheng Y, Hung C, Tsai K. Oleic acid activates MMPs up-regulation through SIRT1/PPAR-? inhibition: a probable linkage between obesity and coronary arterial disease. J Biochem. 2016;160:217-225 pubmed
..Overall, we suggested that OA enhances MMPs activation through SIRT1 down-regulation. Therefore, our findings might provide a novel route for developing new therapeutic treatments for FFAs-related CADs. ..
Chen J, Greenberg A, Wang S. Oleic acid-induced PKC isozyme translocation in RAW 264.7 macrophages. J Cell Biochem. 2002;86:784-91 pubmed
..Furthermore, downregulation of PKC delta was confirmed by immunoblotting. These results demonstrate possible involvement of specific PKC isozymes in the early phase of lipid accumulation, possibly during the uptake of OA. ..
Yeh D, Lin H, Feng N, Chen C, Wang D, Wang N. Matrix metalloprotease expressions in both reperfusion lung injury and oleic acid lung injury models and the protective effects of ilomastat. Transplant Proc. 2009;41:1508-11 pubmed publisher
..001). Ilomastat significantly attenuated the extent of lung inflammation and injury induced by both I/R and OA. MMP may play a critical role in the lung injury induced by I/R and OA infusion. ..
Hsu K, Fan H, Chen Y, Huang Y, Chen C, Wu J, et al
. Protein kinase C-Fyn kinase cascade mediates the oleic acid-induced disassembly of neonatal rat cardiomyocyte adherens junctions. Int J Biochem Cell Biol. 2009;41:1536-46 pubmed publisher
..Therefore, inhibitors of PKC-alpha/-epsilon and Src family kinase are potential candidates as cardioprotection agents against OA-induced heart injury during ischemia-reperfusion. ..