Genomes and Genes
Experts and Doctors on nuclear proteins in Germany
Topic: nuclear proteins
Publications488 found, 100 shown here
- Dieterle M, Zhou Y, Schafer E, Funk M, Kretsch T. EID1, an F-box protein involved in phytochrome A-specific light signaling. Genes Dev. 2001;15:939-44 pubmed..EID1 most probably acts by targeting activated components of the phyA signaling pathway to ubiquitin-dependent proteolysis. ..
- Fribourg S, Conti E. Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15. EMBO Rep. 2003;4:699-703 pubmed..In addition, Mtr2 presents a long internal loop, which contains residues that affect the export of the large ribosomal subunit. ..
- Ott M, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U, et al. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med. 2006;12:401-9 pubmed
- Jennewein C, Kuhn A, Schmidt M, Meilladec Jullig V, von Knethen A, Gonzalez F, et al. Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines. J Immunol. 2008;181:5646-52 pubmed..This contributes to an antiinflammatory phenotype shift in macrophages responding to AC by lowering proinflammatory cytokine production. ..
- Schulz I, Baumann O, Samereier M, Zoglmeier C, Gräf R. Dictyostelium Sun1 is a dynamic membrane protein of both nuclear membranes and required for centrosomal association with clustered centromeres. Eur J Cell Biol. 2009;88:621-38 pubmed publisher..FRAP analysis revealed at least two populations of Sun1, with an immobile fraction associated with the centrosome, and a mobile fraction in the nuclear envelope. ..
- Wethkamp N, Klempnauer K. Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta. J Biol Chem. 2009;284:28783-94 pubmed publisher..Overall, our data identify Daxx as a new negative regulator of C/EBPbeta and provide first clues for a link between abrogation of Daxx-C/EBPbeta complex formation and APL remission. ..
- Netz D, Stümpfig M, Dore C, Muhlenhoff U, Pierik A, Lill R. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol. 2010;6:758-65 pubmed publisher..The pathway is conserved in eukaryotes, as human Ndor1-Ciapin1 proteins can functionally replace yeast Tah18-Dre2. ..
- Finkbeiner E, Haindl M, Muller S. The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex. EMBO J. 2011;30:1067-78 pubmed publisher..These findings contribute to the basic understanding of mammalian ribosome biogenesis and shed new light on the role of SUMO in this process. ..
- Schramm A, Schowe B, Fielitz K, Heilmann M, Martin M, Marschall T, et al. Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome. Br J Cancer. 2012;107:1409-17 pubmed publisher..However, exon-level analyses provide added knowledge by identifying alternative transcript use, which should deepen the understanding of neuroblastoma biology. ..
- Peifer C, Sharma S, Watzinger P, Lamberth S, Kötter P, Entian K. Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA. Nucleic Acids Res. 2013;41:1151-63 pubmed publisher..This highlights the dual functionality of Rrp8 in the biogenesis of both subunits. ..
- Kool M, Jones D, Jäger N, Northcott P, Pugh T, Hovestadt V, et al. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell. 2014;25:393-405 pubmed publisher..Functional assays in different SHH-MB xenograft models demonstrated that SHH-MBs harboring a PTCH1 mutation were responsive to SMO inhibition, whereas tumors harboring an SUFU mutation or MYCN amplification were primarily resistant. ..
- Duffy D, Krstic A, Halasz M, Schwarzl T, Fey D, Iljin K, et al. Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma. Oncotarget. 2015;6:43182-201 pubmed publisher..Importantly, this work describes a systems-level approach to systematically uncovering network based vulnerabilities and therapeutic targets for multifactorial diseases by integrating disparate omic data types. ..
- Bauer A, Kölling R. Characterization of the SAC3 gene of Saccharomyces cerevisiae. Yeast. 1996;12:965-75 pubmed..In the act1-1 mutant, however, upon shift to non-permissive temperature, newly synthesized cell wall material, instead of being directed towards the bud, was deposited at discrete spots in the mother cell. ..
- Jelkmann W, Pagel H, Hellwig T, Fandrey J. Effects of antioxidant vitamins on renal and hepatic erythropoietin production. Kidney Int. 1997;51:497-501 pubmed..Preliminary evidence suggests that this effect of vitamin A involves increased mRNA levels of hypoxia-inducible factor 1 alpha (HIF-1 alpha). ..
- Grandi P, Dang T, Pane N, Shevchenko A, Mann M, Forbes D, et al. Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly. Mol Biol Cell. 1997;8:2017-38 pubmed
- Klockgether T, Evert B. Genes involved in hereditary ataxias. Trends Neurosci. 1998;21:413-8 pubmed..In another group of dominant disorders, episodic ataxia type I and type 2 (EA-I, EA-2) and SCA6, the mutations affect genes that code for ion channels. ..
- Hoch M, Jackle H. Krüppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of Drosophila. EMBO J. 1998;17:5766-75 pubmed
- Wilda M, Demuth I, Concannon P, Sperling K, Hameister H. Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development. Hum Mol Genet. 2000;9:1739-44 pubmed..These expression patterns suggest that in addition to the role of the Nbs1 gene product as part of a DNA DSB repair complex, the Nbs1 gene product may serve further functions during development. ..
- Hildebrand D, Tiefenbach J, Heinzel T, Grez M, Maurer A. Multiple regions of ETO cooperate in transcriptional repression. J Biol Chem. 2001;276:9889-95 pubmed..Thus, ETO has a modular structure, and the interaction between the individual elements is essential for the formation of a stable repressor complex and efficient transcriptional repression. ..
- Strasser K, Hurt E. Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature. 2001;413:648-52 pubmed..Sub2p may then be displaced from Yra1p by the binding of Mex67p/Mtr2p, which participates in the export of mRNA through the nuclear pores. ..
- Belting H, Hauptmann G, Meyer D, Abdelilah Seyfried S, Chitnis A, Eschbach C, et al. spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer. Development. 2001;128:4165-76 pubmed..Thus, expression of pou2 does not depend on fgf8 and pax2.1. Our data suggest that pou2 is required for the establishment of the normal expression domains of wnt1 and pax2.1 in the MHB primordium...
- Luesse H, Schiefer J, Spruenken A, Puls C, Block F, Kosinski C. Evaluation of R6/2 HD transgenic mice for therapeutic studies in Huntington's disease: behavioral testing and impact of diabetes mellitus. Behav Brain Res. 2001;126:185-95 pubmed..These results suggest that diabetes mellitus is not a major contributing factor to the disease phenotype. ..
- Meijsing S, Ehrenhofer Murray A. The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae. Genes Dev. 2001;15:3169-82 pubmed
- Zander T, Kraus J, Grommes C, Schlegel U, Feinstein D, Klockgether T, et al. Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. J Neurochem. 2002;81:1052-60 pubmed..Taken together, treatment of glioma cells with PPARgamma agonists may hold therapeutic potential for the treatment of gliomas. ..
- Strieder V, Lutz W. E2F proteins regulate MYCN expression in neuroblastomas. J Biol Chem. 2003;278:2983-9 pubmed..These data suggest that E2F transcription factors are critical for both the full activation and the repression of MYCN in neuroblastomas. ..
- Engelhardt O, Boutell C, Orr A, Ullrich E, Haller O, Everett R. The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML. Exp Cell Res. 2003;283:36-50 pubmed..We propose that PKM is able to modify ND10 structure by inducing changes in the posttranslational modification of PML and by interacting with SUMO-1 modification pathways. ..
- Kubis H, Hanke N, Scheibe R, Meissner J, Gros G. Ca2+ transients activate calcineurin/NFATc1 and initiate fast-to-slow transformation in a primary skeletal muscle culture. Am J Physiol Cell Physiol. 2003;285:C56-63 pubmed
- Lubomierski N, Plotz G, Wormek M, Engels K, Kriener S, Trojan J, et al. BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors. Cancer. 2005;104:952-61 pubmed
- Boosen M, Vetterkind S, Koplin A, Illenberger S, Preuss U. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis. Exp Cell Res. 2005;311:177-91 pubmed
- Deckbar D, Birraux J, Krempler A, Tchouandong L, Beucher A, Walker S, et al. Chromosome breakage after G2 checkpoint release. J Cell Biol. 2007;176:749-55 pubmed..Strikingly, we show that checkpoint release occurs at a point when approximately three to four premature chromosome condensation breaks and approximately 20 gammaH2AX foci remain. ..
- Boy J, Schmidt T, Schumann U, Grasshoff U, Unser S, Holzmann C, et al. A transgenic mouse model of spinocerebellar ataxia type 3 resembling late disease onset and gender-specific instability of CAG repeats. Neurobiol Dis. 2010;37:284-93 pubmed publisher..Few and small intranuclear aggregates appeared first at the age of 18 months, further supporting the claim that neuronal dysfunction precedes the formation of intranuclear aggregates...
- Slater E, Langer P, Niemczyk E, Strauch K, Butler J, Habbe N, et al. PALB2 mutations in European familial pancreatic cancer families. Clin Genet. 2010;78:490-4 pubmed publisher..Therefore, PALB2 mutations might be causative for FPC in a small subset of European families, especially in those with an additional occurrence of breast cancer. ..
- Rolauffs S, Fackendahl P, Sahm J, Fiene G, Hoecker U. Arabidopsis COP1 and SPA genes are essential for plant elongation but not for acceleration of flowering time in response to a low red light to far-red light ratio. Plant Physiol. 2012;160:2015-27 pubmed publisher..We propose that COP1/SPA activity, via LONG HYPOCOTYL IN FR LIGHT1, is required for shade-induced modulation of the auxin biosynthesis pathway and thereby enhances cell elongation in low R:FR. ..
- Heidler J, Fysikopoulos A, Wempe F, Seimetz M, Bangsow T, Tomasovic A, et al. Sestrin-2, a repressor of PDGFR? signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD. Dis Model Mech. 2013;6:1378-87 pubmed publisher..Taken together, our results imply that SESN2 could serve as both a biomarker and as a drug target in the clinical management of COPD. ..
- Nayernia K, Nieter S, Kremling H, Oberwinkler H, Engel W. Functional and molecular characterization of the transcriptional regulatory region of the proacrosin gene. J Biol Chem. 1994;269:32181-6 pubmed..In both fragments we identified sequence elements which are present in the promoter region of the germ cell-specific genes for histone H2B and protamine 1, respectively. ..
- Straub T, Grue P, Uhse A, Lisby M, Knudsen B, Tange T, et al. The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction. J Biol Chem. 1998;273:26261-4 pubmed..A physiological role of this stimulatory mechanism seems feasible, because topoisomerase I and PSF showed a patched colocalization in A431 cell nuclei, which varied with cell cycle. ..
- Holzmann C, Mäueler W, Petersohn D, Schmidt T, Thiel G, Epplen J, et al. Isolation and characterization of the rat huntingtin promoter. Biochem J. 1998;336 ( Pt 1):227-34 pubmed..DNase I footprinting and electrophoretic mobility-shift assays were used to define the nucleotide positions and binding affinity of DNA-protein interactions. ..
- Rinderle C, Christensen H, Schweiger S, Lehrach H, Yaspo M. AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers. Hum Mol Genet. 1999;8:277-90 pubmed..N-terminal AIRE fragments deleted for the PHD domain show altered nuclear localization, suggesting that the APECED mutations may elicit their primary effects in the nucleus. ..
- Huber A, Neuhuber W, Klugbauer N, Ruth P, Allescher H. Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle. J Biol Chem. 2000;275:5504-11 pubmed..The co-localization together with the specific phosphorylation of CRP2 by cGKI in vitro and in vivo suggests that CRP2 is a novel substrate of cGKI in neurons and smooth muscle of the small intestine. ..
- Schneider D, Berry S, Rich P, Seidler A, Rogner M. A regulatory role of the PetM subunit in a cyanobacterial cytochrome b6f complex. J Biol Chem. 2001;276:16780-5 pubmed
- Uhlmann Schiffler H, Rössler O, Stahl H. The mRNA of DEAD box protein p72 is alternatively translated into an 82-kDa RNA helicase. J Biol Chem. 2002;277:1066-75 pubmed..p82 purified from HeLa cells is an ATP-dependent RNA helicase with biochemical properties almost identical to those of p72. ..
- Martin Subero J, Gesk S, Harder L, Sonoki T, Tucker P, Schlegelberger B, et al. Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma. Blood. 2002;99:1474-7 pubmed..These data indicate that REL rather than BCL11A may be the target of the 2p13 alterations in cHL. ..
- Seinsoth S, Uhlmann Schiffler H, Stahl H. Bidirectional DNA unwinding by a ternary complex of T antigen, nucleolin and topoisomerase I. EMBO Rep. 2003;4:263-8 pubmed..The data presented here suggest that nucleolin enables the formation of a functional 'helicase-swivelase' complex at the replication fork. ..
- Suer W, Dähnrich C, Schlumberger W, Stocker W. Autoantibodies in SLE but not in scleroderma react with protein-stripped nucleosomes. J Autoimmun. 2004;22:325-34 pubmed..The present study definitely proved that ANuA are highly and specifically associated with SLE but not with PSS. ..
- Jennings S, Martinez Sobrido L, Garcia Sastre A, Weber F, Kochs G. Thogoto virus ML protein suppresses IRF3 function. Virology. 2005;331:63-72 pubmed..Surprisingly, however, ML did not interfere with the nuclear transport of IRF3. Thus, the action of ML differs strikingly from that of FLUAV NS1 that prevents IFN induction by retaining IRF3 in the cytoplasm. ..
- Moldovan G, Pfander B, Jentsch S. PCNA controls establishment of sister chromatid cohesion during S phase. Mol Cell. 2006;23:723-32 pubmed..Our study thus indicates that PCNA, a central matchmaker for replication-linked functions, is also crucially involved in the establishment of cohesion in S phase. ..
- Worch S, Fiedler E, Hansmann I, Schlote D. Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human. Cytogenet Genome Res. 2006;115:23-9 pubmed..Based on the transcriptional data we therefore assume scapinin to have a distinct biological function in the mammalian brain. ..
- Tzvetkov N, Breuer P. Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes. Biol Chem. 2007;388:973-8 pubmed..These results establish JD-containing proteins as a novel family of active de-ubiquitination enzymes with wide phylogenic distribution. ..
- Gatz S, Keimling M, Baumann C, Dork T, Debatin K, Fulda S, et al. Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner. Carcinogenesis. 2008;29:519-27 pubmed publisher..Repression of error-prone recombination subpathways could at least partially explain the chemopreventive effects of this natural plant constituent in animal cancer models. ..
- Schiefner A, Chatwell L, Körner J, Neumaier I, Colby D, Volkmer R, et al. A disulfide-free single-domain V(L) intrabody with blocking activity towards huntingtin reveals a novel mode of epitope recognition. J Mol Biol. 2011;414:337-55 pubmed publisher..Notably, this noncanonical mode of antigen binding may occur more widely in the area of in vitro selected antibody fragments, including other Ig-like scaffolds, possibly even if a V(H) domain is present. ..
- Draaken M, Prins W, Zeidler C, Hilger A, Mughal S, Latus J, et al. Involvement of the WNT and FGF signaling pathways in non-isolated anorectal malformations: sequencing analysis of WNT3A, WNT5A, WNT11, DACT1, FGF10, FGFR2 and the T gene. Int J Mol Med. 2012;30:1459-64 pubmed publisher..However, further studies should consider genes encoding other proteins in the WNT/FGF signaling pathways as possible candidates. ..
- Zhang Y, Madl T, Bagdiul I, Kern T, Kang H, Zou P, et al. Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition. Nucleic Acids Res. 2013;41:1343-54 pubmed publisher..Our results indicate that the helix-hairpin domain of SF1 is required for cooperative 3'-splice site recognition presumably by stabilizing a unique quaternary arrangement of the SF1-U2AF65-RNA complex. ..
- Stehling O, Mascarenhas J, Vashisht A, Sheftel A, Niggemeyer B, Rösser R, et al. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. Cell Metab. 2013;18:187-98 pubmed publisher..In summary, CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization. ..
- Wagner S, Oehler H, Voigt A, Dalic D, Freiwald A, Serve H, et al. ATR inhibition rewires cellular signaling networks induced by replication stress. Proteomics. 2016;16:402-16 pubmed publisher..We establish that ATR inhibition rewires cellular signaling networks induced by replication stress and leads to the activation of the ATM-driven double-strand break repair signaling. ..
- Zink L, Delbarre E, Eberl H, Keilhauer E, Bönisch C, Pünzeler S, et al. H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements. Nucleic Acids Res. 2017;45:5691-5706 pubmed publisher..These data demonstrate that H3.Y's unique amino acids allow a functional distinction between HIRA and DAXX binding and its consequent deposition into open chromatin. ..
- Meissner R, Theres K. Isolation and characterization of the tomato homeobox gene THOM1. Planta. 1995;195:541-7 pubmed..The THOM1 gene is located in the centromere region of chromosome 1 and belongs to a small gene family of the tomato genome. ..
- Hofmann Y, Becker J, Wright F, Avner E, Mrug M, Guay Woodford L, et al. Genomic structure of the gene for the human P1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease. Eur J Hum Genet. 2000;8:163-6 pubmed..Although neither marker was informative in these individuals, they are the closest yet described for PKHD1 and may help to refine the candidate region. ..
- Brummer T, Shaw P, Reth M, Misawa Y. Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J. 2002;21:5611-22 pubmed..Our study shows that BCR-mediated ERK activation involves a cooperation of both B-Raf and Raf-1, which are activated specifically in a temporally distinct manner. ..
- Damianov A, Kann M, Lane W, Bindereif A. Human RBM28 protein is a specific nucleolar component of the spliceosomal snRNPs. Biol Chem. 2006;387:1455-60 pubmed..Our data provide the first evidence that RBM28 is a common nucleolar component of the spliceosomal ribonucleoprotein complexes, possibly coordinating their transition through the nucleolus. ..
- Chadt A, Leicht K, Deshmukh A, Jiang L, Scherneck S, Bernhardt U, et al. Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity. Nat Genet. 2008;40:1354-9 pubmed publisher..Our data strongly suggest that mutation of Tbc1d1 suppresses high-fat diet-induced obesity by increasing lipid use in skeletal muscle. ..
- He H, Fokas E, You A, Engenhart Cabillic R, An H. Siah1 proteins enhance radiosensitivity of human breast cancer cells. BMC Cancer. 2010;10:403 pubmed publisher..These findings suggest that development of drugs augmenting Siah1 and Siah1L activity could be a novel approach in improving tumor cell kill. ..
- Krebs I, Weis I, Hudler M, Rommens J, Roth H, Scherer S, et al. Translocation breakpoint maps 5 kb 3' from TWIST in a patient affected with Saethre-Chotzen syndrome. Hum Mol Genet. 1997;6:1079-86 pubmed
- Reuter S, Bartelmann M, Vogt M, Geisen C, Napierski I, Kahn T, et al. APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity. EMBO J. 1998;17:215-22 pubmed..These characteristics make APM-1, the first novel human gene identified in a HPV integration region, a likely candidate for the postulated tumour suppressor gene. ..
- Gottschalk A, Tang J, Puig O, Salgado J, Neubauer G, Colot H, et al. A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins. RNA. 1998;4:374-93 pubmed..Finally, we show that Nam8p/Mud15p contributes to the stability of U1 snRNP. ..
- Zuniga A, Zeller R. Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity. Development. 1999;126:13-21 pubmed..Concurrently, Gli3 functions independently of formin during initial posterior nesting of 5'HoxD domains, whereas their subsequent distal restriction and anterior expansion depends on genetic interaction of Gli3 and formin. ..
- Katahira J, Strasser K, Podtelejnikov A, Mann M, Jung J, Hurt E. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J. 1999;18:2593-609 pubmed..Thus, the human TAP-p15 complex can functionally replace the Mex67p-Mtr2p complex in yeast and thus performs a conserved role in nuclear mRNA export...
- Stanewsky R, Lynch K, Brandes C, Hall J. Mapping of elements involved in regulating normal temporal period and timeless RNA expression patterns in Drosophila melanogaster. J Biol Rhythms. 2002;17:293-306 pubmed..The results establish that, for normal rhythmicity, expression of clock genes requires regulation at the transcriptional, posttranscriptional, and posttranslational levels. ..
- Zhang Z, Lutz B. Cre recombinase-mediated inversion using lox66 and lox71: method to introduce conditional point mutations into the CREB-binding protein. Nucleic Acids Res. 2002;30:e90 pubmed..Our results indicate that this Cre- mediated inversion method is a valuable tool to introduce point mutations in the mouse genome in a regulatable manner...
- Kramps C, Strieder V, Sapetschnig A, Suske G, Lutz W. E2F and Sp1/Sp3 Synergize but are not sufficient to activate the MYCN gene in neuroblastomas. J Biol Chem. 2004;279:5110-7 pubmed
- Möller A, Sirma H, Hofmann T, Staege H, Gresko E, Lüdi K, et al. Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression. Oncogene. 2003;22:8731-7 pubmed..In summary, these experiments reveal a novel function for Sp100 as a coactivator for HIPK2-mediated p53 activation. ..
- Hellwig Burgel T, Stiehl D, Katschinski D, Marxsen J, Kreft B, Jelkmann W. VEGF production by primary human renal proximal tubular cells: requirement of HIF-1, PI3-kinase and MAPKK-1 signaling. Cell Physiol Biochem. 2005;15:99-108 pubmed..Furthermore, hypoxia alone was sufficient to activate PI3K in PTEC in contrast to MAPKK-1, whose activity was lowered in hypoxia. ..
- Dreikhausen U, Hiebenthal Millow K, Bartels M, Resch K, Nourbakhsh M. NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor. Mol Cell Biol. 2005;25:7473-83 pubmed..Our data suggest that NRF interrupts the regulatory coupling of LTR binding factors and transcription elongation events. This inhibitory mechanism might contribute to transcriptional quiescence of integrated HIV-1 provirus. ..
- Koelzer S, Klein T. Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. Dev Biol. 2006;289:77-90 pubmed..Thus, de-repression of its target genes obscures the involvement of Su(H) in this process. Furthermore, we provide evidence that Dx does not signal in a Su(H)-independent manner as has been suggested previously. ..
- Unger K, Malisch E, Thomas G, Braselmann H, Walch A, Jackl G, et al. Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC. Oncogene. 2008;27:4592-602 pubmed publisher..In contrast, alterations in RET/PTC-negative tumours indicate alternative routes of tumour development. The data presented serve as a starting point for further studies on gene expression and function of genes identified in this study. ..
- Qualmann B, Kessels M. Actin nucleation: putting the brakes on Arp2/3. Curr Biol. 2008;18:R420-R423 pubmed publisher..This brake can suppress both the basal activity of the Arp2/3 complex as well as its activation by nucleation-promoting factors. ..
- Sagan D, Müller R, Kröger C, Hematulin A, Mörtl S, Eckardt Schupp F. The DNA repair protein NBS1 influences the base excision repair pathway. Carcinogenesis. 2009;30:408-15 pubmed publisher..Our data presented here highlight for the first time a functional role for NBS1 in DNA maintenance by the BER pathway. ..
- Kr ger A, Batsios P, Baumann O, Luckert E, Schwarz H, Stick R, et al. Characterization of NE81, the first lamin-like nucleoskeleton protein in a unicellular organism. Mol Biol Cell. 2012;23:360-70 pubmed publisher..The discovery of a lamin-like protein in a unicellular organism is not only intriguing in light of evolution, it may also provide a simple experimental platform for studies of the molecular basis of laminopathies...
- Tran D, Saran S, Dittrich Breiholz O, Williamson A, Klebba Färber S, Koch A, et al. Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation. Cell Death Dis. 2013;4:e879 pubmed publisher..In conclusion, regulation of immediate-early gene response by THOC5, a member of mRNA export complex contributes to the M-CSF-induced macrophage differentiation. ..
- Lehmann M, Wattler F, Korge G. Two new regulatory elements controlling the Drosophila Sgs-3 gene are potential ecdysone receptor and fork head binding sites. Mech Dev. 1997;62:15-27 pubmed..Since also the Sgs-4 gene is controlled by a functional EcR/USP binding site, a direct participation of EcR/USP in the formation of regulatory complexes may be of general importance for the hormonal control of Sgs genes. ..
- Schlenstedt G, Smirnova E, Deane R, Solsbacher J, Kutay U, Gorlich D, et al. Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J. 1997;16:6237-49 pubmed..L25 binds to Yrb4p and Pse1p and is released by Gsp1p-GTP. Consistent with its putative role as an import receptor for L25-like proteins, Yrb4p localizes to the cytoplasm, the nucleoplasm and the NPC. ..
- Lun K, Brand M. A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary. Development. 1998;125:3049-62 pubmed..We propose that noi/pax2.1 participates in sequential signaling processes as a key integrator of midbrain-hindbrain boundary development. ..
- Negeri D, Eggert H, Gienapp R, Saumweber H. Inducible RNA interference uncovers the Drosophila protein Bx42 as an essential nuclear cofactor involved in Notch signal transduction. Mech Dev. 2002;117:151-62 pubmed..Target genes of Notch signaling like cut and Enhancer of split m8 were suppressed by induction of Bx42 RNAi. Our results demonstrate that inducible RNAi is a powerful tool to study the role of essential genes throughout development...
- Langheinrich U, Hennen E, Stott G, Vacun G. Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr Biol. 2002;12:2023-8 pubmed..We conclude that zebrafish represents a promising model organism for future compound-based and genetic screens and believe that it will help to identify and characterize new anticancer drugs and new targets for cancer treatment. ..
- Vantler M, Caglayan E, Zimmermann W, Bäumer A, Rosenkranz S. Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important. J Biol Chem. 2005;280:14168-76 pubmed..We conclude that growth factor-dependent cell survival in VSMC is mediated only by activation of the PI3K/Akt pathway, whereas all other receptor-associated signaling molecules do not play a significant role. ..
- Ebelt H, Hufnagel N, Neuhaus P, Neuhaus H, Gajawada P, Simm A, et al. Divergent siblings: E2F2 and E2F4 but not E2F1 and E2F3 induce DNA synthesis in cardiomyocytes without activation of apoptosis. Circ Res. 2005;96:509-17 pubmed..Our finding that expression of E2F2 induces cell division of cardiomyocytes along with a suppression of proapoptotic genes might open a new access to improve the regenerative capacity of cardiomyocytes. ..
- Büttner B, Kannicht C, Reutter W, Horstkorte R. Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A. Biochemistry. 2005;44:6938-47 pubmed..For this purpose, we performed GST pull-down experiments using cytosolic fragments of NCAM as GST-fusion proteins and cytosolic- or cytoskeleton-enriched protein fractions of rat brain. ..
- Casenghi M, Barr F, Nigg E. Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome. J Cell Sci. 2005;118:5101-8 pubmed..These findings uncover a mechanism through which Plk1 helps to coordinate changes in MT organisation with cell cycle progression, by controlling the dynein-dynactin-dependent transport of centrosomal proteins. ..
- Stolt C, Schlierf A, Lommes P, Hillgärtner S, Werner T, Kosian T, et al. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell. 2006;11:697-709 pubmed..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development. ..
- Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan S, Handa V, et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature. 2007;445:671-5 pubmed..Active demethylation occurs by DNA repair and Gadd45a interacts with and requires the DNA repair endonuclease XPG. We conclude that Gadd45a relieves epigenetic gene silencing by promoting DNA repair, which erases methylation marks. ..