Experts and Doctors on nuclear proteins in Czech Republic
Locale: Czech Republic
Topic: nuclear proteins
Dostálová A, Käser S, Cristodero M, Schimanski B. The nuclear mRNA export receptor Mex67-Mtr2 of Trypanosoma brucei contains a unique and essential zinc finger motif. Mol Microbiol. 2013;88:728-39 pubmed publisher
..Our data show that the general heterodimeric export receptor Mex67-Mtr2 is conserved throughout the eukaryotic kingdom albeit exhibiting parasite-specific features. ..
Fuchsova B, Novak P, Kafková J, Hozak P. Nuclear DNA helicase II is recruited to IFN-alpha-activated transcription sites at PML nuclear bodies. J Cell Biol. 2002;158:463-73 pubmed
..Based on the data, we suggest that NDH II recruitment to PML NBs is connected with transcriptional regulation of interferon-alpha-inducible genes attached to PML NBs. ..
Novakova Z, Man P, Novak P, Hozak P, Hodny Z. Separation of nuclear protein complexes by blue native polyacrylamide gel electrophoresis. Electrophoresis. 2006;27:1277-87 pubmed
..Moreover, practical advice for sample preparation is provided. ..
Skalnikova H, Martinkova J, Hrabakova R, Halada P, Dziechciarkova M, Hajduch M, et al
. Cancer drug-resistance and a look at specific proteins: Rho GDP-dissociation inhibitor 2, Y-box binding protein 1, and HSP70/90 organizing protein in proteomics clinical application. J Proteome Res. 2011;10:404-15 pubmed publisher
..Furthermore, these proteins were validated for their roles in drug resistance using different cell lines resistant to diverse representatives of anti-cancer drugs such as vincristine and daunorubicin. ..
Sevcik J, Falk M, Macurek L, Kleiblova P, Lhota F, Hojny J, et al
. Expression of human BRCA1?17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response. Cell Signal. 2013;25:1186-93 pubmed publisher
..Our findings indicate that expression of BRCA1?17-19 may negatively influence genome stability by reducing the DDSB repair velocity, thereby contributing to enhanced probability of cancer development in the affected families. ..
Hovsepian J, DefenouillÃ¨re Q, AlbanÃ¨se V, VÃ¡chovÃ¡ L, García C, PalkovÃ¡ Z, et al
. Multilevel regulation of an Î±-arrestin by glucose depletion controls hexose transporter endocytosis. J Cell Biol. 2017;216:1811-1831 pubmed publisher
..Thus, two glucose signaling pathways converge onto Csr2 to regulate hexose transporter endocytosis by glucose availability. These data illustrate novel mechanisms by which nutrients modulate ART activity and endocytosis. ..
Kozmik Z, Pfeffer P, Kralova J, Paces J, Paces V, Kalousova A, et al
. Molecular cloning and expression of the human and mouse homologues of the Drosophila dachshund gene. Dev Genes Evol. 1999;209:537-45 pubmed
..RT/PCR analysis readily detected Dach mRNA in the adult mouse cornea and retina. Dach mRNA expression in the mouse E11.5 embryo was observed primarily in the fore and hind limbs, as well as in the somites. ..
Seemanova E, Jarolim P, Seeman P, Varon R, Digweed M, Swift M, et al
. Cancer risk of heterozygotes with the NBN founder mutation. J Natl Cancer Inst. 2007;99:1875-80 pubmed
..7, 95% CI = 1.4 to 81.5; P<.004). The NBN 657del5 mutation appears to be associated with an elevated risk of cancer in heterozygotes. ..
Galiova G, Bartova E, Raska I, Krejci J, Kozubek S. Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A. Eur J Cell Biol. 2008;87:291-303 pubmed publisher