Experts and Doctors on neutrophils in Italy

Summary

Locale: Italy
Topic: neutrophils

Top Publications

  1. Marzocco S, Di Paola R, Serraino I, Sorrentino R, Meli R, Mattaceraso G, et al. Effect of methylguanidine in carrageenan-induced acute inflammation in the rats. Eur J Pharmacol. 2004;484:341-50 pubmed
  2. Donini M, Fontana S, Savoldi G, Vermi W, Tassone L, Gentili F, et al. G-CSF treatment of severe congenital neutropenia reverses neutropenia but does not correct the underlying functional deficiency of the neutrophil in defending against microorganisms. Blood. 2007;109:4716-23 pubmed
    ..Thereby, we propose that the treatment with G-CSF is not sufficient to correct all of the functional deficiency of neutrophils, and this might account for the consistent risk of infections observed in SCN patients. ..
  3. Baetta R, Silva F, Comparato C, Uzzo M, Eberini I, Bellosta S, et al. Perivascular carotid collar placement induces neointima formation and outward arterial remodeling in mice independent of apolipoprotein E deficiency or Western-type diet feeding. Atherosclerosis. 2007;195:e112-24 pubmed
    ..The murine perivascular carotid collar model would thus be suitable for investigating neointima formation, arterial remodeling, and their potential pharmacological modulation in the setting of different genetic and dietary conditions. ..
  4. Braga P, Dal Sasso M, Culici M, Spallino A, Falchi M, Bertelli A, et al. Antioxidant activity of Calendula officinalis extract: inhibitory effects on chemiluminescence of human neutrophil bursts and electron paramagnetic resonance spectroscopy. Pharmacology. 2009;83:348-55 pubmed publisher
  5. Nicolis E, Lampronti I, Dechecchi M, Borgatti M, Tamanini A, Bezzerri V, et al. Modulation of expression of IL-8 gene in bronchial epithelial cells by 5-methoxypsoralen. Int Immunopharmacol. 2009;9:1411-22 pubmed publisher
    ..In synthesis, 5-methoxypsoralen can be taken into consideration to investigate mechanisms of neutrophil chemotactic signalling and for its potential application in modulating the excessive CF lung inflammation...
  6. Marino F, Guasti L, Tozzi M, Consuelo Maio R, Castiglioni L, Rasini E, et al. Angiotensin type 1 receptor expression and interleukin-8 production in polymorphonuclear leukocytes of patients with peripheral arterial disease. J Cardiovasc Pharmacol. 2009;54:520-5 pubmed publisher
    ..In PAD patients, femoral endarterectomy is associated with reduction of AT1R expression however with no apparent effect on IL-8 production. The relevance of such effects for cardiovascular protection deserves consideration. ..
  7. Totani L, Amore C, Di Santo A, Dell Elba G, Piccoli A, Martelli N, et al. Roflumilast inhibits leukocyte-platelet interactions and prevents the prothrombotic functions of polymorphonuclear leukocytes and monocytes. J Thromb Haemost. 2016;14:191-204 pubmed publisher
    ..This study reveals novel antithrombotic activities by which roflumilast may exert protective effects against cardiovascular comorbodities in COPD. ..
  8. Fiorini G, Crespi S, Rinaldi M, Oberti E, Vigorelli R, Palmieri G. Serum ECP and MPO are increased during exacerbations of chronic bronchitis with airway obstruction. Biomed Pharmacother. 2000;54:274-8 pubmed
    ..We conclude that serum ECP and MPO are increased during the exacerbations of COPD. These observations can give a basis for further studies aimed to evaluate the utility of these two proteins as markers of activity and severity of COPD. ..
  9. Decleva E, Dri P, Menegazzi R, Busetto S, Cramer R. Evidence that TNF-induced respiratory burst of adherent PMN is mediated by integrin alpha(L)beta(2). J Leukoc Biol. 2002;72:718-26 pubmed
    ..The nonpermissiveness of laminin appears to be a consequence of its inability to act as a ligand for alpha(L)beta(2). ..

More Information

Publications144 found, 100 shown here

  1. Fontana L, Giagulli C, Cominacini L, Pasini A, Minuz P, Lechi A, et al. Beta2 integrin-dependent neutrophil adhesion induced by minimally modified low-density lipoproteins is mainly mediated by F2-isoprostanes. Circulation. 2002;106:2434-41 pubmed
  2. Borelli V, Brochetta C, Melato M, Rizzardi C, Polentarutti M, Busatto C, et al. A procedure for the isolation of asbestos bodies from lung tissue by exploiting their magnetic properties: a new approach to asbestos body study. J Toxicol Environ Health A. 2007;70:1232-40 pubmed
  3. Mantovani A, Savino B, Locati M, Zammataro L, Allavena P, Bonecchi R. The chemokine system in cancer biology and therapy. Cytokine Growth Factor Rev. 2010;21:27-39 pubmed publisher
    ..Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies. ..
  4. Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez Ramos D, et al. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature. 2014;507:109-13 pubmed publisher
    ..Our work indicates that targeting the inflammation-induced phenotypic plasticity of melanoma cells and their association with endothelial cells represent rational strategies to specifically interfere with metastatic progression. ..
  5. Mollace V, Prosdocimi M, Nistico G. Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells. Eur J Pharmacol. 1992;222:181-4 pubmed
    ..Thus, the present results show that cloricromene possesses direct antiplatelet properties and synergizes with other endogenous as well as exogenous antiplatelet compounds. ..
  6. Ottonello L, Dapino P, Scirocco M, Balbi A, Bevilacqua M, Dallegri F. Sulphonamides as anti-inflammatory agents: old drugs for new therapeutic strategies in neutrophilic inflammation?. Clin Sci (Lond). 1995;88:331-6 pubmed
    ..They can also be viewed as a previously unrecognized starting point for the development of new compounds in order to plan rational therapeutic strategies for controlling tissue injury during neutrophilic inflammation. ..
  7. Gasperini S, Calzetti F, Russo M, De Gironcoli M, Cassatella M. Regulation of GRO alpha production in human granulocytes. J Inflamm. 1995;45:143-51 pubmed
    ..These findings identify a novel biological function of PMN, likely involved in the modulation of the acute inflammatory response. ..
  8. Tullio V, Cuffini A, Bonino A, Giacchino F, Merlino C, Bosticardo G, et al. Cefonicid 'restores' the depressed activities of polymorphonuclear cells from chronic haemodialysis patients and renal transplant recipients in vitro. Nephrol Dial Transplant. 1998;13:2017-22 pubmed
    ..Cefonicid, with its several immunoproperties observed in this study, possesses interesting beneficial properties which make it suitable for the treatment of infections in patients with impaired components of the immune system. ..
  9. Braga P, Dal Sasso M, Fonti E, Culici M. Antioxidant activity of bisabolol: inhibitory effects on chemiluminescence of human neutrophil bursts and cell-free systems. Pharmacology. 2009;83:110-5 pubmed publisher
    ..These findings draw the attention to the possible medical use of bisabolol as a means of improving the antioxidant network and restoring the redox balance by antagonising oxidative stress. ..
  10. Arfilli V, Carnicelli D, Rocchi L, Ricci F, Pagliaro P, Tazzari P, et al. Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor. Biochem J. 2010;432:173-80 pubmed publisher
    ..These observations reveal that the Stx-PMN interaction is specific, confirming that PMN recognize molecular patterns common to different foreign molecules. ..
  11. Cicala C, Cirino G. Phospholipase A2-induced hypotension in the rat and its pharmacological modulation. Gen Pharmacol. 1993;24:1197-202 pubmed
    ..v.) was ineffective. 6. In rats rendered leucopenic with methotrexate the L-649,923 was ineffective implying that the L-649,923 effect could be partially mediated through its action on neutrophils. ..
  12. Lanza F. Clinical manifestation of myeloperoxidase deficiency. J Mol Med (Berl). 1998;76:676-81 pubmed
    ..The advantage of MPO monoclonal antibodies over the MPO cytochemical assay relies in the ability of the former method to recognize the enzymatically inactive precursor forms of MPO. ..
  13. Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Ciccolo A, Centorrino T, et al. Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat. FASEB J. 2001;15:1187-200 pubmed
    ..Our results clearly demonstrate that NAC treatment exerts a protective effect and clearly indicate that NAC offers a novel therapeutic approach for the management of lung injury where radicals have been postulated to play a role. ..
  14. Mocsai A, Ligeti E, Lowell C, Berton G. Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol. 1999;162:1120-6 pubmed
  15. Cuzzocrea S, Santagati S, Sautebin L, Mazzon E, Calabro G, Serraino I, et al. 17beta-estradiol antiinflammatory activity in carrageenan-induced pleurisy. Endocrinology. 2000;141:1455-63 pubmed
    ..We conclude that E2 attenuates the degree of inflammation and tissue damage associated with carrageenan-induced pleurisy in the rat. ..
  16. Menegazzi M, Di Paola R, Mazzon E, Muià C, Genovese T, Crisafulli C, et al. Hypericum perforatum attenuates the development of carrageenan-induced lung injury in mice. Free Radic Biol Med. 2006;40:740-53 pubmed
    ..perforatum extract treatment. Taken together, our results indicate that prevention of the activation of NF-kappaB and STAT-3 by H. perforatum extract reduces the development of acute inflammation. ..
  17. Sallese M, Lombardi M, De Blasi A. Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning. Biochem Biophys Res Commun. 1994;199:848-54 pubmed
    ..This demonstrates the existence of two isoforms of GRK4 which were named GRK4A and GRK4B in the presence or absence of the insert, respectively. This is the first evidence that, within the GRKs gene family, different isoforms do exist. ..
  18. Sartorelli P, Panelli S, Comazzi S, Paltrinieri S. Isolation stress in sheep: effects on neutrophil gene expression of CD18, IL8 and C5a receptors. Vet Res Commun. 2003;27 Suppl 1:351-3 pubmed
  19. Bertelli R, Trivelli A, Magnasco A, Cioni M, Bodria M, Carrea A, et al. Failure of regulation results in an amplified oxidation burst by neutrophils in children with primary nephrotic syndrome. Clin Exp Immunol. 2010;161:151-8 pubmed publisher
    ..Regulatory T cells (Tregs) and CD20 are probably involved in this regulation. Overall, our observations reinforce the concept that oxidants deriving from PMN are implicated in iNS...
  20. Ottonello L, Epstein A, Dapino P, Barbera P, Morone P, Dallegri F. Monoclonal Lym-1 antibody-dependent cytolysis by neutrophils exposed to granulocyte-macrophage colony-stimulating factor: intervention of FcgammaRII (CD32), CD11b-CD18 integrins, and CD66b glycoproteins. Blood. 1999;93:3505-11 pubmed
  21. Todeschini M, Macconi D, Fernández N, Ghilardi M, Anabaya A, Binda E, et al. Effect of acetate-free biofiltration and bicarbonate hemodialysis on neutrophil activation. Am J Kidney Dis. 2002;40:783-93 pubmed
    ..AFB, unlike BHD, does not cause PMN and monocyte activation, which could have a positive impact on dialysis-associated cardiovascular disease of dialyzed patients. ..
  22. Guidetti F, Grazioli S, Capelli F, Marini C, Gallicchio M, De Micheli D, et al. Primitive hematopoietic stem cells shows a polyclonal pattern in myelodysplastic syndromes. Haematologica. 2004;89:21-8 pubmed
    ..In myelodysplastic syndromes, hematopoiesis may be dominated by a neoplastic clone by virtue of its biological advantage over a residual polyclonal, probably still normal, population of immature stem cells still able to grow in vitro. ..
  23. Maugeri N, Rovere Querini P, Evangelista V, Covino C, Capobianco A, Bertilaccio M, et al. Neutrophils phagocytose activated platelets in vivo: a phosphatidylserine, P-selectin, and {beta}2 integrin-dependent cell clearance program. Blood. 2009;113:5254-65 pubmed publisher
    ..The data suggest that the interaction between circulating platelets and neutrophils influences innate immune functions, possibly contributing to regulate vascular inflammation. ..
  24. Bellavite P, Bazzoni F, Cassatella M, Hunter K, Bannister J. Isolation and characterization of a cDNA clone for a novel serine-rich neutrophil protein. Biochem Biophys Res Commun. 1990;170:915-22 pubmed
    ..The isolated cDNA hybridizes with a 3.1 kb mRNA expressed in pig and human leukocytes. ..
  25. Dalpiaz A, Spisani S, Biondi C, Fabbri E, Nalli M, Ferretti M. Studies on human neutrophil biological functions by means of formyl-peptide receptor agonists and antagonists. Curr Drug Targets Immune Endocr Metabol Disord. 2003;3:33-42 pubmed
  26. Bottai D, Cigognini D, Madaschi L, Adami R, Nicora E, Menarini M, et al. Embryonic stem cells promote motor recovery and affect inflammatory cell infiltration in spinal cord injured mice. Exp Neurol. 2010;223:452-63 pubmed publisher
    ..No teratoma formation was observed, although an inappropriate colonization of the sacral cord by differentiated nestin- and beta-tubulin III-positive ESCs was detected. ..
  27. Calvillo L, Vanoli E, Andreoli E, Besana A, Omodeo E, Gnecchi M, et al. Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion. J Cardiovasc Pharmacol. 2011;58:500-7 pubmed publisher
    ..The vagally mediated modulation of inflammatory responses may prove valuable in the clinical management of acute coronary syndromes and of heart failure. ..
  28. Piattelli A, Rubini C, Fioroni M, Favero L, Strocchi R. Expression of transforming growth factor-beta 1 (TGF-beta 1) in odontogenic cysts. Int Endod J. 2004;37:7-11 pubmed
    ..To evaluate the positivity to transforming growth factor-beta 1 (TGF-beta 1) in different types of odontogenic cysts...
  29. Zanetti M, Del Sal G, Storici P, Schneider C, Romeo D. The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibiotics. J Biol Chem. 1993;268:522-6 pubmed
    ..The COOH-terminal sequences of these antibiotics are completely unrelated. The proregion also exhibits remarkable similarity to pig cathelin, an inhibitor of cathepsin L, indicating a common evolutionary origin. ..
  30. Cuzzocrea S, Zingarelli B, Costantino G, Caputi A. Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in carrageenan-induced pleurisy. Free Radic Biol Med. 1999;26:25-33 pubmed
    ..Part of these anti-inflammatory effects may be related to: (1) reduction of superoxide formation due to the superoxide dismutase-like activity of the compound and (2) scavenging of peroxynitrite. ..
  31. Cilibrizzi A, Quinn M, Kirpotina L, Schepetkin I, Holderness J, Ye R, et al. 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors. J Med Chem. 2009;52:5044-57 pubmed publisher
    ..Agonists were able to activate intracellular calcium mobilization and chemotaxis in human neutrophils. The most potent chemotactic agent (EC(50) = 0.6 microM) was the mixed FPR/FPRL1 agonist 14h. ..
  32. Capsoni F, Ongari A, Reali E, Catania A. Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells. Arthritis Res Ther. 2009;11:R151 pubmed publisher
    ..These findings reinforce previous observations on the potential role of alpha-MSH and related peptides as a new class of drugs for treatment of inflammatory arthritis. ..
  33. Ribaldi E, Mezzasoma A, Francescangeli E, Prosdocimi M, Nenci G, Goracci G, et al. Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation. Br J Pharmacol. 1996;118:1351-8 pubmed
  34. Pellegatta F, Chierchia S, Zocchi M. Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils. J Biol Chem. 1998;273:27768-71 pubmed
    ..In conclusion, PECAM-1/CD31 appears to be one of the molecules functionally coupled to PI3K, suggesting that this enzyme may represent a common pathway of integrin and adhesiveness regulation in leukocytes. ..
  35. Benelli R, Morini M, Carrozzino F, Ferrari N, Minghelli S, Santi L, et al. Neutrophils as a key cellular target for angiostatin: implications for regulation of angiogenesis and inflammation. FASEB J. 2002;16:267-9 pubmed
    ..These data show that angiostatin directly inhibits neutrophil migration and neutrophil-mediated angiogenesis and indicate that angiostatin might inhibit inflammation. ..
  36. Di Gennaro A, Carnini C, Buccellati C, Ballerio R, Zarini S, Fumagalli F, et al. Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl-leukotrienes. FASEB J. 2004;18:842-4 pubmed
  37. Cassatella M, Mosna F, Micheletti A, Lisi V, Tamassia N, Cont C, et al. Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils. Stem Cells. 2011;29:1001-11 pubmed publisher
    ..Our data highlight a novel mechanism by which MSC sustain and amplify the functions of PMN in response to TLR3- and TLR4-triggering and may consequently contribute to inflammatory disorders. ..
  38. Cauci S, Guaschino S, de Aloysio D, Driussi S, De Santo D, Penacchioni P, et al. Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women. Mol Hum Reprod. 2003;9:53-8 pubmed
    ..The lack of an increase in IL-8 may explain the absence of an increase in neutrophil numbers in most women exposed to abnormal vaginal colonization (BV). ..
  39. Di Filippo C, Rossi F, Rossi S, D Amico M. Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN. J Leukoc Biol. 2004;75:453-9 pubmed
    ..In conclusion, we demonstrate for the first time that exogenous and endogenous CB2-R activation reduces the leukocyte-dependent myocardial damage associated with an I/R procedure. ..
  40. Ortolan E, Tibaldi E, Ferranti B, Lavagno L, Garbarino G, Notaro R, et al. CD157 plays a pivotal role in neutrophil transendothelial migration. Blood. 2006;108:4214-22 pubmed
    ..These findings are relevant in vivo because CD157-deficient neutrophils obtained from patients with paroxysmal nocturnal hemoglobinuria are characterized by a severely impaired diapedesis. ..
  41. Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell Elba G, Pecce R, et al. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood. 2007;109:2461-9 pubmed
    ..These results definitely establish a role for SFKs in PMN recruitment by activated platelets and suggest novel targets to disrupt the pathophysiologic consequences of platelet-leukocyte interactions in vascular disease. ..
  42. Cauci S, Culhane J. Modulation of vaginal immune response among pregnant women with bacterial vaginosis by Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, and yeast. Am J Obstet Gynecol. 2007;196:133.e1-7 pubmed
    ..The strong proinflammatory cytokine induction by T. vaginalis may contribute to the observed increase in preterm birth among BV positive women coinfected with T. vaginalis treated with metronidazole. ..
  43. Borrelli O, Battaglia M, Galos F, Aloi M, De Angelis D, Moretti C, et al. Non-acid gastro-oesophageal reflux in children with suspected pulmonary aspiration. Dig Liver Dis. 2010;42:115-21 pubmed publisher
    ..MII-pH monitoring increases the yield in identifying types and proximal extension of reflux episodes, that discriminate between patients with and without pulmonary aspiration. ..
  44. Lo Scalzo R, Fibiani M, Mennella G, Rotino G, Dal Sasso M, Culici M, et al. Thermal treatment of eggplant (Solanum melongena L.) increases the antioxidant content and the inhibitory effect on human neutrophil burst. J Agric Food Chem. 2010;58:3371-9 pubmed publisher
    ..00 microg/mL. These results showed that the thermal treatment commonly used before consumption can increase the content and biological activity of antioxidant compounds of eggplants...
  45. Rotondo R, Bertolotto M, Barisione G, Astigiano S, Mandruzzato S, Ottonello L, et al. Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation. J Leukoc Biol. 2011;89:721-7 pubmed publisher
    ..These findings suggest that PMNs, recruited at sites of immune complex deposition, induce ARG1-dependent immune suppression through concomitant exocytosis of gelatinase and azurophil granules. ..
  46. Romeo D, Skerlavaj B, Bolognesi M, Gennaro R. Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils. J Biol Chem. 1988;263:9573-5 pubmed
    ..Computer modeling of the dodecapeptide resulted in a conformation in which the chain adopts an antiparallel extended structure forming a gamma turn at residue 7. ..
  47. Carletto A, Bellavite P, Guarini P, Biasi D, Chirumbolo S, Caramaschi P, et al. Changes of fatty acid composition and oxidative metabolism of human neutrophils migrating into an inflammatory exudate. Inflammation. 1996;20:123-37 pubmed
  48. Peduto A, Krauth V, Collarile S, Dehm F, Ambruosi M, Belardo C, et al. Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition. Eur J Med Chem. 2016;108:466-475 pubmed publisher
    ..The reported in vivo analysis, together with the accessible synthetic procedure, stimulate for the generation of further potent antinflammatory benzoindoles-based agents. ..
  49. Bellavite P, Carletto A, Biasi D, Caramaschi P, Poli F, Suttora F, et al. Studies of skin-window exudate human neutrophils: complex patterns of adherence to serum-coated surfaces in dependence on FMLP doses. Inflammation. 1994;18:575-87 pubmed
    ..Therefore, the adherence of SW cells appears to be regulated in a complex fashion, nonlinearly dependent on the chemotactic peptide doses and specifically regulated according to the receptors involved. ..
  50. Cuzzocrea S, Costantino G, Mazzon E, Micali A, De Sarro A, Caputi A. Beneficial effects of melatonin in a rat model of splanchnic artery occlusion and reperfusion. J Pineal Res. 2000;28:52-63 pubmed
  51. Trevisani F, Castelli E, Foschi F, Parazza M, Loggi E, Bertelli M, et al. Impaired tuftsin activity in cirrhosis: relationship with splenic function and clinical outcome. Gut. 2002;50:707-12 pubmed
    ..Such an abnormality appears to be related to impaired splenic function and severity of cirrhosis, and probably favours the occurrence of bacterial infections. ..
  52. Capsoni F, Sarzi Puttini P, Atzeni F, Minonzio F, Bonara P, Doria A, et al. Effect of adalimumab on neutrophil function in patients with rheumatoid arthritis. Arthritis Res Ther. 2005;7:R250-5 pubmed
  53. Decleva E, Menegazzi R, Busetto S, Patriarca P, Dri P. Common methodology is inadequate for studies on the microbicidal activity of neutrophils. J Leukoc Biol. 2006;79:87-94 pubmed
  54. Monaco S, Sparano V, Gioia M, Sbardella D, Di Pierro D, Marini S, et al. Enzymatic processing of collagen IV by MMP-2 (gelatinase A) affects neutrophil migration and it is modulated by extracatalytic domains. Protein Sci. 2006;15:2805-15 pubmed
    ..MMP-2 action negatively affects the neutrophils' migration across type IV coated membranes and this is likely related to the production of lower molecular weight fragments that impair the cellular migration. ..
  55. Maugeri N, Baldini M, Ramirez G, Rovere Querini P, Manfredi A. Platelet-leukocyte deregulated interactions foster sterile inflammation and tissue damage in immune-mediated vessel diseases. Thromb Res. 2012;129:267-73 pubmed publisher
    ..Here we will discuss the implications of these results for the pathogenesis and the clinical features of self-sustaining immune-mediated vessel diseases. ..
  56. Brizzi M, Aronica M, Rosso A, Bagnara G, Yarden Y, Pegoraro L. Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes. J Biol Chem. 1996;271:3562-7 pubmed
    ..These results identify a new signal transduction pathway activated by GM-CSF and provide a mechanism for rapid activation of gene expression in GM-CSF-stimulated PMN. ..
  57. McDonald P, Cassatella M. Activation of transcription factor NF-kappa B by phagocytic stimuli in human neutrophils. FEBS Lett. 1997;412:583-6 pubmed
    ..To our knowledge, this represents the first demonstration that phagocytic stimuli can induce NF-kappa B activation in human neutrophils. ..
  58. Leonardi A, Borghesan F, Faggian D, Depaoli M, Secchi A, Plebani M. Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases. Am J Ophthalmol. 2000;129:151-8 pubmed
    ..Although none of the above markers can be considered specific to a single disease, their measurement may still be useful for the quantification of local cell activation in ocular inflammatory diseases. ..
  59. D Andrea D, Ravera M, Golino P, Rosica A, De Felice M, Ragni M, et al. Induction of tissue factor in the arterial wall during recurrent thrombus formation. Arterioscler Thromb Vasc Biol. 2003;23:1684-9 pubmed
    ..This phenomenon may contribute to sustain intravascular thrombus formation after the initial thrombogenic stimulus. ..
  60. Gresele P, Ribaldi E, Mezzasoma A, Quero E, Stasi M, Prosdocimi M, et al. Cloricromene inhibits leukotriene formation by human polymorphonuclear leucocytes by suppressing arachidonate release from membrane phospholipids. Biochem Pharmacol. 1993;45:123-30 pubmed
  61. Dusi S, Donini M, Rossi F. Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox. Biochem J. 1996;314 ( Pt 2):409-12 pubmed
    ..These findings indicate that, on neutrophil stimulation, p67phox mediates the translocation of p40phox and Rac1 from the cytosol to cell membranes and that Rac2 associates with the membranes independently of p47phox and p67phox. ..
  62. Vimercati L, Santarelli L, Pesola G, Drago I, Lasorsa G, Valentino M, et al. Monocyte-macrophage system and polymorphonuclear leukocytes in workers exposed to low levels of metallic mercury. Sci Total Environ. 2001;270:157-63 pubmed
    ..Therefore, we suggest that impairment of these parameters provide a sensitive indicator of metallic mercury and other chemical contaminants present in the environment. ..
  63. Lecchi C, Ceciliani F, Bernasconi S, Franciosi F, Bronzo V, Sartorelli P. Bovine alpha-1 acid glycoprotein can reduce the chemotaxis of bovine monocytes and modulate CD18 expression. Vet Res. 2008;39:50 pubmed publisher
  64. Marzano A, Menicanti C, Crosti C, Trevisan V. Neutrophilic dermatoses and inflammatory bowel diseases. G Ital Dermatol Venereol. 2013;148:185-96 pubmed
  65. McDonald P, Bald A, Cassatella M. Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils. Blood. 1997;89:3421-33 pubmed
  66. Agostini C, Trentin L, Facco M, Semenzato G. New aspects of hypersensitivity pneumonitis. Curr Opin Pulm Med. 2004;10:378-82 pubmed
    ..It is possible that these data could allow the discovery of therapeutic targets in individuals chronically exposed to HP antigens and evolving towards pulmonary fibrosis. ..
  67. Braga P, Dal Sasso M, Culici M, Bianchi T, Bordoni L, Marabini L. Anti-inflammatory activity of thymol: inhibitory effect on the release of human neutrophil elastase. Pharmacology. 2006;77:130-6 pubmed
    ..These two latter characteristics make thymol a molecule that can have helpful effects in controlling the inflammatory processes present in many infections. ..
  68. Sangaletti S, Tripodo C, Chiodoni C, Guarnotta C, Cappetti B, Casalini P, et al. Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood. 2012;120:3007-18 pubmed publisher
    ..These data provide the first demonstration that NET structures are highly immunogenic such to trigger adaptive immune response relevant for autoimmunity. ..
  69. Ottonello L, Frumento G, Arduino N, Bertolotto M, Dapino P, Mancini M, et al. Differential regulation of spontaneous and immune complex-induced neutrophil apoptosis by proinflammatory cytokines. Role of oxidants, Bax and caspase-3. J Leukoc Biol. 2002;72:125-32 pubmed
    ..The results also unveil the existence of an oxidant-independent, Bax- and caspase-3-dependent, intracellular pathway regulating neutrophil apoptosis. ..
  70. Montecucco F, Bianchi G, Bertolotto M, Viviani G, Dallegri F, Ottonello L. Insulin primes human neutrophils for CCL3-induced migration: crucial role for JNK 1/2. Ann N Y Acad Sci. 2006;1090:399-407 pubmed
    ..Finally, biochemical analysis herein carried out raises the hypothesis of JNK 1/2 as an attractive therapeutic target. ..
  71. Maugeri N, Rovere Querini P, Slavich M, Coppi G, Doni A, Bottazzi B, et al. Early and transient release of leukocyte pentraxin 3 during acute myocardial infarction. J Immunol. 2011;187:970-9 pubmed publisher
    ..PTX3 binds to activated circulating platelets and dampens their proinflammatory and prothrombotic action, thus possibly contributing to its cardioprotective effects. ..
  72. Thorén F, Riise R, Ousbäck J, Della Chiesa M, Alsterholm M, Marcenaro E, et al. Human NK Cells induce neutrophil apoptosis via an NKp46- and Fas-dependent mechanism. J Immunol. 2012;188:1668-74 pubmed publisher
    ..Our findings provide evidence that NK cells may accelerate neutrophil apoptosis, and that this interaction may be involved in the resolution of acute inflammation. ..
  73. Jaillon S, Moalli F, Ragnarsdottir B, Bonavita E, Puthia M, Riva F, et al. The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection. Immunity. 2014;40:621-32 pubmed publisher
    ..These results suggest that PTX3 is an essential component of innate resistance against UTIs. Thus, the cellular and humoral arms of innate immunity exert complementary functions in mediating resistance against UTIs. ..
  74. Mocali A, Paoletti F. Transketolase from human leukocytes. Isolation, properties and induction of polyclonal antibodies. Eur J Biochem. 1989;180:213-9 pubmed
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