Experts and Doctors on octanoic acids in United States


Locale: United States
Topic: octanoic acids

Top Publications

  1. Zhao Y, Tan Y, Strynar M, Perez G, Haslam S, Yang C. Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice. Reprod Toxicol. 2012;33:563-576 pubmed publisher
    ..These results indicate that PFOA effects on ovaries mediate its inhibition of mammary gland development in Balb/c and C57Bl/6 mice and that PPARα expression is a contributing factor. ..
  2. Fair P, Houde M, Hulsey T, Bossart G, Adams J, Balthis L, et al. Assessment of perfluorinated compounds (PFCs) in plasma of bottlenose dolphins from two southeast US estuarine areas: relationship with age, sex and geographic locations. Mar Pollut Bull. 2012;64:66-74 pubmed publisher
    ..These observations suggest PFC accumulation in these two dolphin populations are influenced by site-specific exposures with significantly higher levels in CHS dolphins. ..
  3. Kim B, Akoh C. Chemical and physical properties of butterfat-vegetable oil blend spread prepared with enzymatically transesterified canola oil and caprylic acid. J Agric Food Chem. 2005;53:4954-61 pubmed
    ..Rheological analysis showed that butterfat-SL blend spread lost its elastic behavior at 5 degrees C, a lower temperature than pure butter. ..
  4. Jiang Q, Lust R, Strynar M, Dagnino S, DeWitt J. Perflurooctanoic acid induces developmental cardiotoxicity in chicken embryos and hatchlings. Toxicology. 2012;293:97-106 pubmed publisher
    ..Additional studies will investigate mechanisms of PFOA-induced developmental cardiotoxicity. ..
  5. Klaunig J, Hocevar B, Kamendulis L. Mode of Action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and Human Relevance. Reprod Toxicol. 2012;33:410-418 pubmed publisher
    ..This review will address the rodent (rat) cancer data and cancer Mode of Action of PFOA for tumors of the liver, testes and pancreas. ..
  6. Loccisano A, Campbell J, Butenhoff J, Andersen M, Clewell H. Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model. Reprod Toxicol. 2012;33:468-490 pubmed publisher
  7. Loccisano A, Campbell J, Butenhoff J, Andersen M, Clewell H. Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model. Reprod Toxicol. 2012;33:452-467 pubmed publisher
  8. Rane S, Anderson B. Molecular dynamics simulations of functional group effects on solvation thermodynamics of model solutes in decane and tricaprylin. Mol Pharm. 2008;5:1023-36 pubmed publisher
    ..The dissolved water was found to exist approximately 50% as monomers and 50% as self-associated species. Substantial hydrogen-bonding of benzamide with ester carbonyl oxygen atoms was observed. ..
  9. Taber D, DeMatteo P. A piperidine chiron for the Veratrum alkaloids. J Org Chem. 2012;77:4235-41 pubmed publisher
    ..A Veratrum piperidine chiron was prepared over 11 steps (7.9% yield) from (-)-citronellal. Three methods for the installation of the propargylic side chain onto a cyclic enamide are presented. ..

More Information


  1. Biegel L, Hurtt M, Frame S, O Connor J, Cook J. Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats. Toxicol Sci. 2001;60:44-55 pubmed
    ..This study suggests that estradiol may play a role in enhancement of Leydig cell tumors in the rat, and that peroxisome proliferators may induce tumors via a non-LH type mechanism. ..
  2. Kim B, Akoh C. Characteristics of structured lipid prepared by lipase-catalyzed acidolysis of roasted sesame oil and caprylic acid in a bench-scale continuous packed bed reactor. J Agric Food Chem. 2006;54:5132-41 pubmed
    ..These results indicate that the characteristics of SL are different from those of original sesame oil in several aspects except for the contents of tocopherols and phytosterols. ..
  3. Berthiaume J, Wallace K. Perfluorooctanoate, perflourooctanesulfonate, and N-ethyl perfluorooctanesulfonamido ethanol; peroxisome proliferation and mitochondrial biogenesis. Toxicol Lett. 2002;129:23-32 pubmed
    ..These data demonstrate that acute administration of PFOS or PFOA causes hepatic peroxisome proliferation in rats. However, stimulation of mt biogenesis is not a characteristic response of all peroxisome proliferators. ..
  4. Kim B, Akoh C. Modeling of lipase-catalyzed acidolysis of sesame oil and caprylic Acid by response surface methodology: optimization of reaction conditions by considering both acyl incorporation and migration. J Agric Food Chem. 2005;53:8033-7 pubmed
    ..The results showed that over the range of ca. 55 mol % of Y1, Y3 started to decrease, and Y2 increased rapidly, suggesting that Y1 should be kept below ca. 55 mol % to prevent decrease in quality and yield of targeted SLs. ..
  5. Kadiyala C, Tomechko S, Miyagi M. Perfluorooctanoic acid for shotgun proteomics. PLoS ONE. 2010;5:e15332 pubmed publisher
    ..Thus, this single-tube shotgun proteomics method overcomes the major drawbacks of surfactant use in proteomic experiments. ..
  6. Solís de los Santos F, Hume M, Venkitanarayanan K, Donoghue A, Hanning I, Slavik M, et al. Caprylic Acid reduces enteric campylobacter colonization in market-aged broiler chickens but does not appear to alter cecal microbial populations. J Food Prot. 2010;73:251-7 pubmed
    ..The results of this study indicate that caprylic acid's ability to reduce Campylobacter does not appear to be due to changes in cecal microflora. ..
  7. Washington J, Ellington J, Jenkins T, Evans J, Yoo H, Hafner S. Degradability of an acrylate-linked, fluorotelomer polymer in soil. Environ Sci Technol. 2009;43:6617-23 pubmed
    ..These results suggest that fluoratelomer-polymer degradation is a significant source of PFOA and other fluorinated compounds to the environment. ..
  8. Spliethoff H, Tao L, Shaver S, Aldous K, Pass K, Kannan K, et al. Use of newborn screening program blood spots for exposure assessment: declining levels of perluorinated compounds in New York State infants. Environ Sci Technol. 2008;42:5361-7 pubmed
    ..Our results suggest sharp decreases in perinatal exposure of NYS infants to PFOS, PFOSA, PFHxS, and PFOA and demonstrate, for the first time, the utility of NSP blood spots for assessment of temporal trends in exposure. ..
  9. Rane S, Cao Y, Anderson B. Quantitative solubility relationships and the effect of water uptake in triglyceride/monoglyceride microemulsions. Pharm Res. 2008;25:1158-74 pubmed
    ..This study provides a potential universal framework for predicting relative drug solubility in mixtures containing fully saturated triglycerides and monoglycerides. ..
  10. Russell M, Berti W, Szostek B, Buck R. Investigation of the biodegradation potential of a fluoroacrylate polymer product in aerobic soils. Environ Sci Technol. 2008;42:800-7 pubmed
  11. Tao L, Kannan K, Aldous K, Mauer M, Eadon G. Biomonitoring of perfluorochemicals in plasma of New York State personnel responding to the World Trade Center disaster. Environ Sci Technol. 2008;42:3472-8 pubmed
    ..In doing so, it may be possible to identify biological markers of WTC exposure and to improve our understanding of the health impacts of these compounds. ..
  12. Yang C, Glover K, Han X. Organic anion transporting polypeptide (Oatp) 1a1-mediated perfluorooctanoate transport and evidence for a renal reabsorption mechanism of Oatp1a1 in renal elimination of perfluorocarboxylates in rats. Toxicol Lett. 2009;190:163-71 pubmed publisher
    ..Due to the sex-dependent expression of Oatp1a1 in rat kidney, Oatp1a1-mediated tubular reabsorption is suggested to be the mechanism for the sex-dependent renal elimination of PFO in rats. ..
  13. Yang C, Glover K, Han X. Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates. Toxicol Sci. 2010;117:294-302 pubmed publisher
    ..Our results suggest that OAT4 and URAT1 are key transporters in renal reabsorption of PFCs in humans and, as a result, may contribute significantly to the long half-life of PFO in humans. ..
  14. Loccisano A, Campbell J, Andersen M, Clewell H. Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model. Regul Toxicol Pharmacol. 2011;59:157-75 pubmed publisher
    ..It is envisioned that our PBPK model will be useful in supporting human health risk assessments for PFOA and PFOS by aiding in understanding of human pharmacokinetics. ..
  15. Tilton S, Orner G, Benninghoff A, Carpenter H, Hendricks J, Pereira C, et al. Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout. Environ Health Perspect. 2008;116:1047-55 pubmed publisher
    ..These data suggest that the tumor-promoting activities of PFOA in trout are due to novel mechanisms involving estrogenic signaling and are independent of peroxisome proliferation. ..
  16. Han X, Hinderliter P, Snow T, Jepson G. Binding of perfluorooctanoic acid to rat liver-form and kidney-form alpha2u-globulins. Drug Chem Toxicol. 2004;27:341-60 pubmed
  17. Metcalf J, Donoghue A, Venkitanarayanan K, Reyes Herrera I, Aguiar V, Blore P, et al. Water administration of the medium-chain fatty acid caprylic acid produced variable efficacy against enteric Campylobacter colonization in broilers. Poult Sci. 2011;90:494-7 pubmed publisher
    ..In trial 2, no treatment reduced Campylobacter counts compared with the positive control. Unlike the efficacy of caprylic acid in feed, treatment with caprylic acid in water had an inconsistent effect on intestinal Campylobacter counts. ..
  18. Yang Z, Liu Y, Mao L, Zhang J, Zou Y. Dimerization of human XPA and formation of XPA2-RPA protein complex. Biochemistry. 2002;41:13012-20 pubmed
    ..Taken together, our data suggest that the dimerization of XPA may play an important role in the DNA damage recognition of nucleotide excision repair. ..
  19. Han X, Nabb D, Russell M, Kennedy G, Rickard R. Renal elimination of perfluorocarboxylates (PFCAs). Chem Res Toxicol. 2012;25:35-46 pubmed publisher
  20. Huang C, Alimova Y, Myers T, Ebersole J. Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. Arch Oral Biol. 2011;56:650-4 pubmed publisher
    ..Further studies on these functions are required to better understand the nature of these potential microbial interactions in the biofilms. ..
  21. Ballow M, Berger M, Bonilla F, Buckley R, Cunningham Rundles C, Fireman P, et al. Pharmacokinetics and tolerability of a new intravenous immunoglobulin preparation, IGIV-C, 10% (Gamunex, 10%). Vox Sang. 2003;84:202-10 pubmed
  22. Kennedy G, Butenhoff J, Olsen G, O Connor J, Seacat A, Perkins R, et al. The toxicology of perfluorooctanoate. Crit Rev Toxicol. 2004;34:351-84 pubmed
    ..Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects. ..
  23. DeWitt J, Peden Adams M, Keller J, Germolec D. Immunotoxicity of perfluorinated compounds: recent developments. Toxicol Pathol. 2012;40:300-11 pubmed publisher
    ..This review contains brief descriptions of current and recently published work exploring immunomodulation by PFOA, PFOS, and other PFCs in rodent models, alternative laboratory models, and wildlife...
  24. Afitlhile M, Fukushige H, Nishimura M, Hildebrand D. A defect in glyoxysomal fatty acid beta-oxidation reduces jasmonic acid accumulation in Arabidopsis. Plant Physiol Biochem. 2005;43:603-9 pubmed
    ..Thus, reduced levels of JA in the wounded tissues of the mutant were attributed to the defect in a thiolase protein...
  25. Gutierrez J, Solenberg P, Perkins D, Willency J, Knierman M, Jin Z, et al. Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A. 2008;105:6320-5 pubmed publisher
    ..The occurrence of ghrelin and GOAT in stomach and pancreas tissues demonstrates the relevance of GOAT in the acylation of ghrelin and further implicates acylated ghrelin in pancreatic function. ..
  26. Walters M, Wallace K. Urea cycle gene expression is suppressed by PFOA treatment in rats. Toxicol Lett. 2010;197:46-50 pubmed publisher
    ..Our findings provide further evidence of the effect of PFOA on intermediary metabolism in rodents and add valuable information in assessing the potential risks of PFOA exposure. ..
  27. Loveless S, Hoban D, Sykes G, Frame S, Everds N. Evaluation of the immune system in rats and mice administered linear ammonium perfluorooctanoate. Toxicol Sci. 2008;105:86-96 pubmed publisher
    ..In summary, no immune-related changes occurred in rats, even at doses causing systemic toxicity. In mice, immune-related changes occurred only at doses causing significant and profound systemic toxicity and stress...
  28. Cheng X, Klaassen C. Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors. Toxicol Sci. 2008;106:29-36 pubmed publisher
    ..In conclusion, PFCAs increased Cyp2B10 and 4A14 expression by activating PPAR-alpha and CAR nuclear receptors, respectively. PPAR-alpha is activated at much lower doses of PFDA than CAR. ..
  29. DeWitt J, SHNYRA A, Badr M, Loveless S, Hoban D, Frame S, et al. Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha. Crit Rev Toxicol. 2009;39:76-94 pubmed
    ..This multiauthored review contains brief descriptions of current and recently published work exploring immunomodulation by PFOA and PFOS, as well as a short overview of other PPARalpha ligands of therapeutic and environmental interest...
  30. Cheng X, Klaassen C. Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers. Toxicol Sci. 2008;106:37-45 pubmed publisher
    ..In conclusion, PFOA and PFDA decrease mouse liver uptake transporters primarily via activation of PPAR-alpha. ..
  31. Bjork J, Butenhoff J, Wallace K. Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes. Toxicology. 2011;288:8-17 pubmed publisher
  32. Raymer J, Michael L, Studabaker W, Olsen G, Sloan C, Wilcosky T, et al. Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements. Reprod Toxicol. 2012;33:419-427 pubmed publisher
    ..Luteinizing hormone was positively correlated with plasma PFOA and PFOS, but not semen PFOS. Important methodological concerns included the lack of multiple hormonal measurements necessary to address circadian rhythms. ..
  33. Han X, Yang C, Snajdr S, Nabb D, Mingoia R. Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats. Toxicol Lett. 2008;181:81-6 pubmed publisher
    ..9 +/- 25.1 and 29.3 +/- 19.2 microM in male and female rat hepatocytes, respectively. When serum albumin was added to the incubations, PFO hepatic uptake rates were reduced, but were proportional to the unbound fractions of PFO. ..
  34. Abbott B, Wood C, Watkins A, Tatum Gibbs K, Das K, Lau C. Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues. Reprod Toxicol. 2012;33:491-505 pubmed publisher
    ..The metabolic disruption produced by PFOA may contribute to poor postnatal survival and persistent weight deficits of CD-1 mouse neonates. ..
  35. Hines E, White S, Stanko J, Gibbs Flournoy E, Lau C, Fenton S. Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life. Mol Cell Endocrinol. 2009;304:97-105 pubmed publisher
    ..01mg PFOA/kg BW. The mode of action of these effects and its relevance to human health remain to be explored. ..