Genomes and Genes
Experts and Doctors on neuropeptides in United States
Locale: United States
Publications232 found, 100 shown here
- Al Anzi B, Armand E, Nagamei P, Olszewski M, Sapin V, Waters C, et al. The leucokinin pathway and its neurons regulate meal size in Drosophila. Curr Biol. 2010;20:969-78 pubmed publisher..Our results suggest that the roles of the tachykinin system in regulating food intake might be evolutionarily conserved between insects and vertebrates. ..
- Schmeichel B, Berridge C. Wake-promoting actions of noradrenergic ?1 - and ?-receptors within the lateral hypothalamic area. Eur J Neurosci. 2013;37:891-900 pubmed publisher..Collectively, these observations indicate that noradrenergic ?1 -receptors within the LHA promote arousal via actions that are independent of HCRT neuronal activation. ..
- Zigmond R, Sun Y. Regulation of neuropeptide expression in sympathetic neurons. Paracrine and retrograde influences. Ann N Y Acad Sci. 1997;814:181-97 pubmed..Expression of substance P after axotomy occurs primarily, if not entirely, because of the effects of LIF, with the removal of NGF playing no obvious role in the regulation of this peptide. ..
- Wilson L, Wayman C, Jackson V. Neuropeptide modulation of a lumbar spinal reflex: potential implications for female sexual function. J Sex Med. 2009;6:947-957 pubmed publisher..Melanocortins, oxytocin, CRF, and DAMGO have the ability to modulate orgasm whereas oxytocin, CRF and DAMGO can increase pain threshold. Oxytocin and CRF may dampen touch sensation. ..
- Pasumarthi R, Fadel J. Stimulation of lateral hypothalamic glutamate and acetylcholine efflux by nicotine: implications for mechanisms of nicotine-induced activation of orexin neurons. J Neurochem. 2010;113:1023-35 pubmed publisher..Changes in cholinergic or glutamatergic transmission in this region with chronic nicotine may contribute to long-term alterations in functions mediated by LH/PFA neurons, including feeding and arousal. ..
- Delgado M, Ganea D. Inhibition of endotoxin-induced macrophage chemokine production by vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide in vitro and in vivo. J Immunol. 2001;167:966-75 pubmed..These findings support the proposed role of VIP and PACAP as key endogenous anti-inflammatory agents and describe a novel mechanism, i.e., the inhibition of the production of macrophage-derived chemokines. ..
- Park Y, Kim Y, Adams M. Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc Natl Acad Sci U S A. 2002;99:11423-8 pubmed..These findings support a theory of coevolution for NMU and Drosophila PRXa peptides and their respective receptors. ..
- Frederick Duus D, Guyton M, Fadel J. Food-elicited increases in cortical acetylcholine release require orexin transmission. Neuroscience. 2007;149:499-507 pubmed
- Zhan S, Zhao H, J White A, Minami M, Pignataro G, Yang T, et al. Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains. J Cereb Blood Flow Metab. 2009;29:698-706 pubmed publisher..We conclude that brain ischemia attenuates PC2 and PC2-mediated neuropeptide processing. This attenuation may play a role in the pathology of ischemic brain injury. ..
- ..Recent evidence suggests that activity EE has an important role in dictating lifespan and thus places emphasis on future research to uncover the underlying biological mechanisms. The study of EE continues to unlock clues to aging. ..
- Wu D, Haruta A, Wei Q. GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion. J Biol Chem. 2010;285:28643-50 pubmed publisher..Thus, our results suggest that GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion...
- Manohar S, Paolone N, Bleichfeld M, Hayes S, Salvi R, Baizer J. Expression of doublecortin, a neuronal migration protein, in unipolar brush cells of the vestibulocerebellum and dorsal cochlear nucleus of the adult rat. Neuroscience. 2012;202:169-83 pubmed publisher..Another possibility is that UBCs maintain DCX expression even after migration and maturation, reflecting a role of DCX in adult neuronal plasticity in addition to a developmental role in migration. ..
- Schmerberg C, Li L. Mass spectrometric detection of neuropeptides using affinity-enhanced microdialysis with antibody-coated magnetic nanoparticles. Anal Chem. 2013;85:915-22 pubmed publisher..The levels of NPs detected were also sufficient for reliable quantitation with the MS system in use, permitting quantitative analysis of the concentration changes for 7 identified NPs on a 30 min time course during feeding. ..
- Mena J, Selleck R, Baldo B. Mu-opioid stimulation in rat prefrontal cortex engages hypothalamic orexin/hypocretin-containing neurons, and reveals dissociable roles of nucleus accumbens and hypothalamus in cortically driven feeding. J Neurosci. 2013;33:18540-52 pubmed publisher..g., binge eating and opiate or alcohol abuse, disorders in which ?ORs and aberrant cortical activation have been implicated. ..
- Dyer C, Touchette K, Carroll J, Allee G, Matteri R. Cloning of porcine prepro-orexin cDNA and effects of an intramuscular injection of synthetic porcine orexin-B on feed intake in young pigs. Domest Anim Endocrinol. 1999;16:145-8 pubmed..05). The ability to stimulate appetite during critical periods of early growth, particularly following weaning, could result in significant improvements in swine-production efficiency. ..
- Patel S, Campbell D, Strauss H. Elucidating KChIP effects on Kv4.3 inactivation and recovery kinetics with a minimal KChIP2 isoform. J Physiol. 2002;545:5-11 pubmed..KChIP2d is a valuable tool for elucidating structural domains of KChIPs involved in Kv4 channel regulation...
- Raymond C, Castle J, Garrett Engele P, Armour C, Kan Z, Tsinoremas N, et al. Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia. J Biol Chem. 2004;279:46234-41 pubmed..Consistent down-regulation of all transcripts was observed, as well as significant changes in the splicing patterns of SCN8A and SCN9A. ..
- Hassanain H, Irshaid F, Wisel S, Sheridan J, Michler R, Goldschmidt Clermont P. Smooth muscle cell expression of a constitutive active form of human Rac 1 accelerates cutaneous wound repair. Surgery. 2005;137:92-101 pubmed..The current studies suggest that Rac 1 activation accelerates the wound healing process and is associated with more efficient angiogenesis at the wound site. ..
- Ye H, Greer T, Li L. Probing neuropeptide signaling at the organ and cellular domains via imaging mass spectrometry. J Proteomics. 2012;75:5014-5026 pubmed publisher..Future perspectives in this field are also provided, concluding that neuropeptide IMS would greatly facilitate studies of neuronal network and biomarker discovery. ..
- Davis R, Shrimpton A, Holohan P, Bradshaw C, Feiglin D, Collins G, et al. Familial dementia caused by polymerization of mutant neuroserpin. Nature. 1999;401:376-9 pubmed..Our findings provide a molecular mechanism for a familial dementia and imply that inhibitors of protein polymerization may be effective therapies for this disorder and perhaps for other more common neurodegenerative diseases. ..
- Gonzalez Nicolini V, McGinty J. NK-1 receptor blockade decreases amphetamine-induced behavior and neuropeptide mRNA expression in the striatum. Brain Res. 2002;931:41-9 pubmed..These data indicate that striatal NK-1 receptors modulate amphetamine-induced behavior and mRNA expression of neuropeptides in the rat striatum. ..
- Wong D, Anderson L, Tai T. Cholinergic and peptidergic regulation of phenylethanolamine N-methyltransferase gene expression. Ann N Y Acad Sci. 2002;971:19-26 pubmed..However, the magnitude of stimulation and antagonist blockade with H-89 or the polypeptide inhibitor PKI suggests that the extent of activation is much less than that with PACAP. ..
- Kim Y, Spalovsk Valachov I, Cho K, Zitnanova I, Park Y, Adams M, et al. Corazonin receptor signaling in ecdysis initiation. Proc Natl Acad Sci U S A. 2004;101:6704-9 pubmed publisher..These findings support the role of corazonin signaling in initiation of the ecdysis behavioral sequence. We propose a model for peptide-mediated interactions between Inka cells and the CNS underlying this process in insect development...
- Rook J, Hasan W, McCarson K. Morphine-induced early delays in wound closure: involvement of sensory neuropeptides and modification of neurokinin receptor expression. Biochem Pharmacol. 2009;77:1747-55 pubmed publisher..These data provide evidence indicating a potentially detrimental effect of topical morphine application on the dynamic wound healing process. ..
- Lynch K, Ramsey M, Cummings M. The mate choice brain: comparing gene profiles between female choice and male coercive poeciliids. Genes Brain Behav. 2012;11:222-9 pubmed publisher..Both gene expression and female behavioral responses to males exhibit opposing patterns between these species, suggesting that this genetic pathway may potentially act as a substrate for the evolution of mate preference behavior. ..
- Chen F, Zheng H, Hill K, Sha S. Traumatic noise activates Rho-family GTPases through transient cellular energy depletion. J Neurosci. 2012;32:12421-30 pubmed publisher..The sum of the results suggests that traumatic noise induces transient cellular ATP depletion and activates Rho GTPase pathways, leading to death of outer hair cells in the cochlea. ..
- Hatton G. Astroglial modulation of neurotransmitter/peptide release from the neurohypophysis: present status. J Chem Neuroanat. 1999;16:203-21 pubmed..Release of these peptides by the glia or their functional roles in the system have not yet been demonstrated. ..
- Barker Carlson K, Lawrence D, Schwartz B. Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro. J Biol Chem. 2002;277:46852-7 pubmed
- Vanmali B, Romanova E, Messner M, Singh M, Maruniak J, Sweedler J, et al. Endogenous neurotrophic factors enhance neurite growth by bag cell neurons of Aplysia. J Neurobiol. 2003;56:78-93 pubmed..Collagen-like peptides and other factors produced by sheath and arterial cells likely influence neurite growth in the Aplysia CNS during development, learning and memory, and regeneration after injury. ..
- Hauser K, Aldrich J, Anderson K, Bakalkin G, Christie M, Hall E, et al. Pathobiology of dynorphins in trauma and disease. Front Biosci. 2005;10:216-35 pubmed..Evidence outlined in this review suggests that a variety of CNS pathologies alter dynorphin biogenesis. Such alterations are likely maladaptive and contribute to secondary injury and the pathogenesis of disease. ..
- Hallene K, Oby E, Lee B, Santaguida S, Bassanini S, Cipolla M, et al. Prenatal exposure to thalidomide, altered vasculogenesis, and CNS malformations. Neuroscience. 2006;142:267-83 pubmed..Altering this process leads to failure of normal cerebrovascular development and may have a profound implication for CNS maturation. ..
- Huh J, Foe I, Muro I, Chen C, Seol J, Yoo S, et al. The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis i. J Biol Chem. 2007;282:2056-68 pubmed..Therefore, diap2 may identify a point of convergence between apoptosis and immune signaling pathways. ..
- Mair R, Hembrook J. Memory enhancement with event-related stimulation of the rostral intralaminar thalamic nuclei. J Neurosci. 2008;28:14293-300 pubmed publisher..They also provide evidence that treatments stimulating rostral ILn activity may be an effective means to enhance working memory and related cognitive processes and thus to treat disorders that affect these functions. ..
- Nishi R, Stubbusch J, Hulce J, Hruska M, Pappas A, Bravo M, et al. The cortistatin gene PSS2 rather than the somatostatin gene PSS1 is strongly expressed in developing avian autonomic neurons. J Comp Neurol. 2010;518:839-50 pubmed publisher..The identification of PSS2 as the predominantly expressed somatostatin gene family member in avian autonomic neurons provides a molecular basis for further functional and pharmacological studies. ..
- Stanley E, Fadel J. Aging-related alterations in orexin/hypocretin modulation of septo-hippocampal amino acid neurotransmission. Neuroscience. 2011;195:70-9 pubmed publisher..Alterations in orexin regulation of septo-hippocampal activity may contribute to age-related dysfunctions in arousal, learning, and memory. ..
- Lin E. Neuropeptides as therapeutic targets in anxiety disorders. Curr Pharm Des. 2012;18:5709-27 pubmed..Human studies indicating a role for these neuropeptides in anxiety disorders will also be discussed. ..
- O Connell L, Hofmann H. Evolution of a vertebrate social decision-making network. Science. 2012;336:1154-7 pubmed publisher..Our analysis suggests that the diversity of social behavior in vertebrates can be explained, in part, by variations on a theme of conserved neural and gene expression networks. ..
- Stallings Mann M, Waldmann J, Zhang Y, Miller E, Gauthier M, Visscher D, et al. Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Sci Transl Med. 2012;4:142ra95 pubmed publisher..Rac1b is expressed abundantly in stages 1 and 2 of human lung adenocarcinomas and, hence, is an attractive molecular target for the development of new therapies that prevent progression to later-stage lung cancers. ..
- Mahler S, Smith R, Moorman D, Sartor G, Aston Jones G. Multiple roles for orexin/hypocretin in addiction. Prog Brain Res. 2012;198:79-121 pubmed publisher..Finally, we attempt to contextualize the role of orexins in reward by discussing ways in which these peptides, expressed in only a few thousand neurons in the brain, can have such wide-ranging effects on behavior. ..
- Larsen N, Womack J, Kirkpatrick B. Seven genes from human chromosome 18 map to chromosome 24 in the bovine. Cytogenet Cell Genet. 1996;73:184-6 pubmed..These STSs were used for synteny mapping, and all seven genes were syntenic with markers of bovine chromosome (BTA) 24. The concordance with BTA 24 was at least 96.5% for all genes. ..
- Su D, Ellis S, Napier A, Lee K, Manley N. Hoxa3 and pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis. Dev Biol. 2001;236:316-29 pubmed..Our results suggest that a Hoxa3-Pax1 genetic pathway is required for both epithelial cell growth and differentiation throughout thymus and parathyroid organogenesis. ..
- Tzaferis J, McGinty J. Kappa opioid receptor stimulation decreases amphetamine-induced behavior and neuropeptide mRNA expression in the striatum. Brain Res Mol Brain Res. 2001;93:27-35 pubmed..16 mg/kg. These data suggest that stimulation of kappa receptors decreases acute amphetamine-induced behavior and mRNA expression of neuropeptides in the rat striatum. ..
- Teal P, Nachman R. A brominated-fluorene insect neuropeptide analog exhibits pyrokinin/PBAN-specific toxicity for adult females of the tobacco budworm moth. Peptides. 2002;23:801-6 pubmed
- Bhattacharya A, Lakhman S, Singh S. Modulation of L-type calcium channels in Drosophila via a pituitary adenylyl cyclase-activating polypeptide (PACAP)-mediated pathway. J Biol Chem. 2004;279:37291-7 pubmed..The data also provide support for functional homology between human PACAP-38 and the amn gene product in Drosophila. ..
- Cone R. Anatomy and regulation of the central melanocortin system. Nat Neurosci. 2005;8:571-8 pubmed
- Means J, Muro I, Clem R. Lack of involvement of mitochondrial factors in caspase activation in a Drosophila cell-free system. Cell Death Differ. 2006;13:1222-34 pubmed..The Hid peptide also induced apoptosis when introduced into S2 cells. These results suggest that caspase activation in Drosophila is regulated solely by cytoplasmic factors and does not involve any mitochondrial factors. ..
- Grady S, Nishino S, Czeisler C, Hepner D, Scammell T. Diurnal variation in CSF orexin-A in healthy male subjects. Sleep. 2006;29:295-7 pubmed..Orexin-A levels vary moderately between subjects, but are quite consistent within the same subject. Thus, for the diagnostic evaluation of narcolepsy, the time of CSF collection should have little impact. ..
- Glavas M, Grayson B, Allen S, Copp D, Smith M, Cowley M, et al. Characterization of brainstem peptide YY (PYY) neurons. J Comp Neurol. 2008;506:194-210 pubmed..Collectively, the projection pattern and association with orexigenic neuropeptides suggest that brainstem PYY neurons may play a role in energy homeostasis through a coordinated effect on visceral, motor, and sympathetic output targets. ..
- Ghosh A, Walls K, Klocke B, Toms R, Strasser A, Roth K. The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis. J Neuropathol Exp Neurol. 2009;68:747-56 pubmed publisher..Collectively, these studies indicate a p53-independent, Bax- and Puma-dependent mechanism of neuronal apoptosis and identify Puma as a possible molecular target for inhibiting the effects of intrauterine ethanol exposure in humans. ..
- Szabo F, Snyder N, Usdin T, Hoffman G. A direct neuronal connection between the subparafascicular and ventrolateral arcuate nuclei in non-lactating female rats. Could this pathway play a role in the suckling-induced prolactin release?. Endocrine. 2010;37:62-70 pubmed publisher..The presented findings suggest that the ascending fibers from the subparafascicular parvocellular nucleus might be in the pathway involved in the suckling-induced prolactin release. ..
- Gunapala K, Gallardo C, Hsu C, Steele A. Single gene deletions of orexin, leptin, neuropeptide Y, and ghrelin do not appreciably alter food anticipatory activity in mice. PLoS ONE. 2011;6:e18377 pubmed publisher..Collectively, these results suggest that the individual hormones and neuropepetides tested do not regulate FAA by acting individually but this does not rule out the possibility of their concerted action in mediating FAA. ..
- Blanco Centurion C, Liu M, Konadhode R, Pelluru D, Shiromani P. Effects of orexin gene transfer in the dorsolateral pons in orexin knockout mice. Sleep. 2013;36:31-40 pubmed publisher..In contrast, GFP gene transfer worsened narcoleptic symptoms compared to the no-rAAV orexin KO group. Orexin gene transfer into the dorsolateral pontine neurons can control cataplexy attacks and modestly improve wake maintenance. ..
- Latchney S, Hein A, O Banion M, Dicicco Bloom E, Opanashuk L. Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory. J Neurochem. 2013;125:430-45 pubmed publisher..Moreover, TCDD exposure should be considered as an environmental risk factor that disrupts adult neurogenesis and potentially related memory processes. ..
- Seabold G, Burette A, Lim I, Weinberg R, Hell J. Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102. J Biol Chem. 2003;278:15040-8 pubmed
- Dong X, Mo Z, Bokoch G, Guo C, Li Z, Wu D. P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol. 2005;15:1874-9 pubmed..Furthermore, P-Rex1 deficiency caused a chemotactic defect that is primarily attributed to a reduction in the migration rate rather than directionality. ..
- Black J. Narcolepsy: a review of evidence for autoimmune diathesis. Int Rev Psychiatry. 2005;17:461-9 pubmed..Future research must focus on elucidation of immune markers and early ameliorative treatments for narcolepsy. ..
- Cao C, Liu Y, Lehmann M. Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. J Cell Biol. 2007;176:843-52 pubmed..More generally, they suggest that cell identity factors like Fkh play a pivotal role in the normal control of developmental cell death. ..
- Fu Q, Tang L, Marder E, Li L. Mass spectrometric characterization and physiological actions of VPNDWAHFRGSWamide, a novel B type allatostatin in the crab, Cancer borealis. J Neurochem. 2007;101:1099-107 pubmed..Surprisingly, despite marked amino-acid sequence dissimilarity between the novel CbAST-B1 and the A type allatostatin family of peptides (AST-A), the physiological effects of CbAST-B1 are similar to those of AST-A. ..
- Cape S, Rehm K, Ma M, Marder E, Li L. Mass spectral comparison of the neuropeptide complement of the stomatogastric ganglion and brain in the adult and embryonic lobster, Homarus americanus. J Neurochem. 2008;105:690-702 pubmed..Collectively, this study expands our current knowledge of the H. americanus neuropeptidome and highlights some intriguing expression differences that occur during development. ..
- Bae H, Zmijewski J, Deshane J, Tadie J, Chaplin D, Takashima S, et al. AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils. FASEB J. 2011;25:4358-68 pubmed publisher..control (P<0.05). These results demonstrate a novel function for AMPK in enhancing the phagocytic activity of neutrophils and macrophages. ..
- Proskocil B, Sekhon H, Jia Y, Savchenko V, Blakely R, Lindstrom J, et al. Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology. 2004;145:2498-506 pubmed publisher..This pathway may also explain some of the effects of nicotine on fetal development and also provides additional mechanisms by which smoking affects lung cancer growth and development...
- Li Q, Liston P, Schokman N, Ho J, Moyer R. Amsacta moorei Entomopoxvirus inhibitor of apoptosis suppresses cell death by binding Grim and Hid. J Virol. 2005;79:3684-91 pubmed..Both Grim and Hid were demonstrated to interact with AMV-IAP in vivo, and Grim- or Hid-induced cell death was suppressed when AMV-IAP was coexpressed...
- Barkus R, Klyachko O, Horiuchi D, Dickson B, Saxton W. Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides. Mol Biol Cell. 2008;19:274-83 pubmed..This suggests that Unc-104, a member of an anterograde kinesin subfamily, contributes to an organelle-specific dynein-driven retrograde transport mechanism. ..
- Dube M, Kalra S, Kalra P. Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res. 1999;842:473-7 pubmed..These findings demonstrate that orexin A receptive sites for stimulation of food intake exist primarily in a narrow band of neural tissue within the hypothalamus that is known to be involved in control of energy homeostasis. ..
- McGinty J. Co-localization of GABA with other neuroactive substances in the basal ganglia. Prog Brain Res. 2007;160:273-84 pubmed..The net result of their actions is a homeostatic response that regulates striatal output and balances dopamine and glutamate receptor stimulation. ..
- Vittoz N, Schmeichel B, Berridge C. Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons. Eur J Neurosci. 2008;28:1629-40 pubmed publisher..Moreover, these and other observations suggest that the dysregulation of HCRT-DA interactions could contribute to cognitive/affective dysfunction associated with a variety of behavioral disorders. ..
- Ring R, Alder J, Fennell M, Kouranova E, Black I, Thakker Varia S. Transcriptional profiling of brain-derived-neurotrophic factor-induced neuronal plasticity: a novel role for nociceptin in hippocampal neurite outgrowth. J Neurobiol. 2006;66:361-77 pubmed..These results reveal a novel role for nociceptin and suggest that these neuropeptide systems may contribute to the regulation of neuronal function by BDNF. ..
- Sherwood T, Askwith C. Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a. J Biol Chem. 2008;283:1818-30 pubmed..Furthermore, our finding that endogenous peptides shift steady-state desensitization suggests that RF-amides could impact the role of ASIC1a in both pain and neuronal damage following stroke and ischemia. ..
- Kintos N, Nusbaum M, Nadim F. A modeling comparison of projection neuron- and neuromodulator-elicited oscillations in a central pattern generating network. J Comput Neurosci. 2008;24:374-97 pubmed..Our results illustrate how the actions of bath-applied neuromodulators can mimic those of descending projection neurons through mathematically similar but physiologically distinct mechanisms. ..
- Loftis J, Wilhelm C, Vandenbark A, Huckans M. Partial MHC/neuroantigen peptide constructs: a potential neuroimmune-based treatment for methamphetamine addiction. PLoS ONE. 2013;8:e56306 pubmed publisher..Collectively, these initial results indicate that neuroimmune targeted therapies, and specifically RTL551, may have potential as treatments for methamphetamine-induced neuropsychiatric impairments...
- Bucelli R, Gonsiorek E, Kim W, Bruun D, Rabin R, Higgins D, et al. Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons. J Pharmacol Exp Ther. 2008;324:1172-80 pubmed
- Suckow S, Caudle R. NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity. Mol Pain. 2009;5:54 pubmed publisher..Therefore, these data suggest that CANs contribute to visceral hypersensitivity during inflammation. ..
- Nocjar C, Zhang J, Feng P, Panksepp J. The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus. Neuroscience. 2012;218:138-53 pubmed publisher..These findings suggest that orexin and dynorphin function may be imbalanced between the hypothalamus and mesocortical dopaminergic brain regions in depression. ..
- Cason A, Aston Jones G. Role of orexin/hypocretin in conditioned sucrose-seeking in rats. Psychopharmacology (Berl). 2013;226:155-65 pubmed publisher..These findings lead us to conclude that conditioned activation of Orx neurons increases motivation for food reward during food restriction. ..
- Wang S, Hawkins C, Yoo S, Muller H, Hay B. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell. 1999;98:453-63 pubmed
- Scalettar B, Rosa P, Taverna E, Francolini M, Tsuboi T, Terakawa S, et al. Neuronal calcium sensor-1 binds to regulated secretory organelles and functions in basal and stimulated exocytosis in PC12 cells. J Cell Sci. 2002;115:2399-412 pubmed..These results also reveal interesting similarities and differences between transport organelles in differentiated neuroendocrine cells and neurons. ..
- Wismer Fries A, Ziegler T, Kurian J, Jacoris S, Pollak S. Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior. Proc Natl Acad Sci U S A. 2005;102:17237-40 pubmed..The present findings are consistent with the view that there is a critical role for early experience in the development of the brain systems underlying basic aspects of human social behavior. ..
- Davis K, Banerjee S, Friggeri A, Bell C, Abraham E, Zerfaoui M. Poly(ADP-ribosyl)ation of high mobility group box 1 (HMGB1) protein enhances inhibition of efferocytosis. Mol Med. 2012;18:359-69 pubmed publisher..The present results, showing that PARylation of HMGB1 enhances its ability to inhibit efferocytosis, provide a novel mechanism by which PARP-1 may promote inflammation. ..
- Bruijnzeel A. Tobacco addiction and the dysregulation of brain stress systems. Neurosci Biobehav Rev. 2012;36:1418-41 pubmed publisher..Drugs that decrease the activity of brain stress systems may diminish nicotine withdrawal and improve smoking cessation rates. ..
- Petraglia A, Marky A, Walker C, Thiyagarajan M, Zlokovic B. Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery. 2010;66:165-71; discussion 171-2 pubmed publisher..The present findings suggest that APC therapy may hold a significant therapeutic potential for TBI. ..
- DeKeyser S, Kutz Naber K, Schmidt J, Barrett Wilt G, Li L. Imaging mass spectrometry of neuropeptides in decapod crustacean neuronal tissues. J Proteome Res. 2007;6:1782-91 pubmed..Collectively, this organ-level IMS study elucidates the spatial relationships between multiple neuropeptide isoforms of the same family as well as the relative distributions of neuropeptide families. ..