Experts and Doctors on neuropeptides in Japan

Summary

Locale: Japan
Topic: neuropeptides

Top Publications

  1. Kikuchi K, Arawaka S, Koyama S, Kimura H, Ren C, Wada M, et al. An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. Biochem Biophys Res Commun. 2003;308:646-54 pubmed
    ..Our results suggest that sequestration of the N-terminal fragment of proSAAS in intracellular PBs may cause a functional disturbance of neurons in Pick's disease. ..
  2. Kiso T, Watabiki T, Tsukamoto M, Okabe M, Kagami M, Nishimura K, et al. Pharmacological characterization and gene expression profiling of an L5/L6 spinal nerve ligation model for neuropathic pain in mice. Neuroscience. 2008;153:492-500 pubmed publisher
    ..The pattern changes in gene expression also resembled those reported in rats. This model will therefore be useful for investigation of the effects of novel antinociceptive compounds and the mechanisms of neuropathic pain. ..
  3. Hayashi M, Itoh M, Araki S, Kumada S, Tanuma N, Kohji T, et al. Immunohistochemical analysis of brainstem lesions in infantile spasms. Neuropathology. 2000;20:297-303 pubmed
    ..It is intriguing that some of the changes seemed to be interrelated with the neurophysiological abnormalities being reported in IS patients. ..
  4. Usuki S, Kotani E. Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on progestin biosynthesis in cultured luteal cells from rat ovary. Gynecol Endocrinol. 2001;15:184-91 pubmed
    ..PACAP-38 also suppressed increases in LH receptor content in cultured luteal cells. These results suggest that PACAP regulates the effects of LH on luteal cell function and that PACAP might be closely linked to reproduction...
  5. Ito E, Okada R, Sakamoto Y, Otshuka E, Mita K, Okuta A, et al. Insulin and memory in Lymnaea. Acta Biol Hung. 2012;63 Suppl 2:194-201 pubmed publisher
  6. Saito Y, Tsujino N, Hasegawa E, Akashi K, Abe M, Mieda M, et al. GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons. Front Neural Circuits. 2013;7:192 pubmed publisher
    ..Optogenetic stimulation of these fibers resulted in rapid inhibition of orexin neurons. These observations suggest direct connectivity between POA GABAergic neurons and orexin neurons. ..
  7. Saito Y, Maruyama K, Saido T, Kawashima S. N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin. Biochem Biophys Res Commun. 1995;217:539-45 pubmed
    ..These findings suggest that the N23K protein functions not only as a neuropeptide precursor but also as an important component in neuronal differentiation. ..
  8. Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, Muraki Y, et al. Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron. 2005;46:297-308 pubmed
    ..These neuroanatomical findings provide important insights into the neural pathways that regulate sleep/wakefulness states. ..
  9. Mitake S, Ojika K, Katada E, Otsuka Y, Matsukawa N, Fujimori O. Accumulation of hippocampal cholinergic neurostimulating peptide (HCNP)-related components in Hirano bodies. Neuropathol Appl Neurobiol. 1995;21:35-40 pubmed

More Information

Publications119 found, 100 shown here

  1. Niidome T, Taniuchi N, Akaike A, Kihara T, Sugimoto H. Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice. Neuroreport. 2008;19:1361-4 pubmed publisher
    ..These results suggest that neurogenesis, probably reflecting the survival of neural progenitor cells, differs between the subgranular zone and the subventricular zone. ..
  2. Sasaki Y, Hayashi K, Shirao T, Ishikawa R, Kohama K. Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones. J Neurochem. 1996;66:980-8 pubmed
    ..Our results suggest that fascin might play an important role in the organization of actin in filopodia and that this organization might be regulated by drebrin. ..
  3. Asazuma H, Nagata S, Katayama H, Ohira T, Nagasawa H. Characterization of a molt-inhibiting hormone (MIH) receptor in the Y-organ of the kuruma prawn, Marsupenaeus japonicus. Ann N Y Acad Sci. 2005;1040:215-8 pubmed
    ..76 x 10(-10) M and B(max) = 5.51 x 10(-12) M). Chemical cross-linking between [(125)I]rMIH and the membrane fraction of the Y-organ revealed that the MIH receptor protein has a molecular size of approximately 70 kDa. ..
  4. Mieda M, Sakurai T. Overview of orexin/hypocretin system. Prog Brain Res. 2012;198:5-14 pubmed publisher
    ..Here, we briefly summarize the progress of orexin/hypocretin studies and future perspectives. ..
  5. Konishi Y, Ohkawa N, Makino Y, Ohkubo H, Kageyama R, Furuichi T, et al. Transcriptional regulation of mouse type 1 inositol 1,4,5-trisphosphate receptor gene by NeuroD-related factor. J Neurochem. 1999;72:1717-24 pubmed
    ..From these results, we suggest that NDRF is involved in the tissue-specific regulation of IP3R1 gene expression in the CNS. ..
  6. Endo H, Nagasawa H, Watanabe T. Isolation of a cDNA encoding a CHH-family peptide from the silkworm Bombyx mori. Insect Biochem Mol Biol. 2000;30:355-61 pubmed
    ..BmCHHL expression was detected in five or six cells (per hemisphere) in the frontal area of the brain in day 4 fifth instar larvae. ..
  7. Yamamoto Y, Ootsuka T, Atoji Y, Suzuki Y. Tyrosine hydroxylase- and neuropeptides-immunoreactive nerves in canine trachea. Am J Vet Res. 2000;61:1380-3 pubmed
    ..Complex innervation, including catecholamine- and neuropeptide-containing nerves, which may be related to regulation of muscle contraction and glandular secretion, are found in canine tracheas. ..
  8. Isobe K, Tatsuno I, Yashiro T, Nanmoku T, Takekoshi K, Kawakami Y, et al. Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis. Regul Pept. 2003;110:213-7 pubmed
    ..0342) levels in 16 intra-adrenal pheochromocytomas. Our findings support a possible role for PACAP in the regulation of expression of genes encoding catecholamine-synthesizing enzymes in intra-adrenal pheochromocytomas. ..
  9. Naritsuka H, Sakai K, Hashikawa T, Mori K, Yamaguchi M. Perisomatic-targeting granule cells in the mouse olfactory bulb. J Comp Neurol. 2009;515:409-26 pubmed publisher
    ..These findings indicate the morphological differentiation of GCs into dendritic-targeting and perisomatic-targeting subsets, and suggest the functional differentiation of the GC subsets in the processing of odor information in the OB. ..
  10. Kanbayashi T, Shimohata T, Nakashima I, Yaguchi H, Yabe I, Nishizawa M, et al. Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implications. Arch Neurol. 2009;66:1563-6 pubmed publisher
    ..To characterize factors that contribute to symptomatic narcolepsy and excessive daytime sleepiness in neuromyelitis optica and multiple sclerosis...
  11. Ito N, Hori A, Yabe T, Nagai T, Oikawa T, Yamada H, et al. Involvement of neuropeptide Y signaling in the antidepressant-like effect and hippocampal cell proliferation induced by kososan, a Kampo medicine, in the stress-induced depression-like model mice. Biol Pharm Bull. 2012;35:1775-83 pubmed
  12. Mizumoto A, Fujimura M, Ohtawa M, Ueki S, Hayashi N, Itoh Z, et al. Pituitary adenylate cyclase activating polypeptide stimulates gallbladder motility in conscious dogs. Regul Pept. 1992;42:39-50 pubmed
    ..It was concluded that PACAP27 and PACAP38 stimulate gallbladder motility in conscious dogs through a preganglionic cholinergic mechanism. ..
  13. Shimomura Y, Harada M, Goto M, Sugo T, Matsumoto Y, Abe M, et al. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J Biol Chem. 2002;277:35826-32 pubmed
    ..These findings indicate that neuropeptide W is the endogenous ligand for both GPR7 and GPR8 and acts as a mediator of the central control of feeding and the neuroendocrine system. ..
  14. Kondo S, Yamamoto N, Murakami T, Okumura M, Mayeda A, Imaizumi K. Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. Genes Cells. 2004;9:121-30 pubmed
    ..SRp30c also enhanced the splicing of tau exon 10. These results suggest that mutations in tau exon 10 that are linked to FTDP-17 affect the ESE activities by altering the binding of some SR proteins to its pre-mRNA. ..
  15. Ohno K, Hondo M, Sakurai T. Cholinergic regulation of orexin/hypocretin neurons through M(3) muscarinic receptor in mice. J Pharmacol Sci. 2008;106:485-91 pubmed
    ..These results indicate that CCh activates 20% of orexin neurons through the M(3) muscarinic receptor and subsequent activation of nonselective cation channels. ..
  16. Murata M, Kosaka R, Kurihara K, Yamashita S, Tachibana H. Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression. Biosci Biotechnol Biochem. 2016;80:1636-40 pubmed publisher
    ..Microarray analysis showed that delphinidin suppresses the upregulation of oxidative stress-related gene expression, including the expression of Cbl-b. Thus, delphinidin may prevent unloading-mediated muscle atrophy. ..
  17. Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, et al. Identification and characterization of a novel human cortistatin-like peptide. Biochem Biophys Res Commun. 1997;232:157-63 pubmed
    ..These results indicate that a bioactive peptide encoded by the cDNA is a human counterpart corresponding to rat CST. ..
  18. Yoshida I, Tsuzuki S, Abdel Salam S, Ino M, Korayem A, Sakurai S, et al. Bombyxin F1 gene: structure and expression of a new bombyxin family gene that forms a pair with bombyxin B10 gene. Zoolog Sci. 1997;14:615-22 pubmed
    ..Genomic Southern hybridization indicated that the Bombyx haploid genome contains a single copy of the family-F bombyxin gene. ..
  19. Fukumoto E, Sakai H, Fukumoto S, Yagi T, Takagi O, Kato Y. Cadherin-related neuronal receptors in incisor development. J Dent Res. 2003;82:17-22 pubmed
    ..These results suggest that CNR1 and CNR5 may play an important role in enamel and dentin formation, probably through cell-cell and/or cell-matrix interactions. ..
  20. Katsukura Y, Ando H, David C, Grimmelikhuijzen C, Sugiyama T. Control of planula migration by LWamide and RFamide neuropeptides in Hydractinia echinata. J Exp Biol. 2004;207:1803-10 pubmed
    ..Since sensory neurons containing LWamides and RFamides are present in planula larvae, it appears likely that planula migration is regulated by the release of endogenous neuropeptides in response to environmental cues. ..
  21. Kanamori Y, Hayakawa Y, Matsumoto H, Yasukochi Y, Shimura S, Nakahara Y, et al. A eukaryotic (insect) tricistronic mRNA encodes three proteins selected by context-dependent scanning. J Biol Chem. 2010;285:36933-44 pubmed publisher
    ..Thus, eukaryotes have a cellular tricistronic mRNA that encodes three functionally related proteins as in an operon...
  22. Kimura C, Ohkubo S, Ogi K, Hosoya M, Itoh Y, Onda H, et al. A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. Biochem Biophys Res Commun. 1990;166:81-9 pubmed
    ..Cloning of PACAP38 cDNAs confirms the expression of the corresponding mRNAs and the presence of this neuropeptide in ovine hypothalamus and also in human testis. ..
  23. Kitamura A, Nagasawa H, Kataoka H, Inoue T, Matsumoto S, Ando T, et al. Amino acid sequence of pheromone-biosynthesis-activating neuropeptide (PBAN) of the silkworm, Bombyx mori. Biochem Biophys Res Commun. 1989;163:520-6 pubmed
    ..Examination of PBAN activity of synthetic analogues indicated that the carboxyl-terminal portion of PBAN-I was important for biological activity. ..
  24. Yada T, Sakurada M, Nakata M, Ihida K, Yaekura K, Shioda S, et al. Current status of PACAP as a regulator of insulin secretion in pancreatic islets. Ann N Y Acad Sci. 1996;805:329-40; discussion 341-2 pubmed
    ..Finally, we hypothesize that PACAP is a pancreatic peptide of both neural and islet origin and functions as an intrinsic potentiator of glucose-induced insulin secretion in pancreatic islets (FIG 6). ..
  25. Ikemoto T, Park M. Chicken RFamide-related peptide (GnIH) and two distinct receptor subtypes: identification, molecular characterization, and evolutionary considerations. J Reprod Dev. 2005;51:359-77 pubmed
    ..It was also suggested that functional differences, especially between avian and mammalian RFRPs, are substantially due to divergences in the structures and expression sites of their receptors...
  26. Tsujino N, Yamanaka A, Ichiki K, Muraki Y, Kilduff T, Yagami K, et al. Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor. J Neurosci. 2005;25:7459-69 pubmed
    ..The evidence presented here expands our understanding of the regulation of orexin neurons and the physiological role of CCK in the CNS. ..
  27. Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, et al. PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. PLoS ONE. 2011;6:e18324 pubmed publisher
    ..These results suggested that PDK1 and Foxo1 signaling pathways play important roles in the control of energy homeostasis through AGRP-independent mechanisms. ..
  28. Ojika K, Kojima S, Ueki Y, Fukushima N, Hayashi K, Yamamoto M. Purification and structural analysis of hippocampal cholinergic neurostimulating peptide. Brain Res. 1992;572:164-71 pubmed
    ..These observations suggested that HCNP was present in the hippocampal extract and was involved in development of specific cholinergic neuron in central nervous system. ..
  29. Kato M, Kanai M, Soma O, Takusa Y, Kimura T, Numakura C, et al. Mutation of the doublecortin gene in male patients with double cortex syndrome: somatic mosaicism detected by hair root analysis. Ann Neurol. 2001;50:547-51 pubmed
    ..We conclude that somatic mosaic mutations in the doublecortin gene in male patients can cause subcortical band heterotopia, and that molecular analysis using hair roots is a useful method for detecting somatic mosaicism. ..
  30. Ukena K, Koda A, Yamamoto K, Kobayashi T, Iwakoshi Ukena E, Minakata H, et al. Novel neuropeptides related to frog growth hormone-releasing peptide: isolation, sequence, and functional analysis. Endocrinology. 2003;144:3879-84 pubmed
    ..In contrast, fGRP-RPs did not have any appreciable effect on the release of gonadotropins. Thus, fGRP-RP-2 may act as a novel hypothalamic factor on the frog pituitary to stimulate the release of GH and PRL. ..
  31. Takano K, Kitao Y, Inagi R, Momoi T, Matsuyama T, Miyata T, et al. A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies). Biochem Biophys Res Commun. 2006;346:1040-7 pubmed
    ..Tg meg rats provide a novel model of FENIB, where accumulation of serpins in the ER induces selective dysfunction/loss of specific neuronal populations. ..
  32. Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, et al. Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. PLoS ONE. 2013;8:e62391 pubmed publisher
    ..These observations suggest the importance of neurotensin in maintaining activity of orexin neurons. The evidence presented here expands our understanding of the regulatory mechanism of orexin neurons. ..
  33. Osugi T, Son Y, Ubuka T, Satake H, Tsutsui K. RFamide peptides in agnathans and basal chordates. Gen Comp Endocrinol. 2016;227:94-100 pubmed publisher
  34. Hinuma S, Shintani Y, Fukusumi S, Iijima N, Matsumoto Y, Hosoya M, et al. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol. 2000;2:703-8 pubmed
    ..Our results indicate that a variety of RFamide-related peptides may exist and function in mammals. ..
  35. Yamanaka A, Muraki Y, Tsujino N, Goto K, Sakurai T. Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem Biophys Res Commun. 2003;303:120-9 pubmed
    ..Our data suggest that orexin neurons have reciprocal neural circuitries between these nuclei for either a positive or negative feedback loop and orchestrate the activity of these neurons to regulate the vigilance states. ..
  36. Miyamoto Y, Chen L, Sato M, Sokabe M, Nabeshima T, Pawson T, et al. Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor. J Neurosci. 2005;25:1826-35 pubmed
  37. Imamura K, Shirao T, Mori K, Obata K. Changes of drebrin expression in the visual cortex of the cat during development. Neurosci Res. 1992;13:33-41 pubmed
  38. Matsuoka K, Taoka M, Satozawa N, Nakayama H, Ichimura T, Takahashi N, et al. A nuclear factor containing the leucine-rich repeats expressed in murine cerebellar neurons. Proc Natl Acad Sci U S A. 1994;91:9670-4 pubmed
    ..The structural characteristics, localization, and the stage- and cell type-specific expression suggest a potential role of LANP in a signal transduction pathway that directs differentiation of cerebellar neurons. ..
  39. Imaizumi K, Tsuda M, Imai Y, Wanaka A, Takagi T, Tohyama M. Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death. J Biol Chem. 1997;272:18842-8 pubmed
    ..Overexpression of the full-length DP5 in cultured sympathetic neurons was in itself sufficient to induce apoptosis. These results suggest that DP5 plays a role in programmed neuronal death. ..
  40. Ubuka T, Ukena K, Sharp P, Bentley G, Tsutsui K. Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail. Endocrinology. 2006;147:1187-94 pubmed
    ..To our knowledge, GnIH is the first identified hypothalamic neuropeptide inhibiting reproductive function in any vertebrate class. ..
  41. Asai H, Hirano M, Furiya Y, Udaka F, Morikawa M, Kanbayashi T, et al. Cerebrospinal fluid-orexin levels and sleep attacks in four patients with Parkinson's disease. Clin Neurol Neurosurg. 2009;111:341-4 pubmed publisher
    ..Despite the small number of patients studied, our results suggest that orexin transmission is most likely involved in SAs in PD and that abrogation of D3 receptor stimulation may increase orexin and thereby inhibit SAs. ..
  42. Hua Y, Tanaka Y, Nakamura K, Sakakibara M, Nagata S, Kataoka H. Identification of a prothoracicostatic peptide in the larval brain of the silkworm, Bombyx mori. J Biol Chem. 1999;274:31169-73 pubmed
    ..This peptide inhibited PTTH-stimulated ecdysteroidogenesis in the PG at both the spinning and feeding stages, which indicates that Bom-PTSP interferes with PTTH-stimulated ecdysteroidogenesis. ..
  43. Hara J, Beuckmann C, Nambu T, Willie J, Chemelli R, Sinton C, et al. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron. 2001;30:345-54 pubmed
    ..Orexin/ataxin-3 mice provide a valuable model for studying the pathophysiology and treatment of narcolepsy. ..
  44. Kanbayashi T, Inoue Y, Chiba S, Aizawa R, Saito Y, Tsukamoto H, et al. CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia. J Sleep Res. 2002;11:91-3 pubmed
    ..Low CSF hypocretin-1 is therefore very specific for HLA DR2 positive narcolepsy-cataplexy, and the deficiency is likely to be established at the early stage of the disease...
  45. Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, et al. Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. J Biol Chem. 2002;277:34010-6 pubmed
    ..We believe this is the first report on a neuropeptide modified with bromine and have hence named it neuropeptide B. In in vitro assays, bromination did not influence the binding of neuropeptide B to the receptor...
  46. Yasuda A, Yasuda Kamatani Y, Nozaki M, Nakajima T. Identification of GYRKPPFNGSIFamide (crustacean-SIFamide) in the crayfish Procambarus clarkii by topological mass spectrometry analysis. Gen Comp Endocrinol. 2004;135:391-400 pubmed
    ..These results suggested that the neuropeptide family might be widely distributed in arthropods and plays a significant role in the nervous system. ..
  47. Niimi M. Centrally administered neuropeptide S activates orexin-containing neurons in the hypothalamus and stimulates feeding in rats. Endocrine. 2006;30:75-9 pubmed
    ..These results suggest that arousal and feeding induced by NPS in the central nervous system may be related to the activation of orexin-expressing neurons. ..
  48. Matsuki T, Sakurai T. Orexins and orexin receptors: from molecules to integrative physiology. Results Probl Cell Differ. 2008;46:27-55 pubmed publisher
    ..In this chapter, we discuss the current understanding of the physiological roles of orexins in regulation of arousal, sleep/wake states, energy homeostasis, and reward systems. ..
  49. Kawano T, Kataoka H, Nagasawa H, Isogai A, Suzuki A. cDNA cloning and sequence determination of the pheromone biosynthesis activating neuropeptide of the silkworm, Bombyx mori. Biochem Biophys Res Commun. 1992;189:221-6 pubmed
    ..Thus, the PBAN gene products construct a family of structurally related peptides and have various biological functions. ..
  50. Kataoka H, Nagasawa H, Isogai A, Ishizaki H, Suzuki A. Prothoracicotropic hormone of the silkworm, Bombyx mori: amino acid sequence and dimeric structure. Agric Biol Chem. 1991;55:73-86 pubmed
    ..Bombyx PTTH is expected to contain a carbohydrate chain bound to an asparagine at position 41, deduced from the cDNA sequence...
  51. Hosoya M, Kimura C, Ogi K, Ohkubo S, Miyamoto Y, Kugoh H, et al. Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. Biochim Biophys Acta. 1992;1129:199-206 pubmed
    ..Furthermore, we determined the locus of the gene to be 18p11 by the chromosomal in situ hybridization technique. ..
  52. Higashijima S, Shishido E, Matsuzaki M, Saigo K. eagle, a member of the steroid receptor gene superfamily, is expressed in a subset of neuroblasts and regulates the fate of their putative progeny in the Drosophila CNS. Development. 1996;122:527-36 pubmed
  53. Itoh H, Tomita M, Uchino H, Kobayashi T, Kataoka H, Sekiya R, et al. cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis. Biochem J. 1996;318 ( Pt 3):939-44 pubmed
  54. Kuwahara H, Araki N, Makino K, Masuko N, Honda S, Kaibuchi K, et al. A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor. J Biol Chem. 1999;274:32204-14 pubmed
    ..These findings suggest that alternative splicing of nedasin may play a role in the formation and/or structural change in synapses during neuronal development by modifying clustering of neurotransmitter receptors at the synaptic sites. ..
  55. Ueda H, Baba T, Kashiwagi K, Iijima H, Ohno S. Dystrobrevin localization in photoreceptor axon terminals and at blood-ocular barrier sites. Invest Ophthalmol Vis Sci. 2000;41:3908-14 pubmed
    ..In addition, dystrobrevin is localized at the blood-ocular barrier sites in extraocular tissue. These data suggest that dystrobrevin plays an important role in visual function. ..
  56. Takahashi T, Kobayakawa Y, Muneoka Y, Fujisawa Y, Mohri S, Hatta M, et al. Identification of a new member of the GLWamide peptide family: physiological activity and cellular localization in cnidarian polyps. Comp Biochem Physiol B Biochem Mol Biol. 2003;135:309-24 pubmed
    ..fuscoviridis. In each case, nerve cells were specifically labeled. These results suggest that the GLWamides are ubiquitous among cnidarians and are involved in regulating the excitability of specific muscles. ..
  57. Onoue S, Hanato J, Yamada S. Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. FEBS J. 2008;275:5542-51 pubmed publisher
    ..The data obtained suggest the anti-apoptotic role of PACAP in streptozotocin-treated RIN-m5F cells through the regulation of pro-apoptotic and pro-survival factors. ..
  58. Tsujino N, Sakurai T. Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol Rev. 2009;61:162-76 pubmed publisher
    ..Therefore, this system may be a potentially important therapeutic target for treatment of sleep disorder, obesity, emotional stress, and addiction. ..
  59. Mieda M, Hasegawa E, Kisanuki Y, Sinton C, Yanagisawa M, Sakurai T. Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J Neurosci. 2011;31:6518-26 pubmed publisher
    ..Thus, each orexin receptor subtype plays differential roles in gating NREM and REM sleep through distinct neuronal pathways. ..
  60. Hata T, Chen J, Ebihara K, Date Y, Ishida Y, Nakahara D. Intra-ventral tegmental area or intracerebroventricular orexin-A increases the intra-cranial self-stimulation threshold via activation of the corticotropin-releasing factor system in rats. Eur J Neurosci. 2011;34:816-26 pubmed publisher
  61. Namba T, Kibe Y, Funahashi Y, Nakamuta S, Takano T, Ueno T, et al. Pioneering axons regulate neuronal polarization in the developing cerebral cortex. Neuron. 2014;81:814-29 pubmed publisher
    ..These results show that the TAG-1-mediated cell-to-cell interaction between the unpolarized multipolar cells and the pioneering axons regulates the polarization of multipolar cells partly through Lyn kinase and Rac1. ..
  62. Kitamura A, Nagasawa H, Kataoka H, Ando T, Suzuki A. Amino acid sequence of pheromone biosynthesis activating neuropeptide-II (PBAN-II) of the silkmoth, Bombyx mori. Agric Biol Chem. 1990;54:2495-7 pubmed
  63. Sawada M, Ogata M, Fujino Y, Hamaoka T. cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells. Biochem Biophys Res Commun. 1994;203:479-84 pubmed
    ..In thymocytes subpopulations, PTP36 was preferentially expressed in double positive stage cells. The change of PTP36 expression level along with T cell maturation suggests its involvement in the regulation of T cell development. ..
  64. Kondo H, Ino M, Suzuki A, Ishizaki H, Iwami M. Multiple gene copies for bombyxin, an insulin-related peptide of the silkmoth Bombyx mori: structural signs for gene rearrangement and duplication responsible for generation of multiple molecular forms of bombyxin. J Mol Biol. 1996;259:926-37 pubmed publisher
    ..Duplications may have served to multiply the bombyxin gene triplets. These genomic rearrangements are thought to have led to the generation of multiple bombyxin gene copies and their diversity in structure and genomic organization...
  65. Ojika K, Ueki Y, Mitake S, Tsugu Y, Otsuka Y, Katada E. Demonstration of the biological activity of peptide fragments related to human and rat hippocampal cholinergic neurostimulating peptide (HCNP). Neurosci Lett. 1996;215:127-30 pubmed
    ..Tetrapeptides and hexapeptides whose C-terminus is this common sequence enhanced acetylcholine production, indicating that the minimum consensus sequence for HCNP activity is X-Gly-Pro-Leu. ..
  66. Birenheide R, Tamori M, Motokawa T, Ohtani M, Iwakoshi E, Muneoka Y, et al. Peptides controlling stifness of connective tissue in sea cucumbers. Biol Bull. 1998;194:253-9 pubmed
    ..The results suggest that the peptides are neuropeptides and are part of a sophisticated system of neurotransmitters and neuromodulators that controls the connective tissue stiffness of sea cucumber dermis...
  67. Wu C, Asakawa S, Shimizu N, Kawasaki S, Yasukochi Y. Construction and characterization of bacterial artificial chromosome libraries from the silkworm, Bombyx mori. Mol Gen Genet. 1999;261:698-706 pubmed
    ..These results show that it is possible to construct contigs and analyze chromosome organization using these libraries. ..
  68. Tateishi K, Misumi Y, Ikehara Y, Miyasaka K, Funakoshi A. Molecular cloning and expression of rat antisecretory factor and its intracellular localization. Biochem Cell Biol. 1999;77:223-8 pubmed
    ..These findings suggest that the protein proposed to be AF may be a cytoplasmic protein, it exists in the intestine rather than being transported from the pituitary gland, and it may function in intestinal cells. ..
  69. Furukawa Y, Nakamaru K, Wakayama H, Fujisawa Y, Minakata H, Ohta S, et al. The enterins: a novel family of neuropeptides isolated from the enteric nervous system and CNS of Aplysia. J Neurosci. 2001;21:8247-61 pubmed
    ..Furthermore, because enterins are present throughout the nervous system, they may also play a regulatory role in nonfeeding behaviors of Aplysia...
  70. Ohkubo T, Tsukada A, Shamoto K. cDNA cloning of chicken orexin receptor and tissue distribution: sexually dimorphic expression in chicken gonads. J Mol Endocrinol. 2003;31:499-508 pubmed
    ..In addition, orexin may have specific role(s) in the regulation of gonadal function in which sex-dependent mechanisms could be involved. ..
  71. Fujita T, Ikuta J, Hamada J, Okajima T, Tatematsu K, Tanizawa K, et al. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Biochem Biophys Res Commun. 2004;313:738-44 pubmed
    ..These results suggest that FEZ2 plays an important role in the morphological changes of various cells by associating with PKCzeta in a tissue-non-specific manner. ..
  72. Fukusumi S, Fujii R, Hinuma S. Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP. Peptides. 2006;27:1073-86 pubmed
    ..We review here the strategies employed for the identification of these peptides and examine their characteristics, tissue distribution, receptors and functions. ..
  73. Sakurai T. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci. 2007;8:171-81 pubmed
    ..The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis. ..
  74. Toshinai K, Yamaguchi H, Kageyama H, Matsuo T, Koshinaka K, Sasaki K, et al. Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus. Am J Physiol Endocrinol Metab. 2010;299:E394-401 pubmed publisher
    ..Thus, VGF serves as a precursor of multiple bioactive peptides exerting a diverse set of neuroendocrine functions. ..
  75. Nakazawa C, Shikata K, Uesugi M, Katayama H, Aoshima K, Tahara K, et al. Prediction of relaxin-3-induced downstream pathway resulting in anxiolytic-like behaviors in rats based on a microarray and peptidome analysis. J Recept Signal Transduct Res. 2013;33:224-33 pubmed publisher
    ..These results suggest that RLX3 acts as an anxiolytic peptide and that the downstream pathways mediated by its receptors may be potential candidates for the treatment of anxieties in the future. ..
  76. Kida T, Omori K, Hori M, Ozaki H, Murata T. Stimulation of G protein-coupled bile acid receptor enhances vascular endothelial barrier function via activation of protein kinase A and Rac1. J Pharmacol Exp Ther. 2014;348:125-30 pubmed publisher
    ..These results indicate that stimulation of GPBAR enhances endothelial barrier function by cAMP/PKA/Rac1-dependent cytoskeletal rearrangement. ..
  77. Kojima N, Yasuda H, Hanamura K, Ishizuka Y, Sekino Y, Shirao T. Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice. Neuroscience. 2016;324:218-26 pubmed publisher
  78. Okazaki K, Kimura C, Kosaka T, Watanabe T, Ohkubo S, Ogi K, et al. Expression of human pituitary adenylate cyclase activating polypeptide (PACAP) cDNA in CHO cells and characterization of the products. FEBS Lett. 1992;298:49-56 pubmed
    ..The ir-PACAPs were confirmed to ahve biological activities such as induction of cAMP and neurite outgrowth in rat pheochromocytoma PC12h cells. ..
  79. Ogi K, Kimura C, Onda H, Arimura A, Fujino M. Molecular cloning and characterization of cDNA for the precursor of rat pituitary adenylate cyclase activating polypeptide (PACAP). Biochem Biophys Res Commun. 1990;173:1271-9 pubmed
    ..Northern blot analysis of rat brain RNA revealed an approximately 3.0 kb transcript for the PACAP precursor in rat brain. ..
  80. Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S. Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron. 1993;11:333-42 pubmed
    ..In situ hybridization revealed a high level of expression of PACAP receptor mRNA in the hippocampal dentate gyrus, olfactory bulb, and cerebellar cortex. ..
  81. Toyooka K, Iritani S, Makifuchi T, Shirakawa O, Kitamura N, Maeda K, et al. Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia. J Neurochem. 2002;83:797-806 pubmed
    ..In addition, neuroleptic treatment failed to mimic the SAP97 change. These findings suggest that a phenotypic loss of SAP97 is associated with the postsynaptic impairment in prefrontal excitatory circuits of schizophrenic patients. ..
  82. Zhang S, Mizutani A, Hisatsune C, Higo T, Bannai H, Nakayama T, et al. Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells. J Biol Chem. 2003;278:4048-56 pubmed
    ..1N blocks the localization of co-expressed IP(3)R1 at the basolateral membrane domain. These data indicate that 4.1N is required for IP(3)R1 translocation to the basolateral membrane domain in polarized MDCK cells. ..
  83. Usuki S, Kotani E. Tokishakuyakusan directly attenuates PACAP's luteolytic action on luteal function in the rat ovary. Am J Chin Med. 2002;30:521-31 pubmed
    ..The data further suggest that TS tends to attenuate PACAP's inhibition of LH-stimulated progesterone production, suggesting a luteotrophic effect within the corpus luteum. ..
  84. Mochizuki R, Dateki M, Yanai K, Ishizuka Y, Amizuka N, Kawashima H, et al. Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality. Biochem Biophys Res Commun. 2003;310:1219-26 pubmed
    ..5 and 6.5 dpc. This result indicates that neurochondrin/norbin gene function is essential for the early embryogenesis. ..
  85. Tancharoen S, Sarker K, Imamura T, Biswas K, Matsushita K, Tatsuyama S, et al. Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling. J Immunol. 2005;174:5796-804 pubmed
    ..This new RgpB activity suggests a possible link between periodontitis and pulp inflammation, which may be modulated by neuropeptides released in the lesion. ..
  86. Fukuda A, Hikita A, Wakeyama H, Akiyama T, Oda H, Nakamura K, et al. Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1. J Bone Miner Res. 2005;20:2245-53 pubmed
    ..Rac1 also plays a significant role in the bone resorptive activity of cells, probably by regulating the motility of osteoclasts. ..
  87. Matsumoto S, Yamazaki C, Masumoto K, Nagano M, Naito M, Soga T, et al. Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Proc Natl Acad Sci U S A. 2006;103:4140-5 pubmed
    ..Our current findings demonstrated that physiological activation of PKR2 is essential for normal development of the OB and sexual maturation...
  88. Sakamoto T, Oda A, Yamamoto K, Kaneko M, Kikuyama S, Nishikawa A, et al. Molecular cloning and functional characterization of a prolactin-releasing peptide homolog from Xenopus laevis. Peptides. 2006;27:3347-51 pubmed
    ..PrRP mRNA levels in the developing Xenopus brain peak in early prometamorphosis, different from prolactin levels. PrRP may not be a major prolactin-releasing factor (PRF), at least in adult frogs, as in mammals. ..
  89. Ohno K, Sakurai T. Orexin neuronal circuitry: role in the regulation of sleep and wakefulness. Front Neuroendocrinol. 2008;29:70-87 pubmed
    ..This review discusses the mechanism by which orexins maintain sleep/wakefulness states, and how this mechanism relates to other systems that regulate emotion, reward, and energy homeostasis. ..
  90. Toriyama M, Mizuno N, Fukami T, Iguchi T, Toriyama M, Tago K, et al. Phosphorylation of doublecortin by protein kinase A orchestrates microtubule and actin dynamics to promote neuronal progenitor cell migration. J Biol Chem. 2012;287:12691-702 pubmed publisher
    ..Our data reveal a dual reciprocal role for DCX phosphorylation in the regulation of microtubule and actin dynamics that is indispensable for proper brain lamination. ..
  91. Takenaka N, Izawa R, Wu J, Kitagawa K, Nihata Y, Hosooka T, et al. A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle. FEBS J. 2014;281:1493-504 pubmed publisher
    ..Taken together, these results strongly suggest a novel regulatory link between Akt2 and Rac1 in insulin-dependent signal transduction leading to glucose uptake in skeletal muscle. ..
  92. Maeda T, Yuzawa S, Suzuki A, Baba Y, Nishimura Y, Kato Y. RhoA mediates the expression of acidic extracellular pH-induced matrix metalloproteinase-9 mRNA through phospholipase D1 in mouse metastatic B16-BL6 melanoma cells. Int J Oncol. 2016;48:1251-7 pubmed publisher
    ..In contrast, PLD2 inhibition or knockout had no effect on MMP-9 expression. These findings suggested that RhoA-PLD1 signaling is involved in acidic pHe induction of MMP-9. ..