Experts and Doctors on nfi transcription factors in United States


Locale: United States
Topic: nfi transcription factors

Top Publications

  1. Capowski E, Esnault S, Bhattacharya S, Malter J. Y box-binding factor promotes eosinophil survival by stabilizing granulocyte-macrophage colony-stimulating factor mRNA. J Immunol. 2001;167:5970-6 pubmed
    ..Thus, we propose a model whereby activation of eosinophils leads to YB-1 binding to and stabilization of GM-CSF mRNA, ultimately resulting in GM-CSF release and prolonged eosinophil survival. ..
  2. Steele Perkins G, Plachez C, Butz K, Yang G, Bachurski C, Kinsman S, et al. The transcription factor gene Nfib is essential for both lung maturation and brain development. Mol Cell Biol. 2005;25:685-98 pubmed
    ..The similarity in brain defects in Nfia- and Nfib-deficient animals suggests that these two genes may cooperate in late fetal forebrain development, while Nfib is essential for late fetal lung maturation and development of the pons. ..
  3. Liang B, Tikhanovich I, Nasheuer H, Folk W. Stimulation of BK virus DNA replication by NFI family transcription factors. J Virol. 2012;86:3264-75 pubmed publisher
    ..These results suggest that NFI proteins (and the signaling pathways that target them) activate BKV replication and contribute to the consequent pathologies caused by acute infection. ..
  4. Hebert S, Simmons C, Thompson A, Zorc C, Blalock E, Kraner S. Basic helix-loop-helix factors recruit nuclear factor I to enhance expression of the NaV 1.4 Na+ channel gene. Biochim Biophys Acta. 2007;1769:649-58 pubmed
    ..Mutation of the NFI-binding sites diminished the ability of myogenin and MRF4 to counteract repression. Based on these observations we suggest that bHLH factors recruit NFI to enhance skeletal muscle Na(+) channel expression. ..
  5. Yu J, Gattoni Celli M, Zhu H, Bhat N, Sambamurti K, Gattoni Celli S, et al. Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice. J Alzheimers Dis. 2011;25:295-307 pubmed publisher
    ..These observations suggest that a vitamin D3-enriched diet may benefit AD patients. ..
  6. Rettig E, Talbot C, Sausen M, Jones S, Bishop J, Wood L, et al. Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prev Res (Phila). 2016;9:265-74 pubmed publisher
    ..Our findings suggest a separate role for NFIB in ACC oncogenesis and highlight important signaling pathways for future functional characterization and potential therapeutic targeting. ..
  7. Leahy P, Crawford D, Grossman G, Gronostajski R, Hanson R. CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription. J Biol Chem. 1999;274:8813-22 pubmed
    ..NFI-A combines with dexamethasone or thyroid hormone in an additive manner to stimulate PEPCK gene transcription. We conclude that CBP coordinates the action of the multiple factors known to control transcription of the PEPCK gene. ..
  8. Jun G, Chung J, Mez J, Barber R, Beecham G, Bennett D, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017;13:727-738 pubmed publisher
    ..7 × 10-6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10-6). Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci. ..
  9. Steele Perkins G, Butz K, Lyons G, Zeichner David M, Kim H, Cho M, et al. Essential role for NFI-C/CTF transcription-replication factor in tooth root development. Mol Cell Biol. 2003;23:1075-84 pubmed
    ..The Nfic mutation is the first mutation described that affects primarily tooth root formation and should greatly aid our understanding of postnatal tooth development. ..

More Information


  1. Pan L, Glenn S, Jones C, Gronostajski R, Gross K. Regulation of renin enhancer activity by nuclear factor I and Sp1/Sp3. Biochim Biophys Acta. 2003;1625:280-90 pubmed
    ..Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assays have demonstrated that NFI-X is the predominant NFI mRNA expressed in As4.1 cells. Direct study of involvement of NFI-X in regulation of renin genes is underway. ..
  2. Bandyopadhyay S, Starke D, Mieyal J, Gronostajski R. Thioltransferase (glutaredoxin) reactivates the DNA-binding activity of oxidation-inactivated nuclear factor I. J Biol Chem. 1998;273:392-7 pubmed
  3. McClure C, Ali E, Youssef D, Yao Z, McCall C, El Gazzar M. NFI-A disrupts myeloid cell differentiation and maturation in septic mice. J Leukoc Biol. 2016;99:201-11 pubmed publisher
    ..We suggest that therapeutically targeting nuclear factor 1 A type during late sepsis might improve survival. ..
  4. Muthusamy N, Chen H, Rajgolikar G, Butz K, Frissora F, Gronostajski R. Recombination activation gene-2-deficient blastocyst complementation analysis reveals an essential role for nuclear factor I-A transcription factor in T-cell activation. Int Immunol. 2011;23:385-90 pubmed publisher
    ..These studies demonstrate for the first time a requirement for the NFI-A transcription factor in antigen receptor-induced T-cell activation events. ..
  5. Deneen B, Ho R, Lukaszewicz A, Hochstim C, Gronostajski R, Anderson D. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron. 2006;52:953-68 pubmed
    ..At later stages, NFIA promotes migration and differentiation of astrocyte precursors, a function that is antagonized in oligodendrocyte precursors by Olig2. ..
  6. Dai J, Kumbhare A, Youssef D, Yao Z, McCall C, El Gazzar M. Expression of C/EBPβ in myeloid progenitors during sepsis promotes immunosuppression. Mol Immunol. 2017;91:165-172 pubmed publisher
    ..Together, these results support that decreasing C/EBPβ expression prevents MDSC generation and decreases immunosuppression in septic mice, providing a target for sepsis treatment. ..
  7. Glasgow S, Carlson J, Zhu W, Chaboub L, Kang P, Lee H, et al. Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci. 2017;20:1520-1528 pubmed publisher
    ..By delineating three-dimensional mechanisms of gene expression regulation, our studies identify lineage-specific chromatin architectures and associated enhancers that regulate cell fate and tumorigenesis in the CNS. ..
  8. Lazakovitch E, Kalb J, Gronostajski R. Lifespan extension and increased pumping rate accompany pharyngeal muscle-specific expression of nfi-1 in C. elegans. Dev Dyn. 2008;237:2100-7 pubmed publisher
    ..We propose some relationships between the pharyngeal pumping and lifespan phenotypes and potential mechanisms of nfi-1 function. ..
  9. Lazakovitch E, Kalb J, Matsumoto R, Hirono K, Kohara Y, Gronostajski R. nfi-I affects behavior and life-span in C. elegans but is not essential for DNA replication or survival. BMC Dev Biol. 2005;5:24 pubmed
    ..The phenotype of nfi-1 null worms indicates that NFI functions in multiple developmental and behavioral systems in C. elegans, likely regulating genes that function in motility, egg-laying, pharyngeal pumping and lifespan maintenance. ..
  10. Shnyreva M, Schullery D, Suzuki H, Higaki Y, Bomsztyk K. Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein. J Biol Chem. 2000;275:15498-503 pubmed
    ..Each protein was able to transactivate transcription from a polypyrimidine-rich promoter; however, this effect was reduced when K and YB-1 proteins were coexpressed suggesting a functional interaction between these two proteins. ..
  11. Chaudhry A, Vitullo A, Gronostajski R. Nuclear factor I-mediated repression of the mouse mammary tumor virus promoter is abrogated by the coactivators p300/CBP and SRC-1. J Biol Chem. 1999;274:7072-81 pubmed
    ..This abrogation of NFI-C-mediated repression by p300/CBP and SRC-1A suggests that repression by NFI-C may occur by interference with coactivator function at the MMTV promoter. ..
  12. Chaudhry A, Vitullo A, Gronostajski R. Nuclear factor I (NFI) isoforms differentially activate simple versus complex NFI-responsive promoters. J Biol Chem. 1998;273:18538-46 pubmed
    ..Here, we show that NFI heterodimers have intermediate activation potentials compared with homodimers, demonstrating one potential mechanism by which different NFI proteins can regulate gene expression. ..